Search

Your search keyword '"Kapusta, Livia"' showing total 31 results
Start Over Author "Kapusta, Livia" Database OAIster
31 results on '"Kapusta, Livia"'

1. A Biomarker-Based Diagnostic Model for Cardiac Dysfunction in Childhood Cancer Survivors

Author

Speerpunt, Zorg en O&O, Cancer, Child Health, Leerink, Jan M., Feijen, Elizabeth A.M., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, van Dalen, Elvira C., van der Heiden-van der Loo, Margriet, Bresters, Dorine, Ronckers, Cécile M., de Vries, Andrica C.H., Neggers, Sebastian, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., Kok, Wouter E.M., Speerpunt, Zorg en O&O, Cancer, Child Health, Leerink, Jan M., Feijen, Elizabeth A.M., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, van Dalen, Elvira C., van der Heiden-van der Loo, Margriet, Bresters, Dorine, Ronckers, Cécile M., de Vries, Andrica C.H., Neggers, Sebastian, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., and Kok, Wouter E.M.

Published
2024

2. Treatments affecting splenic function as a risk factor for valvular heart disease in Childhood Cancer Survivors:A DCCSS-LATER study

Author

Houtman, Bente M., Walraven, Iris, Kapusta, Livia, Teske, Arco J., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., van den Heuvel-Eibrink, Marry M., Versluys, A. B. Birgitta, Bresters, Dorine, van der Heiden-vander Loo, Margriet, Ronckers, Cecile, Kok, Wouter E. M., van der Pal, Helena J. H., Pluijm, Saskia M. F., Janssens, Geert O., Blijlevens, Nicole M. A., Kremer, Leontien C. M., Loonen, Jacqueline J., Feijen, E. A. M. Lieke, Houtman, Bente M., Walraven, Iris, Kapusta, Livia, Teske, Arco J., van Dulmen-den Broeder, Eline, Tissing, Wim J. E., van den Heuvel-Eibrink, Marry M., Versluys, A. B. Birgitta, Bresters, Dorine, van der Heiden-vander Loo, Margriet, Ronckers, Cecile, Kok, Wouter E. M., van der Pal, Helena J. H., Pluijm, Saskia M. F., Janssens, Geert O., Blijlevens, Nicole M. A., Kremer, Leontien C. M., Loonen, Jacqueline J., and Feijen, E. A. M. Lieke

Abstract

PurposeSplenectomy might be a risk factor for valvular heart disease (VHD) in adult Hodgkin lymphoma survivors. As this risk is still unclear for childhood cancer survivors (CCS), the aim of this study is to evaluate the association between treatments affecting splenic function (splenectomy and radiotherapy involving the spleen) and VHD in CCS.MethodsCCS were enrolled from the DCCSS-LATER cohort, consisting of 6,165 five-year CCS diagnosed between 1963 and 2002. Symptomatic VHD, defined as symptoms combined with a diagnostic test indicating VHD, was assessed from questionnaires and validated using medical records. Differences in the cumulative incidence of VHD between CCS who received treatments affecting splenic function and CCS who did not were assessed using the Gray test. Risk factors were analyzed in a multivariable Cox proportional hazards model.ResultsThe study population consisted of 5,286 CCS, with a median follow-up of 22 years (5-50 years), of whom 59 (1.1%) had a splenectomy and 489 (9.2%) radiotherapy involving the spleen. VHD was present in 21 CCS (0.4%). The cumulative incidence of VHD at the age of 40 years was significantly higher in CCS who received treatments affecting splenic function (2.7%, 95% confidence interval (CI) 0.4%-4.9%) compared with CCS without (0.4%, 95% CI 0.1%-0.7%) (Gray's test, p = 0.003). Splenectomy was significantly associated with VHD in a multivariable analysis (hazard ratio 8.6, 95% CI 3.1-24.1).Conclusions and implicationsSplenectomy was associated with VHD. Future research is needed to determine if CCS who had a splenectomy as part of cancer treatment might benefit from screening for VHD.

Published
2024

3. A Biomarker-Based Diagnostic Model for Cardiac Dysfunction in Childhood Cancer Survivors

Author

Leerink, Jan M., Feijen, Elizabeth A.M., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, van Dalen, Elvira C., van der Heiden-van der Loo, Margriet, Bresters, Dorine, Ronckers, Cécile M., de Vries, Andrica C.H., Neggers, Sebastian, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., Kok, Wouter E.M., Leerink, Jan M., Feijen, Elizabeth A.M., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, van Dalen, Elvira C., van der Heiden-van der Loo, Margriet, Bresters, Dorine, Ronckers, Cécile M., de Vries, Andrica C.H., Neggers, Sebastian, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., and Kok, Wouter E.M.

Abstract

Background: Childhood cancer survivors at risk for heart failure undergo lifelong echocardiographic surveillance. Previous studies reported the limited diagnostic accuracy of N-terminal pro–B-type natriuretic peptide (NT-proBNP) and high-sensitivity cardiac troponin T (hs-cTnT) in detecting left ventricular (LV) dysfunction. However, potential enhanced diagnostic accuracy through the combination of biomarkers and clinical characteristics has been suggested. Objectives: The aim of this study was to develop and internally validate a diagnostic model that combines cardiac biomarkers with clinical characteristics for effectively ruling in or ruling out LV dysfunction in childhood cancer survivors. Methods: A multicenter cross-sectional study included 1,334 survivors (median age 34.2 years) and 278 siblings (median age 36.8 years). Logistic regression models were developed and validated through bootstrapping, combining biomarkers with clinical characteristics. Results: Abnormal NT-proBNP levels were observed in 22.1% of survivors compared with 5.4% of siblings, whereas hs-cTnT levels exceeding 10 ng/L were uncommon in both survivors (5.9%) and siblings (5.0%). The diagnostic models demonstrated improvement upon the addition of NT-proBNP and hs-cTnT to clinical characteristics, resulting in an increased C statistic from 0.69 to 0.73 for LV ejection fraction (LVEF) <50% and a more accurate prediction of more severe LV dysfunction, with the C statistic increasing from 0.80 to 0.86 for LVEF <45%. For LVEF <50% (prevalence 10.9%), 16.9% of survivors could be effectively ruled out with high sensitivity (95.4%; 95% CI: 90.4%-99.3%) and negative predictive value (97.5%; 95% CI: 94.6%-99.7%). Similarly, for LVEF <45% (prevalence 3.4%), 53.0% of survivors could be ruled out with moderate to high sensitivity (91.1%; 95% CI: 79.2%-100%) and high negative predictive value (99.4%; 95% CI: 98.7%-100%). Con

