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1. Stump Appendicitis: A Complication of Post Appendectomy

Author: Maawa Merza Juma, Tahera Ahmed Fateel, Rahul Sam Mathew, Soumya Sunil Nair, Ali Merza Juma, Haider, Ali, Zainab Khalil Mohamed Al-Saati, Maawa Merza Juma, Tahera Ahmed Fateel, Rahul Sam Mathew, Soumya Sunil Nair, Ali Merza Juma, Haider, Ali, and Zainab Khalil Mohamed Al-Saati
Abstract: Stump appendicitis is a rare but serious complication that can occur after an appendectomy, characterized by inflammation and infection of the remaining portion of the appendix (1). Patients typically present with symptoms similar to those of appendicitis, such as abdominal pain, fever, and nausea. However, the diagnosis can be challenging because the patient has previously undergone an appendectomy, potentially leading to delays in treatment and increased risk of complications (1). In this case, a 38-year-old male, who had a smooth recovery following a laparoscopic appendectomy 15 years prior presented to the emergency department with worsening abdominal pain. Despite his initial postoperative recovery, he developed stump appendicitis, as confirmed by a CT scan. The condition was managed with antibiotics and a percutaneous drain, leading to significant improvement. He is now scheduled for a completed appendectomy to remove the remaining appendix stump. This case highlights the critical importance of including stump appendicitis in the differential diagnosis for patients with a history of appendectomy who present with acute abdominal pain. Timely diagnosis and intervention are essential to prevent complications and ensure appropriate management.
Published: 2024

2. The Brescia Internationally Validated European Guidelines on Minimally Invasive Pancreatic Surgery (EGUMIPS)

Author: Abu Hilal, Mohammad, Van Ramshorst, Tess M.E., Boggi, Ugo, Dokmak, Safi, Edwin, Bjørn, Keck, Tobias, Khatkov, Igor, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Azagra, Juan S., Björnsson, Bergthor, Can, Fatih M., D'Hondt, Mathieu, Efanov, Mikhail, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Huscher, Cristiano G.S., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin Young, Liu, Rong, Luyer, Misha D.P., Menon, Krishna, Nakamura, Masafumi, Piardi, Tullio, Saint-Marc, Olivier, White, Steve, Yoon, Yoo Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C.P., Cook, Andrew, Dervenis, Christos, Falconi, Massimo, Ferrari, Clarissa, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Badran, Ali, Baychorov, Magomet, Bannone, Elisa, Van Bodegraven, Eduard A., Emmen, Anouk M.L.H., Giani, Alessandro, De Graaf, Nine, Van Hilst, Jony, Jones, Leia R., Levi Sandri, Giovanni B., Pulvirenti, Alessandra, Ramera, Marco, Rashidian, Niki, Sahakyan, Mushegh A., Uijterwijk, Bas A., Zampedri, Pietro, Zwart, Maurice J.W., Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Portolani, Nazario, Ruzzenente, Andrea, Salvia, Roberto, Siriwardena, Ajith K., Besselink, Marc G., Asbun, Horacio J., Abu Hilal, Mohammad, Van Ramshorst, Tess M.E., Boggi, Ugo, Dokmak, Safi, Edwin, Bjørn, Keck, Tobias, Khatkov, Igor, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Azagra, Juan S., Björnsson, Bergthor, Can, Fatih M., D'Hondt, Mathieu, Efanov, Mikhail, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Huscher, Cristiano G.S., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin Young, Liu, Rong, Luyer, Misha D.P., Menon, Krishna, Nakamura, Masafumi, Piardi, Tullio, Saint-Marc, Olivier, White, Steve, Yoon, Yoo Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C.P., Cook, Andrew, Dervenis, Christos, Falconi, Massimo, Ferrari, Clarissa, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Badran, Ali, Baychorov, Magomet, Bannone, Elisa, Van Bodegraven, Eduard A., Emmen, Anouk M.L.H., Giani, Alessandro, De Graaf, Nine, Van Hilst, Jony, Jones, Leia R., Levi Sandri, Giovanni B., Pulvirenti, Alessandra, Ramera, Marco, Rashidian, Niki, Sahakyan, Mushegh A., Uijterwijk, Bas A., Zampedri, Pietro, Zwart, Maurice J.W., Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Portolani, Nazario, Ruzzenente, Andrea, Salvia, Roberto, Siriwardena, Ajith K., Besselink, Marc G., and Asbun, Horacio J.
Abstract: Objective: To develop and update evidence-based and consensus-based guidelines on laparoscopic and robotic pancreatic surgery. Summary Background Data: Minimally invasive pancreatic surgery (MIPS), including laparoscopic and robotic surgery, is complex and technically demanding. Minimizing the risk for patients requires stringent, evidence-based guidelines. Since the International Miami Guidelines on MIPS in 2019, new developments and key publications have been reported, necessitating an update. Methods: Evidence-based guidelines on 22 topics in 8 domains were proposed: terminology, indications, patients, procedures, surgical techniques and instrumentation, assessment tools, implementation and training, and artificial intelligence. The Brescia Internationally Validated European Guidelines on Minimally Invasive Pancreatic Surgery (EGUMIPS, September 2022) used the Scottish Intercollegiate Guidelines Network (SIGN) methodology to assess the evidence and develop guideline recommendations, the Delphi method to establish consensus on the recommendations among the Expert Committee, and the AGREE II-GRS tool for guideline quality assessment and external validation by a Validation Committee. Results: Overall, 27 European experts, 6 international experts, 22 international Validation Committee members, 11 Jury Committee members, 18 Research Committee members, and 121 registered attendees of the 2-day meeting were involved in the development and validation of the guidelines. In total, 98 recommendations were developed, including 33 on laparoscopic, 34 on robotic, and 31 on general MIPS, covering 22 topics in 8 domains. Out of 98 recommendations, 97 reached at least 80% consensus among the experts and congress attendees, and all recommendations were externally validated by the Validation Committee. Conclusions: The EGUMIPS evidence-based guidelines on laparoscopic and robotic MIPS can be applied in current clinical practice to provide guidance to patients, surgeons, policy-m
Published: 2024

3. Standardizing definitions and terminology of left-sided pancreatic resections through an international Delphi consensus

Author: van Ramshorst, Tess M. E., van Hilst, Jony, Boggi, Ugo, Dokmak, Safi, Edwin, Bjorn, Keck, Tobias, Khatkov, Igor, Balduzzi, Alberto, Pulvirenti, Alessandra, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Ausania, Fabio, Azagra, Juan S., Balzano, Gianpaolo, Björnsson, Bergthor, Can, Fatih M., Cillo, Umberto, D'Hondt, Mathieu, Efanov, Mikhail, Erkan, Mert, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin-Young, Kleive, Dyre, Kooby, David A., Luyer, Misha D. P., Marchegiani, Giovanni, Menon, Krishna, Molenaar, I. Quintus, Nagakawa, Yuichi, Nakamura, Masafumi, Palumbo, Diego, Piardi, Tullio, Ramia, Jose M., Saint-Marc, Olivier, Salti, George I, Strobel, Oliver, Vollmer, Charles M., Wei, Alice C., White, Steve, Yoon, Yoo-Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C. P., Dervenis, Christos, Falconi, Massimo, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Casadei, Riccardo, Coppola, Roberto, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Pietrabissa, Andrea, Portolani, Nazario, Salvia, Roberto, Siriwardena, Ajith K., Asbun, Horacio J., Besselink, Marc G., Abu Hilal, Mohammad, van Ramshorst, Tess M. E., van Hilst, Jony, Boggi, Ugo, Dokmak, Safi, Edwin, Bjorn, Keck, Tobias, Khatkov, Igor, Balduzzi, Alberto, Pulvirenti, Alessandra, Ahmad, Jawad, Al Saati, Hani, Alseidi, Adnan, Ausania, Fabio, Azagra, Juan S., Balzano, Gianpaolo, Björnsson, Bergthor, Can, Fatih M., Cillo, Umberto, D'Hondt, Mathieu, Efanov, Mikhail, Erkan, Mert, Espin Alvarez, Francisco, Esposito, Alessandro, Ferrari, Giovanni, Groot Koerkamp, Bas, Gumbs, Andrew A., Hogg, Melissa E., Ielpo, Benedetto, Ivanecz, Arpad, Jang, Jin-Young, Kleive, Dyre, Kooby, David A., Luyer, Misha D. P., Marchegiani, Giovanni, Menon, Krishna, Molenaar, I. Quintus, Nagakawa, Yuichi, Nakamura, Masafumi, Palumbo, Diego, Piardi, Tullio, Ramia, Jose M., Saint-Marc, Olivier, Salti, George I, Strobel, Oliver, Vollmer, Charles M., Wei, Alice C., White, Steve, Yoon, Yoo-Seok, Zerbi, Alessandro, Bassi, Claudio, Berrevoet, Frederik, Chan, Carlos, Coimbra, Felipe J., Conlon, Kevin C. P., Dervenis, Christos, Falconi, Massimo, Frigerio, Isabella, Fusai, Giuseppe K., De Oliveira, Michelle L., Pinna, Antonio D., Primrose, John N., Sauvanet, Alain, Serrablo, Alejandro, Smadi, Sameer, Alfieri, Sergio, Berti, Stefano, Butturini, Giovanni, Casadei, Riccardo, Coppola, Roberto, Di Benedetto, Fabrizio, Ettorre, Giuseppe M., Giuliante, Felice, Jovine, Elio, Memeo, Riccardo, Pietrabissa, Andrea, Portolani, Nazario, Salvia, Roberto, Siriwardena, Ajith K., Asbun, Horacio J., Besselink, Marc G., and Abu Hilal, Mohammad
Abstract: Funding Agencies|Intuitive grant for the LEARNBOT European Robotic Pancreatoduodenectomy training programme; DIPLOMA-2 trial; E-MIPS Registry; Medtronic grant for the investigator-initiated DIPLOMA trial; Ethicon grant for the PANDORINA trial; Intuitive for robotic pancreatoduodenectomy training
Published: 2024
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4. Magnetosphere-Ionosphere-Thermosphere Coupling Study at Jupiter Based on Juno's First 30 Orbits and Modeling Tools

Author: Al Saati, S., Clement, N., Louis, C., Blanc, M., Wang, Y., Andre, N., Lamy, L., Bonfond, B., Collet, B., Allegrini, F., Bolton, S., Clark, G., Connerney, J. E. P., Gerard, J-C, Gladstone, G. R., Kotsiaros, S., Kurth, W. S., Mauk, B., Al Saati, S., Clement, N., Louis, C., Blanc, M., Wang, Y., Andre, N., Lamy, L., Bonfond, B., Collet, B., Allegrini, F., Bolton, S., Clark, G., Connerney, J. E. P., Gerard, J-C, Gladstone, G. R., Kotsiaros, S., Kurth, W. S., and Mauk, B.
Abstract: The dynamics of the Jovian magnetosphere is controlled by the interplay of the planet's fast rotation, its solar-wind interaction and its main plasma source at the Io torus, mediated by coupling processes involving its magnetosphere, ionosphere, and thermosphere. At the ionospheric level, these processes can be characterized by a set of parameters including conductances, field-aligned currents, horizontal currents, electric fields, transport of charged particles along field lines including the fluxes of electrons precipitating into the upper atmosphere which trigger auroral emissions, and the particle and Joule heating power dissipation rates into the upper atmosphere. Determination of these key parameters makes it possible to estimate the net transfer of momentum and energy between Jovian upper atmosphere and equatorial magnetosphere. A method based on a combined use of Juno multi-instrument data and three modeling tools was developed by Wang et al. (2021, ) and applied to an analysis of the first nine orbits to retrieve these parameters along Juno's magnetic footprint. We extend this method to the first 30 Juno science orbits and to both hemispheres. Our results reveal a large variability of these parameters from orbit to orbit and between the two hemispheres. They also show dominant trends. Southern current systems are consistent with the generation of a region of sub-corotating ionospheric plasma flows, while both super-corotating and sub-corotating plasma flows are found in the north. These results are discussed in light of the previous space and ground-based observations and currently available models of plasma convection and current systems, and their implications are assessed.
Published: 2022

5. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.

