Search

OBJECTIVES: The F386L PSEN1 variant has been reported in 1 Japanese family with limited clinical information. We aimed to prove that F386L is pathogenic by demonstrating that it segregates with early-onset Alzheimer disease (AD). METHODS: Eight individuals in a South Asian family provided DNA for genetic testing and underwent a neurologic examination. RESULTS: The female proband was diagnosed with AD at age 45 years and died at age 49 years. She had a CSF biomarker profile consistent with AD, and her florbetaben PET scan was amyloid positive with high uptake in the striatum. Her MRI showed no prominent white matter disease. Her affected relatives had an age at onset range of 38-57 years and had imaging and biomarker profiles similar to hers. DISCUSSION: The results presented here, in conjunction with the prior report, confirm the pathogenicity of F386L. Furthermore, our study highlights the importance of studying families from underrepresented populations to identify or confirm the pathogenicity of rare variants that may be specific to certain genetic ancestries.

Research indicates that effective learner-centred feedback requires learner agency, impact and sensemaking. While scholars are focusing on supporting agency and impact, limited research has addressed sensemaking. This is problematic, because if learners fail to understand feedback, impact is likely to be reduced. In response, this study examines (non) alignment between teacher intent and student sensemaking of authentic feedback comments. The sample included four teachers and eighteen students from two Australian universities. Data were collected via stimulated recall interviews and a feedback coding task. The results suggest that sensemaking of strength-based comments, critiques and actionable information was aided when the comments were clear and specific. On the other hand, sensemaking was limited when comments were designed to mitigate against negative affect, overloaded with multiple intentions, or overly brief. This study informs theory around learner-centred feedback design which, in turn, improves the likelihood that teacher comments will be interpreted accurately by learners.

$\kappa$CrB is a ${\sim}2.5\,$Gyr old K1 sub-giant star, with an eccentric exo-Jupiter at ${\sim}2.8\,$au and a debris disc at tens of au. We present ALMA Band 6 ($1.3\,$mm) and HST scattered light ($0.6\,\mu$m) images, demonstrating $\kappa$CrB's broad debris disc, covering an extent $50{-}180\,$au in the millimetre (peaking at $110\,$au), and $51{-}280\,$au in scattered light (peaking at $73\,$au). By modelling the millimetre emission, we estimate the dust mass as ${\sim}0.016\,M{\oplus}$, and constrain lower-limit planetesimal sizes as $D_{\rm{max}}{>}1\,$km and the planetesimal belt mass as $M_{\rm{disc}}{>}1\,M_{\oplus}$. We constrain the properties of an outer body causing a linear trend in 17 years of radial velocity data to have a semi-major axis $8{-}66\,$au and a mass $(0.4{-}120)\,M_{\rm{Jup}}$. There is a large inner cavity seen in the millimetre emission, which we show is consistent with carving by such an outer massive companion with a string of lower mass planets. Our scattered light modelling shows that the dust must have a high anisotropic scattering factor ($g{\sim}0.8{-}0.9$) but an inclination ($i{\sim}30{-}40\,$degrees) that is inferred to be significantly lower than the $i{\sim}61\,$degrees millimetre inclination. The origin of such a discrepancy is unclear, but could be caused by a misalignment in the micron and millimetre sized dust. We place an upper limit on the CO gas mass of $M_{\rm{CO}}{<}(4.2{-}13){\times}10^{-7}\,M_{\oplus}$, and show this to be consistent with levels expected from planetesimal collisions, or from CO-ice sublimation as $\kappa$CrB begins its giant branch ascent., Comment: Accepted for publication in MNRAS. 21 pages, 14 figures

We introduce our Radial Velocity Survey for Planets around Young stars (RVSPY), characterise our target stars, and search for substellar companions at orbital separations smaller than a few au from the host star. We use the FEROS spectrograph to obtain high signal-to-noise spectra and time series of precise radial velocities (RVs) of 111 stars most of which are surrounded by debris discs. Our target stars have spectral types between early F and late K, a median age of 400 Myr, and a median distance of 45 pc. We determine for all target stars their basic stellar parameters and present the results of the high-cadence RV survey and activity characterization. We achieve a median single-measurement RV precision of 6 m/s and derive the short-term intrinsic RV scatter of our targets (median 22 m/s), which is mostly caused by stellar activity and decays with age from >100 m/s at <20 Myr to <20 m/s at >500 Myr. We discover six previously unknown close companions with orbital periods between 10 and 100 days, three of which are low-mass stars, and three are in the brown dwarf mass regime. We detect no hot companion with an orbital period <10 days down to a median mass limit of ~1 M_Jup for stars younger than 500 Myr, which is still compatible with the established occurrence rate of such companions around main-sequence stars. We find significant RV periodicities between 1.3 and 4.5 days for 14 stars, which are, however, all caused by rotational modulation due to starspots. We also analyse the TESS photometric time series data and find significant periodicities for most of the stars. For 11 stars, the photometric periods are also clearly detected in the RV data. We also derive stellar rotation periods ranging from 1 to 10 days for 91 stars, mostly from TESS data. From the intrinsic activity-related short-term RV jitter, we derive the expected mass-detection thresholds for longer-period companions., Comment: 24 pages, 14 figures, 4 tables; Accepted for publication in A&A

Long term precise radial velocity (RV) monitoring of the nearby star HD206893, as well as anomalies in the system proper motion, have suggested the presence of an additional, inner companion in the system. Here we describe the results of a multi-epoch search for the companion responsible for this RV drift and proper motion anomaly using the VLTI/GRAVITY instrument. Utilizing information from ongoing precision RV measurements with the HARPS spectrograph, as well as Gaia host star astrometry, we report a high significance detection of the companion HD206893c over three epochs, with clear evidence for Keplerian orbital motion. Our astrometry with $\sim$50-100 $\mu$arcsec precision afforded by GRAVITY allows us to derive a dynamical mass of 12.7$^{+1.2}_{-1.0}$ M$_{\rm Jup}$ and an orbital separation of 3.53$^{+0.08}_{-0.06}$ au for HD206893c. Our fits to the orbits of both companions in the system utilize both Gaia astrometry and RVs to also provide a precise dynamical estimate of the previously uncertain mass of the B component, and therefore derive an age of $155\pm15$ Myr. We find that theoretical atmospheric/evolutionary models incorporating deuterium burning for HD206893c, parameterized by cloudy atmospheres provide a good simultaneous fit to the luminosity of both HD206893B and c. In addition to utilizing long-term RV information, this effort is an early example of a direct imaging discovery of a bona fide exoplanet that was guided in part with Gaia astrometry. Utilizing Gaia astrometry is expected to be one of the primary techniques going forward to identify and characterize additional directly imaged planets. Lastly, this discovery is another example of the power of optical interferometry to directly detect and characterize extrasolar planets where they form at ice-line orbital separations of 2-4\,au., Comment: Accepted to A&A

