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1. Duration of breastfeeding and serum PCB 153 concentrations in children.

Author

Lancz, Kinga, Lancz, Kinga, Hertz-Picciotto, Irva, Jusko, Todd A, Murínová, Lubica, Wimmerová, Soňa, Sovčíková, Eva, Dedík, Ladislav, Strémy, Maximilián, Drobná, Beata, Farkašová, Dana, Trnovec, Tomáš, Lancz, Kinga, Lancz, Kinga, Hertz-Picciotto, Irva, Jusko, Todd A, Murínová, Lubica, Wimmerová, Soňa, Sovčíková, Eva, Dedík, Ladislav, Strémy, Maximilián, Drobná, Beata, Farkašová, Dana, and Trnovec, Tomáš

Abstract

Polychlorinated biphenyls (PCBs) are toxic, persistent, and bioaccumulative chemicals which, because of their lipophilic properties, are abundant in human breast milk. Breastfed infants are therefore at risk of being exposed to considerable amounts of PCBs. The commonly used exposure estimations, based solely on breast milk PCB levels and duration of breastfeeding, may lead to exposure misclassification. To improve assessments of exposure to PCBs, we determined PCB 153 serum concentration, as a model substance for PCBs, at the critical time of weaning for each child in 305 breastfed infants from 5 single time point concentration measurements spread over 7 years and data on duration of breastfeeding, using an earlier developed model of the system type. We approximated the dependence of PCB 153 serum concentration, Ctbf, adjusted to cord serum concentration, C0, on nursing period, by a polynomial function Ctbf/C0=0.596+0.278t-0.0047t(2) which reliably predicts exposure to PCB 153 of breastfed infants, important for assessment of dose-outcome relationships. Adjustment of current serum concentrations to cord serum concentration improved validity of exposure assessment.

Published
2015

2. Ratio of cord to maternal serum PCB concentrations in relation to their congener-specific physicochemical properties.

Author

Lancz, Kinga, Lancz, Kinga, Murínová, Lubica, Patayová, Henrieta, Drobná, Beata, Wimmerová, Soňa, Sovčíková, Eva, Kováč, Ján, Farkašová, Dana, Hertz-Picciotto, Irva, Jusko, Todd A, Trnovec, Tomáš, Lancz, Kinga, Lancz, Kinga, Murínová, Lubica, Patayová, Henrieta, Drobná, Beata, Wimmerová, Soňa, Sovčíková, Eva, Kováč, Ján, Farkašová, Dana, Hertz-Picciotto, Irva, Jusko, Todd A, and Trnovec, Tomáš

Abstract

The aim was to characterize placental transfer of some congeners of polychlorinated biphenyls (PCBs) and to relate human in utero exposure to these pollutants to their physicochemical properties. We included into the study 1134 births during the period 2002-2003 from two highly PCB contaminated districts in eastern Slovakia. Concentrations of 15 PCB congeners (IUPAC No. 28, 52, 101, 123(+149), 118, 114, 153, 105, 138(+163), 167, 156(+171), 157, 180, 170, and 189) in umbilical cord (C) and maternal serum (M) were determined. The C/M ratios were significantly related, either positively or inversely depending on parameter, to the logarithm of partition coefficient octanol-water (KOW), to fusion enthalpy at the melting point, molecular weight, water solubility, total surface area of the molecule, solvent accessible surface area, melting point, molar volume, and molecular electronegativity distance vector. We found an inverse association between logKOW and lipid adjusted logC/M (const=1.078, b1=-0.179, p<0.001, R(2)=0.039). Parameters evaluated were interrelated except fusion enthalpy at the melting point and electron affinity vs. solubility. We discuss the possible role of cholesterol as a transplacental transporter of PCBs.

Published
2015

3. The spatial distribution of human exposure to PCBs around a former production site in Slovakia.

Author

Wimmerová, Soňa, Wimmerová, Soňa, Watson, Alan, Drobná, Beata, Šovčíková, Eva, Weber, Roland, Lancz, Kinga, Patayová, Henrieta, Richterová, Denisa, Koštiaková, Vladimíra, Jurečková, Dana, Závacký, Pavol, Strémy, Maximilián, Jusko, Todd A, Palkovičová Murínová, Ľubica, Hertz-Picciotto, Irva, Trnovec, Tomáš, Wimmerová, Soňa, Wimmerová, Soňa, Watson, Alan, Drobná, Beata, Šovčíková, Eva, Weber, Roland, Lancz, Kinga, Patayová, Henrieta, Richterová, Denisa, Koštiaková, Vladimíra, Jurečková, Dana, Závacký, Pavol, Strémy, Maximilián, Jusko, Todd A, Palkovičová Murínová, Ľubica, Hertz-Picciotto, Irva, and Trnovec, Tomáš

