Search

Your search keyword '"Isometsa, E. T."' showing total 6 results
Start Over Author "Isometsa, E. T." Database OAIster
6 results on '"Isometsa, E. T."'

1. Compulsory Admissions of patients with mental disorders: State of the art on ethical and legislative aspects in 40 European countries

Author

wasserman, D, Apter, G, Baeken, C, Bailey, Susannah Mary, Balazs, J, Bec, C, Bienkowski, P, Bobes, J, Bravo Ortiz, M F, Brunn, H, Boke, O, Camilleri, N, Carpiniello, B, Chihai, J, Chkonia, E, Courtet, P, Cozman, D, David, M, Dom, G, Esanu, A, Falkai, P, Flannery, W, Gasparyan, K, Gerlinger, G, Gorwood, P, Gudmundsson, O, Hanon, C, Heinz, A, Heitor Dos Santos, M J, Hedlund, A, Ismayilov, F, Ismayliov, N, Isometsa, E T, Izakova, L, Kleinberg, A, Kurimay, T, Klæbo Reitan, S, Lecic-Tosevski, D, Lehmets, A, Lindberg, N, Lundblad, K A, Lynch, G, Maddock, C, Malt, U F, Martin, L, Martynikhin, I, Maruta, N O, Matthys, F, Mazaliauskiene, R, Mihajlovic, G, Mihaljevic Peles, A, Miklavic, V, Mohr, P, Munarriz Ferrandis, M, Musalek, M, Neznanov, N, Ostorharics-Horvath, G, Pajević, I, Popova, A, Pregelj, P, Prinsen, N, Savenko, Y, Skugarevsky, O, Slodecki, E, Soghoyan, A, Stone, D S, Taylor-East, R, Terauds, E, Tsopelas, C, Tudose, C, Tyano, S, Vallon, P, Van der Gaag, R J, Varandas, P, Vavrusova, L, Voloshyn, P, Wancata, J, Wise, J, Zemishlany, Z, Öncü, F, Vahip, S, wasserman, D, Apter, G, Baeken, C, Bailey, Susannah Mary, Balazs, J, Bec, C, Bienkowski, P, Bobes, J, Bravo Ortiz, M F, Brunn, H, Boke, O, Camilleri, N, Carpiniello, B, Chihai, J, Chkonia, E, Courtet, P, Cozman, D, David, M, Dom, G, Esanu, A, Falkai, P, Flannery, W, Gasparyan, K, Gerlinger, G, Gorwood, P, Gudmundsson, O, Hanon, C, Heinz, A, Heitor Dos Santos, M J, Hedlund, A, Ismayilov, F, Ismayliov, N, Isometsa, E T, Izakova, L, Kleinberg, A, Kurimay, T, Klæbo Reitan, S, Lecic-Tosevski, D, Lehmets, A, Lindberg, N, Lundblad, K A, Lynch, G, Maddock, C, Malt, U F, Martin, L, Martynikhin, I, Maruta, N O, Matthys, F, Mazaliauskiene, R, Mihajlovic, G, Mihaljevic Peles, A, Miklavic, V, Mohr, P, Munarriz Ferrandis, M, Musalek, M, Neznanov, N, Ostorharics-Horvath, G, Pajević, I, Popova, A, Pregelj, P, Prinsen, N, Savenko, Y, Skugarevsky, O, Slodecki, E, Soghoyan, A, Stone, D S, Taylor-East, R, Terauds, E, Tsopelas, C, Tudose, C, Tyano, S, Vallon, P, Van der Gaag, R J, Varandas, P, Vavrusova, L, Voloshyn, P, Wancata, J, Wise, J, Zemishlany, Z, Öncü, F, and Vahip, S

