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1. The effects of polyunsaturated fatty acid (PUFA) administration on the microbiome-gut-brain axis in adolescents with anorexia nervosa (the MiGBAN study): study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial

Author

Keller, L., Dempfle, A., Dahmen, B., Schreiber, S., Adan, R.A.H., Andreani, N.A., Danner, U.N., Eisert, A., Fetissov, S., Fischmeister, F.Ph.S., Karwautz, A., Konrad, K., Kooij, K.L., Trinh, S., van der Vijgh, B., van Elburg, A.A., Zeiler, M., Baines, J., Seitz, J., Herpertz-Dahlmann, B., Keller, L., Dempfle, A., Dahmen, B., Schreiber, S., Adan, R.A.H., Andreani, N.A., Danner, U.N., Eisert, A., Fetissov, S., Fischmeister, F.Ph.S., Karwautz, A., Konrad, K., Kooij, K.L., Trinh, S., van der Vijgh, B., van Elburg, A.A., Zeiler, M., Baines, J., Seitz, J., and Herpertz-Dahlmann, B.

Abstract

Background: Anorexia nervosa (AN) is a severe psychiatric disease that often takes a chronic course due to insufficient treatment options. Emerging evidence on the gut-brain axis offers the opportunity to find innovative treatments for patients with psychiatric disorders. The gut microbiome of patients with AN shows profound alterations that do not completely disappear after weight rehabilitation. In previous studies, the administration of polyunsaturated fatty acids (PUFA) resulted in effects that might be beneficial in the treatment of AN, affecting the microbiome, body weight and executive functions. Therefore, the MiGBAN study aims to examine the effects of a nutritional supplementation with PUFA on the gut microbiome and body mass index (BMI) in patients with AN. Methods: This is a longitudinal, double-blind, randomized, placebo-controlled trial. Within 2 years, 60 adolescent patients aged 12 to 19 years with AN will receive either PUFA or placebo for 6 months additional to treatment as usual. After 1 year, the long-term effect of PUFA on the gut microbiome and consecutively on BMI will be determined. Secondary outcomes include improvement of gastrointestinal symptoms, eating disorder psychopathology, and comorbidities. Additionally, the interaction of the gut microbiome with the brain (microbiome-gut-brain axis) will be studied by conducting MRI measurements to assess functional and morphological changes and neuropsychological assessments to describe cognitive functioning. Anti-inflammatory effects of PUFA in AN will be examined via serum inflammation and gut permeability markers. Our hypothesis is that PUFA administration will have positive effects on the gut microbiota and thus the treatment of AN by leading to a faster weight gain and a reduction of gastrointestinal problems and eating disorder psychopathology. Discussion: Due to previously heterogeneous results, a systematic and longitudinal investigation of the microbiome-gut-br

Published
2022

2. The effects of probiotics administration on the gut microbiome in adolescents with anorexia nervosa—: A study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial

Author

Gröbner, E.M., Zeiler, M., Fischmeister, F.Ph.S., Kollndorfer, K., Schmelz, S., Schneider, A., Haid-Stecher, N., Sevecke, K., Wagner, G., Keller, L., Adan, R., Danner, U.N., van Elburg, A.A., van der Vijgh, B., Kooij, K.L., Fetissov, S., Andreani, N.A., Baines, J.F., Dempfle, A., Seitz, J., Herpertz-Dahlmann, B., Karwautz, A., Gröbner, E.M., Zeiler, M., Fischmeister, F.Ph.S., Kollndorfer, K., Schmelz, S., Schneider, A., Haid-Stecher, N., Sevecke, K., Wagner, G., Keller, L., Adan, R., Danner, U.N., van Elburg, A.A., van der Vijgh, B., Kooij, K.L., Fetissov, S., Andreani, N.A., Baines, J.F., Dempfle, A., Seitz, J., Herpertz-Dahlmann, B., and Karwautz, A.

