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1. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author: Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, Morgan, Linda, Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, and Morgan, Linda
Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Published: 2020

2. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author: Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, Morgan, Linda, Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, and Morgan, Linda
Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Published: 2020

3. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author: Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, Morgan, Linda, Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, and Morgan, Linda
Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Published: 2020

4. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author: Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, Morgan, Linda, Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, and Morgan, Linda
Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Published: 2020

5. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author: Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, Morgan, Linda, Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, and Morgan, Linda
Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Published: 2020

6. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author: Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, Morgan, Linda, Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria-Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Poston, Lucilla, Prescott, Gordon, Saevarsdottir, Saedis, Salimbayeva, Damilya, Scaife, Paula Juliet, Skotte, Line, Staines-Urias, Eleonora, Stefansson, Olafur A., Sørensen, Karina Meden, Thomsen, Liv Cecilie Vestrheim, Tragante, Vinicius, Trogstad, Lill, Simpson, Nigel A. B., Aripova, Tamara, Casas, Juan P., Dominiczak, Anna F., Walker, James J., Thorsteinsdottir, Unnur, Iversen, Ann-Charlotte, Feenstra, Bjarke, Lawlor, Deborah A., Boyd, Heather Allison, Magnus, Per, Laivuori, Hannele, Zakhidova, Nodira, Svyatova, Gulnara, Stefansson, Kari, and Morgan, Linda
Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Published: 2020

7. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author: Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Skotte, Line, Sørensen, Karina Meden, Kere, Juha, Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Skotte, Line, Sørensen, Karina Meden, and Kere, Juha
Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Published: 2020

8. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

Author: Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Skotte, Line, Sørensen, Karina Meden, Kere, Juha, Steinthorsdottir, Valgerdur, McGinnis, Ralph, Williams, Nicholas O., Stefansdottir, Lilja, Thorleifsson, Gudmar, Shooter, Scott, Fadista, João, Sigurdsson, Jon K., Auro, Kirsi M., Berezina, Galina, Borges, Maria Carolina, Bumpstead, Suzannah, Bybjerg-Grauholm, Jonas, Colgiu, Irina, Dolby, Vivien A., Dudbridge, Frank, Engel, Stephanie M., Franklin, Christopher S., Frigge, Michael L., Frisbaek, Yr, Geirsson, Reynir T., Geller, Frank, Gretarsdottir, Solveig, Gudbjartsson, Daniel F., Harmon, Quaker, Hougaard, David Michael, Hegay, Tatyana, Helgadottir, Anna, Hjartardottir, Sigrun, Jääskeläinen, Tiina, Johannsdottir, Hrefna, Jonsdottir, Ingileif, Juliusdottir, Thorhildur, Kalsheker, Noor, Kasimov, Abdumadjit, Kemp, John P., Kivinen, Katja, Klungsøyr, Kari, Lee, Wai K., Melbye, Mads, Miedzybrodska, Zosia, Moffett, Ashley, Najmutdinova, Dilbar, Nishanova, Firuza, Olafsdottir, Thorunn, Perola, Markus, Pipkin, Fiona Broughton, Skotte, Line, Sørensen, Karina Meden, and Kere, Juha
Abstract: Preeclampsia is a serious complication of pregnancy, affecting both maternal and fetal health. In genome-wide association meta-analysis of European and Central Asian mothers, we identify sequence variants that associate with preeclampsia in the maternal genome at ZNF831/20q13 and FTO/16q12. These are previously established variants for blood pressure (BP) and the FTO variant has also been associated with body mass index (BMI). Further analysis of BP variants establishes that variants at MECOM/3q26, FGF5/4q21 and SH2B3/12q24 also associate with preeclampsia through the maternal genome. We further show that a polygenic risk score for hypertension associates with preeclampsia. However, comparison with gestational hypertension indicates that additional factors modify the risk of preeclampsia.
Published: 2020

9. Why conserve biodiversity? A multi-national exploration of stakeholders views on the arguments for biodiversity conservation

Author: Berry, Pam, Fabok, Veronika, Blicharska, Malgorzata, Bredin, Yennie, Garcia-Llorente, Marina, Kovacs, Eszter, Gaemana, Nicoleta, Stanciu, Adina, Termansen, Mette, Jääskeläinen, Tiina, Haslett, John R., Harrison, Paula A., Berry, Pam, Fabok, Veronika, Blicharska, Malgorzata, Bredin, Yennie, Garcia-Llorente, Marina, Kovacs, Eszter, Gaemana, Nicoleta, Stanciu, Adina, Termansen, Mette, Jääskeläinen, Tiina, Haslett, John R., and Harrison, Paula A.
Published: 2018
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10. Caught between personal and collective values : biodiversity conservation in European decision-making

Author: Primmer, Eeva, Termansen, Mette, Bredin, Yennie, Blicharska, Malgorzata, Garcia-Llorente, Marina, Berry, Pam, Jääskeläinen, Tiina, Bela, Györgyi, Fabok, Veronika, Geamana, Nicoleta, Harrison, Paula A., Haslett, John R., Cosor, Georgia Lavinia, Andersen, Anne H.K., Primmer, Eeva, Termansen, Mette, Bredin, Yennie, Blicharska, Malgorzata, Garcia-Llorente, Marina, Berry, Pam, Jääskeläinen, Tiina, Bela, Györgyi, Fabok, Veronika, Geamana, Nicoleta, Harrison, Paula A., Haslett, John R., Cosor, Georgia Lavinia, and Andersen, Anne H.K.
Abstract: Individual decision-makers at different governance levels operate in social contexts, which means that they sometimes need to compromise their personal values. Yet, this dissonance is rarely the direct target of empirical analyses of environmental decision-making. We undertake a Q-analysis of decision-makers' personal perspectives and the perspectives they perceive to dominate in their decision-making contexts. Our empirical analysis addresses biodiversity conservation, which has traditionally been justified with intrinsic value- and science-based arguments. The arguments have recently been broadened with the concept of ecosystem services, highlighting human benefits and values. This evolving context is interesting because of the new rise of anthropocentric values, which can lead to decision-makers experiencing dissonance. Our analysis of interviews with 43 biodiversity conservation decision-makers from nine European countries reveals four personally held perspectives that highlight different, yet partly overlapping, values – intrinsic, human benefit, conservation and connection – as well as three perspectives perceived to dominate in decision-making – utilitarian, insurance and knowledge values. The comparison of personally held and perceived dominant perspectives points to one major conflict: those decision-makers who personally associate with intrinsic values and perceive utilitarian values to dominate in decision-making experience dissonance. By contrast, personally held human benefit values are accommodated well in decision-making contexts and decision-makers who perceive insurance values to dominate experience the least conflict with personally held values. These findings demonstrate the potential of arguments stressing long-term benefits for easing tension and conflicts in conservation decision-making, and the usefulness of empirically testing of the coincidence of individual and social values.
Published: 2017
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11. Caught between personal and collective values: biodiversity conservation in European decision-making