Abstract

Background: Compulsory admission procedures of patients with mental disorders vary between countries in Europe. The Ethics Committee of the European Psychiatric Association (EPA) launched a survey on involuntary admission procedures of patients with mental disorders in 40 countries to gather information from all National Psychiatric Associations that are members of the EPA to develop recommendations for improving involuntary admission processes and promote voluntary care. Methods: The survey focused on legislation of involuntary admissions and key actors involved in the admission procedure as well as most common reasons for involuntary admissions. Results: We analysed the survey categorical data in themes, which highlight that both medical and legal actors are involved in involuntary admission procedures. Conclusions: We conclude that legal reasons for compulsory admission should be reworded in order to remove stigmatisation of the patient, that raising awareness about involuntary admission procedures and patient rights with both patients and family advocacy groups is paramount, that communication about procedures should be widely available in lay-language for the general population, and that training sessions and guidance should be available for legal and medical practitioners. Finally, people working in the field need to be constantly aware about the ethical challenges surrounding compulsory admissions.

Published
2020

2. Compulsory Admissions of patients with mental disorders: State of the art on ethical and legislative aspects in 40 European countries

Author

wasserman, D, Apter, G, Baeken, C, Bailey, Susannah Mary, Balazs, J, Bec, C, Bienkowski, P, Bobes, J, Bravo Ortiz, M F, Brunn, H, Boke, O, Camilleri, N, Carpiniello, B, Chihai, J, Chkonia, E, Courtet, P, Cozman, D, David, M, Dom, G, Esanu, A, Falkai, P, Flannery, W, Gasparyan, K, Gerlinger, G, Gorwood, P, Gudmundsson, O, Hanon, C, Heinz, A, Heitor Dos Santos, M J, Hedlund, A, Ismayilov, F, Ismayliov, N, Isometsa, E T, Izakova, L, Kleinberg, A, Kurimay, T, Klæbo Reitan, S, Lecic-Tosevski, D, Lehmets, A, Lindberg, N, Lundblad, K A, Lynch, G, Maddock, C, Malt, U F, Martin, L, Martynikhin, I, Maruta, N O, Matthys, F, Mazaliauskiene, R, Mihajlovic, G, Mihaljevic Peles, A, Miklavic, V, Mohr, P, Munarriz Ferrandis, M, Musalek, M, Neznanov, N, Ostorharics-Horvath, G, Pajević, I, Popova, A, Pregelj, P, Prinsen, N, Savenko, Y, Skugarevsky, O, Slodecki, E, Soghoyan, A, Stone, D S, Taylor-East, R, Terauds, E, Tsopelas, C, Tudose, C, Tyano, S, Vallon, P, Van der Gaag, R J, Varandas, P, Vavrusova, L, Voloshyn, P, Wancata, J, Wise, J, Zemishlany, Z, Öncü, F, Vahip, S, wasserman, D, Apter, G, Baeken, C, Bailey, Susannah Mary, Balazs, J, Bec, C, Bienkowski, P, Bobes, J, Bravo Ortiz, M F, Brunn, H, Boke, O, Camilleri, N, Carpiniello, B, Chihai, J, Chkonia, E, Courtet, P, Cozman, D, David, M, Dom, G, Esanu, A, Falkai, P, Flannery, W, Gasparyan, K, Gerlinger, G, Gorwood, P, Gudmundsson, O, Hanon, C, Heinz, A, Heitor Dos Santos, M J, Hedlund, A, Ismayilov, F, Ismayliov, N, Isometsa, E T, Izakova, L, Kleinberg, A, Kurimay, T, Klæbo Reitan, S, Lecic-Tosevski, D, Lehmets, A, Lindberg, N, Lundblad, K A, Lynch, G, Maddock, C, Malt, U F, Martin, L, Martynikhin, I, Maruta, N O, Matthys, F, Mazaliauskiene, R, Mihajlovic, G, Mihaljevic Peles, A, Miklavic, V, Mohr, P, Munarriz Ferrandis, M, Musalek, M, Neznanov, N, Ostorharics-Horvath, G, Pajević, I, Popova, A, Pregelj, P, Prinsen, N, Savenko, Y, Skugarevsky, O, Slodecki, E, Soghoyan, A, Stone, D S, Taylor-East, R, Terauds, E, Tsopelas, C, Tudose, C, Tyano, S, Vallon, P, Van der Gaag, R J, Varandas, P, Vavrusova, L, Voloshyn, P, Wancata, J, Wise, J, Zemishlany, Z, Öncü, F, and Vahip, S