Abstract

We evaluated concentrations of 15 PCB congeners in blood serum of 2047 adults, 431 8-9-year old children and 1134 mother-child pairs born in 2001-2003. These subjects were long-standing residents living up to 70 km (to the north) and up to 50 km (to the south) of the former Chemko Strážske PCB production facility in the Michalovce district of Slovakia. We plotted serum concentration against distance from the plant both with and without consideration of the direction of their homes from the site. The decrease in exposure with distance could be described by an exponential function which was dependent on direction and climatic parameters. By kriging we created maps depicting predicted isoconcentration contours for sex- and age-adjusted serum concentration of ∑PCBs for the same group of children, adults and mothers. The principle of our risk analysis was to relate serum concentration data, reflecting PCB body burden, using the critical concentrations established by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES 2010) as thresholds below which the probability of effects on health is regarded as negligible. We conclude that 10 years ago, around 200,000 residents were at risk in this densely populated area. Exposure has since decreased but the mechanism for this has not yet been studied.

Published
2015

4. Prenatal and postnatal serum PCB concentrations and cochlear function in children at 45 months of age.

Author

Jusko, Todd A, Jusko, Todd A, Sisto, Renata, Iosif, Ana-Maria, Moleti, Arturo, Wimmerová, Sonˇa, Lancz, Kinga, Tihányi, Juraj, Sovčiková, Eva, Drobná, Beata, Palkovičová, L'ubica, Jurečková, Dana, Thevenet-Morrison, Kelly, Verner, Marc-André, Sonneborn, Dean, Hertz-Picciotto, Irva, Trnovec, Tomáš, Jusko, Todd A, Jusko, Todd A, Sisto, Renata, Iosif, Ana-Maria, Moleti, Arturo, Wimmerová, Sonˇa, Lancz, Kinga, Tihányi, Juraj, Sovčiková, Eva, Drobná, Beata, Palkovičová, L'ubica, Jurečková, Dana, Thevenet-Morrison, Kelly, Verner, Marc-André, Sonneborn, Dean, Hertz-Picciotto, Irva, and Trnovec, Tomáš

Abstract

BackgroundSome experimental and human data suggest that exposure to polychlorinated biphenyls (PCBs) may induce ototoxicity, though results of previous epidemiologic studies are mixed and generally focus on either prenatal or postnatal PCB concentrations exclusively.ObjectivesOur aim was to evaluate the association between pre- and postnatal PCB concentrations in relation to cochlear status, assessed by distortion product otoacoustic emissions (DPOAEs), and to further clarify the critical periods in development where cochlear status may be most susceptible to PCBs.MethodsA total of 351 children from a birth cohort in eastern Slovakia underwent otoacoustic testing at 45 months of age. Maternal pregnancy, cord, and child 6-, 16-, and 45-month blood samples were collected and analyzed for PCB concentrations. At 45 months of age, DPOAEs were assessed at 11 frequencies in both ears. Multivariate, generalized linear models were used to estimate the associations between PCB concentrations at different ages and DPOAEs, adjusting for potential confounders.ResultsMaternal and cord PCB-153 concentrations were not associated with DPOAEs at 45 months. Higher postnatal PCB concentrations at 6-, 16-, and 45-months of age were associated with lower (poorer) DPOAE amplitudes. When all postnatal PCB exposures were considered as an area-under-the-curve metric, an increase in PCB-153 concentration from the 25th to the 75th percentile was associated with a 1.6-dB SPL (sound pressure level) decrease in DPOAE amplitude (95% CI: -2.6, -0.5; p = 0.003).ConclusionsIn this study, postnatal rather than maternal or cord PCB concentrations were associated with poorer performance on otoacoustic tests at age 45 months.

