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Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and redox imbalance. Ferroptosis shows specific biological and morphological features when compared to the other cell death patterns. The loss of lipid peroxide repair activity by glutathione peroxidase 4 (GPX4), the presence of redox-active iron and the oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids are considered as distinct fingerprints of ferroptosis. Several pathways, including amino acid and iron metabolism, ferritinophagy, cell adhesion, p53, Keap1/Nrf2 and phospholipid biosynthesis, can modify susceptibility to ferroptosis. Through the decades, various diseases, including acute kidney injury; cancer; ischemia–reperfusion injury; and cardiovascular, neurodegenerative and hepatic disorders, have been associated with ferroptosis. In this review, we provide a comprehensive analysis of the main biological and biochemical mechanisms of ferroptosis and an overview of chemicals used as inducers and inhibitors. Then, we report the contribution of ferroptosis to the spectrum of liver diseases, acute or chronic. Finally, we discuss the use of ferroptosis as a therapeutic approach against hepatocellular carcinoma, the most common form of primary liver cancer.

Thermal expansion coefficients, α, excess thermal expansion coefficients, αE, isothermal coefficients of pressure excess molar enthalpy, (∂HE/∂p)T,x, partial molar volumes, V¯i, partial molar volumes at infinite dilution, V¯i∞, partial excess molar volumes, V¯Ei, and partial excess molar volumes at infinite dilution, V¯Ei∞, were calculated using experimental densities and excess molar volumes, VE, data. All calculations are performed for the binary systems of cyclohexylamine with 1-propanol or 1-butanol or 2-butanol or 2-methyl-2-propanol. The Redlich-Kister polynomial and the reduced excess molar volume approach were used in the evaluation of these properties. In addition, the aim of this investigation was to provide a set of various volumetric data in order to asses the influence of temperature, chain length and position of hydroxyl group in the alcohol molecule on the molecular interactions in the examined binary mixtures., Termički koeficijent ekspanzije, α, dopunski termički koeficijent, αE, izotermski koeficijent pritiska dopunske molarne entalpije, (∂HE/∂p)T,x, parcijalne molarne zapremine, V¯i, parcijalne molarne zapremine pri beskonačnom razblaženju, V¯i∞, parcijalne dopunske molarne zapremine, V¯Ei, i parcijalne dopunske molarne zapremine pri beskonačnom razblaženju, V¯Ei∞, su izračunate iz eksperimentalnih podataka za gustine i podataka za dopunske molarne zapremine VE. Svi proračuni su izveršeni na binarnim smešama cikloheksilamina sa 1-propanolom, ili 1-butanolom, ili 2-butanolom, ili 2-metil-2-propanolom. Polinom Redlich-Kister-a i pristup redukovane dopunske molarne zapremine su korišćeni u izračunavanju ovih osobina. Pri tome, cilj ovog istraživanja je bio da se odredi set različitih volumetrijskih podataka da bi se procenio uticaj temperature, dužine lanca i položaja hidroksilne grupe u molekulu alkohola na molekulske interakcije u ispitivanim binarnim smešama.

Thermal expansion coefficients, a. excess thermal expansion coefficients, alpha(E), isothermal coefficients of pressure excess molar enthalpy, (partial derivative H(E)/partial derivative p)T(,x), partial molar volumes, (V) over bar (i), partial molar volumes at infinite dilution, (V) over bar (infinity)(i), partial excess molar volumes, (V) over bar (E)(i), and partial excess molar volumes at infinite dilution, (V) over bar (E,infinity)(i), were calculated using experimental densities and excess molar volumes, V(E), data. All calculations are performed for the binary systems of cyclohexylamine with 1-propanol or 1-butanol or 2-butanol or 2-methyl-2-propanol. The Redlich-Kister polynomial and the reduced excess molar volume approach were used in the evaluation of these properties. In addition, the aim of this investigation was to provide a set of various volumetric data in order to asses the influence of temperature, chain length and position of hydroxyl group in the alcohol molecule oil the molecular interactions in the examined binary mixtures.

