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12 results on '"MALANGONE C."'

1. Medium and long-term efficacy of psychoeducational family intervention for bipolar I disorder: Results from a real-world, multicentric study

Author

Luciano, M, Sampogna, G, Del Vecchio, V, Giallonardo, V, Di Cerbo, A, Palummo, C, Malangone, C, Lampis, D, Veltro, F, Bardicchia, F, Ciampini, G, Orlandi, E, Moroni, A, Biondi, S, Piselli, M, Menculini, G, Nicolo, G, Pompili, E, Carra, G, Fiorillo, A, Luciano M., Sampogna G., Del Vecchio V., Giallonardo V., Di Cerbo A., Palummo C., Malangone C., Lampis D., Veltro F., Bardicchia F., Ciampini G., Orlandi E., Moroni A., Biondi S., Piselli M., Menculini G., Nicolo G., Pompili E., Carra G., Fiorillo A., Luciano, M, Sampogna, G, Del Vecchio, V, Giallonardo, V, Di Cerbo, A, Palummo, C, Malangone, C, Lampis, D, Veltro, F, Bardicchia, F, Ciampini, G, Orlandi, E, Moroni, A, Biondi, S, Piselli, M, Menculini, G, Nicolo, G, Pompili, E, Carra, G, Fiorillo, A, Luciano M., Sampogna G., Del Vecchio V., Giallonardo V., Di Cerbo A., Palummo C., Malangone C., Lampis D., Veltro F., Bardicchia F., Ciampini G., Orlandi E., Moroni A., Biondi S., Piselli M., Menculini G., Nicolo G., Pompili E., Carra G., and Fiorillo A.

Abstract

Objectives: This study aims to explore the long-term efficacy of a psychoeducational family intervention (PFI) in bipolar I disorder at one and five years post-intervention in terms of improvement of: (1) patients’ symptoms and global functioning and (2) relatives’ objective and subjective burden and coping strategies. Methods: This is a multicentre, real-world, controlled, outpatient trial. Recruited patients and key-relatives were consecutively allocated to the experimental intervention or treatment as usual. Patients were assessed at baseline, and after one and five years. Results: One hundred and thirty-seventh number families have been recruited; 70 have been allocated to the experimental intervention, and 67 have been allocated to the control group. We observed an increasing positive effect of the PFI on patients’ clinical status, global functioning and objective and subjective burden after one year. We also found a reduction in the levels of relatives’ objective and subjective burden and a significant improvement in the levels of perceived professional support and of coping strategies. The efficacy of PFI on patients’ clinical status was maintained at five years from the end of the intervention, in terms of relapses, hospitalizations and suicide attempts. Conclusions: The study showed that the provision of PFI in real-world settings is associated with a significant improvement of patients’ and relatives’ mental health and psychosocial functioning in the long term. We found that the clinical efficacy of the intervention, in terms of reduction of patients’ relapses, hospitalization and suicide attempts, persists after 5 years. It is advisable that PFI is provided to patients with BD I in routine practice.

Published
2022

2. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

Author

Ahouidi, A., Ali, M, Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amato, R., Amenga-Etego, L., Andagalu, B., Anderson, T.J., Andrianaranjaka, V., Apinjoh, T., Ariani, C., Ashley, E.A., Auburn, S., Awandare, G.A., Ba, H., Baraka, V., Barry, A.E., Bejon, P., Bertin, G.I., Boni, M.F., Borrmann, S., Bousema, T., Branch, O., Bull, P.C., Busby, G.B.J., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D., Craig, A., D'Alessandro, U., Dama, S., Day, N.P., Denis, B., Diakite, M., Djimdé, A., Dolecek, C., Dondorp, A.M., Drakeley, C., Drury, E., Duffy, P., Echeverry, D.F., Egwang, T.G., Erko, B., Fairhurst, R.M., Faiz, A., Fanello, C.A., Fukuda, M.M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Hamilton, W.L., Harrison, G.L.A., Hart, L. 't, Henrichs, C., Hien, T.T., Hill, C.A., Hodgson, A., Hubbart, C., Imwong, M., Ishengoma, D.S., Jackson, S.A., Jacob, C.G., Jeffery, B., Jeffreys, A.E., Johnson, K.J., Jyothi, D., Kamaliddin, C., Kamau, E., Kekre, M., Kluczynski, K., Kochakarn, T., Konaté, A., Kwiatkowski, D.P., Kyaw, M.P., Lim, P., Lon, C., Loua, K.M., Maïga-Ascofaré, O., Malangone, C., Manske, M., Marfurt, J., Marsh, K., Mayxay, M., Miles, A., Miotto, O., Mobegi, V., Mokuolu, O.A., Montgomery, J., Mueller, I., Newton, P.N., Nguyen, T., Nguyen, T.N.D., Noedl, H., Nosten, F., Noviyanti, R., Nzila, A., Ochola-Oyier, L.I., Ahouidi, A., Ali, M, Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amato, R., Amenga-Etego, L., Andagalu, B., Anderson, T.J., Andrianaranjaka, V., Apinjoh, T., Ariani, C., Ashley, E.A., Auburn, S., Awandare, G.A., Ba, H., Baraka, V., Barry, A.E., Bejon, P., Bertin, G.I., Boni, M.F., Borrmann, S., Bousema, T., Branch, O., Bull, P.C., Busby, G.B.J., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D., Craig, A., D'Alessandro, U., Dama, S., Day, N.P., Denis, B., Diakite, M., Djimdé, A., Dolecek, C., Dondorp, A.M., Drakeley, C., Drury, E., Duffy, P., Echeverry, D.F., Egwang, T.G., Erko, B., Fairhurst, R.M., Faiz, A., Fanello, C.A., Fukuda, M.M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Hamilton, W.L., Harrison, G.L.A., Hart, L. 't, Henrichs, C., Hien, T.T., Hill, C.A., Hodgson, A., Hubbart, C., Imwong, M., Ishengoma, D.S., Jackson, S.A., Jacob, C.G., Jeffery, B., Jeffreys, A.E., Johnson, K.J., Jyothi, D., Kamaliddin, C., Kamau, E., Kekre, M., Kluczynski, K., Kochakarn, T., Konaté, A., Kwiatkowski, D.P., Kyaw, M.P., Lim, P., Lon, C., Loua, K.M., Maïga-Ascofaré, O., Malangone, C., Manske, M., Marfurt, J., Marsh, K., Mayxay, M., Miles, A., Miotto, O., Mobegi, V., Mokuolu, O.A., Montgomery, J., Mueller, I., Newton, P.N., Nguyen, T., Nguyen, T.N.D., Noedl, H., Nosten, F., Noviyanti, R., Nzila, A., and Ochola-Oyier, L.I.

