5 results on '"Monsef N"'
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2. A Nation-Wide Population-Based Mapping of Targetable Alterations in Smoking-Independent Lung Cancer
- Author
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Salomonsson, A., Patthey, A., Reutersward, C., Jonsson, M., Botling, Johan, Brunnstrom, H., Hussein, A., Monsef, N., Ortiz-Villalon, C., Bergman, B., De Petris, L., Lamberg, Kristina, Viltstrom, A., Wagenius, G., Behndig, A., Brandén, Eva, Johansson, M., Koyi, Hirsh, Staaf, J., Planck, M., Salomonsson, A., Patthey, A., Reutersward, C., Jonsson, M., Botling, Johan, Brunnstrom, H., Hussein, A., Monsef, N., Ortiz-Villalon, C., Bergman, B., De Petris, L., Lamberg, Kristina, Viltstrom, A., Wagenius, G., Behndig, A., Brandén, Eva, Johansson, M., Koyi, Hirsh, Staaf, J., and Planck, M.
- Published
- 2018
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3. A Nation-Wide Population-Based Mapping of Targetable Alterations in Smoking-Independent Lung Cancer
- Author
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Salomonsson, A., Patthey, Annika, Reuterswärd, C., Jönsson, M., Botling, J., Brunnström, H., Hussein, A., Monsef, N., Ortiz-Villalon, C., Bergman, B., De Petris, L., Lamberg, K., Vikström, A., Wagenius, G., Behndig, Annelie F., Brandén, E., Johansson, Mikael, Koyi, H., Staaf, J., Planck, M., Salomonsson, A., Patthey, Annika, Reuterswärd, C., Jönsson, M., Botling, J., Brunnström, H., Hussein, A., Monsef, N., Ortiz-Villalon, C., Bergman, B., De Petris, L., Lamberg, K., Vikström, A., Wagenius, G., Behndig, Annelie F., Brandén, E., Johansson, Mikael, Koyi, H., Staaf, J., and Planck, M.
- Abstract
Background: Smoking is by far the most important cause of lung cancer. However, lung cancer among never-smokers is common and increasing [1]. A smoking-independent subgroup of lung adenocarcinoma with certain molecular and clinical features exists [2-3]. Therefore, as 1st project within the Swedish Molecular Initiative against Lung cancer (SMIL) we aim to characterize never-smoking lung cancer for etiological, diagnostic and therapeutic purposes. Method: Through the Swedish National Lung Cancer Registry [1], we identified all individuals who underwent surgery for lung cancer in Sweden 2005-2014 and who were registered as never-smokers (n=540). At each study site (n=6), clinical data were reviewed by a thoracic oncologist/pulmonologist through patients' medical charts and archived tumor tissues were retrieved and reviewed by a thoracic pathologist. For subsequent studies, we extracted DNA and RNA (using the Qiagen AllPrep kit for FFPE tissue) and constructed tissue microarrays. As a first pre-planned analysis, we performed fusion gene mapping using an RNA-based NanoString nCounter Elements assay, as previously described [4]. Result: In the first 212 (out of 540) analyzed samples, we detected 17 fusions involving ALK, 8 involving RET, and 2 involving NRG1. In addition, MET exon 14 skipping was found in 17 samples. In total, these findings involved 21% of analyzed cases. Additional results from further studies on the cohort will be presented. Conclusion: SMIL is an ongoing nation-wide molecular research collaboration on lung cancer where we currently collect one of the largest never-smoking lung tumor cohorts worldwide. From the first pre-planned analyses, we conclude that, in a population-based cohort of early stage lung cancer from never-smokers, druggable oncogenic fusions are frequent.