A deep (~70%) and extended (~150 days) eclipse was seen towards the young multiple stellar system V773 Tau in 2010. We interpret it as due to the passage of a circumbinary disk around the B components moving in front of the A components. Our aim is to characterise the orientation and structure of the disk, to refine the orbits of the subcomponents, and to predict when the next eclipse will occur. We combine the photometry from several ground based surveys, construct a model for the light curve of the eclipse, and use high angular resolution imaging to refine the orbits of the three components of the system, A, B and C. Frequency analysis of the light curves, including from the TESS satellite, enables characterisation of the rotational periods of the Aa and Ab stars. A toy model of the circumbinary disk shows that it extends out to approximately 5 au around the B binary and has an inclination of 73 degrees with respect to the orbital plane of AB, where the lower bound of the radius of the disk is constrained by the geometry of the AB orbit and the upper bound is set by the stability of the disk. We identify several frequencies in the photometric data that we attribute to rotational modulation of the Aa and Ab stellar companions. We produce the first determination of the orbit of the more distant C component around the AB system and limit its inclination to 93 degrees. The high inclination and large diameter of the disk, together with the match from theory suggest that B is an almost equal mass, moderately eccentric binary. We identify the rotational periods of the Aa and Ab stars, identify a third frequency in the light curve that we attribute to the orbital period of the stars in the B binary. We predict that the next eclipse will be around 2037, during which both detailed photometric and spectroscopic monitoring will characterise the disk in greater detail., Comment: 13 pages, 15 figures, 5 tables, A&A in press. All data and reduction scripts available at https://github.com/mkenworthy/V773TauBdisk

Contains fulltext : 239757.pdf (Publisher’s version ) (Closed access)

Background: The COVID-19 pandemic has forced rapid system-wide changes to be implemented within cancer care at an alarming pace. Clinical trials are a key element of comprehensive cancer care. Ensuring the continuing safe conduct of cancer clinical trials in the context of a pandemic is challenging. Method(s): We aimed to describe the COVID-19 pandemic response of a Cancer Care Clinical Research Unit (CRU) of a tertiary hospital in Queensland, Australia. We used a mixed methods approach for this case study. Emailed directives from CRU managers to all CRU staff sharing were qualitatively analysed and mapped against our unit activities over longitudinal time points. Data from patient recruitment and protocol deviations were analysed using descriptive statistics. Result(s): Mapping activity from 11 March to 30 September 2020 revealed rapid change during the first 2 weeks. Four key strategies to accommodate change were identified: supporting patients and families, introduction of telehealth, accessing investigational product, and social distancing. Early in the pandemic we recognised that our core key stakeholders were integral to our response. When compared to the previous 12 months, our recruitment numbers dropped markedly in early phases of the response but recovered over time, as we accommodated internal and external impacts. Conclusion(s): Our experience of agility as a necessity, adapting to support patients, and managing both clinical research activity and sponsors during the height of the pandemic response is presented here in order to inform future disaster response planning by clinical trial organisations.Copyright © 2021 John Wiley & Sons Australia, Ltd

Abridged: Direct imaging has made significant progress over the past decade leading to the detection of several giant planets. Observing strategies and data rates vary from instrument to instrument and wavelength, and can result in tens of thousands of images to be combined. We here present a new approach, tailored for VLT/NaCo observations performed with the Annular Groove Phase Mask (AGPM) coronagraph at $L'$ filter. Our pipeline aims at improving the post-processing of the observations on two fronts: identifying the location of the star behind the AGPM to better align the science frames and performing frame selection. Our method relies on finding the position of the AGPM in the sky frame observations, and correlate it with the circular aperture of the coronagraphic mask. This relationship allows us to retrieve the location of the AGPM in the science frames, in turn allowing us to estimate the position of the star. In the process we also gather additional information useful for our frame selection approach. We tested our pipeline on several targets, and find that we improve the S/N of companions around $\beta$ Pictoris and R CrA by $24\pm3$ \% and $117\pm11$ \% respectively, compared to other state-of-the-art reductions. The astrometry of the point sources is slightly different but remains compatible within $3\sigma$ compared to published values. Finally, we find that even for NaCo observations with tens of thousands of frames, frame selection yields just marginal improvement for point sources but may improve the final images for objects with extended emission such as disks. We proposed a novel approach to identify the location of the star behind a coronagraph even when it cannot easily be determined by other methods, leading to better S/N for nearby point sources, and led a thorough study on the importance of frame selection, concluding that the improvements are marginal in most case., Comment: Accepted for publication in A&A, November 2021

HD 98800 is a young ($\sim10$ Myr old) and nearby ($\sim45$ pc) quadruple system, composed of two spectroscopic binaries orbiting around each other (AaAb and BaBb), with a gas-rich disk in polar configuration around BaBb. While the orbital parameters of BaBb and AB are relatively well constrained, this is not the case for AaAb. A full characterisation of this quadruple system can provide insights on the formation of such a complex system. The goal of this work is to determine the orbit of the AaAb subsystem and refine the orbital solution of BaBb using multi-epoch interferometric observations with the VLTI/PIONIER and radial velocities. The PIONIER observations provide relative astrometric positions and flux ratios for both AaAa and BaBb subsystems. Combining the astrometric points with radial velocity measurements, we determine the orbital parameters of both subsystems. We refined the orbital solution of BaBb and derived, for the first time, the full orbital solution of AaAb. We confirmed the polar configuration of the circumbinary disk around BaBb. From our solutions, we also inferred the dynamical masses of AaAb ($M_{Aa} = 0.93 \pm 0.09$ and $M_{Ab} = 0.29 \pm 0.02$ M$_{\odot}$). We also revisited the parameters of the AB outer orbit. Using the N-body simulation, we show that the system should be dynamically stable over thousands of orbital periods and that it made preliminary predictions for the transit of the disk in front of AaAb which is estimated to start around 2026. We discuss the lack of a disk around AaAb, which can be explained by the larger X-ray luminosity of AaAb, promoting faster photo-evaporation of the disk. High-resolution infrared spectroscopic observations would provide radial velocities of Aa and Ab (blended lines in contemporary observations), which would allow us to calculate the dynamical masses of Aa and Ab independently of the parallax of BaBb., Comment: Accepted for publication in Astronomy \& Astrophysiscs journal (01/09/2021)

In this era of spatially resolved observations of planet forming disks with ALMA and large ground-based telescopes such as the VLT, Keck and Subaru, we still lack statistically relevant information on the quantity and composition of the material that is building the planets, such as the total disk gas mass, the ice content of dust, and the state of water in planetesimals. SPICA is an infrared space mission concept developed jointly by JAXA and ESA to address these questions. The key unique capabilities of SPICA that enable this research are (1) the wide spectral coverage 10-220 micron, (2) the high line detection sensitivity of (1-2) 10-19 W m-2 with R~2000-5000 in the far-IR (SAFARI) and 10-20 W m-2 with R~29000 in the mid-IR (SMI, spectrally resolving line profiles), (3) the high far-IR continuum sensitivity of 0.45 mJy (SAFARI), and (4) the observing efficiency for point source surveys. This paper details how mid- to far-IR infrared spectra will be unique in measuring the gas masses and water/ice content of disks and how these quantities evolve during the planet forming period. These observations will clarify the crucial transition when disks exhaust their primordial gas and further planet formation requires secondary gas produced from planetesimals. The high spectral resolution mid-IR is also unique for determining the location of the snowline dividing the rocky and icy mass reservoirs within the disk and how the divide evolves during the build-up of planetary systems. Infrared spectroscopy (mid- to far-IR) of key solid state bands is crucial for assessing whether extensive radial mixing, which is part of our Solar System history, is a general process occurring in most planetary systems and whether extrasolar planetesimals are similar to our Solar System comets/asteroids. ... (abbreviated), Comment: accepted for publication in PASA

