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1. The ATI score (age-thrombus burden-index of microcirculatory resistance) determined during primary percutaneous coronary intervention predicts final infarct size in patients with ST-elevation myocardial infarction: A cardiac magnetic resonance validation study

Author

De Maria, Giovanni Luigi, Alkhalil, M, Wolfrum, M, Fahrni, G, Borlotti, A, Gaughran, L, Dawkins, S, Langrish, Jp, Lucking, Aj, Choudhury, Rp, Porto, Italo, Crea, Filippo, Dall'Armellina, E, Channon, Km, Kharbanda, Rk, Banning, Ap., De Maria GL (ORCID:0000-0003-3572-1855), Porto I (ORCID:0000-0002-9854-5046), Crea F (ORCID:0000-0001-9404-8846), De Maria, Giovanni Luigi, Alkhalil, M, Wolfrum, M, Fahrni, G, Borlotti, A, Gaughran, L, Dawkins, S, Langrish, Jp, Lucking, Aj, Choudhury, Rp, Porto, Italo, Crea, Filippo, Dall'Armellina, E, Channon, Km, Kharbanda, Rk, Banning, Ap., De Maria GL (ORCID:0000-0003-3572-1855), Porto I (ORCID:0000-0002-9854-5046), and Crea F (ORCID:0000-0001-9404-8846)

Abstract

AIMS: The age-thrombus burden-index of microcirculatory resistance (ATI) score is a diagnostic tool able to predict suboptimal myocardial reperfusion before stenting, in patients with ST-elevation myocardial infarction (STEMI). We aimed to validate the ATI score against cardiac magnetic resonance imaging (cMRI). METHODS AND RESULTS: The ATI score was calculated prospectively in 80 STEMI patients. cMRI was performed within 48 hours in all patients and in 50 patients at six-month follow-up to assess the extent of infarct size (IS%) and microvascular obstruction (MVO%). The ATI score was calculated using age (>50=1 point), pre-stenting index of microcirculatory resistance (IMR) (>40 and <100=1 point; ≥100=2 points) and angiographic thrombus score (4=1 point; 5=3 points). ATI score was closely related to final IS% (ATI. Comment in Resistance to flow in the coronary microcirculation - we can measure it but what does it mean?

Published
2017

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