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BACKGROUND: Short-chain fatty acids (SCFAs) produced by the gut microbiota have beneficial anti-inflammatory and gut homeostasis effects and prevent type 1 diabetes (T1D) in mice. Reduced SCFA production indicates a loss of beneficial bacteria, commonly associated with chronic autoimmune and inflammatory diseases, including T1D and type 2 diabetes. Here, we addressed whether a metabolite-based dietary supplement has an impact on humans with T1D. We conducted a single-arm pilot-and-feasibility trial with high-amylose maize-resistant starch modified with acetate and butyrate (HAMSAB) to assess safety, while monitoring changes in the gut microbiota in alignment with modulation of the immune system status. RESULTS: HAMSAB supplement was administered for 6 weeks with follow-up at 12 weeks in adults with long-standing T1D. Increased concentrations of SCFA acetate, propionate, and butyrate in stools and plasma were in concert with a shift in the composition and function of the gut microbiota. While glucose control and insulin requirements did not change, subjects with the highest SCFA concentrations exhibited the best glycemic control. Bifidobacterium longum, Bifidobacterium adolescentis, and vitamin B7 production correlated with lower HbA1c and basal insulin requirements. Circulating B and T cells developed a more regulatory phenotype post-intervention. CONCLUSION: Changes in gut microbiota composition, function, and immune profile following 6 weeks of HAMSAB supplementation were associated with increased SCFAs in stools and plasma. The persistence of these effects suggests that targeting dietary SCFAs may be a mechanism to alter immune profiles, promote immune tolerance, and improve glycemic control for the treatment of T1D. TRIAL REGISTRATION: ACTRN12618001391268. Registered 20 August 2018, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=375792 Video Abstract.

One of the foremost objectives of statistical mechanics is the description of the thermodynamic properties of quantum gases. Despite the great importance of this topic, such achievement is still lacking in the case of non-Hermitian quantum gases. Here, we investigate the properties of bosonic and fermionic non-Hermitian systems at finite temperatures. We show that non-Hermitian systems exhibit oscillations both in temperature and imaginary time. As such, they can be a possible platform to realize an imaginary time crystal (iTC) phase. The Hatano–Nelson model is identified as a simple lattice model to reveal this effect. In addition, we show that the conditions for the iTC to be manifest are the same as the conditions for the presence of disorder points, where the correlation functions show oscillating behavior. This analysis makes clear that our realization of an iTC is effectively a way to filter one specific Matsubara mode. In this realization, the Matsubara frequency, which usually appears as a mathematical tool to compute correlation functions at finite temperatures, can be measured experimentally.

Background: The coronavirus pandemic had a major impact in Italy. The Italian health system’s re-organization to face the emergency may have led to significant consequences especially in the diagnosis and treatment of malignancies. This study aimed to assess the impact of the pandemic in the diagnosis and treatment of gastric cancer in nine Gruppo Italiano RIcerca Cancro Gastrico (GIRCG) centers. Methods: All patients assessed for gastric adenocarcinoma at nine GIRCG centers between January 2019 and November 2020 were included. Patients were grouped according to the date of “patient 1’s” diagnosis in Italy: preCOVID versus COVID. Clinico-pathological and outcome differences between the two groups were analyzed. Results: A total of 632 patients were included in the analysis (205 in the COVID group). The cT4 weighted ratios were higher in 2020 from April to September, with the greatest differences in May, August and September. The cM+ weighted ratio was significantly higher in July 2020. The mean number of gastrectomies had the greatest reduction in March and May 2020 compared with 2019. The median times from diagnosis to chemotherapy, to complete diagnostic work-up or to operation were longer in 2019. The median time from the end of chemotherapy to surgery was 17 days longer in the preCOVID group. Conclusions: A greater number of advanced or metastatic cases were diagnosed after the spread of SARS-CoV-2 infection, especially after the “full lockdown” periods. During the pandemic, once gastric cancer patients were referred to one of the centers, a shorter time to complete the diagnostic work-up or to address them to the best treatment option was required.