Author: Hanemaaijer, ES, Margaritis, T, Sanders, K, Bos, FL, Candelli, T, Al-Saati, H, van, Noesel MM, Meyer-Wentrup, FAG, van, de Wetering M, Holstege, FCP, Clevers, H, Hanemaaijer, ES, Margaritis, T, Sanders, K, Bos, FL, Candelli, T, Al-Saati, H, van, Noesel MM, Meyer-Wentrup, FAG, van, de Wetering M, Holstege, FCP, and Clevers, H
Abstract: Neuroblastoma is the most common extracranial solid tumor and accounts for ∼10% of pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is generally accepted that neuroblastoma derives from the neural crest and should thus be considered an embryonal malignancy. About 50% of primary neuroblastoma tumors arise in the adrenal gland. Here, we present an atlas of the developing mouse adrenal gland at a single-cell level. Five main cell cluster groups (medulla, cortex, endothelial, stroma, and immune) make up the mouse adrenal gland during fetal development. The medulla group, which is of neural crest origin, is further divided into seven clusters. Of interest is the Schwann cell precursor (“SCP”) and the “neuroblast” cluster, a highly cycling cluster that shares markers with sympathoblasts. The signature of the medullary SCP cluster differentiates neuroblastoma patients based on disease phenotype: The SCP signature score anticorrelates with ALK and MYCN expression, two indicators of poor prognosis. Furthermore, a high SCP signature score is associated with better overall survival rates. This study provides an insight into the developing adrenal gland and introduces the SCP gene signature as being of interest for further research in understanding neuroblastoma phenotype.
Published: 2021

6. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.

Author: Interne geneeskunde GD, dCSCA AVR, dCSCA RMSC-2, Faculteit Diergeneeskunde, CS_Cancer, Hanemaaijer, ES, Margaritis, T, Sanders, K, Bos, FL, Candelli, T, Al-Saati, H, van, Noesel MM, Meyer-Wentrup, FAG, van, de Wetering M, Holstege, FCP, Clevers, H, Interne geneeskunde GD, dCSCA AVR, dCSCA RMSC-2, Faculteit Diergeneeskunde, CS_Cancer, Hanemaaijer, ES, Margaritis, T, Sanders, K, Bos, FL, Candelli, T, Al-Saati, H, van, Noesel MM, Meyer-Wentrup, FAG, van, de Wetering M, Holstege, FCP, and Clevers, H
Published: 2021

7. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype

Author: Hanemaaijer, Evelyn S, Margaritis, Thanasis, Sanders, Karin, Bos, Frank L, Candelli, Tito, Al-Saati, Hanin, van Noesel, Max M, Meyer-Wentrup, Friederike A G, van de Wetering, Marc, Holstege, Frank C P, Clevers, Hans, Hanemaaijer, Evelyn S, Margaritis, Thanasis, Sanders, Karin, Bos, Frank L, Candelli, Tito, Al-Saati, Hanin, van Noesel, Max M, Meyer-Wentrup, Friederike A G, van de Wetering, Marc, Holstege, Frank C P, and Clevers, Hans
Abstract: Neuroblastoma is the most common extracranial solid tumor and accounts for ∼10% of pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is generally accepted that neuroblastoma derives from the neural crest and should thus be considered an embryonal malignancy. About 50% of primary neuroblastoma tumors arise in the adrenal gland. Here, we present an atlas of the developing mouse adrenal gland at a single-cell level. Five main cell cluster groups (medulla, cortex, endothelial, stroma, and immune) make up the mouse adrenal gland during fetal development. The medulla group, which is of neural crest origin, is further divided into seven clusters. Of interest is the Schwann cell precursor ("SCP") and the "neuroblast" cluster, a highly cycling cluster that shares markers with sympathoblasts. The signature of the medullary SCP cluster differentiates neuroblastoma patients based on disease phenotype: The SCP signature score anticorrelates with ALK and MYCN expression, two indicators of poor prognosis. Furthermore, a high SCP signature score is associated with better overall survival rates. This study provides an insight into the developing adrenal gland and introduces the SCP gene signature as being of interest for further research in understanding neuroblastoma phenotype.
Published: 2021

8. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.

Author: Interne geneeskunde GD, dCSCA AVR, dCSCA RMSC-2, Faculteit Diergeneeskunde, CS_Cancer, Hanemaaijer, ES, Margaritis, T, Sanders, K, Bos, FL, Candelli, T, Al-Saati, H, van, Noesel MM, Meyer-Wentrup, FAG, van, de Wetering M, Holstege, FCP, Clevers, H, Interne geneeskunde GD, dCSCA AVR, dCSCA RMSC-2, Faculteit Diergeneeskunde, CS_Cancer, Hanemaaijer, ES, Margaritis, T, Sanders, K, Bos, FL, Candelli, T, Al-Saati, H, van, Noesel MM, Meyer-Wentrup, FAG, van, de Wetering M, Holstege, FCP, and Clevers, H
Published: 2021

9. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.

Author: Interne geneeskunde GD, dCSCA AVR, dCSCA RMSC-2, Faculteit Diergeneeskunde, CS_Cancer, Hanemaaijer, ES, Margaritis, T, Sanders, K, Bos, FL, Candelli, T, Al-Saati, H, van, Noesel MM, Meyer-Wentrup, FAG, van, de Wetering M, Holstege, FCP, Clevers, H, Interne geneeskunde GD, dCSCA AVR, dCSCA RMSC-2, Faculteit Diergeneeskunde, CS_Cancer, Hanemaaijer, ES, Margaritis, T, Sanders, K, Bos, FL, Candelli, T, Al-Saati, H, van, Noesel MM, Meyer-Wentrup, FAG, van, de Wetering M, Holstege, FCP, and Clevers, H
Published: 2021

10. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype

Author: Hanemaaijer, Evelyn S, Margaritis, Thanasis, Sanders, Karin, Bos, Frank L, Candelli, Tito, Al-Saati, Hanin, van Noesel, Max M, Meyer-Wentrup, Friederike A G, van de Wetering, Marc, Holstege, Frank C P, Clevers, Hans, Hanemaaijer, Evelyn S, Margaritis, Thanasis, Sanders, Karin, Bos, Frank L, Candelli, Tito, Al-Saati, Hanin, van Noesel, Max M, Meyer-Wentrup, Friederike A G, van de Wetering, Marc, Holstege, Frank C P, and Clevers, Hans
Abstract: Neuroblastoma is the most common extracranial solid tumor and accounts for ∼10% of pediatric cancer-related deaths. The exact cell of origin has yet to be elucidated, but it is generally accepted that neuroblastoma derives from the neural crest and should thus be considered an embryonal malignancy. About 50% of primary neuroblastoma tumors arise in the adrenal gland. Here, we present an atlas of the developing mouse adrenal gland at a single-cell level. Five main cell cluster groups (medulla, cortex, endothelial, stroma, and immune) make up the mouse adrenal gland during fetal development. The medulla group, which is of neural crest origin, is further divided into seven clusters. Of interest is the Schwann cell precursor ("SCP") and the "neuroblast" cluster, a highly cycling cluster that shares markers with sympathoblasts. The signature of the medullary SCP cluster differentiates neuroblastoma patients based on disease phenotype: The SCP signature score anticorrelates with ALK and MYCN expression, two indicators of poor prognosis. Furthermore, a high SCP signature score is associated with better overall survival rates. This study provides an insight into the developing adrenal gland and introduces the SCP gene signature as being of interest for further research in understanding neuroblastoma phenotype.
Published: 2021

11. Venous thromboembolism prevention protocol for adapting prophylaxis recommendations to the potential risk post total knee replacement: a randomized controlled trial

Author: Alameri, Mariam A., Syed Sulaiman, Syed A., Ashour, Abdykkah M., Al-Saati, Ma'ad F., Alameri, Mariam A., Syed Sulaiman, Syed A., Ashour, Abdykkah M., and Al-Saati, Ma'ad F.
Abstract: Background: Total knee replacement (TKR) is a major orthopedic surgery that is considered high risk for the development of venous thromboembolism (VTE). Objective: The aim of this study is to evaluate the clinical outcomes that resulted from the use of a new proposed VTE risk stratification protocol for selecting a suitable extended VTE prophylaxis for post TKR surgery patients administered in conjunction with patient education programs. Method: A randomized controlled trial was conducted in two medical centers in Saudi Arabia. A total of 242 patients were enrolled in the study, 121 patients in each group. The experimental group (A) was assessed by using the proposed VTE risk stratification protocol and also took part in patient education programs about TKR and its complications. The control group (B) was assessed by using the 2005 Caprini risk assessment tool and no education programs were given to this group. Both groups were followed for 35 days post operation. Results: The mean age of the participants was 65.86 (SD 8.67) and the majority of them were female 137 (56.6%). The mean body mass index of the study sample was 32.46 (SD 5.51). There were no significant differences between the two groups except for surgery type; the proportion of bilateral TKR in group A was higher than in group B (69/121 (28.5%) vs. 40/121(16.5%), p˂0.05). There were no confirmed pulmonary embolism cases in the study sample and diagnosis of deep-vein thrombosis was confirmed in 12/242 (5.0%) of patients: 1/121 (0.8%) in group A and 11/121 (9.1%) in group B (p˂0.05). The readmission rate for all patients was 2.5% (6/242), all of whom were in group B (p˂0.05). Conclusion: The proposed VTE risk stratification protocol that was applied in conjunction with patient education programs reduced VTE complications and readmission events, post TKR surgery. Trial Registration: ClinicalTrials.gov Identifier: NCT04031859.
Published: 2020

12. A Comparative Study on Parameter Estimation in Software Reliability Modeling using Swarm Intelligence

Author: AL-Saati, Najla Akram, Alabajee, Marrwa Abd-AlKareem, AL-Saati, Najla Akram, and Alabajee, Marrwa Abd-AlKareem
Abstract: This work focuses on a comparison between the performances of two well-known Swarm algorithms: Cuckoo Search (CS) and Firefly Algorithm (FA), in estimating the parameters of Software Reliability Growth Models. This study is further reinforced using Particle Swarm Optimization (PSO) and Ant Colony Optimization (ACO). All algorithms are evaluated according to real software failure data, the tests are performed and the obtained results are compared to show the performance of each of the used algorithms. Furthermore, CS and FA are also compared with each other on bases of execution time and iteration number. Experimental results show that CS is more efficient in estimating the parameters of SRGMs, and it has outperformed FA in addition to PSO and ACO for the selected Data sets and employed models., Comment: 7 pages
Published: 2020

13. Applying Gene Expression Programming for Solving One-Dimensional Bin-Packing Problems

Author: Al-Saati, Najla Akram and Al-Saati, Najla Akram
Abstract: This work aims to study and explore the use of Gene Expression Programming (GEP) in solving the on-line Bin-Packing problem. The main idea is to show how GEP can automatically find acceptable heuristic rules to solve the problem efficiently and economically. One dimensional Bin-Packing problem is considered in the course of this work with the constraint of minimizing the number of bins filled with the given pieces. Experimental Data includes instances of benchmark test data taken from Falkenauer (1996) for One-dimensional Bin-Packing Problems. Results show that GEP can be used as a very powerful and flexible tool for finding interesting compact rules suited for the problem. The impact of functions is also investigated to show how they can affect and influence the success of rates when they appear in rules. High success rates are gained with smaller population size and fewer generations compared to previous work performed using Genetic Programming., Comment: 20 page
Published: 2020

14. Selecting Best Software Reliability Growth Models: A Social Spider Algorithm based Approach

Author: AL-Saati, Najla Akram, Alabajee, Marrwa Abd-AlKareem, AL-Saati, Najla Akram, and Alabajee, Marrwa Abd-AlKareem
Abstract: Software Reliability is considered to be an essential part of software systems; it involves measuring the system's probability of having failures; therefore, it is strongly related to Software Quality. Software Reliability Growth Models are used to indicate the expected number of failures encountered after the software has been completed, it is also an indicator of the software readiness to be delivered. This paper presents a study of selecting the best Software Reliability Growth Model according to the dataset at hand. Several Comparison Criteria are used to yield a ranking methodology to be used in pointing out best models. The Social Spider Algorithm SSA, one of the newly introduced Swarm Intelligent Algorithms, is used for estimating the parameters of the SRGMs for two datasets. Results indicate that the use of SSA was efficient in assisting the process of criteria weighting to find the optimal model and the best overall ranking of employed models., Comment: 9 pages
Published: 2020
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15. Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages.

