1. Prdm4 induction by the small molecule butein promotes white adipose tissue browning.
- Author
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Song, No-Joon, Song, No-Joon, Choi, Seri, Rajbhandari, Prashant, Chang, Seo-Hyuk, Kim, Suji, Vergnes, Laurent, Kwon, So-Mi, Yoon, Jung-Hoon, Lee, Sukchan, Ku, Jin-Mo, Lee, Jeong-Soo, Reue, Karen, Koo, Seung-Hoi, Tontonoz, Peter, Park, Kye Won, Song, No-Joon, Song, No-Joon, Choi, Seri, Rajbhandari, Prashant, Chang, Seo-Hyuk, Kim, Suji, Vergnes, Laurent, Kwon, So-Mi, Yoon, Jung-Hoon, Lee, Sukchan, Ku, Jin-Mo, Lee, Jeong-Soo, Reue, Karen, Koo, Seung-Hoi, Tontonoz, Peter, and Park, Kye Won
- Abstract
Increasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue.
- Published
- 2016