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6 results on '"Kawakita, T."'

1. Immunogenicity and protective efficacy of a co-formulated two-in-one inactivated whole virus particle COVID-19/influenza vaccine

Author

Handabile, C, Ohno, M, Sekiya, T, Nomura, N, Kawakita, T, Kawahara, M, Endo, M, Nishimura, T, Okumura, M, Toba, S, Sasaki, M, Orba, Y, Chua, BY, Rowntree, LC, Nguyen, THO, Shingai, M, Sato, A, Sawa, H, Ogasawara, K, Kedzierska, K, Kida, H, Handabile, C, Ohno, M, Sekiya, T, Nomura, N, Kawakita, T, Kawahara, M, Endo, M, Nishimura, T, Okumura, M, Toba, S, Sasaki, M, Orba, Y, Chua, BY, Rowntree, LC, Nguyen, THO, Shingai, M, Sato, A, Sawa, H, Ogasawara, K, Kedzierska, K, and Kida, H

Abstract

Due to the synchronous circulation of seasonal influenza viruses and severe acute respiratory coronavirus 2 (SARS-CoV-2) which causes coronavirus disease 2019 (COVID-19), there is need for routine vaccination for both COVID-19 and influenza to reduce disease severity. Here, we prepared individual WPVs composed of formalin-inactivated SARS-CoV-2 WK 521 (Ancestral strain; Co WPV) or influenza virus [A/California/07/2009 (X-179A) (H1N1) pdm; Flu WPV] to produce a two-in-one Co/Flu WPV. Serum analysis from vaccinated mice revealed that a single dose of Co/Flu WPV induced antigen-specific neutralizing antibodies against both viruses, similar to those induced by either type of WPV alone. Following infection with either virus, mice vaccinated with Co/Flu WPV showed no weight loss, reduced pneumonia and viral titers in the lung, and lower gene expression of proinflammatory cytokines, as observed with individual WPV-vaccinated. Furthermore, a pentavalent vaccine (Co/qFlu WPV) comprising of Co WPV and quadrivalent influenza vaccine (qFlu WPV) was immunogenic and protected animals from severe COVID-19. These results suggest that a single dose of the two-in-one WPV provides efficient protection against SARS-CoV-2 and influenza virus infections with no evidence of vaccine interference in mice. We propose that concomitant vaccination with the two-in-one WPV can be useful for controlling both diseases.

Published
2024

2. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: Results of aggregate and individual patient data meta-analyses

Author

Ovadia, C, Seed, P, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiu, M, Grymowicz, M, Gunaydin, B, Hague, W, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, A, Kebapcilar, L, Kondrackiene, J, Koster, M, Kowalska-Kanka, A, Kupcinskas, L, Lee, R, Locatelli, A, Macias, R, Marschall, H, Oudijk, M, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Abide, C, Yenidede, I, Thornton, J, Chappell, L, Williamson, C, Ovadia C., Seed P. T., Sklavounos A., Geenes V., Di Illio C., Chambers J., Kohari K., Bacq Y., Bozkurt N., Brun-Furrer R., Bull L., Estiu M. C., Grymowicz M., Gunaydin B., Hague W. M., Haslinger C., Hu Y., Kawakita T., Kebapcilar A. G., Kebapcilar L., Kondrackiene J., Koster M. P. H., Kowalska-Kanka A., Kupcinskas L., Lee R. H., Locatelli A., Macias R. I. R., Marschall H. -U., Oudijk M. A., Raz Y., Rimon E., Shan D., Shao Y., Tribe R., Tripodi V., Abide C. Y., Yenidede I., Thornton J. G., Chappell L. C., Williamson C., Ovadia, C, Seed, P, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiu, M, Grymowicz, M, Gunaydin, B, Hague, W, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, A, Kebapcilar, L, Kondrackiene, J, Koster, M, Kowalska-Kanka, A, Kupcinskas, L, Lee, R, Locatelli, A, Macias, R, Marschall, H, Oudijk, M, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Abide, C, Yenidede, I, Thornton, J, Chappell, L, Williamson, C, Ovadia C., Seed P. T., Sklavounos A., Geenes V., Di Illio C., Chambers J., Kohari K., Bacq Y., Bozkurt N., Brun-Furrer R., Bull L., Estiu M. C., Grymowicz M., Gunaydin B., Hague W. M., Haslinger C., Hu Y., Kawakita T., Kebapcilar A. G., Kebapcilar L., Kondrackiene J., Koster M. P. H., Kowalska-Kanka A., Kupcinskas L., Lee R. H., Locatelli A., Macias R. I. R., Marschall H. -U., Oudijk M. A., Raz Y., Rimon E., Shan D., Shao Y., Tribe R., Tripodi V., Abide C. Y., Yenidede I., Thornton J. G., Chappell L. C., and Williamson C.