Abstract

Contains fulltext : 238195.pdf (Publisher’s version ) (Open Access), MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed. Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.

Published
2021

3. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples.

Author

MalariaGEN, Ahouidi, A, Ali, M, Almagro-Garcia, J, Amambua-Ngwa, A, Amaratunga, C, Amato, R, Amenga-Etego, L, Andagalu, B, Anderson, TJC, Andrianaranjaka, V, Apinjoh, T, Ariani, C, Ashley, EA, Auburn, S, Awandare, GA, Ba, H, Baraka, V, Barry, Alyssa, Bejon, P, Bertin, GI, Boni, MF, Borrmann, S, Bousema, T, Branch, O, Bull, PC, Busby, GBJ, Chookajorn, T, Chotivanich, K, Claessens, A, Conway, D, Craig, A, D'Alessandro, U, Dama, S, Day, NP, Denis, B, Diakite, M, Djimdé, A, Dolecek, C, Dondorp, AM, Drakeley, C, Drury, E, Duffy, P, Echeverry, DF, Egwang, TG, Erko, B, Fairhurst, RM, Faiz, A, Fanello, CA, Fukuda, MM, Gamboa, D, Ghansah, A, Golassa, L, Goncalves, S, Hamilton, WL, Harrison, GLA, Hart, L, Henrichs, C, Hien, TT, Hill, CA, Hodgson, A, Hubbart, C, Imwong, M, Ishengoma, DS, Jackson, SA, Jacob, CG, Jeffery, B, Jeffreys, AE, Johnson, KJ, Jyothi, D, Kamaliddin, C, Kamau, E, Kekre, M, Kluczynski, K, Kochakarn, T, Konaté, A, Kwiatkowski, DP, Kyaw, MP, Lim, P, Lon, C, Loua, KM, Maïga-Ascofaré, O, Malangone, C, Manske, M, Marfurt, J, Marsh, K, Mayxay, M, Miles, A, Miotto, O, Mobegi, V, Mokuolu, OA, Montgomery, J, Mueller, I, Newton, PN, Nguyen, T, Nguyen, T-N, Noedl, H, Nosten, F, Noviyanti, R, Nzila, A, Ochola-Oyier, LI, Ocholla, H, Oduro, A, Omedo, I, Onyamboko, MA, Ouedraogo, J-B, Oyebola, K, Pearson, RD, Peshu, N, Phyo, AP, Plowe, CV, Price, RN, Pukrittayakamee, S, Randrianarivelojosia, M, Rayner, JC, Ringwald, P, Rockett, KA, Rowlands, K, Ruiz, L, Saunders, D, Shayo, A, Siba, P, Simpson, VJ, Stalker, J, Su, X-Z, Sutherland, C, Takala-Harrison, S, Tavul, L, Thathy, V, Tshefu, A, Verra, F, Vinetz, J, Wellems, TE, Wendler, J, White, NJ, Wright, I, Yavo, W, Ye, H, MalariaGEN, Ahouidi, A, Ali, M, Almagro-Garcia, J, Amambua-Ngwa, A, Amaratunga, C, Amato, R, Amenga-Etego, L, Andagalu, B, Anderson, TJC, Andrianaranjaka, V, Apinjoh, T, Ariani, C, Ashley, EA, Auburn, S, Awandare, GA, Ba, H, Baraka, V, Barry, Alyssa, Bejon, P, Bertin, GI, Boni, MF, Borrmann, S, Bousema, T, Branch, O, Bull, PC, Busby, GBJ, Chookajorn, T, Chotivanich, K, Claessens, A, Conway, D, Craig, A, D'Alessandro, U, Dama, S, Day, NP, Denis, B, Diakite, M, Djimdé, A, Dolecek, C, Dondorp, AM, Drakeley, C, Drury, E, Duffy, P, Echeverry, DF, Egwang, TG, Erko, B, Fairhurst, RM, Faiz, A, Fanello, CA, Fukuda, MM, Gamboa, D, Ghansah, A, Golassa, L, Goncalves, S, Hamilton, WL, Harrison, GLA, Hart, L, Henrichs, C, Hien, TT, Hill, CA, Hodgson, A, Hubbart, C, Imwong, M, Ishengoma, DS, Jackson, SA, Jacob, CG, Jeffery, B, Jeffreys, AE, Johnson, KJ, Jyothi, D, Kamaliddin, C, Kamau, E, Kekre, M, Kluczynski, K, Kochakarn, T, Konaté, A, Kwiatkowski, DP, Kyaw, MP, Lim, P, Lon, C, Loua, KM, Maïga-Ascofaré, O, Malangone, C, Manske, M, Marfurt, J, Marsh, K, Mayxay, M, Miles, A, Miotto, O, Mobegi, V, Mokuolu, OA, Montgomery, J, Mueller, I, Newton, PN, Nguyen, T, Nguyen, T-N, Noedl, H, Nosten, F, Noviyanti, R, Nzila, A, Ochola-Oyier, LI, Ocholla, H, Oduro, A, Omedo, I, Onyamboko, MA, Ouedraogo, J-B, Oyebola, K, Pearson, RD, Peshu, N, Phyo, AP, Plowe, CV, Price, RN, Pukrittayakamee, S, Randrianarivelojosia, M, Rayner, JC, Ringwald, P, Rockett, KA, Rowlands, K, Ruiz, L, Saunders, D, Shayo, A, Siba, P, Simpson, VJ, Stalker, J, Su, X-Z, Sutherland, C, Takala-Harrison, S, Tavul, L, Thathy, V, Tshefu, A, Verra, F, Vinetz, J, Wellems, TE, Wendler, J, White, NJ, Wright, I, Yavo, W, and Ye, H

