1. T 1 mapping performance and measurement repeatability: Results from the multi-national T 1 mapping standardization phantom program (T1MES)
- Author
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Captur, G, Bhandari, A, Bruhl, R, Ittermann, B, Keenan, K, Yang, Y, Eames, R, Benedetti, G, Torlasco, C, Ricketts, L, Boubertakh, R, Fatih, N, Greenwood, J, Paulis, L, Lawton, C, Bucciarelli-Ducci, C, Lamb, H, Steeds, R, Leung, S, Berry, C, Valentin, S, Flett, A, De Lange, C, Decobelli, F, Viallon, M, Croisille, P, Higgins, D, Greiser, A, Pang, W, Hamilton-Craig, C, Strugnell, W, Dresselaers, T, Barison, A, Dawson, D, Taylor, A, Mongeon, F, Plein, S, Messroghli, D, Al-Mallah, M, Grieve, S, Lombardi, M, Jang, J, Salerno, M, Chaturvedi, N, Kellman, P, Bluemke, D, Nezafat, R, Gatehouse, P, Moon, J, Captur G., Bhandari A., Bruhl R., Ittermann B., Keenan K. E., Yang Y., Eames R. J., Benedetti G., Torlasco C., Ricketts L., Boubertakh R., Fatih N., Greenwood J. P., Paulis L. E. M., Lawton C. B., Bucciarelli-Ducci C., Lamb H. J., Steeds R., Leung S. W., Berry C., Valentin S., Flett A., De Lange C., Decobelli F., Viallon M., Croisille P., Higgins D. M., Greiser A., Pang W., Hamilton-Craig C., Strugnell W. E., Dresselaers T., Barison A., Dawson D., Taylor A. J., Mongeon F. -P., Plein S., Messroghli D., Al-Mallah M., Grieve S. M., Lombardi M., Jang J., Salerno M., Chaturvedi N., Kellman P., Bluemke D. A., Nezafat R., Gatehouse P., Moon J. C., Captur, G, Bhandari, A, Bruhl, R, Ittermann, B, Keenan, K, Yang, Y, Eames, R, Benedetti, G, Torlasco, C, Ricketts, L, Boubertakh, R, Fatih, N, Greenwood, J, Paulis, L, Lawton, C, Bucciarelli-Ducci, C, Lamb, H, Steeds, R, Leung, S, Berry, C, Valentin, S, Flett, A, De Lange, C, Decobelli, F, Viallon, M, Croisille, P, Higgins, D, Greiser, A, Pang, W, Hamilton-Craig, C, Strugnell, W, Dresselaers, T, Barison, A, Dawson, D, Taylor, A, Mongeon, F, Plein, S, Messroghli, D, Al-Mallah, M, Grieve, S, Lombardi, M, Jang, J, Salerno, M, Chaturvedi, N, Kellman, P, Bluemke, D, Nezafat, R, Gatehouse, P, Moon, J, Captur G., Bhandari A., Bruhl R., Ittermann B., Keenan K. E., Yang Y., Eames R. J., Benedetti G., Torlasco C., Ricketts L., Boubertakh R., Fatih N., Greenwood J. P., Paulis L. E. M., Lawton C. B., Bucciarelli-Ducci C., Lamb H. J., Steeds R., Leung S. W., Berry C., Valentin S., Flett A., De Lange C., Decobelli F., Viallon M., Croisille P., Higgins D. M., Greiser A., Pang W., Hamilton-Craig C., Strugnell W. E., Dresselaers T., Barison A., Dawson D., Taylor A. J., Mongeon F. -P., Plein S., Messroghli D., Al-Mallah M., Grieve S. M., Lombardi M., Jang J., Salerno M., Chaturvedi N., Kellman P., Bluemke D. A., Nezafat R., Gatehouse P., and Moon J. C.
- Abstract
Background: The T 1 Mapping and Extracellular volume (ECV) Standardization (T1MES) program explored T 1 mapping quality assurance using a purpose-developed phantom with Food and Drug Administration (FDA) and Conformité Européenne (CE) regulatory clearance. We report T 1 measurement repeatability across centers describing sequence, magnet, and vendor performance. Methods: Phantoms batch-manufactured in August 2015 underwent 2 years of structural imaging, B 0 and B 1, and "reference" slow T 1 testing. Temperature dependency was evaluated by the United States National Institute of Standards and Technology and by the German Physikalisch-Technische Bundesanstalt. Center-specific T 1 mapping repeatability (maximum one scan per week to minimum one per quarter year) was assessed over mean 358 (maximum 1161) days on 34 1.5 T and 22 3 T magnets using multiple T 1 mapping sequences. Image and temperature data were analyzed semi-automatically. Repeatability of serial T 1 was evaluated in terms of coefficient of variation (CoV), and linear mixed models were constructed to study the interplay of some of the known sources of T 1 variation. Results: Over 2 years, phantom gel integrity remained intact (no rips/tears), B 0 and B 1 homogenous, and "reference" T 1 stable compared to baseline (% change at 1.5 T, 1.95 ± 1.39%; 3 T, 2.22 ± 1.44%). Per degrees Celsius, 1.5 T, T 1 (MOLLI 5s(3s)3s) increased by 11.4 ms in long native blood tubes and decreased by 1.2 ms in short post-contrast myocardium tubes. Agreement of estimated T 1 times with "reference" T 1 was similar across Siemens and Philips CMR systems at both field strengths (adjusted R 2 ranges for both field strengths, 0.99-1.00). Over 1 year, many 1.5 T and 3 T sequences/magnets were repeatable with mean CoVs < 1 and 2% respectively. Repeatability was narrower for 1.5 T over 3 T. Within T1MES repeatability for native T 1 was narrow for several sequences, for example, at 1.5 T, Siemens MOLLI 5s(3s)3s prototype number 448B (
- Published
- 2020