We present \textit{ALMA} 1.3 mm and 0.86 mm observations of the nearby (17.34 pc) F9V star q1 Eri (HD 10647, HR 506). This system, with age ${\sim}1.4$ Gyr, hosts a ${\sim}2$ au radial velocity planet and a debris disc with the highest fractional luminosity of the closest 300 FGK type stars. The \textit{ALMA} images, with resolution ${\sim}0.5''$, reveal a broad (34{-}134 au) belt of millimeter emission inclined by $76.7{\pm}1.0$ degrees with maximum brightness at $81.6{\pm}0.5$ au. The images reveal an asymmetry, with higher flux near the southwest ansa, which is also closer to the star. Scattered light observed with the Hubble Space Telescope is also asymmetric, being more radially extended to the northeast. We fit the millimeter emission with parametric models and place constraints on the disc morphology, radius, width, dust mass, and scale height. We find the southwest ansa asymmetry is best fitted by an extended clump on the inner edge of the disc, consistent with perturbations from a planet with mass $8 M_{\oplus} {-} 11 M_{\rm Jup}$ at ${\sim}60$ au that may have migrated outwards, similar to Neptune in our Solar System. If the measured vertical aspect ratio of $h{=}0.04{\pm}0.01$ is due to dynamical interactions in the disc, then this requires perturbers with sizes ${>}1200$ km. We find tentative evidence for an 0.86 mm excess within 10 au, $70{\pm}22\, \mu$Jy, that may be due to an inner planetesimal belt. We find no evidence for CO gas, but set an upper bound on the CO gas mass of $4{\times}10^{-6}$ M$_{\oplus}$ ($3\,\sigma$), consistent with cometary abundances in the Solar System., Comment: Accepted for publication in MNRAS. Paper: 21 pages, appendix: 4 pages. 16 figures

(abridged) Context. The origin of hot exozodiacal dust and its connection with outer dust reservoirs remains unclear. Aims. We aim to explore the possible connection between hot exozodiacal dust and warm dust reservoirs (> 100 K) in asteroid belts. Methods. We use precision near-infrared interferometry with VLTI/PIONIER to search for resolved emission at H band around a selected sample of nearby stars. Results. Our observations reveal the presence of resolved near-infrared emission around 17 out of 52 stars, four of which are shown to be due to a previously unknown stellar companion. The 13 other H-band excesses are thought to originate from the thermal emission of hot dust grains. Taking into account earlier PIONIER observations, and after reevaluating the warm dust content of all our PIONIER targets through spectral energy distribution modeling, we find a detection rate of 17.1(+8.1)(-4.6)% for H-band excess around main sequence stars hosting warm dust belts, which is statistically compatible with the occurrence rate of 14.6(+4.3)(-2.8)% found around stars showing no signs of warm dust. After correcting for the sensitivity loss due to partly unresolved hot disks, under the assumption that they are arranged in a thin ring around their sublimation radius, we however find tentative evidence at the 3{\sigma} level that H-band excesses around stars with outer dust reservoirs (warm or cold) could be statistically larger than H-band excesses around stars with no detectable outer dust. Conclusions. Our observations do not suggest a direct connection between warm and hot dust populations, at the sensitivity level of the considered instruments, although they bring to light a possible correlation between the level of H-band excesses and the presence of outer dust reservoirs in general., Comment: Accepted for publication in A&A

Introduction Sars-CoV-2 is a novel coronavirus responsible for COVID-19 officially declared pandemic in March 2020. Health systems worldwide responded with swift changes to increase workflow capacity while protecting the vulnerable, including those with cancer. This led to unprecedented and rapid restructuring of health service provision. Published data from the 2003 SARS pandemic focuses on medical and nursing staff, overlooking other departmental employees such as administration officers or food service workers. Our protocol aims to document directives and adjustments communicated to staff in two cancer care departments and correlate this with measures of distress and perceived preparedness across the spectrum of all staff involved in cancer care. Methods and analysis We use a semiqualitative approach comprising weekly diarising of events and simultaneous staff surveys. Principal investigators will document changes at a metropolitan quaternary cancer centre and a regional cancer centre. Communications, directives and changes will be diarised in real time in four executional domains. Simultaneously, prospective voluntary self-administered online surveys will be conducted at regular intervals by staff. The survey assesses the perceived institutional preparedness and personal well-being, with a combination of Likert scaled and open response questions. A semiquantitative self-assessment of distress adapted from National Comprehensive Cancer Network distress thermometer is incorporated. Additionally, open-text personal reflections on themes including difficult decisions will be invited. Survey participants will be drawn from various work areas of the cancer care departments: administrative staff, health professionals, for example, allied health, ancillary workers, nursing and medical. Ethics and dissemination The study has been reviewed and approved by the Human Research Ethics Committee (LNR/2020/QRBW/62982). Published literature on domains of distress neglects catego

Background: The COVID-19 pandemic has forced rapid system-wide changes to be implemented within cancer care at an alarming pace. Clinical trials are a key element of comprehensive cancer care. Ensuring the continuing safe conduct of cancer clinical trials in the context of a pandemic is challenging. Method(s): We aimed to describe the COVID-19 pandemic response of a Cancer Care Clinical Research Unit (CRU) of a tertiary hospital in Queensland, Australia. We used a mixed methods approach for this case study. Emailed directives from CRU managers to all CRU staff sharing were qualitatively analysed and mapped against our unit activities over longitudinal time points. Data from patient recruitment and protocol deviations were analysed using descriptive statistics. Result(s): Mapping activity from 11 March to 30 September 2020 revealed rapid change during the first 2 weeks. Four key strategies to accommodate change were identified: supporting patients and families, introduction of telehealth, accessing investigational product, and social distancing. Early in the pandemic we recognised that our core key stakeholders were integral to our response. When compared to the previous 12 months, our recruitment numbers dropped markedly in early phases of the response but recovered over time, as we accommodated internal and external impacts. Conclusion(s): Our experience of agility as a necessity, adapting to support patients, and managing both clinical research activity and sponsors during the height of the pandemic response is presented here in order to inform future disaster response planning by clinical trial organisations.Copyright © 2021 John Wiley & Sons Australia, Ltd

Changes to donor availability, collection center capacity, and travel restrictions during the early phase of the COVID-19 pandemic led to routine cryopreservation of most unrelated donor products for hematopoietic transplantation prior to the recipient commencing the conditioning regimen. We investigated the effect of this change on unrelated donor product quality and clinical outcomes. Product information was requested from transplantation centers in Australia and New Zealand and clinical outcome data from the Australasian Bone Marrow Transplant Recipient Registry (ABMTRR). In total, 191 products were collected between April 1, 2021, and September 30, 2021, and most (74%) were from international collection centers. Median post-thaw CD34 recovery was 78% (range 25% to 176%) and median post-thaw CD34 viability was 87% (range 34% to 112%). Median time to neutrophil recovery was 17 days (interquartile range 10 to 24 days), and graft failure occurred in 6 patients (4%). These clinical outcomes were similar to those of "fresh" unrelated donor transplants reported to the ABMTRR in 2019. However, recipient transplantation centers reported problems with 29% of products in the form of damage during transit, low cell dose, inadequate labeling, missing representative samples, or missing documentation. These problems were critical in 7 cases (4%). At last follow-up, 22 products (12%) had not been infused. Routine cryopreservation of unrelated donor hemopoietic progenitor cell products has enabled safe continuation of allogeneic transplant services during the COVID-19 pandemic. However, practices for product tracing, documentation, and transportation can be optimized, and measures to reduce the incidence of unused unrelated donor product are required.