Abstract

MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed.  Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.

Published
2021

4. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples.

Author

MalariaGEN, Ahouidi, A, Ali, M, Almagro-Garcia, J, Amambua-Ngwa, A, Amaratunga, C, Amato, R, Amenga-Etego, L, Andagalu, B, Anderson, TJC, Andrianaranjaka, V, Apinjoh, T, Ariani, C, Ashley, EA, Auburn, S, Awandare, GA, Ba, H, Baraka, V, Barry, AE, Bejon, P, Bertin, GI, Boni, MF, Borrmann, S, Bousema, T, Branch, O, Bull, PC, Busby, GBJ, Chookajorn, T, Chotivanich, K, Claessens, A, Conway, D, Craig, A, D'Alessandro, U, Dama, S, Day, NP, Denis, B, Diakite, M, Djimdé, A, Dolecek, C, Dondorp, AM, Drakeley, C, Drury, E, Duffy, P, Echeverry, DF, Egwang, TG, Erko, B, Fairhurst, RM, Faiz, A, Fanello, CA, Fukuda, MM, Gamboa, D, Ghansah, A, Golassa, L, Goncalves, S, Hamilton, WL, Harrison, GLA, Hart, L, Henrichs, C, Hien, TT, Hill, CA, Hodgson, A, Hubbart, C, Imwong, M, Ishengoma, DS, Jackson, SA, Jacob, CG, Jeffery, B, Jeffreys, AE, Johnson, KJ, Jyothi, D, Kamaliddin, C, Kamau, E, Kekre, M, Kluczynski, K, Kochakarn, T, Konaté, A, Kwiatkowski, DP, Kyaw, MP, Lim, P, Lon, C, Loua, KM, Maïga-Ascofaré, O, Malangone, C, Manske, M, Marfurt, J, Marsh, K, Mayxay, M, Miles, A, Miotto, O, Mobegi, V, Mokuolu, OA, Montgomery, J, Mueller, I, Newton, PN, Nguyen, T, Nguyen, T-N, Noedl, H, Nosten, F, Noviyanti, R, Nzila, A, Ochola-Oyier, LI, Ocholla, H, Oduro, A, Omedo, I, Onyamboko, MA, Ouedraogo, J-B, Oyebola, K, Pearson, RD, Peshu, N, Phyo, AP, Plowe, CV, Price, RN, Pukrittayakamee, S, Randrianarivelojosia, M, Rayner, JC, Ringwald, P, Rockett, KA, Rowlands, K, Ruiz, L, Saunders, D, Shayo, A, Siba, P, Simpson, VJ, Stalker, J, Su, X-Z, Sutherland, C, Takala-Harrison, S, Tavul, L, Thathy, V, Tshefu, A, Verra, F, Vinetz, J, Wellems, TE, Wendler, J, White, NJ, Wright, I, Yavo, W, Ye, H, MalariaGEN, Ahouidi, A, Ali, M, Almagro-Garcia, J, Amambua-Ngwa, A, Amaratunga, C, Amato, R, Amenga-Etego, L, Andagalu, B, Anderson, TJC, Andrianaranjaka, V, Apinjoh, T, Ariani, C, Ashley, EA, Auburn, S, Awandare, GA, Ba, H, Baraka, V, Barry, AE, Bejon, P, Bertin, GI, Boni, MF, Borrmann, S, Bousema, T, Branch, O, Bull, PC, Busby, GBJ, Chookajorn, T, Chotivanich, K, Claessens, A, Conway, D, Craig, A, D'Alessandro, U, Dama, S, Day, NP, Denis, B, Diakite, M, Djimdé, A, Dolecek, C, Dondorp, AM, Drakeley, C, Drury, E, Duffy, P, Echeverry, DF, Egwang, TG, Erko, B, Fairhurst, RM, Faiz, A, Fanello, CA, Fukuda, MM, Gamboa, D, Ghansah, A, Golassa, L, Goncalves, S, Hamilton, WL, Harrison, GLA, Hart, L, Henrichs, C, Hien, TT, Hill, CA, Hodgson, A, Hubbart, C, Imwong, M, Ishengoma, DS, Jackson, SA, Jacob, CG, Jeffery, B, Jeffreys, AE, Johnson, KJ, Jyothi, D, Kamaliddin, C, Kamau, E, Kekre, M, Kluczynski, K, Kochakarn, T, Konaté, A, Kwiatkowski, DP, Kyaw, MP, Lim, P, Lon, C, Loua, KM, Maïga-Ascofaré, O, Malangone, C, Manske, M, Marfurt, J, Marsh, K, Mayxay, M, Miles, A, Miotto, O, Mobegi, V, Mokuolu, OA, Montgomery, J, Mueller, I, Newton, PN, Nguyen, T, Nguyen, T-N, Noedl, H, Nosten, F, Noviyanti, R, Nzila, A, Ochola-Oyier, LI, Ocholla, H, Oduro, A, Omedo, I, Onyamboko, MA, Ouedraogo, J-B, Oyebola, K, Pearson, RD, Peshu, N, Phyo, AP, Plowe, CV, Price, RN, Pukrittayakamee, S, Randrianarivelojosia, M, Rayner, JC, Ringwald, P, Rockett, KA, Rowlands, K, Ruiz, L, Saunders, D, Shayo, A, Siba, P, Simpson, VJ, Stalker, J, Su, X-Z, Sutherland, C, Takala-Harrison, S, Tavul, L, Thathy, V, Tshefu, A, Verra, F, Vinetz, J, Wellems, TE, Wendler, J, White, NJ, Wright, I, Yavo, W, and Ye, H