Abstract

Objective: Knowledge on gut–brain interaction might help to develop new therapies for patients with anorexia nervosa (AN), as severe starvation-induced changes of the microbiome (MI) do not normalise with weight gain. We examine the effects of probiotics supplementation on the gut MI in patients with AN. Method: This is a study protocol for a two-centre double-blind randomized-controlled trial comparing the clinical efficacy of multistrain probiotic administration in addition to treatment-as-usual compared to placebo in 60 patients with AN (13–19 years). Moreover, 60 sex- and age-matched healthy controls are included in order to record development-related changes. Assessments are conducted at baseline, discharge, 6 and 12 months after baseline. Assessments include measures of body mass index, psychopathology (including eating-disorder-related psychopathology, depression and anxiety), neuropsychological measures, serum and stool analyses. We hypothesise that probiotic administration will have positive effects on the gut microbiota and the treatment of AN by improvement of weight gain, gastrointestinal complaints and psychopathology, and reduction of inflammatory processes compared to placebo. Conclusions: If probiotics could help to normalise the MI composition, reduce inflammation and gastrointestinal discomfort and increase body weight, its administration would be a readily applicable additional component of multi-modal AN treatment.

Published
2022

3. The effects of probiotics administration on the gut microbiome in adolescents with anorexia nervosa—: A study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial

Author

Trauma and Grief, Leerstoel Boelen, Leerstoel Engelhard, Experimental psychopathology, Gröbner, E.M., Zeiler, M., Fischmeister, F.Ph.S., Kollndorfer, K., Schmelz, S., Schneider, A., Haid-Stecher, N., Sevecke, K., Wagner, G., Keller, L., Adan, R., Danner, U.N., van Elburg, A.A., van der Vijgh, B., Kooij, K.L., Fetissov, S., Andreani, N.A., Baines, J.F., Dempfle, A., Seitz, J., Herpertz-Dahlmann, B., Karwautz, A., Trauma and Grief, Leerstoel Boelen, Leerstoel Engelhard, Experimental psychopathology, Gröbner, E.M., Zeiler, M., Fischmeister, F.Ph.S., Kollndorfer, K., Schmelz, S., Schneider, A., Haid-Stecher, N., Sevecke, K., Wagner, G., Keller, L., Adan, R., Danner, U.N., van Elburg, A.A., van der Vijgh, B., Kooij, K.L., Fetissov, S., Andreani, N.A., Baines, J.F., Dempfle, A., Seitz, J., Herpertz-Dahlmann, B., and Karwautz, A.

Published
2022

4. The effects of polyunsaturated fatty acid (PUFA) administration on the microbiome-gut-brain axis in adolescents with anorexia nervosa (the MiGBAN study): study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial

Author

Trauma and Grief, Leerstoel Boelen, Leerstoel Engelhard, Experimental psychopathology, Keller, L., Dempfle, A., Dahmen, B., Schreiber, S., Adan, R.A.H., Andreani, N.A., Danner, U.N., Eisert, A., Fetissov, S., Fischmeister, F.Ph.S., Karwautz, A., Konrad, K., Kooij, K.L., Trinh, S., van der Vijgh, B., van Elburg, A.A., Zeiler, M., Baines, J., Seitz, J., Herpertz-Dahlmann, B., Trauma and Grief, Leerstoel Boelen, Leerstoel Engelhard, Experimental psychopathology, Keller, L., Dempfle, A., Dahmen, B., Schreiber, S., Adan, R.A.H., Andreani, N.A., Danner, U.N., Eisert, A., Fetissov, S., Fischmeister, F.Ph.S., Karwautz, A., Konrad, K., Kooij, K.L., Trinh, S., van der Vijgh, B., van Elburg, A.A., Zeiler, M., Baines, J., Seitz, J., and Herpertz-Dahlmann, B.

