Search

Objective: To evaluate changes in the knee joints of asymptomatic first-time marathon runners, using 3.0 T MRI, 6 months after finishing marathon training and run. Materials and methods: Six months after their participation in a baseline study regarding their knee joints, 44 asymptomatic novice marathoners (17 males, 27 females, mean age 46 years old) agreed to participate in a repeat MRI investigation: 37 completed both a standardized 4-month-long training programme and the marathon (marathon runners); and 7 dropped out during training (pre-race dropouts). The participants already underwent bilateral 3.0 T MRIs: 6 months before and 2 weeks after their first marathon, the London Marathon 2017. This study was a follow-up assessment of their knee joints. Each knee structure was assessed using validated scoring/grading systems at all time points. Results: Two weeks after the marathon, 3 pre-marathon bone marrow lesions and 2 cartilage lesions showed decrease in radiological score on MRI, and the improvement was sustained at the 6-month follow-up. New improvements were observed on MRI at follow-up: 5 pre-existing bone marrow lesions and 3 cartilage lesions that remained unchanged immediately after the marathon reduced in their extent 6 months later. No further lesions appeared at follow-up, and the 2-week post-marathon lesions showed signs of reversibility: 10 of 18 bone marrow oedema-like signals and 3 of 21 cartilage lesions decreased on MRI. Conclusion: The knees of novice runners achieved sustained improvement, for at least 6 months post-marathon, in the condition of their bone marrow and articular cartilage.

To evaluate the short-term impact of long-distance running on knee joints using MRI. Methods 82 healthy adults participating in their first marathon underwent 3T (Tesla) MRI of both knees 6 months before and half a month after the marathon: 71 completed both the 4 month-long standardised training programme and the marathon; and 11 dropped-out during training and did not run the marathon. Two senior musculoskeletal radiologists graded the internal knee structures using validated scoring systems. Participants completed Knee Injury and Osteoarthritis Outcome Score questionnaires at each visit for self-reporting knee function. Results Premarathon and pretraining MRI showed signs of damage, without symptoms, to several knee structures in the majority of the 82 middle-aged volunteers. However, after the marathon, MRI showed a reduction in the radiological score of damage in: subchondral bone marrow oedema in the condyles of the tibia (p=0.011) and femur (p=0.082). MRI did also show an increase in radiological scores to the following structures: cartilage of the lateral patella (p=0.0005); semimembranosus tendon (p=0.016); iliotibial band (p<0.0001) and the prepatellar bursa (p=0.016). Conclusion Improvement to damaged subchondral bone of the tibial and femoral condyles was found following the marathon in novice runners, as well as worsening of the patella cartilage although asymptomatic. This is the most robust evidence to link marathon running with knee joint health and provides important information for those seeking to understand the link between long distance running and osteoarthritis of the main weight-bearing areas of the knee.

To evaluate the short-term impact of long-distance running on knee joints using MRI. Methods 82 healthy adults participating in their first marathon underwent 3T (Tesla) MRI of both knees 6 months before and half a month after the marathon: 71 completed both the 4 month-long standardised training programme and the marathon; and 11 dropped-out during training and did not run the marathon. Two senior musculoskeletal radiologists graded the internal knee structures using validated scoring systems. Participants completed Knee Injury and Osteoarthritis Outcome Score questionnaires at each visit for self-reporting knee function. Results Premarathon and pretraining MRI showed signs of damage, without symptoms, to several knee structures in the majority of the 82 middle-aged volunteers. However, after the marathon, MRI showed a reduction in the radiological score of damage in: subchondral bone marrow oedema in the condyles of the tibia (p=0.011) and femur (p=0.082). MRI did also show an increase in radiological scores to the following structures: cartilage of the lateral patella (p=0.0005); semimembranosus tendon (p=0.016); iliotibial band (p<0.0001) and the prepatellar bursa (p=0.016). Conclusion Improvement to damaged subchondral bone of the tibial and femoral condyles was found following the marathon in novice runners, as well as worsening of the patella cartilage although asymptomatic. This is the most robust evidence to link marathon running with knee joint health and provides important information for those seeking to understand the link between long distance running and osteoarthritis of the main weight-bearing areas of the knee.