Abstract

MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed. Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.

Published
2021

5. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

Author

Ahouidi, A., Ali, M, Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amato, R., Amenga-Etego, L., Andagalu, B., Anderson, T.J., Andrianaranjaka, V., Apinjoh, T., Ariani, C., Ashley, E.A., Auburn, S., Awandare, G.A., Ba, H., Baraka, V., Barry, A.E., Bejon, P., Bertin, G.I., Boni, M.F., Borrmann, S., Bousema, T., Branch, O., Bull, P.C., Busby, G.B.J., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D., Craig, A., D'Alessandro, U., Dama, S., Day, N.P., Denis, B., Diakite, M., Djimdé, A., Dolecek, C., Dondorp, A.M., Drakeley, C., Drury, E., Duffy, P., Echeverry, D.F., Egwang, T.G., Erko, B., Fairhurst, R.M., Faiz, A., Fanello, C.A., Fukuda, M.M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Hamilton, W.L., Harrison, G.L.A., Hart, L. 't, Henrichs, C., Hien, T.T., Hill, C.A., Hodgson, A., Hubbart, C., Imwong, M., Ishengoma, D.S., Jackson, S.A., Jacob, C.G., Jeffery, B., Jeffreys, A.E., Johnson, K.J., Jyothi, D., Kamaliddin, C., Kamau, E., Kekre, M., Kluczynski, K., Kochakarn, T., Konaté, A., Kwiatkowski, D.P., Kyaw, M.P., Lim, P., Lon, C., Loua, K.M., Maïga-Ascofaré, O., Malangone, C., Manske, M., Marfurt, J., Marsh, K., Mayxay, M., Miles, A., Miotto, O., Mobegi, V., Mokuolu, O.A., Montgomery, J., Mueller, I., Newton, P.N., Nguyen, T., Nguyen, T.N.D., Noedl, H., Nosten, F., Noviyanti, R., Nzila, A., Ochola-Oyier, L.I., Ahouidi, A., Ali, M, Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amato, R., Amenga-Etego, L., Andagalu, B., Anderson, T.J., Andrianaranjaka, V., Apinjoh, T., Ariani, C., Ashley, E.A., Auburn, S., Awandare, G.A., Ba, H., Baraka, V., Barry, A.E., Bejon, P., Bertin, G.I., Boni, M.F., Borrmann, S., Bousema, T., Branch, O., Bull, P.C., Busby, G.B.J., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D., Craig, A., D'Alessandro, U., Dama, S., Day, N.P., Denis, B., Diakite, M., Djimdé, A., Dolecek, C., Dondorp, A.M., Drakeley, C., Drury, E., Duffy, P., Echeverry, D.F., Egwang, T.G., Erko, B., Fairhurst, R.M., Faiz, A., Fanello, C.A., Fukuda, M.M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Hamilton, W.L., Harrison, G.L.A., Hart, L. 't, Henrichs, C., Hien, T.T., Hill, C.A., Hodgson, A., Hubbart, C., Imwong, M., Ishengoma, D.S., Jackson, S.A., Jacob, C.G., Jeffery, B., Jeffreys, A.E., Johnson, K.J., Jyothi, D., Kamaliddin, C., Kamau, E., Kekre, M., Kluczynski, K., Kochakarn, T., Konaté, A., Kwiatkowski, D.P., Kyaw, M.P., Lim, P., Lon, C., Loua, K.M., Maïga-Ascofaré, O., Malangone, C., Manske, M., Marfurt, J., Marsh, K., Mayxay, M., Miles, A., Miotto, O., Mobegi, V., Mokuolu, O.A., Montgomery, J., Mueller, I., Newton, P.N., Nguyen, T., Nguyen, T.N.D., Noedl, H., Nosten, F., Noviyanti, R., Nzila, A., and Ochola-Oyier, L.I.

Abstract

Contains fulltext : 238195.pdf (Publisher’s version ) (Open Access), MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed. Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.

