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1. Correction: Health-related quality-of-life trajectories during/after surgery and adjuvant chemotherapy in patients with colon cancer (European Geriatric Medicine, (2023), 14, 3, (565-572), 10.1007/s41999-023-00750-9)

Author

Onderzoek Medische Oncologie, Cancer, MS Geriatrie, Circulatory Health, Scheepers, E R M, Vink, G R, Schiphorst, A H W, Emmelot-Vonk, M H, van Huis-Tanja, L H, Hamaker, M E, Onderzoek Medische Oncologie, Cancer, MS Geriatrie, Circulatory Health, Scheepers, E R M, Vink, G R, Schiphorst, A H W, Emmelot-Vonk, M H, van Huis-Tanja, L H, and Hamaker, M E

Published
2023

2. Frailty screening in dermato-oncology practice: a modified Delphi study and a systematic review of the literature

Author

van Winden, M. E. C., Garcovich, Simone, Peris, Ketty, Colloca, Giuseppe Ferdinando, de Jong, E. M. G. J., Hamaker, M. E., van de Kerkhof, P. C. M., Lubeek, S. F. K., Garcovich S. (ORCID:0000-0001-8967-6688), Peris K. (ORCID:0000-0002-5237-0463), Colloca G., van Winden, M. E. C., Garcovich, Simone, Peris, Ketty, Colloca, Giuseppe Ferdinando, de Jong, E. M. G. J., Hamaker, M. E., van de Kerkhof, P. C. M., Lubeek, S. F. K., Garcovich S. (ORCID:0000-0001-8967-6688), Peris K. (ORCID:0000-0002-5237-0463), and Colloca G.

Abstract

Background: Appropriate management and prevention of both under- and overtreatment in older skin cancer patients can be challenging. It could be helpful to incorporate frailty screening in dermato-oncology care, since frailty is associated with adverse health outcomes. Objectives: This study aimed to identify and prioritize the requirements a frailty screening tool (FST) should fulfil in dermato-oncology practice and to select the best existing FST(s) for this purpose. Methods: A modified two-round Delphi procedure was performed among 50 Italian and Dutch specialists and patients to review and prioritize a list of potential FST requirements, using a 5-point Likert scale. Consensus was defined as a mean score of ≥4.0. A systematic literature search was performed to identify existing multidomain FSTs, which were then assessed on the requirements resulting from the modified Delphi procedure. Results: Consensus was achieved on evaluation of comorbidities (4.3 ± 0.7), polypharmacy (4.0 ± 0.9) and cognition (4.1 ± 0.8). The FST should have appropriate measurement properties (4.0 ± 1.0), be quickly executed (4.2 ± 0.7), clinically relevant (4.3 ± 0.7), and both easily understandable (4.1 ± 1.2) and interpretable (4.3 ± 0.7). Of the 26 identified FSTs, four evaluated the content-related domains: the Geriatric-8 (G8), the modified Geriatric-8 (mG8), the Groningen Frailty Indicator (GFI) and the Senior Adult Oncology Program 2 (SAOP2) screening tool. Of these, the G8 was the most extensively studied FST, with the best psychometric properties and execution within 5 min. Conclusions: The G8 appears the most suitable FST for assessing frailty in older adults with skin cancer, although clinical studies assessing its use in a dermato-oncology population are needed to further assess whether or not frailty in this particular patient group is associated with relevant outcomes (e.g. complications and

Published
2021

8. The association between chronic kidney disease, falls, and fractures: a systematic review and meta-analysis

Author

Unit Opleiding Geriatrie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Goto, N A, Weststrate, A C G, Oosterlaan, F M, Verhaar, M C, Willems, H C, Emmelot-Vonk, M H, Hamaker, M E, Unit Opleiding Geriatrie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Goto, N A, Weststrate, A C G, Oosterlaan, F M, Verhaar, M C, Willems, H C, Emmelot-Vonk, M H, and Hamaker, M E

