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1. Public involvement in health research:What does 'good' look like in practice?

Author

Liabo, K., Boddy, K., Bortoli, S., Irvine, J., Boult, H., Fredlund, M., Joseph, N., Bjornstad, G., Morris, C., Liabo, K., Boddy, K., Bortoli, S., Irvine, J., Boult, H., Fredlund, M., Joseph, N., Bjornstad, G., and Morris, C.

Abstract

Plain English summary: Background Patient and public involvement means researchers working with members of the public, patients or carers to jointly plan and carry out research. Aim This article is written by members of three involvement groups, and the university employees that they work with. We wanted to jointly reflect on what enables our collaborative work, and what the challenges are for everyone involved. What we did and how we did it We wanted to establish what the literature defines as 'good' public involvement and compare this with processes and practices in our involvement groups. We therefore carried out a literature review and each group met separately to discuss what characterises good involvement, and what the challenges are. From these discussions we developed a set of descriptions about each group. We compared the literature review findings with what came out of the discussions within the involvement groups. Findings Some of the involvement principles from the literature were similar to the priorities of the involvement groups. In addition, the groups identified characteristics of 'good' involvement practice that were not reported in the literature: passion and enthusiasm, informal and welcoming meeting spaces, and opportunities to share lived experiences. In this article we present examples of how principles for good involvement are practiced in these groups, and difficulties we have experienced. Abstract: Background Patient and public involvement is important for producing relevant and accessible health research. Evidence of impact from involvement is growing, but there is also a need for research on how to create conditions for meaningful collaborations between researchers and public advisers. Objective We report on a co-produced self-reflective evaluation of involvement practices in three UK research programmes. Methods A structured review identified research-based principles for 'good' public involvement in research. In parallel, members of thr

Published
2020

2. Milky Way Satellite Census. III. Constraints on Dark Matter Properties from Observations of Milky Way Satellite Galaxies

Author

Nadler, E. O., Drlica-Wagner, A., Bechtol, K., Mau, S., Wechsler, R. H., Gluscevic, V., Boddy, K., Pace, A. B., Li, T. S., McNanna, M., Riley, A. H., García-Bellido, J., Mao, Y. -Y., Green, G., Burke, D. L., Peter, A., Jain, B., Abbott, T. M. C., Aguena, M., Allam, S., Annis, J., Avila, S., Brooks, D., Kind, M. Carrasco, Carretero, J., Costanzi, M., da Costa, L. N., De Vicente, J., Desai, S., Diehl, H. T., Doel, P., Everett, S., Evrard, A. E., Flaugher, B., Frieman, J., Gerdes, D. W., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hinton, S. R., Honscheid, K., Huterer, D., James, D. J., Krause, E., Kuehn, K., Kuropatkin, N., Lahav, O., Maia, M. A. G., Marshall, J. L., Menanteau, F., Miquel, R., Palmese, A., Paz-Chinchón, F., Plazas, A. A., Romer, A. K., Sanchez, E., Scarpine, V., Serrano, S., Sevilla-Noarbe, I., Smith, M., Soares-Santos, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Tucker, D. L., Walker, A. R., Wester, W., Nadler, E. O., Drlica-Wagner, A., Bechtol, K., Mau, S., Wechsler, R. H., Gluscevic, V., Boddy, K., Pace, A. B., Li, T. S., McNanna, M., Riley, A. H., García-Bellido, J., Mao, Y. -Y., Green, G., Burke, D. L., Peter, A., Jain, B., Abbott, T. M. C., Aguena, M., Allam, S., Annis, J., Avila, S., Brooks, D., Kind, M. Carrasco, Carretero, J., Costanzi, M., da Costa, L. N., De Vicente, J., Desai, S., Diehl, H. T., Doel, P., Everett, S., Evrard, A. E., Flaugher, B., Frieman, J., Gerdes, D. W., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hinton, S. R., Honscheid, K., Huterer, D., James, D. J., Krause, E., Kuehn, K., Kuropatkin, N., Lahav, O., Maia, M. A. G., Marshall, J. L., Menanteau, F., Miquel, R., Palmese, A., Paz-Chinchón, F., Plazas, A. A., Romer, A. K., Sanchez, E., Scarpine, V., Serrano, S., Sevilla-Noarbe, I., Smith, M., Soares-Santos, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Tucker, D. L., Walker, A. R., and Wester, W.

Abstract

We perform a comprehensive study of Milky Way (MW) satellite galaxies to constrain the fundamental properties of dark matter (DM). This analysis fully incorporates inhomogeneities in the spatial distribution and detectability of MW satellites and marginalizes over uncertainties in the mapping between galaxies and DM halos, the properties of the MW system, and the disruption of subhalos by the MW disk. Our results are consistent with the cold, collisionless DM paradigm and yield the strongest cosmological constraints to date on particle models of warm, interacting, and fuzzy dark matter. At $95\%$ confidence, we report limits on (i) the mass of thermal relic warm DM, $m_{\rm WDM} > 6.5\ \mathrm{keV}$ (free-streaming length, $\lambda_{\rm{fs}} \lesssim 10\,h^{-1}\ \mathrm{kpc}$), (ii) the velocity-independent DM-proton scattering cross section, $\sigma_{0} < 8.8\times 10^{-29}\ \mathrm{cm}^{2}$ for a $100\ \mathrm{MeV}$ DM particle mass (DM-proton coupling, $c_p \lesssim (0.3\ \mathrm{GeV})^{-2}$), and (iii) the mass of fuzzy DM, $m_{\phi}> 2.9 \times 10^{-21}\ \mathrm{eV}$ (de Broglie wavelength, $\lambda_{\rm{dB}} \lesssim 0.5\ \mathrm{kpc}$). These constraints are complementary to other observational and laboratory constraints on DM properties., Comment: 15 pages, 5 figures, 2 tables. Updated to published version

Published
2020
Full Text
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3. Public involvement in health research : What does 'good' look like in practice?

Author

Liabo, K., Boddy, K., Bortoli, S., Irvine, J., Boult, H., Fredlund, M., Joseph, N., Bjornstad, G., Morris, C., Liabo, K., Boddy, K., Bortoli, S., Irvine, J., Boult, H., Fredlund, M., Joseph, N., Bjornstad, G., and Morris, C.

