1. Estimating motor unit numbers from a CMAP scan:Repeatability study on three muscles at 15 centres
- Author
-
Sørensen, D. M., Bostock, H., Abrahao, A., Alaamel, A., Alaydin, H. C., Ballegaard, M., Boran, E., Cengiz, B., de Carvalho, M., Dunker, Fuglsang-Frederiksen, A., Graffe, C. C., Jones, K. E., Kallio, M., Kalra, S., Krarup, C., Krøigård, T., Liguori, R., Lupescu, T., Maitland, S., Matamala, J. M., Moldovan, M., Moreno-Roco, J., Nilsen, K. B., Phung, L., Santos, M. O., Themistocleous, A. C., Uysal, H., Vacchiano, V., Whittaker, R. G., Zinman, L., Tankisi, H., Sørensen, D. M., Bostock, H., Abrahao, A., Alaamel, A., Alaydin, H. C., Ballegaard, M., Boran, E., Cengiz, B., de Carvalho, M., Dunker, Fuglsang-Frederiksen, A., Graffe, C. C., Jones, K. E., Kallio, M., Kalra, S., Krarup, C., Krøigård, T., Liguori, R., Lupescu, T., Maitland, S., Matamala, J. M., Moldovan, M., Moreno-Roco, J., Nilsen, K. B., Phung, L., Santos, M. O., Themistocleous, A. C., Uysal, H., Vacchiano, V., Whittaker, R. G., Zinman, L., and Tankisi, H.
- Abstract
Objective: To assess the repeatability and suitability for multicentre studies of MScanFit motor unit number estimation (MUNE), which involves modelling compound muscle action potential (CMAP) scans. Methods: Fifteen groups in 9 countries recorded CMAP scans twice, 1–2 weeks apart in healthy subjects from abductor pollicis brevis (APB), abductor digiti minimi (ADM) and tibialis anterior (TA) muscles. The original MScanFit program (MScanFit-1) was compared with a revised version (MScanFit-2), designed to accommodate different muscles and recording conditions by setting the minimal motor unit size as a function of maximum CMAP. Results: Complete sets of 6 recordings were obtained from 148 subjects. CMAP amplitudes differed significantly between centres for all muscles, and the same was true for MScanFit-1 MUNE. With MScanFit-2, MUNE differed less between centres but remained significantly different for APB. Coefficients of variation between repeats were 18.0% for ADM, 16.8% for APB, and 12.1% for TA. Conclusions: It is recommended for multicentre studies to use MScanFit-2 for analysis. TA provided the least variable MUNE values between subjects and the most repeatable within subjects. Significance: MScanFit was primarily devised to model the discontinuities in CMAP scans in patients and is less suitable for healthy subjects with smooth scans.
- Published
- 2023