The current report provides a review of European marine exhalative deposits based on their metallogenic setting. Settings include mid ocean ridge spreading sites, sites related to intra-plate hotspots, and arc/back-arc spreading sites.

The current report provides a review of European marine exhalative deposits based on their metallogenic setting. Settings include mid ocean ridge spreading sites, sites related to intra-plate hotspots, and arc/back-arc spreading sites.

The current report provides a review of European marine exhalative deposits based on their metallogenic setting. Settings include mid ocean ridge spreading sites, sites related to intra-plate hotspots, and arc/back-arc spreading sites.

The current report provides a review of European marine exhalative deposits based on their metallogenic setting. Settings include mid ocean ridge spreading sites, sites related to intra-plate hotspots, and arc/back-arc spreading sites.

In this work, we integrate five case studies harboring vulnerable deep-sea benthic habitats in different geological settings from mid latitude NE Atlantic Ocean (24–42° N). Data and images of specific deep-sea habitats were acquired with Remoted Operated Vehicle (ROV) sensors (temperature, salinity, potential density, O2, CO2, and CH4). Besides documenting some key vulnerable deep-sea habitats, this study shows that the distribution of some deep-sea coral aggregations (including scleractinians, gorgonians, and antipatharians), deep-sea sponge aggregations and other deep-sea habitats are influenced by water masses’ properties. Our data support that the distribution of scleractinian reefs and aggregations of other deep-sea corals, from subtropical to north Atlantic could be dependent of the latitudinal extents of the Antarctic Intermediate Waters (AAIW) and the Mediterranean Outflow Waters (MOW). Otherwise, the distribution of some vulnerable deep-sea habitats is influenced, at the local scale, by active hydrocarbon seeps (Gulf of Cádiz) and hydrothermal vents (El Hierro, Canary Island). The co-occurrence of deep-sea corals and chemosynthesis-based communities has been identified in methane seeps of the Gulf of Cádiz. Extensive beds of living deep-sea mussels (Bathymodiolus mauritanicus) and other chemosymbiotic bivalves occur closely to deep-sea coral aggregations (e.g., gorgonians, black corals) that colonize methane-derived authigenic carbonates.

Recently the renormalization of the band gap $m$, in both WSe$_2$ and MoS$_2$, has been experimentally measured as a function of the carrier concentration $n$. The main result establishes a decreasing of hundreds of meV, in comparison with the bare band gap, as the carrier concentration increases. These materials are known as transition metal dichalcogenides and their low-energy excitations are, approximately, described by the massive Dirac equation. Using Pseudo Quantum Electrodynamics (PQED) to describe the electromagnetic interaction between these quasiparticles and from renormalization group analysis, we obtain that the renormalized mass describes the band gap renormalization with a function given by $m(n)/m_0=(n/n_0)^{C_\lambda/2}$, where $m_0=m(n_0)$ and $C_\lambda$ is a function of the coupling constant $\lambda$. We compare our theoretical results with the experimental findings for WSe$_2$ and MoS$_2$, and we conclude that our approach is in agreement with these experimental results for reasonable values of $\lambda$. In addition we introduced a Gross-Neveu (GN) interaction which could simulate an disorder/impurity-like microscopic interaction. In this case, we show that there exists a critical coupling constant, namely, $\lambda_c \approx 0,66$ in which the beta function of the mass vanishes, providing a stable fixed point in the ultraviolet limit. For $\lambda>\lambda_c$, the renormalized mass decreases while for $\lambda<\lambda_c$ it increases with the carrier concentration., Comment: 10 pages, 7 figures

