Search

Your search keyword '"Blom J"' showing total 204 results
Start Over Author "Blom J" Database OAIster
204 results on '"Blom J"'

2. NFDI4Microbiota – national research data infrastructure for microbiota research

Author

Förstner, K.U., Becker, A., Blom, J., Bork, P., Clavel, T., Dieckmann, M., Goesmann, A., Götz, B., Gübitz, T., Hufsky, F., Jünemann, S., Körner, M.-L., Marz, M., Nunes da Rocha, Ulisses, Overmann, J., Pühler, A., Rebholz-Schuhmann, D., Sczyrba, A., Stoye, J., Vandendorpe, J., Van Rossum, T., McHardy, A., Förstner, K.U., Becker, A., Blom, J., Bork, P., Clavel, T., Dieckmann, M., Goesmann, A., Götz, B., Gübitz, T., Hufsky, F., Jünemann, S., Körner, M.-L., Marz, M., Nunes da Rocha, Ulisses, Overmann, J., Pühler, A., Rebholz-Schuhmann, D., Sczyrba, A., Stoye, J., Vandendorpe, J., Van Rossum, T., and McHardy, A.

Abstract

Microbes – bacteria, archaea, unicellular eukaryotes, and viruses – play an important role in human and environmental health. Growing awareness of this fact has led to a huge increase in microbiological research and applications in a variety of fields. Driven by technological advances that allow high-throughput molecular characterization of microbial species and communities, microbiological research now offers unparalleled opportunities to address current and emerging needs. As well as helping to address global health threats such as antimicrobial resistance and viral pandemics, it also has a key role to play in areas such as agriculture, waste management, water treatment, ecosystems remediation, and the diagnosis, treatment and prevention of various diseases. Reflecting this broad potential, billions of euros have been invested in microbiota research programs worldwide. Though run independently, many of these projects are closely related. However, Germany currently has no infrastructure to connect such projects or even compare their results. Thus, the potential synergy of data and expertise is being squandered. The goal of the NFDI4Microbiota consortium is to serve and connect this broad and heterogeneous research community by elevating the availability and quality of research results through dedicated training, and by facilitating the generation, management, interpretation, sharing, and reuse of microbial data. In doing so, we will also foster interdisciplinary interactions between researchers. NFDI4Microbiota will achieve this by creating a German microbial research network through training and community-building activities, and by creating a cloud-based system that will make the storage, integration and analysis of microbial data, especially omics data, consistent, reproducible, and accessible across all areas of life sciences. In addition to increasing the quality of microbial research in Germany, our training program will support widespread and proper usage of

Published
2023

3. Towards optimal use of antithrombotic therapy of people with cancer at the end of life:A research protocol for the development and implementation of the SERENITY shared decision support tool

Author

Goedegebuur, J., Abbel, D., Accassat, S., Achterberg, W. P., Akbari, A., Arfuch, V. M., Baddeley, E., Bax, J. J., Becker, D., Bergmeijer, B., Bertoletti, L., Blom, J. W., Calvetti, A., Cannegieter, S. C., Castro, L., Chavannes, N. H., Coma-Auli, N., Couffignal, C., Edwards, A., Edwards, M., Enggaard, H., Font, C., Gava, A., Geersing, G. J., Geijteman, E. C.T., Greenley, S., Gregory, C., Gussekloo, J., Hoffmann, I., Højen, A. A., van den Hout, W. B., Huisman, M. V., Jacobsen, S., Jagosh, J., Johnson, M. J., Jørgensen, L., Juffermans, C. C.M., Kempers, E. K., Konstantinides, S., Kroder, A. F., Kruip, M. J.H.A., Lafaie, L., Langendoen, J. W., Larsen, T. B., Lifford, K., van der Linden, Y. M., Mahé, I., Maiorana, L., Maraveyas, A., Martens, E. S.L., Mayeur, D., van Mens, T. E., Mohr, K., Mooijaart, S. P., Murtagh, F. E.M., Nelson, A., Nielsen, P. B., Ording, A. G., Ørskov, M., Pearson, M., Poenou, G., Portielje, J. E.A., Raczkiewicz, D., Rasmussen, K., Trinks-Roerdink, E., Schippers, I., Seddon, K., Sexton, K., Sivell, S., Skjøth, F., Søgaard, M., Szmit, S., Trompet, S., Vassal, P., Visser, C., van Vliet, L. M., Wilson, E., Klok, F. A., Noble, S. I.R., Goedegebuur, J., Abbel, D., Accassat, S., Achterberg, W. P., Akbari, A., Arfuch, V. M., Baddeley, E., Bax, J. J., Becker, D., Bergmeijer, B., Bertoletti, L., Blom, J. W., Calvetti, A., Cannegieter, S. C., Castro, L., Chavannes, N. H., Coma-Auli, N., Couffignal, C., Edwards, A., Edwards, M., Enggaard, H., Font, C., Gava, A., Geersing, G. J., Geijteman, E. C.T., Greenley, S., Gregory, C., Gussekloo, J., Hoffmann, I., Højen, A. A., van den Hout, W. B., Huisman, M. V., Jacobsen, S., Jagosh, J., Johnson, M. J., Jørgensen, L., Juffermans, C. C.M., Kempers, E. K., Konstantinides, S., Kroder, A. F., Kruip, M. J.H.A., Lafaie, L., Langendoen, J. W., Larsen, T. B., Lifford, K., van der Linden, Y. M., Mahé, I., Maiorana, L., Maraveyas, A., Martens, E. S.L., Mayeur, D., van Mens, T. E., Mohr, K., Mooijaart, S. P., Murtagh, F. E.M., Nelson, A., Nielsen, P. B., Ording, A. G., Ørskov, M., Pearson, M., Poenou, G., Portielje, J. E.A., Raczkiewicz, D., Rasmussen, K., Trinks-Roerdink, E., Schippers, I., Seddon, K., Sexton, K., Sivell, S., Skjøth, F., Søgaard, M., Szmit, S., Trompet, S., Vassal, P., Visser, C., van Vliet, L. M., Wilson, E., Klok, F. A., and Noble, S. I.R.

Abstract

Background: Even though antithrombotic therapy has probably little or even negative effects on the well-being of people with cancer during their last year of life, deprescribing antithrombotic therapy at the end of life is rare in practice. It is often continued until death, possibly resulting in excess bleeding, an increased disease burden and higher healthcare costs. Methods: The SERENITY consortium comprises researchers and clinicians from eight European countries with specialties in different clinical fields, epidemiology and psychology. SERENITY will use a comprehensive approach combining a realist review, flash mob research, epidemiological studies, and qualitative interviews. The results of these studies will be used in a Delphi process to reach a consensus on the optimal design of the shared decision support tool. Next, the shared decision support tool will be tested in a randomised controlled trial. A targeted implementation and dissemination plan will be developed to enable the use of the SERENITY tool across Europe, as well as its incorporation in clinical guidelines and policies. The entire project is funded by Horizon Europe. Results: SERENITY will develop an information-driven shared decision support tool that will facilitate treatment decisions regarding the appropriate use of antithrombotic therapy in people with cancer at the end of life. Conclusions: We aim to develop an intervention that guides the appropriate use of antithrombotic therapy, prevents bleeding complications, and saves healthcare costs. Hopefully, usage of the tool leads to enhanced empowerment and improved quality of life and treatment satisfaction of people with advanced cancer and their care givers.

Published
2023

4. ‘’Girls who like girls’’: Using affordances for queer activism on TikTok

Author

Cohen, Y., Blom, J. (Thesis Advisor), Cohen, Y., and Blom, J. (Thesis Advisor)

Abstract

TikTok, a social media platform for sharing short videos, has become an increasingly popular venue for queer online activism, as people use it to fight against discrimination and to normalize the existence of LGBTQ+ identities. In one such instance, a number of queer women protested against a trend they deemed problematic. This trend, referred to as the ‘’girls who like girls’’ trend, consisted of men lip-syncing and dancing to a song about women who are attracted to women, which a lot of queer women considered to be perpetuating sexual objectification. This issue has negatively affected queer women for ages, as they have often been seen and presented by the media as merely objects to be looked at through the male gaze, and their attraction to women as only existing for heterosexual men’s pleasure. This case study provides a clear example of how queer women can actively speak up against sexual objectification, by using the affordances of the TikTok app – specifically the affordances of easy creation, direct interaction, sound choice and hashtags. In this thesis, twenty of the protest videos made in response to the controversial ‘’girls who like girls’’ trend are examined through a qualitative content analysis – a form of textual analysis. I argue that queer women on TikTok use the affordances of the app to fight against sexual objectification by employing three strategies of queer activism: calling out problematic phenomena and behavior, connecting with community to create queer spaces, and producing representation through self-expression. These findings shed a light on the various ways in which social media can be used for the purposes of queer activism.

