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Yijie Hua,1,* Lan Chen,1,* Chenxi Hou,2 Shengbo Liu,3 Zhichao Pei,2 Yuchao Lu1 1Analysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of China; 2College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China; 3School of Chemistry, Biology, and Material Engineering, Suzhou University of Science and Technology, Suzhou, Jiangsu 215009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuchao LuAnalysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of ChinaTel/ Fax +86 317 560 5226Email luyuchao@hebau.edu.cnZhichao PeiCollege of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of ChinaTel +86 298 709 1196Fax +86 298 709 2769Email peizc@nwafu.edu.cnAbstract: Supramolecular vesicles are the most popular smart nano-drug delivery systems (SDDs) because of their unique cavities, which have high loading carrying capacity and controlled-release action in response to specific stimuli. These vesicles are constructed from amphiphilic molecules via host-guest complexation, typically with targeted stimuli-responsive units, which are particularly important in biotechnology and biomedicine applications. Amphiphilic pillar[n]arenes, which are novel and functional macrocyclic host molecules, have been widely used to construct supramolecular vesicles because of their intrinsic rigid and symmetrical structure, electron-rich cavities and excellent properties. In this review, we first explain the synthesis of three types of amphiphilic pillar[n]arenes: neutral, anionic and cationic pilla

Yijie Hua,1,* Lan Chen,1,* Chenxi Hou,2 Shengbo Liu,3 Zhichao Pei,2 Yuchao Lu1 1Analysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of China; 2College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China; 3School of Chemistry, Biology, and Material Engineering, Suzhou University of Science and Technology, Suzhou, Jiangsu 215009, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuchao LuAnalysis Center of College of Science & Technology, Hebei Agricultural University, Huanghua, Hebei 061100, People’s Republic of ChinaTel/ Fax +86 317 560 5226Email luyuchao@hebau.edu.cnZhichao PeiCollege of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of ChinaTel +86 298 709 1196Fax +86 298 709 2769Email peizc@nwafu.edu.cnAbstract: Supramolecular vesicles are the most popular smart nano-drug delivery systems (SDDs) because of their unique cavities, which have high loading carrying capacity and controlled-release action in response to specific stimuli. These vesicles are constructed from amphiphilic molecules via host-guest complexation, typically with targeted stimuli-responsive units, which are particularly important in biotechnology and biomedicine applications. Amphiphilic pillar[n]arenes, which are novel and functional macrocyclic host molecules, have been widely used to construct supramolecular vesicles because of their intrinsic rigid and symmetrical structure, electron-rich cavities and excellent properties. In this review, we first explain the synthesis of three types of amphiphilic pillar[n]arenes: neutral, anionic and cationic pilla