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1. Simulation-aided occupant-centric building design: A critical review of tools, methods, and applications

Author

Azar, E, Azar, E, O'Brien, W, Carlucci, S, Hong, T, Sonta, A, Kim, J, Andargie, MS, Abuimara, T, El Asmar, M, Jain, RK, Ouf, MM, Tahmasebi, F, Zhou, J, Azar, E, Azar, E, O'Brien, W, Carlucci, S, Hong, T, Sonta, A, Kim, J, Andargie, MS, Abuimara, T, El Asmar, M, Jain, RK, Ouf, MM, Tahmasebi, F, and Zhou, J

Abstract

Occupants are active participants in their built environment, affecting its performance while simultaneously being affected by its design and indoor environmental conditions. With recent advances in computer modeling, simulation tools, and analysis techniques, topics such as human-building interactions and occupant behavior have gained significant interest in the literature given their premise of improving building design processes and operating strategies. In practice, the focus of occupant-centric literature has been mostly geared towards the latter (i.e., operation), leaving the implications on building design practices underexplored. This paper fills the gap by providing a critical review of existing studies applying computer-based modeling and simulation to guide occupant-centric building design. The reviewed papers are organized along four main themes, namely occupant-centric: (i) metrics of building performance, (ii) modeling and simulation approaches, (iii) design methods and applications, and (iv) supporting practices and mechanisms. Important barriers are identified for a more effective application of occupant-centric building design practices, including the limited consideration of metrics beyond energy efficiency (e.g., occupant well-being and space planning), the limited implementation and validation of the proposed methods, and the lack of integration of occupant behavior modeling in existing building performance simulation tools. Future research directions are discussed, covering large-scale international data collection efforts to move from generic assumptions about occupant behavior to specific/localized knowledge, improved metrics of measuring building performance, and improved industry practices, such as building codes, to promote an occupant-in-the-loop approach to the building design process.

Published
2020

2. Simulation-aided occupant-centric building design: A critical review of tools, methods, and applications

Author

Azar, E, Azar, E, O'Brien, W, Carlucci, S, Hong, T, Sonta, A, Kim, J, Andargie, MS, Abuimara, T, El Asmar, M, Jain, RK, Ouf, MM, Tahmasebi, F, Zhou, J, Azar, E, Azar, E, O'Brien, W, Carlucci, S, Hong, T, Sonta, A, Kim, J, Andargie, MS, Abuimara, T, El Asmar, M, Jain, RK, Ouf, MM, Tahmasebi, F, and Zhou, J

Abstract

Occupants are active participants in their built environment, affecting its performance while simultaneously being affected by its design and indoor environmental conditions. With recent advances in computer modeling, simulation tools, and analysis techniques, topics such as human-building interactions and occupant behavior have gained significant interest in the literature given their premise of improving building design processes and operating strategies. In practice, the focus of occupant-centric literature has been mostly geared towards the latter (i.e., operation), leaving the implications on building design practices underexplored. This paper fills the gap by providing a critical review of existing studies applying computer-based modeling and simulation to guide occupant-centric building design. The reviewed papers are organized along four main themes, namely occupant-centric: (i) metrics of building performance, (ii) modeling and simulation approaches, (iii) design methods and applications, and (iv) supporting practices and mechanisms. Important barriers are identified for a more effective application of occupant-centric building design practices, including the limited consideration of metrics beyond energy efficiency (e.g., occupant well-being and space planning), the limited implementation and validation of the proposed methods, and the lack of integration of occupant behavior modeling in existing building performance simulation tools. Future research directions are discussed, covering large-scale international data collection efforts to move from generic assumptions about occupant behavior to specific/localized knowledge, improved metrics of measuring building performance, and improved industry practices, such as building codes, to promote an occupant-in-the-loop approach to the building design process.

