1. A New Complex of Palladium(II) With 2-Furoic Hydrazide: Synthesis, Characterization, Theoretical Calculations and Biological Studies
- Author
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Gustavo Duarte de Souza, Mônica Aparecida Rodrigues, Priscila Pereira Silva, Elene Cristina Pereira-Maia, Françoise Vasconcelos Botelho, Tatiana Amabile de Campos, Eduardo de Faria Franca, Katia Júlia de Almeida, Wendell Guerra, Gustavo Duarte de Souza, Mônica Aparecida Rodrigues, Priscila Pereira Silva, Elene Cristina Pereira-Maia, Françoise Vasconcelos Botelho, Tatiana Amabile de Campos, Eduardo de Faria Franca, Katia Júlia de Almeida, and Wendell Guerra
- Abstract
A new complex of palladium was isolated with 2-furoic hydrazide (FH) and characterized by spectroscopic methods. The results show that the ligand is coordinated to palladium by the basic nitrogen of NH2 group and has a general structure of type cis-[Pd(FH)2Cl2]. The structure of palladium(II) complex was optimized and theoretical data show good agreement with the experimental results. The cytotoxic activity was evaluated in a chronic myelogenous leukemia cell line, which revealed that the compound is less active than cisplatin or carboplatin. At 300 g mL−1, the complex presented antimicrobial activity more efficient than ampicillin, chloranfenicol and kanamicyn. (doi: 10.5562/cca2151)
- Published
- 2013