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Report of a phenomenological qualitative experience that, through photobiography, presents how the process of self-recognition occurred through belly dancing. The objective was to understand how body expression through belly dancing presents the author in the world. She recognized herself as a woman, rescuing self-image, self-esteem and female empowerment., Relato de experiência de base qualitativa fenomenológica que pela fotobiografia apresenta como ocorreu processo de autorreconhecimento pela dança do ventre. Objetivou compreender como a expressão corporal pela dança do ventre apresenta a autora no mundo. Reconheceu-se como mulher, resgatando autoimagem, autoestima e empoderamento feminino.

Patrícia Nunes Mesquita,1 Ana Paula Dornelas Leão Leite,2 Stella das Chagas Crisóstomo,1 Enio Veras Filho,1 Lucas da Cunha Xavier,1 Francisco Bandeira1 1Unit of Endocrinology, Diabetes and Bone Diseases, Hospital Agamenon Magalhães, 2Department of Radiology, University of Pernambuco, Cardiac Emergency Hospital of Pernambuco, Recife, Pernambuco, Brazil Rationale: Given that the diagnosis of primary hyperparathyroidism (PHPT) is given at an increasingly less-symptomatic phase, and the literature data on the cardiovascular risk of patients with normocalcemic primary hyperparathyroidism (NPHPT) are controversial, the coronary calcium score (CCS), which is correlated with coronary artery disease, may be useful for clarifying the association between cardiovascular risk and NPHPT.Objective: This research aims to describe the CCS and the clinical and laboratory variables of patients with NPHPT compared with a control group and to verify the presence of an association between NPHPT and CCS.Study population and methods: A questionnaire on anthropometric data (weight, height, waist circumference, and blood pressure) was used, laboratory examinations (estimations of glucose, glycated hemoglobin [HbA1c], total cholesterol [TC] and its fractions, triglycerides, creatinine, calcium, parathyroid hormone, and 25-OH vitamin D) were conducted, and computerized tomography was carried out to measure the CCS in 13 patients diagnosed with NPHPT and 16 controls.Results: There was no association between NPHPT and altered CCS (odds ratio [OR]: 0.27; 95% confidence interval [CI]: 0.05–1.26; p=0.095). Differences between the case and control groups were found in terms of body mass index (BMI) (26.97 kg/m2 vs 31.53 kg/m2, respectively; p=0.044), HbA1c (5.59% vs 6.62%; p=0.000), and TC (188.07 mg/dL vs 220.64 mg/dL; p=0.088). After adjustment for potential confounders, no statistical significance was observ

Since the 80s, the country was characterized by the large number of emigrants who went, in general, to the United States and Europe. This phenomenon has brought long negative effects for Brazil, in that it had a brain drain ( brain drain ), ie, our skilled labor is directed to these regions, seeking new career opportunities. However, this scenario is changing at the present conjuncture. The Brazil in recent years, as regional power, has become one of the countries with the highest rates of development, and is currently the 6th world economy. Thus, this communication is scoped to analyze the turning point that crosses Brazil in order to verify if, indeed, the country was experiencing a transformation in their migratory pattern, coming to assume the role of importer of labor. Perhaps it is still too early to talk about reversing the flow, but it is possible, from the empirical analysis, notice signs of change and, therefore, there is need to investigate its causes., Desde a década de 80, o país era caracterizado pelo grande número de emigrantes que se dirigiam, em geral, para os Estados Unidos e para a Europa. Esse fenômeno trouxe durante muito tempo efeitos negativos para o Brasil, na medida em que tínhamos uma fuga de cérebros (brain drain), ou seja, nossa mão de obra qualificada se direcionava a estas regiões, buscando novas oportunidades profissionais. Contudo, esse panorama vem se alterando na conjuntura mais atual. O Brasil nos últimos anos, além de uma potência regional, tornou-se um dos países com maiores índices de desenvolvimento, sendo hoje a 6ª economia mundial. Sendo assim, esta comunicação tem como escopo analisar o momento de inflexão que o Brasil atravessa com vistas a verificar se, de fato, o país estaria experimentando uma transformação em seu perfil migratório, passando a assumir o papel de importador de mão de obra. Talvez ainda seja muito cedo para falar em inversão dos fluxos, mas já é possível, a partir da análise empírica, observar indícios de mudanças e, por essa razão, há a necessidade de investigarmos suas causas.

Since the 80s, the country was characterized by the large number of emigrants who went, in general, to the United States and Europe. This phenomenon has brought long negative effects for Brazil, in that it had a brain drain ( brain drain ), ie, our skilled labor is directed to these regions, seeking new career opportunities. However, this scenario is changing at the present conjuncture. The Brazil in recent years, as regional power, has become one of the countries with the highest rates of development, and is currently the 6th world economy. Thus, this communication is scoped to analyze the turning point that crosses Brazil in order to verify if, indeed, the country was experiencing a transformation in their migratory pattern, coming to assume the role of importer of labor. Perhaps it is still too early to talk about reversing the flow, but it is possible, from the empirical analysis, notice signs of change and, therefore, there is need to investigate its causes., Desde a década de 80, o país era caracterizado pelo grande número de emigrantes que se dirigiam, em geral, para os Estados Unidos e para a Europa. Esse fenômeno trouxe durante muito tempo efeitos negativos para o Brasil, na medida em que tínhamos uma fuga de cérebros (brain drain), ou seja, nossa mão de obra qualificada se direcionava a estas regiões, buscando novas oportunidades profissionais. Contudo, esse panorama vem se alterando na conjuntura mais atual. O Brasil nos últimos anos, além de uma potência regional, tornou-se um dos países com maiores índices de desenvolvimento, sendo hoje a 6ª economia mundial. Sendo assim, esta comunicação tem como escopo analisar o momento de inflexão que o Brasil atravessa com vistas a verificar se, de fato, o país estaria experimentando uma transformação em seu perfil migratório, passando a assumir o papel de importador de mão de obra. Talvez ainda seja muito cedo para falar em inversão dos fluxos, mas já é possível, a partir da análise empírica, observar indícios de mudanças e, por essa razão, há a necessidade de investigarmos suas causas.

