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1. Distribution of SV2C mRNA and protein expression in the mouse brain with a particular emphasis on the basal ganglia system.

Author

Dardou, David, Dassesse, Donald, Cuvelier, Laetitia, Deprez, T, De Ryck, Michel, Schiffmann, Serge N., Dardou, David, Dassesse, Donald, Cuvelier, Laetitia, Deprez, T, De Ryck, Michel, and Schiffmann, Serge N.

Abstract

Synaptic vesicle 2 proteins (SV2), SV2A, SV2B and SV2C, are integral proteins localized on the surface of synaptic vesicles in all neurons. SV2 proteins appear to play an important, but not yet fully understood role in synaptic vesicle exocytosis and neurotransmitter release. Moreover, SV2 seems to be the receptor of the botulinum neurotoxin A. In the present study, using single and double-labeling fluorescent immunohistochemistry and in situ hybridization we have identified the brain pattern of SV2C mRNA and protein expression in mice. Our results indicated that SV2C protein was expressed in a small subset of brain regions including the olfactory bulb, olfactory tubercle, nucleus accumbens, caudate-putamen, ventral pallidum, globus pallidus, substantia nigra and the ventral tegmental area. These results were confirmed by means of in situ hybridization, except for the globus pallidus and the substantia nigra pars reticulata, in which no labeling was found, suggesting that SV2C-positive fibers in these areas are terminals of striatal projecting neurons. In the striatum, we found that, in addition to its presence in the projection neurons, SV2C was densely expressed in a fraction (around 45%) of cholinergic interneurons. In addition, our data also showed that SV2C was densely expressed in most dopaminergic neurons in the substantia nigra pars compacta and the ventral tegmental area (more than 70% of the dopaminergic neurons analyzed were SV2C-positive). Altogether, our results suggest that SV2C may contribute to the regulation of neurotransmitter release and synaptic transmission in the basal ganglia including cholinergic striatal interneurons and nigro-striatal/mesolimbic dopamine neurons., Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2011

2. Distribution of SV2C mRNA and protein expression in the mouse brain with a particular emphasis on the basal ganglia system.

Author

Dardou, David, Dassesse, Donald, Cuvelier, Laetitia, Deprez, T, De Ryck, Michel, Schiffmann, Serge N., Dardou, David, Dassesse, Donald, Cuvelier, Laetitia, Deprez, T, De Ryck, Michel, and Schiffmann, Serge N.

Abstract

Synaptic vesicle 2 proteins (SV2), SV2A, SV2B and SV2C, are integral proteins localized on the surface of synaptic vesicles in all neurons. SV2 proteins appear to play an important, but not yet fully understood role in synaptic vesicle exocytosis and neurotransmitter release. Moreover, SV2 seems to be the receptor of the botulinum neurotoxin A. In the present study, using single and double-labeling fluorescent immunohistochemistry and in situ hybridization we have identified the brain pattern of SV2C mRNA and protein expression in mice. Our results indicated that SV2C protein was expressed in a small subset of brain regions including the olfactory bulb, olfactory tubercle, nucleus accumbens, caudate-putamen, ventral pallidum, globus pallidus, substantia nigra and the ventral tegmental area. These results were confirmed by means of in situ hybridization, except for the globus pallidus and the substantia nigra pars reticulata, in which no labeling was found, suggesting that SV2C-positive fibers in these areas are terminals of striatal projecting neurons. In the striatum, we found that, in addition to its presence in the projection neurons, SV2C was densely expressed in a fraction (around 45%) of cholinergic interneurons. In addition, our data also showed that SV2C was densely expressed in most dopaminergic neurons in the substantia nigra pars compacta and the ventral tegmental area (more than 70% of the dopaminergic neurons analyzed were SV2C-positive). Altogether, our results suggest that SV2C may contribute to the regulation of neurotransmitter release and synaptic transmission in the basal ganglia including cholinergic striatal interneurons and nigro-striatal/mesolimbic dopamine neurons., Journal Article, Research Support, Non-U.S. Gov't, SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2011

3. Continental-scale patterns in benthic invertebrate diversity: insights from the MacroBen database

Author

Renaud, P.E., Webb, T.J., Bjørgesæter, A., Karakassis, I., Kedra, M., Kendall, M.A., Labrune, C., Lampadariou, N., Somerfield, P.J., Wlodarska-Kowalczuk, M., Vanden Berghe, E., Claus, S., Aleffi, I.F., Amouroux, J.M., Bryne, K.H., Cochrane, S.J., Dahle, S., Degraer, S., Denisenko, S.G., Deprez, T., Dounas, C., Fleischer, Dirk, Gil, J., Grémare, A., Janas, U., Mackie, A.S.Y., Palerud, R., Rumohr, Heye, Sardá, R., Speybroeck, J., Taboada, S., Van Hoey, G., Weslawski, J.M., Whomersley, P., Zettler, M.L., Renaud, P.E., Webb, T.J., Bjørgesæter, A., Karakassis, I., Kedra, M., Kendall, M.A., Labrune, C., Lampadariou, N., Somerfield, P.J., Wlodarska-Kowalczuk, M., Vanden Berghe, E., Claus, S., Aleffi, I.F., Amouroux, J.M., Bryne, K.H., Cochrane, S.J., Dahle, S., Degraer, S., Denisenko, S.G., Deprez, T., Dounas, C., Fleischer, Dirk, Gil, J., Grémare, A., Janas, U., Mackie, A.S.Y., Palerud, R., Rumohr, Heye, Sardá, R., Speybroeck, J., Taboada, S., Van Hoey, G., Weslawski, J.M., Whomersley, P., and Zettler, M.L.