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- 2018
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4. Inequalities in the use of secondary prevention of cardiovascular disease by socioeconomic status: evidence from the PURE observational study
- Author
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Murphy, A. (Adrianna), Palafox, B. (Benjamin), O'Donnell, O.A. (Owen), Stuckler, D. (David), Perel, P. (Pablo), AlHabib, K.F. (Khalid F), Avezum, A. (Alvaro), Bai, X. (Xiulin), Chifamba, J. (Jephat), Chow, C.K. (Clara K), Corsi, D.J. (Daniel J), Dagenais, G.R. (Gilles R), Dans, A.L. (Antonio L), Díaz, R. (Rafael), Erbakan, A.N. (Ayse N), Ismail, N. (Noorhassim), Iqbal, R. (Romaina), Kelishadi, R. (Roya), Khatib, R. (Rasha), Lanas, F. (Fernando), Lear, S.A. (Scott A), Li, W. (Wei), Liu, J. (Jia), Lopez-Jaramillo, P. (Patricio), Mohan, V. (Viswanathan), Monsef, N. (Nahed), Mony, P.K. (Prem K), Puoane, T. (Thandi), Rangarajan, S. (Sumathy), Rosengren, A. (Annika), Schutte, A.E. (Aletta E), Sintaha, M. (Mariz), Teo, K.K. (Koon K), Wielgosz, A. (Andreas), Yeates, K. (Karen), Yin, L. (Lu), Yusoff, K. (Khalid), Zatońska, K. (Katarzyna), Yusuf, S. (Salim), McKee, M. (Martin), Murphy, A. (Adrianna), Palafox, B. (Benjamin), O'Donnell, O.A. (Owen), Stuckler, D. (David), Perel, P. (Pablo), AlHabib, K.F. (Khalid F), Avezum, A. (Alvaro), Bai, X. (Xiulin), Chifamba, J. (Jephat), Chow, C.K. (Clara K), Corsi, D.J. (Daniel J), Dagenais, G.R. (Gilles R), Dans, A.L. (Antonio L), Díaz, R. (Rafael), Erbakan, A.N. (Ayse N), Ismail, N. (Noorhassim), Iqbal, R. (Romaina), Kelishadi, R. (Roya), Khatib, R. (Rasha), Lanas, F. (Fernando), Lear, S.A. (Scott A), Li, W. (Wei), Liu, J. (Jia), Lopez-Jaramillo, P. (Patricio), Mohan, V. (Viswanathan), Monsef, N. (Nahed), Mony, P.K. (Prem K), Puoane, T. (Thandi), Rangarajan, S. (Sumathy), Rosengren, A. (Annika), Schutte, A.E. (Aletta E), Sintaha, M. (Mariz), Teo, K.K. (Koon K), Wielgosz, A. (Andreas), Yeates, K. (Karen), Yin, L. (Lu), Yusoff, K. (Khalid), Zatońska, K. (Katarzyna), Yusuf, S. (Salim), and McKee, M. (Martin)
- Abstract
Background: There is little evidence on the use of secondary prevention medicines for cardiovascular disease by socioeconomic groups in countries at different levels of economic development. Methods: We assessed use of antiplatelet, cholesterol, and blood-pressure-lowering drugs in 8492 individuals with self-reported cardiovascular disease from 21 countries enrolled in the Prospective Urban Rural Epidemiology (PURE) study. Defining one or more drugs as a minimal level of secondary prevention, wealth-related inequality was measured using the Wagstaff concentration index, scaled from −1 (pro-poor) to 1 (pro-rich), standardised by age and sex. Correlations between inequalities and national health-related indicators were estimated. Findings: The proportion of patients with cardiovascular disease on three medications ranged from 0% in South Africa (95% CI 0–1·7), Tanzania (0–3·6), and Zimbabwe (0–5·1), to 49·3% in Canada (44·4–54·3). Proportions receiving at least one drug varied from 2·0% (95% CI 0·5–6·9) in Tanzania to 91·4% (86·6–94·6) in Sweden. There was significant (p<0·05) pro-rich inequality in Saudi Arabia, China, Colombia, India, Pakistan, and Zimbabwe. Pro-poor distributions were observed in Sweden, Brazil, Chile, Poland, and the occupied Palestinian territory. The strongest predictors of inequality were public expenditure on health and overall use of secondary prevention medicines. Interpretation: Use of medication for secondary prevention of cardiovascular disease is alarmingly low. In many countries with the lowest use, pro-rich inequality is greatest. Policies associated with an equal or pro-poor distribution include free medications and community health programmes to support adherence to medications. Funding: Full funding sources listed at the end of the paper (see Acknowledgments).
- Published
- 2018
- Full Text
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5. Inequalities in the use of secondary prevention of cardiovascular disease by socioeconomic status: evidence from the PURE observational study
- Author
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Murphy, A, Palafox, B, O'Donnell, Owen, Stuckler, D, Perel, P, AlHabib, KF, Avezum, A, Bai, XL, Chifamba, J, Chow, CK, Corsi, DJ, Dagenais, GR, Dans, AL, Diaz, R, Erbakan, AN, Ismail, N, Iqbal, R, Kelishadi, R, Khatib, R, Lanas, F, Lear, SA, Li, W, Liu, J, Lopez-Jaramillo, P, Mohan, V, Monsef, N, Mony, PK, Puoane, T, Rangarajan, S, Rosengren, A, Schutte, AEM, Sintaha, M, Teo, KK, Wielgosz, A, Yeates, K, Yin, L, Yusoff, K, Zatonska, K, Yusuf, S, McKee, M, Murphy, A, Palafox, B, O'Donnell, Owen, Stuckler, D, Perel, P, AlHabib, KF, Avezum, A, Bai, XL, Chifamba, J, Chow, CK, Corsi, DJ, Dagenais, GR, Dans, AL, Diaz, R, Erbakan, AN, Ismail, N, Iqbal, R, Kelishadi, R, Khatib, R, Lanas, F, Lear, SA, Li, W, Liu, J, Lopez-Jaramillo, P, Mohan, V, Monsef, N, Mony, PK, Puoane, T, Rangarajan, S, Rosengren, A, Schutte, AEM, Sintaha, M, Teo, KK, Wielgosz, A, Yeates, K, Yin, L, Yusoff, K, Zatonska, K, Yusuf, S, and McKee, M
- Published
- 2018
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