Published
2021

5. ‘’Girls who like girls’’: Using affordances for queer activism on TikTok

Author

Cohen, Y., Blom, J. (Thesis Advisor), Cohen, Y., and Blom, J. (Thesis Advisor)

Abstract

TikTok, a social media platform for sharing short videos, has become an increasingly popular venue for queer online activism, as people use it to fight against discrimination and to normalize the existence of LGBTQ+ identities. In one such instance, a number of queer women protested against a trend they deemed problematic. This trend, referred to as the ‘’girls who like girls’’ trend, consisted of men lip-syncing and dancing to a song about women who are attracted to women, which a lot of queer women considered to be perpetuating sexual objectification. This issue has negatively affected queer women for ages, as they have often been seen and presented by the media as merely objects to be looked at through the male gaze, and their attraction to women as only existing for heterosexual men’s pleasure. This case study provides a clear example of how queer women can actively speak up against sexual objectification, by using the affordances of the TikTok app – specifically the affordances of easy creation, direct interaction, sound choice and hashtags. In this thesis, twenty of the protest videos made in response to the controversial ‘’girls who like girls’’ trend are examined through a qualitative content analysis – a form of textual analysis. I argue that queer women on TikTok use the affordances of the app to fight against sexual objectification by employing three strategies of queer activism: calling out problematic phenomena and behavior, connecting with community to create queer spaces, and producing representation through self-expression. These findings shed a light on the various ways in which social media can be used for the purposes of queer activism.

Published
2021

6. International Law Association’s Guidelines on Intellectual Property and Private International Law (“Kyoto Guidelines”): Jurisdiction

Author

Blom, J, Dreyfuss, R, Jurcys, P, Metzger, A, Moura Vicente, D, Schaafsma, S, Ubertazzi, B, Dreyfuss, RC, Jurcys, P., Schaafsma, SJ, Blom, J, Dreyfuss, R, Jurcys, P, Metzger, A, Moura Vicente, D, Schaafsma, S, Ubertazzi, B, Dreyfuss, RC, Jurcys, P., and Schaafsma, SJ

Abstract

The chapter “Jurisdiction” of the International Law Association’s Guidelines on Intellectual Property and Private International Law (“Kyoto Guidelines”) provides where international intellectual property claims can be brought to court. It defines the basic forum at the defendants domicile and alternative fora for contractual, infringement and other kinds of claims. It also provides grounds that should be taken as insufficient for the granting of jurisdiction. The chapter states to what extent validity and registration claims should be subject to exclusive jurisdiction. Finally, it comprises Guidelines for the coordination of claims pending before different courts.

Published
2021

7. Rastafari-symboliek in Christiania

Author

Blom, J., Frederiks, M. T. (Thesis Advisor), Blom, J., and Frederiks, M. T. (Thesis Advisor)

Abstract

Opvallend genoeg worden er in de Kopenhaagse vrijstaat Christiania religieuze symbolen uit de rastafari-cultuur gebruikt, zonder dat dit in een religieuze setting gebeurt. Deze scriptie onderzoekt welke betekenissen er achter symbolen schuilgaat. Tijdens een zestal bezoeken aan Christiania in de zomer van 2019 is er een inventarisatie ontstaan van de aanwezige rastafari-symbolen. Aan de hand van deze inventarisatie worden zowel de ‘originele’ als de alternatieve betekenissen van de symboliek besproken. Om een zo volledig mogelijk beeld te geven van de contexten waarin deze betekenissen worden verleend, wordt er een beeld geschetst van de rastafari-cultuur en de Christiania-gemeenschap. Van de rastafari wordt een beeld geschetst van de geschiedenis en gebruiken, en bij Christiania komen de politieke geschiedenis, ideologie en de drugscultuur aan bod. Uit de bevindingen van dit onderzoek blijkt dat de rastafari-symboliek in Christiania niet op een religieuze manier wordt gebruikt, maar dat het wordt ingezet voor commerciële doeleinden en ter uitdraging van een politieke anti-establishmenthouding. Daarbij worden aspecten van de rastafari, die vaak zowel een politieke als religieuze lading hebben, selectief overgenomen en vervolgens geseculariseerd.

Published
2020

8. Rastafari-symboliek in Christiania

Author

Blom, J., Frederiks, M. T. (Thesis Advisor), Blom, J., and Frederiks, M. T. (Thesis Advisor)

Abstract

Opvallend genoeg worden er in de Kopenhaagse vrijstaat Christiania religieuze symbolen uit de rastafari-cultuur gebruikt, zonder dat dit in een religieuze setting gebeurt. Deze scriptie onderzoekt welke betekenissen er achter symbolen schuilgaat. Tijdens een zestal bezoeken aan Christiania in de zomer van 2019 is er een inventarisatie ontstaan van de aanwezige rastafari-symbolen. Aan de hand van deze inventarisatie worden zowel de ‘originele’ als de alternatieve betekenissen van de symboliek besproken. Om een zo volledig mogelijk beeld te geven van de contexten waarin deze betekenissen worden verleend, wordt er een beeld geschetst van de rastafari-cultuur en de Christiania-gemeenschap. Van de rastafari wordt een beeld geschetst van de geschiedenis en gebruiken, en bij Christiania komen de politieke geschiedenis, ideologie en de drugscultuur aan bod. Uit de bevindingen van dit onderzoek blijkt dat de rastafari-symboliek in Christiania niet op een religieuze manier wordt gebruikt, maar dat het wordt ingezet voor commerciële doeleinden en ter uitdraging van een politieke anti-establishmenthouding. Daarbij worden aspecten van de rastafari, die vaak zowel een politieke als religieuze lading hebben, selectief overgenomen en vervolgens geseculariseerd.

Published
2020

9. Evidence supporting the best clinical management of patients with multimorbidity and polypharmacy : a systematic guideline review and expert consensus

Author

Muth, C., Blom, J. W., Smith, S. M., Johnell, Kristina, Gonzalez-Gonzalez, A. I., Nguyen, T. S., Brueckle, M. -S., Cesari, M., Tinetti, M. E., Valderas, J. M., Muth, C., Blom, J. W., Smith, S. M., Johnell, Kristina, Gonzalez-Gonzalez, A. I., Nguyen, T. S., Brueckle, M. -S., Cesari, M., Tinetti, M. E., and Valderas, J. M.

Abstract

The complexity and heterogeneity of patients with multimorbidity and polypharmacy renders traditional disease-oriented guidelines often inadequate and complicates clinical decision making. To address this challenge, guidelines have been developed on multimorbidity or polypharmacy. To systematically analyse their recommendations, we conducted a systematic guideline review using the Ariadne principles for managing multimorbidity as analytical framework. The information synthesis included a multistep consensus process involving 18 multidisciplinary experts from seven countries. We included eight guidelines (four each on multimorbidity and polypharmacy) and extracted about 250 recommendations. The guideline addressed (i) the identification of the target population (risk factors); (ii) the assessment of interacting conditions and treatments: medical history, clinical and psychosocial assessment including physiological status and frailty, reviews of medication and encounters with healthcare providers highlighting informational continuity; (iii) the need to incorporate patient preferences and goal setting: eliciting preferences and expectations, the process of shared decision making in relation to treatment options and the level of involvement of patients and carers; (iv) individualized management: guiding principles on optimization of treatment benefits over possible harms, treatment communication and the information content of medication/care plans; (v) monitoring and follow-up: strategies in care planning, self-management and medication-related aspects, communication with patients including safety instructions and adherence, coordination of care regarding referral and discharge management, medication appropriateness and safety concerns. The spectrum of clinical and self-management issues varied from guiding principles to specific recommendations and tools providing actionable support. The limited availability of reliable risk prediction models, feasible interventions of

Published
2019
Full Text
View/download PDF

10. Health-Related Preferences of Older Patients with Multimorbidity: an Evidence Map

Author

González-González, AI, Schmucker, C, Nothacker, J, Nguyen, TS, Brueckle, MS, Blom, J, van den Akker, M, Meerpohl, J, Röttger, K, Wegwarth, O, Hoffmann, T, Straus, S, Gerlach, F, Muth, C, González-González, AI, Schmucker, C, Nothacker, J, Nguyen, TS, Brueckle, MS, Blom, J, van den Akker, M, Meerpohl, J, Röttger, K, Wegwarth, O, Hoffmann, T, Straus, S, Gerlach, F, and Muth, C

Published
2019

11. Health-Related Preferences of Older Patients with Multimorbidity: an Evidence Map

Author

González-González, AI, Schmucker, C, Nothacker, J, Nguyen, TS, Brueckle, MS, Blom, J, van den Akker, M, Meerpohl, J, Röttger, K, Wegwarth, O, Hoffmann, T, Straus, S, Gerlach, F, Muth, C, González-González, AI, Schmucker, C, Nothacker, J, Nguyen, TS, Brueckle, MS, Blom, J, van den Akker, M, Meerpohl, J, Röttger, K, Wegwarth, O, Hoffmann, T, Straus, S, Gerlach, F, and Muth, C

Published
2019

13. Effectiveness and cost-effectiveness of proactive and multidisciplinary integrated care for older people with complex problems in general practice: an individual participant data meta-analysis

Author

Blom, J. W., Van den Hout, W. B., Den Elzen, W. P. J., Drewes, Y. M., Bleijenberg, N., Fabbricotti, I. N., Jansen, A. P. D., Kempen, G. I. J. M., Koopmans, R., Looman, W. M., Melis, R. J. F., Metzelthin, S. F., van Charante, E. P. Moll, Muntinga, M. E., Numans, M. E., Ruikes, F. G. H., Spoorenberg, S. L. W., Stijnen, T., Suijker, J. J., De Wit, N. J., Wynia, K., Wind, A. W., Gussekloo, J., Blom, J. W., Van den Hout, W. B., Den Elzen, W. P. J., Drewes, Y. M., Bleijenberg, N., Fabbricotti, I. N., Jansen, A. P. D., Kempen, G. I. J. M., Koopmans, R., Looman, W. M., Melis, R. J. F., Metzelthin, S. F., van Charante, E. P. Moll, Muntinga, M. E., Numans, M. E., Ruikes, F. G. H., Spoorenberg, S. L. W., Stijnen, T., Suijker, J. J., De Wit, N. J., Wynia, K., Wind, A. W., and Gussekloo, J.