Published
2009
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4. Continental-scale patterns in benthic invertebrate diversity: insights from the MacroBen database

Author

Renaud, P.E., Webb, T.J., Bjørgesæter, A., Karakassis, I., Kedra, M., Kendall, M.A., Labrune, C., Lampadariou, N., Somerfield, P.J., Wlodarska-Kowalczuk, M., Vanden Berghe, E., Claus, S., Aleffi, I.F., Amouroux, J.M., Bryne, K.H., Cochrane, S.J., Dahle, S., Degraer, S., Denisenko, S.G., Deprez, T., Dounas, C., Fleischer, Dirk, Gil, J., Grémare, A., Janas, U., Mackie, A.S.Y., Palerud, R., Rumohr, Heye, Sardá, R., Speybroeck, J., Taboada, S., Van Hoey, G., Weslawski, J.M., Whomersley, P., Zettler, M.L., Renaud, P.E., Webb, T.J., Bjørgesæter, A., Karakassis, I., Kedra, M., Kendall, M.A., Labrune, C., Lampadariou, N., Somerfield, P.J., Wlodarska-Kowalczuk, M., Vanden Berghe, E., Claus, S., Aleffi, I.F., Amouroux, J.M., Bryne, K.H., Cochrane, S.J., Dahle, S., Degraer, S., Denisenko, S.G., Deprez, T., Dounas, C., Fleischer, Dirk, Gil, J., Grémare, A., Janas, U., Mackie, A.S.Y., Palerud, R., Rumohr, Heye, Sardá, R., Speybroeck, J., Taboada, S., Van Hoey, G., Weslawski, J.M., Whomersley, P., and Zettler, M.L.

Abstract

Latitudinal clines in species diversity in limnic and terrestrial habitats have been noted for well over a century and are consistent across many taxonomic groups. However, studies in marine systems over the past 2 to 3 decades have yielded equivocal results. We conducted initial analyses of the MarBEF (EU Network of Excellence for Marine Biodiversity and Ecosystem Function) database to test for trends in local and regional diversity over the latitudinal extent of European continental-shelf waters (36° to 81°N). Soft-sediment benthic macrofauna exhibit little evidence of a latitudinal cline in local (α-) diversity measures. Relationships with water depth were relatively strong and complex. Statistically significant latitudinal trends were small and positive, suggesting a modest increase in diversity with latitude once water-depth covariates were removed. These results are consistent regardless of whether subsets of the database were used, replicates were pooled, or component taxonomical groups were evaluated separately. Local and regional diversity measures were significantly and positively correlated. Scientific cooperation through data-sharing is a powerful tool with which to address fundamental ecological and evolutionary questions relating to large-scale patterns and processes.

Published
2009

5. Marine Biodiversity and Ecosystem Functioning

Author

Heip, C., Hummel, H., van Avesaath, P., Appeltans, W., Arvanitidis, C., Aspden, R., Austen, M., Boero, F., Bouma, T. J., Boxshall, G., Buchholz, Friedrich, Crowe, T., Delaney, A., Deprez, T., Emblow, C., Feral, J. P., Gasol, J. M., Gooday, A., Harder, J., Ianora, A., Kraberg, Alexandra, Mackenzie, B., Ojaveer, H., Paterson, D., Rumohr, H., Schiedek, D., Sokolowski, A., Somerfield, P., Sousa Pinto, I., Vincx, M., Weslawski, J., Nash, R., Heip, C., Hummel, H., van Avesaath, P., Appeltans, W., Arvanitidis, C., Aspden, R., Austen, M., Boero, F., Bouma, T. J., Boxshall, G., Buchholz, Friedrich, Crowe, T., Delaney, A., Deprez, T., Emblow, C., Feral, J. P., Gasol, J. M., Gooday, A., Harder, J., Ianora, A., Kraberg, Alexandra, Mackenzie, B., Ojaveer, H., Paterson, D., Rumohr, H., Schiedek, D., Sokolowski, A., Somerfield, P., Sousa Pinto, I., Vincx, M., Weslawski, J., and Nash, R.

