Search

Your search keyword '"Modena, Piergiorgio"' showing total 7 results
Start Over Author "Modena, Piergiorgio" Database OAIster
7 results on '"Modena, Piergiorgio"'

1. Second series by the Italian Association of Pediatric Hematology and Oncology of children and adolescents with intracranial ependymoma: an integrated molecular and clinical characterization with a long-term follow-up

Author

Massimino, Maura, Barretta, Francesco, Modena, Piergiorgio, Witt, Hendrik, Minasi, Simone, Pfister, Stefan M, Pajtler, Kristian W, Antonelli, Manila, Gandola, Lorenza, Luisa Garrè, Maria, Bertin, Daniele, Mastronuzzi, Angela, Mascarin, Maurizio, Quaglietta, Lucia, Viscardi, Elisabetta, Sardi, Iacopo, Ruggiero, Antonio, Pollo, Bianca, Buccoliero, Annamaria, Boschetti, Luna, Schiavello, Elisabetta, Chiapparini, Luisa, Erbetta, Alessandra, Morra, Isabella, Gessi, Marco, Donofrio, Vittoria, Patriarca, Carlo, Giangaspero, Felice, Johann, Pascal, Buttarelli, Francesca Romana, Ruggiero, Antonio (ORCID:0000-0002-6052-3511), Massimino, Maura, Barretta, Francesco, Modena, Piergiorgio, Witt, Hendrik, Minasi, Simone, Pfister, Stefan M, Pajtler, Kristian W, Antonelli, Manila, Gandola, Lorenza, Luisa Garrè, Maria, Bertin, Daniele, Mastronuzzi, Angela, Mascarin, Maurizio, Quaglietta, Lucia, Viscardi, Elisabetta, Sardi, Iacopo, Ruggiero, Antonio, Pollo, Bianca, Buccoliero, Annamaria, Boschetti, Luna, Schiavello, Elisabetta, Chiapparini, Luisa, Erbetta, Alessandra, Morra, Isabella, Gessi, Marco, Donofrio, Vittoria, Patriarca, Carlo, Giangaspero, Felice, Johann, Pascal, Buttarelli, Francesca Romana, and Ruggiero, Antonio (ORCID:0000-0002-6052-3511)

Abstract

Background. A prospective 2002-2014 study stratified 160 patients by resection extent and histological grade, reporting results in 2016. We re-analyzed the series after a median of 119 months, adding retrospectively patients' molecular features.Methods. Follow-up of all patients was updated. DNA copy number analysis and gene-fusion detection could be completed for 94/160 patients, methylation classification for 68.Results. Progression-free survival (PFS) and overall survival (OS) at 5/10 years were 66/58%, and 80/73%. Ten patients had late relapses (range 66-126 mo), surviving after relapse no longer than those relapsing earlier (0-5 y). On multivariable analysis a better PFS was associated with grade II tumor and complete surgery at diagnosis and/or at radiotherapy; female sex and complete resection showed a positive association with OS. Posterior fossa (PF) tumors scoring >= 0.80 on DNA methylation analysis were classified as PFA (n = 41) and PFB (n = 9). PFB patients had better PFS and OS. Eighteen/32 supratentorial tumors were classified as RELA, and 3 as other molecular entities (anaplastic PXA, LGG MYB, HGNET). RELA had no prognostic impact. Patients with 1q gain or cyclin-dependent kinase inhibitor 2A (CDKN2A) loss had worse outcomes, included significantly more patients >3 years old (P = 0.050) and cases of dissemination at relapse (P = 0.007).Conclusions. Previously described prognostic factors were confirmed at 10-year follow-up. Late relapses occurred in 6.2% of patients. Specific molecular features may affect outcome: PFB patients had a very good prognosis; 1q gain and CDKN2A loss were associated with dissemination. To draw reliable conclusions, modern ependymoma trials need to combine diagnostics with molecular risk stratification and long-term follow-up.

