35 results on '"FOREIGN body reaction"'
Search Results
2. Commentary: A lymph node mediastinal foreign body reaction mimicking nodal metastasis: a case series
- Author
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Franceschini, Gianluca, Franceschini G. (ORCID:0000-0002-2950-3395), Franceschini, Gianluca, and Franceschini G. (ORCID:0000-0002-2950-3395)
- Abstract
No abstract available
- Published
- 2023
3. Foreign body reaction to polyacrylamide filler (Aquafilling (R)) injected nine years previously: A complication of SARS-CoV-2 infection or merely a coincidence?
- Author
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İncel Uysal, Pınar, Uysal, Ahmet Çagrı, Börcek, Pelin, Özkan, Burak, Savran, Süleyman, İncel Uysal, Pınar, Uysal, Ahmet Çagrı, Börcek, Pelin, Özkan, Burak, and Savran, Süleyman
- Published
- 2023
4. Foreign body reaction to polyacrylamide filler (Aquafilling (R)) injected nine years previously: A complication of SARS-CoV-2 infection or merely a coincidence?
- Author
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Uysal, Ahmet Çagrı, Börcek, Pelin, Savran, Süleyman, İncel Uysal, Pınar, Özkan, Burak, Uysal, Ahmet Çagrı, Börcek, Pelin, Savran, Süleyman, İncel Uysal, Pınar, and Özkan, Burak
- Published
- 2023
5. Nano-Roughness-Mediated Macrophage Polarization for Desired Host Immune Response
- Author
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Universitat Rovira i Virgili, Dabare, PRL; Bachhuka, A; Quek, JY; Marsal, LF; Hayball, J; Vasilev, K, Universitat Rovira i Virgili, and Dabare, PRL; Bachhuka, A; Quek, JY; Marsal, LF; Hayball, J; Vasilev, K
- Abstract
Macrophage polarization is a significant event in the host immune response, which can be modulated by modifying the surface of a biomaterial. Previous studies have demonstrated the modulation of macrophage polarization using different surface features; however, none of these studies reflect the effect of surface properties on unstimulated macrophage polarization for a prolonged period. To better understand the impact of surface features, in this work differentiated THP-1 cells are employed to control macrophage polarization on nano-rough surfaces for a duration of 7 days. Model nano-rough substrates are fabricated by immobilizing gold nanoparticles (AuNPs) of predetermined sizes (16, 38, 68 nm) on a 2-methyl-2-oxazoline thin film, followed by tailoring the outermost surface chemistry. All modified surfaces support high levels of cell adhesion and proliferation. Over time, the expression of pro-inflammatory cytokines decreases, whereas the expression of anti-inflammatory cytokines increases on all modified surfaces. Similarly, pro-inflammatory interleukin (IL)-1 & beta; gene expression is downregulated, and anti-inflammatory IL-10-gene expression is upregulated, regardless of the surface roughness. Analysis of cell morphology reveals that the predominant cell type on the modified surfaces exhibits M2 anti-inflammatory phenotype. Herein, how surface features can modulate macrophage responses over an extended period is highlighted, offering insights for the development of future biomaterial implants.
- Published
- 2023
6. Modified foreign body reaction to silicone imbedded in subcutaneous tissues by different mouse systemic immune conditions
- Author
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Yamakawa, Tomohiro, Ichii, Osamu, Nakamura, Teppei, Namba, Takashi, Elewa, Yaser Hosny Ali, Masum, Md. Abdul, Otani, Yuki, Nishimura, Takanori, Kon, Yasuhiro, Yamakawa, Tomohiro, Ichii, Osamu, Nakamura, Teppei, Namba, Takashi, Elewa, Yaser Hosny Ali, Masum, Md. Abdul, Otani, Yuki, Nishimura, Takanori, and Kon, Yasuhiro
- Abstract
Foreign body reaction (FBR) causes unexpected adverse effects due to implanted materials in humans and animals. Inflammation and subsequent fibrosis during FBR seems to be affected by recipient immunity, such as the balance of T helper (Th) response that has the potential to regulate FBR-related macrophage function. Here, the immunological effects of FBR on subcutaneously imbedded silicone tubes (ST) at 8 weeks were investigated histologically by comparing Th1-biased C57BL/6N, Th2-biased MRL/MpJ, and autoimmune disease-prone MRL/MpJ-Fas(lpr/lpr). Tissue surrounding ST (TSS) was analyzed at day (D) 7 and 14 (reaction phase) or D35 (stability phase) after surgery. In all strains, the TSS was composed of a thin layer (TL) containing fibrous tissues and loose connective tissues formed outside the TL. Few lymphocytes and mast cells, several neutrophils, and numerous macrophages infiltrated the TSS. Active vascularization was observed at D14 in all strains. For the examined indices, M1-type macrophage density in the TSS of C57BL/6N mice was significantly higher at D14 compared to other strains. No significant strain difference relating to M2-type macrophages was detected, suggesting the effects of Th1-biased immunity on FBR-related inflammation. Collagen fibers in the TSS increased in density and became stable with age in all strains. In particular, MRL/MpJ-Fas(lpr/lpr) showed progressive fibrotic features. Serum autoantibody levels in MRL/MpJ-Fas(lpr/lpr) mice were inversely correlated with M1-type macrophage density. These data from MRL/MpJ-Fas(lpr/lpr) mice suggested modifications of FBR-related inflammation and fibrosis by autoimmune abnormalities. The results provide crucial insights into the pathological modification of FBR by recipient immunity and emphasize its clinicopathological importance in humans and animals.
- Published
- 2022
7. Extrusion of suture and granuloma formation from a neck thread lift
- Author
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Choi, Ellie, Choi, Ellie, Cheong, Ee Cherk, Leow, Yung Hian, Choi, Ellie, Choi, Ellie, Cheong, Ee Cherk, and Leow, Yung Hian
- Published
- 2021
8. Extrusion of suture and granuloma formation from a neck thread lift
- Author
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Choi, Ellie, Choi, Ellie, Cheong, Ee Cherk, Leow, Yung Hian, Choi, Ellie, Choi, Ellie, Cheong, Ee Cherk, and Leow, Yung Hian
- Published
- 2021
9. Post-operative imaging surveillance of breast cancer patients status post lumpectomy with BioZorb implant placement
- Author
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Ram, Shruthi, Dietsche, Eric, Ram, Shruthi, and Dietsche, Eric
- Abstract
The evolving nature of newer surgical techniques and devices adds to the challenge of interpreting breast imaging in the post lumpectomy setting. The BioZorb surgical marker placed at lumpectomy sites for post-operative radiation targeting has its own distinct imaging appearance on each modality. Determining the expected follow-up imaging findings unique to this relatively new device is an ongoing endeavor with literature currently lacking on this topic. The following series of cases of post BioZorb breast surveillance are the first reported in the literature to provide examples of developing asymmetries and new or enlarging masses adjacent to the BioZorb site along with the final pathologic diagnosis for each case. Pathology findings range from fat necrosis and foreign body reaction to recurrent disease.
