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3 results on '"McDade, SS"'

1. Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation.

Author

Ashworth, Alan, Ashworth, Alan, McDade, SS, Henry, AE, Pivato, GP, Kozarewa, I, Mitsopoulos, C, Fenwick, K, Assiotis, I, Hakas, J, Zvelebil, M, Orr, N, Ashworth, Alan, Ashworth, Alan, McDade, SS, Henry, AE, Pivato, GP, Kozarewa, I, Mitsopoulos, C, Fenwick, K, Assiotis, I, Hakas, J, Zvelebil, M, and Orr, N

Abstract

The p63 transcription factor (TP63) is critical in development, growth and differentiation of stratifying epithelia. This is highlighted by the severity of congenital abnormalities caused by TP63 mutations in humans, the dramatic phenotypes in knockout mic

Published
2012

2. Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk

Author

Orr, N, Lemnrau, A, Cooke, R, Fletcher, O, Tomczyk, K, Jones, M, Johnson, N, Lord, CJ, Mitsopoulos, C, Zvelebil, M, McDade, SS, Buck, G, Blancher, C, Trainer, AH, James, PA, Bojesen, SE, Bokmand, S, Nevanlinna, H, Mattson, J, Friedman, E, Laitman, Y, Palli, D, Masala, G, Zanna, I, Ottini, L, Giannini, G, Hollestelle, A, van den Ouweland, AMW, Novakovic, S, Krajc, M, Gago-Dominguez, M, Castelao, JE, Olsson, H, Hedenfalk, I, Easton, DF, Pharoah, PDP, Dunning, AM, Bishop, DT, Neuhausen, SL, Steele, L, Houlston, RS, Garcia-Closas, M, Ashworth, A, Swerdlow, AJ, Orr, N, Lemnrau, A, Cooke, R, Fletcher, O, Tomczyk, K, Jones, M, Johnson, N, Lord, CJ, Mitsopoulos, C, Zvelebil, M, McDade, SS, Buck, G, Blancher, C, Trainer, AH, James, PA, Bojesen, SE, Bokmand, S, Nevanlinna, H, Mattson, J, Friedman, E, Laitman, Y, Palli, D, Masala, G, Zanna, I, Ottini, L, Giannini, G, Hollestelle, A, van den Ouweland, AMW, Novakovic, S, Krajc, M, Gago-Dominguez, M, Castelao, JE, Olsson, H, Hedenfalk, I, Easton, DF, Pharoah, PDP, Dunning, AM, Bishop, DT, Neuhausen, SL, Steele, L, Houlston, RS, Garcia-Closas, M, Ashworth, A, and Swerdlow, AJ

Abstract

We conducted a genome-wide association study of male breast cancer comprising 823 cases and 2,795 controls of European ancestry, with validation in independent sample sets totaling 438 cases and 474 controls. A SNP in RAD51B at 14q24.1 was significantly associated with male breast cancer risk (P = 3.02 × 10(-13); odds ratio (OR) = 1.57). We also refine association at 16q12.1 to a SNP within TOX3 (P = 3.87 × 10(-15); OR = 1.50).

Published
2012

3. Genome-wide analysis of p63 binding sites identifies AP-2 factors as co-regulators of epidermal differentiation.

Author

Ashworth, Alan, Ashworth, Alan, McDade, SS, Henry, AE, Pivato, GP, Kozarewa, I, Mitsopoulos, C, Fenwick, K, Assiotis, I, Hakas, J, Zvelebil, M, Orr, N, Ashworth, Alan, Ashworth, Alan, McDade, SS, Henry, AE, Pivato, GP, Kozarewa, I, Mitsopoulos, C, Fenwick, K, Assiotis, I, Hakas, J, Zvelebil, M, and Orr, N

Abstract

The p63 transcription factor (TP63) is critical in development, growth and differentiation of stratifying epithelia. This is highlighted by the severity of congenital abnormalities caused by TP63 mutations in humans, the dramatic phenotypes in knockout mic

Published
2012

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