Published
2024

4. Presence and utility of electrocardiographic abnormalities in long-term childhood cancer survivors

Author

De Baat, Esmée C., Merkx, Remy, Leerink, Jan M., Boerhout, Coen, Van Der Pal, Heleen J.H., Van Dalen, Elvira C., Loonen, Jacqueline, Bresters, Dorine, Van Dulmen-Den Broeder, Eline, Van Der Heiden-Van Der Loo, Margriet, Van Den Heuvel, Marry M., Kok, Judith L., Louwerens, Marloes, Neggers, Sebastian J.C.M.M., Ronckers, Cecline M., Teepen, Jop C., Tissing, Wim J.E., De Vries, Andrica C., Kapusta, Livia, Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., Kok, Wouter E.M., Feijen, Elizabeth A.M., De Baat, Esmée C., Merkx, Remy, Leerink, Jan M., Boerhout, Coen, Van Der Pal, Heleen J.H., Van Dalen, Elvira C., Loonen, Jacqueline, Bresters, Dorine, Van Dulmen-Den Broeder, Eline, Van Der Heiden-Van Der Loo, Margriet, Van Den Heuvel, Marry M., Kok, Judith L., Louwerens, Marloes, Neggers, Sebastian J.C.M.M., Ronckers, Cecline M., Teepen, Jop C., Tissing, Wim J.E., De Vries, Andrica C., Kapusta, Livia, Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., Kok, Wouter E.M., and Feijen, Elizabeth A.M.

Abstract

Background: We assessed the prevalence and diagnostic value of ECG abnormalities for cardiomyopathy surveillance in childhood cancer survivors. Methods: In this cross-sectional study, 1381 survivors (≥5 years) from the Dutch Childhood Cancer Survivor Study part 2 and 272 siblings underwent a long-term follow-up ECG and echocardiography. We compared ECG abnormality prevalences using the Minnesota Code between survivors and siblings, and within biplane left ventricular ejection fraction (LVEF) categories. Among 880 survivors who received anthracycline, mitoxantrone or heart radiotherapy, logistic regression models using least absolute shrinkage and selection operator identified ECG abnormalities associated with three abnormal LVEF categories (<52% in male/<54% in female, <50% and <45%). We assessed the overall contribution of these ECG abnormalities to clinical regression models predicting abnormal LVEF, assuming an absence of systolic dysfunction with a <1% threshold probability. Results: 16% of survivors (52% female, mean age 34.7 years) and 14% of siblings had major ECG abnormalities. ECG abnormalities increased with decreasing LVEF. Integrating selected ECG data into the baseline model significantly improved prediction of sex-specific abnormal LVEF (c-statistic 0.66 vs 0.71), LVEF <50% (0.66 vs 0.76) and LVEF <45% (0.80 vs 0.86). While no survivor met the preset probability threshold in the first two models, the third model used five ECG variables to predict LVEF <45% and was applicable for ruling out (sensitivity 93%, specificity 56%, negative predictive value 99.6%). Calibration and internal validation tests performed well. Conclusion: A clinical prediction model with ECG data (left bundle branch block, left atrial enlargement, left heart axis, Cornell's criteria for left ventricular hypertrophy and heart rate) may aid in ruling out LVEF <45%.

Published
2024

5. Extensive Cardiac Function Analyses Using Contemporary Echocardiography in Childhood Cancer Survivors:A DCCSS LATER Study

Author

Merkx, Remy, Leerink, Jan M., Feijen, E. (Lieke) A.M., de Baat, Esmée C., Bellersen, Louise, Bresters, Dorine, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., Kok, Judith L., Louwerens, Marloes, Maas, Angela H.E.M., Neggers, Sebastian J.C.M.M., Ronckers, Cécile M., Teepen, Jop C., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Weijers, Gert, de Korte, Chris L., Loonen, Jacqueline, Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Kremer, Leontien C.M., Kok, Wouter E.M., Kapusta, Livia, Merkx, Remy, Leerink, Jan M., Feijen, E. (Lieke) A.M., de Baat, Esmée C., Bellersen, Louise, Bresters, Dorine, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., Kok, Judith L., Louwerens, Marloes, Maas, Angela H.E.M., Neggers, Sebastian J.C.M.M., Ronckers, Cécile M., Teepen, Jop C., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Weijers, Gert, de Korte, Chris L., Loonen, Jacqueline, Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Kremer, Leontien C.M., Kok, Wouter E.M., and Kapusta, Livia

Abstract

Background: Childhood cancer survivors (CCS) are at risk for cardiotoxicity. Objectives: We sought to assess how cardiac dysfunction measurements in CCS overlap and are differentially influenced by risk factors. Methods: This cross-sectional Dutch Childhood Cancer Survivor Study evaluated echocardiograms of 1,397 ≥5-year CCS and 277 siblings. Of CCS, n = 1,254 received cardiotoxic (anthracyclines/mitoxantrone/radiotherapy involving the heart region [RTheart]) and n = 143 received potentially cardiotoxic (cyclophosphamide, ifosfamide, or vincristine) therapy. We assessed demographic, treatment-related, and traditional cardiovascular risk factors for cardiac dysfunction using multivariable logistic regression. Results: CCS were a median of 26.7 years after diagnosis; 49% were women. Abnormal left ventricular ejection fraction (LVEF) (defined as <52% in men, <54% in women) occurred most commonly in CCS treated with anthracyclines and RTheart combined (38%). Age/sex-specific abnormal global longitudinal strain (GLS) occurred most commonly in CCS treated with RTheart, either with (41%) or without (38%) anthracyclines. Of CCS with normal LVEF, 20.2% showed abnormal GLS. Diastolic dysfunction grade ≥II was rare. Abnormal LVEF was mainly associated with female sex, anthracycline dose, and only in women, RTheart dose. Abnormal GLS was associated with female sex, RTheart dose, diastolic blood pressure, and only in women, anthracycline dose. Cyclophosphamide, ifosfamide, and vincristine were not associated with LVEF or GLS. Compared with siblings, CCS showed higher risk of abnormal LVEF (OR: 2.9; 95% CI: 1.4-6.6) and GLS (OR: 2.1; 95% CI: 1.2-3.7), independent of (potentially) cardiotoxic treatment-related and cardiovascular risk factors. Conclusions: Abnormal LVEF and GLS constitute complementary measures of systolic dysfunction among long-term CCS. Their diagnostic value may differ according to cardiotoxic expos