Abstract

Background: Compulsory admission procedures of patients with mental disorders vary between countries in Europe. The Ethics Committee of the European Psychiatric Association (EPA) launched a survey on involuntary admission procedures of patients with mental disorders in 40 countries to gather information from all National Psychiatric Associations that are members of the EPA to develop recommendations for improving involuntary admission processes and promote voluntary care. Methods: The survey focused on legislation of involuntary admissions and key actors involved in the admission procedure as well as most common reasons for involuntary admissions. Results: We analysed the survey categorical data in themes, which highlight that both medical and legal actors are involved in involuntary admission procedures. Conclusions: We conclude that legal reasons for compulsory admission should be reworded in order to remove stigmatisation of the patient, that raising awareness about involuntary admission procedures and patient rights with both patients and family advocacy groups is paramount, that communication about procedures should be widely available in lay-language for the general population, and that training sessions and guidance should be available for legal and medical practitioners. Finally, people working in the field need to be constantly aware about the ethical challenges surrounding compulsory admissions.

Published
2020

3. Compulsory Admissions of patients with mental disorders: State of the art on ethical and legislative aspects in 40 European countries

Author

wasserman, D, Apter, G, Baeken, C, Bailey, Susannah Mary, Balazs, J, Bec, C, Bienkowski, P, Bobes, J, Bravo Ortiz, M F, Brunn, H, Boke, O, Camilleri, N, Carpiniello, B, Chihai, J, Chkonia, E, Courtet, P, Cozman, D, David, M, Dom, G, Esanu, A, Falkai, P, Flannery, W, Gasparyan, K, Gerlinger, G, Gorwood, P, Gudmundsson, O, Hanon, C, Heinz, A, Heitor Dos Santos, M J, Hedlund, A, Ismayilov, F, Ismayliov, N, Isometsa, E T, Izakova, L, Kleinberg, A, Kurimay, T, Klæbo Reitan, S, Lecic-Tosevski, D, Lehmets, A, Lindberg, N, Lundblad, K A, Lynch, G, Maddock, C, Malt, U F, Martin, L, Martynikhin, I, Maruta, N O, Matthys, F, Mazaliauskiene, R, Mihajlovic, G, Mihaljevic Peles, A, Miklavic, V, Mohr, P, Munarriz Ferrandis, M, Musalek, M, Neznanov, N, Ostorharics-Horvath, G, Pajević, I, Popova, A, Pregelj, P, Prinsen, N, Savenko, Y, Skugarevsky, O, Slodecki, E, Soghoyan, A, Stone, D S, Taylor-East, R, Terauds, E, Tsopelas, C, Tudose, C, Tyano, S, Vallon, P, Van der Gaag, R J, Varandas, P, Vavrusova, L, Voloshyn, P, Wancata, J, Wise, J, Zemishlany, Z, Öncü, F, Vahip, S, wasserman, D, Apter, G, Baeken, C, Bailey, Susannah Mary, Balazs, J, Bec, C, Bienkowski, P, Bobes, J, Bravo Ortiz, M F, Brunn, H, Boke, O, Camilleri, N, Carpiniello, B, Chihai, J, Chkonia, E, Courtet, P, Cozman, D, David, M, Dom, G, Esanu, A, Falkai, P, Flannery, W, Gasparyan, K, Gerlinger, G, Gorwood, P, Gudmundsson, O, Hanon, C, Heinz, A, Heitor Dos Santos, M J, Hedlund, A, Ismayilov, F, Ismayliov, N, Isometsa, E T, Izakova, L, Kleinberg, A, Kurimay, T, Klæbo Reitan, S, Lecic-Tosevski, D, Lehmets, A, Lindberg, N, Lundblad, K A, Lynch, G, Maddock, C, Malt, U F, Martin, L, Martynikhin, I, Maruta, N O, Matthys, F, Mazaliauskiene, R, Mihajlovic, G, Mihaljevic Peles, A, Miklavic, V, Mohr, P, Munarriz Ferrandis, M, Musalek, M, Neznanov, N, Ostorharics-Horvath, G, Pajević, I, Popova, A, Pregelj, P, Prinsen, N, Savenko, Y, Skugarevsky, O, Slodecki, E, Soghoyan, A, Stone, D S, Taylor-East, R, Terauds, E, Tsopelas, C, Tudose, C, Tyano, S, Vallon, P, Van der Gaag, R J, Varandas, P, Vavrusova, L, Voloshyn, P, Wancata, J, Wise, J, Zemishlany, Z, Öncü, F, and Vahip, S