Published
2020

3. Taxonomy of the order Bunyavirales: second update 2018

Author

Maes, P, Adkins, S, Alkhovsky, S, Avsic-Zupanc, T, Ballinger, M, Bente, D, Beer, M, Bergeron, E, Blair, C, Briese, T, Buchmeier, M, Burt, F, Calisher, C, Charrel, R, Choi, I, Clegg, J, de la Torre, J, de Lamballerie, X, Derisi, J, Digiaro, M, Drebot, M, Ebihara, H, Elbeaino, T, Ergunay, K, Fulhorst, C, Garrison, A, Gao, G, Gonzalez, J, Groschup, M, Gunther, S, Haenni, A, Hall, R, Hewson, R, Hughes, H, Jain, R, Jonson, M, Junglen, S, Klempa, B, Klingstrom, J, Kormelink, R, Lambert, A, Langevin, S, Lukashevich, I, Marklewitz, M, Martelli, G, Mielke-Ehret, N, Mirazimi, A, Muhlbach, H, Naidu, R, Nunes, M, Palacios, G, Papa, A, Paweska, J, Peters, C, Plyusnin, A, Radoshitzky, S, Resende, R, Romanowski, V, Sall, A, Salvato, M, Sasaya, T, Schmaljohn, C, Shi, X, Shirako, Y, Simmonds, P, Sironi, M, Song, J, Spengler, J, Stenglein, M, Tesh, R, Turina, M, Wei, T, Whitfield, A, Yeh, S, Zerbini, F, Zhang, Y, Zhou, X, Kuhn, J, Maes P, Adkins S, Alkhovsky SV, Avsic-Zupanc T, Ballinger MJ, Bente DA, Beer M, Bergeron E, Blair CD, Briese T, Buchmeier MJ, Burt FJ, Calisher CH, Charrel RN, Choi IR, Clegg JCS, de la Torre JC, de Lamballerie X, DeRisi JL, Digiaro M, Drebot M, Ebihara H, Elbeaino T, Ergunay K, Fulhorst CF, Garrison AR, Gao GF, Gonzalez JPJ, Groschup MH, Gunther S, Haenni AL, Hall RA, Hewson R, Hughes HR, Jain RK, Jonson MG, Junglen S, Klempa B, Klingstrom J, Kormelink R, Lambert AJ, Langevin SA, Lukashevich IS, Marklewitz M, Martelli GP, Mielke-Ehret N, Mirazimi A, Muhlbach HP, Naidu R, Nunes MRT, Palacios G, Papa A, Paweska JT, Peters CJ, Plyusnin A, Radoshitzky SR, Resende RO, Romanowski V, Sall AA, Salvato MS, Sasaya T, Schmaljohn C, Shi XH, Shirako Y, Simmonds P, Sironi M, Song JW, Spengler JR, Stenglein MD, Tesh RB, Turina M, Wei TY, Whitfield AE, Yeh SD, Zerbini FM, Zhang YZ, Zhou XP, Kuhn JH, Maes, P, Adkins, S, Alkhovsky, S, Avsic-Zupanc, T, Ballinger, M, Bente, D, Beer, M, Bergeron, E, Blair, C, Briese, T, Buchmeier, M, Burt, F, Calisher, C, Charrel, R, Choi, I, Clegg, J, de la Torre, J, de Lamballerie, X, Derisi, J, Digiaro, M, Drebot, M, Ebihara, H, Elbeaino, T, Ergunay, K, Fulhorst, C, Garrison, A, Gao, G, Gonzalez, J, Groschup, M, Gunther, S, Haenni, A, Hall, R, Hewson, R, Hughes, H, Jain, R, Jonson, M, Junglen, S, Klempa, B, Klingstrom, J, Kormelink, R, Lambert, A, Langevin, S, Lukashevich, I, Marklewitz, M, Martelli, G, Mielke-Ehret, N, Mirazimi, A, Muhlbach, H, Naidu, R, Nunes, M, Palacios, G, Papa, A, Paweska, J, Peters, C, Plyusnin, A, Radoshitzky, S, Resende, R, Romanowski, V, Sall, A, Salvato, M, Sasaya, T, Schmaljohn, C, Shi, X, Shirako, Y, Simmonds, P, Sironi, M, Song, J, Spengler, J, Stenglein, M, Tesh, R, Turina, M, Wei, T, Whitfield, A, Yeh, S, Zerbini, F, Zhang, Y, Zhou, X, Kuhn, J, Maes P, Adkins S, Alkhovsky SV, Avsic-Zupanc T, Ballinger MJ, Bente DA, Beer M, Bergeron E, Blair CD, Briese T, Buchmeier MJ, Burt FJ, Calisher CH, Charrel RN, Choi IR, Clegg JCS, de la Torre JC, de Lamballerie X, DeRisi JL, Digiaro M, Drebot M, Ebihara H, Elbeaino T, Ergunay K, Fulhorst CF, Garrison AR, Gao GF, Gonzalez JPJ, Groschup MH, Gunther S, Haenni AL, Hall RA, Hewson R, Hughes HR, Jain RK, Jonson MG, Junglen S, Klempa B, Klingstrom J, Kormelink R, Lambert AJ, Langevin SA, Lukashevich IS, Marklewitz M, Martelli GP, Mielke-Ehret N, Mirazimi A, Muhlbach HP, Naidu R, Nunes MRT, Palacios G, Papa A, Paweska JT, Peters CJ, Plyusnin A, Radoshitzky SR, Resende RO, Romanowski V, Sall AA, Salvato MS, Sasaya T, Schmaljohn C, Shi XH, Shirako Y, Simmonds P, Sironi M, Song JW, Spengler JR, Stenglein MD, Tesh RB, Turina M, Wei TY, Whitfield AE, Yeh SD, Zerbini FM, Zhang YZ, Zhou XP, and Kuhn JH

Abstract

In October 2018, the order Bunyavirales was amended by inclusion of the family Arenaviridae, abolishment of three families, creation of three new families, 19 new genera, and 14 new species, and renaming of three genera and 22 species. This article presents the updated taxonomy of the order Bunyavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV).