Thermal expansion coefficients, a. excess thermal expansion coefficients, alpha(E), isothermal coefficients of pressure excess molar enthalpy, (partial derivative H(E)/partial derivative p)T(,x), partial molar volumes, (V) over bar (i), partial molar volumes at infinite dilution, (V) over bar (infinity)(i), partial excess molar volumes, (V) over bar (E)(i), and partial excess molar volumes at infinite dilution, (V) over bar (E,infinity)(i), were calculated using experimental densities and excess molar volumes, V(E), data. All calculations are performed for the binary systems of cyclohexylamine with 1-propanol or 1-butanol or 2-butanol or 2-methyl-2-propanol. The Redlich-Kister polynomial and the reduced excess molar volume approach were used in the evaluation of these properties. In addition, the aim of this investigation was to provide a set of various volumetric data in order to asses the influence of temperature, chain length and position of hydroxyl group in the alcohol molecule oil the molecular interactions in the examined binary mixtures.

Experimental densities rho and excess molar volumes V-E of one ternary and three binary systems containing 1-butanol, cyclohexylamine and n-heptane at temperatures from 283.15 to 323.15 K are reported. Density measurements were performed by ail Anton Paar DMA 5000 vibrating tube densimeter. The obtained V-E of binary systems were fitted to the Redlich-Kister equation, and to the Nagata-Tamura equation for the ternary system. For the correlation of V-E data of binary systems van der Waals (vdW1) and Twu-Coon-Bluck-Tilton (TCBT) mixing rules coupled with the Peng-Robinson-Stryjek-Vera (PRSV) equation of state were applied. The same models were applied for the prediction and correlation of V-E data of the ternary system. In addition, several empirical relationships were applied for the prediction of V-E data of the ternary system from the corresponding binary data. The obtained results have been analysed in terms of specific molecular interactions present in the investigated mixtures taking into considerations the effect of temperature increasing on present interactions.

Densities of binary mixtures of 1-propanol, or 2-butanol, or 1-pentanol + cyclohexylamine were measured at temperatures from 288.15 to 313.15 K and atmospheric pressure, while the densities for the system 2-methyl-2-propanol + cyclohexylamine were measured at temperatures from 303.15 to 323.15 K and atmospheric pressure. All measurements were performed using an Anton Paar DMA 5000 digital vibrating-tube densimeter. From the experimental densities, the excess molar volumes, VE, were calculated., Gustine binarnih smeša (1-propanol ili 2-butanol ili 1-pentanol + cikloheksilamin) su merene u temperaturnom intervalu 288,15-313,15 K i na atmosferskom pritisku, a gustine sistema 2-metil-2-propanol + cikloheksilamin su merene u temperaturnom intervalu 303,15-323,15 K i na atmosferskom pritisku. Sva merenja su izvršena na Anton Paar DMA 5000 digitalnom gustinomeru. Iz eksperimentalnih vrednosti gustina izračunate su dopunske molarne zapremine navedenih smeša.

Experimental densities rho and excess molar volumes V-E of one ternary and three binary systems containing 1-butanol, cyclohexylamine and n-heptane at temperatures from 283.15 to 323.15 K are reported. Density measurements were performed by ail Anton Paar DMA 5000 vibrating tube densimeter. The obtained V-E of binary systems were fitted to the Redlich-Kister equation, and to the Nagata-Tamura equation for the ternary system. For the correlation of V-E data of binary systems van der Waals (vdW1) and Twu-Coon-Bluck-Tilton (TCBT) mixing rules coupled with the Peng-Robinson-Stryjek-Vera (PRSV) equation of state were applied. The same models were applied for the prediction and correlation of V-E data of the ternary system. In addition, several empirical relationships were applied for the prediction of V-E data of the ternary system from the corresponding binary data. The obtained results have been analysed in terms of specific molecular interactions present in the investigated mixtures taking into considerations the effect of temperature increasing on present interactions.

Densities of binary mixtures of 1-propanol, or 2-butanol, or 1-pentanol + cyclohexylamine were measured at temperatures from 288.15 to 313.15 K and atmospheric pressure, while the densities for the system 2-methyl-2-propanol + cyclohexylamine were measured at temperatures from 303.15 to 323.15 K and atmospheric pressure. All measurements were performed using an Anton Paar DMA 5000 digital vibrating-tube densimeter. From the experimental densities, the excess molar volumes, VE, were calculated., Gustine binarnih smeša (1-propanol ili 2-butanol ili 1-pentanol + cikloheksilamin) su merene u temperaturnom intervalu 288,15-313,15 K i na atmosferskom pritisku, a gustine sistema 2-metil-2-propanol + cikloheksilamin su merene u temperaturnom intervalu 303,15-323,15 K i na atmosferskom pritisku. Sva merenja su izvršena na Anton Paar DMA 5000 digitalnom gustinomeru. Iz eksperimentalnih vrednosti gustina izračunate su dopunske molarne zapremine navedenih smeša.