Published
2020

11. The Prognostic Value of a Geriatric Risk Score for Older Patients with Colorectal Cancer

Author

Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, van den Bos, F, Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, and van den Bos, F

Published
2019

15. The Prognostic Value of a Geriatric Risk Score for Older Patients with Colorectal Cancer

Author

Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, van den Bos, F, Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, and van den Bos, F

Published
2019

19. The Prognostic Value of a Geriatric Risk Score for Older Patients with Colorectal Cancer

Author

Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, van den Bos, F, Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, and van den Bos, F

Published
2019

23. The Prognostic Value of a Geriatric Risk Score for Older Patients with Colorectal Cancer

Author

AIOS Psychiatrie, MS Geriatrie, Circulatory Health, Cardiovasculaire Epi Team 1, Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, van den Bos, F, AIOS Psychiatrie, MS Geriatrie, Circulatory Health, Cardiovasculaire Epi Team 1, Souwer, E T D, Hultink, D, Bastiaannet, E, Hamaker, M E, Schiphorst, A, Pronk, A, van der Bol, J M, Steup, W H, Dekker, J W T, Portielje, J E A, and van den Bos, F

Published
2019

24. Quality of life after the initiation of dialysis or maximal conservative management in elderly patients: a longitudinal analysis of the Geriatric assessment in OLder patients starting Dialysis (GOLD) study

Author

Unit Opleiding Aios, Unit Opleiding Geriatrie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, van Loon, I N, Goto, N A, Boereboom, F T J, Verhaar, M C, Bots, M L, Hamaker, M E, Unit Opleiding Aios, Unit Opleiding Geriatrie, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, Cardiovasculaire Epi Team 5, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, van Loon, I N, Goto, N A, Boereboom, F T J, Verhaar, M C, Bots, M L, and Hamaker, M E

Published
2019

25. Thoracic vertebral fractures and hyperkyphosis in elderly patients with end-stage kidney disease; do these patients have different clinical outcomes?

Author

Unit Opleiding Geriatrie, Unit Opleiding Aios, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Goto, N. A., Koele, M. C., van Loon, I. N., Boereboom, F. T. J., Verhaar, M. C., Emmelot-Vonk, M. H., Hamaker, M. E., Willems, H. C., Unit Opleiding Geriatrie, Unit Opleiding Aios, Nefro Vasculaire Geneeskunde, Circulatory Health, Regenerative Medicine and Stem Cells, MS Geriatrie, Goto, N. A., Koele, M. C., van Loon, I. N., Boereboom, F. T. J., Verhaar, M. C., Emmelot-Vonk, M. H., Hamaker, M. E., and Willems, H. C.

Published
2019

32. Chemotherapy and healthcare utilisation near the end of life in patients with cancer

Author

Arts Assistenten Longziekten, Longziekten, Cardiovasculaire Epi Team 1, MS Geriatrie, Circulatory Health, Directie Kwaliteit v. Zorg en Patiëntv., Infection & Immunity, Schulkes, K J G, van Walree, I C, van Elden, L J R, van den Bos, F, van Huis-Tanja, L, Lammers, J-W J, Ten Bokkel Huinink, D, Hamaker, M E, Arts Assistenten Longziekten, Longziekten, Cardiovasculaire Epi Team 1, MS Geriatrie, Circulatory Health, Directie Kwaliteit v. Zorg en Patiëntv., Infection & Immunity, Schulkes, K J G, van Walree, I C, van Elden, L J R, van den Bos, F, van Huis-Tanja, L, Lammers, J-W J, Ten Bokkel Huinink, D, and Hamaker, M E

Published
2018

33. Multidisciplinary decision-making regarding chemotherapy for lung cancer patients-An age-based comparison

Author

Arts Assistenten Longziekten, Directie Kwaliteit v. Zorg en Patiëntv., Infection & Immunity, Longziekten, Schulkes, K J G, Hamaker, M E, Lammers, J-W J, van Rens, M T M, Geerts, M, van Elden, L J R, Arts Assistenten Longziekten, Directie Kwaliteit v. Zorg en Patiëntv., Infection & Immunity, Longziekten, Schulkes, K J G, Hamaker, M E, Lammers, J-W J, van Rens, M T M, Geerts, M, and van Elden, L J R