Through a multicenter study, we collected seven cases of gastric plexiform fibromyxoma including four females and three males, 21 to 79 y old (46.1 ± 10.1). All cases showed a unilocular lesion measuring 0.3 to 17 cm (5.3 ± 2.4), arising from antrum (5/7) or body (2/7). Six of the seven cases had intraoperative frozen sections and/or endoscopic ultrasound fine needle aspiration (EUS-FNA), and all of them were preoperatively or intraoperatively diagnosed as gastrointestinal stromal tumor (GIST). EUS-FNA material showed markedly elongated spindle cells with streaming oval to elongated nuclei with rounded ends. Histologically, the tumors exhibited a plexiform growth pattern and were composed of a rich myxoid stroma and cytologically bland uniform spindle cells without mitotic figures, with the exception of one case which displayed nuclear pleomorphism and increased mitosis. Immunostains showed the tumor cells to be focally positive for SMA (6/6), focally and weakly positive for desmin (3/6) and caldesmon (2/3), negative for CD117 (0/7), CD34 (0/7), DOG1 (0/4), and S100 (0/5). No mutations were identified on Next-Generation Sequencing test, and no loss of SDHB immunoreactivity was identified in the tumor with nuclear pleomorphism. One case was treated with Gleevec because of the initial diagnosis of GIST. All patients had a follow-up for up to 11 y, with no tumor recurrence or metastasis reported. Our results suggest that gastric plexiform fibromyxoma is rare and may be underrecognized and misinterpreted as GIST during intraoperative frozen section or preoperative EUS-FNA diagnosis without immunostains leading to inappropriate treatment.

The recent discovery of two-dimensional Dirac materials, such as graphene and transition-metaldichalcogenides, has raised questions about the treatment of hybrid systems, in which electrons moving in a two-dimensional plane interact via virtual photons from the three-dimensional space. In this case, a projected non-local theory, known as Pseudo-QED, or reduced QED, has shown to provide a correct framework for describing the interactions displayed by these systems. In a related situation, in planar materials exhibiting a superconducting phase, the electromagnetic field has a typical exponential decay that is interpreted as the photons having an effective mass, as a consequence of the Anderson-Higgs mechanism. Here, we use an analogous projection to that used to obtain the pseudo-QED to derive a Pseudo-Proca equivalent model. In terms of this model, we unveil the main effects of attributing a mass to the photons and to the quasi-relativistic electrons. The one-loop radiative corrections to the electron mass, to the photon and to the electron-photon vertex are computed. We calculate the quantum corrections to the electron g-factor and show that it smoothly goes to zero in the limit when the photon mass is much larger than the electron mass. In addition, we correct the results obtained for graphene within Pseudo-QED in the limit when the photon mass vanishes.

Pseudo-Quantum Electrodynamics (PQED) provides an excellent description of the interaction between charged particles confined to a plane. When we couple pseudo-gauge field with a bosonic matter field, we obtain the so-called Scalar Pseudo-Quantum Electrodynamics (SPQED). In this work, we make a perturbative analysis of SPQED via Feynman diagrams. We compute the one loop Green functions: bosonic field self-energy, electromagnetic field self-energy, and vertex corrections. Finally, we consider the non-relativistic interaction potential between two bosonic particles. We compute the radiative corrections to the usual Coulomb potential and comment on the analogies and the differences with the fermionic case.

Maternal immune dysregulation seems to affect fetal or postnatal immune development. Preeclampsia is a pregnancy-associated disorder with an immune basis and is linked to atopic disorders in offspring. Here we show reduction of fetal thymic size, altered thymic architecture and reduced fetal thymic regulatory T (Treg) cell output in preeclamptic pregnancies, which persists up to 4 years of age in human offspring. In germ-free mice, fetal thymic CD4+ T cell and Treg cell development are compromised, but rescued by maternal supplementation with the intestinal bacterial metabolite short chain fatty acid (SCFA) acetate, which induces upregulation of the autoimmune regulator (AIRE), known to contribute to Treg cell generation. In our human cohorts, low maternal serum acetate is associated with subsequent preeclampsia, and correlates with serum acetate in the fetus. These findings suggest a potential role of acetate in the pathogenesis of preeclampsia and immune development in offspring.