Published
2023

6. Comprehensive Evaluation of Pediatric Patients with Ebstein Anomaly Requires Both Echocardiography and Cardiac Magnetic Resonance Imaging

Author

Geerdink, Lianne M., van Everdingen, Wouter M., Kuipers, Irene M., Fejzic, Zina, Sarvaas, Gideon J. du Marchie, Frerich, Stefan, ter Heide, Henriette, Helbing, Willem A., de Korte, Chris L., Habets, Jesse, Kapusta, Livia, Geerdink, Lianne M., van Everdingen, Wouter M., Kuipers, Irene M., Fejzic, Zina, Sarvaas, Gideon J. du Marchie, Frerich, Stefan, ter Heide, Henriette, Helbing, Willem A., de Korte, Chris L., Habets, Jesse, and Kapusta, Livia

Abstract

With the trend towards childhood surgery in patients with Ebstein anomaly (EA), thorough imaging is crucial for patient selection. This study aimed to assess biventricular function by echocardiography and cardiac magnetic resonance (CMR) and compare EA severity classifications. Twenty-three patients (8–17 years) underwent echocardiography and CMR. Echocardiographic parameters included tricuspid annular plane systolic excursions (TAPSE), fractional area change of the functional right ventricle (fRV-FAC), fRV free wall peak systolic myocardial velocity (fRVs’), and tricuspid regurgitation (TR). End-diastolic and end-systolic volume (EDV resp. ESV), fRV- and LV ejection fraction (EF) and TR were obtained by CMR. EA severity classifications included displacement index, Celermajer index and the total-right/left-volume index. Median fRV-FAC was 38% (IQR 33–42). TAPSE and fRVs’ were reduced in 39% and 75% of the patients, respectively. Echocardiographic TR was visually graded as mild, moderate, or severe in nine, six and eight patients, respectively. By CMR, median fRVEF was 49% (IQR 36–58) and TR was graded as mild, moderate, or severe in nine, twelve and two patients, respectively. In 70% of cases, fRV-EDV was higher than LV-EDV. LVEF was decreased in 17 cases (74%). There was excellent correlation between echocardiography-derived fRV-FAC and CMR-derived fRVEF (rho = 0.812, p < 0.001). While echocardiography is a versatile tool in the complex geometry of the Ebstein heart, it has limitations. CMR offers a total overview and has the advantage of reliable volume assessment of both ventricles. Comprehensive evaluation of pediatric patients with EA may therefore require a synergistic implementation of echocardiography and CMR.

Published
2023

7. Comprehensive Evaluation of Pediatric Patients with Ebstein Anomaly Requires Both Echocardiography and Cardiac Magnetic Resonance Imaging

Author

Cardiologie patientenzorg, Cardiologie Arts-onderzoekers, Child Health, Geerdink, Lianne M, van Everdingen, Wouter M, Kuipers, Irene M, Fejzic, Zina, du Marchie Sarvaas, Gideon J, Frerich, Stefan, Ter Heide, Henriëtte, Helbing, Willem A, de Korte, Chris L, Habets, Jesse, Kapusta, Livia, Cardiologie patientenzorg, Cardiologie Arts-onderzoekers, Child Health, Geerdink, Lianne M, van Everdingen, Wouter M, Kuipers, Irene M, Fejzic, Zina, du Marchie Sarvaas, Gideon J, Frerich, Stefan, Ter Heide, Henriëtte, Helbing, Willem A, de Korte, Chris L, Habets, Jesse, and Kapusta, Livia

Published
2023

8. Candidate Plasma Biomarkers to Detect Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors:A Case Control Study in the Dutch Childhood Cancer Survivor Study

Author

Leerink, Jan M., Feijen, Elizabeth A.M., Moerland, Perry D., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, Asselbergs, Folkert W., Sammani, Arjan, Teske, Arco J., van Dalen, Elvira C., van der Heiden-Van der Loo, Margriet, van Dulmen-Den Broeder, Eline, de Vries, Andrica C.H., Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., Kok, Wouter E.M., Leerink, Jan M., Feijen, Elizabeth A.M., Moerland, Perry D., de Baat, Esmee C., Merkx, Remy, van der Pal, Helena J.H., Tissing, Wim J.E., Louwerens, Marloes, van den Heuvel-Eibrink, Marry M., Versluys, A. Birgitta, Asselbergs, Folkert W., Sammani, Arjan, Teske, Arco J., van Dalen, Elvira C., van der Heiden-Van der Loo, Margriet, van Dulmen-Den Broeder, Eline, de Vries, Andrica C.H., Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M., Kremer, Leontien C.M., Mavinkurve-Groothuis, Annelies M.C., and Kok, Wouter E.M.