Abstract

Plain English summary: Background Patient and public involvement means researchers working with members of the public, patients or carers to jointly plan and carry out research. Aim This article is written by members of three involvement groups, and the university employees that they work with. We wanted to jointly reflect on what enables our collaborative work, and what the challenges are for everyone involved. What we did and how we did it We wanted to establish what the literature defines as 'good' public involvement and compare this with processes and practices in our involvement groups. We therefore carried out a literature review and each group met separately to discuss what characterises good involvement, and what the challenges are. From these discussions we developed a set of descriptions about each group. We compared the literature review findings with what came out of the discussions within the involvement groups. Findings Some of the involvement principles from the literature were similar to the priorities of the involvement groups. In addition, the groups identified characteristics of 'good' involvement practice that were not reported in the literature: passion and enthusiasm, informal and welcoming meeting spaces, and opportunities to share lived experiences. In this article we present examples of how principles for good involvement are practiced in these groups, and difficulties we have experienced. Abstract: Background Patient and public involvement is important for producing relevant and accessible health research. Evidence of impact from involvement is growing, but there is also a need for research on how to create conditions for meaningful collaborations between researchers and public advisers. Objective We report on a co-produced self-reflective evaluation of involvement practices in three UK research programmes. Methods A structured review identified research-based principles for 'good' public involvement in research. In parallel, members of thr

Published
2020

4. Milky Way Satellite Census. III. Constraints on Dark Matter Properties from Observations of Milky Way Satellite Galaxies

Author

Nadler, E. O., Drlica-Wagner, A., Bechtol, K., Mau, S., Wechsler, R. H., Gluscevic, V., Boddy, K., Pace, A. B., Li, T. S., McNanna, M., Riley, A. H., García-Bellido, J., Mao, Y. -Y., Green, G., Burke, D. L., Peter, A., Jain, B., Abbott, T. M. C., Aguena, M., Allam, S., Annis, J., Avila, S., Brooks, D., Kind, M. Carrasco, Carretero, J., Costanzi, M., da Costa, L. N., De Vicente, J., Desai, S., Diehl, H. T., Doel, P., Everett, S., Evrard, A. E., Flaugher, B., Frieman, J., Gerdes, D. W., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hinton, S. R., Honscheid, K., Huterer, D., James, D. J., Krause, E., Kuehn, K., Kuropatkin, N., Lahav, O., Maia, M. A. G., Marshall, J. L., Menanteau, F., Miquel, R., Palmese, A., Paz-Chinchón, F., Plazas, A. A., Romer, A. K., Sanchez, E., Scarpine, V., Serrano, S., Sevilla-Noarbe, I., Smith, M., Soares-Santos, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Tucker, D. L., Walker, A. R., Wester, W., Nadler, E. O., Drlica-Wagner, A., Bechtol, K., Mau, S., Wechsler, R. H., Gluscevic, V., Boddy, K., Pace, A. B., Li, T. S., McNanna, M., Riley, A. H., García-Bellido, J., Mao, Y. -Y., Green, G., Burke, D. L., Peter, A., Jain, B., Abbott, T. M. C., Aguena, M., Allam, S., Annis, J., Avila, S., Brooks, D., Kind, M. Carrasco, Carretero, J., Costanzi, M., da Costa, L. N., De Vicente, J., Desai, S., Diehl, H. T., Doel, P., Everett, S., Evrard, A. E., Flaugher, B., Frieman, J., Gerdes, D. W., Gruen, D., Gruendl, R. A., Gschwend, J., Gutierrez, G., Hinton, S. R., Honscheid, K., Huterer, D., James, D. J., Krause, E., Kuehn, K., Kuropatkin, N., Lahav, O., Maia, M. A. G., Marshall, J. L., Menanteau, F., Miquel, R., Palmese, A., Paz-Chinchón, F., Plazas, A. A., Romer, A. K., Sanchez, E., Scarpine, V., Serrano, S., Sevilla-Noarbe, I., Smith, M., Soares-Santos, M., Suchyta, E., Swanson, M. E. C., Tarle, G., Tucker, D. L., Walker, A. R., and Wester, W.

Abstract

We perform a comprehensive study of Milky Way (MW) satellite galaxies to constrain the fundamental properties of dark matter (DM). This analysis fully incorporates inhomogeneities in the spatial distribution and detectability of MW satellites and marginalizes over uncertainties in the mapping between galaxies and DM halos, the properties of the MW system, and the disruption of subhalos by the MW disk. Our results are consistent with the cold, collisionless DM paradigm and yield the strongest cosmological constraints to date on particle models of warm, interacting, and fuzzy dark matter. At $95\%$ confidence, we report limits on (i) the mass of thermal relic warm DM, $m_{\rm WDM} > 6.5\ \mathrm{keV}$ (free-streaming length, $\lambda_{\rm{fs}} \lesssim 10\,h^{-1}\ \mathrm{kpc}$), (ii) the velocity-independent DM-proton scattering cross section, $\sigma_{0} < 8.8\times 10^{-29}\ \mathrm{cm}^{2}$ for a $100\ \mathrm{MeV}$ DM particle mass (DM-proton coupling, $c_p \lesssim (0.3\ \mathrm{GeV})^{-2}$), and (iii) the mass of fuzzy DM, $m_{\phi}> 2.9 \times 10^{-21}\ \mathrm{eV}$ (de Broglie wavelength, $\lambda_{\rm{dB}} \lesssim 0.5\ \mathrm{kpc}$). These constraints are complementary to other observational and laboratory constraints on DM properties., Comment: 15 pages, 5 figures, 2 tables. Updated to published version