Author: Primmer, Eeva, Termansen, Mette, Bredin, Yennie, Blicharska, Malgorzata, García-Llorente, Marina, Berry, Pam, Jääskeläinen, Tiina, Bela, Györgyi, Fabok, Veronika, Geamana, Nicoleta, Harrison, Paula A., Haslett, John R., Cosor, Georgia Lavinia, Andersen, Anne H.K., Primmer, Eeva, Termansen, Mette, Bredin, Yennie, Blicharska, Malgorzata, García-Llorente, Marina, Berry, Pam, Jääskeläinen, Tiina, Bela, Györgyi, Fabok, Veronika, Geamana, Nicoleta, Harrison, Paula A., Haslett, John R., Cosor, Georgia Lavinia, and Andersen, Anne H.K.
Abstract: Individual decision-makers at different governance levels operate in social contexts, which means that they sometimes need to compromise their personal values. Yet, this dissonance is rarely the direct target of empirical analyses of environmental decision-making. We undertake a Q-analysis of decision-makers' personal perspectives and the perspectives they perceive to dominate in their decision-making contexts. Our empirical analysis addresses biodiversity conservation, which has traditionally been justified with intrinsic value- and science-based arguments. The arguments have recently been broadened with the concept of ecosystem services, highlighting human benefits and values. This evolving context is interesting because of the new rise of anthropocentric values, which can lead to decision-makers experiencing dissonance. Our analysis of interviews with 43 biodiversity conservation decision-makers from nine European countries reveals four personally held perspectives that highlight different, yet partly overlapping, values – intrinsic, human benefit, conservation and connection – as well as three perspectives perceived to dominate in decision-making – utilitarian, insurance and knowledge values. The comparison of personally held and perceived dominant perspectives points to one major conflict: those decision-makers who personally associate with intrinsic values and perceive utilitarian values to dominate in decision-making experience dissonance. By contrast, personally held human benefit values are accommodated well in decision-making contexts and decision-makers who perceive insurance values to dominate experience the least conflict with personally held values. These findings demonstrate the potential of arguments stressing long-term benefits for easing tension and conflicts in conservation decision-making, and the usefulness of empirically testing of the coincidence of individual and social values.
Published: 2017

12. Caught between personal and collective values: biodiversity conservation in European decision-making

Author: Primmer, Eeva, Termansen, Mette, Bredin, Yennie, Blicharska, Malgorzata, García-Llorente, Marina, Berry, Pam, Jääskeläinen, Tiina, Bela, Györgyi, Fabok, Veronika, Geamana, Nicoleta, Harrison, Paula A., Haslett, John R., Cosor, Georgia Lavinia, Andersen, Anne H.K., Primmer, Eeva, Termansen, Mette, Bredin, Yennie, Blicharska, Malgorzata, García-Llorente, Marina, Berry, Pam, Jääskeläinen, Tiina, Bela, Györgyi, Fabok, Veronika, Geamana, Nicoleta, Harrison, Paula A., Haslett, John R., Cosor, Georgia Lavinia, and Andersen, Anne H.K.
Abstract: Individual decision-makers at different governance levels operate in social contexts, which means that they sometimes need to compromise their personal values. Yet, this dissonance is rarely the direct target of empirical analyses of environmental decision-making. We undertake a Q-analysis of decision-makers' personal perspectives and the perspectives they perceive to dominate in their decision-making contexts. Our empirical analysis addresses biodiversity conservation, which has traditionally been justified with intrinsic value- and science-based arguments. The arguments have recently been broadened with the concept of ecosystem services, highlighting human benefits and values. This evolving context is interesting because of the new rise of anthropocentric values, which can lead to decision-makers experiencing dissonance. Our analysis of interviews with 43 biodiversity conservation decision-makers from nine European countries reveals four personally held perspectives that highlight different, yet partly overlapping, values – intrinsic, human benefit, conservation and connection – as well as three perspectives perceived to dominate in decision-making – utilitarian, insurance and knowledge values. The comparison of personally held and perceived dominant perspectives points to one major conflict: those decision-makers who personally associate with intrinsic values and perceive utilitarian values to dominate in decision-making experience dissonance. By contrast, personally held human benefit values are accommodated well in decision-making contexts and decision-makers who perceive insurance values to dominate experience the least conflict with personally held values. These findings demonstrate the potential of arguments stressing long-term benefits for easing tension and conflicts in conservation decision-making, and the usefulness of empirically testing of the coincidence of individual and social values.
Published: 2017

13. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

Author: Qi, Qibin, Kilpeläinen, Tuomas O., Downer, Mary K., Tanaka, Toshiko, Smith, Caren E., Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y., Renström, Frida, Lin, Xiaochen, Ängquist, Lars H., Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarunveer Singh, Boer, Jolanda M.A., Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H.M., Holloway, John W., Houston, Denise K., Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A., Jääskeläinen, Tiina, Lee, Nanette R., Lehtimäki, Terho, Lemaitre, Rozenn N., Lu, Wei, Luben, Robert N., Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L., Ngwa, Julius S., Perusse, Louis, van Rooij, Frank J.A., Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K., Zhu, Jingwen, Borecki, Ingrid B., Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V., Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G., Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K., Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T., Uitterlinden, André G., Zillikens, M. Carola, Franco, Oscar H., Shyong Tai, E., Ou Shu, Xiao, Siscovick, David S., Toft, Ulla, Verschuren, W.M. Monique, Vollenweider, Peter, Wareham, Nicholas J., Witteman, Jacqueline C.M., Zheng, Wei, Ridker, Paul M., Kang, Jae H., Liang, Liming, Jensen, Majken K., Curhan, Gary C., Pasquale, Louis R., Hunter, David J., Mohlke, Karen L., Uusitupa, Matti, Cupples, L. Adrienne, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I., Franks, Paul W., Sørensen, Thorkild I.A., Hu, Frank B., Loos, Ruth J. F., Nettleton, Jennifer A., Qi, Lu, Qi, Qibin, Kilpeläinen, Tuomas O., Downer, Mary K., Tanaka, Toshiko, Smith, Caren E., Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y., Renström, Frida, Lin, Xiaochen, Ängquist, Lars H., Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarunveer Singh, Boer, Jolanda M.A., Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H.M., Holloway, John W., Houston, Denise K., Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A., Jääskeläinen, Tiina, Lee, Nanette R., Lehtimäki, Terho, Lemaitre, Rozenn N., Lu, Wei, Luben, Robert N., Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L., Ngwa, Julius S., Perusse, Louis, van Rooij, Frank J.A., Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K., Zhu, Jingwen, Borecki, Ingrid B., Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V., Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G., Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K., Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T., Uitterlinden, André G., Zillikens, M. Carola, Franco, Oscar H., Shyong Tai, E., Ou Shu, Xiao, Siscovick, David S., Toft, Ulla, Verschuren, W.M. Monique, Vollenweider, Peter, Wareham, Nicholas J., Witteman, Jacqueline C.M., Zheng, Wei, Ridker, Paul M., Kang, Jae H., Liang, Liming, Jensen, Majken K., Curhan, Gary C., Pasquale, Louis R., Hunter, David J., Mohlke, Karen L., Uusitupa, Matti, Cupples, L. Adrienne, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I., Franks, Paul W., Sørensen, Thorkild I.A., Hu, Frank B., Loos, Ruth J. F., Nettleton, Jennifer A., and Qi, Lu
Abstract: FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m2, P = 1.9 × 10−105), and all participants (0.30 [0.30, 0.35] kg/m2, P = 3.6 × 10−107). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10−16), and relative weak associations with lower total energy intake (−6.4 [−10.1, −2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (−0.07 [−0.11, −0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10−9) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity
Published: 2017

14. The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort

Author: University of Helsinki, Medicum, University of Helsinki, Clinicum, University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Research Programs Unit, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Kallela, Jenni, Jääskeläinen, Tiina, Kortelainen, Eija, Heinonen, Seppo, Kajantie, Eero, Kere, Juha, Kivinen, Katja, Pouta, Anneli, Laivuori, Hannele, University of Helsinki, Medicum, University of Helsinki, Clinicum, University of Helsinki, Hospital for Children and Adolescents, University of Helsinki, Research Programs Unit, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Kallela, Jenni, Jääskeläinen, Tiina, Kortelainen, Eija, Heinonen, Seppo, Kajantie, Eero, Kere, Juha, Kivinen, Katja, Pouta, Anneli, and Laivuori, Hannele
Abstract: Background: The Finnish Pre-eclampsia Consortium (FINNPEC) case-control cohort consisting of 1447 pre-eclamptic and 1068 non-pre-eclamptic women was recruited during 2008-2011 to study genetic background of pre-eclampsia and foetal growth. Pre-eclampsia was defined by hypertension and proteinuria according to the American College of Obstetricians and Gynecologists (ACOG) 2002 classification. The ACOG Task Force Report on Hypertension in Pregnancy (2013) and The International Society for the Study of Hypertension in Pregnancy (ISSHP) (2014) have published new classifications, in which proteinuria is not necessary for diagnosis when specific symptoms are present. For diagnoses based on proteinuria, the ISSHP 2014 criteria raised its threshold to 2+ on dipstick. We studied how the new classifications would affect pre-eclampsia diagnoses in the FINNPEC cohort. Methods: We re-evaluated pre-eclampsia diagnosis using the ACOG 2013 and the ISSHP 2014 classifications in pre-eclamptic women whose proteinuria did not exceed 1+ on dipstick (n = 68), in women with gestational hypertension (n = 138) and in women with chronic hypertension (n = 66). Results: The number of women with pre-eclampsia increased 0.8 % (1459/1447) according to the ACOG 2013 criteria and 0.6 % (1455/1447) according to the ISSHP 2014 criteria. All 68 women with the amount of proteinuria not exceeding 1+ on dipstick diagnosed originally pre-eclamptic met the ACOG 2013 criteria but only 20 women (29.4 %) met the ISSHP 2014 criteria. Seven (5.1 %) and 35 (25.4 %) women with gestational hypertension were diagnosed with pre-eclampsia according to the ACOG 2013 and the ISSHP 2014 criteria, respectively. Correspondingly five (7.6 %) and 21 (31.8 %) women with chronic hypertension were diagnosed with pre-eclampsia according to the ACOG 2 013 and the ISSHP 2014 criteria. Conclusions: Only minor changes were observed in the total number of pre-eclamptic women in the FINNPEC cohort when comparing the ACOC 2002 classif
Published: 2016