Published
2018

14. Effectiveness and cost-effectiveness of proactive and multidisciplinary integrated care for older people with complex problems in general practice: an individual participant data meta-analysis

Author

Blom, J. W., Van den Hout, W. B., Den Elzen, W. P. J., Drewes, Y. M., Bleijenberg, N., Fabbricotti, I. N., Jansen, A. P. D., Kempen, G. I. J. M., Koopmans, R., Looman, W. M., Melis, R. J. F., Metzelthin, S. F., van Charante, E. P. Moll, Muntinga, M. E., Numans, M. E., Ruikes, F. G. H., Spoorenberg, S. L. W., Stijnen, T., Suijker, J. J., De Wit, N. J., Wynia, K., Wind, A. W., Gussekloo, J., Blom, J. W., Van den Hout, W. B., Den Elzen, W. P. J., Drewes, Y. M., Bleijenberg, N., Fabbricotti, I. N., Jansen, A. P. D., Kempen, G. I. J. M., Koopmans, R., Looman, W. M., Melis, R. J. F., Metzelthin, S. F., van Charante, E. P. Moll, Muntinga, M. E., Numans, M. E., Ruikes, F. G. H., Spoorenberg, S. L. W., Stijnen, T., Suijker, J. J., De Wit, N. J., Wynia, K., Wind, A. W., and Gussekloo, J.

Published
2018

16. Effectiveness and cost-effectiveness of proactive and multidisciplinary integrated care for older people with complex problems in general practice: an individual participant data meta-analysis

Author

Blom, J. W., Van den Hout, W. B., Den Elzen, W. P. J., Drewes, Y. M., Bleijenberg, N., Fabbricotti, I. N., Jansen, A. P. D., Kempen, G. I. J. M., Koopmans, R., Looman, W. M., Melis, R. J. F., Metzelthin, S. F., van Charante, E. P. Moll, Muntinga, M. E., Numans, M. E., Ruikes, F. G. H., Spoorenberg, S. L. W., Stijnen, T., Suijker, J. J., De Wit, N. J., Wynia, K., Wind, A. W., Gussekloo, J., Blom, J. W., Van den Hout, W. B., Den Elzen, W. P. J., Drewes, Y. M., Bleijenberg, N., Fabbricotti, I. N., Jansen, A. P. D., Kempen, G. I. J. M., Koopmans, R., Looman, W. M., Melis, R. J. F., Metzelthin, S. F., van Charante, E. P. Moll, Muntinga, M. E., Numans, M. E., Ruikes, F. G. H., Spoorenberg, S. L. W., Stijnen, T., Suijker, J. J., De Wit, N. J., Wynia, K., Wind, A. W., and Gussekloo, J.

Published
2018

17. Effectiveness and cost-effectiveness of proactive and multidisciplinary integrated care for older people with complex problems in general practice: an individual participant data meta-analysis

Author

Verplegingswetenschap, Infection & Immunity, Unit Opleiding Aios, Medische staf Anesthesiologie, HAG Netwerken, General Practice & Nursing Science, Child Health, Cancer, JC Overig onderzoek, Blom, J. W., Van den Hout, W. B., Den Elzen, W. P. J., Drewes, Y. M., Bleijenberg, N., Fabbricotti, I. N., Jansen, A. P. D., Kempen, G. I. J. M., Koopmans, R., Looman, W. M., Melis, R. J. F., Metzelthin, S. F., van Charante, E. P. Moll, Muntinga, M. E., Numans, M. E., Ruikes, F. G. H., Spoorenberg, S. L. W., Stijnen, T., Suijker, J. J., De Wit, N. J., Wynia, K., Wind, A. W., Gussekloo, J., Verplegingswetenschap, Infection & Immunity, Unit Opleiding Aios, Medische staf Anesthesiologie, HAG Netwerken, General Practice & Nursing Science, Child Health, Cancer, JC Overig onderzoek, Blom, J. W., Van den Hout, W. B., Den Elzen, W. P. J., Drewes, Y. M., Bleijenberg, N., Fabbricotti, I. N., Jansen, A. P. D., Kempen, G. I. J. M., Koopmans, R., Looman, W. M., Melis, R. J. F., Metzelthin, S. F., van Charante, E. P. Moll, Muntinga, M. E., Numans, M. E., Ruikes, F. G. H., Spoorenberg, S. L. W., Stijnen, T., Suijker, J. J., De Wit, N. J., Wynia, K., Wind, A. W., and Gussekloo, J.

