1. Non-mental diseases associated with ADHD across the lifespan : Fidgety Philipp and Pippi Longstocking at risk of multimorbidity?
- Author
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Kittel-Schneider, Sarah, Arteaga-Henriquez, Gara, Vasquez, Alejandro Arias, Asherson, Phil, Banaschewski, Tobias, Brikell, Isabell, Buitelaar, Jan, Cormand, Bru, Faraone, Stephen V., Freitag, Christine M., Ginsberg, Ylva, Haavik, Jan, Hartman, Catharina A., Kuntsi, Jonna, Larsson, Henrik, Matura, Silke, McNeill, Rhiannon V., Antoni Ramos-Quiroga, J., Ribases, Marta, Romanos, Marcel, Vainieri, Isabella, Franke, Barbara, Reif, Andreas, Kittel-Schneider, Sarah, Arteaga-Henriquez, Gara, Vasquez, Alejandro Arias, Asherson, Phil, Banaschewski, Tobias, Brikell, Isabell, Buitelaar, Jan, Cormand, Bru, Faraone, Stephen V., Freitag, Christine M., Ginsberg, Ylva, Haavik, Jan, Hartman, Catharina A., Kuntsi, Jonna, Larsson, Henrik, Matura, Silke, McNeill, Rhiannon V., Antoni Ramos-Quiroga, J., Ribases, Marta, Romanos, Marcel, Vainieri, Isabella, Franke, Barbara, and Reif, Andreas
- Abstract
Several non-mental diseases seem to be associated with an increased risk of ADHD and ADHD seems to be associated with increased risk for non-mental diseases. The underlying trajectories leading to such brain-body co-occurrences are often unclear - are there direct causal relationships from one disorder to the other, or does the sharing of genetic and/or environmental risk factors lead to their occurring together more frequently or both? Our goal with this narrative review was to provide a conceptual synthesis of the associations between ADHD and non-mental disease across the lifespan. We discuss potential shared pathologic mechanisms and genetic background and treatments in co-occurring diseases. For those co-occurrences for which published studies with sufficient sample sizes exist, meta-analyses have been published by others and we discuss those in detail. We conclude that non-mental diseases are common in ADHD and vice versa and add to the disease burden of the patient across the lifespan. Insufficient attention to such co-occurring conditions may result in missed diagnoses and suboptimal treatment in the affected individuals., Funding agencies:Deutscher Akademischer Austausch Dienst (DAAD) European Commission 91690211 Lundbeck Foundation iPSYCH grant R102-A9118 R155-2014-1724 R248-2017-2003 Federal Ministry of Education & Research (BMBF)Spanish Government SAF2015-68341-R RTI2018-100968-B-I00 Agencia de Gestio D'Ajuts Universitaris de Recerca Agaur (AGAUR) Generalitat de Catalunya 2017-SGR-738 Innovative Medicine Initiative (IMI2)-Call 2 853966Instituto de Salud Carlos III CP09/ 00119 CPII15/00023 Instituto de Salud Carlos III PI17/00289Agencia de Gestio D'Ajuts Universitaris de Recerca Agaur (AGAUR)Generalitat de Catalunya General Electric 2017SGR1461Stiftelsen Kristian Gerhard Jebsen SKGJ MED-02Regional Health Authority of Western Norway F-10146
- Published
- 2022
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