- Published
- 2021
10. Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone
- Author
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Oe, Sao, Masum, Md. Abdul, 1000060547769, Ichii, Osamu, Nishimura, Takanori, Nakamura, Teppei, Namba, Takashi, Otani, Yuki, Nakayama, Yasuhide, Elewa, Yaser Hosny Ali, 1000010178402, Kon, Yasuhiro, Oe, Sao, Masum, Md. Abdul, 1000060547769, Ichii, Osamu, Nishimura, Takanori, Nakamura, Teppei, Namba, Takashi, Otani, Yuki, Nakayama, Yasuhide, Elewa, Yaser Hosny Ali, 1000010178402, and Kon, Yasuhiro
- Abstract
We investigated spatiotemporal changes in host tissues during foreign body reactions. Silicone tube was subcutaneously embedded into ICR mice, and tissue surrounding silicone (TSS) was observed at 2, 7, 14, 21, 28, 43, and 70 days (D) postsurgery. The thin layer (TL) and loose connective tissues (LCTs) (inside and outside the TSS) developed until D21 and densified afterward. Neutrophils infiltrated the TSS until D14 and formed neutrophil extracellular traps (NETs) in the TL during D7-21. In the LCTs, mast cell counts increased until D21, and macrophage numbers peaked at D14. Several macrophages showed LYVE-1 expression, supporting a tissue-remodeling role. Developmental indices of collagen fibers (CFs) and reticular fibers (RFs) increased during D2-21. NETs, but not neutrophils, were detected after D28. Mast cell numbers peaked at D43 and were maintained until D70. Myofibroblasts consistently localized to the TL from D14. During D21-28, the area of connective tissue (CNT), and CFs and RFs decreased and increased, respectively, and both remained constant during D28-70. The CF density remained constant from D21 and increased at D70. Thus, TSS showed two phases: inflammation and CNT development (D2-21), and inflammation convergence and CNT stabilization (D28-70). These results provide insights into foreign body reactions in clinical cases.
- Published
- 2020
11. The effect of diclofenac sodium-loaded poly(lactide-co-glycolide) rods on bone formation and inflammation:a histological and histomorphometric study in the femora of rats
- Author
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Reich, K. M. (Karoline M.), Viitanen, P. (Petrus), Apu, E. H. (Ehsanul Hoque), Tangl, S. (Stefan), Reich, K. M. (Karoline M.), Viitanen, P. (Petrus), Apu, E. H. (Ehsanul Hoque), and Tangl, S. (Stefan)
- Abstract
Implants made of poly(lactide-co-glycolide) (PLGA) are biodegradable and frequently provoke foreign body reactions (FBR) in the host tissue. In order to modulate the inflammatory response of the host tissue, PLGA implants can be loaded with anti-inflammatory drugs. The aim of this study was to analyze the impact of PLGA 80/20 rods loaded with the diclofenac sodium (DS) on local tissue reactions in the femur of rats. Special emphasis was put on bone regeneration and the presence of multinucleated giant cells (MGCs) associated with FBR. PLGA 80/20 alone and PLGA 80/20 combined with DS was extruded into rods. PLGA rods loaded with DS (PLGA+DS) were implanted into the femora of 18 rats. Eighteen control rats received unloaded PLGA rods. The follow-up period was of 3, 6 and 12 weeks. Each group comprised of six rats. Peri-implant tissue reactions were histologically and histomorphometrically evaluated. The implantation of PLGA and PLGA+DS8 rods induced the formation of a layer of newly formed bone islands parallel to the contour of the implants. PLGA+DS rods tended to reduce the presence of multi-nucleated giant cells (MGCs) at the implant surface. Although it is known that the systemic administration of DS is associated with compromised bone healing, the local release of DS via PLGA rods did not have negative effects on bone regeneration in the femora of rats throughout 12 weeks.
- Published
- 2020
12. Spatiotemporal histological changes observed in mouse subcutaneous tissues during the foreign body reaction to silicone
- Author
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Oe, Sao, Masum, Md. Abdul, Ichii, Osamu, Nishimura, Takanori, Nakamura, Teppei, Namba, Takashi, Otani, Yuki, Nakayama, Yasuhide, Elewa, Yaser Hosny Ali, Kon, Yasuhiro, Oe, Sao, Masum, Md. Abdul, Ichii, Osamu, Nishimura, Takanori, Nakamura, Teppei, Namba, Takashi, Otani, Yuki, Nakayama, Yasuhide, Elewa, Yaser Hosny Ali, and Kon, Yasuhiro
- Abstract
We investigated spatiotemporal changes in host tissues during foreign body reactions. Silicone tube was subcutaneously embedded into ICR mice, and tissue surrounding silicone (TSS) was observed at 2, 7, 14, 21, 28, 43, and 70 days (D) postsurgery. The thin layer (TL) and loose connective tissues (LCTs) (inside and outside the TSS) developed until D21 and densified afterward. Neutrophils infiltrated the TSS until D14 and formed neutrophil extracellular traps (NETs) in the TL during D7-21. In the LCTs, mast cell counts increased until D21, and macrophage numbers peaked at D14. Several macrophages showed LYVE-1 expression, supporting a tissue-remodeling role. Developmental indices of collagen fibers (CFs) and reticular fibers (RFs) increased during D2-21. NETs, but not neutrophils, were detected after D28. Mast cell numbers peaked at D43 and were maintained until D70. Myofibroblasts consistently localized to the TL from D14. During D21-28, the area of connective tissue (CNT), and CFs and RFs decreased and increased, respectively, and both remained constant during D28-70. The CF density remained constant from D21 and increased at D70. Thus, TSS showed two phases: inflammation and CNT development (D2-21), and inflammation convergence and CNT stabilization (D28-70). These results provide insights into foreign body reactions in clinical cases.