Through a multicenter study, we collected seven cases of gastric plexiform fibromyxoma including four females and three males, 21 to 79 y old (46.1 ± 10.1). All cases showed a unilocular lesion measuring 0.3 to 17 cm (5.3 ± 2.4), arising from antrum (5/7) or body (2/7). Six of the seven cases had intraoperative frozen sections and/or endoscopic ultrasound fine needle aspiration (EUS-FNA), and all of them were preoperatively or intraoperatively diagnosed as gastrointestinal stromal tumor (GIST). EUS-FNA material showed markedly elongated spindle cells with streaming oval to elongated nuclei with rounded ends. Histologically, the tumors exhibited a plexiform growth pattern and were composed of a rich myxoid stroma and cytologically bland uniform spindle cells without mitotic figures, with the exception of one case which displayed nuclear pleomorphism and increased mitosis. Immunostains showed the tumor cells to be focally positive for SMA (6/6), focally and weakly positive for desmin (3/6) and caldesmon (2/3), negative for CD117 (0/7), CD34 (0/7), DOG1 (0/4), and S100 (0/5). No mutations were identified on Next-Generation Sequencing test, and no loss of SDHB immunoreactivity was identified in the tumor with nuclear pleomorphism. One case was treated with Gleevec because of the initial diagnosis of GIST. All patients had a follow-up for up to 11 y, with no tumor recurrence or metastasis reported. Our results suggest that gastric plexiform fibromyxoma is rare and may be underrecognized and misinterpreted as GIST during intraoperative frozen section or preoperative EUS-FNA diagnosis without immunostains leading to inappropriate treatment.

The recent discovery of two-dimensional Dirac materials, such as graphene and transition-metaldichalcogenides, has raised questions about the treatment of hybrid systems, in which electrons moving in a two-dimensional plane interact via virtual photons from the three-dimensional space. In this case, a projected non-local theory, known as Pseudo-QED, or reduced QED, has shown to provide a correct framework for describing the interactions displayed by these systems. In a related situation, in planar materials exhibiting a superconducting phase, the electromagnetic field has a typical exponential decay that is interpreted as the photons having an effective mass, as a consequence of the Anderson-Higgs mechanism. Here, we use an analogous projection to that used to obtain the pseudo-QED to derive a Pseudo-Proca equivalent model. In terms of this model, we unveil the main effects of attributing a mass to the photons and to the quasi-relativistic electrons. The one-loop radiative corrections to the electron mass, to the photon and to the electron-photon vertex are computed. We calculate the quantum corrections to the electron g-factor and show that it smoothly goes to zero in the limit when the photon mass is much larger than the electron mass. In addition, we correct the results obtained for graphene within Pseudo-QED in the limit when the photon mass vanishes.

Quantum electrodynamics (QED) of electrons confined in a plane and that yet can undergo interactions mediated by an unconstrained photon has been described by the so-called {\it pseudo-QED} (PQED), the (2+1)-dimensional version of the equivalent dimensionally reduced original QED. In this work, we show that PQED with a nonlocal Chern-Simons term is dual to the Chern-Simons Higgs model at the quantum level. We apply the path-integral formalism in the dualization of the Chern-Simons Higgs model to first describe the interaction between quantum vortex particle excitations in the dual model. This interaction is explicitly shown to be in the form of a Bessel-like type of potential in the static limit. This result {\it per se} opens exciting possibilities for investigating topological states of matter generated by interactions, since the main difference between our new model and the PQED is the presence of a nonlocal Chern-Simons action. Indeed, the dual transformation yields an unexpected square root of the d'Alembertian operator, namely, $(\sqrt{-\Box})^{-1}$ multiplied by the well-known Chern-Simons action. Despite the nonlocality, the resulting model is still gauge invariant and preserves the unitarity, as we explicitly prove. {}Finally, when coupling the resulting model to Dirac fermions, we then show that pairs of bounded electrons are expected to appear, with a typical distance between the particles being inversely proportional to the topologically generated mass for the gauge field in the dual model., Comment: 7 pages. Replaced with version matching published one in the Phys. Lett. B

