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1. Changes in PD-1- and CTLA-4-bearing blood lymphocytes in ICU COVID-19 patients treated with Favipiravir/Kaletra or Dexamethasone/Remdesivir: a pilot study

Author

Mortaz, Esmaeil, Jamaati, Hamidreza, K Dezfuli, Neda, Sheikhzade, Hakime, Hashemian, Seyed MohammadReza, Roofchayee, Neda Dalil, Dastan, Frazaneh, Tabarsi, Payam, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, Adcock, Ian M, Mortaz, Esmaeil, Jamaati, Hamidreza, K Dezfuli, Neda, Sheikhzade, Hakime, Hashemian, Seyed MohammadReza, Roofchayee, Neda Dalil, Dastan, Frazaneh, Tabarsi, Payam, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, and Adcock, Ian M

Abstract

COVID-19, caused by SARS-CoV-2, requires new approaches to control the disease. Programmed cell death protein (PD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) play important roles in T-cell exhaustion in severe COVID-19. This study evaluated the frequency of whole blood lymphocytes expressing PD-1 and CTLA-4 in COVID-19 patients upon admission to the intensive care unit (ICU) (i.e., severe) or infection ward (i.e., moderate) and after 7 days of antiviral therapy. COVID-19 patients were treated with either favipiravir or Kaletra (FK group, 11 severe and 11 moderate) or dexamethasone plus remdesivir (DR group, 7 severe and 10 moderate) for 7 days in a pilot study. Eight healthy control subjects were also enrolled. The frequency of PD-1+ and CTLA-4+ lymphocytes in whole blood was evaluated by flow cytometry. Patients on DR therapy had shorter hospital stays than those on FK therapy. The frequency of PD-1+ lymphocytes in the FK group at baseline differed between COVID-19 patients and healthy controls, while the frequency of both PD-1+ and CTLA-4+ cells increased significantly 7 days of FK therapy. The response was similar in both moderate and severe patients. In contrast, the frequency of PD-1+ and CTLA-4+ lymphocytes varied significantly between patients and healthy controls before DR treatment. DR therapy enhanced PD-1+ but not the CTLA-4+ frequency of these cells after 7 days. We show that the frequency of PD-1 and CTAL-4-bearing lymphocytes during hospitalization was increased in Iranian ICU COVID-19 patients who received FK treatment, but that the frequency of CTLA-4+ cells was higher at baseline and did not increase in patients who received DR. The effectiveness of DR treatment may reflect differences in T-cell activation or exhaustion status, particularly in CTLA-4-expressing cells.

Published
2023

2. Changes in PD-1- and CTLA-4-bearing blood lymphocytes in ICU COVID-19 patients treated with Favipiravir/Kaletra or Dexamethasone/Remdesivir: a pilot study

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Jamaati, Hamidreza, K Dezfuli, Neda, Sheikhzade, Hakime, Hashemian, Seyed MohammadReza, Roofchayee, Neda Dalil, Dastan, Frazaneh, Tabarsi, Payam, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Jamaati, Hamidreza, K Dezfuli, Neda, Sheikhzade, Hakime, Hashemian, Seyed MohammadReza, Roofchayee, Neda Dalil, Dastan, Frazaneh, Tabarsi, Payam, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, and Adcock, Ian M

Published
2023

3. Changes in PD-1- and CTLA-4-bearing blood lymphocytes in ICU COVID-19 patients treated with Favipiravir/Kaletra or Dexamethasone/Remdesivir: a pilot study

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Jamaati, Hamidreza, K Dezfuli, Neda, Sheikhzade, Hakime, Hashemian, Seyed MohammadReza, Roofchayee, Neda Dalil, Dastan, Frazaneh, Tabarsi, Payam, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Jamaati, Hamidreza, K Dezfuli, Neda, Sheikhzade, Hakime, Hashemian, Seyed MohammadReza, Roofchayee, Neda Dalil, Dastan, Frazaneh, Tabarsi, Payam, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, and Adcock, Ian M

Published
2023

4. Decreased serum levels of angiotensin converting enzyme (ACE)2 and enhanced cytokine levels with severity of COVID-19: normalisation upon disease recovery