Published
2021

6. An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

Author

Ahouidi, A., Ali, M, Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amato, R., Amenga-Etego, L., Andagalu, B., Anderson, T.J., Andrianaranjaka, V., Apinjoh, T., Ariani, C., Ashley, E.A., Auburn, S., Awandare, G.A., Ba, H., Baraka, V., Barry, A.E., Bejon, P., Bertin, G.I., Boni, M.F., Borrmann, S., Bousema, T., Branch, O., Bull, P.C., Busby, G.B.J., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D., Craig, A., D'Alessandro, U., Dama, S., Day, N.P., Denis, B., Diakite, M., Djimdé, A., Dolecek, C., Dondorp, A.M., Drakeley, C., Drury, E., Duffy, P., Echeverry, D.F., Egwang, T.G., Erko, B., Fairhurst, R.M., Faiz, A., Fanello, C.A., Fukuda, M.M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Hamilton, W.L., Harrison, G.L.A., Hart, L. 't, Henrichs, C., Hien, T.T., Hill, C.A., Hodgson, A., Hubbart, C., Imwong, M., Ishengoma, D.S., Jackson, S.A., Jacob, C.G., Jeffery, B., Jeffreys, A.E., Johnson, K.J., Jyothi, D., Kamaliddin, C., Kamau, E., Kekre, M., Kluczynski, K., Kochakarn, T., Konaté, A., Kwiatkowski, D.P., Kyaw, M.P., Lim, P., Lon, C., Loua, K.M., Maïga-Ascofaré, O., Malangone, C., Manske, M., Marfurt, J., Marsh, K., Mayxay, M., Miles, A., Miotto, O., Mobegi, V., Mokuolu, O.A., Montgomery, J., Mueller, I., Newton, P.N., Nguyen, T., Nguyen, T.N.D., Noedl, H., Nosten, F., Noviyanti, R., Nzila, A., Ochola-Oyier, L.I., Ahouidi, A., Ali, M, Almagro-Garcia, J., Amambua-Ngwa, A., Amaratunga, C., Amato, R., Amenga-Etego, L., Andagalu, B., Anderson, T.J., Andrianaranjaka, V., Apinjoh, T., Ariani, C., Ashley, E.A., Auburn, S., Awandare, G.A., Ba, H., Baraka, V., Barry, A.E., Bejon, P., Bertin, G.I., Boni, M.F., Borrmann, S., Bousema, T., Branch, O., Bull, P.C., Busby, G.B.J., Chookajorn, T., Chotivanich, K., Claessens, A., Conway, D., Craig, A., D'Alessandro, U., Dama, S., Day, N.P., Denis, B., Diakite, M., Djimdé, A., Dolecek, C., Dondorp, A.M., Drakeley, C., Drury, E., Duffy, P., Echeverry, D.F., Egwang, T.G., Erko, B., Fairhurst, R.M., Faiz, A., Fanello, C.A., Fukuda, M.M., Gamboa, D., Ghansah, A., Golassa, L., Goncalves, S., Hamilton, W.L., Harrison, G.L.A., Hart, L. 't, Henrichs, C., Hien, T.T., Hill, C.A., Hodgson, A., Hubbart, C., Imwong, M., Ishengoma, D.S., Jackson, S.A., Jacob, C.G., Jeffery, B., Jeffreys, A.E., Johnson, K.J., Jyothi, D., Kamaliddin, C., Kamau, E., Kekre, M., Kluczynski, K., Kochakarn, T., Konaté, A., Kwiatkowski, D.P., Kyaw, M.P., Lim, P., Lon, C., Loua, K.M., Maïga-Ascofaré, O., Malangone, C., Manske, M., Marfurt, J., Marsh, K., Mayxay, M., Miles, A., Miotto, O., Mobegi, V., Mokuolu, O.A., Montgomery, J., Mueller, I., Newton, P.N., Nguyen, T., Nguyen, T.N.D., Noedl, H., Nosten, F., Noviyanti, R., Nzila, A., and Ochola-Oyier, L.I.

Abstract

Contains fulltext : 238195.pdf (Publisher’s version ) (Open Access), MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed. Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination.

Published
2021

7. The effects of psychoeducational family intervention on coping strategies of relatives of patients with bipolar I disorder: results from a controlled, real-world, multicentric study

Author

Sampogna, G, Luciano, M, Del Vecchio, V, Malangone, C, De Rosa, C, Giallonardo, V, Borriello, G, Pocai, B, Savorani, M, Steardo Jr, L, Lampis, D, Veltro, F, Bartoli, F, Bardicchia, F, Moroni, A, Ciampini, G, Orlandi, E, Ferrari, S, Biondi, S, Iapichino, S, Pompili, E, Piselli, M, Tortorella, A, Carrà, G, Fiorillo, A, Moroni, AM, Sampogna, G, Luciano, M, Del Vecchio, V, Malangone, C, De Rosa, C, Giallonardo, V, Borriello, G, Pocai, B, Savorani, M, Steardo Jr, L, Lampis, D, Veltro, F, Bartoli, F, Bardicchia, F, Moroni, A, Ciampini, G, Orlandi, E, Ferrari, S, Biondi, S, Iapichino, S, Pompili, E, Piselli, M, Tortorella, A, Carrà, G, Fiorillo, A, and Moroni, AM