Abstract

Background: Compulsory admission procedures of patients with mental disorders vary between countries in Europe. The Ethics Committee of the European Psychiatric Association (EPA) launched a survey on involuntary admission procedures of patients with mental disorders in 40 countries to gather information from all National Psychiatric Associations that are members of the EPA to develop recommendations for improving involuntary admission processes and promote voluntary care. Methods: The survey focused on legislation of involuntary admissions and key actors involved in the admission procedure as well as most common reasons for involuntary admissions. Results: We analysed the survey categorical data in themes, which highlight that both medical and legal actors are involved in involuntary admission procedures. Conclusions: We conclude that legal reasons for compulsory admission should be reworded in order to remove stigmatisation of the patient, that raising awareness about involuntary admission procedures and patient rights with both patients and family advocacy groups is paramount, that communication about procedures should be widely available in lay-language for the general population, and that training sessions and guidance should be available for legal and medical practitioners. Finally, people working in the field need to be constantly aware about the ethical challenges surrounding compulsory admissions.

Published
2020

4. Compulsory Admissions of patients with mental disorders: State of the art on ethical and legislative aspects in 40 European countries

Author

wasserman, D, Apter, G, Baeken, C, Bailey, Susannah Mary, Balazs, J, Bec, C, Bienkowski, P, Bobes, J, Bravo Ortiz, M F, Brunn, H, Boke, O, Camilleri, N, Carpiniello, B, Chihai, J, Chkonia, E, Courtet, P, Cozman, D, David, M, Dom, G, Esanu, A, Falkai, P, Flannery, W, Gasparyan, K, Gerlinger, G, Gorwood, P, Gudmundsson, O, Hanon, C, Heinz, A, Heitor Dos Santos, M J, Hedlund, A, Ismayilov, F, Ismayliov, N, Isometsa, E T, Izakova, L, Kleinberg, A, Kurimay, T, Klæbo Reitan, S, Lecic-Tosevski, D, Lehmets, A, Lindberg, N, Lundblad, K A, Lynch, G, Maddock, C, Malt, U F, Martin, L, Martynikhin, I, Maruta, N O, Matthys, F, Mazaliauskiene, R, Mihajlovic, G, Mihaljevic Peles, A, Miklavic, V, Mohr, P, Munarriz Ferrandis, M, Musalek, M, Neznanov, N, Ostorharics-Horvath, G, Pajević, I, Popova, A, Pregelj, P, Prinsen, N, Savenko, Y, Skugarevsky, O, Slodecki, E, Soghoyan, A, Stone, D S, Taylor-East, R, Terauds, E, Tsopelas, C, Tudose, C, Tyano, S, Vallon, P, Van der Gaag, R