Author

Mortaz, Esmaeil, Jamaati, Hamidreza, Roofchayee, Neda Dalil, Sheikhzade, Hakime, Mirenayat, Maryam, Sadeghi, Mohsen, Lookzadeh, Somayeh, Dezfuli, Neda K, Folkerts, Gert, Mumby, Sharon, Garssen, Johan, Adcock, Ian M, Mortaz, Esmaeil, Jamaati, Hamidreza, Roofchayee, Neda Dalil, Sheikhzade, Hakime, Mirenayat, Maryam, Sadeghi, Mohsen, Lookzadeh, Somayeh, Dezfuli, Neda K, Folkerts, Gert, Mumby, Sharon, Garssen, Johan, and Adcock, Ian M

Abstract

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19). Circulating soluble angiotensin-converting enzyme (sACE2)2, the main receptor for SARS-CoV-2, together with components of the renin-angiotensin system promote infection and disease severity.Objective: This pilot study followed the time-course of sACE2 levels in relation to systemic cytokines in severe and moderate COVID-19 patients treated with remdesivir/dexamethasone in combination.Methods: Peripheral blood was obtained upon admission from 30 patients (12 with moderate disease and 18 with severe disease) and 14 patients with PCR-confirmed mild COVID-19. Severe and moderate patients were treated with remdesivir (200mg/first day and 100mg/day for the remaining days) and dexamethasone (100mg/day). 6 healthy control subjects (HC) were also enrolled. Serum interleukin (IL)-6 and IL-8 and sACE2 levels were measured by ELISA at baseline and during treatment in severe and moderate patients and at baseline in mild and HCs.Results: Baseline sACE2 levels were lower in severe (p = 0.0005) and moderate (p = 0.0022) patients than in patients with mild COVID-19 and in HC (p = 0.0023 and p = 0.0012 respectively). Treatment significantly increased sACE2 levels in patients with moderate disease (p = 0.0156) but only 50% of patients with severe disease showed enhanced levels compared to baseline. Systemic IL-6 and IL-8 levels were higher in all patient groups compared with HC and were not significantly affected over time or by remdesivir/dexamethasone treatment for 5 days.Conclusion: Serum sACE2 levels increase in severe COVID-19 patients as they recover over time whilst circulating cytokines are unaffected. Future studies should link these results to clinical outcomes.

Published
2022

5. Decreased serum levels of angiotensin converting enzyme (ACE)2 and enhanced cytokine levels with severity of COVID-19: normalisation upon disease recovery

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Jamaati, Hamidreza, Roofchayee, Neda Dalil, Sheikhzade, Hakime, Mirenayat, Maryam, Sadeghi, Mohsen, Lookzadeh, Somayeh, Dezfuli, Neda K, Folkerts, Gert, Mumby, Sharon, Garssen, Johan, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Jamaati, Hamidreza, Roofchayee, Neda Dalil, Sheikhzade, Hakime, Mirenayat, Maryam, Sadeghi, Mohsen, Lookzadeh, Somayeh, Dezfuli, Neda K, Folkerts, Gert, Mumby, Sharon, Garssen, Johan, and Adcock, Ian M

Published
2022

6. Decreased serum levels of angiotensin converting enzyme (ACE)2 and enhanced cytokine levels with severity of COVID-19: normalisation upon disease recovery

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Jamaati, Hamidreza, Roofchayee, Neda Dalil, Sheikhzade, Hakime, Mirenayat, Maryam, Sadeghi, Mohsen, Lookzadeh, Somayeh, Dezfuli, Neda K, Folkerts, Gert, Mumby, Sharon, Garssen, Johan, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Jamaati, Hamidreza, Roofchayee, Neda Dalil, Sheikhzade, Hakime, Mirenayat, Maryam, Sadeghi, Mohsen, Lookzadeh, Somayeh, Dezfuli, Neda K, Folkerts, Gert, Mumby, Sharon, Garssen, Johan, and Adcock, Ian M

Published
2022

7. Decreased serum levels of angiotensin converting enzyme (ACE)2 and enhanced cytokine levels with severity of COVID-19: normalisation upon disease recovery

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Jamaati, Hamidreza, Roofchayee, Neda Dalil, Sheikhzade, Hakime, Mirenayat, Maryam, Sadeghi, Mohsen, Lookzadeh, Somayeh, Dezfuli, Neda K, Folkerts, Gert, Mumby, Sharon, Garssen, Johan, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Jamaati, Hamidreza, Roofchayee, Neda Dalil, Sheikhzade, Hakime, Mirenayat, Maryam, Sadeghi, Mohsen, Lookzadeh, Somayeh, Dezfuli, Neda K, Folkerts, Gert, Mumby, Sharon, Garssen, Johan, and Adcock, Ian M

