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Patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) frequently relapse on imatinib with acquisition of BCR-ABL kinase domain (KD) mutations. To analyze the changes that second-generation tyrosine kinase inhibitors (TKIs) have brought in mutation frequency and type, a database review was undertaken of the results of all the BCR-ABL KD mutation analyses performed in the authors' laboratory from January 2004 to January 2013.

Patients with Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) frequently relapse on imatinib with acquisition of BCR-ABL kinase domain (KD) mutations. To analyze the changes that second-generation tyrosine kinase inhibitors (TKIs) have brought in mutation frequency and type, a database review was undertaken of the results of all the BCR-ABL KD mutation analyses performed in the authors' laboratory from January 2004 to January 2013.

7th International Bi-Conference Workshop, AOIS 2005, Utrecht, Netherlands, July 26, 2005, and Klagenfurt, Austria, October 27, 2005, Contains fulltext : 56937.pdf (publisher's version ) (Closed access), The aim of requirements analysis for an agent that is to be designed is to identify what characteristic capabilities the agent should have. One of the characteristics usually expected for intelligent agents is the capability of reasoning. This paper shows how a requirements analysis of an agent's reasoning capability can be made. Reasoning processes may involve dynamically introduced or retracted assumptions: 'reasoning by assumption'. It is shown for this type of reasoning how relevant dynamic properties at different levels of aggregation can be identified as requirements that characterize the reasoning capability. A software agent has been built that performs this type of reasoning. The dynamic properties have been expressed using the temporal trace language TTL and can and have been checked automatically for sample traces.

7th International Bi-Conference Workshop, AOIS 2005, Utrecht, Netherlands, July 26, 2005, and Klagenfurt, Austria, October 27, 2005, Contains fulltext : 56937.pdf (publisher's version ) (Closed access), The aim of requirements analysis for an agent that is to be designed is to identify what characteristic capabilities the agent should have. One of the characteristics usually expected for intelligent agents is the capability of reasoning. This paper shows how a requirements analysis of an agent's reasoning capability can be made. Reasoning processes may involve dynamically introduced or retracted assumptions: 'reasoning by assumption'. It is shown for this type of reasoning how relevant dynamic properties at different levels of aggregation can be identified as requirements that characterize the reasoning capability. A software agent has been built that performs this type of reasoning. The dynamic properties have been expressed using the temporal trace language TTL and can and have been checked automatically for sample traces.

7th International Bi-Conference Workshop, AOIS 2005, Utrecht, Netherlands, July 26, 2005, and Klagenfurt, Austria, October 27, 2005, Contains fulltext : 56937.pdf (publisher's version ) (Closed access), The aim of requirements analysis for an agent that is to be designed is to identify what characteristic capabilities the agent should have. One of the characteristics usually expected for intelligent agents is the capability of reasoning. This paper shows how a requirements analysis of an agent's reasoning capability can be made. Reasoning processes may involve dynamically introduced or retracted assumptions: 'reasoning by assumption'. It is shown for this type of reasoning how relevant dynamic properties at different levels of aggregation can be identified as requirements that characterize the reasoning capability. A software agent has been built that performs this type of reasoning. The dynamic properties have been expressed using the temporal trace language TTL and can and have been checked automatically for sample traces.

The growth of interest in agent-orientation as a new paradigm has introduced the need for developing concepts, tools and techniques for modeling and engineering agent-based software systems. Object technology has been supporting the development of information systems for many years but is now slowly evolving to encompass more recent ideas relating to the concept of "agent". Integrating agent concepts into existing OO methodologies has resulted in several agent-oriented methodologies, one of which is Agent OPEN. In this paper, we evaluate the existing Agent OPEN description against ideas formulated within Tropos, an agent-oriented software development methodology. © Springer-Verlag Berlin Heidelberg 2004.

The growth of interest in agent-orientation as a new paradigm has introduced the need for developing concepts, tools and techniques for modeling and engineering agent-based software systems. Object technology has been supporting the development of information systems for many years but is now slowly evolving to encompass more recent ideas relating to the concept of "agent". Integrating agent concepts into existing OO methodologies has resulted in several agent-oriented methodologies, one of which is Agent OPEN. In this paper, we evaluate the existing Agent OPEN description against ideas formulated within Tropos, an agent-oriented software development methodology. © Springer-Verlag Berlin Heidelberg 2004.

Methodologies involves both process elements and product elements. The OPEN Process Framework (OPF) focusses largely on process elements in the context of object-oriented systems development. The Tropos metamodel, on the other hand, focusses on early requirements engineering support for agent-oriented development. In a project to extend the OPF to support agent-oriented developments, we investigate the potential for amalgamation of these two methodological approaches and their metamodels, describing how the metamodel integration has been initiated.

Methodologies involves both process elements and product elements. The OPEN Process Framework (OPF) focusses largely on process elements in the context of object-oriented systems development. The Tropos metamodel, on the other hand, focusses on early requirements engineering support for agent-oriented development. In a project to extend the OPF to support agent-oriented developments, we investigate the potential for amalgamation of these two methodological approaches and their metamodels, describing how the metamodel integration has been initiated.