Author: Souriant, Shanti, Souriant, Shanti, Balboa, Luciana, Dupont, Maeva, Pingris, Karine, Kviatcovsky, Denise, Cougoule, Céline, Lastrucci, Claire, Bah, Aicha, Gasser, Romain, Poincloux, Renaud, Raynaud-Messina, Brigitte, Al Saati, Talal, Inwentarz, Sandra, Poggi, Susana, Moraña, Eduardo Jose, González-Montaner, Pablo, Corti, Marcelo, Lagane, Bernard, Vergne, Isabelle, Allers, Carolina, Kaushal, Deepak, Kuroda, Marcelo J, Sasiain, Maria Del Carmen, Neyrolles, Olivier, Maridonneau-Parini, Isabelle, Lugo-Villarino, Geanncarlo, Vérollet, Christel, Souriant, Shanti, Souriant, Shanti, Balboa, Luciana, Dupont, Maeva, Pingris, Karine, Kviatcovsky, Denise, Cougoule, Céline, Lastrucci, Claire, Bah, Aicha, Gasser, Romain, Poincloux, Renaud, Raynaud-Messina, Brigitte, Al Saati, Talal, Inwentarz, Sandra, Poggi, Susana, Moraña, Eduardo Jose, González-Montaner, Pablo, Corti, Marcelo, Lagane, Bernard, Vergne, Isabelle, Allers, Carolina, Kaushal, Deepak, Kuroda, Marcelo J, Sasiain, Maria Del Carmen, Neyrolles, Olivier, Maridonneau-Parini, Isabelle, Lugo-Villarino, Geanncarlo, and Vérollet, Christel
Abstract: The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using in vitro and ex vivo cell culture systems, we show that human M(IL-10) anti-inflammatory macrophages, present in TB-associated microenvironment, produce high levels of HIV-1. In vivo, M(IL-10) macrophages are expanded in lungs of co-infected non-human primates, which correlates with disease severity. Furthermore, HIV-1/Mtb co-infected patients display an accumulation of M(IL-10) macrophage markers (soluble CD163 and MerTK). These M(IL-10) macrophages form direct cell-to-cell bridges, which we identified as tunneling nanotubes (TNTs) involved in viral transfer. TNT formation requires the IL-10/STAT3 signaling pathway, and targeted inhibition of TNTs substantially reduces the enhancement of HIV-1 cell-to-cell transfer and overproduction in M(IL-10) macrophages. Our study reveals that TNTs facilitate viral transfer and amplification, thereby promoting TNT formation as a mechanism to be explored in TB/AIDS potential therapeutics.
Published: 2019

16. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis : Fundamentals Of Care for UveitiS (FOCUS) Initiative

Author: Dick, Andrew D., Rosenbaum, James T., Al-Dhibi, Hassan A., Belfort, Rubens, Brézin, Antoine P., Chee, Soon Phaik, Davis, Janet L., Ramanan, Athimalaipet V., Sonoda, Koh Hei, Carreño, Ester, Nascimento, Heloisa, Salah, Sawsen, Salek, Sherveen, Siak, Jay, Steeples, Laura, Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Alsabaani, Nasser, Al-Shamarani, Mohamed, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Porto, Fernanda Belga Ottoni, Blanco, Ricardo, Yee, Anita Chan Sook, Chandran, Vinod, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Eurico da Fonseca, João, de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Merino, Claudia Eugenia Duran, Facsko, Andrea, Figueira, Luis, Fonollosa, Alejandro, Rothova, Aniki, Fundamentals of Care for Uveitis International Consensus Group, Dick, Andrew D., Rosenbaum, James T., Al-Dhibi, Hassan A., Belfort, Rubens, Brézin, Antoine P., Chee, Soon Phaik, Davis, Janet L., Ramanan, Athimalaipet V., Sonoda, Koh Hei, Carreño, Ester, Nascimento, Heloisa, Salah, Sawsen, Salek, Sherveen, Siak, Jay, Steeples, Laura, Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Alsabaani, Nasser, Al-Shamarani, Mohamed, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Porto, Fernanda Belga Ottoni, Blanco, Ricardo, Yee, Anita Chan Sook, Chandran, Vinod, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Eurico da Fonseca, João, de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Merino, Claudia Eugenia Duran, Facsko, Andrea, Figueira, Luis, Fonollosa, Alejandro, Rothova, Aniki, and Fundamentals of Care for Uveitis International Consensus Group
Published: 2018

17. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis : Fundamentals Of Care for UveitiS (FOCUS) Initiative

Author: Dick, Andrew D., Rosenbaum, James T., Al-Dhibi, Hassan A., Belfort, Rubens, Brézin, Antoine P., Chee, Soon Phaik, Davis, Janet L., Ramanan, Athimalaipet V., Sonoda, Koh Hei, Carreño, Ester, Nascimento, Heloisa, Salah, Sawsen, Salek, Sherveen, Siak, Jay, Steeples, Laura, Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Alsabaani, Nasser, Al-Shamarani, Mohamed, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Porto, Fernanda Belga Ottoni, Blanco, Ricardo, Yee, Anita Chan Sook, Chandran, Vinod, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Eurico da Fonseca, João, de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Merino, Claudia Eugenia Duran, Facsko, Andrea, Figueira, Luis, Fonollosa, Alejandro, Rothova, Aniki, Fundamentals of Care for Uveitis International Consensus Group, Dick, Andrew D., Rosenbaum, James T., Al-Dhibi, Hassan A., Belfort, Rubens, Brézin, Antoine P., Chee, Soon Phaik, Davis, Janet L., Ramanan, Athimalaipet V., Sonoda, Koh Hei, Carreño, Ester, Nascimento, Heloisa, Salah, Sawsen, Salek, Sherveen, Siak, Jay, Steeples, Laura, Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Alsabaani, Nasser, Al-Shamarani, Mohamed, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Porto, Fernanda Belga Ottoni, Blanco, Ricardo, Yee, Anita Chan Sook, Chandran, Vinod, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Eurico da Fonseca, João, de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Merino, Claudia Eugenia Duran, Facsko, Andrea, Figueira, Luis, Fonollosa, Alejandro, Rothova, Aniki, and Fundamentals of Care for Uveitis International Consensus Group
Published: 2018

18. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis : Fundamentals Of Care for UveitiS (FOCUS) Initiative

Author: Dick, Andrew D., Rosenbaum, James T., Al-Dhibi, Hassan A., Belfort, Rubens, Brézin, Antoine P., Chee, Soon Phaik, Davis, Janet L., Ramanan, Athimalaipet V., Sonoda, Koh Hei, Carreño, Ester, Nascimento, Heloisa, Salah, Sawsen, Salek, Sherveen, Siak, Jay, Steeples, Laura, Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Alsabaani, Nasser, Al-Shamarani, Mohamed, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Porto, Fernanda Belga Ottoni, Blanco, Ricardo, Yee, Anita Chan Sook, Chandran, Vinod, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Eurico da Fonseca, João, de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Merino, Claudia Eugenia Duran, Facsko, Andrea, Figueira, Luis, Fonollosa, Alejandro, Rothova, Aniki, Fundamentals of Care for Uveitis International Consensus Group, Dick, Andrew D., Rosenbaum, James T., Al-Dhibi, Hassan A., Belfort, Rubens, Brézin, Antoine P., Chee, Soon Phaik, Davis, Janet L., Ramanan, Athimalaipet V., Sonoda, Koh Hei, Carreño, Ester, Nascimento, Heloisa, Salah, Sawsen, Salek, Sherveen, Siak, Jay, Steeples, Laura, Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Alsabaani, Nasser, Al-Shamarani, Mohamed, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Porto, Fernanda Belga Ottoni, Blanco, Ricardo, Yee, Anita Chan Sook, Chandran, Vinod, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Eurico da Fonseca, João, de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Merino, Claudia Eugenia Duran, Facsko, Andrea, Figueira, Luis, Fonollosa, Alejandro, Rothova, Aniki, and Fundamentals of Care for Uveitis International Consensus Group
Published: 2018

19. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative

Author: MS Oogheelkunde, Infection & Immunity, Zorgeenheid Oogheelkunde Medisch, Dick, Andrew D., Rosenbaum, James T., Al-Dhibi, Hassan A., Belfort, Rubens, Brézin, Antoine P., Chee, Soon Phaik, Davis, Janet L., Ramanan, Athimalaipet V., Sonoda, Koh Hei, Carreño, Ester, Nascimento, Heloisa, Salah, Sawsen, Salek, Sherveen, Siak, Jay, Steeples, Laura, Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Alsabaani, Nasser, Al-Shamarani, Mohamed, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Porto, Fernanda Belga Ottoni, Blanco, Ricardo, Yee, Anita Chan Sook, Chandran, Vinod, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Eurico da Fonseca, João, de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Merino, Claudia Eugenia Duran, Facsko, Andrea, Figueira, Luis, Fonollosa, Alejandro, Rothova, Aniki, Fundamentals of Care for Uveitis International Consensus Group, MS Oogheelkunde, Infection & Immunity, Zorgeenheid Oogheelkunde Medisch, Dick, Andrew D., Rosenbaum, James T., Al-Dhibi, Hassan A., Belfort, Rubens, Brézin, Antoine P., Chee, Soon Phaik, Davis, Janet L., Ramanan, Athimalaipet V., Sonoda, Koh Hei, Carreño, Ester, Nascimento, Heloisa, Salah, Sawsen, Salek, Sherveen, Siak, Jay, Steeples, Laura, Accorinti, Massimo, Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Alsabaani, Nasser, Al-Shamarani, Mohamed, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Porto, Fernanda Belga Ottoni, Blanco, Ricardo, Yee, Anita Chan Sook, Chandran, Vinod, Chiquet, Christophe, Chng, Hiok Hee, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Cristobal, Couto, Cuevas, Miguel, Eurico da Fonseca, João, de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Merino, Claudia Eugenia Duran, Facsko, Andrea, Figueira, Luis, Fonollosa, Alejandro, Rothova, Aniki, and Fundamentals of Care for Uveitis International Consensus Group
Published: 2018

20. Using Multi Expression Programming in Software Effort Estimation

Author: Akram, Najla, AL-Saati, Alreffaee, Taghreed Riyadh, Akram, Najla, AL-Saati, and Alreffaee, Taghreed Riyadh
Abstract: Estimating the effort of software systems is an essential topic in software engineering, carrying out an estimation process reliably and accurately for a software forms a vital part of the software development phases. Many researchers have utilized different methods and techniques hopping to find solutions to this issue, such techniques include COCOMO, SEER-SEM,SLIM and others. Recently, Artificial Intelligent techniques are being utilized to solve such problems; different studies have been issued focusing on techniques such as Neural Networks NN, Genetic Algorithms GA, and Genetic Programming GP. This work uses one of the linear variations of GP, namely: Multi Expression Programming (MEP) aiming to find the equation that best estimates the effort of software. Benchmark datasets (based on previous projects) are used learning and testing. Results are compared with those obtained by GP using different fitness functions. Results show that MEP is far better in discovering effective functions for the estimation of about 6 datasets each comprising several projects.
Published: 2018

21. Laparoscopic radical 'no-touch' left pancreatosplenectomy for pancreatic ductal adenocarcinoma : technique and results.