Australia and New Zealand have achieved excellent community control of COVID-19 infection. In light of the imminent COVID-19 vaccination roll out in both countries, representatives of all adult and paediatric allogeneic bone marrow transplant and cellular therapy (TCT) centres as well as representatives from autologous transplant only centres in Australia and New Zealand collaborated with infectious diseases specialists with expertise in TCT on this consensus position statement regarding COVID-19 vaccination in TCT patients in Australia and New Zealand. It is our recommendation that TCT patients, should have expedited access to high-efficacy COVID-19 vaccines given that these patients are at high risk of morbidity and mortality from COVID-19 infection. We also recommend prioritising vaccination of TCT healthcare workers and household members of TCT patients. Vaccination should not replace other public health measures in TCT patients given the effectiveness of COVID-19 vaccination in TCT patients is unknown. Furthermore, given the limited available data, prospective collection of safety and efficacy data of COVID-19 vaccination in this patient group is a priority.

BACKGROUND: In the absence of a method to culture Plasmodium vivax, the only way to source parasites is ex vivo. This hampers many aspects of P. vivax research. This study aimed to assess the safety of apheresis, a method for selective removal of specific components of blood as a means of extracting and concentrating P. vivax parasites. METHODS: An iterative approach was employed across four non-immune healthy human subjects in single subject cohorts. All four subjects were inoculated with ~ 564 blood stage P. vivax (HMP013-Pv) and subjected to apheresis 10 to 11 days later. Blood samples collected during apheresis (haematocrit layers 0.5% to 11%) were tested for the presence and concentration of P. vivax by microscopy, flow cytometry, 18S rDNA qPCR for total parasites, and pvs25 qRT-PCR for female gametocyte transcripts. Safety was determined by monitoring adverse events. Malaria transmission to mosquitoes was assessed by membrane feeding assays. RESULTS: There were no serious adverse events and no significant safety concerns. Apheresis concentrated asexual parasites by up to 4.9-fold (range: 0.9-4.9-fold) and gametocytes by up to 1.45-fold (range: 0.38-1.45-fold) compared to pre-apheresis densities. No single haematocrit layer contained > 40% of all the recovered P. vivax asexual parasites. Ex vivo concentration of parasites by Percoll gradient centrifugation of whole blood achieved greater concentration of gametocytes than apheresis. Mosquito transmission was enhanced by up to fivefold in a single apheresis sample compared to pre-apheresis. CONCLUSION: The modest level of parasite concentration suggests that the use of apheresis may not be an ideal method for harvesting P. vivax. Trial Registration Australia New Zealand Clinical Trials Registry (ANZCTR) Trial ID: ACTRN12617001502325 registered on 19th October 2017. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=373812.

In this era of spatially resolved observations of planet-forming disks with Atacama Large Millimeter Array (ALMA) and large groundbased telescopes such as the Very Large Telescope (VLT), Keck, and Subaru, we still lack statistically relevant information on the quantity and composition of the material that is building the planets, such as the total disk gas mass, the ice content of dust, and the state of water in planetesimals. SPace Infrared telescope for Cosmology and Astrophysics (SPICA) is an infrared space mission concept developed jointly by Japan Aerospace Exploration Agency (JAXA) and European Space Agency (ESA) to address these questions. The key unique capabilities of SPICA that enable this research are (1) the wide spectral coverage 10-220 mu m, (2) the high line detection sensitivity of (1-2) x10(-19)Wm(-2) with R similar to 2 000-5 000 in the far-IR (SAFARI), and 10-20Wm(-2) with R similar to 29 000 in themid-IR (SPICA Mid-infrared Instrument (SMI), spectrally resolving line profiles), (3) the high far-IR continuum sensitivity of 0.45mJy (SAFARI), and (4) the observing efficiency for point source surveys. This paper details how mid- to far-IR infrared spectra will be unique in measuring the gas masses and water/ice content of disks and how these quantities evolve during the planet-forming period. These observations will clarify the crucial transition when disks exhaust their primordial gas and further planet formation requires secondary gas produced from planetesimals. The high spectral resolution mid-IR is also unique for determining the location of the snowline dividing the rocky and icy mass reservoirs within the disk and how the divide evolves during the build-up of planetary systems. Infrared spectroscopy (mid- to far-IR) of key solid-state bands is crucial for assessing whether extensive radial mixing, which is part of our Solar System history, is a general process occurring in most planetary systems and whether extrasolar planetesimals are similar

Contains fulltext : 239757.pdf (Publisher’s version ) (Closed access)

Contains fulltext : 239757.pdf (Publisher’s version ) (Closed access)

Deep learning algorithms such as Convolutional Neural Networks (CNNs) are currently used to solve a range of robotics and computer vision problems. These networks typically estimate the desired representation in a single forward pass and must therefore learn to converge from a wide range of initial conditions to a precise result. This is challenging, and has led to increased interest in the development of separate refinement modules which learn to improve a given initial estimate, thus reducing the required search space. Such modules are usually developed ad-hoc for each given application, often requiring significant engineering investment. In this work we propose a generic innovation-based CNN. Our CNN is implemented along with a stochastic gradient descent (SGD) algorithm to iteratively refine a given initial estimate. The proposed approach provides a general framework for the development of refinement modules applicable to a wide range of robotics problems. We apply this framework to object pose estimation and depth estimation and demonstrate significant improvement over the initial estimates, in the range of 4.2 - 8.1%, for both applications.

Abridged: Direct imaging has made significant progress over the past decade leading to the detection of several giant planets. Observing strategies and data rates vary from instrument to instrument and wavelength, and can result in tens of thousands of images to be combined. We here present a new approach, tailored for VLT/NaCo observations performed with the Annular Groove Phase Mask (AGPM) coronagraph at $L'$ filter. Our pipeline aims at improving the post-processing of the observations on two fronts: identifying the location of the star behind the AGPM to better align the science frames and performing frame selection. Our method relies on finding the position of the AGPM in the sky frame observations, and correlate it with the circular aperture of the coronagraphic mask. This relationship allows us to retrieve the location of the AGPM in the science frames, in turn allowing us to estimate the position of the star. In the process we also gather additional information useful for our frame selection approach. We tested our pipeline on several targets, and find that we improve the S/N of companions around $\beta$ Pictoris and R CrA by $24\pm3$ \% and $117\pm11$ \% respectively, compared to other state-of-the-art reductions. The astrometry of the point sources is slightly different but remains compatible within $3\sigma$ compared to published values. Finally, we find that even for NaCo observations with tens of thousands of frames, frame selection yields just marginal improvement for point sources but may improve the final images for objects with extended emission such as disks. We proposed a novel approach to identify the location of the star behind a coronagraph even when it cannot easily be determined by other methods, leading to better S/N for nearby point sources, and led a thorough study on the importance of frame selection, concluding that the improvements are marginal in most case., Comment: Accepted for publication in A&A, November 2021