15. The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort

Author: Helsingin yliopisto, Lääketieteellinen tiedekunta, University of Helsinki, Faculty of Medicine, Helsingfors universitet, Medicinska fakulteten, Kallela, Jenni, Jääskeläinen, Tiina, Kortelainen, Eija, Laivuori, Hannele, Helsingin yliopisto, Lääketieteellinen tiedekunta, University of Helsinki, Faculty of Medicine, Helsingfors universitet, Medicinska fakulteten, Kallela, Jenni, Jääskeläinen, Tiina, Kortelainen, Eija, and Laivuori, Hannele
Abstract: Background The Finnish Pre-eclampsia Consortium (FINNPEC) case-control cohort consisting of 1447 pre-eclamptic and 1068 non-pre-eclamptic women was recruited at the five Finnish university hospitals to study genetic background of pre-eclampsia and fetal growth. Pre-eclampsia was defined by hypertension and proteinuria according to the modified The American College of Obstetricians and Gynecologists (ACOG) 2002 classification. The ACOG Task Force Report on Hypertension in Pregnancy (2013) and The international Society for the Study of Hypertension in Pregnancy (ISSHP) (2014) have published new classifications, which change the paradigm that the diagnosis of preeclampsia always requires proteinuria. Here we studied how the new classifications would affect the pre-eclampsia diagnoses in the FINNPEC cohort. Methods We re-evaluated pre-eclampsia diagnosis using the ACOG 2013 and the ISSHP 2014 classifications in those pre-eclamptic women with the amount of proteinuria not exceeding 1+ in dipstick (N=68) and in women with gestational hypertension (N=138). Results Number of women with pre-eclampsia increased 0.5% (1454/1447) according to the ACOG 2013 criteria and decreased 0.9% (1434/1447) according to the ISSHP 2014 criteria. All 68 women with the amount of proteinuria not exceeding 1+ in dipstick diagnosed originally pre-eclamptic met the ACOG 2013 criteria but only 20 women (29.4%) met the ISSHP 2014 criteria. Seven (5.1%) and 35 (25.4%) women with gestational hypertension were diagnosed with pre-eclampsia according to the ACOG 2013 and the ISSHP 2014 criteria, respectively. Conclusions Only minor changes were observed in the total number of pre-eclamptic women in the FINNPEC cohort when comparing the modified ACOC 2002 classification with the ACOG 2013 and ISSHP 2014 classifications.
Published: 2016

16. FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

Author: Livingstone, Katherine M, Celis-Morales, Carlos, Papandonatos, George D, Erar, Bahar, Florez, Jose C, Jablonski, Kathleen A, Razquin, Cristina, Marti, Amelia, Heianza, Yoriko, Huang, Tao, Sacks, Frank M, Svendstrup, Mathilde, Sui, Xuemei, Church, Timothy S, Jääskeläinen, Tiina, Lindström, Jaana, Tuomilehto, Jaako, Uusitupa, Matti, Rankinen, Tuomo, Saris, Wim HM, Hansen, Torben, Pedersen, Oluf, Astrup, Arne, Sørensen, Thorkild IA, Qi, Lu, Bray, George A, Martinez-Gonzalez, Miguel A, Martinez, J Alfredo, Franks, Paul W, McCaffery, Jeanne M, Lara, Jose, Mathers, John C, Livingstone, Katherine M, Celis-Morales, Carlos, Papandonatos, George D, Erar, Bahar, Florez, Jose C, Jablonski, Kathleen A, Razquin, Cristina, Marti, Amelia, Heianza, Yoriko, Huang, Tao, Sacks, Frank M, Svendstrup, Mathilde, Sui, Xuemei, Church, Timothy S, Jääskeläinen, Tiina, Lindström, Jaana, Tuomilehto, Jaako, Uusitupa, Matti, Rankinen, Tuomo, Saris, Wim HM, Hansen, Torben, Pedersen, Oluf, Astrup, Arne, Sørensen, Thorkild IA, Qi, Lu, Bray, George A, Martinez-Gonzalez, Miguel A, Martinez, J Alfredo, Franks, Paul W, McCaffery, Jeanne M, Lara, Jose, and Mathers, John C
Abstract: OBJECTIVE: To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials. DESIGN: Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials. DATA SOURCES: Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015. ELIGIBILITY CRITERIA FOR STUDY SELECTION: Randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions. Gene by treatment interaction models were fitted to individual participant data from all studies included in this review, using allele dose coding for genetic effects and a common set of covariates. Study level interactions were combined using random effect models. Metaregression and subgroup analysis were used to assess sources of study heterogeneity. RESULTS: We identified eight eligible randomised controlled trials for the systematic review and meta-analysis (n=9563). Overall, differential changes in body mass index, body weight, and waist circumference in response to weight loss intervention were not significantly different between FTO genotypes. Sensitivity analyses indicated that differential changes in body mass index, body weight, and waist circumference by FTO genotype did not differ by intervention type, intervention length, ethnicity, sample size, sex, and baseline body mass index and age category. CONCLUSIONS: We have observed that carriage of the FTO minor allele was not associated with differential change in adiposity after weight loss interventions. These findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus gen
Published: 2016