- Published
- 2020
13. Comparison of two prototypes of a magnetically adjustable glaucoma implant in rabbits
- Author
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Schwerk, Birthe, Harder, Lisa, Windhövel, Claudia, Hewicker-Trautwein, Marion, Wagner, Anna, Bach, Jan-Peter, Voigt, Lena Carolin, Hinze, Ulf, Chichkov, Boris, Haferkamp, Heinz, Lubatschowski, Holger, Nikolic, Stephan, Nolte, Ingo, Schwerk, Birthe, Harder, Lisa, Windhövel, Claudia, Hewicker-Trautwein, Marion, Wagner, Anna, Bach, Jan-Peter, Voigt, Lena Carolin, Hinze, Ulf, Chichkov, Boris, Haferkamp, Heinz, Lubatschowski, Holger, Nikolic, Stephan, and Nolte, Ingo
- Abstract
Glaucoma drainage devices are used in surgical glaucoma therapy. Success of controlling the intraocular pressure is limited due to fibrous implant encapsulation and fibrin coating on the implant which lead to drainage obstructions. An innovative implant with a magnetically adjustable valve was developed. The valve opening of the implant should eliminate inflammatory products from the outflow area and affect fibrous tissue formation to achieve a sufficient long-term aqueous humour outflow. Lifting of this valve should disturb cell adhesion by exerting mechanical forces. Before testing this hypothesis, the flow characteristics of glaucoma drainage devices, especially the outflow resistance by regular IOP, should be considered in a pilot study, as they are important in preventing too low postoperative intraocular pressure known as ocular hypotony. Therefore, two prototypes of the innovative implant differing in their valve area design were examined regarding their flow characteristics in a limited animal experiment lasting two weeks. Ten healthy New Zealand White rabbits were divided into two groups (A & B) with different implanted prototypes. Daily, tonometry and direct ophthalmoscopy were performed to assess the intraocular pressure and the inflammatory reaction of the eye. After two weeks, the rabbits were euthanised to evaluate the initially histological inflammatory reaction to the implant. In group A, one case of hypotony emerged. When considering the entire observation period, a highly statistically significant difference between the intraocular pressure in the operated eye and that in the control eye was detected in group A (p < 0.0001) in contrast to group B (p = 0.0063). The postoperative inflammatory signs decreased within two weeks. Histologically, a typical but low level foreign body reaction with macrophages and lymphocytes as well as mild to moderate fibrosis was seen after the short experimental period. Based on our tonometric results, prototype B seems
- Published
- 2019
14. Bone Immune Response to Materials, Part I : Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia
- Author
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Trindade, Ricardo, Albrektsson, Tomas, Galli, Silvia, Prgomet, Zdenka, Tengvall, Pentti, Wennerberg, Ann, Trindade, Ricardo, Albrektsson, Tomas, Galli, Silvia, Prgomet, Zdenka, Tengvall, Pentti, and Wennerberg, Ann
- Abstract
Bone anchored biomaterials have become an indispensable solution for the restoration of lost dental elements and for skeletal joint replacements. However, a thorough understanding is still lacking in terms of the biological mechanisms leading to osseointegration and its contrast, unwanted peri-implant bone loss. We have previously hypothesized on the participation of immune mechanisms in such processes, and later demonstrated enhanced bone immune activation up to 4 weeks around titanium implants. The current experimental study explored and compared in a rabbit tibia model after 10 days of healing time, the bone inflammation/immunological reaction at mRNA level towards titanium, polyether ether ketone (PEEK) and copper compared to a Sham control. Samples from the test and control sites were, after a healing period, processed for gene expression analysis (polymerase chain reaction, (qPCR)) and decalcified histology tissue analysis. All materials displayed immune activation and suppression of bone resorption, when compared to sham. The M1 (inflammatory)/M2 (reparative) -macrophage phenotype balance was correlated to the proximity and volume of bone growth at the implant vicinity, with titanium demonstrating a M2-phenotype at 10 days, whereas copper and PEEK were still dealing with a mixed M1- and M2-phenotype environment. Titanium was the only material showing adequate bone growth and proximity inside the implant threads. There was a consistent upregulation of (T-cell surface glycoprotein CD4) CD4 and downregulation of (T-cell transmembrane glycoprotein CD8) CD8, indicating a CD4-lymphocyte phenotype driven reaction around all materials at 10 days.
- Published
- 2018
- Full Text
- View/download PDF
15. Bone Immune Response to Materials, Part I : Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia
- Author
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Trindade, Ricardo, Albrektsson, Tomas, Galli, Silvia, Prgomet, Zdenka, Tengvall, Pentti, Wennerberg, Ann, Trindade, Ricardo, Albrektsson, Tomas, Galli, Silvia, Prgomet, Zdenka, Tengvall, Pentti, and Wennerberg, Ann
- Abstract
Bone anchored biomaterials have become an indispensable solution for the restoration of lost dental elements and for skeletal joint replacements. However, a thorough understanding is still lacking in terms of the biological mechanisms leading to osseointegration and its contrast, unwanted peri-implant bone loss. We have previously hypothesized on the participation of immune mechanisms in such processes, and later demonstrated enhanced bone immune activation up to 4 weeks around titanium implants. The current experimental study explored and compared in a rabbit tibia model after 10 days of healing time, the bone inflammation/immunological reaction at mRNA level towards titanium, polyether ether ketone (PEEK) and copper compared to a Sham control. Samples from the test and control sites were, after a healing period, processed for gene expression analysis (polymerase chain reaction, (qPCR)) and decalcified histology tissue analysis. All materials displayed immune activation and suppression of bone resorption, when compared to sham. The M1 (inflammatory)/M2 (reparative) -macrophage phenotype balance was correlated to the proximity and volume of bone growth at the implant vicinity, with titanium demonstrating a M2-phenotype at 10 days, whereas copper and PEEK were still dealing with a mixed M1- and M2-phenotype environment. Titanium was the only material showing adequate bone growth and proximity inside the implant threads. There was a consistent upregulation of (T-cell surface glycoprotein CD4) CD4 and downregulation of (T-cell transmembrane glycoprotein CD8) CD8, indicating a CD4-lymphocyte phenotype driven reaction around all materials at 10 days.
- Published
- 2018
- Full Text
- View/download PDF
16. Suture wear particles cause a significant inflammatory response in a murine synovial airpouch model
- Author
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Lovric, Vedran, Goldberg, Michael J., Heuberer, Philipp R., Oliver, Rema A., Stone, Dana, Laky, Brenda, Page, Richard S., Walsh, William R., Lovric, Vedran, Goldberg, Michael J., Heuberer, Philipp R., Oliver, Rema A., Stone, Dana, Laky, Brenda, Page, Richard S., and Walsh, William R.