We derive an effective two-dimensional low-energy theory for thin superconducting films coupled to a three-dimensional fluctuating electromagnetic field. Using this theory we discuss plasma oscillations, interactions between charges and vortices and extract the energy of a vortex. Having found that the effective theory properly describes the long-distance physics, we then use it to investigate to what extent the superconducting film is a topologically ordered phase of matter., QC 20180920

We derive an effective two-dimensional low-energy theory for thin superconducting films coupled to a three-dimensional fluctuating electromagnetic field. Using this theory we discuss plasma oscillations, interactions between charges and vortices and extract the energy of a vortex. Having found that the effective theory properly describes the long-distance physics, we then use it to investigate to what extent the superconducting film is a topologically ordered phase of matter.

We derive an effective two-dimensional low-energy theory for thin superconducting films coupled to a three-dimensional fluctuating electromagnetic field. Using this theory we discuss plasma oscillations, interactions between charges and vortices and extract the energy of a vortex. Having found that the effective theory properly describes the long-distance physics, we then use it to investigate to what extent the superconducting film is a topologically ordered phase of matter.

We derive two versions of an effective model to describe dynamical effects of the Yukawa interaction among Dirac electrons in the plane. Such short-range interaction is obtained by introducing a mass term for the intermediate particle, which may be either scalar or an abelian gauge field, both of them in (3+1) dimensions. Thereafter, we consider that the matter field propagates only in (2+1) dimensions, whereas the bosonic field is free to propagate out of the plane. Within these assumptions, we apply a mechanism for dimensional reduction, which yields an effective model in (2+1) dimensions. In particular, for the gauge-field case, we use the Stueckelberg mechanism in order to preserve gauge invariance. We refer to this version as nonlocal-Proca quantum electrodynamics (NPQED). For both scalar and gauge cases, the effective models reproduce the usual $e^{-m r}/r$ Yukawa interaction in the static limit. By means of perturbation theory at one loop, we calculate the mass renormalization of the Dirac field. Our model is a generalization of Pseudoquantum electrodynamics (PQED), which is a gauge-field model that provides a Coulomb interaction for two-dimensional electrons. Possibilities of application to Fermi-Bose mixtures in mixed dimensions, using cold atoms, are briefly discussed., Comment: 8 pages, 2 figures

We derive an effective two-dimensional low-energy theory for thin superconducting films coupled to a three-dimensional fluctuating electromagnetic field. Using this theory we discuss plasma oscil- lations, interactions between charges and vortices and extract the energy of a vortex. Having found that the effective theory properly describes the long distance physics, we then use it to investigate to what extent the superconducting film is a topologically ordered phase of matter., Comment: Published, 13 pages, 1 figure

A polymorphism within the serotonin transporter gene (SERTPR) has been repeatedly associated to mood disorders and response to SSRIs treatment. Recent evidence suggested that influence of genetic effect of SERTPR might be modulated by stress, particularly as regard the development of anxious-depressive symptoms. Nevertheless, there is no information about the role of stressors as potential modulator of SERTPR effects on depressive outcome during pharmacological treatment. In a sample of 159 mood disorder patients treated with fluvoxamine, we found stressors; preceding the onset of the illness significantly influencing the genetic effect exerted by SERTPR on response after 6 weeks of treatment. This preliminary finding supports the idea of complex interaction between biological and environmental factors underlying the efficacy of biological treatments, other than liability for mood disorders. Nevertheless, many limitations characterize the present investigation and well-funded studies on larger samples are required. (C) 2008 Elsevier B.V. and ECNP. All rights reserved