Published
2018

18. Fine-scale mapping of the 4q24 locus identifies & pr two Independent loci associated with breast cancer risk

Author

Guo, X. (Xingyi), Long, J. (Jirong), Zeng, C. (Chenjie), Michailidou, K. (Kyriaki), Ghoussaini, M. (Maya), Bolla, M.K. (Manjeet), Wang, Q. (Qing), Milne, R.L. (Roger L.), Shu, X.-O. (Xiao-Ou), Cai, Q. (Qiuyin), Beesley, J. (Jonathan), Kar, S. (Siddhartha), Andrulis, I.L. (Irene), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Beckmann, M.W. (Matthias), Beeghly-Fadiel, A. (Alicia), Benítez, J. (Javier), Blot, W.J. (William), Bogdanova, N.V. (Natalia), Bojesen, S.E. (Stig), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brinton, L.A. (Louise), Broekss, A. (Annegien), Brüning, T. (Thomas), Burwinkel, B. (Barbara), Cai, H. (Hui), Canisius, S. (Sander), Chang-Claude, J. (Jenny), Choi, J.-Y. (J.), Couch, F.J. (Fergus), Cox, A. (Angela), Cross, S.S. (Simon), Czene, K. (Kamila), Darabi, H. (Hatef), Devilee, P. (Peter), Droit, A. (Arnaud), Dörk, T. (Thilo), Fasching, P.A. (Peter), Fletcher, O. (Olivia), Flyger, H. (Henrik), Fostira, F. (Florentia), Gaborieau, V. (Valerie), García-Closas, M. (Montserrat), Giles, G.G. (Graham G.), Grip, M. (Mervi), Guénel, P. (Pascal), Haiman, C.A. (Christopher A.), Hamann, U. (Ute), Hartman, J.M. (Joost), Hollestelle, A. (Antoinette), Hopper, J.L. (John L.), Hsiung, C.-N. (Chia-Ni), Ito, H. (Hidemi), Jakubowska, A. (Anna), Johnson, N. (Nichola), Kabisch, M. (Maria), Kang, D. (Daehee), Khan, S. (Sofia), Knight, J.A. (Julia), Kosma, V-M. (Veli-Matti), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Li, J. (Jingmei), Lindblom, A. (Annika), Lophatananon, A. (Artitaya), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Marme, F. (Federick), Matsuo, K. (Keitaro), McLean, C.A. (Catriona Ann), Meindl, A. (Alfons), Muir, K. (Kenneth), Neuhausen, S.L. (Susan), Nevanlinna, H. (Heli), Nord, S. (Silje), Olson, J.E. (Janet), Orr, N. (Nick), Peterlongo, P. (Paolo), Putti, T.C. (Thomas Choudary), Rudolph, A. (Anja), Sangrajrang, S. (Suleeporn), Sawyer, E.J. (Elinor), Schmidt, M.K. (Marjanka), Schmutzler, R.K. (Rita), Shen, C-Y. (Chen-Yang), Shi, J. (Jiajun), Shrubsole, M. (Martha), Southey, M.C. (Melissa), Swerdlow, A.J. (Anthony ), Teo, S.H. (Soo Hwang), Thienpont, B. (Bernard), Toland, A.E. (Amanda), Tollenaar, R.A.E.M. (Rob), Tomlinson, I. (Ian), Truong, T. (Thérèse), Tseng, C.-C. (Chiu-chen), Ouweland, A.M.W. (Ans) van den, Wen, W. (Wanqing), Winqvist, R. (Robert), Wu, A. (Anna), Yip, C.H. (Cheng Har), Zamora, M.P. (Pilar), Zheng, Y. (Ying), Hall, P. (Per), Pharoah, P.D.P. (Paul), Simard, J. (Jacques), Chenevix-Trench, G. (Georgia), Dunning, A.M. (Alison), Easton, D.F. (Douglas F.), Zheng, W. (Wei), Eeles, R. (Rosalind), Al Olama, A.A. (Ali Amin), Kote-Jarai, Z., Benlloch, S. (Sara), Antoniou, A.C. (Antonis), McGuffog, L. (Lesley), Offit, K. (Kenneth), Lee, A. (Andrew), Dicks, E. (Ed), Luccarini, C. (Craig), Tessier, D.C. (Daniel C.), Bacot, F. (Francois), Vincent, D. (Daniel), La Boissière, S. (Sylvie), Robidoux, F. (Frederic), Nielsen, S.F. (Sune), Cunningham, J.M. (Julie), Windebank, S.A. (Sharon A.), Hilker, C.A. (Christopher A.), Meyer, J. (Jeffrey), Angelakos, M. (Maggie), Maskiell, J. (Judi), Rutgers, E.J. (Emiel J.), Verhoef, S., Hogervorst, F.B.L. (Frans), Boonyawongviroj, P. (Prat), Siriwanarungsan, P. (Pornthep), Schrauder, A. (André), Rübner, M. (Matthias), Oeser, S. (Sonja), Landrith, S. (Silke), Williams, E. (Eileen), Ryder-Mills, E. (Elaine), Sargus, K. (Kara), McInerney, N. (Niall), Colleran, G. (Gabrielle), Rowan, A. (Andrew), Jones, A. (Angela), Sohn, C. (Christof), Schneeweiß, A. (Andeas), Bugert, P. (Peter), Álvarez, N. (Nuria), Bernstein, L. (Leslie), Lacey, J. (James), Wang, S. (Sophia), Ma, H. (Huiyan), Lu, Y. (Yani), Clague De Hart, J. (Jessica), Deapen, D. (Dennis), Pinder, R. (Rich), Lee, E. (Eunjung), Schumacher, F.R. (Fredrick), Horn-Ross, P. (Pam), Reynolds, P. (Peggy), Nelson, D. (David), Park, H. (Hannah), Ziegler, H. (Hartwig), Wolf, S. (Sonja), Hermann, V. (Volker), Lo, W.-Y. (Wing-Yee), Justenhoven, C. (Christina), Ko, Y.-D. (Yon-Dschun), Baisch, C. (Christian), Fischer, H.-P. (Hans-Peter), Pesch, B. (Beate), Rabstein, S. (Sylvia), Lotz, A. (Anne), Harth, V. (Volker), Heikkinen, T. (Tuomas), Erkkilä, I. (Irja), Aaltonen, K. (Kirsimari), Smitten, K. (Karl) von, Antonenkova, N.N. (Natalia), Hillemanns, P. (Peter), Christiansen, H. (Hans), Myöhänen, E. (Eija), Kemiläinen, H. (Helena), Thorne, H. (Heather), Niedermayr, E. (Eveline), Bowtell, D., De Fazio, A. (Anna), Gertig, D., Green, A., Webb, P. (Penny), Parsons, P., Hayward, N., Webb, P.M. (P.), Whiteman, D., Fung, A. (Annie), Yashiki, J. (June), Peuteman, G. (Gilian), Smeets, D. (Dominiek), Van Brussel, T. (Thomas), Corthouts, K. (Kathleen), Obi, N. (Nadia), Heinz, J. (Judith), Behrens, T.W. (Timothy), Eilber, U. (Ursula), Celik, M. (Muhabbet), Olchers, T. (Til), Peissel, B. (Bernard), Scuvera, G. (Giulietta), Zaffaroni, D. (Daniela), Bonnani, B. (Bernardo), Feroce, I. (Irene), Maniscalco, A. (Angela), Rossi, A. (Alessandra), Bernard, L. (Loris), Tranchant, M. (Martine), Valois, M.-F. (Marie-France), Turgeon, A. (Annie), Heguy, L. (Lea), Yee, P.S. (Phuah Sze), Kang, P. (Peter), Nee, K.I. (Kang In), Mariapun, S. (Shivaani), Sook-Yee, Y. (Yoon), Lee, D.S.C. (Daphne S.C.), Ching, T.Y. (Teh Yew), Taib, N.A.M. (Nur Aishah Mohd), Otsukka, M. (Meeri), Mononen, K. (Kari), Selander, T. (Teresa), Weerasooriya, N. (Nayana), Krol-Warmerdam, E.M.M. (Elly), Molenaar, J., Blom, J., Szeszenia-Dabrowska, N. (Neonilia), Peplonska, B. (Beata), Zatonski, W. (Witold), Chao, P. (Pei), Stagner, M. (Michael), Bos, P. (Petra), Blom, J. (Jannet), Crepin, E. (Ellen), Nieuwlaat, A. (Anja), Heemskerk, A. (Annette), Higham, S. (Sue), Cramp, H.E. (Helen), Connley, D. (Daniel), Balasubramanian, S. (Sabapathy), Brock, I.W. (Ian), Kerin, M. (Michael), Miller, N. (Nicola), Kerbrat, P. (Pierre), Arveux, P. (Patrick), Le Scodan, R. (Romuald), Raoul, Y. (Yves), Laurent-Puig, P. (Pierre), Mulot, C. (Claire), Stegmaier, C. (Christa), Butterbach, K. (Katja), Karstens, J.H. (Johann), Flesch-Janys, D. (Dieter), Seibold, P. (Petra), Vrieling, A. (Alina), Nickels, S. (Stefan), Radice, P. (Paolo), Pykäs, K. (Katri), Jukkola-Vuorinen, A. (Arja), Kauppila, S. (Saila), Conroy, D. (Don), Baynes, C. (Caroline), Chua, K. (Kimberley), Pilarski, R. (Robert), Guo, X. (Xingyi), Long, J. (Jirong), Zeng, C. (Chenjie), Michailidou, K. (Kyriaki), Ghoussaini, M. (Maya), Bolla, M.K. (Manjeet), Wang, Q. (Qing), Milne, R.L. (Roger L.), Shu, X.-O. (Xiao-Ou), Cai, Q. (Qiuyin), Beesley, J. (Jonathan), Kar, S. (Siddhartha), Andrulis, I.L. (Irene), Anton-Culver, H. (Hoda), Arndt, V. (Volker), Beckmann, M.W. (Matthias), Beeghly-Fadiel, A. (Alicia), Benítez, J. (Javier), Blot, W.J. (William), Bogdanova, N.V. (Natalia), Bojesen, S.E. (Stig), Brauch, H. (Hiltrud), Brenner, H. (Hermann), Brinton, L.A. (Louise), Broekss, A. (Annegien), Brüning, T. (Thomas), Burwinkel, B. (Barbara), Cai, H. (Hui), Canisius, S. (Sander), Chang-Claude, J. (Jenny), Choi, J.-Y. (J.), Couch, F.J. (Fergus), Cox, A. (Angela), Cross, S.S. (Simon), Czene, K. (Kamila), Darabi, H. (Hatef), Devilee, P. (Peter), Droit, A. (Arnaud), Dörk, T. (Thilo), Fasching, P.A. (Peter), Fletcher, O. (Olivia), Flyger, H. (Henrik), Fostira, F. (Florentia), Gaborieau, V. (Valerie), García-Closas, M. (Montserrat), Giles, G.G. (Graham G.), Grip, M. (Mervi), Guénel, P. (Pascal), Haiman, C.A. (Christopher A.), Hamann, U. (Ute), Hartman, J.M. (Joost), Hollestelle, A. (Antoinette), Hopper, J.L. (John L.), Hsiung, C.-N. (Chia-Ni), Ito, H. (Hidemi), Jakubowska, A. (Anna), Johnson, N. (Nichola), Kabisch, M. (Maria), Kang, D. (Daehee), Khan, S. (Sofia), Knight, J.A. (Julia), Kosma, V-M. (Veli-Matti), Lambrechts, D. (Diether), Le Marchand, L. (Loic), Li, J. (Jingmei), Lindblom, A. (Annika), Lophatananon, A. (Artitaya), Lubinski, J. (Jan), Mannermaa, A. (Arto), Manoukian, S. (Siranoush), Margolin, S. (Sara), Marme, F. (Federick), Matsuo, K. (Keitaro), McLean, C.A. (Catriona Ann), Meindl, A. (Alfons), Muir, K. (Kenneth), Neuhausen, S.L. (Susan), Nevanlinna, H. (Heli), Nord, S. (Silje), Olson, J.E. (Janet), Orr, N. (Nick), Peterlongo, P. (Paolo), Putti, T.C. (Thomas Choudary), Rudolph, A. (Anja), Sangrajrang, S. (Suleeporn), Sawyer, E.J. (Elinor), Schmidt, M.K. (Marjanka), Schmutzler, R.K. (Rita), Shen, C-Y. (Chen-Yang), Shi, J. (Jiajun), Shrubsole, M. (Martha), Southey, M.C. (Melissa), Swerdlow, A.J. (Anthony ), Teo, S.H. (Soo Hwang), Thienpont, B. (Bernard), Toland, A.E. (Amanda), Tollenaar, R.A.E.M. (Rob), Tomlinson, I. (Ian), Truong, T. (Thérèse), Tseng, C.-C. (Chiu-chen), Ouweland, A.M.W. (Ans) van den, Wen, W. (Wanqing), Winqvist, R. (Robert), Wu, A. (Anna), Yip, C.H. (Cheng Har), Zamora, M.P. (Pilar), Zheng, Y. (Ying), Hall, P. (Per), Pharoah, P.D.P. (Paul), Simard, J. (Jacques), Chenevix-Trench, G. (Georgia), Dunning, A.M. (Alison), Easton, D.F. (Douglas F.), Zheng, W. (Wei), Eeles, R. (Rosalind), Al Olama, A.A. (Ali Amin), Kote-Jarai, Z., Benlloch, S. (Sara), Antoniou, A.C. (Antonis), McGuffog, L. (Lesley), Offit, K. (Kenneth), Lee, A. (Andrew), Dicks, E. (Ed), Luccarini, C. (Craig), Tessier, D.C. (Daniel C.), Bacot, F. (Francois), Vincent, D. (Daniel), La Boissière, S. (Sylvie), Robidoux, F. (Frederic), Nielsen, S.F. (Sune), Cunningham, J.M. (Julie), Windebank, S.A. (Sharon A.), Hilker, C.A. (Christopher A.), Meyer, J. (Jeffrey), Angelakos, M. (Maggie), Maskiell, J. (Judi), Rutgers, E.J. (Emiel J.), Verhoef, S., Hogervorst, F.B.L. (Frans), Boonyawongviroj, P. (Prat), Siriwanarungsan, P. (Pornthep), Schrauder, A. (André), Rübner, M. (Matthias), Oeser, S. (Sonja), Landrith, S. (Silke), Williams, E. (Eileen), Ryder-Mills, E. (Elaine), Sargus, K. (Kara), McInerney, N. (Niall), Colleran, G. (Gabrielle), Rowan, A. (Andrew), Jones, A. (Angela), Sohn, C. (Christof), Schneeweiß, A. (Andeas), Bugert, P. (Peter), Álvarez, N. (Nuria), Bernstein, L. (Leslie), Lacey, J. (James), Wang, S. (Sophia), Ma, H. (Huiyan), Lu, Y. (Yani), Clague De Hart, J. (Jessica), Deapen, D. (Dennis), Pinder, R. (Rich), Lee, E. (Eunjung), Schumacher, F.R. (Fredrick), Horn-Ross, P. (Pam), Reynolds, P. (Peggy), Nelson, D. (David), Park, H. (Hannah), Ziegler, H. (Hartwig), Wolf, S. (Sonja), Hermann, V. (Volker), Lo, W.-Y. (Wing-Yee), Justenhoven, C. (Christina), Ko, Y.-D. (Yon-Dschun), Baisch, C. (Christian), Fischer, H.-P. (Hans-Peter), Pesch, B. (Beate), Rabstein, S. (Sylvia), Lotz, A. (Anne), Harth, V. (Volker), Heikkinen, T. (Tuomas), Erkkilä, I. (Irja), Aaltonen, K. (Kirsimari), Smitten, K. (Karl) von, Antonenkova, N.N. (Natalia), Hillemanns, P. (Peter), Christiansen, H. (Hans), Myöhänen, E. (Eija), Kemiläinen, H. (Helena), Thorne, H. (Heather), Niedermayr, E. (Eveline), Bowtell, D., De Fazio, A. (Anna), Gertig, D., Green, A., Webb, P. (Penny), Parsons, P., Hayward, N., Webb, P.M. (P.), Whiteman, D., Fung, A. (Annie), Yashiki, J. (June), Peuteman, G. (Gilian), Smeets, D. (Dominiek), Van Brussel, T. (Thomas), Corthouts, K. (Kathleen), Obi, N. (Nadia), Heinz, J. (Judith), Behrens, T.W. (Timothy), Eilber, U. (Ursula), Celik, M. (Muhabbet), Olchers, T. (Til), Peissel, B. (Bernard), Scuvera, G. (Giulietta), Zaffaroni, D. (Daniela), Bonnani, B. (Bernardo), Feroce, I. (Irene), Maniscalco, A. (Angela), Rossi, A. (Alessandra), Bernard, L. (Loris), Tranchant, M. (Martine), Valois, M.-F. (Marie-France), Turgeon, A. (Annie), Heguy, L. (Lea), Yee, P.S. (Phuah Sze), Kang, P. (Peter), Nee, K.I. (Kang In), Mariapun, S. (Shivaani), Sook-Yee, Y. (Yoon), Lee, D.S.C. (Daphne S.C.), Ching, T.Y. (Teh Yew), Taib, N.A.M. (Nur Aishah Mohd), Otsukka, M. (Meeri), Mononen, K. (Kari), Selander, T. (Teresa), Weerasooriya, N. (Nayana), Krol-Warmerdam, E.M.M. (Elly), Molenaar, J., Blom, J., Szeszenia-Dabrowska, N. (Neonilia), Peplonska, B. (Beata), Zatonski, W. (Witold), Chao, P. (Pei), Stagner, M. (Michael), Bos, P. (Petra), Blom, J. (Jannet), Crepin, E. (Ellen), Nieuwlaat, A. (Anja), Heemskerk, A. (Annette), Higham, S. (Sue), Cramp, H.E. (Helen), Connley, D. (Daniel), Balasubramanian, S. (Sabapathy), Brock, I.W. (Ian), Kerin, M. (Michael), Miller, N. (Nicola), Kerbrat, P. (Pierre), Arveux, P. (Patrick), Le Scodan, R. (Romuald), Raoul, Y. (Yves), Laurent-Puig, P. (Pierre), Mulot, C. (Claire), Stegmaier, C. (Christa), Butterbach, K. (Katja), Karstens, J.H. (Johann), Flesch-Janys, D. (Dieter), Seibold, P. (Petra), Vrieling, A. (Alina), Nickels, S. (Stefan), Radice, P. (Paolo), Pykäs, K. (Katri), Jukkola-Vuorinen, A. (Arja), Kauppila, S. (Saila), Conroy, D. (Don), Baynes, C. (Caroline), Chua, K. (Kimberley), and Pilarski, R. (Robert)