Published
2018

34. Quality of life in elderly patients with an ostomy: A study from the population-based PROFILES registry

Author

Verweij, N. M., Bonhof, C.S., Schiphorst, A. H. W., Maas, H. A., Mols, F., Pronk, A., Hamaker, M. E., Verweij, N. M., Bonhof, C.S., Schiphorst, A. H. W., Maas, H. A., Mols, F., Pronk, A., and Hamaker, M. E.

Abstract

AimOstomies are being placed frequently in surgically treated elderly patients with colorectal cancer (CRC). An insight into the (potential) impact of ostomies on quality of life (QoL) could be useful in patient counselling as well as in the challenging shared treatment decision-making.MethodPatients with CRC diagnosed between 2000 and 2009 and registered in the population-based Eindhoven Cancer Registry received a QoL questionnaire (EORTC QLQ-C30) in 2010. In addition, QoL was compared with an age- and sex-matched normative population.ResultsThe study included 2299 CRC patients, of whom 494 had an ostomy. No differences were found in reported ostomy-related problems between patients aged 65, 66-75 and 76years. Ostomy patients aged 66-75 and 76years reported significantly lower physical functioning compared with those without an ostomy. In the elderly (those aged 76years) ostomates reported a worse physical and social functioning compared with the normative population. All these differences were of small clinical relevance. The impact of an ostomy seems to be more prominent in younger (75years old) ostomates, as they experience more functional limitations and a decrease in global health status compared with younger nonostomy patients and the normative population.ConclusionAlthough elderly (76years old) patients with an ostomy report significantly more limitations in functioning compared with a normative population and elderly CRC patients without an ostomy, the clinical relevance of this finding is limited. In contrast, the impact of an ostomy is more prominent in younger patients. Thus, age itself is not a reason for withholding an ostomy.

Published
2018

36. Quality of life as indicator of poor outcome in hemodialysis : relation with mortality in different age groups

Author

van Loon, I N, Bots, M L, Boereboom, Frans T J, Grooteman, Muriel P C, Blankestijn, P J, van den Dorpel, Marinus A., Nubé, Menso J., ter Wee, Pieter M., Verhaar, M C, Hamaker, M. E., van Loon, I N, Bots, M L, Boereboom, Frans T J, Grooteman, Muriel P C, Blankestijn, P J, van den Dorpel, Marinus A., Nubé, Menso J., ter Wee, Pieter M., Verhaar, M C, and Hamaker, M. E.

Published
2017

40. Quality of life as indicator of poor outcome in hemodialysis : relation with mortality in different age groups

Author

van Loon, I N, Bots, M L, Boereboom, Frans T J, Grooteman, Muriel P C, Blankestijn, P J, van den Dorpel, Marinus A., Nubé, Menso J., ter Wee, Pieter M., Verhaar, M C, Hamaker, M. E., van Loon, I N, Bots, M L, Boereboom, Frans T J, Grooteman, Muriel P C, Blankestijn, P J, van den Dorpel, Marinus A., Nubé, Menso J., ter Wee, Pieter M., Verhaar, M C, and Hamaker, M. E.

Published
2017

41. Management of chronic lymphocytic leukemia (CLL) in the elderly: a position paper from an international Society of Geriatric Oncology (SIOG) Task Force

Author

Stauder, R., Eichhorst, B., Hamaker, M. E., Kaplanov, K., Morrison, V. A., Osterborg, A., Poddubnaya, I., Woyach, J. A., Shanafelt, T., Smolej, L., Ysebaert, L., Goede, V., Stauder, R., Eichhorst, B., Hamaker, M. E., Kaplanov, K., Morrison, V. A., Osterborg, A., Poddubnaya, I., Woyach, J. A., Shanafelt, T., Smolej, L., Ysebaert, L., and Goede, V.

