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15 results on '"Martin, N.I."'

7. De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria

Author

't Hart, P., Wood, T.M., Hajmohammadebrahimtehrani, K., van Harten, R.M., Sleszynska, M.K., Breukink, E.J., Martin, N.I., 't Hart, P., Wood, T.M., Hajmohammadebrahimtehrani, K., van Harten, R.M., Sleszynska, M.K., Breukink, E.J., and Martin, N.I.

Abstract

Creative strategies for identifying new antibiotics are essential to addressing the looming threat of a post-antibiotic era. We here report the use of a targeted peptide phage display screen as a means of generating novel antimicrobial lipopeptides. Specifically, a library of phage displayed bicyclic peptides was screened against a biomolecular target based on the bacterial cell wall precursor lipid II. In doing so we identified unique lipid II binding peptides that upon lipidation were found to be active against a range of Gram-positive bacteria including clinically relevant strains of vancomycin resistant bacteria. Optimization of the peptide sequence led to variants with enhanced antibacterial activity and reduced hemolytic activity. Biochemical experiments further confirm a lipid II mediated mode of action for these new-to-nature antibacterial lipopeptides.

Published
2017

9. De novo identification of lipid II binding lipopeptides with antibacterial activity against vancomycin-resistant bacteria

Author

Membrane Biochemistry and Biophysics, Chemical Biology and Drug Discovery, Sub Medicinal Chemistry & Chemical biol., Afd Chemical Biology and Drug Discovery, Sub Membrane Biochemistry & Biophysics, 't Hart, P., Wood, T.M., Hajmohammadebrahimtehrani, K., van Harten, R.M., Sleszynska, M.K., Breukink, E.J., Martin, N.I., Membrane Biochemistry and Biophysics, Chemical Biology and Drug Discovery, Sub Medicinal Chemistry & Chemical biol., Afd Chemical Biology and Drug Discovery, Sub Membrane Biochemistry & Biophysics, 't Hart, P., Wood, T.M., Hajmohammadebrahimtehrani, K., van Harten, R.M., Sleszynska, M.K., Breukink, E.J., and Martin, N.I.

Published
2017

10. N-eta-Substituted arginyl peptide inhibitors of protein arginine N-methyltransferases

Author

Medicinal Chemistry and Chemical Biology, SYNTHESE, LS Bestuurkunde, Dep Farmaceutische wetenschappen, UU LEG Research USG Public Matters, Lakowski, T.M., 't Hart, P., Ahern, C.A., Martin, N.I., Frankel, A., Medicinal Chemistry and Chemical Biology, SYNTHESE, LS Bestuurkunde, Dep Farmaceutische wetenschappen, UU LEG Research USG Public Matters, Lakowski, T.M., 't Hart, P., Ahern, C.A., Martin, N.I., and Frankel, A.

Published
2010

11. N-eta-Substituted arginyl peptide inhibitors of protein arginine N-methyltransferases

Author

Medicinal Chemistry and Chemical Biology, SYNTHESE, LS Bestuurkunde, Dep Farmaceutische wetenschappen, UU LEG Research USG Public Matters, Lakowski, T.M., 't Hart, P., Ahern, C.A., Martin, N.I., Frankel, A., Medicinal Chemistry and Chemical Biology, SYNTHESE, LS Bestuurkunde, Dep Farmaceutische wetenschappen, UU LEG Research USG Public Matters, Lakowski, T.M., 't Hart, P., Ahern, C.A., Martin, N.I., and Frankel, A.

Published
2010

12. N-eta-Substituted arginyl peptide inhibitors of protein arginine N-methyltransferases

Author

Medicinal Chemistry and Chemical Biology, SYNTHESE, LS Bestuurkunde, Dep Farmaceutische wetenschappen, UU LEG Research USG Public Matters, Lakowski, T.M., 't Hart, P., Ahern, C.A., Martin, N.I., Frankel, A., Medicinal Chemistry and Chemical Biology, SYNTHESE, LS Bestuurkunde, Dep Farmaceutische wetenschappen, UU LEG Research USG Public Matters, Lakowski, T.M., 't Hart, P., Ahern, C.A., Martin, N.I., and Frankel, A.

Published
2010

14. The expanding role of lipid II as a target for lantibiotics

Author

Biochemie van Membranen, Chemical Biology & Organic Chemistry, SYNTHESE, Dep Farmaceutische wetenschappen, Dep Scheikunde, Martin, N.I., Breukink, E.J., Biochemie van Membranen, Chemical Biology & Organic Chemistry, SYNTHESE, Dep Farmaceutische wetenschappen, Dep Scheikunde, Martin, N.I., and Breukink, E.J.

Published
2007

15. The expanding role of lipid II as a target for lantibiotics

Author

Biochemie van Membranen, Chemical Biology & Organic Chemistry, SYNTHESE, Dep Farmaceutische wetenschappen, Dep Scheikunde, Martin, N.I., Breukink, E.J., Biochemie van Membranen, Chemical Biology & Organic Chemistry, SYNTHESE, Dep Farmaceutische wetenschappen, Dep Scheikunde, Martin, N.I., and Breukink, E.J.

Published
2007

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