1. Endometrial carcinomas with dyshesive, eosinophilic, and vacuolated (histiocyte-like) tumor cells: a reactive-like phenotype associated with aggressive behavior
- Author
-
Travaglino, A, Arciuolo, Damiano, Raffone, A, Santoro, Angela, Piermattei, Angelo, Navarra, E, Minucci, Angelo, Mascolo, M, Scaglione, G, D'Alessandris, N, Valente, Marianna, Inzani, Frediano, Mollo, A, Insabato, L, Zannoni, Gian Franco, Arciuolo, D, Santoro, A (ORCID:0000-0002-6964-5152), Piermattei, A (ORCID:0000-0002-6835-1179), Minucci, A, Valente, M, Inzani, F, Zannoni, GF (ORCID:0000-0003-1809-129X), Travaglino, A, Arciuolo, Damiano, Raffone, A, Santoro, Angela, Piermattei, Angelo, Navarra, E, Minucci, Angelo, Mascolo, M, Scaglione, G, D'Alessandris, N, Valente, Marianna, Inzani, Frediano, Mollo, A, Insabato, L, Zannoni, Gian Franco, Arciuolo, D, Santoro, A (ORCID:0000-0002-6964-5152), Piermattei, A (ORCID:0000-0002-6835-1179), Minucci, A, Valente, M, Inzani, F, and Zannoni, GF (ORCID:0000-0003-1809-129X)
- Abstract
Herein, we present a clinicopathological and molecular analysis of four cases of endometrial carcinoma (EC) diffusely exhibiting dyshesive cells with wide eosinophilic and vacuolated cytoplasm (histiocyte-like tumor cells, HLTCs). We compared these HLTCs to similar cells found in microcystic, elongated and fragmented (MELF) pattern (n = 20) or after neoadjuvant chemotherapy (NAC) (n = 5). The four cases were endometrioid, serous, clear cell, and gastric-type; all were at FIGO stage >= III. HLTCs showed an epithelial Mullerian phenotype and at least focal CK20, HNF1 beta, and CK5/6 expression, with aberrant e-cadherin and beta-catenin expression; two cases were MMR-deficient, and one was p53-abnormal; all were POLE wild type. MELF-associated and NAC-associated HLTCs showed similar morphological/immunophenotypical features. However, MELF-associated HLTCs were mainly intraglandular and inflammation-associated, did not form a distinct tumor component, and showed no relationship with lymph node metastases. In conclusion, different histotypes of EC may show a prominent HLTC component, which shows peculiar morphological/immunophenotypical features and appears associated with aggressive behavior.
- Published
- 2022