Published
2009

6. Marine Biodiversity and Ecosystem Functioning

Author

Heip, C., Hummel, H., van Avesaath, P., Appeltans, W., Arvanitidis, C., Aspden, R., Austen, M., Boero, F., Bouma, T. J., Boxshall, G., Buchholz, Friedrich, Crowe, T., Delaney, A., Deprez, T., Emblow, C., Feral, J. P., Gasol, J. M., Gooday, A., Harder, J., Ianora, A., Kraberg, Alexandra, Mackenzie, B., Ojaveer, H., Paterson, D., Rumohr, H., Schiedek, D., Sokolowski, A., Somerfield, P., Sousa Pinto, I., Vincx, M., Weslawski, J., Nash, R., Heip, C., Hummel, H., van Avesaath, P., Appeltans, W., Arvanitidis, C., Aspden, R., Austen, M., Boero, F., Bouma, T. J., Boxshall, G., Buchholz, Friedrich, Crowe, T., Delaney, A., Deprez, T., Emblow, C., Feral, J. P., Gasol, J. M., Gooday, A., Harder, J., Ianora, A., Kraberg, Alexandra, Mackenzie, B., Ojaveer, H., Paterson, D., Rumohr, H., Schiedek, D., Sokolowski, A., Somerfield, P., Sousa Pinto, I., Vincx, M., Weslawski, J., and Nash, R.

Published
2009

7. Marine Biodiversity and Ecosystem Functioning

Author

Heip, C., Hummel, H., van Avesaath, P., Appeltans, W., Arvanitidis, C., Aspden, R., Austenfeld, Marcel, Boero, F., Bouma, T.J., Boxshall, G., Buchholz, F., Crowe, T., Delaney, A., Deprez, T., Emblow, C., Feral, J.P., Gasol, J.M., Gooday, A., Harder, J., Ianora, A., Kraberg, A., Mackenzie, B., Ojaveer, H., Paterson, D., Rumohr, Heye, Schiedek, D., Sokolowski, A., Somerfield, P., Sousa Pinto, I., Vincx, M., Węsławski, J.M., Nash, R., Heip, C., Hummel, H., van Avesaath, P., Appeltans, W., Arvanitidis, C., Aspden, R., Austenfeld, Marcel, Boero, F., Bouma, T.J., Boxshall, G., Buchholz, F., Crowe, T., Delaney, A., Deprez, T., Emblow, C., Feral, J.P., Gasol, J.M., Gooday, A., Harder, J., Ianora, A., Kraberg, A., Mackenzie, B., Ojaveer, H., Paterson, D., Rumohr, Heye, Schiedek, D., Sokolowski, A., Somerfield, P., Sousa Pinto, I., Vincx, M., Węsławski, J.M., and Nash, R.

Published
2009

8. Marine Biodiversity and Ecosystem Functioning

Author

Heip, C., Hummel, H., van Avesaath, P., Appeltans, W., Arvanitidis, C., Aspden, R., Austenfeld, Marcel, Boero, F., Bouma, T.J., Boxshall, G., Buchholz, F., Crowe, T., Delaney, A., Deprez, T., Emblow, C., Feral, J.P., Gasol, J.M., Gooday, A., Harder, J., Ianora, A., Kraberg, A., Mackenzie, B., Ojaveer, H., Paterson, D., Rumohr, Heye, Schiedek, D., Sokolowski, A., Somerfield, P., Sousa Pinto, I., Vincx, M., Węsławski, J.M., Nash, R., Heip, C., Hummel, H., van Avesaath, P., Appeltans, W., Arvanitidis, C., Aspden, R., Austenfeld, Marcel, Boero, F., Bouma, T.J., Boxshall, G., Buchholz, F., Crowe, T., Delaney, A., Deprez, T., Emblow, C., Feral, J.P., Gasol, J.M., Gooday, A., Harder, J., Ianora, A., Kraberg, A., Mackenzie, B., Ojaveer, H., Paterson, D., Rumohr, Heye, Schiedek, D., Sokolowski, A., Somerfield, P., Sousa Pinto, I., Vincx, M., Węsławski, J.M., and Nash, R.

Published
2009

9. Marine Biodiversity and Ecosystem Functioning

Author

Heip, C., Hummel, H., van Avesaath, P., Appeltans, W., Arvanitidis, C., Aspden, R., Austenfeld, Marcel, Boero, F., Bouma, T.J., Boxshall, G., Buchholz, F., Crowe, T., Delaney, A., Deprez, T., Emblow, C., Feral, J.P., Gasol, J.M., Gooday, A., Harder, J., Ianora, A., Kraberg, A., Mackenzie, B., Ojaveer, H., Paterson, D., Rumohr, Heye, Schiedek, D., Sokolowski, A., Somerfield, P., Sousa Pinto, I., Vincx, M., Węsławski, J.M., Nash, R., Heip, C., Hummel, H., van Avesaath, P., Appeltans, W., Arvanitidis, C., Aspden, R., Austenfeld, Marcel, Boero, F., Bouma, T.J., Boxshall, G., Buchholz, F., Crowe, T., Delaney, A., Deprez, T., Emblow, C., Feral, J.P., Gasol, J.M., Gooday, A., Harder, J., Ianora, A., Kraberg, A., Mackenzie, B., Ojaveer, H., Paterson, D., Rumohr, Heye, Schiedek, D., Sokolowski, A., Somerfield, P., Sousa Pinto, I., Vincx, M., Węsławski, J.M., and Nash, R.

Published
2009

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