Published
2019

3. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers

Author

Ovadia, C., Seed, P.T. (P.), Sklavounos, A., Geenes, V., Di Illio, C., Chambers, J. (John), Kohari, K., Bacq, Y., Bozkurt, N., Brun-Furrer, R., Bull, I.D. (Ian), Estiu, M.C., Grymowicz, M., Gunaydin, B., Hague, W.M., Haslinger, C., Hu, Y. (Yu), Kawakita, T., Kebapcilar, A.G., Kebapcilar, L., Kondrackiene, J. (Jurate), Koster, M.P.H., Kowalska-Kanka, A., Kupcinskas, L. (Limas), Lee, R.H., Locatelli, A. (Alberta), Macias, R.I.R., Marschall, H.-U., Oudijk, M.A. (Martijn), Raz, Y., Rimon, E., Shan, D., Shao, Y, Tribe, R., Tripodi, V., Abide, C.Y., Yenidede, I., Thornton, J.G. (Jim), Chappell, LC, Williamson, C. (Catherine), Ovadia, C., Seed, P.T. (P.), Sklavounos, A., Geenes, V., Di Illio, C., Chambers, J. (John), Kohari, K., Bacq, Y., Bozkurt, N., Brun-Furrer, R., Bull, I.D. (Ian), Estiu, M.C., Grymowicz, M., Gunaydin, B., Hague, W.M., Haslinger, C., Hu, Y. (Yu), Kawakita, T., Kebapcilar, A.G., Kebapcilar, L., Kondrackiene, J. (Jurate), Koster, M.P.H., Kowalska-Kanka, A., Kupcinskas, L. (Limas), Lee, R.H., Locatelli, A. (Alberta), Macias, R.I.R., Marschall, H.-U., Oudijk, M.A. (Martijn), Raz, Y., Rimon, E., Shan, D., Shao, Y, Tribe, R., Tripodi, V., Abide, C.Y., Yenidede, I., Thornton, J.G. (Jim), Chappell, LC, and Williamson, C. (Catherine)

Abstract

__Background__ Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with increased serum bile acid concentrations and determine whether elevated bile acid concentrations were associated with the risk of stillbirth and preterm birth. __Methods__ We did a systematic review by searching PubMed, Web of Science, and Embase databases for studies published from database inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile acid concentrations were available. Inclusion criteria were studies defining intrahepatic cholestasis of pregnancy based upon pruritus and elevated serum bile acid concentrations, with or without raised liver aminotransferase concentrations. Eligible studies were case-control, cohort, and populationbased studies, and randomised controlled trials, with at least 30 participants, and that reported bile acid concentrations and perinatal outcomes. Studies at potential higher risk of reporter bias were excluded, including case reports, studies not comprising cohorts, or successive cases seen in a unit; we also excluded studies with high risk of bias from groups selected (eg, a subgroup of babies with poor outcomes were explicitly excluded), conference abstracts, and Letters to the Editor without clear peer review. We also included unpublished data from two UK hospitals. We did a random effects meta-analysis to determine risk of adverse perinatal outcomes. Aggregate data for maternal and perinatal outcomes were extracted from case-control studies, and individual patient data (IPD) were requested from study authors for all types of study (as no control group was required for the IPD analysis) to assess associations between biochemical markers and adverse outcomes using logisti

Published
2019
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4. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses

Author

Ovadia, C, Seed, P, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiú, M, Grymowicz, M, Gunaydin, B, Hague, W, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, A, Kebapcilar, L, Kondrackienė, J, Koster, M, Kowalska-Kańka, A, Kupčinskas, L, Lee, R, Locatelli, A, Macias, R, Marschall, H, Oudijk, M, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Yayla Abide, C, Yenidede, I, Thornton, J, Chappell, L, Williamson, C, Seed, PT, Estiú, MC, Hague, WM, Kebapcilar, AG, Kondrackienė, Jūratė, Koster, Maria P H, Kowalska-Kańka, Aneta, Kupčinskas, Limas, Lee, Richard H, Macias, RIR, Marschall, HU, Oudijk, MA, Thornton, JG, Chappell, LC, Ovadia, C, Seed, P, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiú, M, Grymowicz, M, Gunaydin, B, Hague, W, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, A, Kebapcilar, L, Kondrackienė, J, Koster, M, Kowalska-Kańka, A, Kupčinskas, L, Lee, R, Locatelli, A, Macias, R, Marschall, H, Oudijk, M, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Yayla Abide, C, Yenidede, I, Thornton, J, Chappell, L, Williamson, C, Seed, PT, Estiú, MC, Hague, WM, Kebapcilar, AG, Kondrackienė, Jūratė, Koster, Maria P H, Kowalska-Kańka, Aneta, Kupčinskas, Limas, Lee, Richard H, Macias, RIR, Marschall, HU, Oudijk, MA, Thornton, JG, and Chappell, LC