17. FTO genotype and weight loss:systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

Author: Livingstone, Katherine M, Celis-Morales, Carlos, Papandonatos, George D, Erar, Bahar, Florez, Jose C, Jablonski, Kathleen A, Razquin, Cristina, Marti, Amelia, Heianza, Yoriko, Huang, Tao, Sacks, Frank M, Svendstrup, Mathilde, Sui, Xuemei, Church, Timothy S, Jääskeläinen, Tiina, Lindström, Jaana, Tuomilehto, Jaakko, Uusitupa, Matti, Rankinen, Tuomo, Saris, Wim H M, Hansen, Torben, Pedersen, Oluf, Astrup, Arne, Sørensen, Thorkild I.A., Lu, Qi, Bray, George A., Martinez-Gonzalez, Miguel A, Martinez, J Alfredo, Franks, Paul W, McCaffery, Jeanne M, Lara, Jose, Mathers, John C., Livingstone, Katherine M, Celis-Morales, Carlos, Papandonatos, George D, Erar, Bahar, Florez, Jose C, Jablonski, Kathleen A, Razquin, Cristina, Marti, Amelia, Heianza, Yoriko, Huang, Tao, Sacks, Frank M, Svendstrup, Mathilde, Sui, Xuemei, Church, Timothy S, Jääskeläinen, Tiina, Lindström, Jaana, Tuomilehto, Jaakko, Uusitupa, Matti, Rankinen, Tuomo, Saris, Wim H M, Hansen, Torben, Pedersen, Oluf, Astrup, Arne, Sørensen, Thorkild I.A., Lu, Qi, Bray, George A., Martinez-Gonzalez, Miguel A, Martinez, J Alfredo, Franks, Paul W, McCaffery, Jeanne M, Lara, Jose, and Mathers, John C.
Abstract: OBJECTIVE: To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials.DESIGN: Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials.DATA SOURCES: Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015.ELIGIBILITY CRITERIA FOR STUDY SELECTION: Randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions. Gene by treatment interaction models were fitted to individual participant data from all studies included in this review, using allele dose coding for genetic effects and a common set of covariates. Study level interactions were combined using random effect models. Metaregression and subgroup analysis were used to assess sources of study heterogeneity.RESULTS: We identified eight eligible randomised controlled trials for the systematic review and meta-analysis (n=9563). Overall, differential changes in body mass index, body weight, and waist circumference in response to weight loss intervention were not significantly different between FTO genotypes. Sensitivity analyses indicated that differential changes in body mass index, body weight, and waist circumference by FTO genotype did not differ by intervention type, intervention length, ethnicity, sample size, sex, and baseline body mass index and age category.CONCLUSIONS: We have observed that carriage of the FTO minor allele was not associated with differential change in adiposity after weight loss interventions. These findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor al
Published: 2016

18. FTO genotype and weight loss:systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

Author: Livingstone, Katherine M, Celis-Morales, Carlos, Papandonatos, George D, Erar, Bahar, Florez, Jose C, Jablonski, Kathleen A, Razquin, Cristina, Marti, Amelia, Heianza, Yoriko, Huang, Tao, Sacks, Frank M, Svendstrup, Mathilde, Sui, Xuemei, Church, Timothy S, Jääskeläinen, Tiina, Lindström, Jaana, Tuomilehto, Jaakko, Uusitupa, Matti, Rankinen, Tuomo, Saris, Wim H M, Hansen, Torben, Pedersen, Oluf, Astrup, Arne, Sørensen, Thorkild I.A., Lu, Qi, Bray, George A., Martinez-Gonzalez, Miguel A, Martinez, J Alfredo, Franks, Paul W, McCaffery, Jeanne M, Lara, Jose, Mathers, John C., Livingstone, Katherine M, Celis-Morales, Carlos, Papandonatos, George D, Erar, Bahar, Florez, Jose C, Jablonski, Kathleen A, Razquin, Cristina, Marti, Amelia, Heianza, Yoriko, Huang, Tao, Sacks, Frank M, Svendstrup, Mathilde, Sui, Xuemei, Church, Timothy S, Jääskeläinen, Tiina, Lindström, Jaana, Tuomilehto, Jaakko, Uusitupa, Matti, Rankinen, Tuomo, Saris, Wim H M, Hansen, Torben, Pedersen, Oluf, Astrup, Arne, Sørensen, Thorkild I.A., Lu, Qi, Bray, George A., Martinez-Gonzalez, Miguel A, Martinez, J Alfredo, Franks, Paul W, McCaffery, Jeanne M, Lara, Jose, and Mathers, John C.
Abstract: OBJECTIVE: To assess the effect of the FTO genotype on weight loss after dietary, physical activity, or drug based interventions in randomised controlled trials.DESIGN: Systematic review and random effects meta-analysis of individual participant data from randomised controlled trials.DATA SOURCES: Ovid Medline, Scopus, Embase, and Cochrane from inception to November 2015.ELIGIBILITY CRITERIA FOR STUDY SELECTION: Randomised controlled trials in overweight or obese adults reporting reduction in body mass index, body weight, or waist circumference by FTO genotype (rs9939609 or a proxy) after dietary, physical activity, or drug based interventions. Gene by treatment interaction models were fitted to individual participant data from all studies included in this review, using allele dose coding for genetic effects and a common set of covariates. Study level interactions were combined using random effect models. Metaregression and subgroup analysis were used to assess sources of study heterogeneity.RESULTS: We identified eight eligible randomised controlled trials for the systematic review and meta-analysis (n=9563). Overall, differential changes in body mass index, body weight, and waist circumference in response to weight loss intervention were not significantly different between FTO genotypes. Sensitivity analyses indicated that differential changes in body mass index, body weight, and waist circumference by FTO genotype did not differ by intervention type, intervention length, ethnicity, sample size, sex, and baseline body mass index and age category.CONCLUSIONS: We have observed that carriage of the FTO minor allele was not associated with differential change in adiposity after weight loss interventions. These findings show that individuals carrying the minor allele respond equally well to dietary, physical activity, or drug based weight loss interventions and thus genetic predisposition to obesity associated with the FTO minor al
Published: 2016