Abstract

Background: A recent association study identified a common variant (rs9790517) at 4q24 to be associated with breast cancer risk. Independent association signals and potential functional variants in this locus have not been explored. Methods: We conducted a fine-mapping analysis in 55,540 breast cancer cases and 51,168 controls from the Breast Cancer Association Consortium. Results: Conditional analyses identified two independent association signals among women of European ancestry, represented by rs9790517 [conditional P=2.51 × 10-4; OR, 1.04; 95% confidence interval (CI), 1.02-1.07] and rs77928427 (P=1.86 × 10-4; OR, 1.04; 95% CI, 1.02-1.07). Functional annotation using data from the Encyclopedia of DNA Elements (ENCODE) project revealed two putative functional variants, rs62331150 and rs73838678 in linkage disequilibrium (LD) with rs9790517 (r2≥ 0.90) residing in the active promoter or enhancer, respectively, of the nearest gene, TET2. Both variants are located in DNase I hypersensitivity and transcription factor-binding sites. Using data from both The Cancer Genome Atlas (TCGA) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC), we showed that rs62331150 was associated with level of expression of TET2 in breast normal and tumor tissue. Conclusion: Our study identified two independent association signals at 4q24 in relation to breast cancer risk and suggested that observed association in this locus may be mediated through the regulation of TET2. Impact: Fine-mapping study with large sample size warranted for identification of independent loci for breast cancer risk.

Published
2015
Full Text
View/download PDF

19. Benefits and Factors Influencing the Design of Intergenerational Digital Games: A Systematic Literature Review

Author

de la Hera Conde-Pumpido, T., Loos, E.F., Simons, M., Blom, J., de la Hera Conde-Pumpido, T., Loos, E.F., Simons, M., and Blom, J.

Abstract

The main purpose of this paper is to review the benefits and factors to be taken into consideration for the design of intergenerational digital games. We conducted a systematic in Scopus, Web of Science, PsicInfo, Pubmed and Science Direct, finally including 16 empirical studies written in English. Theidentifiedbenefitswerefoundtofallintofourmaincategories,i.e.,(1)reinforcingfamily bond, (2) enhancing reciprocal learning (3) increasing understanding of the other generation and (4) reducing social anxiety. According to the literature, two types of factors are important to take into consideration: player-centric and game-centric factors. We identified the nature of the interactions between older (55–81 year-olds) and younger players (4–22 year-olds), their motivations to play digital games and the difference in abilities as the main player-centric factors to take into account when designing intergenerational games. The most relevant game-centric factors were found to be goal-related and space-related forms of interaction. To gain more insight into how specific benefits of playing digital games are related to a type of game, gender or age of the participant, additional empirical studies (comparative analyses), that take these factors into account are needed.

Published
2017

20. From Tools to “Recipes”: Building a Media Suite within the Dutch Digital Humanities Infrastructure CLARIAH

Author

Martinez-Ortiz, Carlos, Ordelman, Roeland, Koolen, Marijn, Noordegraaf, J.J., Melgar, Liliana, Aroyo, Lora, Blom, J., van Gorp, J., Baaren, E., Beelen, K.J., Kiewik, R., Poell, T., Martinez-Ortiz, Carlos, Ordelman, Roeland, Koolen, Marijn, Noordegraaf, J.J., Melgar, Liliana, Aroyo, Lora, Blom, J., van Gorp, J., Baaren, E., Beelen, K.J., Kiewik, R., and Poell, T.

Published
2017

21. Measurement properties of the EQ-5D across four major geriatric conditions : Findings from TOPICS-MDS

Author

Lutomski, Jennifer E., Krabbe, Paul F M, Bleijenberg, N., Blom, Jeanett, Kempen, Gertrudis I J M, MacNeil-Vroomen, Janet, Muntinga, Maaike E., Steyerburg, Ewout, Olde Rikkert, Marcel G M, Melis, René J.F., Blom, J. W., Melis, R.J.F., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van den Brink, D., Lutomski, J.E., Qin, L., Kempen, G. I.J.M., Krabbe, P. F M, Buurman, B.M., van der Horst, H.E., de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., TOPICS Consortium, Lutomski, Jennifer E., Krabbe, Paul F M, Bleijenberg, N., Blom, Jeanett, Kempen, Gertrudis I J M, MacNeil-Vroomen, Janet, Muntinga, Maaike E., Steyerburg, Ewout, Olde Rikkert, Marcel G M, Melis, René J.F., Blom, J. W., Melis, R.J.F., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van den Brink, D., Lutomski, J.E., Qin, L., Kempen, G. I.J.M., Krabbe, P. F M, Buurman, B.M., van der Horst, H.E., de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., and TOPICS Consortium

Published
2017

22. Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS

Author

Lutomski, J.E., Krabbe, P.F.M., Bleijenberg, N., Blom, J., Kempen, G.I., MacNeil-Vroomen, J., Muntinga, M.E., Steyerburg, E., Olde-Rikkert, M.G.M., Melis, R.J.F., Lutomski, J.E., Krabbe, P.F.M., Bleijenberg, N., Blom, J., Kempen, G.I., MacNeil-Vroomen, J., Muntinga, M.E., Steyerburg, E., Olde-Rikkert, M.G.M., and Melis, R.J.F.

