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Atsuko Ikenouchi,1,2 Yusuke Konno,1,3 Yoshihisa Fujino,3 Naoto Adachi,4 Yukihisa Kubota,4 Takaharu Azekawa,4 Hitoshi Ueda,4 Koji Edagawa,4 Eiichi Katsumoto,4 Eiichiro Goto,4 Seiji Hongo,4 Masaki Kato,5,6 Takashi Tsuboi,5,7 Norio Yasui-Furukori,5,8 Atsuo Nakagawa,5,9 Toshiaki Kikuchi,5,9 Koichiro Watanabe,5,7 Reiji Yoshimura1,5 1Department of Psychiatry, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan; 2Medical Center for Dementia, Hospital of the University of Occupational and Environmental Health, Japan, Kitakyushu, Japan; 3Department of Environmental Epidemiology, Institute of Ecological Sciences, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan; 4The Japanese Association of Neuro-Psychiatric Clinics, Tokyo, Japan; 5The Japanese Society of Clinical Neuropsychopharmacology, Tokyo, Japan; 6Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan; 7Department of Neuropsychiatry, Kyorin University, Tokyo, Japan; 8Department of Psychiatry, Dokkyo Medical University, Tochigi, Japan; 9Department of Neuropsychiatry, Keio University, Tokyo, JapanCorrespondence: Atsuko Ikenouchi, Department of Psychiatry, University of Occupational and Environmental Health, Japan, 1-1 Iseigaoka, Yahatanishiku, Kitakyushu, 807-8555, Japan, Tel +81-93-691-7253, Fax +81-93-692-4894, Email atsuko-i@med.uoeh-u.ac.jpPurpose: To clarify the relationship between the length of unstable periods and employment status of patients with bipolar disorder.Patients and Methods: Medical records of outpatients with bipolar disorder who visited 176 member clinics of the Japanese Association of Neuro-Psychiatric Clinics were investigated during September–October 2016, and details of their medical care and employment were surveyed using a questionnaire. The odds ratios (ORs) of length of unstable period and unemployment were analyzed with a logistic regression model.Results: The study included 816 patients, of whom 707 were employed full

Burn time errors caused by various start-up transient effects have a significant influence on the regression modelling of hybrid rockets. Their influence is especially pronounced in the simulation model of the Cascaded Multi Impinging Jet (CAMUI) hybrid rocket engine. This paper analyses these transient burn time errors and their effect on the regression simulations for short burn time engines. To address these errors, the equivalent burn time is introduced and is defined as the time the engine would burn if it were burning at its steady-state level throughout the burn time to achieve the measured total impulse. The accuracy of the regression simulation with and without the use of equivalent burn time is then finally compared. Equivalent burn time is shown to address the burn time issue successfully for port regression and, therefore, also for other types of cylindrical port hybrid rocket engines. For the CAMUI-specific impinging jet fore-end and back-end surfaces, though, the results are inconclusive.

Burn time errors caused by various start-up transient effects have a significant influence on the regression modelling of hybrid rockets. Their influence is especially pronounced in the simulation model of the Cascaded Multi Impinging Jet (CAMUI) hybrid rocket engine. This paper analyses these transient burn time errors and their effect on the regression simulations for short burn time engines. To address these errors, the equivalent burn time is introduced and is defined as the time the engine would burn if it were burning at its steady-state level throughout the burn time to achieve the measured total impulse. The accuracy of the regression simulation with and without the use of equivalent burn time is then finally compared. Equivalent burn time is shown to address the burn time issue successfully for port regression and, therefore, also for other types of cylindrical port hybrid rocket engines. For the CAMUI-specific impinging jet fore-end and back-end surfaces, though, the results are inconclusive.

