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9 results on '"Hilpert M"'

2. Recent changes in spoken British English according to spoken BNC2014

Author

Flach, Susanne; https://orcid.org/0000-0002-7469-2703, Hilpert, Martin, Flach, S ( Susanne ), Hilpert, M ( Martin ), Schneider, Gerold; https://orcid.org/0000-0002-1905-6237, Flach, Susanne; https://orcid.org/0000-0002-7469-2703, Hilpert, Martin, Flach, S ( Susanne ), Hilpert, M ( Martin ), and Schneider, Gerold; https://orcid.org/0000-0002-1905-6237

Abstract

Starting from a data-driven approach, the current paper compares the BNC1994 spoken to the BNC2014. We first narrow down possible research questions due to differences in the compilation and transcription of the two BNC generations. Then we investigate three robustly detectable changes at the level of lexis and morphosyntax: (1) gender and class differences, (2) the increase of be- and get-passive constructions and -ing forms from the verbal domain, and (3) the in- crease of noun compounds from the nominal domain. We also focus on the so- cial context in which linguistic changes are embedded: which noun compounds particularly increase; which words are overused by which gender or social class? Technology seems to be a driver in the further advance of the construction of noun compounds, and strong swearing seems to have decreased between 1994 and 2014.

Published
2022

3. Structural dynamics in proteins induced by and probed with X-ray free-electron laser pulses

Author

Nass, K, Gorel, A, Abdullah, MM, Martin, A, Kloos, M, Marinelli, A, Aquila, A, Barends, TRM, Decker, F-J, Doak, RB, Foucar, L, Hartmann, E, Hilpert, M, Hunter, MS, Jurek, Z, Koglin, JE, Kozlov, A, Lutman, AA, Kovacs, GN, Roome, CM, Shoeman, RL, Santra, R, Quiney, HM, Ziaja, B, Boutet, S, Schlichting, I, Nass, K, Gorel, A, Abdullah, MM, Martin, A, Kloos, M, Marinelli, A, Aquila, A, Barends, TRM, Decker, F-J, Doak, RB, Foucar, L, Hartmann, E, Hilpert, M, Hunter, MS, Jurek, Z, Koglin, JE, Kozlov, A, Lutman, AA, Kovacs, GN, Roome, CM, Shoeman, RL, Santra, R, Quiney, HM, Ziaja, B, Boutet, S, and Schlichting, I

Abstract

X-ray free-electron lasers (XFELs) enable crystallographic structure determination beyond the limitations imposed upon synchrotron measurements by radiation damage. The need for very short XFEL pulses is relieved through gating of Bragg diffraction by loss of crystalline order as damage progresses, but not if ionization events are spatially non-uniform due to underlying elemental distributions, as in biological samples. Indeed, correlated movements of iron and sulfur ions were observed in XFEL-irradiated ferredoxin microcrystals using unusually long pulses of 80 fs. Here, we report a femtosecond time-resolved X-ray pump/X-ray probe experiment on protein nanocrystals. We observe changes in the protein backbone and aromatic residues as well as disulfide bridges. Simulations show that the latter's correlated structural dynamics are much slower than expected for the predicted high atomic charge states due to significant impact of ion caging and plasma electron screening. This indicates that dense-environment effects can strongly affect local radiation damage-induced structural dynamics.

Published
2020

4. Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans

Author

Kaasinen, E. (Eevi), Kuismin, O. (Outi), Rajamäki, K. (Kristiina), Ristolainen, H. (Heikki), Aavikko, M. (Mervi), Kondelin, J. (Johanna), Saarinen, S. (Silva), Berta, D. G. (Davide G.), Katainen, R. (Riku), Hirvonen, E. A. (Elina A. M.), Karhu, A. (Auli), Taira, A. (Aurora), Tanskanen, T. (Tomas), Alkodsi, A. (Amjad), Taipale, M. (Minna), Morgunova, E. (Ekaterina), Franssila, K. (Kaarle), Lehtonen, R. (Rainer), Mäkinen, M. (Markus), Aittomäki, K. (Kristiina), Palotie, A. (Aarno), Kurki, M. I. (Mitja I.), Pietiläinen, O. (Olli), Hilpert, M. (Morgane), Saarentaus, E. (Elmo), Niinimäki, J. (Jaakko), Junttila, J. (Juhani), Kaikkonen, K. (Kari), Vahteristo, P. (Pia), Skoda, R. C. (Radek C.), Seppänen, M. R. (Mikko R. J.), Eklund, K. K. (Kari K.), Taipale, J. (Jussi), Kilpivaara, O. (Outi), Aaltonen, L. A. (Lauri A.), Kaasinen, E. (Eevi), Kuismin, O. (Outi), Rajamäki, K. (Kristiina), Ristolainen, H. (Heikki), Aavikko, M. (Mervi), Kondelin, J. (Johanna), Saarinen, S. (Silva), Berta, D. G. (Davide G.), Katainen, R. (Riku), Hirvonen, E. A. (Elina A. M.), Karhu, A. (Auli), Taira, A. (Aurora), Tanskanen, T. (Tomas), Alkodsi, A. (Amjad), Taipale, M. (Minna), Morgunova, E. (Ekaterina), Franssila, K. (Kaarle), Lehtonen, R. (Rainer), Mäkinen, M. (Markus), Aittomäki, K. (Kristiina), Palotie, A. (Aarno), Kurki, M. I. (Mitja I.), Pietiläinen, O. (Olli), Hilpert, M. (Morgane), Saarentaus, E. (Elmo), Niinimäki, J. (Jaakko), Junttila, J. (Juhani), Kaikkonen, K. (Kari), Vahteristo, P. (Pia), Skoda, R. C. (Radek C.), Seppänen, M. R. (Mikko R. J.), Eklund, K. K. (Kari K.), Taipale, J. (Jussi), Kilpivaara, O. (Outi), and Aaltonen, L. A. (Lauri A.)