Abstract

Contains fulltext : 169741.pdf (publisher's version ) (Open Access), BACKGROUND: As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D (a common HRQoL instrument) across four major chronic geriatric conditions: hearing issues, joint damage, urinary incontinence, or dizziness with falls. METHODS: The study sample comprised 25,637 community-dwelling persons aged 65 years and older residing in the Netherlands (Data source: TOPICS-MDS, www.topics-mds.eu ). Floor and ceiling effects were examined. To assess convergent validity, random effects meta-correlations (Spearman's rho) were derived between individual EQ-5D domains and related survey items. To further examine construct validity, the association between sociodemographic characteristics and EQ-5D summary scores were assessed using linear mixed models. Outcomes were compared to the overall study population as well as a 'healthy' subgroup reporting no major chronic conditions. RESULTS: Whereas ceiling effects were observed in the overall study population and the 'healthy' subgroup, such was not the case in the geriatric condition subgroups. The majority of hypotheses regarding correlations between survey items and sociodemographic associations were supported. EQ-5D summary scores were lower in respondents who were older, female, widowed/single, lower educated, and living alone. Increasing co-morbidity had a clear negative effect on EQ-5D scores. CONCLUSION: This study supported the construct validity of the EQ-5D across four major geriatric conditions. For older persons who are generally healthy, i.e. reporting few to no chronic conditions, the EQ-5D confers poor discriminative ability due to ceiling effects. Although the overall dataset initially suggested poor discriminative ability for the EQ-5D, such was not the case within subgroups presenting with major geriatric conditions.

Published
2017

23. Examining the construct and known-group validity of a composite endpoint for the Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A largescale data sharing initiative

Author

Hofman, Cynthia S., Lutomski, Jennifer E., Boter, Han, Buurman, Bianca M., De Craen, Anton J M, Donders, A Rogier T, Rikkert, Marcel G M Olde, Makai, Peter, Melis, René J.F., Bleijenberg, N., Blom, J. W., Kempen, G. I J M, Krabbe, P. F M, Moll van Charante, E.P., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van der Horst, H.E., Olde Rikkert, Marcel G M, de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., Van Den Brink, D., Qin, L., TOPICS-MDS research consortium, Steering Committee, Working group, Hofman, Cynthia S., Lutomski, Jennifer E., Boter, Han, Buurman, Bianca M., De Craen, Anton J M, Donders, A Rogier T, Rikkert, Marcel G M Olde, Makai, Peter, Melis, René J.F., Bleijenberg, N., Blom, J. W., Kempen, G. I J M, Krabbe, P. F M, Moll van Charante, E.P., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van der Horst, H.E., Olde Rikkert, Marcel G M, de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., Van Den Brink, D., Qin, L., and TOPICS-MDS research consortium, Steering Committee, Working group

Published
2017

24. Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS

Author

Lutomski, J.E. (Jennifer E.), Krabbe, P.F.M. (Paul), Bleijenberg, N. (Nienke), Blom, J. (Jeanett), Kempen, G.I.J.M. (Gertrudis), MacNeil-Vroomen, J. (Janet), Muntinga, M.E. (Maaike E.), Steyerburg, E. (Ewout), Olde-Rikkert, M.G.M. (Marcel), Melis, R.J.F. (René), Blom, J.W. (Jeanet), Melis, R.J.F., Steyerberg, E.W. (Ewout), Gussekloo, J. (Jacobijn), Olde-Rikkert, M.G.M., van den Brink, D. (Danielle), Lutomski, J.E. (Jennifer), Qin, L. (Li), Kempen, G.I.J.M. (Gertrudis I.J.M.), Krabbe, P.F.M. (Paul F. M.), Buurman, B.M. (Bianca), Horst, H.E. (Henriette) van der, Rooij, S.E.J.A. (Sophia) de, Schols, J.M.G.A. (Jos), Schuurmans, M.J. (Marieke ), Smilde, D.A., Lutomski, J.E. (Jennifer E.), Krabbe, P.F.M. (Paul), Bleijenberg, N. (Nienke), Blom, J. (Jeanett), Kempen, G.I.J.M. (Gertrudis), MacNeil-Vroomen, J. (Janet), Muntinga, M.E. (Maaike E.), Steyerburg, E. (Ewout), Olde-Rikkert, M.G.M. (Marcel), Melis, R.J.F. (René), Blom, J.W. (Jeanet), Melis, R.J.F., Steyerberg, E.W. (Ewout), Gussekloo, J. (Jacobijn), Olde-Rikkert, M.G.M., van den Brink, D. (Danielle), Lutomski, J.E. (Jennifer), Qin, L. (Li), Kempen, G.I.J.M. (Gertrudis I.J.M.), Krabbe, P.F.M. (Paul F. M.), Buurman, B.M. (Bianca), Horst, H.E. (Henriette) van der, Rooij, S.E.J.A. (Sophia) de, Schols, J.M.G.A. (Jos), Schuurmans, M.J. (Marieke ), and Smilde, D.A.

Abstract

Background: As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D (a common HRQoL instrument) across four major chronic

Published
2017
Full Text
View/download PDF

26. Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS

Author

Lutomski, J.E. (Jennifer E.), Krabbe, P.F.M. (Paul), Bleijenberg, N. (Nienke), Blom, J. (Jeanett), Kempen, G.I.J.M. (Gertrudis), MacNeil-Vroomen, J. (Janet), Muntinga, M.E. (Maaike E.), Steyerburg, E. (Ewout), Olde-Rikkert, M.G.M. (Marcel), Melis, R.J.F. (René), Blom, J.W. (Jeanet), Melis, R.J.F., Steyerberg, E.W. (Ewout), Gussekloo, J. (Jacobijn), Olde-Rikkert, M.G.M., van den Brink, D. (Danielle), Lutomski, J.E. (Jennifer), Qin, L. (Li), Kempen, G.I.J.M. (Gertrudis I.J.M.), Krabbe, P.F.M. (Paul F. M.), Buurman, B.M. (Bianca), Horst, H.E. (Henriette) van der, Rooij, S.E.J.A. (Sophia) de, Schols, J.M.G.A. (Jos), Schuurmans, M.J. (Marieke ), Smilde, D.A., Lutomski, J.E. (Jennifer E.), Krabbe, P.F.M. (Paul), Bleijenberg, N. (Nienke), Blom, J. (Jeanett), Kempen, G.I.J.M. (Gertrudis), MacNeil-Vroomen, J. (Janet), Muntinga, M.E. (Maaike E.), Steyerburg, E. (Ewout), Olde-Rikkert, M.G.M. (Marcel), Melis, R.J.F. (René), Blom, J.W. (Jeanet), Melis, R.J.F., Steyerberg, E.W. (Ewout), Gussekloo, J. (Jacobijn), Olde-Rikkert, M.G.M., van den Brink, D. (Danielle), Lutomski, J.E. (Jennifer), Qin, L. (Li), Kempen, G.I.J.M. (Gertrudis I.J.M.), Krabbe, P.F.M. (Paul F. M.), Buurman, B.M. (Bianca), Horst, H.E. (Henriette) van der, Rooij, S.E.J.A. (Sophia) de, Schols, J.M.G.A. (Jos), Schuurmans, M.J. (Marieke ), and Smilde, D.A.

Abstract

Background: As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D (a common HRQoL instrument) across four major chronic

Published
2017
Full Text
View/download PDF

27. Effectiveness and cost-effectiveness of proactive and multidisciplinary integrated care for older people with complex problems in general practice. An Individual Participant Data meta-analysis

Author

Blom, J, van Den Hout, W, Den Elzen, W, Drewes, Y, Bleijenberg, N, Fabbricotti, I, Jansen, D, Kempen, R, Koopmans, R, Looman, W, Melis, R, Metzelthin, S, Moll van Charante, E, Muntinga, M, Numans, M, Ruikes, F, Spoorenberg, S, Stijnen, T, Suijker, J, de Wit, N, Wynia, K, Wind, A, Gussekloo, J, Blom, J, van Den Hout, W, Den Elzen, W, Drewes, Y, Bleijenberg, N, Fabbricotti, I, Jansen, D, Kempen, R, Koopmans, R, Looman, W, Melis, R, Metzelthin, S, Moll van Charante, E, Muntinga, M, Numans, M, Ruikes, F, Spoorenberg, S, Stijnen, T, Suijker, J, de Wit, N, Wynia, K, Wind, A, and Gussekloo, J

Published
2017

28. Examining the construct and known-group validity of a composite endpoint for the Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A largescale data sharing initiative

Author

Hofman, Cynthia S., Lutomski, Jennifer E., Boter, Han, Buurman, Bianca M., De Craen, Anton J M, Donders, A Rogier T, Rikkert, Marcel G M Olde, Makai, Peter, Melis, René J.F., Bleijenberg, N., Blom, J. W., Kempen, G. I J M, Krabbe, P. F M, Moll van Charante, E.P., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van der Horst, H.E., Olde Rikkert, Marcel G M, de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., Van Den Brink, D., Qin, L., TOPICS-MDS research consortium, Steering Committee, Working group, Hofman, Cynthia S., Lutomski, Jennifer E., Boter, Han, Buurman, Bianca M., De Craen, Anton J M, Donders, A Rogier T, Rikkert, Marcel G M Olde, Makai, Peter, Melis, René J.F., Bleijenberg, N., Blom, J. W., Kempen, G. I J M, Krabbe, P. F M, Moll van Charante, E.P., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van der Horst, H.E., Olde Rikkert, Marcel G M, de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., Van Den Brink, D., Qin, L., and TOPICS-MDS research consortium, Steering Committee, Working group

Published
2017

29. Benefits and Factors Influencing the Design of Intergenerational Digital Games: A Systematic Literature Review

Author

Organisation Studies, LS Mediatheorie, Social Urban Transitions, UU LEG Research USG Public Matters Organization and Management, UU LEG Research USG Public Matters, de la Hera Conde-Pumpido, T., Loos, E.F., Simons, M., Blom, J., Organisation Studies, LS Mediatheorie, Social Urban Transitions, UU LEG Research USG Public Matters Organization and Management, UU LEG Research USG Public Matters, de la Hera Conde-Pumpido, T., Loos, E.F., Simons, M., and Blom, J.