Abstract

BACKGROUND: Plasma biomarkers may aid in the detection of anthracycline-related cardiomyopathy (ACMP). However, the cur-rently available biomarkers have limited diagnostic value in long-term childhood cancer survivors. This study sought to identify diagnostic plasma biomarkers for ACMP in childhood cancer survivors. METHODS AND RESULTS: We measured 275 plasma proteins in 28 ACMP cases with left ventricular ejection fraction <45%, 29 anthracycline-treated controls with left ventricular ejection fraction ≥53% matched on sex, time after cancer, and anthracy-cline dose, and 29 patients with genetically determined dilated cardiomyopathy with left ventricular ejection fraction <45%. Multivariable linear regression was used to identify differentially expressed proteins. Elastic net model, including clinical char-acteristics, was used to assess discrimination of proteins diagnostic for ACMP. NT-proBNP (N-terminal pro-B-type natriuretic peptide) and the inflammatory markers CCL19 (C-C motif chemokine ligands 19) and CCL20, PSPD (pulmonary surfactant protein-D), and PTN (pleiotrophin) were significantly upregulated in ACMP compared with controls. An elastic net model selected 45 proteins, including NT-proBNP, CCL19, CCL20 and PSPD, but not PTN, that discriminated ACMP cases from controls with an area under the receiver operating characteristic curve (AUC) of 0.78. This model was not superior to a model including NT-proBNP and clinical characteristics (AUC=0.75; P=0.766). However, when excluding 8 ACMP cases with heart failure, the full model was superior to that including only NT-proBNP and clinical characteristics (AUC=0.75 versus AUC=0.50; P=0.022). The same 45 proteins also showed good discrimination between dilated cardiomyopathy and controls (AUC=0.89), underscoring their association with cardiomyopathy. CONCLUSIONS: We identified 3 specific inflammatory proteins as candidate plasma biomarkers for ACMP in long-term childhood cancer survivors and demonstrated pro

Published
2022

9. Cardiac function in childhood cancer survivors treated with vincristine:Echocardiographic results from the DCCSS LATER 2 CARD study

Author

Merkx, Remy, Feijen, E. (Lieke) A.M., Leerink, Jan M., de Baat, Esmée C., Bellersen, Louise, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., de Korte, Chris L., Loonen, Jacqueline, Louwerens, Marloes, Ronckers, Cécile M., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Weijers, Gert, Kok, Wouter E.M., Kremer, Leontien C.M., Kapusta, Livia, Merkx, Remy, Feijen, E. (Lieke) A.M., Leerink, Jan M., de Baat, Esmée C., Bellersen, Louise, van Dalen, Elvira C., van Dulmen-den Broeder, Eline, van der Heiden-van der Loo, Margriet, van den Heuvel-Eibrink, Marry M., de Korte, Chris L., Loonen, Jacqueline, Louwerens, Marloes, Ronckers, Cécile M., Teske, Arco J., Tissing, Wim J.E., de Vries, Andrica C.H., Mavinkurve-Groothuis, Annelies M.C., van der Pal, Helena J.H., Weijers, Gert, Kok, Wouter E.M., Kremer, Leontien C.M., and Kapusta, Livia

Abstract

Background: Anthracyclines and radiotherapy involving the heart region are cardiotoxic, but the potential cardiotoxicity of vincristine remains unknown. We assessed cardiac function in vincristine-treated >5-year childhood cancer survivors (CCS). Methods and results: We cross-sectionally compared echocardiograms of 101 vincristine-treated CCS (median age 35 years [range: 17–53], median vincristine dose 63 mg/m2) from the national Dutch Childhood Cancer Survivor Study, LATER cohort, to 101 age- and sex-matched controls. CCS treated with anthracyclines, radiotherapy involving the heart region, cyclophosphamide or ifosfamide were excluded. Twelve CCS (14%) versus four controls (4%; p 0.034) had a decreased left ventricular ejection fraction (LVEF; men <52%, women <54%). Mean LVEF was 58.4% versus 59.7% (p 0.050). Global longitudinal strain (GLS) was abnormal in nineteen (24%) CCS versus eight controls (9%; p 0.011). Mean GLS was 19.0% versus 20.1% (p 0.001). No ≥grade 2 diastolic dysfunction was detected. In multivariable logistic regression analysis CCS had higher risk of abnormal GLS (OR 3.55, p 0.012), but not abnormal LVEF (OR 3.07, p 0.065), than controls. Blood pressure and smoking history contributed to variation in LVEF, whereas obesity and diastolic blood pressure contributed to variation in GLS. Cumulative vincristine dose was not associated with either abnormal LVEF or abnormal GLS in multivariable models corrected for age and sex (OR per 50 mg/m2: 0.88, p 0.85 and 1.14, p 0.82, respectively). Conclusions: Vincristine-treated long-term CCS showed an abnormal GLS more frequently than controls. Their risk for future clinical cardiac events and the role of risk factor modification should be further elucidated.

Published
2022

10. Candidate Plasma Biomarkers to Detect Anthracycline-Related Cardiomyopathy in Childhood Cancer Survivors: A Case Control Study in the Dutch Childhood Cancer Survivor Study

Author

PMC Medisch specialisten, Zorg en O&O, Child Health, Speerpunt, Haematologie patientenzorg, Team Medisch, Circulatory Health, Onderzoek Precision medicine, Leerink, Jan M, Feijen, Elizabeth A M, Moerland, Perry D, de Baat, Esmee C, Merkx, Remy, van der Pal, Helena J H, Tissing, Wim J E, Louwerens, Marloes, van den Heuvel-Eibrink, Marry M, Versluys, A Birgitta, Asselbergs, Folkert W, Sammani, Arjan, Teske, Arco J, van Dalen, Elvira C, van der Heiden-van der Loo, Margriet, van Dulmen-den Broeder, Eline, de Vries, Andrica C H, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M, Kremer, Leontien C M, Mavinkurve-Groothuis, Annelies M C, Kok, Wouter E M, PMC Medisch specialisten, Zorg en O&O, Child Health, Speerpunt, Haematologie patientenzorg, Team Medisch, Circulatory Health, Onderzoek Precision medicine, Leerink, Jan M, Feijen, Elizabeth A M, Moerland, Perry D, de Baat, Esmee C, Merkx, Remy, van der Pal, Helena J H, Tissing, Wim J E, Louwerens, Marloes, van den Heuvel-Eibrink, Marry M, Versluys, A Birgitta, Asselbergs, Folkert W, Sammani, Arjan, Teske, Arco J, van Dalen, Elvira C, van der Heiden-van der Loo, Margriet, van Dulmen-den Broeder, Eline, de Vries, Andrica C H, Kapusta, Livia, Loonen, Jacqueline, Pinto, Yigal M, Kremer, Leontien C M, Mavinkurve-Groothuis, Annelies M C, and Kok, Wouter E M