- Abstract
BACKGROUND: Commonly used contemporary orthopaedic sutures have been identified as a potential causative factor in the development of post-arthroscopic glenohumeral chondrolysis. Currently, little is known about the body's immune response to these materials. The aim of this study was to examine the biological response of synovial tissue to three commonly used orthopaedic sutures, using a murine airpouch model. METHODS: Fifty rats were used in this study (ten per group). An airpouch was created in each rat, and test materials were implanted. Test materials consisted of an intact polyethylene terephthalate suture with a polybutilate coating (suture A), an intact polyethylene suture braided around a central polydiaxannone core (suture B), an intact polyethylene/polyester cobraid suture with a silicone coating (suture C), and particles of suture C (particles C). Rats were sacrificed at 1 or 4 weeks following implantation. Histological (multinucleated giant cell count) and immunohistochemical (expression of matrix metalloproteinases MMP-1,-2,-3,-9,-13) markers of inflammation were examined. RESULTS: Multinucleated giant cells were present in all specimens containing suture material but not in the control specimens. No significant differences were found in the number of giant cells between the intact suture groups at either time point. Significantly higher numbers of giant cells were noted in the particles C group compared to the intact suture C group at both time points (p = 0.021 at 1 week, p = 0.003 at 4 weeks). Quantitative analysis of immunohistochemical staining expression at 4 weeks showed that significantly more MMP (-1,-2,-9,-13) was expressed in the particles C group than the intact suture C group (p = 0.024, p = 0.009, p = 0.002, and p = 0.007 for MMP-1, MMP-2, MMP-9, and MMP-13, respectively). No significant difference was seen in the expression of MMP-3 (p&
- Published
- 2018
17. Time course study of long‐term biocompatibility and foreign body reaction to intraneural polyimide‐based implants
- Author
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European Commission, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Ministerio de Economía, Industria y Competitividad (España), Oliva, Natàlia de la [0000-0002-1263-2705], Navarro, Xavier [0000-0001-9849-902X], Valle, Jaume del [0000-0002-6703-8244], Oliva, Natàlia de la, Navarro, Xavier, Valle, Jaume del, European Commission, Instituto de Salud Carlos III, Ministerio de Economía y Competitividad (España), Ministerio de Economía, Industria y Competitividad (España), Oliva, Natàlia de la [0000-0002-1263-2705], Navarro, Xavier [0000-0001-9849-902X], Valle, Jaume del [0000-0002-6703-8244], Oliva, Natàlia de la, Navarro, Xavier, and Valle, Jaume del
- Abstract
The foreign body reaction (FBR) against an implanted device is characterized by the formation of a fibrotic tissue around the implant. In the case of interfaces for peripheral nerves, used to stimulate specific group of axons and to record different nerve signals, the FBR induces a matrix deposition around the implant creating a physical separation between nerve fibers and the interface that may reduce its functionality over time. In order to understand how the FBR to intraneural interfaces evolves, polyimide non-functional devices were implanted in rat peripheral nerve. Functional tests (electrophysiological, pain and locomotion) and histological evaluation demonstrated that implanted devices did not cause any alteration in nerve function, in myelinated axons or in nerve architecture. The inflammatory response due to the surgical implantation decreased after 2 weeks. In contrast, inflammation was higher and more prolonged in the device implanted nerves with a peak after 2 weeks. With regard to tissue deposition, a tissue capsule appeared soon around the devices, acquiring maximal thickness at 2 weeks and being remodeled subsequently. Immunohistochemical analysis revealed two different cell types implicated in the FBR in the nerve: macrophages as the first cells in contact with the interface and fibroblasts that appear later at the edge of the capsule. Our results describe how the FBR against a polyimide implant in the peripheral nerve occurs and which are the main cellular players. Increasing knowledge of these responses will help to improve strategies to decrease the FBR against intraneural implants and to extend their usability.
- Published
- 2018
18. Chronically Implanted Intracranial Electrodes: Tissue Reaction and Electrical Changes.
- Author
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Campbell, Andrew, Wu, Chengyuan, Campbell, Andrew, and Wu, Chengyuan
- Abstract
The brain-electrode interface is arguably one of the most important areas of study in neuroscience today. A stronger foundation in this topic will allow us to probe the architecture of the brain in unprecedented functional detail and augment our ability to intervene in disease states. Over many years, significant progress has been made in this field, but some obstacles have remained elusive-notably preventing glial encapsulation and electrode degradation. In this review, we discuss the tissue response to electrode implantation on acute and chronic timescales, the electrical changes that occur in electrode systems over time, and strategies that are being investigated in order to minimize the tissue response to implantation and maximize functional electrode longevity. We also highlight the current and future clinical applications and relevance of electrode technology.
- Published
- 2018
19. Osseointegration of Implants : A Biological and Clinical Overview
- Author
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Albrektsson, Tomas, Chrcanovic, Bruno, Jacobsson, Magnus, Wennerberg, Ann, Albrektsson, Tomas, Chrcanovic, Bruno, Jacobsson, Magnus, and Wennerberg, Ann
- Abstract
Osseointegration was discovered in 1962 and coined as a term in 1977. Original definitions implied direct contact between foreign materials and bone without any interposed soft tissue layers. Today, osseointegration is regarded to be a foreign body response to separate foreign elements from bone. A new definition of the term is suggested in this paper; “Osseointegration is a foreign body reaction where interfacial bone is formed as a defense reaction to shield off the implant from the tissues”. Excellent clinical results of osseointegrated implants have been reported from dentistry and Ear Nose Throat surgery, the latter with the indications of a stable anchorage of hearing aids or facial epistheses in cases of facial trauma. In Orthopaedic surgery a randomized controlled clinical trial has been undertaken demonstrating very good clinical results supported by positive radiostereo-photogrammetical data.
- Published
- 2017
20. Major Abdominal Surgical Complications : Innovative Approaches
- Author
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Hoeve-Boersema, G.S.A. (Simone) ter and Hoeve-Boersema, G.S.A. (Simone) ter
- Abstract
In this thesis the focus was on three major complications after abdominal surgery: incisional hernia (IH), prolonged postoperative ileus (PPOI), and colorectal anastomotic leakage (CAL). The results were summarized in three parts: _Part 1_ focused on prediction and detection of these surgical complications; _Part 2_ describes different methods to prevent complications; _Part 3_ analyzed also prevention of major surgical complications with a focus on patients at risk. Even anno 2017 it is still necessary to explore new strategies to prevent complications in abdominal surgery. Also with new surgical techniques, for example the use of staplers for colorectal anastomosis, prevention of CAL is still an issue. In addition, early detection of a complication is necessary to prevent from worse. This also requires more attention and research since detection of leakage is still mainly based on clinical observation and the experience of the surgeon. Research on more advanced technical and/ or digital solutions to objectively assess and quantify leakage and other complications is strongly needed. Therefore in this thesis the focus was to develop different strategies that may facilitate prevention, prediction, and diagnosis of different important abdominal surgical complications such as colorectal anastomotic leakage, postoperative ileus, incisional hernia, and infectious complications.
