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Ménétrier-like disease is a rare hypertrophic canine gastropathy, reported in only seven dogs. Clinical signs are vomiting, anorexia and weight loss. Macroscopically, giant cerebriform gastric mucosal folds are typically seen in the corpus and fundus of the stomach. Histopathologically, fundic mucous cell hyperplasia and loss of parietal and chief cells are typical. A nine-year-old spayed female Pointer had a history of intermittent vomiting, marked weight loss and hypoalbuminaemia. A gastroduodenoscopy was performed three times within three months with macroscopic changes remaining the same. The gastric mucosa of the corpus, fundus and proximal antrum was markedly irregular, with cerebriform mucosal folds. In the first gastric biopsies, histopathology revealed a moderate granulomatous gastritis, with a severe manifestation of Helicobacter -like organisms. Treatment for Helicobacter spp. decreased the vomiting slightly. The dog was diagnosed with concurrent leishmaniosis; the conventional anti- Leishmania treatment decreased the vomiting moderately, the hypoalbuminaemia resolved and the dog gained weight back to a normal body condition. Granulomatous gastritis was not present in the gastric biopsies after these treatments. The dog increased vomiting when palliative treatment (maropitant citrate, ondansetron and esomeprazole) was discontinued, and thus, full-thickness biopsies of the stomach were taken and Ménétrier-like disease was diagnosed. The affected area was too large to be surgically removed; thus, palliative treatment was reinstated. The dog remained clinically well 39 months after the first clinical presentation. This is the first report of Ménétrier-like disease in a dog with a simultaneous manifestation of granulomatous gastritis, helicobacteriosis and leishmaniosis. The clinical signs decreased after treatment of helicobacteriosis and leishmaniosis, but vomiting remained probably as a sign of Ménétrier-like disease. Treatment options for dogs are surgica

A clinical case of a 56-year-old adult, was treated at the Surgery Service of the Teaching Surgical Clinical Hospital “Dr. Ambrosio Grillo”, Santiago de Cuba province, which was operated urgently with the preoperative diagnosis of complicated gastric cancer. The pathological study did not confirm this diagnosis and did show Ménétrier disease. The patient did not present complications in his postoperative evolution, so he discharged the hospital 7 days later., O caso clínico de um adulto de 56 anos, atendido no Serviço de Cirurgia do Hospital Clínico Cirúrgico de Ensino “Dr. Ambrosio Grillo”, província de Santiago de Cuba, operada com urgência com o diagnóstico pré-operatório de câncer gástrico complicado. O estudo patológico não confirmou esse diagnóstico e mostrou a doença de Ménétrier. O paciente não apresentou complicações em sua evolução pós-operatória e, assim, aos 7 dias ele saui do hospital., Se presentó el caso clínico de un adulto de 56 años de edad, atendido en el Servicio de Cirugía del Hospital Clínico Quirúrgico Docente “Dr. Ambrosio Grillo”, provincia Santiago de Cuba, que fue operado de urgencia con el diagnóstico preoperatorio de cáncer gástrico complicado. El estudio anatomopatológico no confirmó dicho diagnóstico y sí evidenció enfermedad de Ménétrier. El paciente no presentó complicaciones en su evolución posoperatoria, por lo que se egresó 7 días después.

Helicobacter pylori (H. pylori) is now regarded as a pathogen for various disease of the gastrointestinal tract. Recent reports indicated that it rarely causes protein loss from the stomach leading to hypoproteinemia, a condition termed as protein-losing gastropathy (PLG). Several conditions are recognized in protein-losing gastropathy caused by H. pylori. Hypertrophic gastropathy with protein-loss, traditionally called Menetrier's disease, is one of manifestations of this condition. This condition may be subdivided in two categories; hypertrophic gastropathy with minimal inflammation and hypertrophic gastritis with giant folds. The latter includes a histological entity termed hypertrophic lymphocytic gastritis. Varioliform gastritis that has characteristic endoscopic features is another entity of the condition showing PLG, which also often shows histological features of lymphocytic gastritis. To our knowledge, lymphocytic gastritis is a rarely seen in Japanese patients. Previously, these conditions were treated with various drugs such as a somatostatin analogue, H2 receptor antagonist, and proton pump inhibitor, resulting in incomplete responses. Recently, a significant number of reports have documented usefulness of eradication therapy for H. pylori. As more than 90 % of patients with gastropathy or gastritis accompanying PLG are positive for H. pylori, treatment of its infection in these patients with PLG is recommended., Acta medica Nagasakiensia. 2002, 47(1-2), p.1-7