Published
2020
Full Text
View/download PDF

5. PICO: Probe of Inflation and Cosmic Origins

Author

Hanany, S., Alvarez, M., Artis, E., Ashton, P., Aumont, J., Aurlien, R., Banerji, R., Barreiro, R. B., Bartlett, J. G., Basak, S., Battaglia, N., Bock, J., Boddy, K. K., Bonato, M., Borrill, J., Bouchet, F., Boulanger, F., Burkhart, B., Chluba, J., Chuss, D., Clark, S., Cooperrider, J., Crill, B. P., De Zotti, G., Delabrouille, J., Di Valentino, E., Didier, J., Dore, O., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Feeney, S., Filippini, J., Fissel, L., Flauger, R., Fuskeland, U., Gluscevic, V., Gorski, K. M., Green, D., Hensley, B., Herranz, D., Hill, J. C., Hivon, E., Hlozek, R., Hubmayr, J., Johnson, B. R., Jones, W., Jones, T., Knox, L., Kogut, A., Lopez-Caniego, M., Lawrence, C., Lazarian, A., Li, Z., Madhavacheril, M., Melin, J. B., Meyers, J., Murray, C., Negrello, M., Novak, G., O'Brient, R., Paine, C., Pearson, T., Pogosian, L., Pryke, C., Puglisi, G., Remazeilles, M., Rocha, G., Schmittfull, M., Scott, D., Shirron, P., Stephens, I., Sutin, B., Tomasi, M., Trangsrud, A., van Engelen, A., Vansyngel, F., Wehus, I. K., Wen, Q., Xu, S., Young, K., Zonca, A., Hanany, S., Alvarez, M., Artis, E., Ashton, P., Aumont, J., Aurlien, R., Banerji, R., Barreiro, R. B., Bartlett, J. G., Basak, S., Battaglia, N., Bock, J., Boddy, K. K., Bonato, M., Borrill, J., Bouchet, F., Boulanger, F., Burkhart, B., Chluba, J., Chuss, D., Clark, S., Cooperrider, J., Crill, B. P., De Zotti, G., Delabrouille, J., Di Valentino, E., Didier, J., Dore, O., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Feeney, S., Filippini, J., Fissel, L., Flauger, R., Fuskeland, U., Gluscevic, V., Gorski, K. M., Green, D., Hensley, B., Herranz, D., Hill, J. C., Hivon, E., Hlozek, R., Hubmayr, J., Johnson, B. R., Jones, W., Jones, T., Knox, L., Kogut, A., Lopez-Caniego, M., Lawrence, C., Lazarian, A., Li, Z., Madhavacheril, M., Melin, J. B., Meyers, J., Murray, C., Negrello, M., Novak, G., O'Brient, R., Paine, C., Pearson, T., Pogosian, L., Pryke, C., Puglisi, G., Remazeilles, M., Rocha, G., Schmittfull, M., Scott, D., Shirron, P., Stephens, I., Sutin, B., Tomasi, M., Trangsrud, A., van Engelen, A., Vansyngel, F., Wehus, I. K., Wen, Q., Xu, S., Young, K., and Zonca, A.

Abstract

The Probe of Inflation and Cosmic Origins (PICO) is a proposed probe-scale space mission consisting of an imaging polarimeter operating in frequency bands between 20 and 800 GHz. We describe the science achievable by PICO, which has sensitivity equivalent to more than 3300 Planck missions, the technical implementation, the schedule and cost., Comment: APC White Paper submitted to the Astro2020 decadal panel; 10 page version of the 50 page mission study report arXiv:1902.10541

Published
2019

6. PICO: Probe of Inflation and Cosmic Origins

Author

Hanany, S., Alvarez, M., Artis, E., Ashton, P., Aumont, J., Aurlien, R., Banerji, R., Barreiro, R. B., Bartlett, J. G., Basak, S., Battaglia, N., Bock, J., Boddy, K. K., Bonato, M., Borrill, J., Bouchet, F., Boulanger, F., Burkhart, B., Chluba, J., Chuss, D., Clark, S., Cooperrider, J., Crill, B. P., De Zotti, G., Delabrouille, J., Di Valentino, E., Didier, J., Dore, O., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Feeney, S., Filippini, J., Fissel, L., Flauger, R., Fuskeland, U., Gluscevic, V., Gorski, K. M., Green, D., Hensley, B., Herranz, D., Hill, J. C., Hivon, E., Hlozek, R., Hubmayr, J., Johnson, B. R., Jones, W., Jones, T., Knox, L., Kogut, A., Lopez-Caniego, M., Lawrence, C., Lazarian, A., Li, Z., Madhavacheril, M., Melin, J. B., Meyers, J., Murray, C., Negrello, M., Novak, G., O'Brient, R., Paine, C., Pearson, T., Pogosian, L., Pryke, C., Puglisi, G., Remazeilles, M., Rocha, G., Schmittfull, M., Scott, D., Shirron, P., Stephens, I., Sutin, B., Tomasi, M., Trangsrud, A., van Engelen, A., Vansyngel, F., Wehus, I. K., Wen, Q., Xu, S., Young, K., Zonca, A., Hanany, S., Alvarez, M., Artis, E., Ashton, P., Aumont, J., Aurlien, R., Banerji, R., Barreiro, R. B., Bartlett, J. G., Basak, S., Battaglia, N., Bock, J., Boddy, K. K., Bonato, M., Borrill, J., Bouchet, F., Boulanger, F., Burkhart, B., Chluba, J., Chuss, D., Clark, S., Cooperrider, J., Crill, B. P., De Zotti, G., Delabrouille, J., Di Valentino, E., Didier, J., Dore, O., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Feeney, S., Filippini, J., Fissel, L., Flauger, R., Fuskeland, U., Gluscevic, V., Gorski, K. M., Green, D., Hensley, B., Herranz, D., Hill, J. C., Hivon, E., Hlozek, R., Hubmayr, J., Johnson, B. R., Jones, W., Jones, T., Knox, L., Kogut, A., Lopez-Caniego, M., Lawrence, C., Lazarian, A., Li, Z., Madhavacheril, M., Melin, J. B., Meyers, J., Murray, C., Negrello, M., Novak, G., O'Brient, R., Paine, C., Pearson, T., Pogosian, L., Pryke, C., Puglisi, G., Remazeilles, M., Rocha, G., Schmittfull, M., Scott, D., Shirron, P., Stephens, I., Sutin, B., Tomasi, M., Trangsrud, A., van Engelen, A., Vansyngel, F., Wehus, I. K., Wen, Q., Xu, S., Young, K., and Zonca, A.

Abstract

The Probe of Inflation and Cosmic Origins (PICO) is a proposed probe-scale space mission consisting of an imaging polarimeter operating in frequency bands between 20 and 800 GHz. We describe the science achievable by PICO, which has sensitivity equivalent to more than 3300 Planck missions, the technical implementation, the schedule and cost., Comment: APC White Paper submitted to the Astro2020 decadal panel; 10 page version of the 50 page mission study report arXiv:1902.10541