Published
2022

5. The effects of probiotics administration on the gut microbiome in adolescents with anorexia nervosa—: A study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial

Author

Trauma and Grief, Leerstoel Boelen, Leerstoel Engelhard, Experimental psychopathology, Gröbner, E.M., Zeiler, M., Fischmeister, F.Ph.S., Kollndorfer, K., Schmelz, S., Schneider, A., Haid-Stecher, N., Sevecke, K., Wagner, G., Keller, L., Adan, R., Danner, U.N., van Elburg, A.A., van der Vijgh, B., Kooij, K.L., Fetissov, S., Andreani, N.A., Baines, J.F., Dempfle, A., Seitz, J., Herpertz-Dahlmann, B., Karwautz, A., Trauma and Grief, Leerstoel Boelen, Leerstoel Engelhard, Experimental psychopathology, Gröbner, E.M., Zeiler, M., Fischmeister, F.Ph.S., Kollndorfer, K., Schmelz, S., Schneider, A., Haid-Stecher, N., Sevecke, K., Wagner, G., Keller, L., Adan, R., Danner, U.N., van Elburg, A.A., van der Vijgh, B., Kooij, K.L., Fetissov, S., Andreani, N.A., Baines, J.F., Dempfle, A., Seitz, J., Herpertz-Dahlmann, B., and Karwautz, A.

Published
2022

6. The effects of polyunsaturated fatty acid (PUFA) administration on the microbiome-gut-brain axis in adolescents with anorexia nervosa (the MiGBAN study): study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial

Author

Trauma and Grief, Leerstoel Boelen, Leerstoel Engelhard, Experimental psychopathology, Keller, L., Dempfle, A., Dahmen, B., Schreiber, S., Adan, R.A.H., Andreani, N.A., Danner, U.N., Eisert, A., Fetissov, S., Fischmeister, F.Ph.S., Karwautz, A., Konrad, K., Kooij, K.L., Trinh, S., van der Vijgh, B., van Elburg, A.A., Zeiler, M., Baines, J., Seitz, J., Herpertz-Dahlmann, B., Trauma and Grief, Leerstoel Boelen, Leerstoel Engelhard, Experimental psychopathology, Keller, L., Dempfle, A., Dahmen, B., Schreiber, S., Adan, R.A.H., Andreani, N.A., Danner, U.N., Eisert, A., Fetissov, S., Fischmeister, F.Ph.S., Karwautz, A., Konrad, K., Kooij, K.L., Trinh, S., van der Vijgh, B., van Elburg, A.A., Zeiler, M., Baines, J., Seitz, J., and Herpertz-Dahlmann, B.

Published
2022

7. The effects of probiotics administration on the gut microbiome in adolescents with anorexia nervosa—: A study protocol for a longitudinal, double-blind, randomized, placebo-controlled trial

Author

Trauma and Grief, Leerstoel Boelen, Leerstoel Engelhard, Experimental psychopathology, Gröbner, E.M., Zeiler, M., Fischmeister, F.Ph.S., Kollndorfer, K., Schmelz, S., Schneider, A., Haid-Stecher, N., Sevecke, K., Wagner, G., Keller, L., Adan, R., Danner, U.N., van Elburg, A.A., van der Vijgh, B., Kooij, K.L., Fetissov, S., Andreani, N.A., Baines, J.F., Dempfle, A., Seitz, J., Herpertz-Dahlmann, B., Karwautz, A., Trauma and Grief, Leerstoel Boelen, Leerstoel Engelhard, Experimental psychopathology, Gröbner, E.M., Zeiler, M., Fischmeister, F.Ph.S., Kollndorfer, K., Schmelz, S., Schneider, A., Haid-Stecher, N., Sevecke, K., Wagner, G., Keller, L., Adan, R., Danner, U.N., van Elburg, A.A., van der Vijgh, B., Kooij, K.L., Fetissov, S., Andreani, N.A., Baines, J.F., Dempfle, A., Seitz, J., Herpertz-Dahlmann, B., and Karwautz, A.

Published
2022

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