- Published
- 2017
21. Osseointegration of Implants : A Biological and Clinical Overview
- Author
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Albrektsson, Tomas, Chrcanovic, Bruno, Jacobsson, Magnus, Wennerberg, Ann, Albrektsson, Tomas, Chrcanovic, Bruno, Jacobsson, Magnus, and Wennerberg, Ann
- Abstract
Osseointegration was discovered in 1962 and coined as a term in 1977. Original definitions implied direct contact between foreign materials and bone without any interposed soft tissue layers. Today, osseointegration is regarded to be a foreign body response to separate foreign elements from bone. A new definition of the term is suggested in this paper; “Osseointegration is a foreign body reaction where interfacial bone is formed as a defense reaction to shield off the implant from the tissues”. Excellent clinical results of osseointegrated implants have been reported from dentistry and Ear Nose Throat surgery, the latter with the indications of a stable anchorage of hearing aids or facial epistheses in cases of facial trauma. In Orthopaedic surgery a randomized controlled clinical trial has been undertaken demonstrating very good clinical results supported by positive radiostereo-photogrammetical data.
- Published
- 2017
22. Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior.
- Author
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Levoe, S Nikki, Levoe, S Nikki, Flannery, Brenna M, Brignolo, Laurie, Imai, Denise M, Koehne, Amanda, Austin, Adam T, Bruun, Donald A, Tancredi, Daniel J, Lein, Pamela J, Levoe, S Nikki, Levoe, S Nikki, Flannery, Brenna M, Brignolo, Laurie, Imai, Denise M, Koehne, Amanda, Austin, Adam T, Bruun, Donald A, Tancredi, Daniel J, and Lein, Pamela J
- Abstract
Repeated subcutaneous (s.c.) injection is a common route of administration in chronic studies of neuroactive compounds. However, in a pilot study we noted a significant incidence of skin abnormalities in adult male Long-Evans rats receiving daily s.c. injections of peanut oil (1.0 ml/kg) in the subscapular region for 21 d. Histopathological analyses of the lesions were consistent with a foreign body reaction. Subsequent studies were conducted to determine factors that influenced the incidence or severity of skin abnormalities, and whether these adverse skin reactions influenced a specific neurobehavioral outcome. Rats injected daily for 21 d with food grade peanut oil had an earlier onset and greater incidence of skin abnormalities relative to rats receiving an equal volume (1.0 ml/kg/d) of reagent grade peanut oil or triglyceride of coconut oil. Skin abnormalities in animals injected daily with peanut oil were increased in animals housed on corncob versus paper bedding. Comparison of animals obtained from different barrier facilities exposed to the same injection paradigm (reagent grade peanut oil, 1.0 ml/kg/d s.c.) revealed significant differences in the severity of skin abnormalities. However, animals from different barrier facilities did not perform differently in a Pavlovian fear conditioning task. Collectively, these data suggest that environmental factors influence the incidence and severity of skin abnormalities following repeated s.c. injections, but that these adverse skin responses do not significantly influence performance in at least one test of learning and memory.
- Published
- 2014
23. Factors influencing adverse skin responses in rats receiving repeated subcutaneous injections and potential impact on neurobehavior.
- Author
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Levoe, S Nikki, Levoe, S Nikki, Flannery, Brenna M, Brignolo, Laurie, Imai, Denise M, Koehne, Amanda, Austin, Adam T, Bruun, Donald A, Tancredi, Daniel J, Lein, Pamela J, Levoe, S Nikki, Levoe, S Nikki, Flannery, Brenna M, Brignolo, Laurie, Imai, Denise M, Koehne, Amanda, Austin, Adam T, Bruun, Donald A, Tancredi, Daniel J, and Lein, Pamela J
- Abstract
Repeated subcutaneous (s.c.) injection is a common route of administration in chronic studies of neuroactive compounds. However, in a pilot study we noted a significant incidence of skin abnormalities in adult male Long-Evans rats receiving daily s.c. injections of peanut oil (1.0 ml/kg) in the subscapular region for 21 d. Histopathological analyses of the lesions were consistent with a foreign body reaction. Subsequent studies were conducted to determine factors that influenced the incidence or severity of skin abnormalities, and whether these adverse skin reactions influenced a specific neurobehavioral outcome. Rats injected daily for 21 d with food grade peanut oil had an earlier onset and greater incidence of skin abnormalities relative to rats receiving an equal volume (1.0 ml/kg/d) of reagent grade peanut oil or triglyceride of coconut oil. Skin abnormalities in animals injected daily with peanut oil were increased in animals housed on corncob versus paper bedding. Comparison of animals obtained from different barrier facilities exposed to the same injection paradigm (reagent grade peanut oil, 1.0 ml/kg/d s.c.) revealed significant differences in the severity of skin abnormalities. However, animals from different barrier facilities did not perform differently in a Pavlovian fear conditioning task. Collectively, these data suggest that environmental factors influence the incidence and severity of skin abnormalities following repeated s.c. injections, but that these adverse skin responses do not significantly influence performance in at least one test of learning and memory.
- Published
- 2014
24. Paraffinoma of lips and oral mucosa: Case report and brief review of the literature
- Author
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Friedrich, RE, Zustin, J, Friedrich, RE, and Zustin, J
- Abstract
Interstitial application of paraffin in plastic and reconstructive surgery is obsolete due to the development of permanent and extensive foreign body granulomas at the site of application. These granulomas can cause severe physical impairment and develop their own prognostic worth. Furthermore, the disperse oil droplets are not a locally stable suspension. Therefore, the desired aesthetic aspect can get lost in the course of a potential dislocation of the suspension. In addition, the interstitial confluence of non-resorbable droplets to larger oil drops causes palpable and sometimes visible indurations of the skin, the correlate of chronic inflammation. This case report describes the efforts undertaken to release the patient at least temporarily from her paraffin granulomas and to improve her appearance. The relevant literature is briefly discussed. Furthermore, we present some immunohistochemical findings to specify the foreign body reaction associated with paraffin injections into connective tissues., Die interstitielle Applikation von Paraffin ist in der plastischen und Wiederherstellungschirurgie obsolet, weil zu erwarten ist, dass am Ort der Applikation dauerhaft ausgedehnte Fremdkörpergranulome entstehen, die einen erheblichen Krankheitswert entwickeln können. Darüber hinaus sind die interstitiell eingebrachten, fein dispersen Öltröpfchen nicht ortsstabil. Der gewünschte ästhetische Effekt kann somit durch Verlagerungen des Gemisches verloren gehen. Zudem führt der Zusammenfluss nicht resorbierbaren Paraffins im Bindegewebe als Korrelat der chronischen Entzündungsreaktion zu den fühl- oder auch sichtbaren Verhärtungen des Integuments, die zum Krankheitswert der Fremdkörperinstillation wesentlich beitragen. Der Fallbericht beschreibt das Bemühen, angesichts einer ausgedehnten Injektion von Paraffin in die Lippen durch geeignete chirurgische Maßnahmen zumindest temporär das Erscheinungsbild zu harmonisieren. Die Literatur zum Thema wird kurz zusammengefasst. Darüber hinaus wird mit modernen immunhistochemischen Methoden die interstitielle Fremdkörperreaktion weiter spezifiziert.