Published
2019

7. PICO: Probe of Inflation and Cosmic Origins

Author

Hanany, S., Alvarez, M., Artis, E., Ashton, P., Aumont, J., Aurlien, R., Banerji, R., Barreiro, R. B., Bartlett, J. G., Basak, S., Battaglia, N., Bock, J., Boddy, K. K., Bonato, M., Borrill, J., Bouchet, F., Boulanger, F., Burkhart, B., Chluba, J., Chuss, D., Clark, S., Cooperrider, J., Crill, B. P., De Zotti, G., Delabrouille, J., Di Valentino, E., Didier, J., Dore, O., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Feeney, S., Filippini, J., Fissel, L., Flauger, R., Fuskeland, U., Gluscevic, V., Gorski, K. M., Green, D., Hensley, B., Herranz, D., Hill, J. C., Hivon, E., Hlozek, R., Hubmayr, J., Johnson, B. R., Jones, W., Jones, T., Knox, L., Kogut, A., Lopez-Caniego, M., Lawrence, C., Lazarian, A., Li, Z., Madhavacheril, M., Melin, J. B., Meyers, J., Murray, C., Negrello, M., Novak, G., O'Brient, R., Paine, C., Pearson, T., Pogosian, L., Pryke, C., Puglisi, G., Remazeilles, M., Rocha, G., Schmittfull, M., Scott, D., Shirron, P., Stephens, I., Sutin, B., Tomasi, M., Trangsrud, A., van Engelen, A., Vansyngel, F., Wehus, I. K., Wen, Q., Xu, S., Young, K., Zonca, A., Hanany, S., Alvarez, M., Artis, E., Ashton, P., Aumont, J., Aurlien, R., Banerji, R., Barreiro, R. B., Bartlett, J. G., Basak, S., Battaglia, N., Bock, J., Boddy, K. K., Bonato, M., Borrill, J., Bouchet, F., Boulanger, F., Burkhart, B., Chluba, J., Chuss, D., Clark, S., Cooperrider, J., Crill, B. P., De Zotti, G., Delabrouille, J., Di Valentino, E., Didier, J., Dore, O., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Feeney, S., Filippini, J., Fissel, L., Flauger, R., Fuskeland, U., Gluscevic, V., Gorski, K. M., Green, D., Hensley, B., Herranz, D., Hill, J. C., Hivon, E., Hlozek, R., Hubmayr, J., Johnson, B. R., Jones, W., Jones, T., Knox, L., Kogut, A., Lopez-Caniego, M., Lawrence, C., Lazarian, A., Li, Z., Madhavacheril, M., Melin, J. B., Meyers, J., Murray, C., Negrello, M., Novak, G., O'Brient, R., Paine, C., Pearson, T., Pogosian, L., Pryke, C., Puglisi, G., Remazeilles, M., Rocha, G., Schmittfull, M., Scott, D., Shirron, P., Stephens, I., Sutin, B., Tomasi, M., Trangsrud, A., van Engelen, A., Vansyngel, F., Wehus, I. K., Wen, Q., Xu, S., Young, K., and Zonca, A.

Abstract

The Probe of Inflation and Cosmic Origins (PICO) is a proposed probe-scale space mission consisting of an imaging polarimeter operating in frequency bands between 20 and 800 GHz. We describe the science achievable by PICO, which has sensitivity equivalent to more than 3300 Planck missions, the technical implementation, the schedule and cost., Comment: APC White Paper submitted to the Astro2020 decadal panel; 10 page version of the 50 page mission study report arXiv:1902.10541

Published
2019

8. PICO: Probe of Inflation and Cosmic Origins

Author

Hanany, S., Alvarez, M., Artis, E., Ashton, P., Aumont, J., Aurlien, R., Banerji, R., Barreiro, R. B., Bartlett, J. G., Basak, S., Battaglia, N., Bock, J., Boddy, K. K., Bonato, M., Borrill, J., Bouchet, F., Boulanger, F., Burkhart, B., Chluba, J., Chuss, D., Clark, S., Cooperrider, J., Crill, B. P., De Zotti, G., Delabrouille, J., Di Valentino, E., Didier, J., Dore, O., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Feeney, S., Filippini, J., Fissel, L., Flauger, R., Fuskeland, U., Gluscevic, V., Gorski, K. M., Green, D., Hensley, B., Herranz, D., Hill, J. C., Hivon, E., Hlozek, R., Hubmayr, J., Johnson, B. R., Jones, W., Jones, T., Knox, L., Kogut, A., Lopez-Caniego, M., Lawrence, C., Lazarian, A., Li, Z., Madhavacheril, M., Melin, J. B., Meyers, J., Murray, C., Negrello, M., Novak, G., O'Brient, R., Paine, C., Pearson, T., Pogosian, L., Pryke, C., Puglisi, G., Remazeilles, M., Rocha, G., Schmittfull, M., Scott, D., Shirron, P., Stephens, I., Sutin, B., Tomasi, M., Trangsrud, A., van Engelen, A., Vansyngel, F., Wehus, I. K., Wen, Q., Xu, S., Young, K., Zonca, A., Hanany, S., Alvarez, M., Artis, E., Ashton, P., Aumont, J., Aurlien, R., Banerji, R., Barreiro, R. B., Bartlett, J. G., Basak, S., Battaglia, N., Bock, J., Boddy, K. K., Bonato, M., Borrill, J., Bouchet, F., Boulanger, F., Burkhart, B., Chluba, J., Chuss, D., Clark, S., Cooperrider, J., Crill, B. P., De Zotti, G., Delabrouille, J., Di Valentino, E., Didier, J., Dore, O., Eriksen, H. K., Errard, J., Essinger-Hileman, T., Feeney, S., Filippini, J., Fissel, L., Flauger, R., Fuskeland, U., Gluscevic, V., Gorski, K. M., Green, D., Hensley, B., Herranz, D., Hill, J. C., Hivon, E., Hlozek, R., Hubmayr, J., Johnson, B. R., Jones, W., Jones, T., Knox, L., Kogut, A., Lopez-Caniego, M., Lawrence, C., Lazarian, A., Li, Z., Madhavacheril, M., Melin, J. B., Meyers, J., Murray, C., Negrello, M., Novak, G., O'Brient, R., Paine, C., Pearson, T., Pogosian, L., Pryke, C., Puglisi, G., Remazeilles, M., Rocha, G., Schmittfull, M., Scott, D., Shirron, P., Stephens, I., Sutin, B., Tomasi, M., Trangsrud, A., van Engelen, A., Vansyngel, F., Wehus, I. K., Wen, Q., Xu, S., Young, K., and Zonca, A.

Abstract

The Probe of Inflation and Cosmic Origins (PICO) is a proposed probe-scale space mission consisting of an imaging polarimeter operating in frequency bands between 20 and 800 GHz. We describe the science achievable by PICO, which has sensitivity equivalent to more than 3300 Planck missions, the technical implementation, the schedule and cost., Comment: APC White Paper submitted to the Astro2020 decadal panel; 10 page version of the 50 page mission study report arXiv:1902.10541