Published
2014

5. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author

LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Sonnenschein-Van Der Voort, Agnes M M, Arends, Lidia R., De Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, Van Der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W V, Duijts, Liesbeth, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Sonnenschein-Van Der Voort, Agnes M M, Arends, Lidia R., De Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, Van Der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W V, and Duijts, Liesbeth

Published
2014

6. Prenatal and postnatal serum PCB concentrations and cochlear function in children at 45 months of age.

Author

Jusko, Todd A, Jusko, Todd A, Sisto, Renata, Iosif, Ana-Maria, Moleti, Arturo, Wimmerová, Sonˇa, Lancz, Kinga, Tihányi, Juraj, Sovčiková, Eva, Drobná, Beata, Palkovičová, L'ubica, Jurečková, Dana, Thevenet-Morrison, Kelly, Verner, Marc-André, Sonneborn, Dean, Hertz-Picciotto, Irva, Trnovec, Tomáš, Jusko, Todd A, Jusko, Todd A, Sisto, Renata, Iosif, Ana-Maria, Moleti, Arturo, Wimmerová, Sonˇa, Lancz, Kinga, Tihányi, Juraj, Sovčiková, Eva, Drobná, Beata, Palkovičová, L'ubica, Jurečková, Dana, Thevenet-Morrison, Kelly, Verner, Marc-André, Sonneborn, Dean, Hertz-Picciotto, Irva, and Trnovec, Tomáš

Abstract

BackgroundSome experimental and human data suggest that exposure to polychlorinated biphenyls (PCBs) may induce ototoxicity, though results of previous epidemiologic studies are mixed and generally focus on either prenatal or postnatal PCB concentrations exclusively.ObjectivesOur aim was to evaluate the association between pre- and postnatal PCB concentrations in relation to cochlear status, assessed by distortion product otoacoustic emissions (DPOAEs), and to further clarify the critical periods in development where cochlear status may be most susceptible to PCBs.MethodsA total of 351 children from a birth cohort in eastern Slovakia underwent otoacoustic testing at 45 months of age. Maternal pregnancy, cord, and child 6-, 16-, and 45-month blood samples were collected and analyzed for PCB concentrations. At 45 months of age, DPOAEs were assessed at 11 frequencies in both ears. Multivariate, generalized linear models were used to estimate the associations between PCB concentrations at different ages and DPOAEs, adjusting for potential confounders.ResultsMaternal and cord PCB-153 concentrations were not associated with DPOAEs at 45 months. Higher postnatal PCB concentrations at 6-, 16-, and 45-months of age were associated with lower (poorer) DPOAE amplitudes. When all postnatal PCB exposures were considered as an area-under-the-curve metric, an increase in PCB-153 concentration from the 25th to the 75th percentile was associated with a 1.6-dB SPL (sound pressure level) decrease in DPOAE amplitude (95% CI: -2.6, -0.5; p = 0.003).ConclusionsIn this study, postnatal rather than maternal or cord PCB concentrations were associated with poorer performance on otoacoustic tests at age 45 months.

Published
2014

7. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author

LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Sonnenschein-Van Der Voort, Agnes M M, Arends, Lidia R., De Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, Van Der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W V, Duijts, Liesbeth, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Sonnenschein-Van Der Voort, Agnes M M, Arends, Lidia R., De Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, Van Der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W V, and Duijts, Liesbeth

Published
2014

8. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author

LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Sonnenschein-Van Der Voort, Agnes M M, Arends, Lidia R., De Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, Van Der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W V, Duijts, Liesbeth, LS IRAS EEPI ME (Milieu epidemiologie), Risk Assessment of Toxic and Immunomodulatory Agents, IRAS RATIA2, Sonnenschein-Van Der Voort, Agnes M M, Arends, Lidia R., De Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, Van Der Ent, C. Kors, Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, Van Der Gugten, Anne C., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, Cecily C., Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E., Küpers, Leanne K., Lancz, Kinga, Larsen, Pernille S., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, Vincent W V, and Duijts, Liesbeth

Published
2014

9. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children

Author

Sonnenschein-van der Voort, Agnes M. M, Arends, Lidia R., de Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchén, Karel, Eggesbo, Merete, Kors van der Ent, C., Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, AnneC., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iniguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, CecilyC., Kogevinas, Manolis, Kreiner-Moller, Eskil, Kuehni, Claudia E., Kuepers, LeanneK., Lancz, Kinga, Larsen, PernilleS., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne-Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, RadimJ., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, VincentW . V., Duijts, Liesbeth, Sonnenschein-van der Voort, Agnes M. M, Arends, Lidia R., de Jongste, Johan C., Annesi-Maesano, Isabella, Arshad, S. Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C., Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchén, Karel, Eggesbo, Merete, Kors van der Ent, C., Fantini, Maria P., Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, AnneC., Hanke, Wojciech, Henderson, A. John, Heude, Barbara, Iniguez, Carmen, Inskip, Hazel M., Keil, Thomas, Kelleher, CecilyC., Kogevinas, Manolis, Kreiner-Moller, Eskil, Kuehni, Claudia E., Kuepers, LeanneK., Lancz, Kinga, Larsen, PernilleS., Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Nybo Andersen, Anne-Marie, Palkovicova, Lubica, Pike, Katharine C., Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, RadimJ., Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H., Vrijheid, Martine, Jaddoe, VincentW . V., and Duijts, Liesbeth