Objective: To identify abnormalities in asymptomatic sedentary individuals using 3.0 Tesla high-resolution MRI. Materials and methods: The cohort comprised of 230 knees of 115 uninjured sedentary adults (51 males, 64 females; median age: 44 years). All participants had bilateral knee 3.0 T MRIs. Two senior musculoskeletal radiologists graded all intraarticular knee structures using validated scoring systems. Participants completed Knee Injury and Osteoarthritis Outcome Score questionnaires at the time of the MRI scan. Results: MRI showed abnormalities in the majority (97%) of knees. Thirty percent knees had meniscal tears: horizontal (23%), complex (3%), vertical (2%), radial (2%) and bucket handle (1%). Cartilage and bone marrow abnormalities were prevalent at the patellofemoral joint (57% knees and 48% knees, respectively). Moderate and severe cartilage lesions were common, in 19% and 31% knees, respectively, while moderate and severe bone marrow oedema in 19% and 31% knees, respectively. Moderate-intensity lesion in tendons was found in 21% knees and high-grade tendonitis in 6% knees-the patellar (11% and 2%, respectively) and quadriceps (7% and 2%, respectively) tendons being most affected. Three percent partial ligamentous ruptures were found, especially of the anterior cruciate ligament (2%). Conclusion: Nearly all knees of asymptomatic adults showed abnormalities in at least one knee structure on MRI. Meniscal tears, cartilage and bone marrow lesions of the patellofemoral joint were the most common pathological findings. Bucket handle and complex meniscal tears were reported for the first time in asymptomatic knees.

An analysis of the early tectonic history of southern Africa reveals that the intrusion is situated at the intersection of several lineaments. Based on gravity measurements the Bushveld can be divided into five subcomplexes. The differentiation trends of the magma cannot wholly account for the seams of chromitite or massive titanomagnetite layers. It is proposed, on the basis of field evidence and laboratory studies of the magnetites and chromites, that local variations in oxygen fugacity are responsible for their genesis., An analysis of the early tectonic history of southern Africa reveals that the intrusion is situated at the intersection of several lineaments. Based on gravity measurements the Bushveld can be divided into five subcomplexes. The differentiation trends of the magma cannot wholly account for the seams of chromitite or massive titanomagnetite layers. It is proposed, on the basis of field evidence and laboratory studies of the magnetites and chromites, that local variations in oxygen fugacity are responsible for their genesis.

Quam Sub Praesidio Viri ... Dn. Henrici Hulsii ... Publicae Eruditorum disquisitioni subiicit Johannes Cochius, Solinga-Montanus ..., Schlüsselseiten aus dem Exemplar der ULB Halle: Id 5971, Vorlageform des Erscheinungsvermerks: Duisburgi ad Rhenum, Apud Johannem Sas, Academiae Typographum, Anno M.DC.XCIV.

Quam Sub Praesidio Viri ... Dn. Henrici Hulsii ... Publicae Eruditorum disquisitioni subiicit Johannes Cochius, Solinga-Montanus ..., Schlüsselseiten aus dem Exemplar der ULB Halle: Id 5971, Vorlageform des Erscheinungsvermerks: Duisburgi ad Rhenum, Apud Johannem Sas, Academiae Typographum, Anno M.DC.XCIV.

M. D * * * és pseudònim de Paul Henri Thiry, Signatures: [ ]2, a-g4, A-Kkkk4, Notes a peu de p. a 2 cols., post. marg. i reclams a la fi dels quaderns, Frisos i vinyetes, Índex, Traducció de l'alemany, Text en francès i alguns fragments en italià