Published
2021

2. Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG) : A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries

Author

Hoffman, Lindsey M., van Zanten, Sophie E. M. Veldhuijzen, Colditz, Niclas, Baugh, Joshua, Chaney, Brooklyn, Hoffmann, Marion, Lane, Adam, Fuller, Christine, Miles, Lili, Hawkins, Cynthia, Bartels, Ute, Bouffet, Eric, Goldman, Stewart, Leary, Sarah, Foreman, Nicholas K., Packer, Roger, Warren, Katherine E., Broniscer, Alberto, Kieran, Mark W., Minturn, Jane, Comito, Melanie, Broxson, Emmett, Shih, Chie-Schin, Khatua, Soumen, Chintagumpala, Murali, Carret, Anne Sophie, Escorza, Nancy Yanez, Hassall, Timothy, Ziegler, David S., Gottardo, Nicholas, Dholaria, Hetal, Doughman, Renee, Benesch, Martin, Drissi, Rachid, Nazarian, Javad, Jabado, Nada, Boddaert, Nathalie, Varlet, Pascale, Giraud, Geraldine, Castel, David, Puget, Stephanie, Jones, Chris, Hulleman, Esther, Modena, Piergiorgio, Giagnacovo, Marzia, Antonelli, Manila, Pietsch, Torsten, Gielen, Gerrit H., Jones, David T. W., Sturm, Dominik, Pfister, Stefan M., Gerber, Nicolas U., Grotzer, Michael A., Pfaff, Elke, von Bueren, Andre O., Hargrave, Darren, Solanki, Guirish A., Cvrlje, Filip Jadrijevic, Kaspers, Gertjan J. L., Vandertop, William P., Grill, Jacques, Bailey, Simon, Biassoni, Veronica, Massimino, Maura, Calmon, Raphael, Sanchez, Esther, Bison, Brigitte, Warmuth-Metz, Monika, Leach, James, Jones, Blaise, van Vuurden, Dannis G., Kramm, Christof M., Fouladi, Maryam, Hoffman, Lindsey M., van Zanten, Sophie E. M. Veldhuijzen, Colditz, Niclas, Baugh, Joshua, Chaney, Brooklyn, Hoffmann, Marion, Lane, Adam, Fuller, Christine, Miles, Lili, Hawkins, Cynthia, Bartels, Ute, Bouffet, Eric, Goldman, Stewart, Leary, Sarah, Foreman, Nicholas K., Packer, Roger, Warren, Katherine E., Broniscer, Alberto, Kieran, Mark W., Minturn, Jane, Comito, Melanie, Broxson, Emmett, Shih, Chie-Schin, Khatua, Soumen, Chintagumpala, Murali, Carret, Anne Sophie, Escorza, Nancy Yanez, Hassall, Timothy, Ziegler, David S., Gottardo, Nicholas, Dholaria, Hetal, Doughman, Renee, Benesch, Martin, Drissi, Rachid, Nazarian, Javad, Jabado, Nada, Boddaert, Nathalie, Varlet, Pascale, Giraud, Geraldine, Castel, David, Puget, Stephanie, Jones, Chris, Hulleman, Esther, Modena, Piergiorgio, Giagnacovo, Marzia, Antonelli, Manila, Pietsch, Torsten, Gielen, Gerrit H., Jones, David T. W., Sturm, Dominik, Pfister, Stefan M., Gerber, Nicolas U., Grotzer, Michael A., Pfaff, Elke, von Bueren, Andre O., Hargrave, Darren, Solanki, Guirish A., Cvrlje, Filip Jadrijevic, Kaspers, Gertjan J. L., Vandertop, William P., Grill, Jacques, Bailey, Simon, Biassoni, Veronica, Massimino, Maura, Calmon, Raphael, Sanchez, Esther, Bison, Brigitte, Warmuth-Metz, Monika, Leach, James, Jones, Blaise, van Vuurden, Dannis G., Kramm, Christof M., and Fouladi, Maryam