J, Varandas, P, Vavrusova, L, Voloshyn, P, Wancata, J, Wise, J, Zemishlany, Z, Öncü, F, Vahip, S, wasserman, D, Apter, G, Baeken, C, Bailey, Susannah Mary, Balazs, J, Bec, C, Bienkowski, P, Bobes, J, Bravo Ortiz, M F, Brunn, H, Boke, O, Camilleri, N, Carpiniello, B, Chihai, J, Chkonia, E, Courtet, P, Cozman, D, David, M, Dom, G, Esanu, A, Falkai, P, Flannery, W, Gasparyan, K, Gerlinger, G, Gorwood, P, Gudmundsson, O, Hanon, C, Heinz, A, Heitor Dos Santos, M J, Hedlund, A, Ismayilov, F, Ismayliov, N, Isometsa, E T, Izakova, L, Kleinberg, A, Kurimay, T, Klæbo Reitan, S, Lecic-Tosevski, D, Lehmets, A, Lindberg, N, Lundblad, K A, Lynch, G, Maddock, C, Malt, U F, Martin, L, Martynikhin, I, Maruta, N O, Matthys, F, Mazaliauskiene, R, Mihajlovic, G, Mihaljevic Peles, A, Miklavic, V, Mohr, P, Munarriz Ferrandis, M, Musalek, M, Neznanov, N, Ostorharics-Horvath, G, Pajević, I, Popova, A, Pregelj, P, Prinsen, N, Savenko, Y, Skugarevsky, O, Slodecki, E, Soghoyan, A, Stone, D S, Taylor-East, R, Terauds, E, Tsopelas, C, Tudose, C, Tyano, S, Vallon, P, Van der Gaag, R J, Varandas, P, Vavrusova, L, Voloshyn, P, Wancata, J, Wise, J, Zemishlany, Z, Öncü, F, and Vahip, S

Abstract

Background: Compulsory admission procedures of patients with mental disorders vary between countries in Europe. The Ethics Committee of the European Psychiatric Association (EPA) launched a survey on involuntary admission procedures of patients with mental disorders in 40 countries to gather information from all National Psychiatric Associations that are members of the EPA to develop recommendations for improving involuntary admission processes and promote voluntary care. Methods: The survey focused on legislation of involuntary admissions and key actors involved in the admission procedure as well as most common reasons for involuntary admissions. Results: We analysed the survey categorical data in themes, which highlight that both medical and legal actors are involved in involuntary admission procedures. Conclusions: We conclude that legal reasons for compulsory admission should be reworded in order to remove stigmatisation of the patient, that raising awareness about involuntary admission procedures and patient rights with both patients and family advocacy groups is paramount, that communication about procedures should be widely available in lay-language for the general population, and that training sessions and guidance should be available for legal and medical practitioners. Finally, people working in the field need to be constantly aware about the ethical challenges surrounding compulsory admissions.