Published
2022

11. Associations between blood biomarkers, cardiac function, and adverse outcome in a young fontan cohort

Author

Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, van den Bosch, Eva, Bossers, Sjoerd S.M., Kamphuis, Vivian P., Boersma, Eric, Roos-Hesselink, Jolien W., Breur, Johannes M.P.J., Ten Harkel, Arend D.J., Kapusta, Livia, Bartelds, Beatrijs, Roest, Arno A.W., Kuipers, Irene M., Blom, Nico A., Koopman, Laurens P., Helbing, Willem A., Cardiologie onderzoek 1, Child Health, Circulatory Health, Regenerative Medicine and Stem Cells, van den Bosch, Eva, Bossers, Sjoerd S.M., Kamphuis, Vivian P., Boersma, Eric, Roos-Hesselink, Jolien W., Breur, Johannes M.P.J., Ten Harkel, Arend D.J., Kapusta, Livia, Bartelds, Beatrijs, Roest, Arno A.W., Kuipers, Irene M., Blom, Nico A., Koopman, Laurens P., and Helbing, Willem A.

Published
2021

12. Refining the 10-Year Prediction of Left Ventricular Systolic Dysfunction in Long-Term Survivors of Childhood Cancer

Author

Zorg en O&O, Child Health, Arts-assistenten Kinderen, Leerink, Jan M, van der Pal, Helena J H, Kremer, Leontien C M, Feijen, Elizabeth A M, Meregalli, Paola G, Pourier, Milanthy S, Merkx, Remy, Bellersen, Louise, van Dalen, Elvira C, Loonen, Jacqueline, Pinto, Yigal M, Kapusta, Livia, Mavinkurve-Groothuis, Annelies M C, Kok, Wouter E M, Zorg en O&O, Child Health, Arts-assistenten Kinderen, Leerink, Jan M, van der Pal, Helena J H, Kremer, Leontien C M, Feijen, Elizabeth A M, Meregalli, Paola G, Pourier, Milanthy S, Merkx, Remy, Bellersen, Louise, van Dalen, Elvira C, Loonen, Jacqueline, Pinto, Yigal M, Kapusta, Livia, Mavinkurve-Groothuis, Annelies M C, and Kok, Wouter E M

Published
2021

13. Ventricular response to dobutamine stress cardiac magnetic resonance imaging is associated with adverse outcome during 8-year follow-up in patients with repaired Tetralogy of Fallot

Author

Circulatory Health, Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, van den Bosch, Eva, Cuypers, Judith A A E, Luijnenburg, S.E., Duppen, Nienke, Boersma, Eric, Budde, Ricardo, Krestin, Gabriel P., Blom, Nico A, Breur, Hans MPJ, Snoeren, M.M., Roos-Hesselink, Jolien W, Kapusta, Livia, Helbing, Willem A., Circulatory Health, Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, van den Bosch, Eva, Cuypers, Judith A A E, Luijnenburg, S.E., Duppen, Nienke, Boersma, Eric, Budde, Ricardo, Krestin, Gabriel P., Blom, Nico A, Breur, Hans MPJ, Snoeren, M.M., Roos-Hesselink, Jolien W, Kapusta, Livia, and Helbing, Willem A.

Published
2020

14. Health-Related Quality of Life, Emotional and Behavioral Problems in Children and Adolescents with Ebstein Anomaly

Author

Cardiologie patientenzorg, Child Health, Geerdink, Lianne, van der Mheen, Malindi, du Marchie Sarvaas, Gideon J, Kuipers, Irene M., Frerich, Stefan, ter Heide, H, Helbing, Wim A, feijzic, zina, schroer, christian, de Korte, Chris, Kapusta, Livia, Verhaak, Chris, Utens, Elisabeth, Cardiologie patientenzorg, Child Health, Geerdink, Lianne, van der Mheen, Malindi, du Marchie Sarvaas, Gideon J, Kuipers, Irene M., Frerich, Stefan, ter Heide, H, Helbing, Wim A, feijzic, zina, schroer, christian, de Korte, Chris, Kapusta, Livia, Verhaak, Chris, and Utens, Elisabeth

Published
2020

15. Ventricular Response to Dobutamine Stress CMR Is a Predictor for Outcome in Fontan Patients

Author

van den Bosch, Eva, Bossers, Sjoerd S M, Robbers-Visser, Daniëlle, Boersma, Eric, Roos-Hesselink, Jolien W, Breur, Hans M P J, Blom, Nico A, Kroft, Lucia J M, Snoeren, Miranda M, Kapusta, Livia, Helbing, Willem A, van den Bosch, Eva, Bossers, Sjoerd S M, Robbers-Visser, Daniëlle, Boersma, Eric, Roos-Hesselink, Jolien W, Breur, Hans M P J, Blom, Nico A, Kroft, Lucia J M, Snoeren, Miranda M, Kapusta, Livia, and Helbing, Willem A

Published
2019

16. Ventricular Response to Dobutamine Stress CMR Is a Predictor for Outcome in Fontan Patients

Author

van den Bosch, Eva, Bossers, Sjoerd S M, Robbers-Visser, Daniëlle, Boersma, Eric, Roos-Hesselink, Jolien W, Breur, Hans M P J, Blom, Nico A, Kroft, Lucia J M, Snoeren, Miranda M, Kapusta, Livia, Helbing, Willem A, van den Bosch, Eva, Bossers, Sjoerd S M, Robbers-Visser, Daniëlle, Boersma, Eric, Roos-Hesselink, Jolien W, Breur, Hans M P J, Blom, Nico A, Kroft, Lucia J M, Snoeren, Miranda M, Kapusta, Livia, and Helbing, Willem A