Published
2019

9. Observation of electron-antineutrino disappearance at Daya Bay

Author

An, F. P., Bai, J. Z., Balantekin, A. B., Band, H. R., Beavis, D., Beriguete, W., Bishai, M., Blyth, S., Boddy, K., Brown, R. L., Cai, B., Cao, G. F., Cao, J., Carr, R., Chan, W. T., Chang, J. F., Chang, Y., Chasman, C., Chen, H. S., Chen, H. Y., Chen, S. J., Chen, S. M., Chen, X. C., Chen, X. H., Chen, X. S., Chen, Y., Chen, Y. X., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Deng, Z. Y., Ding, Y. Y., Diwan, M. V., Dong, L., Draeger, E., Du, X. F., Dwyer, D. A., Edwards, W. R., Ely, S. R., Fang, S. D., Fu, J. Y., Fu, Z. W., Ge, L. Q., Ghazikhanian, V., Gill, R. L., Goett, J., Gonchar, M., Gong, G. H., Gong, H., Gornushkin, Y. A., Greenler, L. S., Gu, W. Q., Guan, M. Y., Guo, X. H., Hackenburg, R. W., Hahn, R. L., Hans, S., He, M., He, Q., He, W. S., Heeger, K. M., Heng, Y. K., Hinrichs, P., Ho, T. H., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, T., Huang, H. X., Huang, H. Z., Huang, P. W., Huang, X., Huang, X. T., Huber, P., Isvan, Z., Jaffe, D. E., Jetter, S., Ji, X. L., Ji, X. P., Jiang, H. J., Jiang, W. Q., Jiao, J. B., Johnson, R. A., Kang, L., Kettell, S. H., Kramer, M., Kwan, K. K., Kwok, M. W., Kwok, T., Lai, C. Y., Lai, W. C., Lai, W. H., Lau, K., Lebanowski, L., Lee, J., Lee, M. K. P., Leitner, R., Leung, J. K. C., Leung, K. Y., Lewis, C. A., Li, B., Li, F., Li, G. S., Li, J., Li, Q. J., Li, S. F., Li, W. D., Li, X. B., Li, X. N., Li, X. Q., Li, Y., Li, Z. B., Liang, H., Liang, J., Lin, C. J., Lin, G. L., Lin, S. K., Lin, S. X., Lin, Y. C., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, B. J., Liu, C., Liu, D. W., Liu, H., Liu, J. C., Liu, J. L., Liu, S., Liu, X., Liu, Y. B., Lu, C., Lu, H. Q., Luk, A., Luk, K. B., Luo, T., Luo, X. L., Ma, L. H., Ma, Q. M., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mayes, B., McDonald, K. T., McFarlane, M. C., McKeown, R. D., Meng, Y., Mohapatra, D., Morgan, J. E., Nakajima, Y., Napolitano, J., Naumov, D., Nemchenok, I., Newsom, C., Ngai, H. Y., Ngai, W. K., Nie, Y. B., Ning, Z., Ochoa-Ricoux, J. P., Oh, D., Olshevski, A., Pagac, A., Patton, S., Pearson, C., Pec, V., Peng, J. C., Piilonen, L. E., Pinsky, L., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Rosero, R., Roskovec, B., Ruan, X. C., Seilhan, B., Shao, B. B., Shih, K., Steiner, H., Stoler, P., Sun, G. X., Sun, J. L., Tam, Y. H., Tanaka, H. K., Tang, X., Themann, H., Torun, Y., Trentalange, S., Tsai, O., Tsang, K. V., Tsang, R. H. M., Tull, C., Viren, B., Virostek, S., Vorobel, V., Wang, C. H., Wang, L. S., Wang, L. Y., Wang, L. Z., Wang, M., Wang, N. Y., Wang, R. G., Wang, T., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Webber, D. M., Wei, Y. D., Wen, L. J., Wenman, D. L., Whisnant, K., White, C. G., Whitehead, L., Whitten Jr., C. A., Wilhelmi, J., Wise, T., Wong, H. C., Wong, H. L. H., Wong, J., Worcester, E. T., Wu, F. F., Wu, Q., Xia, D. M., Xiang, S. T., Xiao, Q., Xing, Z. Z., Xu, G., Xu, J., Xu, J. L., Xu, W., Xu, Y., Xue, T., Yang, C. G., Yang, L., Ye, M., Yeh, M., Yeh, Y. S., Yip, K., Young, B. L., Yu, Z. Y., Zhan, L., Zhang, C., Zhang, F. H., Zhang, J. W., Zhang, Q. M., Zhang, K., Zhang, Q. X., Zhang, S. H., Zhang, Y. C., Zhang, Y. H., Zhang, Y. X., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, Q. W., Zhao, Y. B., Zheng, L., Zhong, W. L., Zhou, L., Zhou, Z. Y., Zhuang, H. L., Zou, J. H., An, F. P., Bai, J. Z., Balantekin, A. B., Band, H. R., Beavis, D., Beriguete, W., Bishai, M., Blyth, S., Boddy, K., Brown, R. L., Cai, B., Cao, G. F., Cao, J., Carr, R., Chan, W. T., Chang, J. F., Chang, Y., Chasman, C., Chen, H. S., Chen, H. Y., Chen, S. J., Chen, S. M., Chen, X. C., Chen, X. H., Chen, X. S., Chen, Y., Chen, Y. X., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Deng, Z. Y., Ding, Y. Y., Diwan, M. V., Dong, L., Draeger, E., Du, X. F., Dwyer, D. A., Edwards, W. R., Ely, S. R., Fang, S. D., Fu, J. Y., Fu, Z. W., Ge, L. Q., Ghazikhanian, V., Gill, R. L., Goett, J., Gonchar, M., Gong, G. H., Gong, H., Gornushkin, Y. A., Greenler, L. S., Gu, W. Q., Guan, M. Y., Guo, X. H., Hackenburg, R. W., Hahn, R. L., Hans, S., He, M., He, Q., He, W. S., Heeger, K. M., Heng, Y. K., Hinrichs, P., Ho, T. H., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, T., Huang, H. X., Huang, H. Z., Huang, P. W., Huang, X., Huang, X. T., Huber, P., Isvan, Z., Jaffe, D. E., Jetter, S., Ji, X. L., Ji, X. P., Jiang, H. J., Jiang, W. Q., Jiao, J. B., Johnson, R. A., Kang, L., Kettell, S. H., Kramer, M., Kwan, K. K., Kwok, M. W., Kwok, T., Lai, C. Y., Lai, W. C., Lai, W. H., Lau, K., Lebanowski, L., Lee, J., Lee, M. K. P., Leitner, R., Leung, J. K. C., Leung, K. Y., Lewis, C. A., Li, B., Li, F., Li, G. S., Li, J., Li, Q. J., Li, S. F., Li, W. D., Li, X. B., Li, X. N., Li, X. Q., Li, Y., Li, Z. B., Liang, H., Liang, J., Lin, C. J., Lin, G. L., Lin, S. K., Lin, S. X., Lin, Y. C., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, B. J., Liu, C., Liu, D. W., Liu, H., Liu, J. C., Liu, J. L., Liu, S., Liu, X., Liu, Y. B., Lu, C., Lu, H. Q., Luk, A., Luk, K. B., Luo, T., Luo, X. L., Ma, L. H., Ma, Q. M., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mayes, B., McDonald, K. T., McFarlane, M. C., McKeown, R. D., Meng, Y., Mohapatra, D., Morgan, J. E., Nakajima, Y., Napolitano, J., Naumov, D., Nemchenok, I., Newsom, C., Ngai, H. Y., Ngai, W. K., Nie, Y. B., Ning, Z., Ochoa-Ricoux, J. P., Oh, D., Olshevski, A., Pagac, A., Patton, S., Pearson, C., Pec, V., Peng, J. C., Piilonen, L. E., Pinsky, L., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Rosero, R., Roskovec, B., Ruan, X. C., Seilhan, B., Shao, B. B., Shih, K., Steiner, H., Stoler, P., Sun, G. X., Sun, J. L., Tam, Y. H., Tanaka, H. K., Tang, X., Themann, H., Torun, Y., Trentalange, S., Tsai, O., Tsang, K. V., Tsang, R. H. M., Tull, C., Viren, B., Virostek, S., Vorobel, V., Wang, C. H., Wang, L. S., Wang, L. Y., Wang, L. Z., Wang, M., Wang, N. Y., Wang, R. G., Wang, T., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Webber, D. M., Wei, Y. D., Wen, L. J., Wenman, D. L., Whisnant, K., White, C. G., Whitehead, L., Whitten Jr., C. A., Wilhelmi, J., Wise, T., Wong, H. C., Wong, H. L. H., Wong, J., Worcester, E. T., Wu, F. F., Wu, Q., Xia, D. M., Xiang, S. T., Xiao, Q., Xing, Z. Z., Xu, G., Xu, J., Xu, J. L., Xu, W., Xu, Y., Xue, T., Yang, C. G., Yang, L., Ye, M., Yeh, M., Yeh, Y. S., Yip, K., Young, B. L., Yu, Z. Y., Zhan, L., Zhang, C., Zhang, F. H., Zhang, J. W., Zhang, Q. M., Zhang, K., Zhang, Q. X., Zhang, S. H., Zhang, Y. C., Zhang, Y. H., Zhang, Y. X., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, Q. W., Zhao, Y. B., Zheng, L., Zhong, W. L., Zhou, L., Zhou, Z. Y., Zhuang, H. L., and Zou, J. H.