Author: Abu Hilal, M, Richardson, J R C, de Rooij, T, Dimovska, Eleonora, Al-Saati, H, Besselink, M G, Abu Hilal, M, Richardson, J R C, de Rooij, T, Dimovska, Eleonora, Al-Saati, H, and Besselink, M G
Abstract: BACKGROUND: Laparoscopic left pancreatectomy has been well described for benign pancreatic lesions, but its role in pancreatic adenocarcinoma remains open to debate. We report our results adopting a laparoscopic technique that obeys established oncologic principles of open distal pancreatosplenectomy. METHODS: This is a post hoc analysis of a prospectively kept database of 135 consecutive patients undergoing laparoscopic left pancreatectomy, performed across two sites in the UK and the Netherlands (07/2007-07/2015 Southampton and 10/2013-07/2015 Amsterdam). Primary outcomes were resection margin and lymph node retrieval. Secondary endpoints were other perioperative outcomes, including post-operative pancreatic fistula. Definition of radical resection was distance tumour to resection margin >1 mm. All patients underwent 'laparoscopic radical left pancreatosplenectomy' (LRLP) which involves 'hanging' the pancreas including Gerota's fascia, followed by clockwise dissection, including formal lymphadenectomy. RESULTS: LRLP for pancreatic adenocarcinoma was performed in 25 patients. Seven of the 25 patients (28 %) had extended resections, including the adrenal gland (n = 3), duodenojejunal flexure (n = 2) or transverse mesocolon (n = 3). Mean age was 68 years (54-81). Conversion rate was 0 %, mean operative time 240 min and mean blood loss 340 ml. Median intensive/high care and hospital stay were 1 and 5 days, respectively. Clavien-Dindo score 3+ complication rate was 12 % and ISGPF grade B/C pancreatic fistula rate 28 %; 90-day (or in-hospital) mortality was 0 %. The pancreatic resection margin was clear in all patients, and the posterior margin was involved (<1 mm) in 6 patients, meaning an overall R0 resection rate of 76 %. No resection margin was microscopically involved. Median nodal sample was 15 nodes (3-26). With an average follow-up of 17.2 months, 1-year survival was 88 %. CONCLUSIONS: A standardised laparoscopic approach to pancreatic adenocarcinoma in th
Published: 2016
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22. Intracerebral hemorrhage in ICU: is it worth treating?