Yusuke Konno,1,2 Yoshihisa Fujino,2 Atsuko Ikenouchi,1,3 Naoto Adachi,4 Yukihisa Kubota,4 Takaharu Azekawa,4 Hitoshi Ueda,4 Koji Edagawa,4 Eiichi Katsumoto,4 Eiichiro Goto,4 Seiji Hongo,4 Masaki Kato,5,6 Takashi Tsuboi,5,7 Norio Yasui-Furukori,5,8 Atsuo Nakagawa,5,9 Toshiaki Kikuchi,5,9 Koichiro Watanabe,5,7 Reiji Yoshimura1,5 1Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan; 2Department of Environmental Epidemiology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan; 3Medical Center for Dementia, University Hospital of Occupational and Environmental Health, Kitakyushu, Japan; 4The Japanese Association of Neuro-Psychiatric Clinics, Tokyo, Japan; 5The Japanese Society of Clinical Neuropsychopharmacology, Tokyo, Japan; 6Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan; 7Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan; 8Department of Psychiatry, Dokkyo Medical University, Tochigi, Japan; 9Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, JapanCorrespondence: Yusuke KonnoDepartment of Psychiatry, University of Occupational and Environmental Health, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu, 807-8555, JapanTel +81-93-691-7401Fax +81-93-692-4894Email yu-konno@med.uoeh-u.ac.jpObjective: The objective of this study was to clarify the relationship between mood episode and employment in patients with bipolar disorder to help improve their employment status.Methods: All medical records of patients with bipolar disorder who visited 176 member clinics of the Japanese Association of Neuro-Psychiatric Clinics in September–October 2016 were investigated in September–October 2017. Details of the medical care received were investigated using a survey sheet, which included employment status. Odds ratios of mood episodes for employment status were analyzed using a logistic regression model.

In this study, we propose a new method to design a smooth implicit control Lyapunov function and a smooth control law for a multi-integrator system with an input constraint. The proposed controller is almost linear near the origin, and it tends to a homogeneous controller of the previous implicit Lyapunov function methods as the state goes to infinity. The proposed method can be used for the backstepping method with a restricted virtual input, which is a nonlinear function of the state, and the desired virtual input is designed as a bounded function. Furthermore, we apply our method to the control of a magnetic levitation system, and a simulation result presents the advantage of the proposed method. (C) 2020 The Authors. Published by Elsevier B.V.

In this study, we propose a new method to design a smooth implicit control Lyapunov function and a smooth control law for a multi-integrator system with an input constraint. The proposed controller is almost linear near the origin, and it tends to a homogeneous controller of the previous implicit Lyapunov function methods as the state goes to infinity. The proposed method can be used for the backstepping method with a restricted virtual input, which is a nonlinear function of the state, and the desired virtual input is designed as a bounded function. Furthermore, we apply our method to the control of a magnetic levitation system, and a simulation result presents the advantage of the proposed method. (C) 2020 The Authors. Published by Elsevier B.V.

In this study, we propose a new method to design a smooth implicit control Lyapunov function and a smooth control law for a multi-integrator system with an input constraint. The proposed controller is almost linear near the origin, and it tends to a homogeneous controller of the previous implicit Lyapunov function methods as the state goes to infinity. The proposed method can be used for the backstepping method with a restricted virtual input, which is a nonlinear function of the state, and the desired virtual input is designed as a bounded function. Furthermore, we apply our method to the control of a magnetic levitation system, and a simulation result presents the advantage of the proposed method. (C) 2020 The Authors. Published by Elsevier B.V.

A recently developed reconstruction technique is used to investigate graphite nozzle erosion in two scales of hybrid rocket motors, 30-N-thrust class and 2000-N-thrust class, using oxygen as the oxidizer and high-density polyethylene as the fuel. Thermocouple measurements taken from within the nozzles are used to estimate nozzle throat wall temperature. Forty-four static firing tests were conducted under varying experimental conditions to confirm the validity of the reconstruction technique results, to investigate the conditions at the onset of erosion, and to formulate an empirical predictive model of nozzle erosion rate. Results show that a single formula that treats the combustion gas as a single oxidizing agent for which heterogenous rate constants are functions of equivalence ratio can satisfactorily replicate the erosion rate of graphite by a combustion gas containing multiple oxidizing species. Furthermore, the chemical-kinetic-limited conditions of the onset of nozzle erosion are specified by a novel empirical correlation, which shows that erosion begins at lower temperature and pressure in oxidizer-rich combustion gas than in fuel-rich combustion gas.

