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18 results on '"Mcshane, M"'

1. Enterprise Risk Management: Review, Critique, and Research Directions

Author

Bromiley, P, Bromiley, P, McShane, M, Nair, A, Rustambekov, E, Bromiley, P, Bromiley, P, McShane, M, Nair, A, and Rustambekov, E

Abstract

© 2014 Elsevier Ltd. Many regulators, rating agencies, executives and academics have advocated a new approach to risk management: Enterprise Risk Management (ERM). ERM proposes the integrated management of all the risks an organization faces, which inherently requires alignment of risk management with corporate governance and strategy. Academic research on ERM is still in its infancy, with articles largely in accounting and finance journals but rarely in management journals. We argue that ERM offers an important new research domain for management scholars. A critical review of ERM research allows us to identify limitations and gaps that management scholars are best equipped to address. This paper not only identifies how management scholars can contribute to ERM research, but also points out why ERM research (and practice) needs management research for its development.

Published
2015

2. Enterprise Risk Management: Review, Critique, and Research Directions

Author

Bromiley, P, Bromiley, P, McShane, M, Nair, A, Rustambekov, E, Bromiley, P, Bromiley, P, McShane, M, Nair, A, and Rustambekov, E

Abstract

© 2014 Elsevier Ltd. Many regulators, rating agencies, executives and academics have advocated a new approach to risk management: Enterprise Risk Management (ERM). ERM proposes the integrated management of all the risks an organization faces, which inherently requires alignment of risk management with corporate governance and strategy. Academic research on ERM is still in its infancy, with articles largely in accounting and finance journals but rarely in management journals. We argue that ERM offers an important new research domain for management scholars. A critical review of ERM research allows us to identify limitations and gaps that management scholars are best equipped to address. This paper not only identifies how management scholars can contribute to ERM research, but also points out why ERM research (and practice) needs management research for its development.

Published
2015

3. Learning to express 'left-right' & 'front-behind' in a sign versus spoken language

Author

Bello, P., Guarini, M., McShane, M., Scassellati, B., Sümer, B., Perniss, P.M., Zwitserlood, I.E.P., Özyürek, A., Bello, P., Guarini, M., McShane, M., Scassellati, B., Sümer, B., Perniss, P.M., Zwitserlood, I.E.P., and Özyürek, A.

Abstract

COGSCI, 23 juli 2014, Contains fulltext : 131349.pdf (publisher's version ) (Open Access)

Published
2014

6. Modelling reading times in bilingual sentence comprehension

Author

Bello, P., Guarini, M., McShane, M., Scassellati, B., Frank, S.L., Bello, P., Guarini, M., McShane, M., Scassellati, B., and Frank, S.L.

Abstract

Cognitive Science Society, 23 juli 2014, Contains fulltext : 131350.pdf (author's version ) (Open Access)

Published
2014

7. Learning to express 'left-right' & 'front-behind' in a sign versus spoken language

Author

Bello, P., Guarini, M., McShane, M., Scassellati, B., Sümer, B., Perniss, P.M., Zwitserlood, I.E.P., Özyürek, A., Bello, P., Guarini, M., McShane, M., Scassellati, B., Sümer, B., Perniss, P.M., Zwitserlood, I.E.P., and Özyürek, A.

Abstract

COGSCI, 23 juli 2014, Contains fulltext : 131349.pdf (publisher's version ) (Open Access)

Published
2014

10. Modelling reading times in bilingual sentence comprehension

Author

Bello, P., Guarini, M., McShane, M., Scassellati, B., Frank, S.L., Bello, P., Guarini, M., McShane, M., Scassellati, B., and Frank, S.L.

Abstract

Cognitive Science Society, 23 juli 2014, Contains fulltext : 131350.pdf (author's version ) (Open Access)

Published
2014

11. A Dual Process Theory of Optimistic Cognition

Author

Bello, P., Guarini, M., McShane, M., Scassellati, B., Sunehag, Peter, Hutter, Marcus, Bello, P., Guarini, M., McShane, M., Scassellati, B., Sunehag, Peter, and Hutter, Marcus

Published
2014

14. APPL proteins modulate DNA repair and radiation survival of pancreatic carcinoma cells by regulating ATM

Author

Hennig, J., Mcshane, M., Cordes, N., Eke, I., Hennig, J., Mcshane, M., Cordes, N., and Eke, I.

Abstract

Despite intensive multimodal therapies, the overall survival rate of patients with ductal adenocarcinoma of the pancreas is still poor. The chemo- and radioresistance mechanisms of this tumor entity remain to be determined in order to develop novel treatment strategies. In cancer, endocytosis and membrane trafficking proteins are known to be utilized and they also critically regulate essential cell functions like survival and proliferation. On the basis of these data, we evaluated the role of the endosomal proteins adaptor proteins containing pleckstrin homology domain, phosphotyrosine binding domain and a leucine zipper motif (APPL) 1 and 2 for the radioresistance of pancreatic carcinoma cells. Here, we show that APPL2 expression in pancreatic cancer cells is upregulated after irradiation and that depletion of APPL proteins by small interfering RNA (siRNA) significantly reduced radiation survival in parallel to impairing DNA double strand break (DSB) repair. In addition, APPL knockdown diminished radiogenic hyperphosphorylation of ataxia telangiectasia mutated (ATM). Activated ATM and APPL1 were also shown to interact after irradiation, suggesting that APPL has a more direct role in the phosphorylation of ATM. Double targeting of APPL proteins and ATM caused similar radiosensitization and concomitant DSB repair perturbation to that observed after depletion of single proteins, indicating that ATM is the central modulator of APPL-mediated effects on radiosensitivity and DNA repair. These data strongly suggest that endosomal APPL proteins contribute to the DNA damage response. Whether targeting of APPL proteins is beneficial for the survival of patients with pancreatic adenocarcinoma remains to be elucidated.

Published
2014

15. Microcapsules ejecting nanosized species into the environment

Author

Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, de Geest, B.G., McShane, M., Demeester, J., de Smedt, S.C., Hennink, W.E., Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, de Geest, B.G., McShane, M., Demeester, J., de Smedt, S.C., and Hennink, W.E.

Published
2008

16. Microcapsules ejecting nanosized species into the environment

Author

Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, de Geest, B.G., McShane, M., Demeester, J., de Smedt, S.C., Hennink, W.E., Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, de Geest, B.G., McShane, M., Demeester, J., de Smedt, S.C., and Hennink, W.E.

Published
2008

17. Microcapsules ejecting nanosized species into the environment

Author

Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, de Geest, B.G., McShane, M., Demeester, J., de Smedt, S.C., Hennink, W.E., Advanced drug delivery systems/drug targeting, Dep Farmaceutische wetenschappen, de Geest, B.G., McShane, M., Demeester, J., de Smedt, S.C., and Hennink, W.E.

Published
2008

18. Field Evaluation of Hazardous Waste Site Bioassessment Protocols. Volume 2.

Author

BATTELLE MEMORIAL INST RICHLAND WA PACIFIC NORTHWEST LABS, Thomas, J. M., Cline, J. F., Gano, K. A., McShane, M. C., Rogers, J. E., BATTELLE MEMORIAL INST RICHLAND WA PACIFIC NORTHWEST LABS, Thomas, J. M., Cline, J. F., Gano, K. A., McShane, M. C., and Rogers, J. E.

Abstract

The initial step in providing information on the behavior of hazardous chemicals was made with the identification of laboratory bioassay procedures. RMA has chosen as the site to initiate field evaluation of bioassessment procedures. Volume I reports on FY 1982 research, and volume II reports on the revised plan for FY 1983. -BKA

Published
1984

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