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Magneto-optical nanocomposites possess properties of both magnetic and optical components as novel nanomedicines and demonstrate an immense potential in cancer therapeutics under the application of external stimuli such as alternating magnetic field (AMF) and near-infrared (NIR) laser irradiation. In this thesis, two different hydrophilic and one hydrophobic iron oxide nanoparticles (IONPs) types synthesised by modified co-precipitation methods, acted as a magnetic component. Synthesised IONPs cores (IO1, IO2 and IO3) were further coated with mesoporous silica shell using hexadecyl trimethyl ammonium bromide (CTAB) as a surface directing agent. Upon removal of CTAB from the mesopores by acidic ethanolic washing, the resultant magnetic silica (MS) nanocomposites (MS1, MS2 and MS3) were utilised for loading indocyanine green (ICG), acting as an optical component. The resultant ICG loaded magnetic silica nanocomposites (MSICG) nanocomposites (MS1ICG, MS2ICG and MS3ICG) were novel magneto-optical nanocomposites. Synthesised IONPs, MS and MSICG nanocomposites were extensively characterised and tested for their performance in magnetic hyperthermia therapy (MHT), photothermal therapy (PTT) and photodynamic therapy (PDT) in-vitro using commercial MCF7 breast cancer cell lines. All the synthesised IONPs were spherical in morphology with superparamagnetic properties. Hydrophilic IONPs (IO1 and IO2) exhibited higher saturation magnetisation of 63.6 emu/g and 59.4 emu/g compared to hydrophobic IONPs (IO3) of 49.3 emu/g. Zeta potential measurements indicated that the surface of the IONPs were positively charged. The distinct XRD patterns corresponds to iron oxides. All IONPs showed a distinct Fe-O bond vibration at 550 cm-1 from FTIR analysis due to magnetite phase. In addition, hydrophobic IONPs showed peaks at 2925 and 2852 cm-1, corresponding to -CH2 stretching vibrations due to the presence of oleic acid. Following silica coating, the MS nanocomposites were nearly spherical

Magneto-optical nanocomposites possess properties of both magnetic and optical components as novel nanomedicines and demonstrate an immense potential in cancer therapeutics under the application of external stimuli such as alternating magnetic field (AMF) and near-infrared (NIR) laser irradiation. In this thesis, two different hydrophilic and one hydrophobic iron oxide nanoparticles (IONPs) types synthesised by modified co-precipitation methods, acted as a magnetic component. Synthesised IONPs cores (IO1, IO2 and IO3) were further coated with mesoporous silica shell using hexadecyl trimethyl ammonium bromide (CTAB) as a surface directing agent. Upon removal of CTAB from the mesopores by acidic ethanolic washing, the resultant magnetic silica (MS) nanocomposites (MS1, MS2 and MS3) were utilised for loading indocyanine green (ICG), acting as an optical component. The resultant ICG loaded magnetic silica nanocomposites (MSICG) nanocomposites (MS1ICG, MS2ICG and MS3ICG) were novel magneto-optical nanocomposites. Synthesised IONPs, MS and MSICG nanocomposites were extensively characterised and tested for their performance in magnetic hyperthermia therapy (MHT), photothermal therapy (PTT) and photodynamic therapy (PDT) in-vitro using commercial MCF7 breast cancer cell lines. All the synthesised IONPs were spherical in morphology with superparamagnetic properties. Hydrophilic IONPs (IO1 and IO2) exhibited higher saturation magnetisation of 63.6 emu/g and 59.4 emu/g compared to hydrophobic IONPs (IO3) of 49.3 emu/g. Zeta potential measurements indicated that the surface of the IONPs were positively charged. The distinct XRD patterns corresponds to iron oxides. All IONPs showed a distinct Fe-O bond vibration at 550 cm-1 from FTIR analysis due to magnetite phase. In addition, hydrophobic IONPs showed peaks at 2925 and 2852 cm-1, corresponding to -CH2 stretching vibrations due to the presence of oleic acid. Following silica coating, the MS nanocomposites were nearly spherical