Published
2022

8. Association of Differential Mast Cell Activation with Granulocytic Inflammation in Severe Asthma

Author

Tiotiu, Angelica, Badi, Yusef, Kermani, Nazanin Zounemat, Sanak, Marek, Kolmert, Johan, Wheelock, Craig E., Hansbro, Philip M., Dahlén, Sven-Erik, Sterk, Peter J., Djukanovic, Ratko, Guo, Yike, Mumby, Sharon, U-BIOPRED Consortium Project Team, Tiotiu, Angelica, Badi, Yusef, Kermani, Nazanin Zounemat, Sanak, Marek, Kolmert, Johan, Wheelock, Craig E., Hansbro, Philip M., Dahlén, Sven-Erik, Sterk, Peter J., Djukanovic, Ratko, Guo, Yike, Mumby, Sharon, and U-BIOPRED Consortium Project Team

Abstract

Rationale: Mast cells (MCs) play a role in inflammation and both innate and adaptive immunity, but their involvement in severe asthma (SA) remains undefined. Objectives: We investigated the phenotypic characteristics of the U-BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Diseases Outcomes) asthma cohort by applying published MC activation signatures to the sputum cell transcriptome. Methods: Eighty-four participants with SA, 20 with mild/moderate asthma (MMA), and 16 healthy participants without asthma were studied. We calculated enrichment scores (ESs) for nine MC activation signatures by asthma severity, sputum granulocyte status, and three previously defined sputum molecular phenotypes or transcriptome-associated clusters (TACs) 1, 2, and 3 using gene set variation analysis. Measurements and Main Results: MC signatures except unstimulated, repeated FceR1-stimulated and IFN-g–stimulated signatures were enriched in SA. A FceR1-IgE–stimulated and a single-cell signature from asthmatic bronchial biopsies were highly enriched in eosinophilic asthma and in the TAC1 molecular phenotype. Subjects with a high ES for these signatures had elevated sputum amounts of similar genes and pathways. IL-33– and LPS-stimulated MC signatures had greater ES in neutrophilic and mixed granulocytic asthma and in the TAC2 molecular phenotype. These subjects exhibited neutrophil, NF-kB (nuclear factor-kB), and IL-1b/TNF-a (tumor necrosis factor-a) pathway activation. The IFN-g–stimulated signature had the greatest ES in TAC2 and TAC3 that was associated with responses to viral infection. Similar results were obtained in an independent ADEPT (Airway Disease Endotyping for Personalized Therapeutics) asthma cohort. Conclusions: Gene signatures of MC activation allow the detection of SA phenotypes and indicate that MCs can be induced to take on distinct transcriptional phenotypes associated with specific clinical phenotypes. IL-33–stimulated MC signature was associated with se

Published
2022

9. Nutritional Impact and Its Potential Consequences on COVID-19 Severity

Author

Mortaz, Esmaeil, Bezemer, Gillina, Alipoor, Shamila D, Varahram, Mohammad, Mumby, Sharon, Folkerts, Gert, Garssen, Johan, Adcock, Ian M, Mortaz, Esmaeil, Bezemer, Gillina, Alipoor, Shamila D, Varahram, Mohammad, Mumby, Sharon, Folkerts, Gert, Garssen, Johan, and Adcock, Ian M

Abstract

Background: During late 2019 a viral disease due to a novel coronavirus was reported in Wuhan, China, which rapidly developed into an exploding pandemic and poses a severe threat to human health all over the world. Until now (May 2021), there are insufficient treatment options for the management of this global disease and shortage of vaccines. Important aspects that help to defeat coronavirus infection seems to be having a healthy, strong, and resilient immune system. Nutrition and metabolic disorders, such as obesity and diabetes play a crucial role on the community health situation in general and especially during this new pandemic. There seems to be an enormous impact of lifestyle, metabolic disorders, and immune status on coronavirus disease 2019 (COVID-19) severity and recovery. For this reason, it is important to consider the impact of lifestyle and the consumption of well-defined healthy diets during the pandemic. Aims: In this review, we summarise recent findings on the effect of nutrition on COVID-19 susceptibility and disease severity and treatment. Understanding how specific dietary features might help to improve the public health strategies to reduce the rate and severity of COVID-19.