It is well established that stress is a risk factor for onset of mood disorders. Emerging evidence suggests that genetic vulnerability may also moderate individual responsiveness to stress. The most compelling evidence regards the polymorphism within the promoter region of the serotonin transporter gene (SERTPR), which has been reported to moderate the risk for depression, in conjunction with life stressors. In the present paper we analysed SERTPR in the onset of mood disorders, along with adverse life events, and other candidate genes: the serotonin receptor 1A (5-HT1A), the dopamine receptor D4 (DRD4) and the catechol-O-methyltransferase (COMT). The sample was composed of 686 Italian subjects, affected by major depression and bipolar disorder. Patients were asked to report about life stressors within the year preceding onset of their first mood-disorder episode and genotyped. A 'case-only' design was employed to investigate the interaction between genes and stressors. COMT was associated with depression following exposure to stressors (X-2=13.05, d.f.=2, p=0.0015) and SERTPR also showed a positive association (X-2 = 6.70, d.f. = 2, p = 0.035), mainly among women and among major depressives. The interaction between COMT and SERTPR was also significant (p = 0.0005). In our retrospective study SERTPR is hypothesized to lead to the onset of major depression via its influence on reaction to adversities, particularly in females. Moreover, COMT was risk factor for onset of both major depression and bipolar disorder, in conjunction with adversities.

The electron, discovered by Thomson by the end of the nineteenth century, was the first experimentally observed particle. The Weyl fermion, though theoretically predicted since a long time, was observed in a condensed matter environment in an experiment reported only a few weeks ago. Is there any linking thread connecting the first and the last observed fermion (quasi)particles? The answer is positive. By generalizing the method known as bosonization, the first time in its full complete form, for a spacetime with 3+1 dimensions, we are able to show that both electrons and Weyl fermions can be expressed in terms of the same boson field, namely the Kalb-Ramond anti-symmetric tensor gauge field. The bosonized form of the Weyl chiral currents lead to the angle-dependent magneto-conductance behavior observed in these systems., Comment: 5 pages

We use the Schwinger-Dyson equations in the presence of a thermal bath, in order to study chiral symmetry breaking in a system of massless Dirac fermions interacting through pseudo quantum electrodynamics (PQED3), in (2+1) dimensions. We show that there is a critical temperature $T_c$, below which chiral symmetry is broken, and a corresponding mass gap is dynamically generated, provided the coupling is above a certain, temperature dependent, critical value $\alpha_c$. The ratio between the energy gap and the critical temperature for this model is estimated to be $2 \pi$. These results are confirmed by analytical and numerical investigations of the Schwinger-Dyson equation for the electron. In addition, we calculate the first finite-temperature corrections to the static Coulomb interaction. The relevance of this result in the realm of condensed matter systems, like graphene, is briefly discussed., Comment: 10 pages and 4 figures

We examine the unitarity of a class of generalized Maxwell U(1) gauge theories in (2+1) D containing the pseudodifferential operator $\Box^{1-\alpha}$, for $\alpha \in [0,1)$. We show that only Quantum Electrodynamics (QED$_3$) and its generalization known as Pseudo Quantum Electrodynamics (PQED), for which $\alpha =0$ and $\alpha = 1/2$, respectively, satisfy unitarity. The latter plays an important role in the description of the electromagnetic interactions of charged particles confined to a plane, such as in graphene or in hetero-junctions displaying the quantum Hall effect., Comment: 6 pages, no figures

We naturally obtain the NOT and CNOT logic gates, which are key pieces of quantum computing algorithms, in the framework of the non-Abelian Chern-Simons-Higgs theory in two spatial dimensions. For that, we consider the anyonic quantum vortex topological excitations occurring in this system and show that self-adjoint (Majorana-like) combinations of these vortices and anti-vortices have in general non-Abelian statistics. The associated unitary monodromy braiding matrices become the required logic gates in the special case when the vortex spin is $s=1/4$. We explicitly construct the vortex field operators, show that they carry both magnetic flux and charge and obtain their euclidean correlation functions by using the method of quantization of topological excitations, which is based on the order-disorder duality. These correlators are in general multivalued, the number of sheets being determined by the vortex spin. This, by its turn, is proportional to the vacuum expectation value of the Higgs field and therefore can be tuned both by the free parameters of the Higgs potential and the temperature., Comment: 22 pages