Abstract

Chronic lymphocytic leukemia (CLL) mainly affects older people: the median age at diagnosis is> 70 years. Elderly patients with CLL are heterogeneous with regard both to the biology of their disease and aging. Following the diagnosis of CLL in an elderly individual, careful risk assessment is essential when treatment options are evaluated. This includes not only clinical staging and evaluation of disease-specific prognostic biomarkers such as 17p deletion and TP53 mutation, but also of comorbidities, physical capacity, nutritional status, cognitive capacity, ability to perform activities of daily living and social support. Comorbidity scoring and geriatric assessment tools are helpful in achieving such multidimensional evaluation in a systematic manner. The introduction of new drugs including novel monoclonal antibodies and kinase inhibitors offers enhanced opportunities for the treatment of elderly patients with CLL. This position paper of a Task Force of the International Society of Geriatric Oncology (SIOG) reviews currently available evidence relevant to such patients. All types of elderly patient (i. e. chronological age> 65-70 years) are considered, from robust (fit) to vulnerable (unfit) to the terminally ill. Among the topics covered are the following: (i) the relationship between chronological age, prognosis and survival, (ii) assessment of biological aging, (iii) biological age as a determinant of treatment feasibility and tolerance and (iv) tailoring of both first and further-line treatment to the circumstances of the individual patient.

Published
2017

45. Quality of life as indicator of poor outcome in hemodialysis : relation with mortality in different age groups

Author

van Loon, I N, Bots, M L, Boereboom, Frans T J, Grooteman, Muriel P C, Blankestijn, P J, van den Dorpel, Marinus A., Nubé, Menso J., ter Wee, Pieter M., Verhaar, M C, Hamaker, M. E., van Loon, I N, Bots, M L, Boereboom, Frans T J, Grooteman, Muriel P C, Blankestijn, P J, van den Dorpel, Marinus A., Nubé, Menso J., ter Wee, Pieter M., Verhaar, M C, and Hamaker, M. E.

Published
2017

47. Outcome of very old patients admitted to the ICU for sepsis: A systematic review

Author

Infection & Immunity, MICU, UMC Utrecht, Medische Staf Intensive Care, Brain, Circulatory Health, Haas, Lenneke E M, van Dillen, L.S., de Lange, D. W., van Dijk, D., Hamaker, M. E., Infection & Immunity, MICU, UMC Utrecht, Medische Staf Intensive Care, Brain, Circulatory Health, Haas, Lenneke E M, van Dillen, L.S., de Lange, D. W., van Dijk, D., and Hamaker, M. E.

Published
2017

49. Quality of life as indicator of poor outcome in hemodialysis: relation with mortality in different age groups

Author

Unit Opleiding Aios, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, van Loon, I N, Bots, M L, Boereboom, Frans T J, Grooteman, Muriel P C, Blankestijn, P J, van den Dorpel, Marinus A., Nubé, Menso J., ter Wee, Pieter M., Verhaar, M C, Hamaker, M. E., Unit Opleiding Aios, Cardiovasculaire Epi Team 5, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Nefrologie, Nefro Vasculaire Geneeskunde, Regenerative Medicine and Stem Cells, van Loon, I N, Bots, M L, Boereboom, Frans T J, Grooteman, Muriel P C, Blankestijn, P J, van den Dorpel, Marinus A., Nubé, Menso J., ter Wee, Pieter M., Verhaar, M C, and Hamaker, M. E.

Published
2017

50. Decision making in elderly patients with lung cancer

Author

Arts Assistenten Longziekten, Lammers, Jan-Willem J., van Elden, L.J.R., Hamaker, M. E., Schulkes, K.J.G., Arts Assistenten Longziekten, Lammers, Jan-Willem J., van Elden, L.J.R., Hamaker, M. E., and Schulkes, K.J.G.

Published
2017

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