Published
2017

30. From Tools to “Recipes”: Building a Media Suite within the Dutch Digital Humanities Infrastructure CLARIAH

Author

LS OW Ned.tv-cultuur intern.context, ICON - Media and Performance Studies, Martinez-Ortiz, Carlos, Ordelman, Roeland, Koolen, Marijn, Noordegraaf, J.J., Melgar, Liliana, Aroyo, Lora, Blom, J., van Gorp, J., Baaren, E., Beelen, K.J., Kiewik, R., Poell, T., LS OW Ned.tv-cultuur intern.context, ICON - Media and Performance Studies, Martinez-Ortiz, Carlos, Ordelman, Roeland, Koolen, Marijn, Noordegraaf, J.J., Melgar, Liliana, Aroyo, Lora, Blom, J., van Gorp, J., Baaren, E., Beelen, K.J., Kiewik, R., and Poell, T.

Published
2017

31. Comparative genomics of Erwinia amylovora isolates from Mexico

Author

Smits, Theo H.M., Guerrero-Prieto, V. M., Hernandez-Escarcega, G., Rezzonico, Fabio, Blom, J., Goesmann, A., Duffy, Brion, Stockwell, V. O., Smits, Theo H.M., Guerrero-Prieto, V. M., Hernandez-Escarcega, G., Rezzonico, Fabio, Blom, J., Goesmann, A., Duffy, Brion, and Stockwell, V. O.

Abstract

Isolates of Erwinia amylovora from Mexico were collected and tested for their resistance to antibiotics used in orchards. Isolates with resistance to streptomycin were found, but no resistance to the commonly used antibiotics tetracycline and gentamicin was detected. The genomes of three isolates were sequenced and compared to reference genomes. The streptomycin resistance of two isolates was due to the common K43R mutation in rpsL. Analysis of the genomes revealed that the strains belong to CRISPR group I, which is common with strains from the Northeastern region of the USA and that each strain has a mutation in avrRpt2, which is present in strains that are able to overcome the resistance of Malus × robusta 5.

Published
2017

32. Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS

Author

Lutomski, J.E., Krabbe, P.F.M., Bleijenberg, N., Blom, J., Kempen, G.I., MacNeil-Vroomen, J., Muntinga, M.E., Steyerburg, E., Olde-Rikkert, M.G.M., Melis, R.J.F., Lutomski, J.E., Krabbe, P.F.M., Bleijenberg, N., Blom, J., Kempen, G.I., MacNeil-Vroomen, J., Muntinga, M.E., Steyerburg, E., Olde-Rikkert, M.G.M., and Melis, R.J.F.

Abstract

Contains fulltext : 169741.pdf (publisher's version ) (Open Access), BACKGROUND: As populations age, chronic geriatric conditions linked to progressive organ failure jeopardize health-related quality of life (HRQoL). Thus, this research assessed the validity and applicability of the EQ-5D (a common HRQoL instrument) across four major chronic geriatric conditions: hearing issues, joint damage, urinary incontinence, or dizziness with falls. METHODS: The study sample comprised 25,637 community-dwelling persons aged 65 years and older residing in the Netherlands (Data source: TOPICS-MDS, www.topics-mds.eu ). Floor and ceiling effects were examined. To assess convergent validity, random effects meta-correlations (Spearman's rho) were derived between individual EQ-5D domains and related survey items. To further examine construct validity, the association between sociodemographic characteristics and EQ-5D summary scores were assessed using linear mixed models. Outcomes were compared to the overall study population as well as a 'healthy' subgroup reporting no major chronic conditions. RESULTS: Whereas ceiling effects were observed in the overall study population and the 'healthy' subgroup, such was not the case in the geriatric condition subgroups. The majority of hypotheses regarding correlations between survey items and sociodemographic associations were supported. EQ-5D summary scores were lower in respondents who were older, female, widowed/single, lower educated, and living alone. Increasing co-morbidity had a clear negative effect on EQ-5D scores. CONCLUSION: This study supported the construct validity of the EQ-5D across four major geriatric conditions. For older persons who are generally healthy, i.e. reporting few to no chronic conditions, the EQ-5D confers poor discriminative ability due to ceiling effects. Although the overall dataset initially suggested poor discriminative ability for the EQ-5D, such was not the case within subgroups presenting with major geriatric conditions.

Published
2017

33. Measurement properties of the EQ-5D across four major geriatric conditions : Findings from TOPICS-MDS

Author

Lutomski, Jennifer E., Krabbe, Paul F M, Bleijenberg, N., Blom, Jeanett, Kempen, Gertrudis I J M, MacNeil-Vroomen, Janet, Muntinga, Maaike E., Steyerburg, Ewout, Olde Rikkert, Marcel G M, Melis, René J.F., Blom, J. W., Melis, R.J.F., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van den Brink, D., Lutomski, J.E., Qin, L., Kempen, G. I.J.M., Krabbe, P. F M, Buurman, B.M., van der Horst, H.E., de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., TOPICS Consortium, Lutomski, Jennifer E., Krabbe, Paul F M, Bleijenberg, N., Blom, Jeanett, Kempen, Gertrudis I J M, MacNeil-Vroomen, Janet, Muntinga, Maaike E., Steyerburg, Ewout, Olde Rikkert, Marcel G M, Melis, René J.F., Blom, J. W., Melis, R.J.F., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van den Brink, D., Lutomski, J.E., Qin, L., Kempen, G. I.J.M., Krabbe, P. F M, Buurman, B.M., van der Horst, H.E., de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., and TOPICS Consortium

Published
2017

34. Examining the construct and known-group validity of a composite endpoint for the Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A largescale data sharing initiative

Author

Hofman, Cynthia S., Lutomski, Jennifer E., Boter, Han, Buurman, Bianca M., De Craen, Anton J M, Donders, A Rogier T, Rikkert, Marcel G M Olde, Makai, Peter, Melis, René J.F., Bleijenberg, N., Blom, J. W., Kempen, G. I J M, Krabbe, P. F M, Moll van Charante, E.P., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van der Horst, H.E., Olde Rikkert, Marcel G M, de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., Van Den Brink, D., Qin, L., TOPICS-MDS research consortium, Steering Committee, Working group, Hofman, Cynthia S., Lutomski, Jennifer E., Boter, Han, Buurman, Bianca M., De Craen, Anton J M, Donders, A Rogier T, Rikkert, Marcel G M Olde, Makai, Peter, Melis, René J.F., Bleijenberg, N., Blom, J. W., Kempen, G. I J M, Krabbe, P. F M, Moll van Charante, E.P., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van der Horst, H.E., Olde Rikkert, Marcel G M, de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., Van Den Brink, D., Qin, L., and TOPICS-MDS research consortium, Steering Committee, Working group

Published
2017

35. From Tools to “Recipes”: Building a Media Suite within the Dutch Digital Humanities Infrastructure CLARIAH

Author

LS OW Ned.tv-cultuur intern.context, ICON - Media and Performance Studies, Afd Media, Data & Citizenship, Martinez-Ortiz, Carlos, Ordelman, Roeland, Koolen, Marijn, Noordegraaf, J.J., Melgar, Liliana, Aroyo, Lora, Blom, J., van Gorp, J., Baaren, E., Beelen, K.J., Kiewik, R., Poell, T., LS OW Ned.tv-cultuur intern.context, ICON - Media and Performance Studies, Afd Media, Data & Citizenship, Martinez-Ortiz, Carlos, Ordelman, Roeland, Koolen, Marijn, Noordegraaf, J.J., Melgar, Liliana, Aroyo, Lora, Blom, J., van Gorp, J., Baaren, E., Beelen, K.J., Kiewik, R., and Poell, T.

Published
2017

36. Benefits and Factors Influencing the Design of Intergenerational Digital Games: A Systematic Literature Review

Author

Organisation Studies, LS Mediatheorie, Social Urban Transitions, UU LEG Research USG Public Matters Organization and Management, UU LEG Research USG Public Matters, de la Hera Conde-Pumpido, T., Loos, E.F., Simons, M., Blom, J., Organisation Studies, LS Mediatheorie, Social Urban Transitions, UU LEG Research USG Public Matters Organization and Management, UU LEG Research USG Public Matters, de la Hera Conde-Pumpido, T., Loos, E.F., Simons, M., and Blom, J.

