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1. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper (vol 12, 100080, 2020)

Author

Ansotegui, IJ, Melioli, G, Canonica, GW, Caraballo, L, Villa, E, Ebisawa, M, Passalacqua, G, Savi, E, Ebo, D, Gomez, RM, Sanchez, OL, Oppenheimer, JJ, Jensen-Jarolim, E, Fischer, DA, Haahtela, T, Antila, M, Bousquet, JJ, Cardona, V, Chiang, WC, Demoly, PM, DuBuske, LM, Puga, MF, Wijk, RGV, Diaz, SNG, Gonzalez-Estrada, A, Jares, E, Kalpaklioglu, AF, Tanno, LK, Kowalski, ML, Ledford, DK, Ortega, OPM, Morais-Almeida, M, Pfaar, O, Poulsen, LK, Pawankar, R, Renz, HE, Romano, AG, Rosario Filho, NA, Rosenwasser, L, Borges, MAS, Scala, E, Senna, G-E, Sisul, JC, Tang, MLK, Thong, BY-H, Valenta, R, Wood, RA, Zuberbier, T, Ansotegui, IJ, Melioli, G, Canonica, GW, Caraballo, L, Villa, E, Ebisawa, M, Passalacqua, G, Savi, E, Ebo, D, Gomez, RM, Sanchez, OL, Oppenheimer, JJ, Jensen-Jarolim, E, Fischer, DA, Haahtela, T, Antila, M, Bousquet, JJ, Cardona, V, Chiang, WC, Demoly, PM, DuBuske, LM, Puga, MF, Wijk, RGV, Diaz, SNG, Gonzalez-Estrada, A, Jares, E, Kalpaklioglu, AF, Tanno, LK, Kowalski, ML, Ledford, DK, Ortega, OPM, Morais-Almeida, M, Pfaar, O, Poulsen, LK, Pawankar, R, Renz, HE, Romano, AG, Rosario Filho, NA, Rosenwasser, L, Borges, MAS, Scala, E, Senna, G-E, Sisul, JC, Tang, MLK, Thong, BY-H, Valenta, R, Wood, RA, and Zuberbier, T

Abstract

[This corrects the article DOI: 10.1016/j.waojou.2019.100080.].

Published
2021

2. IgE allergy diagnostics and other relevant tests in allergy, a World Allergy Organization position paper

Author

Ansotegui, IJ, Melioli, G, Canonica, GW, Caraballo, L, Villa, E, Ebisawa, M, Passalacqua, G, Savi, E, Ebo, D, Maximiliano Gomez, R, Luengo Sanchez, O, Oppenheimer, JJ, Jensen-Jarolim, E, Fischer, DA, Haahtela, T, Antila, M, Bousquet, JJ, Cardona, V, Chiang, WC, Demoly, PM, DuBuske, LM, Ferrer Puga, M, van Wijk, RG, Gonzalez Diaz, SN, Gonzalez-Estrada, A, Jares, E, Kalpaklioglu, AF, Tanno, LK, Kowalski, ML, Ledford, DK, Monge Ortega, OP, Almeida, MM, Pfaar, O, Poulsen, LK, Pawankar, R, Renz, HE, Romano, AG, Rosario Filho, NA, Rosenwasser, L, Sanchez Borges, MA, Scala, E, Senna, G-E, Carlos Sisul, J, Tang, MLK, Thong, BY-H, Valenta, R, Wood, RA, Zuberbier, T, Ansotegui, IJ, Melioli, G, Canonica, GW, Caraballo, L, Villa, E, Ebisawa, M, Passalacqua, G, Savi, E, Ebo, D, Maximiliano Gomez, R, Luengo Sanchez, O, Oppenheimer, JJ, Jensen-Jarolim, E, Fischer, DA, Haahtela, T, Antila, M, Bousquet, JJ, Cardona, V, Chiang, WC, Demoly, PM, DuBuske, LM, Ferrer Puga, M, van Wijk, RG, Gonzalez Diaz, SN, Gonzalez-Estrada, A, Jares, E, Kalpaklioglu, AF, Tanno, LK, Kowalski, ML, Ledford, DK, Monge Ortega, OP, Almeida, MM, Pfaar, O, Poulsen, LK, Pawankar, R, Renz, HE, Romano, AG, Rosario Filho, NA, Rosenwasser, L, Sanchez Borges, MA, Scala, E, Senna, G-E, Carlos Sisul, J, Tang, MLK, Thong, BY-H, Valenta, R, Wood, RA, and Zuberbier, T

Abstract

Currently, testing for immunoglobulin E (IgE) sensitization is the cornerstone of diagnostic evaluation in suspected allergic conditions. This review provides a thorough and updated critical appraisal of the most frequently used diagnostic tests, both in vivo and in vitro. It discusses skin tests, challenges, and serological and cellular in vitro tests, and provides an overview of indications, advantages and disadvantages of each in conditions such as respiratory, food, venom, drug, and occupational allergy. Skin prick testing remains the first line approach in most instances; the added value of serum specific IgE to whole allergen extracts or components, as well as the role of basophil activation tests, is evaluated. Unproven, non-validated, diagnostic tests are also discussed. Throughout the review, the reader must bear in mind the relevance of differentiating between sensitization and allergy; the latter entails not only allergic sensitization, but also clinically relevant symptoms triggered by the culprit allergen.

Published
2020

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