Published
2019

17. Ventricular Response to Dobutamine Stress CMR Is a Predictor for Outcome in Fontan Patients

Author

van den Bosch, Eva, Bossers, Sjoerd S M, Robbers-Visser, Daniëlle, Boersma, Eric, Roos-Hesselink, Jolien W, Breur, Hans M P J, Blom, Nico A, Kroft, Lucia J M, Snoeren, Miranda M, Kapusta, Livia, Helbing, Willem A, van den Bosch, Eva, Bossers, Sjoerd S M, Robbers-Visser, Daniëlle, Boersma, Eric, Roos-Hesselink, Jolien W, Breur, Hans M P J, Blom, Nico A, Kroft, Lucia J M, Snoeren, Miranda M, Kapusta, Livia, and Helbing, Willem A

Published
2019

18. Ventricular Response to Dobutamine Stress CMR Is a Predictor for Outcome in Fontan Patients

Author

Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, van den Bosch, Eva, Bossers, Sjoerd S M, Robbers-Visser, Daniëlle, Boersma, Eric, Roos-Hesselink, Jolien W, Breur, Hans M P J, Blom, Nico A, Kroft, Lucia J M, Snoeren, Miranda M, Kapusta, Livia, Helbing, Willem A, Cardiologie onderzoek 1, Child Health, Regenerative Medicine and Stem Cells, van den Bosch, Eva, Bossers, Sjoerd S M, Robbers-Visser, Daniëlle, Boersma, Eric, Roos-Hesselink, Jolien W, Breur, Hans M P J, Blom, Nico A, Kroft, Lucia J M, Snoeren, Miranda M, Kapusta, Livia, and Helbing, Willem A

Published
2019

19. Does functional health status predict health-related quality of life in children after Fontan operation?

Author

Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, Helbing, Willem A., Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, and Helbing, Willem A.

Published
2016

20. AGORA, a data- and biobank for birth defects and childhood cancer

Author

van Rooij, Iris A L M, van der Zanden, Loes F M, Bongers, Ernie M H F, Renkema, Kirsten Y, Wijers, Charlotte H W, Thonissen, Michelle, Dokter, Elisabeth M J, Marcelis, Carlo L M, de Blaauw, Ivo, Wijnen, Marc H W A, Hoogerbrugge, Peter M, Bokkerink, Jos P M, Schreuder, Michiel F, Koster-Kamphuis, Linda, Cornelissen, Elisabeth A M, Kapusta, Livia, van Heijst, Arno F J, Liem, Kian D, de Gier, Robert P E, Kuijpers-Jagtman, Anne Marie, Admiraal, Ronald J C, Bergé, Stefaan J, van der Biezen, Jan Jaap, Verdonck, An, Vander Poorten, Vincent, Hens, Greet, Roosenboom, Jasmien, Lilien, Marc R, de Jong, Tom P, Broens, Paul, Wijnen, Rene, Brooks, Alice, Franke, Barbara, Brunner, Han G, Carels, Carine E L, Knoers, Nine V A M, Feitz, Wout F J, Roeleveld, Nel, van Rooij, Iris A L M, van der Zanden, Loes F M, Bongers, Ernie M H F, Renkema, Kirsten Y, Wijers, Charlotte H W, Thonissen, Michelle, Dokter, Elisabeth M J, Marcelis, Carlo L M, de Blaauw, Ivo, Wijnen, Marc H W A, Hoogerbrugge, Peter M, Bokkerink, Jos P M, Schreuder, Michiel F, Koster-Kamphuis, Linda, Cornelissen, Elisabeth A M, Kapusta, Livia, van Heijst, Arno F J, Liem, Kian D, de Gier, Robert P E, Kuijpers-Jagtman, Anne Marie, Admiraal, Ronald J C, Bergé, Stefaan J, van der Biezen, Jan Jaap, Verdonck, An, Vander Poorten, Vincent, Hens, Greet, Roosenboom, Jasmien, Lilien, Marc R, de Jong, Tom P, Broens, Paul, Wijnen, Rene, Brooks, Alice, Franke, Barbara, Brunner, Han G, Carels, Carine E L, Knoers, Nine V A M, Feitz, Wout F J, and Roeleveld, Nel

Published
2016

21. AGORA, a data- and biobank for birth defects and childhood cancer

Author

van Rooij, Iris A L M, van der Zanden, Loes F M, Bongers, Ernie M H F, Renkema, Kirsten Y, Wijers, Charlotte H W, Thonissen, Michelle, Dokter, Elisabeth M J, Marcelis, Carlo L M, de Blaauw, Ivo, Wijnen, Marc H W A, Hoogerbrugge, Peter M, Bokkerink, Jos P M, Schreuder, Michiel F, Koster-Kamphuis, Linda, Cornelissen, Elisabeth A M, Kapusta, Livia, van Heijst, Arno F J, Liem, Kian D, de Gier, Robert P E, Kuijpers-Jagtman, Anne Marie, Admiraal, Ronald J C, Bergé, Stefaan J, van der Biezen, Jan Jaap, Verdonck, An, Vander Poorten, Vincent, Hens, Greet, Roosenboom, Jasmien, Lilien, Marc R, de Jong, Tom P, Broens, Paul, Wijnen, Rene, Brooks, Alice, Franke, Barbara, Brunner, Han G, Carels, Carine E L, Knoers, Nine V A M, Feitz, Wout F J, Roeleveld, Nel, van Rooij, Iris A L M, van der Zanden, Loes F M, Bongers, Ernie M H F, Renkema, Kirsten Y, Wijers, Charlotte H W, Thonissen, Michelle, Dokter, Elisabeth M J, Marcelis, Carlo L M, de Blaauw, Ivo, Wijnen, Marc H W A, Hoogerbrugge, Peter M, Bokkerink, Jos P M, Schreuder, Michiel F, Koster-Kamphuis, Linda, Cornelissen, Elisabeth A M, Kapusta, Livia, van Heijst, Arno F J, Liem, Kian D, de Gier, Robert P E, Kuijpers-Jagtman, Anne Marie, Admiraal, Ronald J C, Bergé, Stefaan J, van der Biezen, Jan Jaap, Verdonck, An, Vander Poorten, Vincent, Hens, Greet, Roosenboom, Jasmien, Lilien, Marc R, de Jong, Tom P, Broens, Paul, Wijnen, Rene, Brooks, Alice, Franke, Barbara, Brunner, Han G, Carels, Carine E L, Knoers, Nine V A M, Feitz, Wout F J, and Roeleveld, Nel

Published
2016

22. Does functional health status predict health-related quality of life in children after Fontan operation?

Author

Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, Helbing, Willem A., Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, and Helbing, Willem A.