Published
2017

38. Effectiveness and cost-effectiveness of proactive and multidisciplinary integrated care for older people with complex problems in general practice. An Individual Participant Data meta-analysis

Author

Blom, J, van Den Hout, W, Den Elzen, W, Drewes, Y, Bleijenberg, N, Fabbricotti, I, Jansen, D, Kempen, R, Koopmans, R, Looman, W, Melis, R, Metzelthin, S, Moll van Charante, E, Muntinga, M, Numans, M, Ruikes, F, Spoorenberg, S, Stijnen, T, Suijker, J, de Wit, N, Wynia, K, Wind, A, Gussekloo, J, Blom, J, van Den Hout, W, Den Elzen, W, Drewes, Y, Bleijenberg, N, Fabbricotti, I, Jansen, D, Kempen, R, Koopmans, R, Looman, W, Melis, R, Metzelthin, S, Moll van Charante, E, Muntinga, M, Numans, M, Ruikes, F, Spoorenberg, S, Stijnen, T, Suijker, J, de Wit, N, Wynia, K, Wind, A, and Gussekloo, J

Published
2017

41. Measurement properties of the EQ-5D across four major geriatric conditions: Findings from TOPICS-MDS

Author

UMC Utrecht, Verplegingswetenschap, Infection & Immunity, Pathologie, Unit Opleiding Aios, Healthcare Innovation & Evaluation, Circulatory Health, JC onderzoeksprogramma Methodologie, Lutomski, Jennifer E., Krabbe, Paul F M, Bleijenberg, N., Blom, Jeanett, Kempen, Gertrudis I J M, MacNeil-Vroomen, Janet, Muntinga, Maaike E., Steyerburg, Ewout, Olde Rikkert, Marcel G M, Melis, René J.F., Blom, J. W., Melis, R.J.F., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van den Brink, D., Lutomski, J.E., Qin, L., Kempen, G. I.J.M., Krabbe, P. F M, Buurman, B.M., van der Horst, H.E., de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., TOPICS Consortium, UMC Utrecht, Verplegingswetenschap, Infection & Immunity, Pathologie, Unit Opleiding Aios, Healthcare Innovation & Evaluation, Circulatory Health, JC onderzoeksprogramma Methodologie, Lutomski, Jennifer E., Krabbe, Paul F M, Bleijenberg, N., Blom, Jeanett, Kempen, Gertrudis I J M, MacNeil-Vroomen, Janet, Muntinga, Maaike E., Steyerburg, Ewout, Olde Rikkert, Marcel G M, Melis, René J.F., Blom, J. W., Melis, R.J.F., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van den Brink, D., Lutomski, J.E., Qin, L., Kempen, G. I.J.M., Krabbe, P. F M, Buurman, B.M., van der Horst, H.E., de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., and TOPICS Consortium

Published
2017

42. Examining the construct and known-group validity of a composite endpoint for the Older Persons and Informal Caregivers Survey Minimum Data Set (TOPICS-MDS); A largescale data sharing initiative

Author

UMC Utrecht, Verplegingswetenschap, Infection & Immunity, Healthcare Innovation & Evaluation, Circulatory Health, JC onderzoeksprogramma Methodologie, Hofman, Cynthia S., Lutomski, Jennifer E., Boter, Han, Buurman, Bianca M., De Craen, Anton J M, Donders, A Rogier T, Rikkert, Marcel G M Olde, Makai, Peter, Melis, René J.F., Bleijenberg, N., Blom, J. W., Kempen, G. I J M, Krabbe, P. F M, Moll van Charante, E.P., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van der Horst, H.E., Olde Rikkert, Marcel G M, de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., Van Den Brink, D., Qin, L., TOPICS-MDS research consortium, Steering Committee, Working group, UMC Utrecht, Verplegingswetenschap, Infection & Immunity, Healthcare Innovation & Evaluation, Circulatory Health, JC onderzoeksprogramma Methodologie, Hofman, Cynthia S., Lutomski, Jennifer E., Boter, Han, Buurman, Bianca M., De Craen, Anton J M, Donders, A Rogier T, Rikkert, Marcel G M Olde, Makai, Peter, Melis, René J.F., Bleijenberg, N., Blom, J. W., Kempen, G. I J M, Krabbe, P. F M, Moll van Charante, E.P., Muntinga, M. E., Steyerberg, Ewout W., Gussekloo, J., van der Horst, H.E., Olde Rikkert, Marcel G M, de Rooij, S.E.J.A., Schols, Jos M. G. A., Schuurmans, M. J., Smilde, D. A., Van Den Brink, D., Qin, L., and TOPICS-MDS research consortium, Steering Committee, Working group

Published
2017

43. From Tools to “Recipes”: Building a Media Suite within the Dutch Digital Humanities Infrastructure CLARIAH

Author

LS OW Ned.tv-cultuur intern.context, ICON - Media and Performance Studies, Afd Media, Data & Citizenship, Martinez-Ortiz, Carlos, Ordelman, Roeland, Koolen, Marijn, Noordegraaf, J.J., Melgar, Liliana, Aroyo, Lora, Blom, J., van Gorp, J., Baaren, E., Beelen, K.J., Kiewik, R., Poell, T., LS OW Ned.tv-cultuur intern.context, ICON - Media and Performance Studies, Afd Media, Data & Citizenship, Martinez-Ortiz, Carlos, Ordelman, Roeland, Koolen, Marijn, Noordegraaf, J.J., Melgar, Liliana, Aroyo, Lora, Blom, J., van Gorp, J., Baaren, E., Beelen, K.J., Kiewik, R., and Poell, T.

Published
2017

44. Benefits and Factors Influencing the Design of Intergenerational Digital Games: A Systematic Literature Review

Author

Organisation Studies, LS Mediatheorie, Social Urban Transitions, UU LEG Research USG Public Matters Organization and Management, UU LEG Research USG Public Matters, de la Hera Conde-Pumpido, T., Loos, E.F., Simons, M., Blom, J., Organisation Studies, LS Mediatheorie, Social Urban Transitions, UU LEG Research USG Public Matters Organization and Management, UU LEG Research USG Public Matters, de la Hera Conde-Pumpido, T., Loos, E.F., Simons, M., and Blom, J.

Published
2017

45. Comparative genomics of Erwinia amylovora isolates from Mexico

Author

Smits, Theo H.M., Guerrero-Prieto, V. M., Hernandez-Escarcega, G., Rezzonico, Fabio, Blom, J., Goesmann, A., Duffy, Brion, Stockwell, V. O., Smits, Theo H.M., Guerrero-Prieto, V. M., Hernandez-Escarcega, G., Rezzonico, Fabio, Blom, J., Goesmann, A., Duffy, Brion, and Stockwell, V. O.

Abstract

Isolates of Erwinia amylovora from Mexico were collected and tested for their resistance to antibiotics used in orchards. Isolates with resistance to streptomycin were found, but no resistance to the commonly used antibiotics tetracycline and gentamicin was detected. The genomes of three isolates were sequenced and compared to reference genomes. The streptomycin resistance of two isolates was due to the common K43R mutation in rpsL. Analysis of the genomes revealed that the strains belong to CRISPR group I, which is common with strains from the Northeastern region of the USA and that each strain has a mutation in avrRpt2, which is present in strains that are able to overcome the resistance of Malus × robusta 5.

Published
2017

48. Flood Proof Myanmar

Author

Blom, J. (author), Caminada, I. (author), Colina Alonso, A. (author), Nientker, G. (author), Rijper, H. (author), Stoop, N. (author), Blom, J. (author), Caminada, I. (author), Colina Alonso, A. (author), Nientker, G. (author), Rijper, H. (author), and Stoop, N. (author)

Abstract

The objective of this research is to make a general framework, that when run through one can find a suitable measure to make a particular area in Myanmar flood proof. Myanmar suffers from yearly floods that have a huge impact on the population. Making an area flood proof is therefore one of the objectives of the civilian government. In this report ‘flood proof’ is defined as a status that shows that an area is prepared to control the effects of a flood. To achieve this goal a general framework has been created. This general framework guides the reader through multiple analyses, a development of alternatives, an assessment and an implementation. It has the objective to be transparent, reproducible, elementary, based on existing methods and based on data. To test this general framework on these criteria two cases with different research areas are chosen namely, case I: Nyaungdon and case II: Dala. The report is therefore developed as an incremental and iterative process. In this report a range of alternatives has been taken into account, that includes more than only the hydraulic measures. To implement the Dutch method of treating a (potential) flood a multi-layer safety approach has been used. This approach consist of three layers namely, prevention, spatial solutions and crisis management. All the alternatives of this report can be classified into one of these layers. The analysis phase of the general framework has been focussed on four specific analyses. The four specific analyses are a flood risk analysis, an actor analysis, an evacuation analysis, and a future scenario analysis. These analyses combined with the general analyses lead to the development of alternatives. The method that has been used to determine the relatively best alternative is the multi-criteria analysis. Most of the time it is preferred to combine several alternatives in packages to generate the best possible solutions. After these solution packages have been created for every research area an, Civil Engineering and Geosciences, Hydraulic Engineering, Transport, Infrastructure & Logistics, Multidisciplinary Project CIE4061-09

Published
2016

Catalog

Books, media, physical & digital resources
See catalog results