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Ali Mobasheri,1– 4 Aliyyaa Spring-Charles,5 Francesco Carlo Gamaleri,6 Joyce McSwan,7 Manohar Garg,8 Vidhu Sood Sethi9 1Research Unit of Health Sciences and Technology, Physics and Technology, University of Oulu, Oulu, Finland; 2Department of Regenerative Medicine, State Research Institute Centre for Innovative Medicine, Vilnius, Lithuania; 3Department of Joint Surgery, Sun Yat-sen University, Guangzhou, People’s Republic of China; 4World Health Organization Collaborating Center for Public Health Aspects of Musculoskeletal Health and Aging, Université de Liège, Liège, Belgium; 5Hope Spring Clinic, London, UK; 6Pharmacy San Rocco, Cornaredo (Milan), Italy; 7PainWISE Pty Ltd, Gold Coast, Queensland, Australia; 8Nutraceuticals Research Program, University of Newcastle, Callaghan, Newcastle, NSW, Australia; 9Medical Affairs, Haleon (Formerly GlaxoSmithKline Consumer Healthcare) Pte. Ltd., SingaporeCorrespondence: Vidhu Sood Sethi, Haleon (Formerly GlaxoSmithKline Consumer Healthcare) Pte. Ltd., Singapore, Tel +65 96447203, Email vidhu.x.sethi@haleon.comBackground: Pharmacological approaches to acute and chronic pain management, including non-steroidal anti-inflammatory drugs (NSAIDs) and opioids, are respectively associated with adverse reactions (such as gastrointestinal, cardiovascular, and renal effects) that might limit their use in patients with comorbidities and controversy related to inappropriate use. Naturopathic remedies might offer patients alternative and integrative treatments with minimal side effects.Objective: To explore the regional variation in the acceptance and use of naturopathic remedies in pain management.Methods: Two expert panel discussions were held by GlaxoSmithKline Consumer Healthcare (now Haleon Pte. Ltd.) over 9 and 12 hours in 2020 and 2021, respectively, and attended by multidisciplinary experts in naturopathy, Ayurvedic medicine, community pharmacy, physiotherapy, clinical pharmacy, Western medicine, academics, and naturopathic p