Published
2021

10. Nutritional Impact and Its Potential Consequences on COVID-19 Severity

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Bezemer, Gillina, Alipoor, Shamila D, Varahram, Mohammad, Mumby, Sharon, Folkerts, Gert, Garssen, Johan, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Bezemer, Gillina, Alipoor, Shamila D, Varahram, Mohammad, Mumby, Sharon, Folkerts, Gert, Garssen, Johan, and Adcock, Ian M

Published
2021

11. Nutritional Impact and Its Potential Consequences on COVID-19 Severity

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Bezemer, Gillina, Alipoor, Shamila D, Varahram, Mohammad, Mumby, Sharon, Folkerts, Gert, Garssen, Johan, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Bezemer, Gillina, Alipoor, Shamila D, Varahram, Mohammad, Mumby, Sharon, Folkerts, Gert, Garssen, Johan, and Adcock, Ian M

Published
2021

12. Nutritional Impact and Its Potential Consequences on COVID-19 Severity

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Bezemer, Gillina, Alipoor, Shamila D, Varahram, Mohammad, Mumby, Sharon, Folkerts, Gert, Garssen, Johan, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Bezemer, Gillina, Alipoor, Shamila D, Varahram, Mohammad, Mumby, Sharon, Folkerts, Gert, Garssen, Johan, and Adcock, Ian M

Published
2021

13. Type 2-low asthma phenotypes by integration of sputum transcriptomics and serum proteomics

Author

U-BIOPRED Project, Team, Zounemat Kermani, Nazanin, Saqi, Mansoor, Agapow, Paul, Pavlidis, Stelios, Kuo, Chihhsi, Tan, Kai Sen, Mumby, Sharon, Sun, Kai, Loza, Matthew, Baribaud, Frederic, Sousa, Ana R., Riley, John, Wheelock, Asa M., Wheelock, Craig E., De Meulder, Bertrand, Schofield, Jim, Sánchez-Ovando, Stephany, Simpson, Jodie Louise, Baines, Katherine Joanne, Wark, Peter A., Auffray, Charles, Dahlen, Sven-Erik, Sterk, Peter J., Djukanovic, Ratko, Adcock, Ian M., Guo, Yike, Chung, Kian Fan, U-BIOPRED Project, Team, Zounemat Kermani, Nazanin, Saqi, Mansoor, Agapow, Paul, Pavlidis, Stelios, Kuo, Chihhsi, Tan, Kai Sen, Mumby, Sharon, Sun, Kai, Loza, Matthew, Baribaud, Frederic, Sousa, Ana R., Riley, John, Wheelock, Asa M., Wheelock, Craig E., De Meulder, Bertrand, Schofield, Jim, Sánchez-Ovando, Stephany, Simpson, Jodie Louise, Baines, Katherine Joanne, Wark, Peter A., Auffray, Charles, Dahlen, Sven-Erik, Sterk, Peter J., Djukanovic, Ratko, Adcock, Ian M., Guo, Yike, and Chung, Kian Fan

Published
2021

14. Does Neutrophil Phenotype Predict the Survival of Trauma Patients?

Author

Mortaz, Esmaeil, Zadian, Seyed Sajjad, Shahir, Mehri, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, Adcock, Ian M., Mortaz, Esmaeil, Zadian, Seyed Sajjad, Shahir, Mehri, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, and Adcock, Ian M.

Abstract

According to the World Health Organization (WHO), trauma is responsible for 10% of deaths and 16% of disabilities worldwide. This is considerably higher than those for malaria, tuberculosis, and HIV/AIDS combined. While the human suffering and death caused by injury is well-recognized, injury has a significant medical care cost. Better prediction of the state of trauma patients in the days immediately after trauma may reduce costs. Traumatic injuries to multiple organs can cause dysfunction in all systems of the body especially the immune system placing patients at high risk of infections and inflammatory complications which are often fatal. Neutrophils are the most abundant leukocyte in the human circulation and are crucial for the prevention of microbial disease. Significant changes in neutrophil functions such as enhanced chemotaxis, Neutrophil extracellular trap (NET)-induced cell death (NETosis), and phagocytosis occur early after injury followed by prolonged functional defects such as phagocytosis, killing mechanisms, and receptor expression. Analysis of these changes may improve the prediction of the patient's condition over time. We provide a comprehensive and up-to-date review of the literature investigating the effect of trauma on neutrophil phenotype with an underlying goal of using this knowledge to examine the predictive potential of neutrophil alterations on secondary complications in patients with traumatic injuries. We conclude that alterations in neutrophil surface markers and functions may be potential biomarkers that predict the outcome of trauma patients.