- Published
- 2014
25. Outer electrospun polycaprolactone shell induces massive foreign body reaction and impairs axonal regeneration through 3D multichannel chitosan nerve guides
- Author
-
Duda, Sven, Dreyer, Lutz, Behrens, Peter, Wienecke, Soenke, Chakradeo, Tanmay, Glasmacher, Birgit, Haastert-Talini, Kirsten, Duda, Sven, Dreyer, Lutz, Behrens, Peter, Wienecke, Soenke, Chakradeo, Tanmay, Glasmacher, Birgit, and Haastert-Talini, Kirsten
- Abstract
We report on the performance of composite nerve grafts with an inner 3D multichannel porous chitosan core and an outer electrospun polycaprolactone shell. The inner chitosan core provided multiple guidance channels for regrowing axons. To analyze the in vivo properties of the bare chitosan cores, we separately implanted them into an epineural sheath. The effects of both graft types on structural and functional regeneration across a 10 mm rat sciatic nerve gap were compared to autologous nerve transplantation (ANT). The mechanical biomaterial properties and the immunological impact of the grafts were assessed with histological techniques before and after transplantation in vivo. Furthermore during a 13-week examination period functional tests and electrophysiological recordings were performed and supplemented by nerve morphometry. The sheathing of the chitosan core with a polycaprolactone shell induced massive foreign body reaction and impairment of nerve regeneration. Although the isolated novel chitosan core did allow regeneration of axons in a similar size distribution as the ANT, the ANT was superior in terms of functional regeneration. We conclude that an outer polycaprolactone shell should not be used for the purpose of bioartificial nerve grafting, while 3D multichannel porous chitosan cores could be candidate scaffolds for structured nerve grafts.
- Published
- 2014
26. Relations between cochlear histopathology and hearing loss in experimental cochlear implantation.
- Author
-
Richardson R., Souter M.A., Chang A., Marovic P., O'Leary J.S., Eastwood H., O'Leary S.J., Monksfield P., Kel G., Connolly T., Richardson R., Souter M.A., Chang A., Marovic P., O'Leary J.S., Eastwood H., O'Leary S.J., Monksfield P., Kel G., and Connolly T.
- Abstract
This study reviews the cochlear histology from four hearing preservation cochlear implantation experiments conducted on 73 guinea pigs from our institution, and relates histopathological findings to residual hearing. All guinea pigs had normal hearing prior to surgery and underwent cochlear implantation via a cochleostomy with a silastic-platinum dummy electrode. Pure tone auditory brainstem response (ABR) thresholds from 2 to 32 kHz were recorded prior to surgery, and at one and four weeks postoperatively. The cochleae were then fixed in paraformaldehyde, decalcified, paraffin embedded, and mid-modiolar sections were prepared. The treatment groups were as follows: 1) Systemic dexamethasone, 0.2 mg/kg administered 1 h before implantation, 2) Local dexamethasone, 2% applied topically to the round window for 30 min prior to cochlear implantation, 3) Local n-acetyl cysteine, 200 mug applied topically to the round window for 30 min prior to implantation, 4) inoculation to keyhole-limpet hemocyanin (KLH) prior to implantation, and 5) untreated controls. There was a significant correlation between the extent of the tissue reaction in the cochlea and the presence of foreign body giant cells (FBGCs), new bone formation and injury to the osseous spiral lamina (OSL). The extent of the tissue response, as a percentage of the area of the scala tympani, limited the best hearing that was observed four weeks after cochlear implantation. Poorer hearing at four weeks correlated with a more extensive tissue response, lower outer hair cell (OHC) counts and OSL injury in the basal turn. Progressive hearing loss was also correlated with the extent of tissue response. Hearing at 2 kHz, which corresponds to the region of the second cochlear turn, did not correspond with loco-regional inner hair cell (IHC), OHC or SGC counts. We conclude that cochlear injury is associated with poorer hearing early after implantation. The tissue response is related to indices of cochlear inflammation and in
- Published
- 2013
27. Relations between cochlear histopathology and hearing loss in experimental cochlear implantation.
- Author
-
Richardson R., Souter M.A., Chang A., Marovic P., O'Leary J.S., Eastwood H., O'Leary S.J., Monksfield P., Kel G., Connolly T., Richardson R., Souter M.A., Chang A., Marovic P., O'Leary J.S., Eastwood H., O'Leary S.J., Monksfield P., Kel G., and Connolly T.
- Abstract
This study reviews the cochlear histology from four hearing preservation cochlear implantation experiments conducted on 73 guinea pigs from our institution, and relates histopathological findings to residual hearing. All guinea pigs had normal hearing prior to surgery and underwent cochlear implantation via a cochleostomy with a silastic-platinum dummy electrode. Pure tone auditory brainstem response (ABR) thresholds from 2 to 32 kHz were recorded prior to surgery, and at one and four weeks postoperatively. The cochleae were then fixed in paraformaldehyde, decalcified, paraffin embedded, and mid-modiolar sections were prepared. The treatment groups were as follows: 1) Systemic dexamethasone, 0.2 mg/kg administered 1 h before implantation, 2) Local dexamethasone, 2% applied topically to the round window for 30 min prior to cochlear implantation, 3) Local n-acetyl cysteine, 200 mug applied topically to the round window for 30 min prior to implantation, 4) inoculation to keyhole-limpet hemocyanin (KLH) prior to implantation, and 5) untreated controls. There was a significant correlation between the extent of the tissue reaction in the cochlea and the presence of foreign body giant cells (FBGCs), new bone formation and injury to the osseous spiral lamina (OSL). The extent of the tissue response, as a percentage of the area of the scala tympani, limited the best hearing that was observed four weeks after cochlear implantation. Poorer hearing at four weeks correlated with a more extensive tissue response, lower outer hair cell (OHC) counts and OSL injury in the basal turn. Progressive hearing loss was also correlated with the extent of tissue response. Hearing at 2 kHz, which corresponds to the region of the second cochlear turn, did not correspond with loco-regional inner hair cell (IHC), OHC or SGC counts. We conclude that cochlear injury is associated with poorer hearing early after implantation. The tissue response is related to indices of cochlear inflammation and in
- Published
- 2013
28. Novel biomaterials for pelvic organ prolapse (POP) repair.
- Author
-
Supit T., White J., Rosamilia A., Lo L., Edwards S., Ramshaw J., Werkmeister J., Gargett C., Ulrich D., Supit T., White J., Rosamilia A., Lo L., Edwards S., Ramshaw J., Werkmeister J., Gargett C., and Ulrich D.