HD 98800 is a young ($\sim10$ Myr old) and nearby ($\sim45$ pc) quadruple system, composed of two spectroscopic binaries orbiting around each other (AaAb and BaBb), with a gas-rich disk in polar configuration around BaBb. While the orbital parameters of BaBb and AB are relatively well constrained, this is not the case for AaAb. A full characterisation of this quadruple system can provide insights on the formation of such a complex system. The goal of this work is to determine the orbit of the AaAb subsystem and refine the orbital solution of BaBb using multi-epoch interferometric observations with the VLTI/PIONIER and radial velocities. The PIONIER observations provide relative astrometric positions and flux ratios for both AaAa and BaBb subsystems. Combining the astrometric points with radial velocity measurements, we determine the orbital parameters of both subsystems. We refined the orbital solution of BaBb and derived, for the first time, the full orbital solution of AaAb. We confirmed the polar configuration of the circumbinary disk around BaBb. From our solutions, we also inferred the dynamical masses of AaAb ($M_{Aa} = 0.93 \pm 0.09$ and $M_{Ab} = 0.29 \pm 0.02$ M$_{\odot}$). We also revisited the parameters of the AB outer orbit. Using the N-body simulation, we show that the system should be dynamically stable over thousands of orbital periods and that it made preliminary predictions for the transit of the disk in front of AaAb which is estimated to start around 2026. We discuss the lack of a disk around AaAb, which can be explained by the larger X-ray luminosity of AaAb, promoting faster photo-evaporation of the disk. High-resolution infrared spectroscopic observations would provide radial velocities of Aa and Ab (blended lines in contemporary observations), which would allow us to calculate the dynamical masses of Aa and Ab independently of the parallax of BaBb., Comment: Accepted for publication in Astronomy \& Astrophysiscs journal (01/09/2021)

In this era of spatially resolved observations of planet forming disks with ALMA and large ground-based telescopes such as the VLT, Keck and Subaru, we still lack statistically relevant information on the quantity and composition of the material that is building the planets, such as the total disk gas mass, the ice content of dust, and the state of water in planetesimals. SPICA is an infrared space mission concept developed jointly by JAXA and ESA to address these questions. The key unique capabilities of SPICA that enable this research are (1) the wide spectral coverage 10-220 micron, (2) the high line detection sensitivity of (1-2) 10-19 W m-2 with R~2000-5000 in the far-IR (SAFARI) and 10-20 W m-2 with R~29000 in the mid-IR (SMI, spectrally resolving line profiles), (3) the high far-IR continuum sensitivity of 0.45 mJy (SAFARI), and (4) the observing efficiency for point source surveys. This paper details how mid- to far-IR infrared spectra will be unique in measuring the gas masses and water/ice content of disks and how these quantities evolve during the planet forming period. These observations will clarify the crucial transition when disks exhaust their primordial gas and further planet formation requires secondary gas produced from planetesimals. The high spectral resolution mid-IR is also unique for determining the location of the snowline dividing the rocky and icy mass reservoirs within the disk and how the divide evolves during the build-up of planetary systems. Infrared spectroscopy (mid- to far-IR) of key solid state bands is crucial for assessing whether extensive radial mixing, which is part of our Solar System history, is a general process occurring in most planetary systems and whether extrasolar planetesimals are similar to our Solar System comets/asteroids. ... (abbreviated), Comment: accepted for publication in PASA

We present \textit{ALMA} 1.3 mm and 0.86 mm observations of the nearby (17.34 pc) F9V star q1 Eri (HD 10647, HR 506). This system, with age ${\sim}1.4$ Gyr, hosts a ${\sim}2$ au radial velocity planet and a debris disc with the highest fractional luminosity of the closest 300 FGK type stars. The \textit{ALMA} images, with resolution ${\sim}0.5''$, reveal a broad (34{-}134 au) belt of millimeter emission inclined by $76.7{\pm}1.0$ degrees with maximum brightness at $81.6{\pm}0.5$ au. The images reveal an asymmetry, with higher flux near the southwest ansa, which is also closer to the star. Scattered light observed with the Hubble Space Telescope is also asymmetric, being more radially extended to the northeast. We fit the millimeter emission with parametric models and place constraints on the disc morphology, radius, width, dust mass, and scale height. We find the southwest ansa asymmetry is best fitted by an extended clump on the inner edge of the disc, consistent with perturbations from a planet with mass $8 M_{\oplus} {-} 11 M_{\rm Jup}$ at ${\sim}60$ au that may have migrated outwards, similar to Neptune in our Solar System. If the measured vertical aspect ratio of $h{=}0.04{\pm}0.01$ is due to dynamical interactions in the disc, then this requires perturbers with sizes ${>}1200$ km. We find tentative evidence for an 0.86 mm excess within 10 au, $70{\pm}22\, \mu$Jy, that may be due to an inner planetesimal belt. We find no evidence for CO gas, but set an upper bound on the CO gas mass of $4{\times}10^{-6}$ M$_{\oplus}$ ($3\,\sigma$), consistent with cometary abundances in the Solar System., Comment: Accepted for publication in MNRAS. Paper: 21 pages, appendix: 4 pages. 16 figures

(abridged) Context. The origin of hot exozodiacal dust and its connection with outer dust reservoirs remains unclear. Aims. We aim to explore the possible connection between hot exozodiacal dust and warm dust reservoirs (> 100 K) in asteroid belts. Methods. We use precision near-infrared interferometry with VLTI/PIONIER to search for resolved emission at H band around a selected sample of nearby stars. Results. Our observations reveal the presence of resolved near-infrared emission around 17 out of 52 stars, four of which are shown to be due to a previously unknown stellar companion. The 13 other H-band excesses are thought to originate from the thermal emission of hot dust grains. Taking into account earlier PIONIER observations, and after reevaluating the warm dust content of all our PIONIER targets through spectral energy distribution modeling, we find a detection rate of 17.1(+8.1)(-4.6)% for H-band excess around main sequence stars hosting warm dust belts, which is statistically compatible with the occurrence rate of 14.6(+4.3)(-2.8)% found around stars showing no signs of warm dust. After correcting for the sensitivity loss due to partly unresolved hot disks, under the assumption that they are arranged in a thin ring around their sublimation radius, we however find tentative evidence at the 3{\sigma} level that H-band excesses around stars with outer dust reservoirs (warm or cold) could be statistically larger than H-band excesses around stars with no detectable outer dust. Conclusions. Our observations do not suggest a direct connection between warm and hot dust populations, at the sensitivity level of the considered instruments, although they bring to light a possible correlation between the level of H-band excesses and the presence of outer dust reservoirs in general., Comment: Accepted for publication in A&A