Abstract

The Daya Bay Reactor Neutrino Experiment has measured a non-zero value for the neutrino mixing angle $\theta_{13}$ with a significance of 5.2 standard deviations. Antineutrinos from six 2.9 GW$_{\rm th}$ reactors were detected in six antineutrino detectors deployed in two near (flux-weighted baseline 470 m and 576 m) and one far (1648 m) underground experimental halls. With a 43,000 ton-GW_{\rm th}-day livetime exposure in 55 days, 10416 (80376) electron antineutrino candidates were detected at the far hall (near halls). The ratio of the observed to expected number of antineutrinos at the far hall is $R=0.940\pm 0.011({\rm stat}) \pm 0.004({\rm syst})$. A rate-only analysis finds $\sin^22\theta_{13}=0.092\pm 0.016({\rm stat})\pm0.005({\rm syst})$ in a three-neutrino framework., Comment: 5 figures. Version to appear in Phys. Rev. Lett

Published
2012
Full Text
View/download PDF

10. Observation of electron-antineutrino disappearance at Daya Bay

Author

An, F. P., Bai, J. Z., Balantekin, A. B., Band, H. R., Beavis, D., Beriguete, W., Bishai, M., Blyth, S., Boddy, K., Brown, R. L., Cai, B., Cao, G. F., Cao, J., Carr, R., Chan, W. T., Chang, J. F., Chang, Y., Chasman, C., Chen, H. S., Chen, H. Y., Chen, S. J., Chen, S. M., Chen, X. C., Chen, X. H., Chen, X. S., Chen, Y., Chen, Y. X., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Deng, Z. Y., Ding, Y. Y., Diwan, M. V., Dong, L., Draeger, E., Du, X. F., Dwyer, D. A., Edwards, W. R., Ely, S. R., Fang, S. D., Fu, J. Y., Fu, Z. W., Ge, L. Q., Ghazikhanian, V., Gill, R. L., Goett, J., Gonchar, M., Gong, G. H., Gong, H., Gornushkin, Y. A., Greenler, L. S., Gu, W. Q., Guan, M. Y., Guo, X. H., Hackenburg, R. W., Hahn, R. L., Hans, S., He, M., He, Q., He, W. S., Heeger, K. M., Heng, Y. K., Hinrichs, P., Ho, T. H., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, T., Huang, H. X., Huang, H. Z., Huang, P. W., Huang, X., Huang, X. T., Huber, P., Isvan, Z., Jaffe, D. E., Jetter, S., Ji, X. L., Ji, X. P., Jiang, H. J., Jiang, W. Q., Jiao, J. B., Johnson, R. A., Kang, L., Kettell, S. H., Kramer, M., Kwan, K. K., Kwok, M. W., Kwok, T., Lai, C. Y., Lai, W. C., Lai, W. H., Lau, K., Lebanowski, L., Lee, J., Lee, M. K. P., Leitner, R., Leung, J. K. C., Leung, K. Y., Lewis, C. A., Li, B., Li, F., Li, G. S., Li, J., Li, Q. J., Li, S. F., Li, W. D., Li, X. B., Li, X. N., Li, X. Q., Li, Y., Li, Z. B., Liang, H., Liang, J., Lin, C. J., Lin, G. L., Lin, S. K., Lin, S. X., Lin, Y. C., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, B. J., Liu, C., Liu, D. W., Liu, H., Liu, J. C., Liu, J. L., Liu, S., Liu, X., Liu, Y. B., Lu, C., Lu, H. Q., Luk, A., Luk, K. B., Luo, T., Luo, X. L., Ma, L. H., Ma, Q. M., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mayes, B., McDonald, K. T., McFarlane, M. C., McKeown, R. D., Meng, Y., Mohapatra, D., Morgan, J. E., Nakajima, Y., Napolitano, J., Naumov, D., Nemchenok, I., Newsom, C., Ngai, H. Y., Ngai, W. K., Nie, Y. B., Ning, Z., Ochoa-Ricoux, J. P., Oh, D., Olshevski, A., Pagac, A., Patton, S., Pearson, C., Pec, V., Peng, J. C., Piilonen, L. E., Pinsky, L., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Rosero, R., Roskovec, B., Ruan, X. C., Seilhan, B., Shao, B. B., Shih, K., Steiner, H., Stoler, P., Sun, G. X., Sun, J. L., Tam, Y. H., Tanaka, H. K., Tang, X., Themann, H., Torun, Y., Trentalange, S., Tsai, O., Tsang, K. V., Tsang, R. H. M., Tull, C., Viren, B., Virostek, S., Vorobel, V., Wang, C. H., Wang, L. S., Wang, L. Y., Wang, L. Z., Wang, M., Wang, N. Y., Wang, R. G., Wang, T., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Webber, D. M., Wei, Y. D., Wen, L. J., Wenman, D. L., Whisnant, K., White, C. G., Whitehead, L., Whitten