19. FTO genetic variants, dietary intake and body mass index : insights from 177 330 individuals

Author: Qi, Qibin, Kilpeläinen, Tuomas O, Downer, Mary K, Tanaka, Toshiko, Smith, Caren E, Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y, Renström, Frida, Lin, Xiaochen, Angquist, Lars H, Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarunveer Singh, Boer, Jolanda M A, Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H M, Holloway, John W, Houston, Denise K, Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A, Jääskeläinen, Tiina, Lee, Nanette R, Lehtimäki, Terho, Lemaitre, Rozenn N, Lu, Wei, Luben, Robert N, Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L, Ngwa, Julius S, Perusse, Louis, van Rooij, Frank J A, Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K, Zhu, Jingwen, Borecki, Ingrid B, Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V, Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G, Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K, Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T, Uitterlinden, André G, Carola Zillikens, M, Franco, Oscar H, Shyong Tai, E, Ou Shu, Xiao, Siscovick, David S, Toft, Ulla, Monique Verschuren, W M, Vollenweider, Peter, Wareham, Nicholas J, Witteman, Jacqueline C M, Zheng, Wei, Ridker, Paul M, Kang, Jae H, Liang, Liming, Jensen, Majken K, Curhan, Gary C, Pasquale, Louis R, Hunter, David J, Mohlke, Karen L, Uusitupa, Matti, Adrienne Cupples, L, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I, Franks, Paul, Sørensen, Thorkild I A, Hu, Frank B, Loos, Ruth J F, Nettleton, Jennifer A, Qi, Lu, Qi, Qibin, Kilpeläinen, Tuomas O, Downer, Mary K, Tanaka, Toshiko, Smith, Caren E, Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y, Renström, Frida, Lin, Xiaochen, Angquist, Lars H, Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarunveer Singh, Boer, Jolanda M A, Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H M, Holloway, John W, Houston, Denise K, Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A, Jääskeläinen, Tiina, Lee, Nanette R, Lehtimäki, Terho, Lemaitre, Rozenn N, Lu, Wei, Luben, Robert N, Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L, Ngwa, Julius S, Perusse, Louis, van Rooij, Frank J A, Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K, Zhu, Jingwen, Borecki, Ingrid B, Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V, Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G, Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K, Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T, Uitterlinden, André G, Carola Zillikens, M, Franco, Oscar H, Shyong Tai, E, Ou Shu, Xiao, Siscovick, David S, Toft, Ulla, Monique Verschuren, W M, Vollenweider, Peter, Wareham, Nicholas J, Witteman, Jacqueline C M, Zheng, Wei, Ridker, Paul M, Kang, Jae H, Liang, Liming, Jensen, Majken K, Curhan, Gary C, Pasquale, Louis R, Hunter, David J, Mohlke, Karen L, Uusitupa, Matti, Adrienne Cupples, L, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I, Franks, Paul, Sørensen, Thorkild I A, Hu, Frank B, Loos, Ruth J F, Nettleton, Jennifer A, and Qi, Lu
Abstract: FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.
Published: 2014
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20. Effects of Whole Grain, Fish and Bilberries on Serum Metabolic Profile and Lipid Transfer Protein Activities: A Randomized Trial (Sysdimet)

Author: University of Helsinki, Medicum, University of Helsinki, Department of Medicine, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Lankinen, Maria, Kolehmainen, Marjukka, Jääskeläinen, Tiina, Paananen, Jussi, Joukamo, Laura, Kangas, Antti J., Soininen, Pasi, Poutanen, Kaisa, Mykkanen, Hannu, Gylling, Helena, Oresic, Matej, Jauhiainen, Matti, Ala-Korpela, Mika, Uusitupa, Matti, Schwab, Ursula, University of Helsinki, Medicum, University of Helsinki, Department of Medicine, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), Lankinen, Maria, Kolehmainen, Marjukka, Jääskeläinen, Tiina, Paananen, Jussi, Joukamo, Laura, Kangas, Antti J., Soininen, Pasi, Poutanen, Kaisa, Mykkanen, Hannu, Gylling, Helena, Oresic, Matej, Jauhiainen, Matti, Ala-Korpela, Mika, Uusitupa, Matti, and Schwab, Ursula
Published: 2014

21. Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities : a randomized trial (Sysdimet)

Author: Lankinen, Maria, Kolehmainen, Marjukka, Jääskeläinen, Tiina, Paananen, Jussi, Joukamo, Laura, Kangas, Antti J., Soininen, Pasi, Poutanen, Kaisa, Mykkänen, Hannu, Gylling, Helena, Oresic, Matej, Jauhiainen, Matti, Ala-Korpela, Mika, Uusitupa, Matti, Schwab, Ursula, Lankinen, Maria, Kolehmainen, Marjukka, Jääskeläinen, Tiina, Paananen, Jussi, Joukamo, Laura, Kangas, Antti J., Soininen, Pasi, Poutanen, Kaisa, Mykkänen, Hannu, Gylling, Helena, Oresic, Matej, Jauhiainen, Matti, Ala-Korpela, Mika, Uusitupa, Matti, and Schwab, Ursula
Abstract: OBJECTIVE: We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome. METHODS: Altogether 131 subjects (40-70 y, BMI 26-39 kg/m(2)) with impaired glucose metabolism and features of the metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as low-molecular-weight metabolites. RESULTS: There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable. CONCLUSIONS: The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly exp, Funding agencies:Academy of Finland 117844 118590 117996 131460 137870 257545European Commission FOOD-CT-2005-514008Kuopio University Hospital 5106 5168 5254Sigrid Juselius FoundationTEKES - the Finnish Funding Agency for Technology and InnovationUniversity of OuluFinnish Diabetes Research FoundationNordic Centre of Excellence on Systems Biology in Controlled Dietary Intervention and Cohort Studies (SYSDIET) 070014Fazer bakeries OyVaasan Vaasan OyKE Leipa OyLeipomo RuistahkaLeipomo KoskelonseutuRaisio OyjPakkasmarja OyJoswola Oy
Published: 2014
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22. FTO genetic variants, dietary intake and body mass index:insights from 177 330 individuals