The young (50-400 Myr) A3V star $\beta$ Leo is a primary target to study the formation history and evolution of extrasolar planetary systems as one of the few stars with known hot ($\sim$1600$^\circ$K), warm ($\sim$600$^\circ$K), and cold ($\sim$120$^\circ$K) dust belt components. In this paper, we present deep mid-infrared measurements of the warm dust brightness obtained with the Large Binocular Telescope Interferometer (LBTI) as part of its exozodiacal dust survey (HOSTS). The measured excess is 0.47\%$\pm$0.050\% within the central 1.5 au, rising to 0.81\%$\pm$0.026\% within 4.5 au, outside the habitable zone of $\beta$~Leo. This dust level is 50 $\pm$ 10 times greater than in the solar system's zodiacal cloud. Poynting-Robertson drag on the cold dust detected by Spitzer and Herschel under-predicts the dust present in the habitable zone of $\beta$~Leo, suggesting an additional delivery mechanism (e.g.,~comets) or an additional belt at $\sim$5.5 au. A model of these dust components is provided which implies the absence of planets more than a few Saturn masses between $\sim$5 au and the outer belt at $\sim$40 au. We also observationally constrain giant planets with the LBTI imaging channel at 3.8~$\mu$m wavelength. Assuming an age of 50 Myr, any planet in the system between approximately 5 au to 50 au must be less than a few Jupiter masses, consistent with our dust model. Taken together, these observations showcase the deep contrasts and detection capabilities attainable by the LBTI for both warm exozodiacal dust and giant exoplanets in or near the habitable zone of nearby stars., Comment: 11 pages, 9 figures, accepted for publication in Astronomical Journal

Photometric monitoring of Beta Pictoris in 1981 showed anomalous fluctuations of up to 4% over several days, consistent with foreground material transiting the stellar disk. The subsequent discovery of the gas giant planet Beta Pictoris b and the predicted transit of its Hill sphere to within 0.1 au projected distance of the planet provided an opportunity to search for the transit of a circumplanetary disk in this $21\pm 4$ Myr-old planetary system. Continuous broadband photometric monitoring of Beta Pictoris requires ground-based observatories at multiple longitudes to provide redundancy and to provide triggers for rapid spectroscopic followup. These observatories include the dedicated Beta Pictoris monitoring observatory bRing at Sutherland and Siding Springs, the ASTEP400 telescope at Concordia, and observations from the space observatories BRITE and Hubble Space Telescope. We search the combined light curves for evidence of short period transient events caused by rings and for longer term photometric variability due to diffuse circumplanetary material. We find no photometric event that matches with the event seen in November 1981, and there is no systematic photometric dimming of the star as a function of the Hill sphere radius. We conclude that the 1981 event was not caused by the transit of a circumplanetary disk around Beta Pictoris b. The upper limit on the long term variability of Beta Pictoris places an upper limit of $1.8\times 10^{22}$ g of dust within the Hill sphere. Circumplanetary material is either condensed into a non-transiting disk, is condensed into a disk with moons that has a small obliquity, or is below our detection threshold. This is the first time that a dedicated international campaign has mapped the Hill sphere transit of a gas giant extrasolar planet at 10 au., Comment: 12 pages, 9 figures, 1 table, accepted for publication in A&A. Reduced data and reduction scripts on GitHub at https://github.com/mkenworthy/beta_pic_b_hill_sphere_transit

In this era of spatially resolved observations of planet-forming disks with Atacama Large Millimeter Array (ALMA) and large groundbased telescopes such as the Very Large Telescope (VLT), Keck, and Subaru, we still lack statistically relevant information on the quantity and composition of the material that is building the planets, such as the total disk gas mass, the ice content of dust, and the state of water in planetesimals. SPace Infrared telescope for Cosmology and Astrophysics (SPICA) is an infrared space mission concept developed jointly by Japan Aerospace Exploration Agency (JAXA) and European Space Agency (ESA) to address these questions. The key unique capabilities of SPICA that enable this research are (1) the wide spectral coverage 10-220 mu m, (2) the high line detection sensitivity of (1-2) x10(-19)Wm(-2) with R similar to 2 000-5 000 in the far-IR (SAFARI), and 10-20Wm(-2) with R similar to 29 000 in themid-IR (SPICA Mid-infrared Instrument (SMI), spectrally resolving line profiles), (3) the high far-IR continuum sensitivity of 0.45mJy (SAFARI), and (4) the observing efficiency for point source surveys. This paper details how mid- to far-IR infrared spectra will be unique in measuring the gas masses and water/ice content of disks and how these quantities evolve during the planet-forming period. These observations will clarify the crucial transition when disks exhaust their primordial gas and further planet formation requires secondary gas produced from planetesimals. The high spectral resolution mid-IR is also unique for determining the location of the snowline dividing the rocky and icy mass reservoirs within the disk and how the divide evolves during the build-up of planetary systems. Infrared spectroscopy (mid- to far-IR) of key solid-state bands is crucial for assessing whether extensive radial mixing, which is part of our Solar System history, is a general process occurring in most planetary systems and whether extrasolar planetesimals are simi

Food systems that deliver healthy diets without exceeding the planet’s resources are essential to achieve the worlds’ ambitious development goals. Healthy diets need to be safe, accessible, and affordable for all, including for disadvantaged and nutritionally vulnerable groups such as of smallholder producers, traders, and consumers in low- and middle-income countries. Globally, food systems are experiencing rapid and drastic changes and are failing to fulfil these multiple duties simultaneously. The international community therefore calls for rigorous food systems transformations and policy solutions to support the achievement of healthy diets for all. Most strategies, however, are essentially supply- and market-oriented. Incorporation of a healthy diet perspective in food system transformation is essential to enable food systems to deliver not only on supplying nutritious foods but also on ensuring that consumers have access can afford and desire healthy, sustainable, and culturally acceptable diets. This paper argues that this should be guided by information on diets, dietary trends, consumer motives, and food environment characteristics. Transformational approaches and policies should also take into account the stage of food system development requiring different strategies to ensure healthier diets for consumers. We review current knowledge on drivers of consumer choices at the individual and food environment level with special emphasis on low- and middle income countries, discuss the converging and conflicting objectives that exist among multiple food-system actors, and argue that failure to strengthen synergies and resolve trade-offs may lead to missed opportunities and benefits, or negative unintended consequences in food system outcomes. The paper proposes a menu of promising consumer- and food-environment- oriented policy options to include in the food systems transformation agenda in order to shift LMIC consumer demand towards healthier diets in low- and