Abstract

Background: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age less than 37 weeks) and low birth weight (less than 2500 g) with childhood asthma outcomes. Results: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P less than. 05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weigh

Published
2014
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10. Preterm birth, infant weight gain, and childhood asthma risk:a meta-analysis of 147,000 European children

Author

Sonnenschein-van der Voort, Agnes M M, Arends, Lidia R, de Jongste, Johan C, Annesi-Maesano, Isabella, Arshad, S Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C, Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, van der Ent, C Kors, Fantini, Maria P, Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, Anne C, Hanke, Wojciech, Henderson, A John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M, Keil, Thomas, Kelleher, Cecily C, Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E, Küpers, Leanne K, Lancz, Kinga, Larsen, Pernille S, Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Andersen, Anne-Marie Nybo, Palkovicova, Lubica, Pike, Katharine C, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H, Vrijheid, Martine, Jaddoe, Vincent W V, Duijts, Liesbeth, Sonnenschein-van der Voort, Agnes M M, Arends, Lidia R, de Jongste, Johan C, Annesi-Maesano, Isabella, Arshad, S Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C, Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, van der Ent, C Kors, Fantini, Maria P, Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, Anne C, Hanke, Wojciech, Henderson, A John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M, Keil, Thomas, Kelleher, Cecily C, Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E, Küpers, Leanne K, Lancz, Kinga, Larsen, Pernille S, Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Andersen, Anne-Marie Nybo, Palkovicova, Lubica, Pike, Katharine C, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H, Vrijheid, Martine, Jaddoe, Vincent W V, and Duijts, Liesbeth

Abstract

BACKGROUND: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results.OBJECTIVES: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years).METHODS: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes.RESULTS: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27).CONCLUSION: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower b

Published
2014

11. Preterm birth, infant weight gain, and childhood asthma risk:a meta-analysis of 147,000 European children

Author

Sonnenschein-van der Voort, Agnes M M, Arends, Lidia R, de Jongste, Johan C, Annesi-Maesano, Isabella, Arshad, S Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C, Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, van der Ent, C Kors, Fantini, Maria P, Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, Anne C, Hanke, Wojciech, Henderson, A John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M, Keil, Thomas, Kelleher, Cecily C, Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E, Küpers, Leanne K, Lancz, Kinga, Larsen, Pernille S, Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Andersen, Anne-Marie Nybo, Palkovicova, Lubica, Pike, Katharine C, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H, Vrijheid, Martine, Jaddoe, Vincent W V, Duijts, Liesbeth, Sonnenschein-van der Voort, Agnes M M, Arends, Lidia R, de Jongste, Johan C, Annesi-Maesano, Isabella, Arshad, S Hasan, Barros, Henrique, Basterrechea, Mikel, Bisgaard, Hans, Chatzi, Leda, Corpeleijn, Eva, Correia, Sofia, Craig, Leone C, Devereux, Graham, Dogaru, Cristian, Dostal, Miroslav, Duchen, Karel, Eggesbø, Merete, van der Ent, C Kors, Fantini, Maria P, Forastiere, Francesco, Frey, Urs, Gehring, Ulrike, Gori, Davide, van der Gugten, Anne C, Hanke, Wojciech, Henderson, A John, Heude, Barbara, Iñiguez, Carmen, Inskip, Hazel M, Keil, Thomas, Kelleher, Cecily C, Kogevinas, Manolis, Kreiner-Møller, Eskil, Kuehni, Claudia E, Küpers, Leanne K, Lancz, Kinga, Larsen, Pernille S, Lau, Susanne, Ludvigsson, Johnny, Mommers, Monique, Andersen, Anne-Marie Nybo, Palkovicova, Lubica, Pike, Katharine C, Pizzi, Costanza, Polanska, Kinga, Porta, Daniela, Richiardi, Lorenzo, Roberts, Graham, Schmidt, Anne, Sram, Radim J, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Viljoen, Karien, Wijga, Alet H, Vrijheid, Martine, Jaddoe, Vincent W V, and Duijts, Liesbeth

Abstract

BACKGROUND: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results.OBJECTIVES: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years).METHODS: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes.RESULTS: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27).CONCLUSION: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower b

Published
2014

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