The present report constitutes the Protocol Manual for ensuring harmonisation of offshore wind and wave simulation being implemented at MaRINET facilities. Wind and wave climates for five offshore wind sites in the North Sea and the Baltic Sea have been presented in terms of probability distributions for wind speed along with a series of lumped sea states and turbulence intensity values, parameterised with respect to the wind speed. Further, extreme values for wind speed and significant wave height have been provided. Further to the wind distributions and lumped characteristics, the Weibull parameters for the wind distribution and explicit formulas for the turbulence intensity and significant wave height are provided. For the correlation of wave peak period and significant wave height, a standard formula from the IEC‐61400‐3 code have been found to cover the scatter in the data, although one coefficient in this formula must be decided upon by the user. Further, the value of γ, the JONSWAP peak enhancement parameter must be chosen by the user. This can be done either from an explicit formula or by the standard choices of γ=1.0 or γ=3.3. Hereby a full description of a unidirectional wind‐wave climate can be constructed. If needed, this climate can be supplemented by the user with the combined directional distribution of wind and waves, either based on data or in terms of parametric studies. The scaling method proposed is the dynamic‐elastic scaling, which maintains the ratios between hydrodynamic, aerodynamic, stiffness‐induced and gravitational forces. This scaling preserves the Froude number for the water phase and the tip speed ratio for the rotor. The Reynolds numbers for air and water, however, are not conserved. A redesign of the model‐scale blades will therefore be needed. Here the scaled thrust‐curve must be matched. Further, if possible, the torque from the airfoil should be matched. This requirement, however, is difficult to achieve due to the change in

The present report constitutes the Protocol Manual for ensuring harmonisation of offshore wind and wave simulation being implemented at MaRINET facilities. Wind and wave climates for five offshore wind sites in the North Sea and the Baltic Sea have been presented in terms of probability distributions for wind speed along with a series of lumped sea states and turbulence intensity values, parameterised with respect to the wind speed. Further, extreme values for wind speed and significant wave height have been provided. Further to the wind distributions and lumped characteristics, the Weibull parameters for the wind distribution and explicit formulas for the turbulence intensity and significant wave height are provided. For the correlation of wave peak period and significant wave height, a standard formula from the IEC‐61400‐3 code have been found to cover the scatter in the data, although one coefficient in this formula must be decided upon by the user. Further, the value of γ, the JONSWAP peak enhancement parameter must be chosen by the user. This can be done either from an explicit formula or by the standard choices of γ=1.0 or γ=3.3. Hereby a full description of a unidirectional wind‐wave climate can be constructed. If needed, this climate can be supplemented by the user with the combined directional distribution of wind and waves, either based on data or in terms of parametric studies. The scaling method proposed is the dynamic‐elastic scaling, which maintains the ratios between hydrodynamic, aerodynamic, stiffness‐induced and gravitational forces. This scaling preserves the Froude number for the water phase and the tip speed ratio for the rotor. The Reynolds numbers for air and water, however, are not conserved. A redesign of the model‐scale blades will therefore be needed. Here the scaled thrust‐curve must be matched. Further, if possible, the torque from the airfoil should be matched. This requirement, however, is difficult to achieve due to the change in

We investigate the competition between the superconducting and the excitonic phases on Dirac electrons on a bipartite planar lattice. The conditions for the appearance of superconductivity or excitonic condensate are given by the minima of the free energy and our results are explained., Comment: 3 pages, Proceedings contribution for Hadrons XII