PR, IFPRI3; CRP4; ISI; 2 Promoting Healthy Diets and Nutrition for all, A4NH; MTID; PHND, CGIAR Research Program on Agriculture for Nutrition and Health (A4NH), Food systems that deliver healthy diets without exceeding the planet’s resources are essential to achieve the worlds’ ambitious development goals. Healthy diets need to be safe, accessible, and affordable for all, including for disadvantaged and nutritionally vulnerable groups such as of smallholder producers, traders, and consumers in low- and middle-income countries. Globally, food systems are experiencing rapid and drastic changes and are failing to fulfil these multiple duties simultaneously. The international community therefore calls for rigorous food systems transformations and policy solutions to support the achievement of healthy diets for all. Most strategies, however, are essentially supply- and market-oriented. Incorporation of a healthy diet perspective in food system transformation is essential to enable food systems to deliver not only on supplying nutritious foods but also on ensuring that consumers have access can afford and desire healthy, sustainable, and culturally acceptable diets. This paper argues that this should be guided by information on diets, dietary trends, consumer motives, and food environment characteristics. Transformational approaches and policies should also take into account the stage of food system development requiring different strategies to ensure healthier diets for consumers. We review current knowledge on drivers of consumer choices at the individual and food environment level with special emphasis on low- and middle income countries, discuss the converging and conflicting objectives that exist among multiple food-system actors, and argue that failure to strengthen synergies and resolve trade-offs may lead to missed opportunities and benefits, or negative unintended consequences in food system outcomes. The paper proposes a menu of promising consumer- and food-environment- oriented policy options to include in the food systems transformation agenda in order to shift LMIC consumer demand towards healthier diets in low- and

info:eu-repo/semantics/published

Context. The occurrence rate of long-period (a greater than or similar to 50 au) giant planets around young stars is highly uncertain since it is not only governed by the protoplanetary disc structure and planet formation process, but also reflects both dynamical re-structuring processes after planet formation as well as possible capture of planets not formed in situ. Direct imaging is currently the only feasible method to detect such wide-orbit planets and constrain their occurrence rate.Aims. We aim to detect and characterise wide-orbit giant planets during and shortly after their formation phase within protoplanetary and debris discs around nearby young stars.Methods. We carry out a large L-band high-contrast direct imaging survey for giant planets around 200 young stars with protoplanetary or debris discs using the NACO instrument at the ESO Very Large Telescope on Cerro Paranal in Chile. We use very deep angular differential imaging observations with typically >60 degrees field rotation, and employ a vector vortex coronagraph where feasible to achieve the best possible point source sensitivity down to an inner working angle of about 100 mas. This paper introduces the NACO Imaging Survey for Planets around Young stars (NACO-ISPY), its goals and strategy, the target list, and data reduction scheme, and presents preliminary results from the first 2.5 survey years.Results. We achieve a mean 5 sigma contrast of Delta L ' = 6.4 +/- 0.1 mag at 150 mas and a background limit of L ' (bg) = 16.5 +/- 0.2 textual-form L bg ' =16.5 +/- 0.2 mag at 1.' ' 5. Our detection probability is 50% for companions with greater than or similar to 8 M-Jup at semi-major axes of 80-200 au and >13 M-Jup at 30-250 au. It thus compares well to the detection space of other state-of-the-art high-contrast imaging surveys. We have already contributed to the characterisation of two new planets originally discovered by VLT/SPHERE, but we have not yet independently discovered new planets aroun

Extra virgin olive oil (EVOO) is suggested to be cardioprotective, partly due to its high phenolic content. We investigated the effect of extra virgin high polyphenol olive oil (HPOO) versus low polyphenol olive oil (LPOO) on blood pressure (BP) and arterial stiffness in healthy Australian adults. In a double-blind, randomized, controlled cross-over trial, 50 participants (age 38.5 ± 13.9 years, 66% female) were randomized to consume 60 mL/day of either HPOO (360 mg/kg polyphenols) or LPOO (86 mg/kg polyphenols) for three weeks. Following a two-week washout period, participants crossed over to consume the alternate oil. Anthropometric data, peripheral BP, central BP and arterial stiffness were measured at baseline and follow up. No significant differences were observed in the changes from baseline to follow up between the two treatments. However, a significant decrease in peripheral and central systolic BP (SBP) by 2.5 mmHg (95% CI: −4.7 to −0.3) and 2.7 mmHg (95% CI: −4.7 to −0.6), respectively, was observed after HPOO consumption. Neither olive oil changed diastolic BP (DBP) or measures of arterial stiffness. The reductions in SBP after HPOO consumption provide evidence for a potentially widely accessible dietary intervention to prevent cardiovascular disease in a multiethnic population. Longer intervention studies and/or higher doses of EVOO polyphenols are warranted to elucidate the potential effect on DBP and arterial stiffness.

The occurrence rate of long-period giant planets around young stars is highly uncertain since it is not only governed by the protoplanetary disc structure and planet formation process, but also reflects dynamical re-structuring processes after planet formation as well as possible capture of planets not formed in-situ. Direct imaging is currently the only feasible method to detect such wide-orbit planets and constrain their occurrence rate. We carry out a large L'-band high-contrast direct imaging survey for giant planets around young stars with protoplanetary or debris discs using the NACO instrument at the ESO Very Large Telescope on Cerro Paranal in Chile. We use very deep angular differential imaging observations with typically >60 deg field rotation, and employ a vector vortex coronagraph where feasible to achieve the best possible point source sensitivity down to an inner working angle of about 100mas. This paper introduces our NACO Imaging Survey for Planets around Young stars ("NACO-ISPY"), its goals and strategy, the target list, and data reduction scheme, and presents preliminary results from the first 2.5 survey years. We achieve a mean 5 sigma L' contrast of 6.4mag at 150mas and a background limit of 16.5mag at >1.5". Our detection probability is >50\% for companions with 8\,M$_{\rm Jup}$\ at semi-major axes 80-200au. It thus compares well to the detection space of other state-of-the-art high-contrast imaging surveys. We have contributed to the characterisation of two new planets originally discovered by VLT/SPHERE, but we have not yet independently discovered new planets around any of our target stars. We report the discovery of close-in low-mass stellar companions around four young stars and show L'-band scattered light images of the discs around eleven stars, six of which have never been imaged at L'-band before., Comment: 25 pages, 14 figures

Extra virgin olive oil (EVOO) is suggested to be cardioprotective, partly due to its high phenolic content. We investigated the effect of extra virgin high polyphenol olive oil (HPOO) versus low polyphenol olive oil (LPOO) on blood pressure (BP) and arterial stiffness in healthy Australian adults. In a double-blind, randomized, controlled cross-over trial, 50 participants (age 38.5 ± 13.9 years, 66% female) were randomized to consume 60 mL/day of either HPOO (360 mg/kg polyphenols) or LPOO (86 mg/kg polyphenols) for three weeks. Following a two-week washout period, participants crossed over to consume the alternate oil. Anthropometric data, peripheral BP, central BP and arterial stiffness were measured at baseline and follow up. No significant differences were observed in the changes from baseline to follow up between the two treatments. However, a significant decrease in peripheral and central systolic BP (SBP) by 2.5 mmHg (95% CI: −4.7 to −0.3) and 2.7 mmHg (95% CI: −4.7 to −0.6), respectively, was observed after HPOO consumption. Neither olive oil changed diastolic BP (DBP) or measures of arterial stiffness. The reductions in SBP after HPOO consumption provide evidence for a potentially widely accessible dietary intervention to prevent cardiovascular disease in a multiethnic population. Longer intervention studies and/or higher doses of EVOO polyphenols are warranted to elucidate the potential effect on DBP and arterial stiffness.