Author: Sivakumar, S, Taccone, F, Desai, K, Lazaridis, C, Skarzynski, M, Sekhon, M, Henderson, W, Griesdale, D, Chapple, L, Deane, A, Williams, L, Strickland, R, Lange, K, Heyland, D, Chapman, M, Rowland, M, Garry, P, Westbrook, J, Corkill, R, Antoniades, C, Pattinson, K, Fatania, G, Strong, A, Myers, R, Jermaine, C, Robertson, C, Rusin, C, Hofmeijer, J, Sondag, L, Tjepkema Cloostermans, M, Beishuizen, A, Bosch, F, van Putten, M, Carteron, L, Patet, C, Solari, D, Oddo, M, Ali, M, Dias, C, Almeida, R, Vaz Ferreira, A, Silva, J, Monteiro, E, Cerejo, A, Rocha, A, Elsayed, A, Abougabal, A, Beshey, B, Alzahaby, K, Pozzebon, S, Ortiz, A, Cristallini, S, Lheureux, O, Brasseur, A, Vincent, J, Creteur, J, Hravnak, M, Yousef, K, Chang, Y, Crago, E, Friedlander, R, Abdelmonem, S, Tahon, S, Helmy, T, Meligy, H, Puig, F, Dunn Siegrist, I, Pugin, J, Gupta, S, Govil, D, Srinivasan, S, Patel, S, N, J, Gupta, A, Tomar, D, Shafi, M, Harne, R, Arora, D, Talwar, N, Mazumdar, S, Papakrivou, E, Makris, D, Manoulakas, E, Tsolaki, B, Karadodas, B, Zakynthinos, E, Garcia, I, Martin, A, Encinares, V, Ibañez, M, Montero, J, Labrador, G, Cangueiro, T, Poulose, V, Koh, J, Kam, J, Yeter, H, Kara, A, Aktepe, O, Topeli, A, Tsolakoglou, I, Intas, G, Stergiannis, P, Kolaros, A, Chalari, E, Athanasiadou, E, Martika, A, Fildisis, G, Faivre, V, Mengelle, C, Favier, B, Payen, D, Poppe, A, Winkler, M, Mudersbach, E, Schreiber, J, Wruck, M, Schwedhelm, E, Kluge, S, Zöllner, C, Tavladaki, T, Spanaki, A, Dimitriou, H, Kondili, E, Choulaki, C, Meleti, E, Kafetzopoulos, D, Georgopoulos, D, Briassoulis, G, la Torre, A, de la Torre Prados, M, Tsvetanova Spasova, T, Nuevo Ortega, P, Rueda Molina, C, Fernández Porcel, A, Camara Sola, E, Salido Díaz, L, García Alcántara, A, Meleti, D, Suberviola, B, Riera, J, Rellan, L, Sanchez, M, Robles, J, Lopez, E, Vicente, R, Miñambres, E, Santibañez, M, Le Guen, M, Moore, J, Mason, N, Windpassinger, M, Plattner, O, Mascha, E, Sessler, D, Research, O, Melia, U, Fontanet, J, van den Berg, J, Struys, M, Vereecke, H, Jensen, E, Rood, P, van de Schoor, F, van Tertholen, K, Pickkers, P, van den Boogaard, M, Beardow, Z, Redhead, H, Paramasivam, K, Numan, T, Kamper, A, Peelen, L, Zeman, P, Slooter, A, van Ewijk, C, Jacobs, G, Girbes, A, Myatra, S, Harish, M, Prabu, N, Siddiqui, S, Kulkarni, A, Divatia, J, Murbach, L, Leite, M, Osaku, E, Costa, C, Pelenz, M, Neitzke, N, Moraes, M, Jaskowiak, J, Silva, M, Zaponi, R, Abentroth, L, Ogasawara, S, Jorge, A, Duarte, P, Hernández Sánchez, N, Sánchez Hurtado, L, García Guillen, F, Ñamendys Silva, S, Maghsoudi, B, Emami, M, Khosravi, M, Zand, F, Tabatabaie, H, Masjedi, M, Sabetiyan, G, Mokri, A, Troubleyn, J, Diltoer, M, Jacobs, R, Nguyen, D, De Waele, E, De Regt, J, Honoré, P, Van Gorp, V, Spapen, H, Contreras, R, Toapanta, N, Moreno, G, Sabater, J, Torrado, H, Gonzalez, M, Marin, M, Farigola, E, Gonzalez, A, Fernandez, J, Vera, A, Gisbert, X, Juliá, C, Uya, J, Corral, L, Elias Jones, I, Gemmell, L, Mackay, A, Randall, D, Adwaney, A, Blunden, M, Prowle, J, Kirwan, C, Thomas, N, Owen, H, Darwin, L, Conway, D, Atkinson, D, Sharman, M, Barbanti, C, Amour, J, Gaudard, P, Rozec, B, Mauriat, P, M'Rini, M, Leger, P, Cambonie, G, Liet, J, Girard, C, Laroche, S, Damas, P, Assaf, Z, Loron, G, Lecourt, L, Pouard, P, Kim, S, Na, S, Kim, J, Oh, S, Jung, C, Yoo, S, Min, S, Chung, E, Lee, H, Lee, N, Lee, K, Suh, K, Ryu, H, Marshall, D, Goodson, R, Salciccioli, J, Shalhoub, J, Potter, E, Kirk Bayley, J, Karanjia, N, Forni, L, Creagh Brown, B, Bossy, M, Nyman, M, Tailor, A, D'Antini, D, Spadaro, S, Valentino, F, Sollitto, F, Cinnella, G, Mirabella, L, Calvo, F, Bejarano, N, Padilla, D, Baladron, V, Villajero, P, Villazala, R, Redondo, J, Yuste, A, Liu, J, Shen, F, Teboul, J, Anguel, N, Beurton, A, Bezaz, N, Richard, C, Monnet, X, Fossali, T, Colombo, R, Ottolina, D, Rossetti, M, Mazzucco, C, Marchi, A, Porta, A, Catena, E, Tollisen, K, Andersen, G, Heyerdahl, F, Jacobsen, D, de Waard, M, van 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Azab, A, El Hossainy, R, Nagy, H, Nirmalan, M, Crippa, I, Cavicchi, F, Chaari, A, Hakim, K, Hassanein, H, Etman, M, El Bahr, M, Bousselmi, K, Khalil, E, Kauts, V, Casey, W, Imahase, H, Sakamoto, Y, Yamada, K, Miike, T, Nagashima, F, Iwamura, T, Boscolo, A, Lucchetta, V, Piasentini, E, Bertini, D, Manesso, L, Spiezia, L, Simioni, P, Ori, C, Souza, R, Martins, A, Liberatore, A, Kang, Y, Nakamae, M, Koh, I, Hanslin, K, Wilske, F, Skorup, P, Sjölin, J, Lipcsey, M, Long, W, Zhen, C, Vakalos, A, Avramidis, V, Wu, S, Shyu, L, Li, C, Yu, C, Chen, H, Wang, C, Lin, K, Aray, Z, Gómez, C, Tejero, A, Monge, D, Losada, V, Tarancón, C, Cortés, S, Gutiérrez, A, Álvarez, T, Rouze, A, Jaffal, K, Six, S, Stolz, K, Cattoen, V, Arnal, J, Saoli, M, Novotni, D, Garnero, A, Becher, T, Buchholz, V, Schädler, D, Frerichs, I, Weiler, N, Eronia, N, Mauri, T, Gatti, S, Maffezzini, E, Bronco, A, Alban, L, Sasso, T, Marenghi, C, Grasselli, G, Pesenti, A, Bellani, G, Al Fares, A, Del Sorbo, L, Anwar, S, Facchin, F, Azad, S, Zamel, R, Cypel, M, Keshavjee, S, Durlinger, E, Spoelstra de Man, A, de Grooth, H, Straaten, H, Alfaro, M, Parrilla, F, Meli, A, Pellegrini, M, Rodriguez, N, Goyeneche, J, Morán, I, Aguirre, H, Mancebo, J, Heines, S, Strauch, U, Bergmans, D, Blankman, P, Shono, A, Hasan, D, Gommers, D, Chung, W, Jung, Y, Park, J, Sheen, S, Park, K, Worral, R, Larraza, S, Dey, N, Brohus, J, Winding, R, Volta, C, Ampatzidou, F, Vlachou, A, Kehagioglou, G, Karaiskos, T, Madesis, A, Mauromanolis, C, Michail, N, Drossos, G, Saraj, N, Rijkenberg, S, Feijen, H, Endeman, H, Donnelly, A, Morgan, E, Garrard, H, Buckley, H, Russell, L, Haase, N, Goh, C, Mouyis, K, Woodward, C, Halliday, J, Encina, G, Ros, J, Lagunes, L, Tabernero, J, Rello, J, Morente Constantin, E, Rivera Ginés, B, Colmenero Ruiz, M, Sanz, J, Simon, I, Valbuena, B, Pais, M, Ramalingam, S, Díaz, C, Fox, L, Santafe, M, Barba, P, García, M, Leal, S, Veganzones, J, Martínez, N, Moors, I, Mokart, D, Pène, F, Lambert, J, Mayaux, J, Vincent, F, Nyunga, M, Bruneel, F, Laisne, L, Rabbat, A, Lebert, C, Perez, P, Chaize, M, Renault, A, Meert, A, Hamidfar, R, Jourdain, M, Darmon, M, Schlemmer, B, Chevret, S, Lemiale, V, Azoulay, E, Benoit, D, Martins Branco, D, Sousa, M, Marum, S, Bouw, M, Galstyan, G, Makarova, P, Parovichnikova, E, Kuzmina, L, Troitskaya, V, Drize, N, Gemdzhian, E, Savchenko, V, Chao, H, Kılıc, E, Demiriz, B, Uygur, M, Sürücü, M, Cınar, K, Yıldırım, A, Kiss, K, Köves, B, Csernus, V, Molnár, Z, Ntantana, A, Matamis, D, Savvidou, S, Giannakou, M, Gouva, M, Nakos, G, Koulouras, V, Gaffney, S, Judge, C, Drew, T, Misran, H, Munshi, R, Mcgovern, L, Coyle, M, Dunne, L, Deasy, E, Lavin, P, Fahy, A, Darcy, D, Donnelly, M, Ismail, N, Hall, T, Wykes, K, Jack, J, Ngu, W, Morgan, P, Ruiz Ramos, J, Ramirez, P, Gordon, M, Villarreal, E, Frasquet, J, Poveda Andrés, J, Castellanos, A, Ijssennagger, C, Ten Hoorn, S, van Wijk, A, van den Broek, J, Tuinman, P, Elmenshawy, A, Hammond, B, Gibbon, G, Belcham, T, Burton, K, Taniguchi, L, Ramos, F, Momma, A, Martins Filho, A, Bartocci, J, Lopes, M, Sad, M, Rodrigues, C, Pires, E, Barreto, J, Duarte, S, Taba, S, Miglioranza, D, Gund, D, Lordani, C, Capuzzo, M, Corte, F, Terranova, S, Scaramuzzo, G, Fogagnolo, A, Bertacchini, S, Bellonzi, A, Ragazzi, R, Cruz, C, Nunes, A, Pereira, F, Aragão, I, Cardoso, A, Santos, C, Malheiro, M, Castro, H, Cardoso, T, Paratz, J, Kenardy, J, Comans, T, Coyer, F, Thomas, P, Boots, R, Pereira, N, Vilas Boas, A, Gomes, E, Torres, J, Carvalho, D, Molinos, E, Vales, C, Araújo, R, Karnatovskaia, L, Philbrick, K, Ognjen, G, Clark, M, Montero, R, Varas, J, Sánchez Elvira, L, Delgado, C, Díaz, P, Ruiz, B, Guerrero, A, Galache, J, Jiménez, R, Rebollo, S, Alejandro, O, Fernández, A, Moreno, S, Herrera, L, Ojados, A, Galindo, M, Murcia, J, Contreras, M, Sánchez Argente, S, Bonilla, Y, Rodríguez, M, Allegue, J, Cakin, Ö, Parlak, H, Kirca, H, Mutlu, F, Aydınlı, B, Cengiz, M, Ramazanoglu, A, Jung, E, Domenech, J, Montalvo, A, Chornet, T, Martinez, P, Ribas, M, Costa, R, Ortega, A, Forbes, C, Prescott, H, Lal, A, Khan, F, Dela Pena, E, Dizon, J, Wong, C, Garach, M, Romero, O, Puerta, R, Diaz, F, Bailon, A, Pinel, A, Maldonado, L, Kalaiselvan, M, Kumar, R, Renuka, M, De Rosa, S, Ferrari, F, Checcacci, S, Rigobello, A, Joannidis, M, Politi, F, Pellizzari, A, Bonato, R, Fernandez Carmona, A, Macias Guarasa, I, Gutierrez Rodriguez, R, Martinez Lopez, P, Diaz Castellanos, M, Arias Diaz, M, Aguilar Alonso, E, Nikandish, R, Artemenko, V, Budnyuk, A, Bassi, G, Senussi, T, Idone, F, Xiol, E, Travierso, C, Chiurazzi, C, Motos, A, Amaro, R, Hua, Y, Fernández Barat, L, Ranzani, O, Bobi, Q, Rigol, M, Youn, A, Hwang, J, Ossorio, M, Figueira, H, Oliveira, R, Mota, A, Kamp, O, Cruciger, O, Aach, M, Kaczmarek, C, Waydhas, C, Schildhauer, T, Hamsen, U, Camprubí Rimblas, M, Chimenti, L, Guillamat Prats, R, Lebouvier, T, Bringué, J, Tijero, J, Gómez, M, Blanch, L, Tagliabue, G, Ji, M, Jagers, J, Easton, P, Hong, J, Shin, M, Park, M, Pomprapa, A, Hofferberth, M, Russ, M, Braun, W, Walter, M, Francis, R, Lachmann, B, Leonhardt, S, Landaverde López, A, Canedo Castillo, N, Esquivel Chávez, A, Arvizu Tachiquín, P, Baltazar Torres, J, Cardoso, V, Krystopchuk, A, Castro, S, Melão, L, Firmino, S, Marreiros, A, Almaziad, S, Kubbara, A, Barnett, W, Nakity, R, Alamoudi, W, Altook, R, Tarazi, T, Fida, M, Safi, F, Assaly, R, Santini, A, Milesi, M, Maraffi, T, Pugni, P, Cavenago, M, Gattinoni, L, Protti, A, Perchiazzi, G, Borges, J, Bayat, S, Porra, L, Broche, L, Hedenstierna, G, Larsson, A, Roneus, A, Segelsjö, M, Vestito, M, Gremo, E, Nyberg, A, Castegren, M, Pikwer, A, Yoshida, T, Engelberts, D, Otulakowski, G, Katira, B, Post, M, Amato, M, Koch, N, Hoellthaler, J, Mair, S, Phillip, V, Beitz, A, Baladrón, V, Villarejo, P, Steenstra, R, Banierink, H, Hof, J, Hoekstra, M, Sterz, F, Horvatits, K, Herkner, H, Kott, M, Zitta, K, Brandt, B, Schildhauer, C, Elke, G, Hummitzsch, L, Albrecht, M, González, L, Alonso, D, Sánchez, R, Lucas, J, Ferlitsch, A, Fauler, G, Trauner, M, Pischke, S, Fischer, L, Thaiss, F, Koch, M, Bangert, K, Lohse, A, Nashan, B, Sterneck, M, Faenza, S, Siniscalchi, A, Pierucci, E, Mancini, E, Ricci, D, Gemelli, C, Cuoghi, A, Magnani, S, Atti, M, Sotos, F, Cánovas, J, López, A, Burruezo, A, Torres, D, Herrera Gutierrez, M, Barrueco Francioni, J, Arias Verdú, D, Lozano Saez, R, Quesada Garcia, G, Seller Pérez, G, Figueiredo, A, Anzola, Y, Pereira, R, Bento, L, Lai, M, Deiana, M, Seller Perez, G, Vardas, K, Ilia, S, Sertedaki, A, Charmadari, E, Stratakis, C, Briassouli, E, Goukos, D, Psarra, K, Botoula, E, Tsagarakis, S, Mageira, E, Routsi, C, Nanas, S, Campello, E, Radu, C, Su, H, Lam, Y, Willis, K, Pullar, V, Hubner, R, Tsang, J, de Guadiana Romualdo, L, Rebollo Acebes, S, Esteban Torrella, P, Jiménez Sánchez, R, Jiménez Santos, E, Ortín Freire, A, Hernando Holgado, A, Albaladejo Otón, M, Coelho, L, Rabello, L, Póvoa, P, Varis, E, Poukkanen, M, Jacob, S, Takala, J, Wilkman, E, Lundberg, O, Bergenzaun, L, Rydén, J, Rosenqvist, M, Melander, O, Chew, M, Kishihara, Y, Yasuda, H, Jimenez, R, Torrella, P, Fernandez, A, Sanchez, S, Ortin, A, Prats, R, Aguilera, E, Marti, D, Fernandez, L, Ferrer, M, Lanziotti, V, Pulcheri, L, Ribeiro, M, Barbosa, A, E. Silva, J, Soares, M, Marqués, M, Moreno, A, Pizarraya, A, Smani, Y, Connell, M, Zhang, L, Parker, R, Banerjee, I, Clermont, G, Norberg, E, Oras, J, Cuisinier, A, Maufrais, C, Payen, J, Nottin, S, Walther, G, Arib, S, Bilotta, F, Badenes, R, Rubulotta, F, Mirek, S, Monfort, B, Stazi, E, Roig, A, Magnoni, S, Marando, M, Pifferi, S, Conte, V, Ortolano, F, Carbonara, M, Bertani, G, Scola, E, Cadioli, M, Triulzi, F, Colombo, A, Stocchetti, N, Rotzel, H, Lázaro, A, Prada, D, Guimillo, M, Piqueras, C, Guia, J, Simon, M, Arizmendi, A, Carratalá, A, El Maraghi, S, Yehia, A, Bakry, M, Shoman, A, Backes, F, Bianchin, M, Vieira, S, de Souza, A, Backes, A, Klein, C, Arunkumar, A, Lozano, A, Gallaher, C, Cattlin, S, Gordon, S, Picard, J, Fontana, V, Bond, O, Nobile, L, Mrozek, S, Delamarre, L, Capilla, F, Al Saati, T, Fourcade, O, Dominguez Berrot, A, Gonzalez Vaquero, M, Vallejo Pascual, M, Gupta, D, Ivory, B, Chopra, M, Mccarthy, J, Felderhof, C, Macneil, C, Maggiorini, M, Duska, F, Fumis, R, Junior, J, Amarante, G, Skorko, A, Sanders, S, Aron, J, Kroll, R, Redfearn, C, Krishnan, P, Khalil, J, Kongpolprom, N, Gulia, V, Lourenço, E, Duro, C, Baptista, G, Alves, A, Arminda, B, Rodrigues, M, Hayward, J, Baldwin, F, Gray, R, Katinakis, P, Stijf, M, Ten Kleij, M, Jansen Frederiks, M, Broek, R, de Bruijne, M, Spronk, P, Sinha, K, Luney, M, Palmer, K, Keating, L, Abu Habsa, M, Bahl, R, Baskaralingam, N, Ahmad, A, Kanapeckaite, L, Bhatti, P, Glace, S, Jeyabraba, S, Lewis, H, Kostopoulos, A, Raja, M, West, A, Ely, A, Turkoglu, L, Zolfaghari, P, Baptista, J, Marques, M, Martins, P, Pimentel, J, Su, Y, Villacres, S, Stone, M, Parsikia, A, Medar, S, O'Dea, K, Porter, J, Tirlapur, N, Jonathan, J, Singh, S, Takata, M, Mcwhirter, E, Lyon, R, Hariz, M, Azmi, E, Alkhan, J, Movsisyan, V, Petrikov, S, Marutyan, Z, Aliev, I, Evdokimov, A, Antonucci, E, Merz, T, Hartmann, C, Calzia, E, Radermacher, P, Nußbaum, B, Huber Lang, M, Gröger, M, Svoren Jabalera, E, Davenport, E, Humburg, P, Knight, J, Hinds, C, Jun, I, Kim, W, Besch, G, Perrotti, A, Puyraveau, M, Baltres, M, Samain, E, Chocron, S, Pili Floury, S, Plata Menchaca, E, Sabater Riera, J, Estruch, M, Boza, E, Toscana Fernández, J, Bruguera Pellicer, E, Ordoñez Llanos, J, Pérez Fernández, X, Cavaleiro, P, Tralhão, A, Arrigo, M, Lopes, J, Lebrun, M, Cholley, B, Perezvela, J, Marinmateos, H, Rivera, J, Llorente, M, De Marcos, B, Fernandez, F, Laborda, C, Zamora, D, Delgado, J, Imperiali, C, Dastis, M, Górka, J, Górka, K, Iwaniec, T, Frołow, M, Polok, K, Fronczek, J, Kózka, M, Musiał, J, Szczeklik, W, Sileli, M, Moursia, C, Maleoglou, H, Leleki, K, Uz, Z, Ince, Y, Papatella, R, Bulent, E, De Mol, B, Vicka, V, Gineityte, D, Ringaitiene, D, Norkiene, I, Sipylaite, J, Möller, C, Thomas Rueddel, D, Vlasakov, V, Rochwerg, B, Theurer, P, Al Sibai, J, Camblor, P, Fernandez, P, Gala, J, Guisasola, J, Tamura, T, Miyajima, I, Yamashita, K, Yokoyama, M, Dalampini, E, Nastou, M, Baddour, A, Ignatiadis, A, Asteri, T, Hathorn, K, Purtle, S, Viana, M, Tonietto, T, Gross, L, Costa, V, Tavares, A, Lisboa, B, Moraes, R, Viana, L, Azevedo, M, Ceniccola, G, Pequeno, R, Holanda, T, Mendonça, V, Araújo, W, Carvalho, L, Segaran, E, Vickers, L, Brinchmann, K, Wignall, I, De Brito Ashurst, I, Del Olmo, R, Vaquerizo, C, Carreño, R, Gálvez, V, Kaminsky, G, Nieto, B, Fuentes, M, De la Torre, M, Torres, E, Alonso, A, Velayos, C, Saldaña, T, Escribá, A, Grip, J, Kölegård, R, Sundblad, P, Rooyackers, O, Naser, B, Jaziri, F, Jazia, A, Barghouth, M, Hentati, O, Skouri, W, El Euch, M, Mahfoudhi, M, Turki, S, Abdelghni, K, Abdallah, B, Maha, B, Lorente, M, Włudarczyk, A, Hałek, A, Bargouth, M, Bennasr, M, Abdelghani, K, Abdallah, T, Geenen, I, Parienti, J, Shum, H, King, H, Yan, W, Londoño, J, Cardenas, C, Pedrosa, M, Gubianas, C, Bertolin, C, Batllori, N, Sirvent, J, Mukhopadhyay, A, Chan, H, Kowitlawakul, Y, Remani, D, Leong, C, Henry, C, Puthucheary, Z, Mendsaikhan, N, Begzjav, T, Lundeg, G, Dünser, M, Welsh, S, Guerra, E, Zerpa, M, Zechner, F, Berdaguer, F, Risso Vazquez, A, Masevicius, F, Greaney, D, Magee, A, Fitzpatrick, G, Lugo Cob, R, Tejeda Huezo, B, Cano Oviedo, A, Aydogan, M, Togal, T, Taha, A, Chai, H, Kam, C, Razali, S, Sivasamy, V, Kuan, L, Morales, M, Pires, T, Azevedo, L, Azevedo, L., GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, and CITERIO, GIUSEPPE
Published: 2016