We investigate the competition between the superconducting and the excitonic phases on Dirac electrons on a bipartite planar lattice. The conditions for the appearance of superconductivity or excitonic condensate are given by the minima of the free energy and our results are explained., Comment: 3 pages, Proceedings contribution for Hadrons XII

OBJECTIVE: Tumor necrosis factor ligand family members B-cell-activating factor (BAFF) and a proliferation-inducing ligand (APRIL) can exert powerful effects on B-cell activation and development, type 1 T-helper cell (Th1) immune responses, and autoimmunity. We examined the effect of blocking BAFF and APRIL on the development of autoimmune diabetes. RESEARCH DESIGN AND METHODS: Female NOD mice were administered B-cell maturation antigen (BCMA)-Fc from 9 to 15 weeks of age. Diabetes incidence, islet pathology, and T- and B-cell populations were examined. RESULTS: BCMA-Fc treatment reduced the severity of insulitis and prevented diabetes development in NOD mice. BCMA-Fc-treated mice showed reduced follicular, marginal-zone, and T2MZ B-cells. B-cell reduction was accompanied by decreased frequencies of pathogenic CD4(+)CD40(+) T-cells and reduced Th1 cytokines IL-7, IL-15, and IL-17. Thus, T-cell activation was blunted with reduced B-cells. However, BCMA-Fc-treated mice still harbored detectable diabetogenic T-cells, suggesting that regulatory mechanisms contributed to diabetes prevention. Indeed, BCMA-Fc-treated mice accumulated increased CD4(+)CD25(+) regulatory T-cells (Tregs) with age. CD4(+)CD25(+) cells were essential for maintaining euglycemia because their depletion abrogated BCMA-Fc-mediated protection. BCMA-Fc did not directly affect Treg homeostasis given that CD4(+)CD25(+)Foxp3(+) T-cells did not express TACI or BR3 receptors and that CD4(+)CD25(+)Foxp3(+) T-cell frequencies were equivalent in wild-type, BAFF(-/-), TACI(-/-), BCMA(-/-), and BR3(-/-) mice. Rather, B-cell depletion resulted in CD4(+)CD25(+) T-cell-mediated protection from diabetes because anti-CD25 monoclonal antibody treatment precipitated diabetes in both diabetes-resistant NOD.microMT(-/-) and BCMA-Fc-treated mice. CONCLUSIONS: BAFF/APRIL blockade prevents diabetes. BCMA-Fc reduces B-cells, subsequently blunting autoimmune activity and allowing endogenous regulatory mechanisms to preserve

The product quality of energetic materials is predominantly determined by the crystallization process applied to produce these materials. It has been demonstrated in the past that the higher the product quality of the solid energetic ingredients, the less sensitive a plastic bonded explosive containing these energetic materials becomes. The application of submicron or nanometric energetic materials is generally considered to further decrease the sensitiveness of explosives. In order to assess the product quality of energetic materials, a range of analytical techniques is available. Recent attempts within the Reduced-sensitivity RDX Round Robin (R4) have provided the EM community a better insight into these analytical techniques and in some cases a correlation between product quality and shock initiation of plastic bonded explosives containing (RS-)RDX was identified, which would provide a possibility to discriminate between conventional and reduced sensitivity grades. In this paper experimental results of two relatively new crystallization techniques are shown. Submicron and nanometric RDX particles have been produced and characterized. Also results on the characterization of different commercial RDX grades will be shown, including data related to a part of the samples received within the R4 programme. Finally, experimental data will be presented and discussed on insensitive plastic bonded explosives (PBXs). © 2008 WILEY-VCH Verlag GmbH & Co. KGaA.

We investigate a sequence of quadratic topological terms of the Chern-Simons type in different spacetime dimensions, related by dimensional compactification and sharing the properties of topological mass generation and statistical transmutation. The implications for bosonization in several dimensions are also analyzed., Comment: 4 pages, Revtex (multicol). To appear in Europhysics Letters