Abstract

Background: Intrahepatic cholestasis of pregnancy is associated with adverse perinatal outcomes, but the association with the concentration of specific biochemical markers is unclear. We aimed to quantify the adverse perinatal effects of intrahepatic cholestasis of pregnancy in women with increased serum bile acid concentrations and determine whether elevated bile acid concentrations were associated with the risk of stillbirth and preterm birth. Methods: We did a systematic review by searching PubMed, Web of Science, and Embase databases for studies published from database inception to June 1, 2018, reporting perinatal outcomes for women with intrahepatic cholestasis of pregnancy when serum bile acid concentrations were available. Inclusion criteria were studies defining intrahepatic cholestasis of pregnancy based upon pruritus and elevated serum bile acid concentrations, with or without raised liver aminotransferase concentrations. Eligible studies were case-control, cohort, and population-based studies, and randomised controlled trials, with at least 30 participants, and that reported bile acid concentrations and perinatal outcomes. Studies at potential higher risk of reporter bias were excluded, including case reports, studies not comprising cohorts, or successive cases seen in a unit; we also excluded studies with high risk of bias from groups selected (eg, a subgroup of babies with poor outcomes were explicitly excluded), conference abstracts, and Letters to the Editor without clear peer review. We also included unpublished data from two UK hospitals. We did a random effects meta-analysis to determine risk of adverse perinatal outcomes. Aggregate data for maternal and perinatal outcomes were extracted from case-control studies, and individual patient data (IPD) were requested from study authors for all types of study (as no control group was required for the IPD analysis) to assess associations between biochemical markers and adverse outcomes using logistic and

Published
2019

5. Association of adverse perinatal outcomes of intrahepatic cholestasis of pregnancy with biochemical markers: results of aggregate and individual patient data meta-analyses

Author

Ovadia, C, Seed, PT, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiu, MC, Grymowicz, M, Gunaydin, B, Hague, WM, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, AG, Kebapcilar, L, Kondrackiene, J, Koster, Wendy, Kowalska-Kanka, A, Kupcinskas, L, Lee, RH, Locatelli, A (Alberta), Macias, RIR, Marschall, HU, Oudijk, MA, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Abide, CY, Yenidede, I, Thornton, JG, Chappell, LC, Williamson, C, Ovadia, C, Seed, PT, Sklavounos, A, Geenes, V, Di Illio, C, Chambers, J, Kohari, K, Bacq, Y, Bozkurt, N, Brun-Furrer, R, Bull, L, Estiu, MC, Grymowicz, M, Gunaydin, B, Hague, WM, Haslinger, C, Hu, Y, Kawakita, T, Kebapcilar, AG, Kebapcilar, L, Kondrackiene, J, Koster, Wendy, Kowalska-Kanka, A, Kupcinskas, L, Lee, RH, Locatelli, A (Alberta), Macias, RIR, Marschall, HU, Oudijk, MA, Raz, Y, Rimon, E, Shan, D, Shao, Y, Tribe, R, Tripodi, V, Abide, CY, Yenidede, I, Thornton, JG, Chappell, LC, and Williamson, C

Published
2019

6. Genetic basis of myeloid transformation in familial platelet disorder/acute myeloid leukemia patients with haploinsufficient RUNX1 allele

Author

Sakurai, M., Kasahara, H., Yoshida, K., Yoshimi, A., Kunimoto, H., Watanabe, N., Shiraishi, Y., Chiba, K., Tanaka, H., Harada, Y., Harada, H., Kawakita, T., Kurokawa, M., Miyano, S., Takahashi, S., Ogawa, S., Okamoto, S., Nakajima, H., Sakurai, M., Kasahara, H., Yoshida, K., Yoshimi, A., Kunimoto, H., Watanabe, N., Shiraishi, Y., Chiba, K., Tanaka, H., Harada, Y., Harada, H., Kawakita, T., Kurokawa, M., Miyano, S., Takahashi, S., Ogawa, S., Okamoto, S., and Nakajima, H.

Published
2016

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