Since the 80s, the country was characterized by the large number of emigrants who went, in general, to the United States and Europe. This phenomenon has brought long negative effects for Brazil, in that it had a brain drain ( brain drain ), ie, our skilled labor is directed to these regions, seeking new career opportunities. However, this scenario is changing at the present conjuncture. The Brazil in recent years, as regional power, has become one of the countries with the highest rates of development, and is currently the 6th world economy. Thus, this communication is scoped to analyze the turning point that crosses Brazil in order to verify if, indeed, the country was experiencing a transformation in their migratory pattern, coming to assume the role of importer of labor. Perhaps it is still too early to talk about reversing the flow, but it is possible, from the empirical analysis, notice signs of change and, therefore, there is need to investigate its causes., Desde a década de 80, o país era caracterizado pelo grande número de emigrantes que se dirigiam, em geral, para os Estados Unidos e para a Europa. Esse fenômeno trouxe durante muito tempo efeitos negativos para o Brasil, na medida em que tínhamos uma fuga de cérebros (brain drain), ou seja, nossa mão de obra qualificada se direcionava a estas regiões, buscando novas oportunidades profissionais. Contudo, esse panorama vem se alterando na conjuntura mais atual. O Brasil nos últimos anos, além de uma potência regional, tornou-se um dos países com maiores índices de desenvolvimento, sendo hoje a 6ª economia mundial. Sendo assim, esta comunicação tem como escopo analisar o momento de inflexão que o Brasil atravessa com vistas a verificar se, de fato, o país estaria experimentando uma transformação em seu perfil migratório, passando a assumir o papel de importador de mão de obra. Talvez ainda seja muito cedo para falar em inversão dos fluxos, mas já é possível, a partir da análise empírica, observar indícios de mudanças e, por essa razão, há a necessidade de investigarmos suas causas.

Models of mammalian regulatory networks controlling gene expression have been inferred from genomic data but have largely not been validated. We present an unbiased strategy to systematically perturb candidate regulators and monitor cellular transcriptional responses. We applied this approach to derive regulatory networks that control the transcriptional response of mouse primary dendritic cells to pathogens. Our approach revealed the regulatory functions of 125 transcription factors, chromatin modifiers, and RNA binding proteins, which enabled the construction of a network model consisting of 24 core regulators and 76 fine-tuners that help to explain how pathogen-sensing pathways achieve specificity. This study establishes a broadly applicable, comprehensive, and unbiased approach to reveal the wiring and functions of a regulatory network controlling a major transcriptional response in primary mammalian cells., Burroughs Wellcome Fund (Career Award at the Scientific Interface), National Institutes of Health (U.S.) (Pioneer Award), Alfred P. Sloan Foundation

Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2012., Cataloged from PDF version of thesis., Includes bibliographical references (p. 141-149)., The reconstruction of regulatory networks is one of the most challenging tasks in systems biology. Although some models for inferring regulatory networks can make useful predictions about the wiring and mechanisms of molecular interactions, these approaches are still limited and there is a strong need to develop increasingly universal and accurate approaches for network reconstruction. This problem is particularly challenging in mammals, due to the higher complexity of mammalian regulatory networks and limitations in experimental manipulation. In this thesis, I present three systematic approachs to reconstruct, analyse and refine models of gene regulation. In Chapter 1, I devise a method for deriving an observational model from temporal genomic profiles. I use it to choose targets for perturbation experiments in order to determine a network controlling the responses of mouse primary dendritic cells to stimulation with pathogen components. In Chapter 2, I introduce the algorithm Exigo, for identifying essential interactions in regulatory networks reconstructed from experimental data where regulators have been silenced, using a network reduction strategy. Exigo outperforms previous approaches on simulated data, uncovers the core network structure when applied to real networks derived from perturbation studies in mammals, and improves the performance of network inference methods. Lastly, I introduce in Chapter 3 an approach to learn a module network from multiple highthroughput assays. Analysis of a diffuse large B-cell lymphoma dataset identifies candidate regulator genes, microRNAs and copy number aberrations with biological, and possibly therapeutic, importance., by Ana Paula Santos Botelho Oliveira Leite., Ph.D.

El artículo se inserta en la línea de estudios sobre el trabajo de profesionales que manejan el trabajo de otros trabajadores. Se privilegia el punto de vista de la actividad, a menudo ausente o subordinado a los demás (financiero, comercial, sindical). Bajo la influencia del principio metodológico de la confrontación, se hizo uso de la técnica de “instrucciones a la doble”. El método empleado involucró tres fases: una entrevista dialógica semiestructurada con la gerente; un diálogo de instrucciones a la doble y un diálogo de autoconfrontación. Se dan pistas para avanzar en a línea de investigación de un gerenciamiento que acepta el desafío de incorporar los procedimientos de gestión presentes en las situaciones concretas de trabajo, a través de las actividades de cada uno de los que trabajan.