Published
2020

5. Influence of birth cohort on age of onset cluster analysis in bipolar I disorder

Author

Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., Baethge, C., Bauer, R., Bellivier, F., Belmaker, R. H., Berk, M., Bjella, T. D., Bossini, L., Bersudsky, Y., Cheung, E. Y. W., Conell, J., Del Zompo, M., Dodd, S., Etain, B., Fagiolini, A., Frye, M. A., Fountoulakis, K. N., Garneau-Fournier, J., Gonzalez-Pinto, A., Harima, H., Hassel, S., Henry, C., Iacovides, A., Isometsa, E. T., Kapczinski, F., Kliwicki, S., Koenig, B., Krogh, R., Kunz, M., Lafer, B., Larsen, E. R., Lewitzka, U., Lopez-Jaramillo, C., MacQueen, G., Manchia, M., Marsh, W., Martinez-Cengotitabengoa, M., Melle, I., Monteith, S., Morken, G., Munoz, R., Nery, F. G., O'Donovan, C., Osher, Y., Pfennig, A., Quiroz, D., Ramesar, R., Rasgon, N., Reif, A., Ritter, P., Rybakowski, J. K., Sagduyu, K., Scippa, A. M., Severus, E., Simhandl, C., Stein, D. J., Strejilevich, S., Sulaiman, A. Hatim, Suominen, K., Tagata, H., Tatebayashi, Y., Torrent, C., Vieta, E., Viswanath, B., Wanchoo, M. J., Zetin, M., Whybrow, P. C., Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., Baethge, C., Bauer, R., Bellivier, F., Belmaker, R. H., Berk, M., Bjella, T. D., Bossini, L., Bersudsky, Y., Cheung, E. Y. W., Conell, J., Del Zompo, M., Dodd, S., Etain, B., Fagiolini, A., Frye, M. A., Fountoulakis, K. N., Garneau-Fournier, J., Gonzalez-Pinto, A., Harima, H., Hassel, S., Henry, C., Iacovides, A., Isometsa, E. T., Kapczinski, F., Kliwicki, S., Koenig, B., Krogh, R., Kunz, M., Lafer, B., Larsen, E. R., Lewitzka, U., Lopez-Jaramillo, C., MacQueen, G., Manchia, M., Marsh, W., Martinez-Cengotitabengoa, M., Melle, I., Monteith, S., Morken, G., Munoz, R., Nery, F. G., O'Donovan, C., Osher, Y., Pfennig, A., Quiroz, D., Ramesar, R., Rasgon, N., Reif, A., Ritter, P., Rybakowski, J. K., Sagduyu, K., Scippa, A. M., Severus, E., Simhandl, C., Stein, D. J., Strejilevich, S., Sulaiman, A. Hatim, Suominen, K., Tagata, H., Tatebayashi, Y., Torrent, C., Vieta, E., Viswanath, B., Wanchoo, M. J., Zetin, M., and Whybrow, P. C.

Abstract

Purpose: Two common approaches to identify subgroups of patients with bipolar disorder are clustering methodology (mixture analysis) based on the age of onset, and a birth cohort analysis. This study investigates if a birth cohort effect will influence the results of clustering on the age of onset, using a large, international database. Methods: The database includes 4037 patients with a diagnosis of bipolar I disorder, previously collected at 36 collection sites in 23 countries. Generalized estimating equations (GEE) were used to adjust the data for country median age, and in some models, birth cohort. Model-based clustering (mixture analysis) was then performed on the age of onset data using the residuals. Clinical variables in subgroups were compared. Results: There was a strong birth cohort effect. Without adjusting for the birth cohort, three subgroups were found by clustering. After adjusting for the birth cohort or when considering only those born after 1959, two subgroups were found. With results of either two or three subgroups, the youngest subgroup was more likely to have a family history of mood disorders and a first episode with depressed polarity. However, without adjusting for birth cohort (three subgroups), family history and polarity of the first episode could not be distinguished between the middle and oldest subgroups. Conclusion: These results using international data confirm prior findings using single country data, that there are subgroups of bipolar I disorder based on the age of onset, and that there is a birth cohort effect. Including the birth cohort adjustment altered the number and characteristics of subgroups detected when clustering by age of onset. Further investigation is needed to determine if combining both approaches will identify subgroups that are more useful for research. (C) 2014 Elsevier Masson SAS. All rights reserved.