- Abstract
POP is the descent of one or more of the pelvic structures into the vagina and includes uterine, vaginal vault as well as anterior and posterior vaginal wall prolapse. Treatment of POP includes surgical treatment and/or implantation of synthetic mesh. However, the long-term outcome of synthetic mesh surgery is unsatisfactory due to surgical failure and post-surgical complications. We have fabricated 3 novel warpknitted synthetic scaffolds, Polyetheretherketone (PEEK), Polyamide (PA) and gelatine coated PA (PA+G). Our aim was to compare the in vivo biocompatibility of these meshes with a commercial Polypropylene (PP) mesh. A SD rat abdominal hernia model was used to implant PA, PEEK, PA+G, PP meshes (25 . 35 mm, n = 24/gp). After 7, 30, 60, 90 days tissues (n = 6/mesh) were explanted for immunohistochemical assessment of foreign body reaction and tissue integration, using CD31, CD45, CD68, alpha-SMA antibodies. CD68+ macrophages showed a trend toward decreased numbers in PP compared to PA, PA+G and PEEK. The smooth muscle content at 60 days was significantly higher in PA and PA+G meshes compared to PP (p > 0.05), but there were no significant differences at 90 days. The collagen content was similar for all meshes at 90 days(p > 0.05). PA, PA+G and PEEK appear to have similar biocompatibility properties compared to PP, inducing a similar foreign body reaction response. These novel meshes may provide an alternative option for future treatment of POP.
- Published
- 2012
29. A Preclinical Evaluation of Alternative Synthetic Biomaterials for Fascial Defect Repair Using a Rat Abdominal Hernia Model.
- Author
-
Rosamilia A., Gargett C.E., White J.F., Supit T., Ramshaw J.A.M., Lo C., Werkmeister J.A., Ulrich D., Edwards S.L., Rosamilia A., Gargett C.E., White J.F., Supit T., Ramshaw J.A.M., Lo C., Werkmeister J.A., Ulrich D., and Edwards S.L.
- Abstract
Introduction: Fascial defects are a common problem in the abdominal wall and in the vagina leading to hernia or pelvic organ prolapse that requires mesh enhancement to reduce operation failure. However, the long-term outcome of synthetic mesh surgery may be unsatisfactory due to post-surgical complications. We hypothesized that mesh fabricated from alternative synthetic polymers may evoke a different tissue response, and provide more appropriate mechanical properties for hernia repair. Our aim was to compare the in vivo biocompatibility of new synthetic meshes with a commercial mesh. Method(s): We have fabricated 3 new warp-knitted synthetic meshes from different polymers with different tensile properties polyetheretherketone (PEEK), polyamide (PA) and a composite, gelatin coated PA (PA+G). The rat abdominal hernia model was used to implant the meshes (25x35 mm, n = 24/ group). After 7, 30, 60, 90 days tissues were explanted for immunohistochemical assessment of foreign body reaction and tissue integration, using CD31, CD45, CD68, alpha-SMA antibodies. The images were analysed using an image analysis software program. Biomechanical properties were uniaxially evaluated using an Instron Tensile Tester. Result(s): This study showed that the new meshes induced complex differences in the type of foreign body reaction over the time course of implantation. The PA, and particularly the composite PA+G meshes, evoked a milder early inflammatory response, and macrophages were apparent throughout the time course. Our meshes led to better tissue integration and new collagen deposition, particularly with the PA+G meshes, as well as greater and sustained neovascularisation compared with the PP meshes. Conclusion(s): PA, PA+G and PEEK appear to be well tolerated and are biocompatible, evoking an overlapping and different host tissue response with time that might convey mechanical variations in the healing tissue. These new meshes comprising different polymers may provide an alterna
- Published
- 2012
30. A Preclinical Evaluation of Alternative Synthetic Biomaterials for Fascial Defect Repair Using a Rat Abdominal Hernia Model.
- Author
-
Rosamilia A., Gargett C.E., White J.F., Supit T., Ramshaw J.A.M., Lo C., Werkmeister J.A., Ulrich D., Edwards S.L., Rosamilia A., Gargett C.E., White J.F., Supit T., Ramshaw J.A.M., Lo C., Werkmeister J.A., Ulrich D., and Edwards S.L.
- Abstract
Introduction: Fascial defects are a common problem in the abdominal wall and in the vagina leading to hernia or pelvic organ prolapse that requires mesh enhancement to reduce operation failure. However, the long-term outcome of synthetic mesh surgery may be unsatisfactory due to post-surgical complications. We hypothesized that mesh fabricated from alternative synthetic polymers may evoke a different tissue response, and provide more appropriate mechanical properties for hernia repair. Our aim was to compare the in vivo biocompatibility of new synthetic meshes with a commercial mesh. Method(s): We have fabricated 3 new warp-knitted synthetic meshes from different polymers with different tensile properties polyetheretherketone (PEEK), polyamide (PA) and a composite, gelatin coated PA (PA+G). The rat abdominal hernia model was used to implant the meshes (25x35 mm, n = 24/ group). After 7, 30, 60, 90 days tissues were explanted for immunohistochemical assessment of foreign body reaction and tissue integration, using CD31, CD45, CD68, alpha-SMA antibodies. The images were analysed using an image analysis software program. Biomechanical properties were uniaxially evaluated using an Instron Tensile Tester. Result(s): This study showed that the new meshes induced complex differences in the type of foreign body reaction over the time course of implantation. The PA, and particularly the composite PA+G meshes, evoked a milder early inflammatory response, and macrophages were apparent throughout the time course. Our meshes led to better tissue integration and new collagen deposition, particularly with the PA+G meshes, as well as greater and sustained neovascularisation compared with the PP meshes. Conclusion(s): PA, PA+G and PEEK appear to be well tolerated and are biocompatible, evoking an overlapping and different host tissue response with time that might convey mechanical variations in the healing tissue. These new meshes comprising different polymers may provide an alterna
- Published
- 2012
31. Novel biomaterials for pelvic organ prolapse (POP) repair.
- Author
-
Supit T., White J., Rosamilia A., Lo L., Edwards S., Ramshaw J., Werkmeister J., Gargett C., Ulrich D., Supit T., White J., Rosamilia A., Lo L., Edwards S., Ramshaw J., Werkmeister J., Gargett C., and Ulrich D.