Published
2016

23. AGORA, a data- and biobank for birth defects and childhood cancer

Author

van Rooij, Iris A L M, van der Zanden, Loes F M, Bongers, Ernie M H F, Renkema, Kirsten Y, Wijers, Charlotte H W, Thonissen, Michelle, Dokter, Elisabeth M J, Marcelis, Carlo L M, de Blaauw, Ivo, Wijnen, Marc H W A, Hoogerbrugge, Peter M, Bokkerink, Jos P M, Schreuder, Michiel F, Koster-Kamphuis, Linda, Cornelissen, Elisabeth A M, Kapusta, Livia, van Heijst, Arno F J, Liem, Kian D, de Gier, Robert P E, Kuijpers-Jagtman, Anne Marie, Admiraal, Ronald J C, Bergé, Stefaan J, van der Biezen, Jan Jaap, Verdonck, An, Vander Poorten, Vincent, Hens, Greet, Roosenboom, Jasmien, Lilien, Marc R, de Jong, Tom P, Broens, Paul, Wijnen, Rene, Brooks, Alice, Franke, Barbara, Brunner, Han G, Carels, Carine E L, Knoers, Nine V A M, Feitz, Wout F J, Roeleveld, Nel, van Rooij, Iris A L M, van der Zanden, Loes F M, Bongers, Ernie M H F, Renkema, Kirsten Y, Wijers, Charlotte H W, Thonissen, Michelle, Dokter, Elisabeth M J, Marcelis, Carlo L M, de Blaauw, Ivo, Wijnen, Marc H W A, Hoogerbrugge, Peter M, Bokkerink, Jos P M, Schreuder, Michiel F, Koster-Kamphuis, Linda, Cornelissen, Elisabeth A M, Kapusta, Livia, van Heijst, Arno F J, Liem, Kian D, de Gier, Robert P E, Kuijpers-Jagtman, Anne Marie, Admiraal, Ronald J C, Bergé, Stefaan J, van der Biezen, Jan Jaap, Verdonck, An, Vander Poorten, Vincent, Hens, Greet, Roosenboom, Jasmien, Lilien, Marc R, de Jong, Tom P, Broens, Paul, Wijnen, Rene, Brooks, Alice, Franke, Barbara, Brunner, Han G, Carels, Carine E L, Knoers, Nine V A M, Feitz, Wout F J, and Roeleveld, Nel

Published
2016

24. Does functional health status predict health-related quality of life in children after Fontan operation?

Author

Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, Helbing, Willem A., Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, and Helbing, Willem A.

Published
2016

25. AGORA, a data- and biobank for birth defects and childhood cancer

Author

Genetica Groep Van Tintelen, Child Health, PMC Medisch specialisten, Nefrologie, Urologie Medisch Kinderen, Other research (not in main researchprogram), Genetica, van Rooij, Iris A L M, van der Zanden, Loes F M, Bongers, Ernie M H F, Renkema, Kirsten Y, Wijers, Charlotte H W, Thonissen, Michelle, Dokter, Elisabeth M J, Marcelis, Carlo L M, de Blaauw, Ivo, Wijnen, Marc H W A, Hoogerbrugge, Peter M, Bokkerink, Jos P M, Schreuder, Michiel F, Koster-Kamphuis, Linda, Cornelissen, Elisabeth A M, Kapusta, Livia, van Heijst, Arno F J, Liem, Kian D, de Gier, Robert P E, Kuijpers-Jagtman, Anne Marie, Admiraal, Ronald J C, Bergé, Stefaan J, van der Biezen, Jan Jaap, Verdonck, An, Vander Poorten, Vincent, Hens, Greet, Roosenboom, Jasmien, Lilien, Marc R, de Jong, Tom P, Broens, Paul, Wijnen, Rene, Brooks, Alice, Franke, Barbara, Brunner, Han G, Carels, Carine E L, Knoers, Nine V A M, Feitz, Wout F J, Roeleveld, Nel, Genetica Groep Van Tintelen, Child Health, PMC Medisch specialisten, Nefrologie, Urologie Medisch Kinderen, Other research (not in main researchprogram), Genetica, van Rooij, Iris A L M, van der Zanden, Loes F M, Bongers, Ernie M H F, Renkema, Kirsten Y, Wijers, Charlotte H W, Thonissen, Michelle, Dokter, Elisabeth M J, Marcelis, Carlo L M, de Blaauw, Ivo, Wijnen, Marc H W A, Hoogerbrugge, Peter M, Bokkerink, Jos P M, Schreuder, Michiel F, Koster-Kamphuis, Linda, Cornelissen, Elisabeth A M, Kapusta, Livia, van Heijst, Arno F J, Liem, Kian D, de Gier, Robert P E, Kuijpers-Jagtman, Anne Marie, Admiraal, Ronald J C, Bergé, Stefaan J, van der Biezen, Jan Jaap, Verdonck, An, Vander Poorten, Vincent, Hens, Greet, Roosenboom, Jasmien, Lilien, Marc R, de Jong, Tom P, Broens, Paul, Wijnen, Rene, Brooks, Alice, Franke, Barbara, Brunner, Han G, Carels, Carine E L, Knoers, Nine V A M, Feitz, Wout F J, and Roeleveld, Nel

Published
2016

26. Does functional health status predict health-related quality of life in children after Fontan operation?

Author

Cardiologie patientenzorg, Other research (not in main researchprogram), Kinderbewegingszorg patientenzorg, Child Health, Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, Helbing, Willem A., Cardiologie patientenzorg, Other research (not in main researchprogram), Kinderbewegingszorg patientenzorg, Child Health, Dulfer, Karolijn, Bossers, Sjoerd S M, Utens, Elisabeth M W J, Duppen, Nienke, Kuipers, Irene M., Kapusta, Livia, van Iperen-Schutte, Gabrielle, Schokking, Michiel, ten Harkel, Arend D J, Takken, Tim, and Helbing, Willem A.