Abstract

Background: Psychoeducational family intervention (PFI) has been proven to be effective in improving the levels of family burden and patients’ personal functioning in schizophrenia and bipolar disorders (BDs). Less is known about the impact of PFI on relatives’ coping strategies in BD. Methods: A multicenter, controlled, outpatient trial funded by the Italian Ministry of Health and coordinated by the Department of Psychiatry of the University of Campania “Luigi Vanvitelli” has been conducted in patients with bipolar I disorder (BD-I) and their key relatives consecutively recruited in 11 randomly selected Italian community mental health centers. We aim to test the hypothesis that PFI improves problem-oriented coping strategies in relatives of BD-I patients compared to the Treatment As Usual (TAU) group. Results: The final sample was constituted of 123 patients and 139 relatives. At baseline assessment (T0), the vast majority of relatives already adopted problem-oriented coping strategies more frequently than the emotion-focused ones. At the end of the intervention, relatives receiving PFI reported a higher endorsement of adaptive coping strategies, such as “maintenance of social interests” (odds ratio [OR]=0.309, CI=0.04–0.57; p=0.023), “positive communication with the patient” (OR=0.295, CI=0.13–0.46; p=0.001), and “searching for information” (OR=0.443, CI=0.12–0.76; p=0.007), compared to TAU relatives, after controlling for several confounders. As regards the emotion-focused coping strategies, relatives receiving the experimental intervention less frequently reported to adopt “resignation” (OR=-0.380, CI=-0.68 to -0.08; p=0.014) and “coercion” (OR=-0.268, CI=-0.46 to -0.08; p=0.006) strategies, compared to TAU relatives. Conclusion: PFI is effective in improving the adaptive coping strategies of relatives of BD-I patients, but further studies are needed for evaluating the long-term benefits of this intervention.

Published
2018

8. The effects of psychoeducational family intervention on coping strategies of relatives of patients with bipolar I disorder: results from a controlled, real-world, multicentric study

Author

Sampogna, G, Luciano, M, Del Vecchio, V, Malangone, C, De Rosa, C, Giallonardo, V, Borriello, G, Pocai, B, Savorani, M, Steardo Jr, L, Lampis, D, Veltro, F, Bartoli, F, Bardicchia, F, Moroni, A, Ciampini, G, Orlandi, E, Ferrari, S, Biondi, S, Iapichino, S, Pompili, E, Piselli, M, Tortorella, A, Carrà, G, Fiorillo, A, Moroni, AM, Sampogna, G, Luciano, M, Del Vecchio, V, Malangone, C, De Rosa, C, Giallonardo, V, Borriello, G, Pocai, B, Savorani, M, Steardo Jr, L, Lampis, D, Veltro, F, Bartoli, F, Bardicchia, F, Moroni, A, Ciampini, G, Orlandi, E, Ferrari, S, Biondi, S, Iapichino, S, Pompili, E, Piselli, M, Tortorella, A, Carrà, G, Fiorillo, A, and Moroni, AM

Abstract

Background: Psychoeducational family intervention (PFI) has been proven to be effective in improving the levels of family burden and patients’ personal functioning in schizophrenia and bipolar disorders (BDs). Less is known about the impact of PFI on relatives’ coping strategies in BD. Methods: A multicenter, controlled, outpatient trial funded by the Italian Ministry of Health and coordinated by the Department of Psychiatry of the University of Campania “Luigi Vanvitelli” has been conducted in patients with bipolar I disorder (BD-I) and their key relatives consecutively recruited in 11 randomly selected Italian community mental health centers. We aim to test the hypothesis that PFI improves problem-oriented coping strategies in relatives of BD-I patients compared to the Treatment As Usual (TAU) group. Results: The final sample was constituted of 123 patients and 139 relatives. At baseline assessment (T0), the vast majority of relatives already adopted problem-oriented coping strategies more frequently than the emotion-focused ones. At the end of the intervention, relatives receiving PFI reported a higher endorsement of adaptive coping strategies, such as “maintenance of social interests” (odds ratio [OR]=0.309, CI=0.04–0.57; p=0.023), “positive communication with the patient” (OR=0.295, CI=0.13–0.46; p=0.001), and “searching for information” (OR=0.443, CI=0.12–0.76; p=0.007), compared to TAU relatives, after controlling for several confounders. As regards the emotion-focused coping strategies, relatives receiving the experimental intervention less frequently reported to adopt “resignation” (OR=-0.380, CI=-0.68 to -0.08; p=0.014) and “coercion” (OR=-0.268, CI=-0.46 to -0.08; p=0.006) strategies, compared to TAU relatives. Conclusion: PFI is effective in improving the adaptive coping strategies of relatives of BD-I patients, but further studies are needed for evaluating the long-term benefits of this intervention.