Extra virgin olive oil (EVOO) is suggested to be cardioprotective, partly due to its high phenolic content. We investigated the effect of extra virgin high polyphenol olive oil (HPOO) versus low polyphenol olive oil (LPOO) on blood pressure (BP) and arterial stiffness in healthy Australian adults. In a double-blind, randomized, controlled cross-over trial, 50 participants (age 38.5 ± 13.9 years, 66% female) were randomized to consume 60 mL/day of either HPOO (360 mg/kg polyphenols) or LPOO (86 mg/kg polyphenols) for three weeks. Following a two-week washout period, participants crossed over to consume the alternate oil. Anthropometric data, peripheral BP, central BP and arterial stiffness were measured at baseline and follow up. No significant differences were observed in the changes from baseline to follow up between the two treatments. However, a significant decrease in peripheral and central systolic BP (SBP) by 2.5 mmHg (95% CI: -4.7 to -0.3) and 2.7 mmHg (95% CI: -4.7 to -0.6), respectively, was observed after HPOO consumption. Neither olive oil changed diastolic BP (DBP) or measures of arterial stiffness. The reductions in SBP after HPOO consumption provide evidence for a potentially widely accessible dietary intervention to prevent cardiovascular disease in a multiethnic population. Longer intervention studies and/or higher doses of EVOO polyphenols are warranted to elucidate the potential effect on DBP and arterial stiffness.

Essay tasks are a widely used form of assessment in higher education. Writing analytics can assist with challenges related to using essay tasks at scale and to identifying different issues in academic integrity. In this paper, we combined two techniques to investigate how students’ writing analytics varied across essay tasks with different cognitive load, considering both their typing behavior (i.e., writing process) and writing style (i.e., writing product). We also examined their relationship across these essay tasks. Findings showed that writing processes change across tasks with different cognitive load: when cognitive load increases, the interword intervals (indicator of planning and/or reviewing processes) increased, the burst length (indicator of translation processes) decreased, and the number of revisions per minute (indicator of reviewing processes) decreased. In contrast to the relation between the writing process and cognitive load, the relation between the writing product and cognitive load was found less clear. The results showed small and mixed effects of the tasks differing in cognitive load on the different writing product metrics. Hence, although the writing product follows from the writing process, the relation between cognitive load and the writing product and process appears to be less straightforward.

BACKGROUND: Previous clinical studies have suggested that high polyphenol extra virgin olive oil (EVOO) provides a superior cardioprotective effect compared to low polyphenol olive oil. However, further studies are required to replicate these results in non-Mediterranean populations. AIM: To investigate the effect of high polyphenol EVOO versus low polyphenol olive oil with known polyphenol composition on markers of cardiovascular disease risk in a healthy non-Mediterranean cohort. METHODS: In a double-blind randomised cross-over trial, the present study will examine the effect of high polyphenol EVOO versus low polyphenol olive oil in 50 healthy participants. Each intervention phase will be 3 weeks long with a 2-week washout period between each phase. Outcomes to be assessed include HDL cholesterol efflux, oxidised LDL, blood lipids, C-reactive protein, arterial stiffness, blood pressure and cognitive function. Dietary intake, physical activity levels and anthropometry will also be collected. DISCUSSION: Because of the rigorous trial design, novel and clinically relevant outcomes, the use of a well-characterised EVOO, and, in contrast to the current literature, the non-Mediterranean study population, the present study will provide a significant contribution to the understanding of the clinical importance of polyphenol intake in the Australian sociocultural context.

Extra virgin olive oil (EVOO) is suggested to be cardioprotective, partly due to its high phenolic content. We investigated the effect of extra virgin high polyphenol olive oil (HPOO) versus low polyphenol olive oil (LPOO) on blood pressure (BP) and arterial stiffness in healthy Australian adults. In a double-blind, randomized, controlled cross-over trial, 50 participants (age 38.5 ± 13.9 years, 66% female) were randomized to consume 60 mL/day of either HPOO (360 mg/kg polyphenols) or LPOO (86 mg/kg polyphenols) for three weeks. Following a two-week washout period, participants crossed over to consume the alternate oil. Anthropometric data, peripheral BP, central BP and arterial stiffness were measured at baseline and follow up. No significant differences were observed in the changes from baseline to follow up between the two treatments. However, a significant decrease in peripheral and central systolic BP (SBP) by 2.5 mmHg (95% CI: −4.7 to −0.3) and 2.7 mmHg (95% CI: −4.7 to −0.6), respectively, was observed after HPOO consumption. Neither olive oil changed diastolic BP (DBP) or measures of arterial stiffness. The reductions in SBP after HPOO consumption provide evidence for a potentially widely accessible dietary intervention to prevent cardiovascular disease in a multiethnic population. Longer intervention studies and/or higher doses of EVOO polyphenols are warranted to elucidate the potential effect on DBP and arterial stiffness.

© 2019, © 2019 Society for Research into Higher Education. With an increase in technology to mediate learning and a shift to more student-centred approaches, open-ended online assignment tasks are becoming more common in higher education. Open-ended tasks offer opportunities for students to develop their own interpretations of the requirements, and online technologies offer greater flexibility and afford new types of interactions with teachers and other students. This paper presents a study of students' task interpretation and self-set goals in the context of five open-ended online assignment tasks. The findings presented in this paper demonstrate the importance of a high-quality task understanding for goal setting and suggest practical implications for task design and support.

We report the first characterisation of the individual discs in the intermediate separation binary systems KK Oph and HD 144668 at millimetre wavelengths. In both systems the circum-primary and the circum-secondary discs are detected in the millimetre continuum emission, but not in $^{13}$CO nor C$^{18}$O lines. Even though the disc structure is only marginally resolved, we find indications of large-scale asymmetries in the outer regions of the primary discs, most likely due to perturbation by the companion. The derived dust masses are firmly above debris disc level for all stars. The primaries have about three times more dust in their discs than the secondaries. In the case of HD 144668 the opacity spectral index of the primary and secondary differ by the large margin of 0.69 which may be a consequence of the secondary disc being more compact. Upper limits on the gas masses imply less than 0.1 M$_{\textrm{jup}}$ in any of these discs, meaning that giant planets can no longer form in them. Considering that there have been no massive gas discs identified to date in intermediate separation binaries (i.e., binaries at a few hundred au separation), this opens space for speculation whether their binarity causes the removal of gas, with tidal interaction truncating the discs and hence shortening the accretion timescale. More systematic studies in this respect are sorely needed., Comment: 12 pages. Accepted for publication in MNRAS

We observed the K7 class III star NO Lup in an ALMA survey of the 1-3 Myr Lupus association and detected circumstellar dust and CO gas. Here we show that the J = 3-2 CO emission is both spectrally and spatially resolved, with a broad velocity width ${\sim}19$kms$^{-1}$ for its resolved size ${\sim}1''$ (${\sim}130$ au). We model the gas emission as a Keplerian disc, finding consistency, but only with a central mass of ${\sim}11M_{\odot}$, which is implausible given its spectral type and X-Shooter spectrum. A good fit to the data can also be found by modelling the CO emission as outflowing gas with a radial velocity ${\sim}22$kms$^{-1}$. We interpret NO Lup's CO emission as the first imaged class III circumstellar disc with outflowing gas. We conclude that the CO is continually replenished, but cannot say if this is from the break-up of icy planetesimals or from the last remnants of the protoplanetary disc. We suggest further work to explore the origin of this CO, and its higher than expected velocity in comparison to photoevaporative models., Comment: 6 pages, 4 figures. Accepted for publication in MNRAS following peer review (this is a pre-copyedited, author-produced PDF version)