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The different solvent extract of Cajanus scarabaeoides (Family: Fabaceae) was studied for its antidiarrhoeal properties in experimental diarrhoea, induced by castor oil and magnesium sulphate in rat. At the doses of 500 mg/kg per oral, the methanol extract showed significant antidiarrhoeal activity in castor oil model and magnesium sulphate-induced diarrhea. Where as the petroleum ether extract and chloroform extract did not show any such activity. The methanol extract also significantly, reduced the intestinal transit in charcoal meal test when compared to atropine sulphate (5 mg/kg; i.m.). The results showed that the methanolic extract of Cajanus scarabaeoides have a significant antidiarrhoeal activity and supports its traditional uses in herbal medicine.

Objective: To investigate if the methanolic extract of Guiera senegalensis leaves actually possesses any anti-diarrhoeal and anti-inflammatory effects in rodents. Methods: The anti-diarrhoeal effect of extract (250 -750 mg/kg; p.o.), on intestinal propulsion in unanaesthetized rats was tested using charcoal meal method, castor oil-induced diarrhoea and fluid accumulation respectively. Its anti-inflammatory property was also investigated in carrageenin - induced rat hindpaw edema, acetic acid-induced writhing in mice as well as indomethacin-induced gastric ulceration in rats. The extract effects were compared with standard drugs (atropine, 1.0 mg/kg; yohimbine, 1.0 mg/kg; diphenoxylate, 5.0 mg/kg and cimetidine, 100.0 mg/kg respectively). Results: The extract (250 -750 mg/ kg) dose-dependently, reduced significantly (p< 0.01 - 0.001) the intestinal propulsive movement, castor oil-induced diarrhoea and intestinal fluid accumulation. Similarly, it also reduced indomethacin-induced ulceration, carrageenin-induced inflammation and acetic acid- induced writhing in mice. These effects were statistically significant. Conclusion: The results indicate that the observed anti-diarrhoeal and anti- inflammatory effects might in part be due to α2 - adrenoceptor stimulation, possession of anticholinergic properties, inhibition of prostaglandin synthesis as well as improvement of microcirculation.

Objective: To evaluate the different extracts of Psidium guajava bark for its antidiarrhoeal potential against several experimental models of diarrhoea in rats. Materials and methods: Antidiarrhoeal activity of methanolic and aqueous extracts of Psidium guajava bark was studied at dose of 50 mg/kg and 100 mg/kg body weight against gastrointestinal motility, castor oil-induced diarrhoea and prostaglandin E2-inducead enteropooling (PGE2) in rats. Results: The methanolic and aqueous extracts of P. guajava bark showed significant antidiarrhoeal activity in a dose dependent manner against all the experimental diarrhoea models. The potent antidiarrhoeal activity may be attributed to the presence of tannin and quercetin. Conclusion: The results indicated that both the extracts of P. guajava bark at dose of 100 mg/kg were found to be more potent than the reference standard drugs, loperamid and atropine.