Jr., C. A., Wilhelmi, J., Wise, T., Wong, H. C., Wong, H. L. H., Wong, J., Worcester, E. T., Wu, F. F., Wu, Q., Xia, D. M., Xiang, S. T., Xiao, Q., Xing, Z. Z., Xu, G., Xu, J., Xu, J. L., Xu, W., Xu, Y., Xue, T., Yang, C. G., Yang, L., Ye, M., Yeh, M., Yeh, Y. S., Yip, K., Young, B. L., Yu, Z. Y., Zhan, L., Zhang, C., Zhang, F. H., Zhang, J. W., Zhang, Q. M., Zhang, K., Zhang, Q. X., Zhang, S. H., Zhang, Y. C., Zhang, Y. H., Zhang, Y. X., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, Q. W., Zhao, Y. B., Zheng, L., Zhong, W. L., Zhou, L., Zhou, Z. Y., Zhuang, H. L., Zou, J. H., An, F. P., Bai, J. Z., Balantekin, A. B., Band, H. R., Beavis, D., Beriguete, W., Bishai, M., Blyth, S., Boddy, K., Brown, R. L., Cai, B., Cao, G. F., Cao, J., Carr, R., Chan, W. T., Chang, J. F., Chang, Y., Chasman, C., Chen, H. S., Chen, H. Y., Chen, S. J., Chen, S. M., Chen, X. C., Chen, X. H., Chen, X. S., Chen, Y., Chen, Y. X., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Deng, Z. Y., Ding, Y. Y., Diwan, M. V., Dong, L., Draeger, E., Du, X. F., Dwyer, D. A., Edwards, W. R., Ely, S. R., Fang, S. D., Fu, J. Y., Fu, Z. W., Ge, L. Q., Ghazikhanian, V., Gill, R. L., Goett, J., Gonchar, M., Gong, G. H., Gong, H., Gornushkin, Y. A., Greenler, L. S., Gu, W. Q., Guan, M. Y., Guo, X. H., Hackenburg, R. W., Hahn, R. L., Hans, S., He, M., He, Q., He, W. S., Heeger, K. M., Heng, Y. K., Hinrichs, P., Ho, T. H., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, T., Huang, H. X., Huang, H. Z., Huang, P. W., Huang, X., Huang, X. T., Huber, P., Isvan, Z., Jaffe, D. E., Jetter, S., Ji, X. L., Ji, X. P., Jiang, H. J., Jiang, W. Q., Jiao, J. B., Johnson, R. A., Kang, L., Kettell, S. H., Kramer, M., Kwan, K. K., Kwok, M. W., Kwok, T., Lai, C. Y., Lai, W. C., Lai, W. H., Lau, K., Lebanowski, L., Lee, J., Lee, M. K. P., Leitner, R., Leung, J. K. C., Leung, K. Y., Lewis, C. A., Li, B., Li, F., Li, G. S., Li, J., Li, Q. J., Li, S. F., Li, W. D., Li, X. B., Li, X. N., Li, X. Q., Li, Y., Li, Z. B., Liang, H., Liang, J., Lin, C. J., Lin, G. L., Lin, S. K., Lin, S. X., Lin, Y. C., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, B. J., Liu, C., Liu, D. W., Liu, H., Liu, J. C., Liu, J. L., Liu, S., Liu, X., Liu, Y. B., Lu, C., Lu, H. Q., Luk, A., Luk, K. B., Luo, T., Luo, X. L., Ma, L. H., Ma, Q. M., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mayes, B., McDonald, K. T., McFarlane, M. C., McKeown, R. D., Meng, Y., Mohapatra, D., Morgan, J. E., Nakajima, Y., Napolitano, J., Naumov, D., Nemchenok, I., Newsom, C., Ngai, H. Y., Ngai, W. K., Nie, Y. B., Ning, Z., Ochoa-Ricoux, J. P., Oh, D., Olshevski, A., Pagac, A., Patton, S., Pearson, C., Pec, V., Peng, J. C., Piilonen, L. E., Pinsky, L., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Rosero, R., Roskovec, B., Ruan, X. C., Seilhan, B., Shao, B. B., Shih, K., Steiner, H., Stoler, P., Sun, G. X., Sun, J. L., Tam, Y. H., Tanaka, H. K., Tang, X., Themann, H., Torun, Y., Trentalange, S., Tsai, O., Tsang, K. V., Tsang, R. H. M., Tull, C., Viren, B., Virostek, S., Vorobel, V., Wang, C. H., Wang, L. S., Wang, L. Y., Wang, L. Z., Wang, M., Wang, N. Y., Wang, R. G., Wang, T., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Webber, D. M., Wei, Y. D., Wen, L. J., Wenman, D. L., Whisnant, K., White, C. G., Whitehead, L., Whitten Jr., C. A., Wilhelmi, J., Wise, T., Wong, H. C., Wong, H. L. H., Wong, J., Worcester, E. T., Wu, F. F., Wu, Q., Xia, D. M., Xiang, S. T., Xiao, Q., Xing, Z. Z., Xu, G., Xu, J., Xu, J. L., Xu, W., Xu, Y., Xue, T., Yang, C. G., Yang, L., Ye, M., Yeh, M., Yeh, Y. S., Yip, K., Young, B. L., Yu, Z. Y., Zhan, L., Zhang, C., Zhang, F. H., Zhang, J. W., Zhang, Q. M., Zhang, K., Zhang, Q. X., Zhang, S. H., Zhang, Y. C., Zhang, Y. H., Zhang, Y. X., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, Q. W., Zhao, Y. B., Zheng, L., Zhong, W. L., Zhou, L., Zhou, Z. Y., Zhuang, H. L., and Zou, J. H.