23. Weda pool cleaner Concept P100

Author: Abukar, Hared, Al Saati, Firas, Abukar, Hared, and Al Saati, Firas
Abstract: Syftet med detta examensarbete var att ta fram en ny drivlina för Wedas nuvarande robot poolrengörare W50. I nuläget är pumpen integrerad i drivlinan som består endast av en motor som driver både hjul och pump. Detta orsakar ett kritiskt problem som påverkar städning vid lutningar i poolen då roboten glider ner för lutningen. För att få en bättre insikt i hur produkten fungerar gjordes studiebesök till Weda. Projektgruppendokumenterade och observerade hur den nuvarande modellen och dess komponenter är monterade. Intervjuer utfördes med vaktmästare och fastighetsskötare inom olika kommunala bad och hotellpooler för att få en djupare förståelse för hur dessa robot poolrengörare används och vilka förbättringsområden som finns. Faktainsamlingen användes som grund för att ta fram förslag för nya och alternativa komponenter till det nya konceptet. De olika lösningarna blev sedan utvärderade med hjälp en beslutsmatris för att kunna bestämma vilka komponenter som skulle ingå i det slutgiltiga konceptet. Arbetet har utförts i nära samarbete med Adigo Drives, som bistått med sin expertis gällande motorer och drivlinor. Resultatet utmynnade i ett slutgiltigt koncept med en ny drivlina och en lägre vikt än den befintliga roboten., The purpose of this study was to develop a new drivetrain for Wedas current robot pool cleaner W50. Currently, the pump is integrated in the drivetrain which contains only one motor running both wheels and pump. This causes a critical problem affecting cleaning when encountering inclinations in the pool, the robot slides down the slope. To get a better understanding of how the product works, the project group made study visits to Weda. The group documented and observed how the current model and its components are mounted. Interviews were conducted with caretakers and janitors at various municipal swimming pools and hotel pools to get a deeper understanding of how these robot pool cleaners are used and what areas for improvement that exists. The research was used as a foundation for suggestions of new and alternative components for the new concept. The different solutions were then evaluated using a decision matrix to determine which components should be included in the final concept. The work has been carried out in close cooperation with Adigo Drives, which assisted the group with their expertise regarding motors and powertrains. The results culminated in a final concept with a new powertrain and a lower weight than the existing robot.
Published: 2016

24. Weda pool cleaner Concept P100

Author: Abukar, Hared, Al Saati, Firas, Abukar, Hared, and Al Saati, Firas
Abstract: Syftet med detta examensarbete var att ta fram en ny drivlina för Wedas nuvarande robot poolrengörare W50. I nuläget är pumpen integrerad i drivlinan som består endast av en motor som driver både hjul och pump. Detta orsakar ett kritiskt problem som påverkar städning vid lutningar i poolen då roboten glider ner för lutningen. För att få en bättre insikt i hur produkten fungerar gjordes studiebesök till Weda. Projektgruppendokumenterade och observerade hur den nuvarande modellen och dess komponenter är monterade. Intervjuer utfördes med vaktmästare och fastighetsskötare inom olika kommunala bad och hotellpooler för att få en djupare förståelse för hur dessa robot poolrengörare används och vilka förbättringsområden som finns. Faktainsamlingen användes som grund för att ta fram förslag för nya och alternativa komponenter till det nya konceptet. De olika lösningarna blev sedan utvärderade med hjälp en beslutsmatris för att kunna bestämma vilka komponenter som skulle ingå i det slutgiltiga konceptet. Arbetet har utförts i nära samarbete med Adigo Drives, som bistått med sin expertis gällande motorer och drivlinor. Resultatet utmynnade i ett slutgiltigt koncept med en ny drivlina och en lägre vikt än den befintliga roboten., The purpose of this study was to develop a new drivetrain for Wedas current robot pool cleaner W50. Currently, the pump is integrated in the drivetrain which contains only one motor running both wheels and pump. This causes a critical problem affecting cleaning when encountering inclinations in the pool, the robot slides down the slope. To get a better understanding of how the product works, the project group made study visits to Weda. The group documented and observed how the current model and its components are mounted. Interviews were conducted with caretakers and janitors at various municipal swimming pools and hotel pools to get a deeper understanding of how these robot pool cleaners are used and what areas for improvement that exists. The research was used as a foundation for suggestions of new and alternative components for the new concept. The different solutions were then evaluated using a decision matrix to determine which components should be included in the final concept. The work has been carried out in close cooperation with Adigo Drives, which assisted the group with their expertise regarding motors and powertrains. The results culminated in a final concept with a new powertrain and a lower weight than the existing robot.
Published: 2016