Abstract

Purpose Diffuse intrinsic pontine glioma (DIPG) is a brainstem malignancy with a median survival of < 1 year. The International and European Society for Pediatric Oncology DIPG Registries collaborated to compare clinical, radiologic, and histomolecular characteristics between short-term survivors (STSs) and long-term survivors (LTSs). Materials and Methods Data abstracted from registry databases included patients from North America, Australia, Germany, Austria, Switzerland, the Netherlands, Italy, France, the United Kingdom, and Croatia. Results Among 1,130 pediatric and young adults with radiographically confirmed DIPG, 122 (11%) were excluded. Of the 1,008 remaining patients, 101 (10%) were LTSs (survival 2 years). Median survival time was 11 months (interquartile range, 7.5 to 16 months), and 1-, 2-, 3-, 4-, and 5-year survival rates were 42.3% (95% CI, 38.1% to 44.1%), 9.6% (95% CI, 7.8% to 11.3%), 4.3% (95% CI, 3.2% to 5.8%), 3.2% (95% CI, 2.4% to 4.6%), and 2.2% (95% CI, 1.4% to 3.4%), respectively. LTSs, compared with STSs, more commonly presented at age < 3 or > 10 years (11% v 3% and 33% v 23%, respectively; P < .001) and with longer symptom duration (P < .001). STSs, compared with LTSs, more commonly presented with cranial nerve palsy (83% v 73%, respectively; P = .008), ring enhancement (38% v 23%, respectively; P = .007), necrosis (42% v 26%, respectively; P = .009), and extrapontine extension (92% v 86%, respectively; P = .04). LTSs more commonly received systemic therapy at diagnosis (88% v 75% for STSs; P = .005). Biopsies and autopsies were performed in 299 patients (30%) and 77 patients (10%), respectively; 181 tumors (48%) were molecularly characterized. LTSs were more likely to harbor a HIST1H3B mutation (odds ratio, 1.28; 95% CI, 1.1 to 1.5; P = .002). Conclusion We report clinical, radiologic, and molecular factors that correlate with survival in children and young adults with DIPG, which are important for risk stratification in f

Published
2018
Full Text
View/download PDF

3. Biological material collection to advance translational research and treatment of children with CNS tumours : position paper from the SIOPE Brain Tumour Group

Author

Rutkowski, Stefan, Modena, Piergiorgio, Williamson, Daniel, Kerl, Kornelius, Nysom, Karsten, Pizer, Barry, Bartels, Ute, Puget, Stephanie, Doz, François, Michalski, Antony, von Hoff, Katja, Chevignard, Mathilde, Avula, Shivaram, Murray, Matthew J., Schönberger, Stefan, Czech, Thomas, Schouten-van Meeteren, Antoinette Y.N., Kordes, Uwe, Kramm, Christof M., van Vuurden, Dannis G., Hulleman, Esther, Janssens, Geert O., Solanki, Guirish A., van Veelen, Marie Luise C., Thomale, Ulrich, Schuhmann, Martin U., Jones, Chris, Giangaspero, Felice, Figarella-Branger, Dominique, Pietsch, Torsten, Clifford, Steve C., Pfister, Stefan M., Van Gool, Stefaan W., Rutkowski, Stefan, Modena, Piergiorgio, Williamson, Daniel, Kerl, Kornelius, Nysom, Karsten, Pizer, Barry, Bartels, Ute, Puget, Stephanie, Doz, François, Michalski, Antony, von Hoff, Katja, Chevignard, Mathilde, Avula, Shivaram, Murray, Matthew J., Schönberger, Stefan, Czech, Thomas, Schouten-van Meeteren, Antoinette Y.N., Kordes, Uwe, Kramm, Christof M., van Vuurden, Dannis G., Hulleman, Esther, Janssens, Geert O., Solanki, Guirish A., van Veelen, Marie Luise C., Thomale, Ulrich, Schuhmann, Martin U., Jones, Chris, Giangaspero, Felice, Figarella-Branger, Dominique, Pietsch, Torsten, Clifford, Steve C., Pfister, Stefan M., and Van Gool, Stefaan W.

Published
2018

4. Biological material collection to advance translational research and treatment of children with CNS tumours : position paper from the SIOPE Brain Tumour Group

Author

Rutkowski, Stefan, Modena, Piergiorgio, Williamson, Daniel, Kerl, Kornelius, Nysom, Karsten, Pizer, Barry, Bartels, Ute, Puget, Stephanie, Doz, François, Michalski, Antony, von Hoff, Katja, Chevignard, Mathilde, Avula, Shivaram, Murray, Matthew J., Schönberger, Stefan, Czech, Thomas, Schouten-van Meeteren, Antoinette Y.N., Kordes, Uwe, Kramm, Christof M., van Vuurden, Dannis G., Hulleman, Esther, Janssens, Geert O., Solanki, Guirish A., van Veelen, Marie Luise C., Thomale, Ulrich, Schuhmann, Martin U., Jones, Chris, Giangaspero, Felice, Figarella-Branger, Dominique, Pietsch, Torsten, Clifford, Steve C., Pfister, Stefan M., Van Gool, Stefaan W., Rutkowski, Stefan, Modena, Piergiorgio, Williamson, Daniel, Kerl, Kornelius, Nysom, Karsten, Pizer, Barry, Bartels, Ute, Puget, Stephanie, Doz, François, Michalski, Antony, von Hoff, Katja, Chevignard, Mathilde, Avula, Shivaram, Murray, Matthew J., Schönberger, Stefan, Czech, Thomas, Schouten-van Meeteren, Antoinette Y.N., Kordes, Uwe, Kramm, Christof M., van Vuurden, Dannis G., Hulleman, Esther, Janssens, Geert O., Solanki, Guirish A., van Veelen, Marie Luise C., Thomale, Ulrich, Schuhmann, Martin U., Jones, Chris, Giangaspero, Felice, Figarella-Branger, Dominique, Pietsch, Torsten, Clifford, Steve C., Pfister, Stefan M., and Van Gool, Stefaan W.