Published
2018

9. Genomic epidemiology of artemisinin resistant malaria

Author

Amato, R., Miotto, O., Woodrow, C.J., Almagro-Garcia, J., Sinha, I., Campino, S., Mead, D., Drury, E., Kekre, M., Sanders, M., Amambua-Ngwa, A., Amaratunga, C., Amenga-Etego, L., Andrianaranjaka, V., Apinjoh, T., Ashley, E., Auburn, S., Awandare, G.A., Baraka, V., Barry, Alyssa, Boni, M.F., Borrmann, S., Bousema, T., Branch, O., Bull, P.C., Chotivanich, K., Conway, D.J., Craig, A., Day, N.P., Djimdé, A., Dolecek, C., Dondorp, A.M., Drakeley, C., Duffy, P., Echeverry, D.F., Egwang, T.G., Fairhurst, R.M., Faiz, A., Fanello, C.I., Hien, T.T., Hodgson, A., Imwong, M., Ishengoma, D., Lim, P., Lon, C., Marfurt, J., Marsh, K., Mayxay, M., Michon, P., Mobegi, V., Mokuolu, O.A., Montgomery, J., Mueller, I., Kyaw, M.P., Newton, P.N., Nosten, F., Noviyanti, R., Nzila, A., Ocholla, H., Oduro, A., Onyamboko, M., Ouedraogo, J.B., Phyo, A.P.P., Plowe, C., Price, R.N., Pukrittayakamee, S., Randrianarivelojosia, M., Ringwald, P., Ruiz, L., Saunders, D., Shayo, A., Siba, P., Takala-Harrison, S., Thanh, T.N.N., Thathy, V., Verra, F., Wendler, J., White, N.J., Ye, H., Cornelius, V.J., Giacomantonio, R., Muddyman, D., Henrichs, C., Malangone, C., Jyothi, D., Pearson, R.D., Rayner, J.C., McVean, G., Rockett, K.A., Miles, A., Vauterin, P., Jeffery, B., Manske, M., Stalker, J., Macinnis, B., Kwiatkowski, D.P., Amato, R., Miotto, O., Woodrow, C.J., Almagro-Garcia, J., Sinha, I., Campino, S., Mead, D., Drury, E., Kekre, M., Sanders, M., Amambua-Ngwa, A., Amaratunga, C., Amenga-Etego, L., Andrianaranjaka, V., Apinjoh, T., Ashley, E., Auburn, S., Awandare, G.A., Baraka, V., Barry, Alyssa, Boni, M.F., Borrmann, S., Bousema, T., Branch, O., Bull, P.C., Chotivanich, K., Conway, D.J., Craig, A., Day, N.P., Djimdé, A., Dolecek, C., Dondorp, A.M., Drakeley, C., Duffy, P., Echeverry, D.F., Egwang, T.G., Fairhurst, R.M., Faiz, A., Fanello, C.I., Hien, T.T., Hodgson, A., Imwong, M., Ishengoma, D., Lim, P., Lon, C., Marfurt, J., Marsh, K., Mayxay, M., Michon, P., Mobegi, V., Mokuolu, O.A., Montgomery, J., Mueller, I., Kyaw, M.P., Newton, P.N., Nosten, F., Noviyanti, R., Nzila, A., Ocholla, H., Oduro, A., Onyamboko, M., Ouedraogo, J.B., Phyo, A.P.P., Plowe, C., Price, R.N., Pukrittayakamee, S., Randrianarivelojosia, M., Ringwald, P., Ruiz, L., Saunders, D., Shayo, A., Siba, P., Takala-Harrison, S., Thanh, T.N.N., Thathy, V., Verra, F., Wendler, J., White, N.J., Ye, H., Cornelius, V.J., Giacomantonio, R., Muddyman, D., Henrichs, C., Malangone, C., Jyothi, D., Pearson, R.D., Rayner, J.C., McVean, G., Rockett, K.A., Miles, A., Vauterin, P., Jeffery, B., Manske, M., Stalker, J., Macinnis, B., and Kwiatkowski, D.P.

Published
2016

10. Genomic epidemiology of artemisinin resistant malaria

Author

Amato, R, Miotto, O, Woodrow, CJ, Almagro-Garcia, J, Sinha, I, Campino, S, Mead, D, Drury, E, Kekre, M, Sanders, M, Amambua-Ngwa, A, Amaratunga, C, Amenga-Etego, L, Andrianaranjaka, V, Apinjoh, T, Ashley, E, Auburn, S, Awandare, GA, Baraka, V, Barry, A, Boni, MF, Borrmann, S, Bousema, T, Branch, O, Bull, PC, Chotivanich, K, Conway, DJ, Craig, A, Day, NP, Djimde, A, Dolecek, C, Dondorp, AM, Drakeley, C, Duffy, P, Echeverry, DF, Egwang, TG, Fairhurst, RM, Faiz, MA, Fanello, CI, Tran, TH, Hodgson, A, Imwong, M, Ishengoma, D, Lim, P, Lon, C, Marfurt, J, Marsh, K, Mayxay, M, Michon, P, Mobegi, V, Mokuolu, OA, Montgomery, J, Mueller, I, Kyaw, MP, Newton, PN, Nosten, F, Noviyanti, R, Nzila, A, Ocholla, H, Oduro, A, Onyamboko, M, Ouedraogo, J-B, Phyo, APP, Plowe, C, Price, RN, Pukrittayakamee, S, Randrianarivelojosia, M, Ringwald, P, Ruiz, L, Saunders, D, Shayo, A, Siba, P, Takala-Harrison, S, Thanh, T-NN, Thathy, V, Verra, F, Wendler, J, White, NJ, Ye, H, Cornelius, VJ, Giacomantonio, R, Muddyman, D, Henrichs, C, Malangone, C, Jyothi, D, Pearson, RD, Rayner, JC, McVean, G, Rockett, KA, Miles, A, Vauterin, P, Jeffery, B, Manske, M, Stalker, J, Maclnnis, B, Kwiatkowski, DP, Amato, R, Miotto, O, Woodrow, CJ, Almagro-Garcia, J, Sinha, I, Campino, S, Mead, D, Drury, E, Kekre, M, Sanders, M, Amambua-Ngwa, A, Amaratunga, C, Amenga-Etego, L, Andrianaranjaka, V, Apinjoh, T, Ashley, E, Auburn, S, Awandare, GA, Baraka, V, Barry, A, Boni, MF, Borrmann, S, Bousema, T, Branch, O, Bull, PC, Chotivanich, K, Conway, DJ, Craig, A, Day, NP, Djimde, A, Dolecek, C, Dondorp, AM, Drakeley, C, Duffy, P, Echeverry, DF, Egwang, TG, Fairhurst, RM, Faiz, MA, Fanello, CI, Tran, TH, Hodgson, A, Imwong, M, Ishengoma, D, Lim, P, Lon, C, Marfurt, J, Marsh, K, Mayxay, M, Michon, P, Mobegi, V, Mokuolu, OA, Montgomery, J, Mueller, I, Kyaw, MP, Newton, PN, Nosten, F, Noviyanti, R, Nzila, A, Ocholla, H, Oduro, A, Onyamboko, M, Ouedraogo, J-B, Phyo, APP, Plowe, C, Price, RN, Pukrittayakamee, S, Randrianarivelojosia, M, Ringwald, P, Ruiz, L, Saunders, D, Shayo, A, Siba, P, Takala-Harrison, S, Thanh, T-NN, Thathy, V, Verra, F, Wendler, J, White, NJ, Ye, H, Cornelius, VJ, Giacomantonio, R, Muddyman, D, Henrichs, C, Malangone, C, Jyothi, D, Pearson, RD, Rayner, JC, McVean, G, Rockett, KA, Miles, A, Vauterin, P, Jeffery, B, Manske, M, Stalker, J, Maclnnis, B, and Kwiatkowski, DP

Abstract

The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of variations that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelch13 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions.