- Abstract
POP is the descent of one or more of the pelvic structures into the vagina and includes uterine, vaginal vault as well as anterior and posterior vaginal wall prolapse. Treatment of POP includes surgical treatment and/or implantation of synthetic mesh. However, the long-term outcome of synthetic mesh surgery is unsatisfactory due to surgical failure and post-surgical complications. We have fabricated 3 novel warpknitted synthetic scaffolds, Polyetheretherketone (PEEK), Polyamide (PA) and gelatine coated PA (PA+G). Our aim was to compare the in vivo biocompatibility of these meshes with a commercial Polypropylene (PP) mesh. A SD rat abdominal hernia model was used to implant PA, PEEK, PA+G, PP meshes (25 . 35 mm, n = 24/gp). After 7, 30, 60, 90 days tissues (n = 6/mesh) were explanted for immunohistochemical assessment of foreign body reaction and tissue integration, using CD31, CD45, CD68, alpha-SMA antibodies. CD68+ macrophages showed a trend toward decreased numbers in PP compared to PA, PA+G and PEEK. The smooth muscle content at 60 days was significantly higher in PA and PA+G meshes compared to PP (p > 0.05), but there were no significant differences at 90 days. The collagen content was similar for all meshes at 90 days(p > 0.05). PA, PA+G and PEEK appear to have similar biocompatibility properties compared to PP, inducing a similar foreign body reaction response. These novel meshes may provide an alternative option for future treatment of POP.
- Published
- 2012
32. Estenosis vestibular nasal: caso clinico
- Author
-
Fernández Rodríguez, Ana, Morais Pérez, Darío, Santos Pérez, Jaime, Blanco Mateos, Gonzalo, Millás Gómez, Teresa, Landinez Cepeda, Guillermo Arturo, Fernández Rodríguez, Ana, Morais Pérez, Darío, Santos Pérez, Jaime, Blanco Mateos, Gonzalo, Millás Gómez, Teresa, and Landinez Cepeda, Guillermo Arturo
- Published
- 2010
33. Estenosis vestibular nasal: caso clinico
- Author
-
Fernández Rodríguez, Ana, Morais Pérez, Darío, Santos Pérez, Jaime, Blanco Mateos, Gonzalo, Millás Gómez, Teresa, Landínez Cepeda, Guillermo, Fernández Rodríguez, Ana, Morais Pérez, Darío, Santos Pérez, Jaime, Blanco Mateos, Gonzalo, Millás Gómez, Teresa, and Landínez Cepeda, Guillermo
- Abstract
Iatrogenic vestibular stenosis is a blockage of the nasal vestibule caused by a disruption of the vestibular lining with secondary proliferation of fibrous tissue scar and granulation. It is more common as a result of foreign body reaction or nasal trauma. The lesions usually include the lobby and the anterior inferior turbinate. We report the case of a girl of eleven, with a complete and recurrent stenosis of the right nasal vestibule, and whose history was spent in the incubator at birth and feeding tube during this period with repeated aspirations traumatic nostril., La estenosis vestibular yatrogénica es una obstrucción del vestíbulo nasal causado por una disrupción del revestimiento vestibular con proliferación cicatricial secundaria de tejido fibroso y de granulación. Es más frecuente como resultado de una reacción de cuerpo extraño o un trauma nasal. Las lesiones suelen incluir el vestíbulo y la zona anterior del cornete inferior. Presentamos el caso de una niña de once años, con una estenosis completa y recidivada del vestíbulo nasal derecho, y entre cuyos antecedentes se encontraba la permanencia en incubadora al nacer y sonda de alimentación durante ese periodo junto con repetidas y traumáticas aspiraciones por fosa nasal.
- Published
- 2010
34. Estenosis vestibular nasal: caso clinico
- Author
-
Fernández Rodríguez, Ana, Morais Pérez, Darío, Santos Pérez, Jaime, Blanco Mateos, Gonzalo, Millás Gómez, Teresa, Landínez Cepeda, Guillermo, Fernández Rodríguez, Ana, Morais Pérez, Darío, Santos Pérez, Jaime, Blanco Mateos, Gonzalo, Millás Gómez, Teresa, and Landínez Cepeda, Guillermo
- Abstract
Iatrogenic vestibular stenosis is a blockage of the nasal vestibule caused by a disruption of the vestibular lining with secondary proliferation of fibrous tissue scar and granulation. It is more common as a result of foreign body reaction or nasal trauma. The lesions usually include the lobby and the anterior inferior turbinate. We report the case of a girl of eleven, with a complete and recurrent stenosis of the right nasal vestibule, and whose history was spent in the incubator at birth and feeding tube during this period with repeated aspirations traumatic nostril., La estenosis vestibular yatrogénica es una obstrucción del vestíbulo nasal causado por una disrupción del revestimiento vestibular con proliferación cicatricial secundaria de tejido fibroso y de granulación. Es más frecuente como resultado de una reacción de cuerpo extraño o un trauma nasal. Las lesiones suelen incluir el vestíbulo y la zona anterior del cornete inferior. Presentamos el caso de una niña de once años, con una estenosis completa y recidivada del vestíbulo nasal derecho, y entre cuyos antecedentes se encontraba la permanencia en incubadora al nacer y sonda de alimentación durante ese periodo junto con repetidas y traumáticas aspiraciones por fosa nasal.
- Published
- 2010
35. Histopathology of explanted AlphaCor due to keratoprosthesis extrusion
- Author
-
Caporossi, Aldo, Mazzotta, Cosimo, Balestrazzi, Angelo, Occhini, Rossella, Toti, Paolo, Traversi, Claudio, Caporossi, Aldo (ORCID:0000-0002-8680-3773), Caporossi, Aldo, Mazzotta, Cosimo, Balestrazzi, Angelo, Occhini, Rossella, Toti, Paolo, Traversi, Claudio, and Caporossi, Aldo (ORCID:0000-0002-8680-3773)
- Abstract
AlphaCor keratoprosthesis (KPro) is a new-concept poly (2-hydroxyethyl methacrylate) one-piece KPro that makes possible a two-step implantation technique easy to perform with a short learning curve. In literature an 18% incidence of AlphaCor removal due to melting complications is reported. The histopathology of corneal tissue removed during a re-operation while bearing an AlphaCor KPro has previously been described in the literature only in one report. Herein, the first histological features of an AlphaCor-corneal complex explanted because of KPro extrusion is described. The histopathology of the AlphaCor-corneal complex is characterized by mild inflammation in the corneal tissues, limited to the region surrounding the anteriorized and extruded part of the KPro. It is not possible to fully understand the mechanisms that trigger the device extrusion. One possible explanation could be a dislocation of the prosthesis in the corneal pocket due to the untied fixation stitch. Another explanation could be a foreign body reaction induced by KPro. © 2006 Royal Australian and New Zealand College of Ophthalmologists.
- Published
- 2006
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