Hydrothermal synthesis of CoAPSO-44 in the presence of cyclohexylamine (CHA) as the template is generally accompanied by the formation of an unknown phase, “Co(APSO)N.” Electronic spectroscopy indicates that CO(APSO)N contains Co2+ in a pentacoordinated environment. When Co(APSO)N is heated at 195°C in a water suspension under autogenic pressure, two processes occur: (a) a partial conversion of Co(APSO)N into CoAPSO-44 and (b) decomposition of Co(APSO)N into Co- and Al-phosphates. Thermal removal of CHA from Co(APSO)N results in a breakdown of the latter's cyrstal lattice.

Hydrothermal synthesis of CoAPSO-44 in the presence of cyclohexylamine (CHA) as the template is generally accompanied by the formation of an unknown phase, “Co(APSO)N.” Electronic spectroscopy indicates that CO(APSO)N contains Co2+ in a pentacoordinated environment. When Co(APSO)N is heated at 195°C in a water suspension under autogenic pressure, two processes occur: (a) a partial conversion of Co(APSO)N into CoAPSO-44 and (b) decomposition of Co(APSO)N into Co- and Al-phosphates. Thermal removal of CHA from Co(APSO)N results in a breakdown of the latter's cyrstal lattice.

Viscosity values were measured at 30-90C for the following amines: pyrrole, indole, pyrrolidine, aniline, piperidine, cyclohexylamine, and eta-hexylamine. The p was measured pycnometrically and eta by Ostwald's capillary voscometer. The temperature dependence of p and eta of amines is described with given correlations. Values of alpha, A, B, and a given value (activation energy of viscous flow) are tabulated. Comparison of given values (latent heat of vaporization at boiling point) concluded that various type cyclic amines are subject to noticeable self-association in the liquid state. (Author), Edited machine trans. of Politehnicheskii Institut, Kharkov. Vestnik (USSR) n2 p18-22 1967, by Charles T. Ostertag.

Восстановлением N,3,5-замещенных 4-нитрозоанилинов гидразингидратом на Pd/C получены N-3,5-замещенные 1,4-фенилендиамины. Синтез N-((1-адамантил)метил)-3,5-замещенных 4-нитрозоанилинов впервые осуществлен конденсацией 2-гидроксимино-1,3-дикетонов с ацетоном и (1- адамантил)метанамином в пиридине., N,3,5-Substituted 1,4-phenylenediamines were obtained by reduction of N,3,5-substituted 4-nitosoanilines by hydrazinehydrate on the Pd/C. N-((1-Аdamatyl)methyl)-3,5-substituted 4-nitrosoanilines were first synthesized by condensation of 2-hydroxyimino-1,3-diketone with acetone and (1-adamatyl)methanamine in pyridine.

Восстановлением N,3,5-замещенных 4-нитрозоанилинов гидразингидратом на Pd/C получены N-3,5-замещенные 1,4-фенилендиамины. Синтез N-((1-адамантил)метил)-3,5-замещенных 4-нитрозоанилинов впервые осуществлен конденсацией 2-гидроксимино-1,3-дикетонов с ацетоном и (1- адамантил)метанамином в пиридине., N,3,5-Substituted 1,4-phenylenediamines were obtained by reduction of N,3,5-substituted 4-nitosoanilines by hydrazinehydrate on the Pd/C. N-((1-Аdamatyl)methyl)-3,5-substituted 4-nitrosoanilines were first synthesized by condensation of 2-hydroxyimino-1,3-diketone with acetone and (1-adamatyl)methanamine in pyridine.

Восстановлением N,3,5-замещенных 4-нитрозоанилинов гидразингидратом на Pd/C получены N-3,5-замещенные 1,4-фенилендиамины. Синтез N-((1-адамантил)метил)-3,5-замещенных 4-нитрозоанилинов впервые осуществлен конденсацией 2-гидроксимино-1,3-дикетонов с ацетоном и (1- адамантил)метанамином в пиридине., N,3,5-Substituted 1,4-phenylenediamines were obtained by reduction of N,3,5-substituted 4-nitosoanilines by hydrazinehydrate on the Pd/C. N-((1-Аdamatyl)methyl)-3,5-substituted 4-nitrosoanilines were first synthesized by condensation of 2-hydroxyimino-1,3-diketone with acetone and (1-adamatyl)methanamine in pyridine.