Published
2015

6. Influence of birth cohort on age of onset cluster analysis in bipolar I disorder

Author

Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., Baethge, C., Bauer, R., Bellivier, F., Belmaker, R. H., Berk, M., Bjella, T. D., Bossini, L., Bersudsky, Y., Cheung, E. Y. W., Conell, J., Del Zompo, M., Dodd, S., Etain, B., Fagiolini, A., Frye, M. A., Fountoulakis, K. N., Garneau-Fournier, J., Gonzalez-Pinto, A., Harima, H., Hassel, S., Henry, C., Iacovides, A., Isometsa, E. T., Kapczinski, F., Kliwicki, S., Koenig, B., Krogh, R., Kunz, M., Lafer, B., Larsen, E. R., Lewitzka, U., Lopez-Jaramillo, C., MacQueen, G., Manchia, M., Marsh, W., Martinez-Cengotitabengoa, M., Melle, I., Monteith, S., Morken, G., Munoz, R., Nery, F. G., O'Donovan, C., Osher, Y., Pfennig, A., Quiroz, D., Ramesar, R., Rasgon, N., Reif, A., Ritter, P., Rybakowski, J. K., Sagduyu, K., Scippa, A. M., Severus, E., Simhandl, C., Stein, D. J., Strejilevich, S., Sulaiman, A. Hatim, Suominen, K., Tagata, H., Tatebayashi, Y., Torrent, C., Vieta, E., Viswanath, B., Wanchoo, M. J., Zetin, M., Whybrow, P. C., Bauer, M., Glenn, T., Alda, M., Andreassen, O. A., Angelopoulos, E., Ardau, R., Baethge, C., Bauer, R., Bellivier, F., Belmaker, R. H., Berk, M., Bjella, T. D., Bossini, L., Bersudsky, Y., Cheung, E. Y. W., Conell, J., Del Zompo, M., Dodd, S., Etain, B., Fagiolini, A., Frye, M. A., Fountoulakis, K. N., Garneau-Fournier, J., Gonzalez-Pinto, A., Harima, H., Hassel, S., Henry, C., Iacovides, A., Isometsa, E. T., Kapczinski, F., Kliwicki, S., Koenig, B., Krogh, R., Kunz, M., Lafer, B., Larsen, E. R., Lewitzka, U., Lopez-Jaramillo, C., MacQueen, G., Manchia, M., Marsh, W., Martinez-Cengotitabengoa, M., Melle, I., Monteith, S., Morken, G., Munoz, R., Nery, F. G., O'Donovan, C., Osher, Y., Pfennig, A., Quiroz, D., Ramesar, R., Rasgon, N., Reif, A., Ritter, P., Rybakowski, J. K., Sagduyu, K., Scippa, A. M., Severus, E., Simhandl, C., Stein, D. J., Strejilevich, S., Sulaiman, A. Hatim, Suominen, K., Tagata, H., Tatebayashi, Y., Torrent, C., Vieta, E., Viswanath, B., Wanchoo, M. J., Zetin, M., and Whybrow, P. C.

Abstract

Purpose: Two common approaches to identify subgroups of patients with bipolar disorder are clustering methodology (mixture analysis) based on the age of onset, and a birth cohort analysis. This study investigates if a birth cohort effect will influence the results of clustering on the age of onset, using a large, international database. Methods: The database includes 4037 patients with a diagnosis of bipolar I disorder, previously collected at 36 collection sites in 23 countries. Generalized estimating equations (GEE) were used to adjust the data for country median age, and in some models, birth cohort. Model-based clustering (mixture analysis) was then performed on the age of onset data using the residuals. Clinical variables in subgroups were compared. Results: There was a strong birth cohort effect. Without adjusting for the birth cohort, three subgroups were found by clustering. After adjusting for the birth cohort or when considering only those born after 1959, two subgroups were found. With results of either two or three subgroups, the youngest subgroup was more likely to have a family history of mood disorders and a first episode with depressed polarity. However, without adjusting for birth cohort (three subgroups), family history and polarity of the first episode could not be distinguished between the middle and oldest subgroups. Conclusion: These results using international data confirm prior findings using single country data, that there are subgroups of bipolar I disorder based on the age of onset, and that there is a birth cohort effect. Including the birth cohort adjustment altered the number and characteristics of subgroups detected when clustering by age of onset. Further investigation is needed to determine if combining both approaches will identify subgroups that are more useful for research. (C) 2014 Elsevier Masson SAS. All rights reserved.

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results