25. Intracerebral hemorrhage in ICU: is it worth treating?

Author: Sivakumar, S, Taccone, F, Desai, K, Lazaridis, C, Skarzynski, M, Sekhon, M, Henderson, W, Griesdale, D, Chapple, L, Deane, A, Williams, L, Strickland, R, Lange, K, Heyland, D, Chapman, M, Rowland, M, Garry, P, Westbrook, J, Corkill, R, Antoniades, C, Pattinson, K, Fatania, G, Strong, A, Myers, R, Jermaine, C, Robertson, C, Rusin, C, Hofmeijer, J, Sondag, L, Tjepkema Cloostermans, M, Beishuizen, A, Bosch, F, van Putten, M, Carteron, L, Patet, C, Solari, D, Oddo, M, Ali, M, Dias, C, Almeida, R, Vaz Ferreira, A, Silva, J, Monteiro, E, Cerejo, A, Rocha, A, Elsayed, A, Abougabal, A, Beshey, B, Alzahaby, K, Pozzebon, S, Ortiz, A, Cristallini, S, Lheureux, O, Brasseur, A, Vincent, J, Creteur, J, Hravnak, M, Yousef, K, Chang, Y, Crago, E, Friedlander, R, Abdelmonem, S, Tahon, S, Helmy, T, Meligy, H, Puig, F, Dunn Siegrist, I, Pugin, J, Gupta, S, Govil, D, Srinivasan, S, Patel, S, N, J, Gupta, A, Tomar, D, Shafi, M, Harne, R, Arora, D, Talwar, N, Mazumdar, S, Papakrivou, E, Makris, D, Manoulakas, E, Tsolaki, B, Karadodas, B, Zakynthinos, E, Garcia, I, Martin, A, Encinares, V, Ibañez, M, Montero, J, Labrador, G, Cangueiro, T, Poulose, V, Koh, J, Kam, J, Yeter, H, Kara, A, Aktepe, O, Topeli, A, Tsolakoglou, I, Intas, G, Stergiannis, P, Kolaros, A, Chalari, E, Athanasiadou, E, Martika, A, Fildisis, G, Faivre, V, Mengelle, C, Favier, B, Payen, D, Poppe, A, Winkler, M, Mudersbach, E, Schreiber, J, Wruck, M, Schwedhelm, E, Kluge, S, Zöllner, C, Tavladaki, T, Spanaki, A, Dimitriou, H, Kondili, E, Choulaki, C, Meleti, E, Kafetzopoulos, D, Georgopoulos, D, Briassoulis, G, la Torre, A, de la Torre Prados, M, Tsvetanova Spasova, T, Nuevo Ortega, P, Rueda Molina, C, Fernández Porcel, A, Camara Sola, E, Salido Díaz, L, García Alcántara, A, Meleti, D, Suberviola, B, Riera, J, Rellan, L, Sanchez, M, Robles, J, Lopez, E, Vicente, R, Miñambres, E, Santibañez, M, Le Guen, M, Moore, J, Mason, N, Windpassinger, M, Plattner, O, Mascha, E, Sessler, D, Research, O, Melia, U, Fontanet, J, van den Berg, J, Struys, M, Vereecke, H, Jensen, E, Rood, P, van de Schoor, F, van Tertholen, K, Pickkers, P, van den Boogaard, M, Beardow, Z, Redhead, H, Paramasivam, K, Numan, T, Kamper, A, Peelen, L, Zeman, P, Slooter, A, van Ewijk, C, Jacobs, G, Girbes, A, Myatra, S, Harish, M, Prabu, N, Siddiqui, S, Kulkarni, A, Divatia, J, Murbach, L, Leite, M, Osaku, E, Costa, C, Pelenz, M, Neitzke, N, Moraes, M, Jaskowiak, J, Silva, M, Zaponi, R, Abentroth, L, Ogasawara, S, Jorge, A, Duarte, P, Hernández Sánchez, N, Sánchez Hurtado, L, García Guillen, F, Ñamendys Silva, S, Maghsoudi, B, Emami, M, Khosravi, M, Zand, F, Tabatabaie, H, Masjedi, M, Sabetiyan, G, Mokri, A, Troubleyn, J, Diltoer, M, Jacobs, R, Nguyen, D, De Waele, E, De Regt, J, Honoré, P, Van Gorp, V, Spapen, H, Contreras, R, Toapanta, N, Moreno, G, Sabater, J, Torrado, H, Gonzalez, M, Marin, M, Farigola, E, Gonzalez, A, Fernandez, J, Vera, A, Gisbert, X, Juliá, C, Uya, J, Corral, L, Elias Jones, I, Gemmell, L, Mackay, A, Randall, D, Adwaney, A, Blunden, M, Prowle, J, Kirwan, C, Thomas, N, Owen, H, Darwin, L, Conway, D, Atkinson, D, Sharman, M, Barbanti, C, Amour, J, Gaudard, P, Rozec, B, Mauriat, P, M'Rini, M, Leger, P, Cambonie, G, Liet, J, Girard, C, Laroche, S, Damas, P, Assaf, Z, Loron, G, Lecourt, L, Pouard, P, Kim, S, Na, S, Kim, J, Oh, S, Jung, C, Yoo, S, Min, S, Chung, E, Lee, H, Lee, N, Lee, K, Suh, K, Ryu, H, Marshall, D, Goodson, R, Salciccioli, J, Shalhoub, J, Potter, E, Kirk Bayley, J, Karanjia, N, Forni, L, Creagh Brown, B, Bossy, M, Nyman, M, Tailor, A, D'Antini, D, Spadaro, S, Valentino, F, Sollitto, F, Cinnella, G, Mirabella, L, Calvo, F, Bejarano, N, Padilla, D, Baladron, V, Villajero, P, Villazala, R, Redondo, J, Yuste, A, Liu, J, Shen, F, Teboul, J, Anguel, N, Beurton, A, Bezaz, N, Richard, C, Monnet, X, Fossali, T, Colombo, R, Ottolina, D, Rossetti, M, Mazzucco, C, Marchi, A, Porta, A, Catena, E, Tollisen, K, Andersen, G, Heyerdahl, F, Jacobsen, D, de Waard, M, van 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Albrecht, M, González, L, Alonso, D, Sánchez, R, Lucas, J, Ferlitsch, A, Fauler, G, Trauner, M, Pischke, S, Fischer, L, Thaiss, F, Koch, M, Bangert, K, Lohse, A, Nashan, B, Sterneck, M, Faenza, S, Siniscalchi, A, Pierucci, E, Mancini, E, Ricci, D, Gemelli, C, Cuoghi, A, Magnani, S, Atti, M, Sotos, F, Cánovas, J, López, A, Burruezo, A, Torres, D, Herrera Gutierrez, M, Barrueco Francioni, J, Arias Verdú, D, Lozano Saez, R, Quesada Garcia, G, Seller Pérez, G, Figueiredo, A, Anzola, Y, Pereira, R, Bento, L, Lai, M, Deiana, M, Seller Perez, G, Vardas, K, Ilia, S, Sertedaki, A, Charmadari, E, Stratakis, C, Briassouli, E, Goukos, D, Psarra, K, Botoula, E, Tsagarakis, S, Mageira, E, Routsi, C, Nanas, S, Campello, E, Radu, C, Su, H, Lam, Y, Willis, K, Pullar, V, Hubner, R, Tsang, J, de Guadiana Romualdo, L, Rebollo Acebes, S, Esteban Torrella, P, Jiménez Sánchez, R, Jiménez Santos, E, Ortín Freire, A, Hernando Holgado, A, Albaladejo Otón, M, Coelho, L, Rabello, L, Póvoa, P, Varis, E, Poukkanen, M, Jacob, S, Takala, J, Wilkman, E, Lundberg, O, Bergenzaun, L, Rydén, J, Rosenqvist, M, Melander, O, Chew, M, Kishihara, Y, Yasuda, H, Jimenez, R, Torrella, P, Fernandez, A, Sanchez, S, Ortin, A, Prats, R, Aguilera, E, Marti, D, Fernandez, L, Ferrer, M, Lanziotti, V, Pulcheri, L, Ribeiro, M, Barbosa, A, E. Silva, J, Soares, M, Marqués, M, Moreno, A, Pizarraya, A, Smani, Y, Connell, M, Zhang, L, Parker, R, Banerjee, I, Clermont, G, Norberg, E, Oras, J, Cuisinier, A, Maufrais, C, Payen, J, Nottin, S, Walther, G, Arib, S, Bilotta, F, Badenes, R, Rubulotta, F, Mirek, S, Monfort, B, Stazi, E, Roig, A, Magnoni, S, Marando, M, Pifferi, S, Conte, V, Ortolano, F, Carbonara, M, Bertani, G, Scola, E, Cadioli, M, Triulzi, F, Colombo, A, Stocchetti, N, Rotzel, H, Lázaro, A, Prada, D, Guimillo, M, Piqueras, C, Guia, J, Simon, M, Arizmendi, A, Carratalá, A, El Maraghi, S, Yehia, A, Bakry, M, Shoman, A, Backes, F, Bianchin, M, Vieira, S, de Souza, A, Backes, A, Klein, C, Arunkumar, A, Lozano, A, Gallaher, C, Cattlin, S, Gordon, S, Picard, J, Fontana, V, Bond, O, Nobile, L, Mrozek, S, Delamarre, L, Capilla, F, Al Saati, T, Fourcade, O, Dominguez Berrot, A, Gonzalez Vaquero, M, Vallejo Pascual, M, Gupta, D, Ivory, B, Chopra, M, Mccarthy, J, Felderhof, C, Macneil, C, Maggiorini, M, Duska, F, Fumis, R, Junior, J, Amarante, G, Skorko, A, Sanders, S, Aron, J, Kroll, R, Redfearn, C, Krishnan, P, Khalil, J, Kongpolprom, N, Gulia, V, Lourenço, E, Duro, C, Baptista, G, Alves, A, Arminda, B, Rodrigues, M, Hayward, J, Baldwin, F, Gray, R, Katinakis, P, Stijf, M, Ten Kleij, M, Jansen Frederiks, M, Broek, R, de Bruijne, M, Spronk, P, Sinha, K, Luney, M, Palmer, K, Keating, L, Abu Habsa, M, Bahl, R, Baskaralingam, N, Ahmad, A, Kanapeckaite, L, Bhatti, P, Glace, S, Jeyabraba, S, Lewis, H, Kostopoulos, A, Raja, M, West, A, Ely, A, Turkoglu, L, Zolfaghari, P, Baptista, J, Marques, M, Martins, P, Pimentel, J, Su, Y, Villacres, S, Stone, M, Parsikia, A, Medar, S, O'Dea, K, Porter, J, Tirlapur, N, Jonathan, J, Singh, S, Takata, M, Mcwhirter, E, Lyon, R, Hariz, M, Azmi, E, Alkhan, J, Movsisyan, V, Petrikov, S, Marutyan, Z, Aliev, I, Evdokimov, A, Antonucci, E, Merz, T, Hartmann, C, Calzia, E, Radermacher, P, Nußbaum, B, Huber Lang, M, Gröger, M, Svoren Jabalera, E, Davenport, E, Humburg, P, Knight, J, Hinds, C, Jun, I, Kim, W, Besch, G, Perrotti, A, Puyraveau, M, Baltres, M, Samain, E, Chocron, S, Pili Floury, S, Plata Menchaca, E, Sabater Riera, J, Estruch, M, Boza, E, Toscana Fernández, J, Bruguera Pellicer, E, Ordoñez Llanos, J, Pérez Fernández, X, Cavaleiro, P, Tralhão, A, Arrigo, M, Lopes, J, Lebrun, M, Cholley, B, Perezvela, J, Marinmateos, H, Rivera, J, Llorente, M, De Marcos, B, Fernandez, F, Laborda, C, Zamora, D, Delgado, J, Imperiali, C, Dastis, M, Górka, J, Górka, K, Iwaniec, T, Frołow, M, Polok, K, Fronczek, J, Kózka, M, Musiał, J, Szczeklik, W, Sileli, M, Moursia, C, Maleoglou, H, Leleki, K, Uz, Z, Ince, Y, Papatella, R, Bulent, E, De Mol, B, Vicka, V, Gineityte, D, Ringaitiene, D, Norkiene, I, Sipylaite, J, Möller, C, Thomas Rueddel, D, Vlasakov, V, Rochwerg, B, Theurer, P, Al Sibai, J, Camblor, P, Fernandez, P, Gala, J, Guisasola, J, Tamura, T, Miyajima, I, Yamashita, K, Yokoyama, M, Dalampini, E, Nastou, M, Baddour, A, Ignatiadis, A, Asteri, T, Hathorn, K, Purtle, S, Viana, M, Tonietto, T, Gross, L, Costa, V, Tavares, A, Lisboa, B, Moraes, R, Viana, L, Azevedo, M, Ceniccola, G, Pequeno, R, Holanda, T, Mendonça, V, Araújo, W, Carvalho, L, Segaran, E, Vickers, L, Brinchmann, K, Wignall, I, De Brito Ashurst, I, Del Olmo, R, Vaquerizo, C, Carreño, R, Gálvez, V, Kaminsky, G, Nieto, B, Fuentes, M, De la Torre, M, Torres, E, Alonso, A, Velayos, C, Saldaña, T, Escribá, A, Grip, J, Kölegård, R, Sundblad, P, Rooyackers, O, Naser, B, Jaziri, F, Jazia, A, Barghouth, M, Hentati, O, Skouri, W, El Euch, M, Mahfoudhi, M, Turki, S, Abdelghni, K, Abdallah, B, Maha, B, Lorente, M, Włudarczyk, A, Hałek, A, Bargouth, M, Bennasr, M, Abdelghani, K, Abdallah, T, Geenen, I, Parienti, J, Shum, H, King, H, Yan, W, Londoño, J, Cardenas, C, Pedrosa, M, Gubianas, C, Bertolin, C, Batllori, N, Sirvent, J, Mukhopadhyay, A, Chan, H, Kowitlawakul, Y, Remani, D, Leong, C, Henry, C, Puthucheary, Z, Mendsaikhan, N, Begzjav, T, Lundeg, G, Dünser, M, Welsh, S, Guerra, E, Zerpa, M, Zechner, F, Berdaguer, F, Risso Vazquez, A, Masevicius, F, Greaney, D, Magee, A, Fitzpatrick, G, Lugo Cob, R, Tejeda Huezo, B, Cano Oviedo, A, Aydogan, M, Togal, T, Taha, A, Chai, H, Kam, C, Razali, S, Sivasamy, V, Kuan, L, Morales, M, Pires, T, Azevedo, L, Azevedo, L., GIUSSANI, CARLO GIORGIO, SGANZERLA, ERIK PIETRO, and CITERIO, GIUSEPPE
Published: 2016

26. Requirement Tracing using Term Extraction

Author: Al-Saati, Najla, Abdul-Jaleel, Raghda, Al-Saati, Najla, and Abdul-Jaleel, Raghda
Abstract: Requirements traceability is an essential step in ensuring the quality of software during the early stages of its development life cycle. Requirements tracing usually consists of document parsing, candidate link generation and evaluation and traceability analysis. This paper demonstrates the applicability of Statistical Term Extraction metrics to generate candidate links. It is applied and validated using two data sets and four types of filters two for each data set, 0.2 and 0.25 for MODIS, 0 and 0.05 for CM1. This method generates requirements traceability matrices between textual requirements artifacts (such as high-level requirements traced to low-level requirements). The proposed method includes ten word frequency metrics divided into three main groups for calculating the frequency of terms. The results show that the proposed method gives better result when compared with the traditional TF-IDF method.
Published: 2015

27. Ergonomisk Analys av Penclic Mouse medförbättringsförslag

Author: AL SAATI, FIRAS, ERIKSSON, MAX, AL SAATI, FIRAS, and ERIKSSON, MAX
Published: 2013

28. Ergonomisk Analys av Penclic Mouse medförbättringsförslag

Author: AL SAATI, FIRAS, ERIKSSON, MAX, AL SAATI, FIRAS, and ERIKSSON, MAX
Published: 2013

29. The Use of Cuckoo Search in Estimating the Parameters of Software Reliability Growth Models

Author: AL-Saati, Dr. Najla Akram, Abd-AlKareem, Marwa, AL-Saati, Dr. Najla Akram, and Abd-AlKareem, Marwa
Abstract: This work aims to investigate the reliability of software products as an important attribute of computer programs; it helps to decide the degree of trustworthiness a program has in accomplishing its specific functions. This is done using the Software Reliability Growth Models (SRGMs) through the estimation of their parameters. The parameters are estimated in this work based on the available failure data and with the search techniques of Swarm Intelligence, namely, the Cuckoo Search (CS) due to its efficiency, effectiveness and robustness. A number of SRGMs is studied, and the results are compared to Particle Swarm Optimization (PSO), Ant Colony Optimization (ACO) and extended ACO. Results show that CS outperformed both PSO and ACO in finding better parameters tested using identical datasets. It was sometimes outperformed by the extended ACO. Also in this work, the percentages of training data to testing data are investigated to show their impact on the results.
Published: 2013

30. Föräldraskap och ADHD : En kvalitativ studie om förhållningssätt till att vara förälder med ADHD, samt till föreställningar om ADHD och föräldraskap.

Author: Al Saati Edsman, Hannah and Al Saati Edsman, Hannah
Abstract: ADHD är en diagnos som länge givits till barn. Därför rör forskning om ADHD mestadels barn och unga. Viss klinisk forskning finns om föräldrar med ADHD, denna har fokuserat på deras barns framtida utveckling. Kunskap om hur det kan upplevas att vara förälder och ha en ADHD-diagnos saknas. Denna kvalitativa intervjustudie har undersökt olika sätt som föräldrar med ADHD kan förhålla sig till föreställningar kring föräldraskap och ADHD. Den har även haft som syfte att ge förståelse för några olika sätt som personer som är föräldrar och har en ADHD-diagnos kan se på sig själva och sitt föräldraskap. Studien bygger på tre halvstrukturerade intervjuer med föräldrar som har, eller utreds för, en ADHD-diagnos. I studiens teoretiska referensram ses både funktionsförmåga och föräldraskap som något som påverkas av sociala normer och maktordningar. Kön och ålder framkom i analysen som starkt strukturerande ordningar i diskurser gällande både ADHD och föräldraskap. Intervjupersonerna gav uttryck för att en ADHD-diagnos kan innebära både svårigheter och tillgångar i föräldraskapet. Svårigheterna kan bland annat utgöras av stresskänslighet och brist på struktur. Bland tillgångarna kan nämnas hög aktivitetsnivå och barnasinnet i behåll. Av studiens resultat framkommer också att vissa föräldrar med ADHD kan se föräldraskapet som en tillgång och resurs. Studien gör inte anspråk på att uttala sig om skillnader mellan föräldrar med och utan ADHD. Samma goda och mindre goda erfarenheter och egenskaper kan finnas hos många föräldrar både med och utan ADHD, däremot förklarade intervjupersonerna i intervjusituationerna vissa styrkor och svagheter utifrån sin ADHD-diagnos.
Published: 2012

31. Föräldraskap och ADHD : En kvalitativ studie om förhållningssätt till att vara förälder med ADHD, samt till föreställningar om ADHD och föräldraskap.