Published
2018

5. Biological material collection to advance translational research and treatment of children with CNS tumours : position paper from the SIOPE Brain Tumour Group

Author

Rutkowski, Stefan, Modena, Piergiorgio, Williamson, Daniel, Kerl, Kornelius, Nysom, Karsten, Pizer, Barry, Bartels, Ute, Puget, Stephanie, Doz, François, Michalski, Antony, von Hoff, Katja, Chevignard, Mathilde, Avula, Shivaram, Murray, Matthew J., Schönberger, Stefan, Czech, Thomas, Schouten-van Meeteren, Antoinette Y.N., Kordes, Uwe, Kramm, Christof M., van Vuurden, Dannis G., Hulleman, Esther, Janssens, Geert O., Solanki, Guirish A., van Veelen, Marie Luise C., Thomale, Ulrich, Schuhmann, Martin U., Jones, Chris, Giangaspero, Felice, Figarella-Branger, Dominique, Pietsch, Torsten, Clifford, Steve C., Pfister, Stefan M., Van Gool, Stefaan W., Rutkowski, Stefan, Modena, Piergiorgio, Williamson, Daniel, Kerl, Kornelius, Nysom, Karsten, Pizer, Barry, Bartels, Ute, Puget, Stephanie, Doz, François, Michalski, Antony, von Hoff, Katja, Chevignard, Mathilde, Avula, Shivaram, Murray, Matthew J., Schönberger, Stefan, Czech, Thomas, Schouten-van Meeteren, Antoinette Y.N., Kordes, Uwe, Kramm, Christof M., van Vuurden, Dannis G., Hulleman, Esther, Janssens, Geert O., Solanki, Guirish A., van Veelen, Marie Luise C., Thomale, Ulrich, Schuhmann, Martin U., Jones, Chris, Giangaspero, Felice, Figarella-Branger, Dominique, Pietsch, Torsten, Clifford, Steve C., Pfister, Stefan M., and Van Gool, Stefaan W.

Published
2018

6. Biological material collection to advance translational research and treatment of children with CNS tumours: position paper from the SIOPE Brain Tumour Group

Author

UMC Utrecht, MS Radiotherapie, Cancer, Rutkowski, Stefan, Modena, Piergiorgio, Williamson, Daniel, Kerl, Kornelius, Nysom, Karsten, Pizer, Barry, Bartels, Ute, Puget, Stephanie, Doz, François, Michalski, Antony, von Hoff, Katja, Chevignard, Mathilde, Avula, Shivaram, Murray, Matthew J., Schönberger, Stefan, Czech, Thomas, Schouten-van Meeteren, Antoinette Y.N., Kordes, Uwe, Kramm, Christof M., van Vuurden, Dannis G., Hulleman, Esther, Janssens, Geert O., Solanki, Guirish A., van Veelen, Marie Luise C., Thomale, Ulrich, Schuhmann, Martin U., Jones, Chris, Giangaspero, Felice, Figarella-Branger, Dominique, Pietsch, Torsten, Clifford, Steve C., Pfister, Stefan M., Van Gool, Stefaan W., UMC Utrecht, MS Radiotherapie, Cancer, Rutkowski, Stefan, Modena, Piergiorgio, Williamson, Daniel, Kerl, Kornelius, Nysom, Karsten, Pizer, Barry, Bartels, Ute, Puget, Stephanie, Doz, François, Michalski, Antony, von Hoff, Katja, Chevignard, Mathilde, Avula, Shivaram, Murray, Matthew J., Schönberger, Stefan, Czech, Thomas, Schouten-van Meeteren, Antoinette Y.N., Kordes, Uwe, Kramm, Christof M., van Vuurden, Dannis G., Hulleman, Esther, Janssens, Geert O., Solanki, Guirish A., van Veelen, Marie Luise C., Thomale, Ulrich, Schuhmann, Martin U., Jones, Chris, Giangaspero, Felice, Figarella-Branger, Dominique, Pietsch, Torsten, Clifford, Steve C., Pfister, Stefan M., and Van Gool, Stefaan W.

