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Construction logistics is one of the essential functions in the modular construction industry due to the high demand for on-time delivery of components. For modular component suppliers, there is minimal flexibility in delivery times as generally, the installation times of modular components are critical to the contractor’s construction programme. There are several studies conducted in recent years that articulate novel methodologies in construction logistics scheduling; however, the industry still faces challenges in streamlining the whole supply chain to better cater to potential uncertainties that impact construction logistics. This paper looks at a case study on a modular component supplier in Melbourne, with regarding to the challenges faced and how they have effectively overcome these challenges and provides a framework to mitigate construction logistics related discrepancies in the supply chain. The resilience of these methods in facing unforeseen events such as COVID-19 will also be discussed. The overarching objectives of this paper are to include: (1) bibliographic mapping of related publications; (2) identification of current methods, problems and technologies used in modular construction logistics; and (3) propose best practice guidelines that can be implemented to effectively cater to such uncertainties in construction logistics to minimise the impact on the supply chain. Further, incorporating lean principles for planning construction logistics and transport for the modular construction industry is also in discussion. Finally, the potential future research directions are highlighted to guide the researchers to pursue areas of much importance.

Modular construction facilities operate under tight deadlines making the monitoring of manufacturing progress and delivery for optimal factory-to-site operations a significant challenge. This paper presents an action research study that assisted in enhancing the productivity of a manufacturing execution and control system implemented at a facility in Melbourne, Australia. This system monitors production processes, and shares information for timely, well-informed decision-making using an online platform and a mobile app, developed using lean principles. The results showed significant time and cost savings, quality improvement and increased visibility of inefficiencies and will serve as a helpful reference for construction factory managers wishing to improve their manufacturing systems.

Histone H4 acetylation at Lysine 16 (H4K16ac) is a key epigenetic mark involved in gene regulation, DNA repair and chromatin remodeling, and though it is known to be essential for embryonic development, its role during adult life is still poorly understood. Here we show that this lysine is massively hyperacetylated in peripheral neutrophils. Genome-wide mapping of H4K16ac in terminally differentiated blood cells, along with functional experiments, supported a role for this histone post-translational modification in the regulation of cell differentiation and apoptosis in the hematopoietic system. Furthermore, in neutrophils, H4K16ac was enriched at specific DNA repeats. These DNA regions presented an accessible chromatin conformation and were associated with the cleavage sites that generate the 50 kb DNA fragments during the first stages of programmed cell death. Our results thus suggest that H4K16ac plays a dual role in myeloid cells as it not only regulates differentiation and apoptosis, but it also exhibits a non-canonical structural role in poising chromatin for cleavage at an early stage of neutrophil cell death.

BACKGROUND: Telemedicine and digital health technologies hold great promise for improving clinical care of heart failure. However, inconsistent and contradictory findings from randomized controlled trials have so far discouraged widespread adoption of digital health in routine clinical practice. We undertook this review study to summarize the study outcomes of the use of exploring the evidence for telemedicine in the clinical care of patients with heart failure and readmissions. METHODS: We inspected the references of guidelines and searched PubMed for randomized controlled trials published over the past 10 years on the use of telemedicine for reducing readmission in heart failure. We utilized a modified realist review approach to identify the underlying contextual mechanisms for the intervention(s) in each randomized controlled trial, evaluating outcomes of the intervention and understanding how and under what conditions they worked. To provide uniformity, all extracted data were synthesized using adapted domains from the taxonomy for disease management created by the Disease Management Taxonomy Writing Group. RESULTS: A total of 12 papers were eligible, 6 of them supporting and 6 others undermining the use of telemedicine for improving heart failure readmission. In general terms, those studies not supporting the use of telemedicine were multicentre, publicly funded, with large amount of participants, and long duration. The patients had also better rates of treatment with angiotensin-converting enzyme inhibitors/angiotensin II receptor blocker and beta-blockers, and telemonitoring and automatic transmission of vital signs were less utilized, in comparison with the studies in which telemedicine use was supported. The analysis of the environment, intensity, content of interventions, method of communication, quality of the underlying model of care and the ability, capability, and interest from health workers can help us to envisage probabilities of success of telemedi