Author: Al Saati Edsman, Hannah and Al Saati Edsman, Hannah
Abstract: ADHD är en diagnos som länge givits till barn. Därför rör forskning om ADHD mestadels barn och unga. Viss klinisk forskning finns om föräldrar med ADHD, denna har fokuserat på deras barns framtida utveckling. Kunskap om hur det kan upplevas att vara förälder och ha en ADHD-diagnos saknas. Denna kvalitativa intervjustudie har undersökt olika sätt som föräldrar med ADHD kan förhålla sig till föreställningar kring föräldraskap och ADHD. Den har även haft som syfte att ge förståelse för några olika sätt som personer som är föräldrar och har en ADHD-diagnos kan se på sig själva och sitt föräldraskap. Studien bygger på tre halvstrukturerade intervjuer med föräldrar som har, eller utreds för, en ADHD-diagnos. I studiens teoretiska referensram ses både funktionsförmåga och föräldraskap som något som påverkas av sociala normer och maktordningar. Kön och ålder framkom i analysen som starkt strukturerande ordningar i diskurser gällande både ADHD och föräldraskap. Intervjupersonerna gav uttryck för att en ADHD-diagnos kan innebära både svårigheter och tillgångar i föräldraskapet. Svårigheterna kan bland annat utgöras av stresskänslighet och brist på struktur. Bland tillgångarna kan nämnas hög aktivitetsnivå och barnasinnet i behåll. Av studiens resultat framkommer också att vissa föräldrar med ADHD kan se föräldraskapet som en tillgång och resurs. Studien gör inte anspråk på att uttala sig om skillnader mellan föräldrar med och utan ADHD. Samma goda och mindre goda erfarenheter och egenskaper kan finnas hos många föräldrar både med och utan ADHD, däremot förklarade intervjupersonerna i intervjusituationerna vissa styrkor och svagheter utifrån sin ADHD-diagnos.
Published: 2012

32. Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study

Author: Laurent, C, Müller, S, Do, C, Al Saati, T, Allart, S, Larocca, Luigi Maria, Hohaus, Stefan, Duchez, S, Quillet Mary, A, Laurent, G, Brousset, P, Valitutti, S., Larocca, Luigi Maria (ORCID:0000-0003-1739-4758), Hohaus, Stefan (ORCID:0000-0002-5534-7197), Laurent, C, Müller, S, Do, C, Al Saati, T, Allart, S, Larocca, Luigi Maria, Hohaus, Stefan, Duchez, S, Quillet Mary, A, Laurent, G, Brousset, P, Valitutti, S., Larocca, Luigi Maria (ORCID:0000-0003-1739-4758), and Hohaus, Stefan (ORCID:0000-0002-5534-7197)
Abstract: CD8+ CTLs are thought to play a role in the control of follicular lymphoma (FL). Yet, the link between CTL tissue distribution, activation status, ability to kill FL cells in vivo, and disease progression is still elusive. Pretreatment lymph nodes from FL patients were analyzed by IHC (n = 80) or by 3-color confocal microscopy (n = 10). IHC revealed a rich infiltrate of CD8+ granzyme B+ (GrzB) cells in FL interfollicular spaces. Accordingly, confocal microscopy showed an increased number of CD3+CD8+GrzB+ CTLs and a brighter GrzB staining in individual CTL in FL samples compared with reactive lymph nodes. CTLs did not penetrate tumor nodules. In 3-dimensional (3-D) image reconstructions, CTLs were detected at the FL follicle border where they formed lytic synapse-like structures with FL B cells and with apoptotic cells, suggesting an in situ cytotoxic function. Finally, although GrzB expression in CTLs did not correlate with risk factors, high GrzB content correlated with prolonged progression free-survival (PFS) after rituximab-combined chemotherapy. Our results show the recruitment of armed CTLs with a tumor-controlling potential into FL lymph nodes and suggest that CTL-associated GrzB expression could influence PFS in FL patients having received rituximab-combined chemotherapy.
Published: 2011

33. Assassin's Creed : A Multi-Cultural Read

Author: Seif El-Nasr, Magy, Al-Saati, Maha, Niedenthal, Simon, Milam, David, Seif El-Nasr, Magy, Al-Saati, Maha, Niedenthal, Simon, and Milam, David
Abstract: Video game playing is becoming a predominant part of popular culture. Games, like Assassin’s Creed (Ubisoft, released 2007), The Sims (Maxis, released 2000), Guitar Hero (RedOctane, released 2005), and World of War Craft (Bilizzard, released 2004), have attracted players from many different cultures and age groups. In this paper, we propose that the experience of playing a video game, like Assassin’s Creed, is a personal experience shaped through one’s emotional values, expectations, knowledge, and attitudes as influenced by culture. As we set out to review the Assassin’s Creed game, we discovered that each one of us had a different experience with the game. In this paper, we draw on our Assassin’s Creed play sessions. This experience is shaped by our different cultural viewpoints, including Middle-Eastern and Western, as well as intellectual disciplinary backgrounds, which include architecture, theatre, and computer science. To Maha and Magy, for example, the game aroused many nostalgic feelings through its simulated Middle-Eastern cities, the use of Arabic words, accents and gestures, and the detailed Middle-Eastern architectural design. While such small details meant much when viewed by Maha and Magy, their values were different when viewed by Simon and David. To both Simon and David, the game play experience was heightened through the beautiful architectural detail and the use of the environment layout as a function of gameplay, such as the use of rooftops for platforming, fast movement and flying-like actions, and stealth. This collaborative game review suggests that a game is, in interesting ways, experienced and perceived differently by players from divergent cultural-linguistic situations.
Published: 2008

34. Assassin's Creed : A Multi-Cultural Read

Author: Seif El-Nasr, Magy, Al-Saati, Maha, Niedenthal, Simon, Milam, David, Seif El-Nasr, Magy, Al-Saati, Maha, Niedenthal, Simon, and Milam, David
Abstract: Video game playing is becoming a predominant part of popular culture. Games, like Assassin’s Creed (Ubisoft, released 2007), The Sims (Maxis, released 2000), Guitar Hero (RedOctane, released 2005), and World of War Craft (Bilizzard, released 2004), have attracted players from many different cultures and age groups. In this paper, we propose that the experience of playing a video game, like Assassin’s Creed, is a personal experience shaped through one’s emotional values, expectations, knowledge, and attitudes as influenced by culture. As we set out to review the Assassin’s Creed game, we discovered that each one of us had a different experience with the game. In this paper, we draw on our Assassin’s Creed play sessions. This experience is shaped by our different cultural viewpoints, including Middle-Eastern and Western, as well as intellectual disciplinary backgrounds, which include architecture, theatre, and computer science. To Maha and Magy, for example, the game aroused many nostalgic feelings through its simulated Middle-Eastern cities, the use of Arabic words, accents and gestures, and the detailed Middle-Eastern architectural design. While such small details meant much when viewed by Maha and Magy, their values were different when viewed by Simon and David. To both Simon and David, the game play experience was heightened through the beautiful architectural detail and the use of the environment layout as a function of gameplay, such as the use of rooftops for platforming, fast movement and flying-like actions, and stealth. This collaborative game review suggests that a game is, in interesting ways, experienced and perceived differently by players from divergent cultural-linguistic situations.
Published: 2008

35. LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

Author: Bitoun, Emmanuelle, Micheloni, Alessia, Lamant, Laurence, Bonnart, Chrystelle, Tartaglia-Polcini, Alessandro, Cobbold, Christian, Al Saati, Talal, Mariotti, Feliciana, Mazereeuw-Hautier, Juliette, Boralevi, Franck, Hohl, Daniel, Harper, John, Bodemer, Christine, D'Alessio, Marina, Hovnanian, Alain, Bitoun, Emmanuelle, Micheloni, Alessia, Lamant, Laurence, Bonnart, Chrystelle, Tartaglia-Polcini, Alessandro, Cobbold, Christian, Al Saati, Talal, Mariotti, Feliciana, Mazereeuw-Hautier, Juliette, Boralevi, Franck, Hohl, Daniel, Harper, John, Bodemer, Christine, D'Alessio, Marina, and Hovnanian, Alain
Abstract: SPINK5, encoding the putative multi-domain serine protease inhibitor LEKTI, was recently identified as the defective gene in the severe autosomal recessive ichthyosiform skin condition, Netherton syndrome (NS). Using monoclonal and polyclonal antibodies, we show that LEKTI is a marker of epithelial differentiation, strongly expressed in the granular and uppermost spinous layers of the epidermis, and in differentiated layers of stratified epithelia. LEKTI expression was also demonstrated in normal differentiated human primary keratinocytes (HK) through detection of a 145 kDa full-length protein and a shorter isoform of 125 kDa. Both proteins are N-glycosylated and rapidly processed in a post-endoplasmic reticulum compartment into at least three C-terminal fragments of 42, 65 and 68 kDa, also identified in conditioned media. Processing of the 145 and 125 kDa precursors was prevented in HK by treatment with a furin inhibitor. In addition, in vitro cleavage of the recombinant 145 kDa precursor by furin generated C-terminal fragments of 65 and 68 kDa, further supporting the involvement of furin in LEKTI processing. In contrast, LEKTI precursors and proteolytic fragments were not detected in differentiated HK from NS patients. Defective expression of LEKTI in skin sections was a constant feature in NS patients, whilst an extended reactivity pattern was observed in samples from other keratinizing disorders, demonstrating that loss of LEKTI expression in the epidermis is a diagnostic feature of NS. The identification of novel processed forms of LEKTI provides the basis for future functional and structural studies of fragments with physiological relevance

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35 results on '"Al Saati A"'

1. Stump Appendicitis: A Complication of Post Appendectomy

2. The Brescia Internationally Validated European Guidelines on Minimally Invasive Pancreatic Surgery (EGUMIPS)

3. Standardizing definitions and terminology of left-sided pancreatic resections through an international Delphi consensus

4. Magnetosphere-Ionosphere-Thermosphere Coupling Study at Jupiter Based on Juno's First 30 Orbits and Modeling Tools

5. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.

6. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.

7. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype

8. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.

9. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype.

10. Single-cell atlas of developing murine adrenal gland reveals relation of Schwann cell precursor signature to neuroblastoma phenotype

11. Venous thromboembolism prevention protocol for adapting prophylaxis recommendations to the potential risk post total knee replacement: a randomized controlled trial

12. A Comparative Study on Parameter Estimation in Software Reliability Modeling using Swarm Intelligence

13. Applying Gene Expression Programming for Solving One-Dimensional Bin-Packing Problems

14. Selecting Best Software Reliability Growth Models: A Social Spider Algorithm based Approach

15. Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages.

16. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis : Fundamentals Of Care for UveitiS (FOCUS) Initiative

17. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis : Fundamentals Of Care for UveitiS (FOCUS) Initiative

18. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis : Fundamentals Of Care for UveitiS (FOCUS) Initiative

19. Guidance on Noncorticosteroid Systemic Immunomodulatory Therapy in Noninfectious Uveitis: Fundamentals Of Care for UveitiS (FOCUS) Initiative

20. Using Multi Expression Programming in Software Effort Estimation

21. Laparoscopic radical 'no-touch' left pancreatosplenectomy for pancreatic ductal adenocarcinoma : technique and results.

22. Intracerebral hemorrhage in ICU: is it worth treating?

23. Weda pool cleaner Concept P100

24. Weda pool cleaner Concept P100

25. Intracerebral hemorrhage in ICU: is it worth treating?

26. Requirement Tracing using Term Extraction

27. Ergonomisk Analys av Penclic Mouse medförbättringsförslag

28. Ergonomisk Analys av Penclic Mouse medförbättringsförslag

29. The Use of Cuckoo Search in Estimating the Parameters of Software Reliability Growth Models

30. Föräldraskap och ADHD : En kvalitativ studie om förhållningssätt till att vara förälder med ADHD, samt till föreställningar om ADHD och föräldraskap.

31. Föräldraskap och ADHD : En kvalitativ studie om förhållningssätt till att vara förälder med ADHD, samt till föreställningar om ADHD och föräldraskap.

32. Distribution, function, and prognostic value of cytotoxic T lymphocytes in follicular lymphoma: a 3-D tissue-imaging study

33. Assassin's Creed : A Multi-Cultural Read

34. Assassin's Creed : A Multi-Cultural Read

35. LEKTI proteolytic processing in human primary keratinocytes, tissue distribution and defective expression in Netherton syndrome

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35 results on '"Al Saati A"'

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