Published
2016

27. Comprehensive rhythm evaluation in a large contemporary Fontan population

Author

Bossers, Sjoerd S. M., Duppen, Nienke, Kapusta, Livia, Maan, Arie C., Duim, Anouk R., Bogers, Ad J. J. C., Hazekamp, Mark G., van Iperen, Gabrielle, Helbing, Willem A., Blom, Nico A, Bossers, Sjoerd S. M., Duppen, Nienke, Kapusta, Livia, Maan, Arie C., Duim, Anouk R., Bogers, Ad J. J. C., Hazekamp, Mark G., van Iperen, Gabrielle, Helbing, Willem A., and Blom, Nico A

Published
2015

28. Comprehensive rhythm evaluation in a large contemporary Fontan population

Author

Bossers, Sjoerd S. M., Duppen, Nienke, Kapusta, Livia, Maan, Arie C., Duim, Anouk R., Bogers, Ad J. J. C., Hazekamp, Mark G., van Iperen, Gabrielle, Helbing, Willem A., Blom, Nico A, Bossers, Sjoerd S. M., Duppen, Nienke, Kapusta, Livia, Maan, Arie C., Duim, Anouk R., Bogers, Ad J. J. C., Hazekamp, Mark G., van Iperen, Gabrielle, Helbing, Willem A., and Blom, Nico A

Published
2015

29. Comprehensive rhythm evaluation in a large contemporary Fontan population

Author

Bossers, Sjoerd S. M., Duppen, Nienke, Kapusta, Livia, Maan, Arie C., Duim, Anouk R., Bogers, Ad J. J. C., Hazekamp, Mark G., van Iperen, Gabrielle, Helbing, Willem A., Blom, Nico A, Bossers, Sjoerd S. M., Duppen, Nienke, Kapusta, Livia, Maan, Arie C., Duim, Anouk R., Bogers, Ad J. J. C., Hazekamp, Mark G., van Iperen, Gabrielle, Helbing, Willem A., and Blom, Nico A

Published
2015

30. Comprehensive rhythm evaluation in a large contemporary Fontan population

Author

Cardiologie patientenzorg, Other research (not in main researchprogram), Bossers, Sjoerd S. M., Duppen, Nienke, Kapusta, Livia, Maan, Arie C., Duim, Anouk R., Bogers, Ad J. J. C., Hazekamp, Mark G., van Iperen, Gabrielle, Helbing, Willem A., Blom, Nico A, Cardiologie patientenzorg, Other research (not in main researchprogram), Bossers, Sjoerd S. M., Duppen, Nienke, Kapusta, Livia, Maan, Arie C., Duim, Anouk R., Bogers, Ad J. J. C., Hazekamp, Mark G., van Iperen, Gabrielle, Helbing, Willem A., and Blom, Nico A

Published
2015

31. Long-term cognitive and cardiac outcomes after prenatal exposure to chemotherapy in children aged 18 months or older: an observational study

Author

UCL - (SLuc) Service d'obstétrique, Amant, Frédéric, Van Calsteren, Kristel, Halaska, Michael J, Mhallem Gziri, Mina, Hui, Wei, Lagae, Lieven, Willemsen, Michèl A, Kapusta, Livia, Van Calster, Ben, Wouters, Heidi, Heyns, Liesbeth, Han, Sileny N, Tomek, Viktor, Mertens, Luc, Ottevanger, Petronella B, UCL - (SLuc) Service d'obstétrique, Amant, Frédéric, Van Calsteren, Kristel, Halaska, Michael J, Mhallem Gziri, Mina, Hui, Wei, Lagae, Lieven, Willemsen, Michèl A, Kapusta, Livia, Van Calster, Ben, Wouters, Heidi, Heyns, Liesbeth, Han, Sileny N, Tomek, Viktor, Mertens, Luc, and Ottevanger, Petronella B

Abstract

BACKGROUND: Chemotherapy for the treatment of maternal cancers during pregnancy has become more acceptable in the past decade; however, the effect of prenatal exposure to chemotherapy on cardiac and neurodevelopmental outcomes of the offspring is still uncertain. We aimed to record the general health, cardiac function, and neurodevelopmental outcomes of children who were prenatally exposed to chemotherapy. METHODS: We did an interim analysis of a multicentre observational cohort study assessing children who were prenatally exposed to maternal cancer staging and treatment, including chemotherapy. We assessed children at birth, at age 18 months, and at age 5-6, 8-9, 11-12, 14-15, or 18 years. We did clinical neurological examinations, tests of the general level of cognitive functioning (Bayley or intelligence quotient [IQ] test), electrocardiography and echocardiography, and administered a questionnaire on general health and development. From age 5 years, we also did audiometry, the Auditory Verbal Learning Test, and subtasks of the Children's Memory Scale, and the Test of Everyday Attention for Children, and we also completed the Child Behavior Checklist. This study is registered with ClinicalTrials.gov, number NCT00330447. FINDINGS: 236 cycles of chemotherapy were administered in 68 pregnancies. We assessed 70 children, born at a median gestational age of 35·7 weeks (range 28·3-41·0; IQR 3·3; 47 women at <37 weeks), with a median follow-up period of 22·3 months (range 16·8-211·6; IQR 54·9). Although neurocognitive outcomes were within normal ranges, cognitive development scores were lower for children who were born preterm than for those born at full term. When controlling for age, sex, and country, the score for IQ increased by an average 11·6 points (95% CI 6·0-17·1) for each additional month of gestation (p<0·0001). Our measurements of the children's behaviour, general health, hearing, and growth corresponded with those of the general population. Cardiac dimensio

Published
2012

Catalog

Books, media, physical & digital resources
See catalog results