Published
2018

7. Pediatric intracranial ependymoma: correlating signs and symptoms at recurrence with outcome in the second prospective AIEOP protocol follow-up

Author

Massimino, Maura, Barretta, Francesco, Modena, Piergiorgio, Giangaspero, Felice, Chiapparini, Luisa, Erbetta, Alessandra, Boschetti, Luna, Antonelli, Manila, Ferroli, Paolo, Bertin, Daniele, Pecori, Emilia, Biassoni, Veronica, Garrè, Maria Luisa, Schiavello, Elisabetta, Sardi, Iacopo, Viscardi, Elisabetta, Scarzello, Giovanni, Mascarin, Maurizio, Quaglietta, Lucia, Cinalli, Giuseppe, Genitori, Lorenzo, Peretta, Paola, Mussano, Anna, Barra, Salvina, Mastronuzzi, Angela, Giussani, Carlo, Marras, Carlo Efisio, Balter, Rita, Bertolini, Patrizia, Tornesello, Assunta, La Spina, Milena, Buttarelli, Francesca Romana, Ruggiero, Antonio, Caldarelli, Massimo, Poggi, Geraldina, Gandola, Lorenza, Tornesello, Assunta (ORCID:0000-0002-7485-7440), Ruggiero, Antonio (ORCID:0000-0002-6052-3511), Caldarelli, Massimo (ORCID:0000-0002-2111-3800), Massimino, Maura, Barretta, Francesco, Modena, Piergiorgio, Giangaspero, Felice, Chiapparini, Luisa, Erbetta, Alessandra, Boschetti, Luna, Antonelli, Manila, Ferroli, Paolo, Bertin, Daniele, Pecori, Emilia, Biassoni, Veronica, Garrè, Maria Luisa, Schiavello, Elisabetta, Sardi, Iacopo, Viscardi, Elisabetta, Scarzello, Giovanni, Mascarin, Maurizio, Quaglietta, Lucia, Cinalli, Giuseppe, Genitori, Lorenzo, Peretta, Paola, Mussano, Anna, Barra, Salvina, Mastronuzzi, Angela, Giussani, Carlo, Marras, Carlo Efisio, Balter, Rita, Bertolini, Patrizia, Tornesello, Assunta, La Spina, Milena, Buttarelli, Francesca Romana, Ruggiero, Antonio, Caldarelli, Massimo, Poggi, Geraldina, Gandola, Lorenza, Tornesello, Assunta (ORCID:0000-0002-7485-7440), Ruggiero, Antonio (ORCID:0000-0002-6052-3511), and Caldarelli, Massimo (ORCID:0000-0002-2111-3800)

Abstract

Purpose The aims of patients’ radiological surveillance are to: ascertain relapse; apply second-line therapy; accrue patients in phase 1/2 protocols if second-line therapy is not standardized/curative; and assess/treat iatrogenic effects. To lessen the emotional and socioeconomic burdens for patients and families, we ideally need to establish whether scheduled radiological surveillance gives patients a better outcome than waiting for symptoms and signs to appear. Methods We analyzed a prospective series of 160 newly-diagnosed and treated pediatric/adolescent patients with intracranial ependymoma, comparing patients with recurrent disease identified on scheduled MRI (the RECPT group; 34 cases) with those showing signs/symptoms of recurrent disease (the SYMPPT group; 16 cases). The median follow-up was 67 months. Results No significant differences emerged between the two groups in terms of gender, age, tumor grade/site, shunting, residual disease, or type of relapse (local, distant, or concomitant). The time to relapse (median 19 months; range 5–104) and the MRI follow-up intervals did not differ between the SYMPPT and RECPT groups. The presence of signs/symptoms was an unfavorable factor for overall survival (OS) after recurrence (5-year OS: 8% vs. 37%, p = 0.001). On multivariable analysis, an adjusted model confirmed a significantly worse OS in the SYMPPT than in the RECPT patients. Conclusions Symptomatic relapses carried a significantly worse survival for ependymoma patients than recurrences detected by MRI alone. It would therefore be desirable to identify recurrences before symptoms develop. Radiological follow-up should be retained in ependymoma patient surveillance because there is a chance of salvage treatment for relapses found on MRI.

Published
2018

Catalog

Books, media, physical & digital resources
See catalog results