Published
2016

11. Feasibility of a psychoeducational family intervention for people with bipolar i disorder and their relatives: Results from an Italian real-world multicentre study

Author

Fiorillo, A, Del Vecchio, V, Luciano, M, Sampogna, G, Sbordone, D, Catapano, F, DE ROSA, S, Malangone, C, Tortorella, A, Veltro, F, Nicolò, G, Piselli, M, Bardicchia, F, Ciampini, G, Lampis, D, Moroni, A, Bassi, M, Iapichino, S, Biondi, S, Graziani, A, Orlandi, E, Starace, F, Baronessa, C, Carra', G, Maj, M, Maj, M., DE ROSA, STEFANIA ROSA CARLA, BARONESSA, CRISTINA, CARRA', GIUSEPPE, Fiorillo, A, Del Vecchio, V, Luciano, M, Sampogna, G, Sbordone, D, Catapano, F, DE ROSA, S, Malangone, C, Tortorella, A, Veltro, F, Nicolò, G, Piselli, M, Bardicchia, F, Ciampini, G, Lampis, D, Moroni, A, Bassi, M, Iapichino, S, Biondi, S, Graziani, A, Orlandi, E, Starace, F, Baronessa, C, Carra', G, Maj, M, Maj, M., DE ROSA, STEFANIA ROSA CARLA, BARONESSA, CRISTINA, and CARRA', GIUSEPPE

Abstract

Background Despite several guidelines recommend the use of psychoeducational family interventions (PFIs) as add-on in the treatment of patients with bipolar I disorder, their implementation on a large scale remains limited. The aim of the present study is to identify obstacles for the feasibility of PFIs in routine care. Methods This was a multicentre, real-world, controlled, outpatient trial, carried out in 11 randomly recruited Italian mental health centres. Two mental health professionals from each center attended a modular training course on PFI and provided the intervention. Difficulties and benefits experienced by mental health professionals in implementing the intervention were assessed through the Family Intervention Schedule (FIS-R), which was administered six times. Results Sixteen out of the 22 recruited professionals completed the training and administered the PFI to 70 patients with bipolar I disorder and their relatives. The retention rate of families receiving the intervention was 93%. Mental health professionals reported high levels of organizational difficulties, several benefits in their daily clinical work and low levels of intervention-related difficulties. The most important organizational obstacles were related to the need to integrate the intervention with other work responsibilities and to the lack of time to carry out the intervention. These difficulties did not decrease over time. Intervention-related difficulties were rated as less problematic since the first time assessment and tended to improve over time. Limitations Low number of recruited professionals; use of a not previously validated assessment instrument. Conclusions PFIs are feasible in routine care for the treatment of patients with bipolar I disorder and their relatives, and main obstacles are related to the organization/structure of mental health centres, and not to the characteristics of the intervention itself.

Published
2016

12. Efficacy of psychoeducational family intervention for bipolar i disorder: A controlled, multicentric, real-world study

Author

Fiorillo, A, Del Vecchio, V, Luciano, M, Sampogna, G, De Rosa, C, Malangone, C, Volpe, U, Bardicchia, F, Ciampini, G, Crocamo, C, Iapichino, S, Lampis, D, Moroni, A, Orlandi, E, Piselli, M, Pompili, E, Veltro, F, Carra', G, Maj, M, CROCAMO, CRISTINA, CARRA', GIUSEPPE, Maj, M., Fiorillo, A, Del Vecchio, V, Luciano, M, Sampogna, G, De Rosa, C, Malangone, C, Volpe, U, Bardicchia, F, Ciampini, G, Crocamo, C, Iapichino, S, Lampis, D, Moroni, A, Orlandi, E, Piselli, M, Pompili, E, Veltro, F, Carra', G, Maj, M, CROCAMO, CRISTINA, CARRA', GIUSEPPE, and Maj, M.

Abstract

Background This study assessed the efficacy of the Falloon model of psychoeducational family intervention (PFI), originally developed for schizophrenia management and adapted to bipolar I disorder. The efficacy of the intervention was evaluated in terms of improvement of patients' social functioning and reduction of family burden.Methods This was a multicentre, real-world, controlled, outpatient trial carried out in 11 randomly recruited Italian mental health centres. Enroled patients and key-relatives were consecutively allocated either to receive PFI and Treatment As Usual (TAU) or to a waiting list receiving TAU alone. The efficacy of the intervention was evaluated in terms of improvement in patients' social functioning (primary outcome) and reduction of family burden (secondary outcome).Results Of the 137 recruited families, 70 were allocated to the experimental group and 67 to the control group. At the end of the intervention, significant improvements in patients' social functioning and in relatives' burden were found in the treated group compared to TAU. This effect of the intervention remained also after controlling for several confounding patient's socio-demographic and clinical factors. The experimental intervention had an impact also on other outcome measures, such as patients' clinical status and personal burden.Limitations Lack of an active control group.Conclusions The results of this study clearly show that the psychoeducational family intervention according to the Falloon model is effective in improving the social outcome of patients with bipolar I disorder.

Published
2015

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