A recently developed reconstruction technique is used to investigate graphite nozzle erosion in two scales of hybrid rocket motors, 30-N-thrust class and 2000-N-thrust class, using oxygen as the oxidizer and high-density polyethylene as the fuel. Thermocouple measurements taken from within the nozzles are used to estimate nozzle throat wall temperature. Forty-four static firing tests were conducted under varying experimental conditions to confirm the validity of the reconstruction technique results, to investigate the conditions at the onset of erosion, and to formulate an empirical predictive model of nozzle erosion rate. Results show that a single formula that treats the combustion gas as a single oxidizing agent for which heterogenous rate constants are functions of equivalence ratio can satisfactorily replicate the erosion rate of graphite by a combustion gas containing multiple oxidizing species. Furthermore, the chemical-kinetic-limited conditions of the onset of nozzle erosion are specified by a novel empirical correlation, which shows that erosion begins at lower temperature and pressure in oxidizer-rich combustion gas than in fuel-rich combustion gas.

In this study, we propose a new method to design a smooth implicit control Lyapunov function and a smooth control law for a multi-integrator system with an input constraint. The proposed controller is almost linear near the origin, and it tends to a homogeneous controller of the previous implicit Lyapunov function methods as the state goes to infinity. The proposed method can be used for the backstepping method with a restricted virtual input, which is a nonlinear function of the state, and the desired virtual input is designed as a bounded function. Furthermore, we apply our method to the control of a magnetic levitation system, and a simulation result presents the advantage of the proposed method. (C) 2020 The Authors. Published by Elsevier B.V.

Takashi Tsuboi,1,2 Takefumi Suzuki,2,3 Takaharu Azekawa,4 Naoto Adachi,4 Hitoshi Ueda,4 Kouji Edagawa,4 Eiichi Katsumoto,4 Yukihisa Kubota,4 Eiichiro Goto,4 Seiji Hongo,4 Yoichiro Watanabe,4 Masaki Kato,2,5 Norio Yasui-Furukori,2,6 Reiji Yoshimura,2,7 Atsuo Nakagawa,2,8 Toshiaki Kikuchi,2,8 Koichiro Watanabe1,2 1Department of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan; 2The Japanese Society of Clinical Neuropsychopharmacology, Tokyo, Japan; 3Department of Neuropsychiatry, University of Yamanashi Faculty of Medicine, Yamanashi, Japan; 4The Japanese Association of Neuro-Psychiatric Clinics, Tokyo, Japan; 5Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan; 6Department of Psychiatry, Dokkyo Medical University, Tochigi, Japan; 7Department of Psychiatry, University of Occupational and Environmental Health, Fukuoka, Japan; 8Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, JapanCorrespondence: Takashi TsuboiDepartment of Neuropsychiatry, Kyorin University School of Medicine, 6-20-2, Shinkawa, Mitaka-Shi, Tokyo 181-8611, JapanTel +81 422 47 5511Fax +81 422 45 4697Email takashi.tsuboi.0821@gmail.comPurpose: The aim of this study was to identify factors associated with non-remission in bipolar disorder.Patients and Methods: The multicenter treatment survey for bipolar disorder in psychiatric outpatient clinics (MUSUBI) study used a questionnaire administered at 176 clinics throughout Japan from September to October 2016. Clinic psychiatrists performed a retrospective medical record survey of consecutive cases with bipolar disorder. Patients were considered to be in remission if they met all of the following criteria: they were not in a mixed state, their manic or depressive symptoms were either borderline or nonexistent (corresponding to 2 or 1 points on the Clinical Global Impressions Scale, Bipolar Version), and their psychiatrists clinically considered them to be in remission. Enrolled patients were clas