Abstract

The Daya Bay Reactor Neutrino Experiment has measured a non-zero value for the neutrino mixing angle $\theta_{13}$ with a significance of 5.2 standard deviations. Antineutrinos from six 2.9 GW$_{\rm th}$ reactors were detected in six antineutrino detectors deployed in two near (flux-weighted baseline 470 m and 576 m) and one far (1648 m) underground experimental halls. With a 43,000 ton-GW_{\rm th}-day livetime exposure in 55 days, 10416 (80376) electron antineutrino candidates were detected at the far hall (near halls). The ratio of the observed to expected number of antineutrinos at the far hall is $R=0.940\pm 0.011({\rm stat}) \pm 0.004({\rm syst})$. A rate-only analysis finds $\sin^22\theta_{13}=0.092\pm 0.016({\rm stat})\pm0.005({\rm syst})$ in a three-neutrino framework., Comment: 5 figures. Version to appear in Phys. Rev. Lett

Published
2012
Full Text
View/download PDF

11. Observation of Electron-Antineutrino Disappearance at Daya Bay

Author

Center for Neutrino Physics, Physics, An, F. P., Bai, J. Z., Balantekin, A. B., Band, H. R., Beavis, D., Beriguete, W., Bishai, M., Blyth, S., Boddy, K., Brown, R. L., Cai, B., Cao, G. F., Cao, J., Carr, Rachel E., Chan, W. T., Chang, J. F., Chang, Y., Chasman, C., Chen, H. S., Chen, H. Y., Chen, S. J., Chen, S. M., Chen, X. C., Chen, X. H., Chen, X. S., Chen, Y., Chen, Y. X., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Deng, Z. Y., Ding, Y. Y., Diwan, M. V., Dong, L., Draeger, E., Du, X. F., Dwyer, D. A., Edwards, W. R., Ely, S. R., Fang, S. D., Fu, J. Y., Fu, Z. W., Ge, L. Q., Ghazikhanian, V., Gill, R. L., Goett, J., Gonchar, M., Gong, G. H., Gong, H., Gornushkin, Y. A., Greenler, L. S., Gu, W. Q., Guan, M. Y., Guo, X. H., Hackenburg, R. W., Hahn, R. L., Hans, S., He, M., He, Q., He, W. S., Heeger, K. M., Heng, Y. K., Hinrichs, P., Ho, T. H., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, T., Huang, H. X., Huang, H. Z., Huang, P. W., Huang, X., Huang, X. T., Huber, Patrick, Isvan, Z., Jaffe, D. E., Jetter, S., Ji, X. L., Ji, X. P., Jiang, H. J., Jiang, W. Q., Jiao, J. B., Johnson, R. A., Kang, L., Kettell, S. H., Kramer, M., Kwan, K. K., Kwok, M. W., Kwok, T., Lai, C. Y., Lai, W. C., Lai, W. H., Lau, K., Lebanowski, L., Lee, J., Lee, M. K. P., Leitner, R., Leung, J. K. C., Leung, K. Y., Lewis, C. A., Li, B., Li, F., Li, G. S., Li, J., Li, Q. J., Li, S. F., Li, W. D., Li, X. B., Li, X. N., Li, X. Q., Li, Y., Li, Z. B., Liang, H., Liang, J., Lin, C. J., Lin, G. L., Lin, S. K., Lin, S. X., Lin, Y. C., Ling, J. J., Link, Jonathan M., Littenberg, L., Littlejohn, B. R., Liu, B. J., Liu, C., Liu, D. W., Liu, H., Liu, J. C., Liu, J. L., Liu, S., Liu, X., Liu, Y. B., Lu, C., Lu, H. Q., Luk, A., Luk, K. B., Luo, T., Luo, X. L., Ma, L. H., Ma, Q. M., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mayes, B., McDonald, K. T., McFarlane, M. C., McKeown, R. D., Meng, Y., Mohapatra, D., Morgan, J. E., Nakajima, Y., Napolitano, J., Naumov, D., Nemchenok, I., Newsom, C., Ngai, H. Y., Ngai, W. K., Nie, Y. B., Ning, Z., Ochoa-Ricoux, J. P., Oh, D., Olshevski, A., Pagac, A., Patton, S., Pearson, C., Pec, V., Peng, J. C., Piilonen, Leo E., Pinsky, L., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Rosero, R., Roskovec, B., Ruan, X. C., Seilhan, B., Shao, B. B., Shih, K., Steiner, H., Stoler, P., Sun, G. X., Sun, J. L., Tam, Y. H., Tanaka, H. K., Tang, X., Themann, H., Torun, Y., Trentalange, S., Tsai, O., Tsang, K. V., Tsang, R. H. M., Tull, C., Viren, B., Virostek, S., Vorobel, V., Wang, C. H., Wang, L. S., Wang, L. Y., Wang, L. Z., Wang, M., Wang, N. Y., Wang, R. G., Wang, T., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Webber, D. M., Wei, Y. D., Wen, L. J., Wenman, D. L., Whisnant, K., White, C. G., Whitehead, L., Whitten, C. A., Wilhelmi, J., Wise, T., Wong, H. C., Wong, H. L. H., Wong, J., Worcester, E., Wu, F. F., Wu, Q., Xia, D. M., Xiang, S. 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Abstract

The Daya Bay Reactor Neutrino Experiment has measured a nonzero value for the neutrino mixing angle 0(13) with a significance of 5.2 standard deviations. Antineutrinos from six 2.9 GW(th) reactors were detected in six antineutrino detectors deployed in two near (flux-weighted baseline 470 m and 576 m) and one far (1648 m) underground experimental halls. With a 43 000 ton-GW(th)-day live-time exposure in 55 days, 10 416 (80 376) electron-antineutrino candidates were detected at the far hall (near halls). The ratio of the observed to expected number of antineutrinos at the far hall is R = 0.940 +/- 0.011(stat.) +/- 0.004(syst.). A rate-only analysis finds sin(2)2 theta(13) = 0.092 +/- 0.016(stat.) +/- 0.005(syst.) in a three-neutrino framework.

Published
2012

12. Measuring the cost-effectiveness of treatments for people with multiple sclerosis: Beyond quality-adjusted life-years.

Author

Hawton, A., Goodwin, E., Boddy, K., Freeman, J., Thomas, Sarah, Chataway, J., Green, C., Hawton, A., Goodwin, E., Boddy, K., Freeman, J., Thomas, Sarah, Chataway, J., and Green, C.

Abstract

BACKGROUND: It is a familiar story. A promising multiple sclerosis (MS) treatment clears the three regulatory hurdles of safety, quality and efficacy, only to fall at the fourth: cost-effectiveness. This has led to concerns about the validity of the measures typically used to quantify treatment effects in cost-effectiveness analyses and in 2012, in the United Kingdom, the National Institute for Health and Care Excellence called for an improvement in the cost-effectiveness framework for assessing MS treatments. OBJECTIVE AND METHODS: This review describes what is meant by cost-effectiveness in health/social care funding decision-making, and usual practice for assessing treatment benefits. RESULTS: We detail the use of the quality-adjusted life-year (QALY) in resource allocation decisions, and set out limitations of this approach in the context of MS. CONCLUSION: We conclude by highlighting methodological and policy developments which should aid addressing these limitations.

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