Magneto-optical nanocomposites possess properties of both magnetic and optical components as novel nanomedicines and demonstrate an immense potential in cancer therapeutics under the application of external stimuli such as alternating magnetic field (AMF) and near-infrared (NIR) laser irradiation. In this thesis, two different hydrophilic and one hydrophobic iron oxide nanoparticles (IONPs) types synthesised by modified co-precipitation methods, acted as a magnetic component. Synthesised IONPs cores (IO1, IO2 and IO3) were further coated with mesoporous silica shell using hexadecyl trimethyl ammonium bromide (CTAB) as a surface directing agent. Upon removal of CTAB from the mesopores by acidic ethanolic washing, the resultant magnetic silica (MS) nanocomposites (MS1, MS2 and MS3) were utilised for loading indocyanine green (ICG), acting as an optical component. The resultant ICG loaded magnetic silica nanocomposites (MSICG) nanocomposites (MS1ICG, MS2ICG and MS3ICG) were novel magneto-optical nanocomposites. Synthesised IONPs, MS and MSICG nanocomposites were extensively characterised and tested for their performance in magnetic hyperthermia therapy (MHT), photothermal therapy (PTT) and photodynamic therapy (PDT) in-vitro using commercial MCF7 breast cancer cell lines. All the synthesised IONPs were spherical in morphology with superparamagnetic properties. Hydrophilic IONPs (IO1 and IO2) exhibited higher saturation magnetisation of 63.6 emu/g and 59.4 emu/g compared to hydrophobic IONPs (IO3) of 49.3 emu/g. Zeta potential measurements indicated that the surface of the IONPs were positively charged. The distinct XRD patterns corresponds to iron oxides. All IONPs showed a distinct Fe-O bond vibration at 550 cm-1 from FTIR analysis due to magnetite phase. In addition, hydrophobic IONPs showed peaks at 2925 and 2852 cm-1, corresponding to -CH2 stretching vibrations due to the presence of oleic acid. Following silica coating, the MS nanocomposites were nearly spherical

The role and scope of functional inorganic nanoparticles in biomedical research is well established. Among these, iron oxide nanoparticles (IONPs) have gained maximum attention as they can provide targeting, imaging and therapeutic capabilities. Furthermore, incorporation of organic optical probes with IONPs can significantly enhance the scope and viability of their biomedical applications. Combination of two or more such applications renders multimodality in nanoparticles, which can be exploited to obtain synergistic benefits in disease detection and therapy viz theranostics, which is a key trait of nanoparticles for advanced biomedical applications. This review focuses on the use of IONPs conjugated with organic optical probe/s for multimodal diagnostic and therapeutic applications in vivo.

The role and scope of functional inorganic nanoparticles in biomedical research is well established. Among these, iron oxide nanoparticles (IONPs) have gained maximum attention as they can provide targeting, imaging and therapeutic capabilities. Furthermore, incorporation of organic optical probes with IONPs can significantly enhance the scope and viability of their biomedical applications. Combination of two or more such applications renders multimodality in nanoparticles, which can be exploited to obtain synergistic benefits in disease detection and therapy viz theranostics, which is a key trait of nanoparticles for advanced biomedical applications. This review focuses on the use of IONPs conjugated with organic optical probe/s for multimodal diagnostic and therapeutic applications in vivo.

The role and scope of functional inorganic nanoparticles in biomedical research is well established. Among these, iron oxide nanoparticles (IONPs) have gained maximum attention as they can provide targeting, imaging and therapeutic capabilities. Furthermore, incorporation of organic optical probes with IONPs can significantly enhance the scope and viability of their biomedical applications. Combination of two or more such applications renders multimodality in nanoparticles, which can be exploited to obtain synergistic benefits in disease detection and therapy viz theranostics, which is a key trait of nanoparticles for advanced biomedical applications. This review focuses on the use of IONPs conjugated with organic optical probe/s for multimodal diagnostic and therapeutic applications in vivo.

The role and scope of functional inorganic nanoparticles in biomedical research is well established. Among these, iron oxide nanoparticles (IONPs) have gained maximum attention as they can provide targeting, imaging and therapeutic capabilities. Furthermore, incorporation of organic optical probes with IONPs can significantly enhance the scope and viability of their biomedical applications. Combination of two or more such applications renders multimodality in nanoparticles, which can be exploited to obtain synergistic benefits in disease detection and therapy viz theranostics, which is a key trait of nanoparticles for advanced biomedical applications. This review focuses on the use of IONPs conjugated with organic optical probe/s for multimodal diagnostic and therapeutic applications in vivo.