Published
2019

4. Consensus guidelines for the use and interpretation of angiogenesis assays

Author

Nowak-Sliwinska, P, Alitalo, K, Allen, E, Anisimov, A, Aplin, AC, Auerbach, R, Augustin, HG, Bates, DO, van Beijnum, JR, Bender, RHF, Bergers, G, Bikfalvi, A, Bischoff, J, Boeck, BC, Brooks, PC, Bussolino, F, Cakir, B, Carmeliet, P, Castranova, D, Cimpean, AM, Cleaver, O, Coukos, G, Davis, GE, De Palma, M, Dimberg, A, Dings, RPM, Djonov, V, Dudley, AC, Dufton, NP, Fendt, S-M, Ferrara, N, Fruttiger, M, Fukumura, D, Ghesquiere, B, Gong, Y, Griffin, RJ, Harris, AL, Hughes, CCW, Hultgren, NW, Iruela-Arispe, ML, Irving, M, Jain, RK, Kalluri, R, Kalucka, J, Kerbel, RS, Kitajewski, J, Klaassen, I, Kleinmann, HK, Koolwijk, P, Kuczynski, E, Kwak, BR, Marien, K, Melero-Martin, JM, Munn, LL, Nicosia, RF, Noel, A, Nurro, J, Olsson, A-K, Petrova, TV, Pietras, K, Pili, R, Pollard, JW, Post, MJ, Quax, PHA, Rabinovich, GA, Raica, M, Randi, AM, Ribatti, D, Ruegg, C, Schlingemann, RO, Schulte-Merker, S, Smith, LEH, Song, JW, Stacker, SA, Stalin, J, Stratman, AN, Van de Velde, M, van Hinsbergh, VWM, Vermeulen, PB, Waltenberger, J, Weinstein, BM, Xin, H, Yetkin-Arik, B, Yla-Herttuala, S, Yoder, MC, Griffioen, AW, Nowak-Sliwinska, P, Alitalo, K, Allen, E, Anisimov, A, Aplin, AC, Auerbach, R, Augustin, HG, Bates, DO, van Beijnum, JR, Bender, RHF, Bergers, G, Bikfalvi, A, Bischoff, J, Boeck, BC, Brooks, PC, Bussolino, F, Cakir, B, Carmeliet, P, Castranova, D, Cimpean, AM, Cleaver, O, Coukos, G, Davis, GE, De Palma, M, Dimberg, A, Dings, RPM, Djonov, V, Dudley, AC, Dufton, NP, Fendt, S-M, Ferrara, N, Fruttiger, M, Fukumura, D, Ghesquiere, B, Gong, Y, Griffin, RJ, Harris, AL, Hughes, CCW, Hultgren, NW, Iruela-Arispe, ML, Irving, M, Jain, RK, Kalluri, R, Kalucka, J, Kerbel, RS, Kitajewski, J, Klaassen, I, Kleinmann, HK, Koolwijk, P, Kuczynski, E, Kwak, BR, Marien, K, Melero-Martin, JM, Munn, LL, Nicosia, RF, Noel, A, Nurro, J, Olsson, A-K, Petrova, TV, Pietras, K, Pili, R, Pollard, JW, Post, MJ, Quax, PHA, Rabinovich, GA, Raica, M, Randi, AM, Ribatti, D, Ruegg, C, Schlingemann, RO, Schulte-Merker, S, Smith, LEH, Song, JW, Stacker, SA, Stalin, J, Stratman, AN, Van de Velde, M, van Hinsbergh, VWM, Vermeulen, PB, Waltenberger, J, Weinstein, BM, Xin, H, Yetkin-Arik, B, Yla-Herttuala, S, Yoder, MC, and Griffioen, AW

Abstract

The formation of new blood vessels, or angiogenesis, is a complex process that plays important roles in growth and development, tissue and organ regeneration, as well as numerous pathological conditions. Angiogenesis undergoes multiple discrete steps that can be individually evaluated and quantified by a large number of bioassays. These independent assessments hold advantages but also have limitations. This article describes in vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis and highlights critical aspects that are relevant for their execution and proper interpretation. As such, this collaborative work is the first edition of consensus guidelines on angiogenesis bioassays to serve for current and future reference.

Published
2018

7. Measurement of high energy neutrons by fission reactions

Author

Jain, RK, Prokofiev, AV, Smirnov, AN, Tommasino, L, Jain, RK, Prokofiev, AV, Smirnov, AN, and Tommasino, L

Abstract

In most high energy radiation fields, such as those encountered around accelerators or cosmic rays in the atmosphere, neutrons produce the largest percentage of the hadron dose. In these radiation fields, the neutron spectrum is typically formed by low en, Addresses: Jain RK, Natl Agcy Environm Protect, ANPA, I-00144 Rome, Italy. Natl Agcy Environm Protect, ANPA, I-00144 Rome, Italy. Univ Uppsala, Dept Neutron Res, S-75120 Uppsala, Sweden. VG Khlopin Radium Inst, St Petersburg 194021, Russia.

Published
2001

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