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2. SPECIES ASSIGNATION OF LEISHMANIA FROM HUMAN AND CANINE AMERICAN TEGUMENTARY LEISHMANIASIS CASES BY MULTILOCUS ENZYME ELECTROPHORESIS IN NORTH ARGENTINA

Author

Marco, Jorge D., Barroso, Paola A., Calvopiña, Manuel, Kumazawa, Hideo, Furuya, Masato, Korenaga, Masataka, Cajal, Silvana P., Mora, María C., Rea, María M. J., Borda, C. Edgardo, Basombrío, Miguel A., Taranto, Néstor J., Hashiguchi, Yoshihisa, Marco, Jorge D., Barroso, Paola A., Calvopiña, Manuel, Kumazawa, Hideo, Furuya, Masato, Korenaga, Masataka, Cajal, Silvana P., Mora, María C., Rea, María M. J., Borda, C. Edgardo, Basombrío, Miguel A., Taranto, Néstor J., and Hashiguchi, Yoshihisa

Published
2018

3. MULTILOCUS ENZYME ELECTROPHORESIS AND CYTOCHROME B GENE SEQUENCING–BASED IDENTIFICATION OF LEISHMANIA ISOLATES FROM DIFFERENT FOCI OF CUTANEOUS LEISHMANIASIS IN PAKISTAN

Author

Marco, Jorge D., Bhutto, Abdul M., Soomro, Farooq R., Baloch, Javed H., Barroso, Paola A., Kato, Hirotomo, Uezato, Hiroshi, Katakura, Ken, Korenaga, Masataka, Nonaka, Shigeo, Hashiguchi, Yoshihisa, Marco, Jorge D., Bhutto, Abdul M., Soomro, Farooq R., Baloch, Javed H., Barroso, Paola A., Kato, Hirotomo, Uezato, Hiroshi, Katakura, Ken, Korenaga, Masataka, Nonaka, Shigeo, and Hashiguchi, Yoshihisa

Published
2018

5. DETECTION AND IDENTIFICATION OF LEISHMANIA SPECIES WITHIN NATURALLY INFECTED SAND FLIES IN THE ANDEAN AREAS OF ECUADOR BY A POLYMERASE CHAIN REACTION

Author

Kato, Hirotomo, Uezato, Hiroshi, Katakura, Ken, Calvopiña, Manuel, Marco, Jorge D., Barroso, Paola A., Gomez, Eduardo A., Mimori, Tatsuyuki, Korenaga, Masataka, Iwata, Hiroyuki, Nonaka, Shigeo, Hashiguchi, Yoshihisa, Kato, Hirotomo, Uezato, Hiroshi, Katakura, Ken, Calvopiña, Manuel, Marco, Jorge D., Barroso, Paola A., Gomez, Eduardo A., Mimori, Tatsuyuki, Korenaga, Masataka, Iwata, Hiroyuki, Nonaka, Shigeo, and Hashiguchi, Yoshihisa

Published
2018

6. Leishmania isoenzyme polymorphisms in Ecuador: Relationships with geographic distribution and clinical presentation

Author

Calvopina, Manuel, Armijos, Rodrigo X., Marco, Jorge D., Uezato, Hiroshi, Kato, Hirotomo, Gomez, Eduardo A., Korenaga, Masataka, Barroso, Paola A., Mimori, Tatsuyuki, Cooper, Philip J., Nonaka, Shigeo, Hashiguchi, Yoshihisa, Calvopina, Manuel, Armijos, Rodrigo X., Marco, Jorge D., Uezato, Hiroshi, Kato, Hirotomo, Gomez, Eduardo A., Korenaga, Masataka, Barroso, Paola A., Mimori, Tatsuyuki, Cooper, Philip J., Nonaka, Shigeo, and Hashiguchi, Yoshihisa

Published
2018

7. ARE CYTOCHROME B GENE SEQUENCING AND POLYMORPHISM-SPECIFIC POLYMERASE CHAIN REACTION AS RELIABLE AS MULTILOCUS ENZYME ELECTROPHORESIS FOR IDENTIFYING LEISHMANIA SPP. FROM ARGENTINA?

Author

Marco, Jorge D., Uezato, Hiroshi, Mimori, Tatsuyuki, Barroso, Paola A., Korenaga, Masataka, Nonaka, Shigeo, Basombrío, Miguel A., Taranto, Néstor J., Hashiguchi, Yoshihisa, Marco, Jorge D., Uezato, Hiroshi, Mimori, Tatsuyuki, Barroso, Paola A., Korenaga, Masataka, Nonaka, Shigeo, Basombrío, Miguel A., Taranto, Néstor J., and Hashiguchi, Yoshihisa

Published
2018

8. Next-generation ELISA diagnostic assay for Chagas Disease based on the combination of short peptidic epitopes

Author

Mucci, Juan, Carmona, Santiago J., Volcovich, Romina, Altcheh, Jaime, Bracamonte, Estefanisa, Marco, Jorge D., Nielsen, Morten, Buscaglia, Carlos A., Aguero, Fernan, Mucci, Juan, Carmona, Santiago J., Volcovich, Romina, Altcheh, Jaime, Bracamonte, Estefanisa, Marco, Jorge D., Nielsen, Morten, Buscaglia, Carlos A., and Aguero, Fernan

Abstract

Chagas Disease, caused by the protozoan Trypanosoma cruzi, is a major health and economic problem in Latin America for which no vaccine or appropriate drugs for large-scale public health interventions are yet available. Accurate diagnosis is essential for the early identification and follow up of vector-borne cases and to prevent transmission of the disease by way of blood transfusions and organ transplantation. Diagnosis is routinely performed using serological methods, some of which require the production of parasite lysates, parasite antigenic fractions or purified recombinant antigens. Although available serological tests give satisfactory results, the production of reliable reagents remains laborious and expensive. Short peptides spanning linear B-cell epitopes have proven ideal serodiagnostic reagents in a wide range of diseases. Recently, we have conducted a large-scale screening of T. cruzi linear B-cell epitopes using high-density peptide chips, leading to the identification of several hundred novel sequence signatures associated to chronic Chagas Disease. Here, we performed a serological assessment of 27 selected epitopes and of their use in a novel multipeptide-based diagnostic method. A combination of 7 of these peptides were finally evaluated in ELISA format against a panel of 199 sera samples (Chagas-positive and negative, including sera from Leishmaniasis-positive subjects). The multipeptide formulation displayed a high diagnostic performance, with a sensitivity of 96.3% and a specificity of 99.15%. Therefore, the use of synthetic peptides as diagnostic tools are an attractive alternative in Chagas' disease diagnosis.

Published
2017

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