Author: Qi, Qibin, Oskari Kilpeläinen, Tuomas, Downer, Mary K, Tanaka, Toshiko, Smith, Caren E, Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y, Renström, Frida, Lin, Xiaochen, Angquist, Lars H, Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarun Veer Singh, Boer, Jolanda M A, Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H M, Holloway, John W, Houston, Denise K, Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A, Jääskeläinen, Tiina, Lee, Nanette R, Lehtimäki, Terho, Lemaitre, Rozenn N, Lu, Wei, Luben, Robert N, Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L, Ngwa, Julius S, Perusse, Louis, van Rooij, Frank J A, Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K, Zhu, Jingwen, Borecki, Ingrid B, Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V, Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G, Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K, Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T, Uitterlinden, André G, Carola Zillikens, M, Franco, Oscar H, Shyong Tai, E, Ou Shu, Xiao, Siscovick, David S, Toft, Ulla, Monique Verschuren, W M, Vollenweider, Peter, Wareham, Nicholas J, Witteman, Jacqueline C M, Zheng, Wei, Ridker, Paul M, Kang, Jae H, Liang, Liming, Jensen, Majken K, Curhan, Gary C, Pasquale, Louis R, Hunter, David J, Mohlke, Karen L, Uusitupa, Matti, Adrienne Cupples, L, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I, Franks, Paul W, Sørensen, Thorkild I A, Hu, Frank B, Loos, Ruth J F, Nettleton, Jennifer A, Qi, Lu, Qi, Qibin, Oskari Kilpeläinen, Tuomas, Downer, Mary K, Tanaka, Toshiko, Smith, Caren E, Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y, Renström, Frida, Lin, Xiaochen, Angquist, Lars H, Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarun Veer Singh, Boer, Jolanda M A, Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H M, Holloway, John W, Houston, Denise K, Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A, Jääskeläinen, Tiina, Lee, Nanette R, Lehtimäki, Terho, Lemaitre, Rozenn N, Lu, Wei, Luben, Robert N, Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L, Ngwa, Julius S, Perusse, Louis, van Rooij, Frank J A, Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K, Zhu, Jingwen, Borecki, Ingrid B, Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V, Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G, Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K, Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T, Uitterlinden, André G, Carola Zillikens, M, Franco, Oscar H, Shyong Tai, E, Ou Shu, Xiao, Siscovick, David S, Toft, Ulla, Monique Verschuren, W M, Vollenweider, Peter, Wareham, Nicholas J, Witteman, Jacqueline C M, Zheng, Wei, Ridker, Paul M, Kang, Jae H, Liang, Liming, Jensen, Majken K, Curhan, Gary C, Pasquale, Louis R, Hunter, David J, Mohlke, Karen L, Uusitupa, Matti, Adrienne Cupples, L, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I, Franks, Paul W, Sørensen, Thorkild I A, Hu, Frank B, Loos, Ruth J F, Nettleton, Jennifer A, and Qi, Lu
Abstract: FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.
Published: 2014

23. FTO genetic variants, dietary intake and body mass index:insights from 177 330 individuals

Author: Qi, Qibin, Oskari Kilpeläinen, Tuomas, Downer, Mary K, Tanaka, Toshiko, Smith, Caren E, Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y, Renström, Frida, Lin, Xiaochen, Angquist, Lars H, Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarun Veer Singh, Boer, Jolanda M A, Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H M, Holloway, John W, Houston, Denise K, Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A, Jääskeläinen, Tiina, Lee, Nanette R, Lehtimäki, Terho, Lemaitre, Rozenn N, Lu, Wei, Luben, Robert N, Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L, Ngwa, Julius S, Perusse, Louis, van Rooij, Frank J A, Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K, Zhu, Jingwen, Borecki, Ingrid B, Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V, Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G, Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K, Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T, Uitterlinden, André G, Carola Zillikens, M, Franco, Oscar H, Shyong Tai, E, Ou Shu, Xiao, Siscovick, David S, Toft, Ulla, Monique Verschuren, W M, Vollenweider, Peter, Wareham, Nicholas J, Witteman, Jacqueline C M, Zheng, Wei, Ridker, Paul M, Kang, Jae H, Liang, Liming, Jensen, Majken K, Curhan, Gary C, Pasquale, Louis R, Hunter, David J, Mohlke, Karen L, Uusitupa, Matti, Adrienne Cupples, L, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I, Franks, Paul W, Sørensen, Thorkild I A, Hu, Frank B, Loos, Ruth J F, Nettleton, Jennifer A, Qi, Lu, Qi, Qibin, Oskari Kilpeläinen, Tuomas, Downer, Mary K, Tanaka, Toshiko, Smith, Caren E, Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y, Renström, Frida, Lin, Xiaochen, Angquist, Lars H, Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarun Veer Singh, Boer, Jolanda M A, Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H M, Holloway, John W, Houston, Denise K, Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A, Jääskeläinen, Tiina, Lee, Nanette R, Lehtimäki, Terho, Lemaitre, Rozenn N, Lu, Wei, Luben, Robert N, Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L, Ngwa, Julius S, Perusse, Louis, van Rooij, Frank J A, Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K, Zhu, Jingwen, Borecki, Ingrid B, Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V, Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G, Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K, Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T, Uitterlinden, André G, Carola Zillikens, M, Franco, Oscar H, Shyong Tai, E, Ou Shu, Xiao, Siscovick, David S, Toft, Ulla, Monique Verschuren, W M, Vollenweider, Peter, Wareham, Nicholas J, Witteman, Jacqueline C M, Zheng, Wei, Ridker, Paul M, Kang, Jae H, Liang, Liming, Jensen, Majken K, Curhan, Gary C, Pasquale, Louis R, Hunter, David J, Mohlke, Karen L, Uusitupa, Matti, Adrienne Cupples, L, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I, Franks, Paul W, Sørensen, Thorkild I A, Hu, Frank B, Loos, Ruth J F, Nettleton, Jennifer A, and Qi, Lu
Abstract: FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m(2), P = 1.9 × 10(-105)), and all participants (0.30 [0.30, 0.35] kg/m(2), P = 3.6 × 10(-107)). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10(-16)), and relative weak associations with lower total energy intake (-6.4 [-10.1, -2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (-0.07 [-0.11, -0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10(-9)) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity.
Published: 2014

24. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

Author: Qi, Qibin, Kilpeläinen, Tuomas O., Downer, Mary K., Tanaka, Toshiko, Smith, Caren E., Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y., Renström, Frida, Lin, Xiaochen, Ängquist, Lars H., Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarunveer Singh, Boer, Jolanda M.A., Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H.M., Holloway, John W., Houston, Denise K., Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A., Jääskeläinen, Tiina, Lee, Nanette R., Lehtimäki, Terho, Lemaitre, Rozenn N., Lu, Wei, Luben, Robert N., Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L., Ngwa, Julius S., Perusse, Louis, van Rooij, Frank J.A., Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K., Zhu, Jingwen, Borecki, Ingrid B., Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V., Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G., Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K., Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T., Uitterlinden, André G., Zillikens, M. Carola, Franco, Oscar H., Shyong Tai, E., Ou Shu, Xiao, Siscovick, David S., Toft, Ulla, Verschuren, W.M. Monique, Vollenweider, Peter, Wareham, Nicholas J., Witteman, Jacqueline C.M., Zheng, Wei, Ridker, Paul M., Kang, Jae H., Liang, Liming, Jensen, Majken K., Curhan, Gary C., Pasquale, Louis R., Hunter, David J., Mohlke, Karen L., Uusitupa, Matti, Cupples, L. Adrienne, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I., Franks, Paul W., Sørensen, Thorkild I.A., Hu, Frank B., Loos, Ruth J. F., Nettleton, Jennifer A., Qi, Lu, Qi, Qibin, Kilpeläinen, Tuomas O., Downer, Mary K., Tanaka, Toshiko, Smith, Caren E., Sluijs, Ivonne, Sonestedt, Emily, Chu, Audrey Y., Renström, Frida, Lin, Xiaochen, Ängquist, Lars H., Huang, Jinyan, Liu, Zhonghua, Li, Yanping, Asif Ali, Muhammad, Xu, Min, Ahluwalia, Tarunveer Singh, Boer, Jolanda M.A., Chen, Peng, Daimon, Makoto, Eriksson, Johan, Perola, Markus, Friedlander, Yechiel, Gao, Yu-Tang, Heppe, Denise H.M., Holloway, John W., Houston, Denise K., Kanoni, Stavroula, Kim, Yu-Mi, Laaksonen, Maarit A., Jääskeläinen, Tiina, Lee, Nanette R., Lehtimäki, Terho, Lemaitre, Rozenn N., Lu, Wei, Luben, Robert N., Manichaikul, Ani, Männistö, Satu, Marques-Vidal, Pedro, Monda, Keri L., Ngwa, Julius S., Perusse, Louis, van Rooij, Frank J.A., Xiang, Yong-Bing, Wen, Wanqing, Wojczynski, Mary K., Zhu, Jingwen, Borecki, Ingrid B., Bouchard, Claude, Cai, Qiuyin, Cooper, Cyrus, Dedoussis, George V., Deloukas, Panos, Ferrucci, Luigi, Forouhi, Nita G., Hansen, Torben, Christiansen, Lene, Hofman, Albert, Johansson, Ingegerd, Jørgensen, Torben, Karasawa, Shigeru, Khaw, Kay-Tee, Kim, Mi-Kyung, Kristiansson, Kati, Li, Huaixing, Lin, Xu, Liu, Yongmei, Lohman, Kurt K., Long, Jirong, Mikkilä, Vera, Mozaffarian, Dariush, North, Kari, Pedersen, Oluf, Raitakari, Olli, Rissanen, Harri, Tuomilehto, Jaakko, van der Schouw, Yvonne T., Uitterlinden, André G., Zillikens, M. Carola, Franco, Oscar H., Shyong Tai, E., Ou Shu, Xiao, Siscovick, David S., Toft, Ulla, Verschuren, W.M. Monique, Vollenweider, Peter, Wareham, Nicholas J., Witteman, Jacqueline C.M., Zheng, Wei, Ridker, Paul M., Kang, Jae H., Liang, Liming, Jensen, Majken K., Curhan, Gary C., Pasquale, Louis R., Hunter, David J., Mohlke, Karen L., Uusitupa, Matti, Cupples, L. Adrienne, Rankinen, Tuomo, Orho-Melander, Marju, Wang, Tao, Chasman, Daniel I., Franks, Paul W., Sørensen, Thorkild I.A., Hu, Frank B., Loos, Ruth J. F., Nettleton, Jennifer A., and Qi, Lu
Abstract: FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) is complex and results from previous often small-scale studies in humans are highly inconsistent. We performed large-scale analyses based on data from 177 330 adults (154 439 Whites, 5776 African Americans and 17 115 Asians) from 40 studies to examine: (i) the association between the FTO-rs9939609 variant (or a proxy single-nucleotide polymorphism) and total energy and macronutrient intake and (ii) the interaction between the FTO variant and dietary intake on BMI. The minor allele (A-allele) of the FTO-rs9939609 variant was associated with higher BMI in Whites (effect per allele = 0.34 [0.31, 0.37] kg/m2, P = 1.9 × 10−105), and all participants (0.30 [0.30, 0.35] kg/m2, P = 3.6 × 10−107). The BMI-increasing allele of the FTO variant showed a significant association with higher dietary protein intake (effect per allele = 0.08 [0.06, 0.10] %, P = 2.4 × 10−16), and relative weak associations with lower total energy intake (−6.4 [−10.1, −2.6] kcal/day, P = 0.001) and lower dietary carbohydrate intake (−0.07 [−0.11, −0.02] %, P = 0.004). The associations with protein (P = 7.5 × 10−9) and total energy (P = 0.002) were attenuated but remained significant after adjustment for BMI. We did not find significant interactions between the FTO variant and dietary intake of total energy, protein, carbohydrate or fat on BMI. Our findings suggest a positive association between the BMI-increasing allele of FTO variant and higher dietary protein intake and offer insight into potential link between FTO, dietary protein intake and adiposity

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1. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

2. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

3. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

4. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

5. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

6. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

7. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

8. Genetic predisposition to hypertension is associated with preeclampsia in European and Central Asian women

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13. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

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15. The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort

16. FTO genotype and weight loss: systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

17. FTO genotype and weight loss:systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

18. FTO genotype and weight loss:systematic review and meta-analysis of 9563 individual participant data from eight randomised controlled trials

19. FTO genetic variants, dietary intake and body mass index : insights from 177 330 individuals

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22. FTO genetic variants, dietary intake and body mass index:insights from 177 330 individuals

23. FTO genetic variants, dietary intake and body mass index:insights from 177 330 individuals

24. FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

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