Search

Two equal reliefs of an emblem with the ouroboros are carved on the cover of the Prebendados stalls in the cathedral of Granada, together with other talking elements alluding to the inexorable passage of time, death and the glory that letters or weapons grant. This work addresses various interpretations of the aforementioned emblem, establishing the graphic source in an engraving published in the “Despertar Christiano ...” by Joseph de Barcia y Zambrana from 1684., En el guardaplovo de la sillería de Prebendados de la catedral giennense, hay esculpido dos relieves iguales de un emblema con el ouroboros junto con otros elementos parlantes alusivos al paso inexorable del tiempo, la muerte y la gloria que otorga las letras o las armas Este trabajo aborda varias interpretaciones del emblema aludido, estableciendo la fuente gráfica en un grabado publicado en el “Despertar Christiano ...” de Joseph de Barcia y Zambrana del año 1684.

Two equal reliefs of an emblem with the ouroboros are carved on the cover of the Prebendados stalls in the cathedral of Granada, together with other talking elements alluding to the inexorable passage of time, death and the glory that letters or weapons grant. This work addresses various interpretations of the aforementioned emblem, establishing the graphic source in an engraving published in the “Despertar Christiano ...” by Joseph de Barcia y Zambrana from 1684., En el guardaplovo de la sillería de Prebendados de la catedral giennense, hay esculpido dos relieves iguales de un emblema con el ouroboros junto con otros elementos parlantes alusivos al paso inexorable del tiempo, la muerte y la gloria que otorga las letras o las armas Este trabajo aborda varias interpretaciones del emblema aludido, estableciendo la fuente gráfica en un grabado publicado en el “Despertar Christiano ...” de Joseph de Barcia y Zambrana del año 1684.

The spatiotemporal control of gene expression is crucial for the successful completion of animal development. The evolutionary constraints on development are particularly strong for the mid-embryonic stage when body segments are specified, as evidenced by a high degree of morphological and protein-coding gene conservation during this period--a phenomenon known as the developmental hourglass. The discovery of microRNA-mediated gene control revealed an entirely new layer of complexity of the molecular networks that orchestrate development. However, the constraints on microRNA developmental expression and evolution, and the implications for animal evolution are less well understood. To systematically explore the conservation of microRNAs during development, we carried out a genome-wide comparative study of microRNA expression levels throughout the ontogenesis of two divergent fruit flies, Drosophila melanogaster and D. virilis. We show that orthologous microRNAs display highly similar temporal profiles regardless of their mutation rates, suggesting that the timely expression of microRNA genes can be more constrained than their sequence. Furthermore, transitions between key developmental events in the different species are accompanied by conserved shifts in microRNA expression profiles, with the mid-embryonic period between gastrulation and segmentation characterized by the highest similarity of microRNA expression. The conservation of microRNA expression therefore displays an hourglass pattern similar to that observed for protein-coding genes.

The spatiotemporal control of gene expression is crucial for the successful completion of animal development. The evolutionary constraints on development are particularly strong for the mid-embryonic stage when body segments are specified, as evidenced by a high degree of morphological and protein-coding gene conservation during this period--a phenomenon known as the developmental hourglass. The discovery of microRNA-mediated gene control revealed an entirely new layer of complexity of the molecular networks that orchestrate development. However, the constraints on microRNA developmental expression and evolution, and the implications for animal evolution are less well understood. To systematically explore the conservation of microRNAs during development, we carried out a genome-wide comparative study of microRNA expression levels throughout the ontogenesis of two divergent fruit flies, Drosophila melanogaster and D. virilis. We show that orthologous microRNAs display highly similar temporal profiles regardless of their mutation rates, suggesting that the timely expression of microRNA genes can be more constrained than their sequence. Furthermore, transitions between key developmental events in the different species are accompanied by conserved shifts in microRNA expression profiles, with the mid-embryonic period between gastrulation and segmentation characterized by the highest similarity of microRNA expression. The conservation of microRNA expression therefore displays an hourglass pattern similar to that observed for protein-coding genes.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

This thesis project is the first five chapters and a summary of a fiction novel, Carol's Hourglass. After Thea's sister, Carol, commits suicide in the Rosewood Institute of The Living, she inherits all of her assets. Thea goes to Carol's apartment to empty out her belongings. As she looks through Carol's belongings, Thea finds a strange hourglass and a photo of an event that never happened: Carol's wedding. Every night she turns the hourglass and begins to have strange dreams involving a an old childhood room and a strange person who calls himself "The Umbrella Man." Thea gets caught up in her dream world and soon realizes her reality may not be what it seems.

Please note that if this image is under copyright, you may need to contact one or more copyright owners for any use that is not permitted under the ARTstor Terms and Conditions of Use or not otherwise permitted by law. While ARTstor tries to update contact information, it cannot guarantee that such information is always accurate. Determining whether those permissions are necessary, and obtaining such permissions, is your sole responsibility.

Obsahem této diplomové práce je návrh a posouzení nosné konstrukce rozhledny ležící mezi obci Horní Lhota a Provodov. Konstrukce byla navržena jako ocelová ve dvou variantách. Varianta A je tvaru kvádru s délkou strany 6,8 m a výškou 37,7 m. Varianta B je tvaru přesýpacích hodin o výšce 39 m. Půdorysem je pravidelný osmiúhelník s proměnným průměrem. Podrobný statický výpočet a výkresová dokumentace byla zpracována jen pro variantu B., The contents of this graduation thesis is design and assessment of the load-bearing structure of the observation tower situated between the village of Horni Lhota and Provodov. The construction was designed as a steel structure in two variants. Type A is cuboid shape with a side lenght ground plan 6,8 m and height of 37,7 m. Type B is an hourglass shape with a height of 39 m. Ground plan is a regular octagon shape with variable diameter. Detailed static calculation and drawing documentation was processed only for option B.

Obsahem této diplomové práce je návrh a posouzení nosné konstrukce rozhledny ležící mezi obci Horní Lhota a Provodov. Konstrukce byla navržena jako ocelová ve dvou variantách. Varianta A je tvaru kvádru s délkou strany 6,8 m a výškou 37,7 m. Varianta B je tvaru přesýpacích hodin o výšce 39 m. Půdorysem je pravidelný osmiúhelník s proměnným průměrem. Podrobný statický výpočet a výkresová dokumentace byla zpracována jen pro variantu B., The contents of this graduation thesis is design and assessment of the load-bearing structure of the observation tower situated between the village of Horni Lhota and Provodov. The construction was designed as a steel structure in two variants. Type A is cuboid shape with a side lenght ground plan 6,8 m and height of 37,7 m. Type B is an hourglass shape with a height of 39 m. Ground plan is a regular octagon shape with variable diameter. Detailed static calculation and drawing documentation was processed only for option B.