Abstract

Clonal hematopoiesis driven by somatic heterozygous TET2 loss is linked to malignant degeneration via consequent aberrant DNA methylation, and possibly to cardiovascular disease via increased cytokine and chemokine expression as reported in mice. Here, we discover a germline TET2 mutation in a lymphoma family. We observe neither unusual predisposition to atherosclerosis nor abnormal pro-inflammatory cytokine or chemokine expression. The latter finding is confirmed in cells from three additional unrelated TET2 germline mutation carriers. The TET2 defect elevates blood DNA methylation levels, especially at active enhancers and cell-type specific regulatory regions with binding sequences of master transcription factors involved in hematopoiesis. The regions display reduced methylation relative to all open chromatin regions in four DNMT3A germline mutation carriers, potentially due to TET2-mediated oxidation. Our findings provide insight into the interplay between epigenetic modulators and transcription factor activity in hematological neoplasia, but do not confirm the putative role of TET2 in atherosclerosis.

Published
2019

5. Two phonological rarities in Ingrian dialects

Author

Hilpert, M., Duke, J., Mertzlufft, Ch., Östman, J.-O., Rießler, M., Kuznetsova, Natalia, Kuznetsova, Natalia (ORCID:0000-0002-3679-4717), Hilpert, M., Duke, J., Mertzlufft, Ch., Östman, J.-O., Rießler, M., Kuznetsova, Natalia, and Kuznetsova, Natalia (ORCID:0000-0002-3679-4717)

Abstract

The paper considers two typologically rare phonological phenomena related to the development of sound lengthening and reduction that appear in two dialects of the severely endangered Ingrian language in North-Western Russia. The first is attested in the Soikkola dialect, and involves a phonological ternary quantity contrast of consonants. The second exists in the Lower Luga dialect, and involves a phonological opposition of full modal and reduced voiceless vowels. First, brief phonetic, phonological and typological profiles of these contrasts are given. Furthermore, I analyze their probable further evolution against the typological background of similar phenomena in genetically related and unrelated languages. In the end, I discuss the question of stability and maintenance forces of these contrasts, as well as their significance in light of general prosodic development of the Soikkola and Lower Luga dialects.

Published
2015

6. Area formation in morphosyntax

Author

Auer, Peter, Hilpert, Martin, Stukenbrock, Anja, Szmrezcsanyi, Benedikt, Auer, P ( Peter ), Hilpert, M ( Martin ), Stukenbrock, A ( Anja ), Szmrezcsanyi, B ( Benedikt ), Glaser, Elvira; https://orcid.org/0000-0002-9620-3851, Auer, Peter, Hilpert, Martin, Stukenbrock, Anja, Szmrezcsanyi, Benedikt, Auer, P ( Peter ), Hilpert, M ( Martin ), Stukenbrock, A ( Anja ), Szmrezcsanyi, B ( Benedikt ), and Glaser, Elvira; https://orcid.org/0000-0002-9620-3851

Published
2013

7. On the interactive achievement of space – and its possible meanings

Author

Auer, Peter, Hilpert, Martin, Stukenbrock, Anja, Szmrezcsanyi, Benedikt, Auer, P ( Peter ), Hilpert, M ( Martin ), Stukenbrock, A ( Anja ), Szmrezcsanyi, B ( Benedikt ), Hausendorf, Heiko, Auer, Peter, Hilpert, Martin, Stukenbrock, Anja, Szmrezcsanyi, Benedikt, Auer, P ( Peter ), Hilpert, M ( Martin ), Stukenbrock, A ( Anja ), Szmrezcsanyi, B ( Benedikt ), and Hausendorf, Heiko

Published
2013

8. On the interactive achievement of space – and its possible meanings

Author

Auer, Peter, Hilpert, Martin, Stukenbrock, Anja, Szmrezcsanyi, Benedikt, Auer, P ( Peter ), Hilpert, M ( Martin ), Stukenbrock, A ( Anja ), Szmrezcsanyi, B ( Benedikt ), Hausendorf, Heiko, Auer, Peter, Hilpert, Martin, Stukenbrock, Anja, Szmrezcsanyi, Benedikt, Auer, P ( Peter ), Hilpert, M ( Martin ), Stukenbrock, A ( Anja ), Szmrezcsanyi, B ( Benedikt ), and Hausendorf, Heiko

Published
2013

9. Area formation in morphosyntax

Author

Auer, Peter, Hilpert, Martin, Stukenbrock, Anja, Szmrezcsanyi, Benedikt, Auer, P ( Peter ), Hilpert, M ( Martin ), Stukenbrock, A ( Anja ), Szmrezcsanyi, B ( Benedikt ), Glaser, Elvira; https://orcid.org/0000-0002-9620-3851, Auer, Peter, Hilpert, Martin, Stukenbrock, Anja, Szmrezcsanyi, Benedikt, Auer, P ( Peter ), Hilpert, M ( Martin ), Stukenbrock, A ( Anja ), Szmrezcsanyi, B ( Benedikt ), and Glaser, Elvira; https://orcid.org/0000-0002-9620-3851

Published
2013

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