1. Overexpression of Lin28a Aggravates Psoriasis-Like Phenotype by Regulating the Proliferation and Differentiation of Keratinocytes
- Author
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Jang,Soyeon, Jang,Soyoung, Kim,Si-Yong, Ko,Jiwon, Kim,Eungyung, Park,Ji Yeong, Hyung,Hyejin, Lee,Jin Hong, Lim,Su-Geun, Park,Sijun, Yi,Junkoo, Lee,Heon-Jin, Kim,Myoung Ok, Lee,Hyun-Shik, Ryoo,Zae Young, Jang,Soyeon, Jang,Soyoung, Kim,Si-Yong, Ko,Jiwon, Kim,Eungyung, Park,Ji Yeong, Hyung,Hyejin, Lee,Jin Hong, Lim,Su-Geun, Park,Sijun, Yi,Junkoo, Lee,Heon-Jin, Kim,Myoung Ok, Lee,Hyun-Shik, and Ryoo,Zae Young
- Abstract
Soyeon Jang, 1 Soyoung Jang, 1 Si-Yong Kim, 1 Jiwon Ko, 1 Eungyung Kim, 2 Ji Yeong Park, 1 Hyejin Hyung, 1 Jin Hong Lee, 1 Su-Geun Lim, 3 Sijun Park, 3 Junkoo Yi, 4 Heon-Jin Lee, 5 Myoung Ok Kim, 2 Hyun-Shik Lee, 1 Zae Young Ryoo 1 1School of Life Sciences, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, Korea; 2Department of Animal Science and Biotechnology, Kyungpook National University, Daegu, Korea; 3School of Life Science, Kyungpook National University, Daegu, Korea; 4Gyeongsangbukdo Livestock Research Institute, Yeongju, Korea; 5Department of Microbiology and Immunology, School of Dentistry, Kyungpook National University, Daegu, 41940, KoreaCorrespondence: Zae Young Ryoo; Hyun-Shik LeeSchool of Life Science, BK21 FOUR KNU Creative BioResearch Group, Kyungpook National University, Daegu, KoreaTel +82-53-950-7361; +82-53-950-7367Fax +82-53-943-6925; +82-53-943-2762Email jaewoong64@knu.ac.kr; leeh@knu.ac.krPurpose: Psoriasis is a common and well-studied autoimmune skin disease, which is characterized by plaques. The formation of psoriasis plaques occurs through the hyperproliferation and abnormal differentiation of keratinocytes, infiltration of numerous immune cells into the dermis, increased subepidermal angiogenesis, and various autoimmune-associated cytokines and chemokines. According to previous research, Lin28 regulates the let-7 family, and let-7b is associated with psoriasis. However, the link between Lin28 and psoriasis is unclear. In this study, an association was identified between Lin28a and psoriasis progression, which promoted the pathological characteristic of psoriasis in epidermal keratinocytes.Patients and Methods: This study aims to investigate the role of Lin28a and its underlying mechanism in psoriasis through in vivo and in vitro models, which include the Lin28a-overexpressing transgenic (TG) mice and Lin28a-overexpressing human keratinocyte (HaCaT) cell lines, respectively.Results: In vivo and in vitro result
- Published
- 2021