Published
2019

15. Does Neutrophil Phenotype Predict the Survival of Trauma Patients?

Author

Mortaz, Esmaeil, Zadian, Seyed Sajjad, Shahir, Mehri, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, Adcock, Ian M., Mortaz, Esmaeil, Zadian, Seyed Sajjad, Shahir, Mehri, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, and Adcock, Ian M.

Published
2019

16. Does Neutrophil Phenotype Predict the Survival of Trauma Patients?

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Zadian, Seyed Sajjad, Shahir, Mehri, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, Adcock, Ian M., Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Zadian, Seyed Sajjad, Shahir, Mehri, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, and Adcock, Ian M.

Published
2019

17. Does Neutrophil Phenotype Predict the Survival of Trauma Patients?

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Zadian, Seyed Sajjad, Shahir, Mehri, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, Adcock, Ian M., Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Zadian, Seyed Sajjad, Shahir, Mehri, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, and Adcock, Ian M.

Published
2019

18. Does Neutrophil Phenotype Predict the Survival of Trauma Patients?

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Zadian, Seyed Sajjad, Shahir, Mehri, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, Adcock, Ian M., Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Zadian, Seyed Sajjad, Shahir, Mehri, Folkerts, Gert, Garssen, Johan, Mumby, Sharon, and Adcock, Ian M.

Published
2019

19. Bacterial load and inflammatory response in sputum of alpha-1 antitrypsin deficiency patients with COPD

Author

Balbi,Bruno, Sangiorgi,Claudia, Gnemmi,Isabella, Ferrarotti,Ilaria, Vallese,Davide, Paracchini,Elena, Delle Donne,Lorena, Corda,Luciano, Baderna,Paolo, Corsico,Angelo, Carone,Mauro, Brun,Paola, Cappello,Francesco, Ricciardolo,Fabio LM, Ruggeri,Paolo, Mumby,Sharon, Adcock,Ian M, Caramori,Gaetano, Di Stefano,Antonino, Balbi,Bruno, Sangiorgi,Claudia, Gnemmi,Isabella, Ferrarotti,Ilaria, Vallese,Davide, Paracchini,Elena, Delle Donne,Lorena, Corda,Luciano, Baderna,Paolo, Corsico,Angelo, Carone,Mauro, Brun,Paola, Cappello,Francesco, Ricciardolo,Fabio LM, Ruggeri,Paolo, Mumby,Sharon, Adcock,Ian M, Caramori,Gaetano, and Di Stefano,Antonino

Abstract

Bruno Balbi,1 Claudia Sangiorgi,1 Isabella Gnemmi,1 Ilaria Ferrarotti,2 Davide Vallese,1 Elena Paracchini,1 Lorena Delle Donne,1 Luciano Corda,3 Paolo Baderna,4 Angelo Corsico,2 Mauro Carone,1 Paola Brun,5 Francesco Cappello,6,7 Fabio LM Ricciardolo,8 Paolo Ruggeri,9 Sharon Mumby,10 Ian M Adcock,10 Gaetano Caramori,9 Antonino Di Stefano11Istituti Clinici Scientifici Maugeri, IRCCS, Division of Pneumology and Laboratory of Cytoimmunopathology of the Heart and Lung, Veruno, Italy; 2Department of Internal Medicine and Medical Therapy, University of Pavia, Pavia, Italy; 3Medicina Respiratoria, Seconda Medicina Interna, Spedali Civili, Brescia, Italy; 4Division of Pneumology, Aosta Hospital, Aosta, Italy; 5Department of Molecular Medicine, University of Padova, Padova, Italy; 6Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Anatomia Umana, Università di Palermo, Palermo, Italy; 7Euro-mediterranean Institute of Science and Technology (IEMEST), Palermo, Italy; 8Department of Clinical and Biological Sciences, A.O.U., San Luigi Gonzaga, Orbassano, University of Turin, Turin, Italy; 9UOC Di Pneumologia, Dipartimento di Scienze Biomediche, Odontoiatriche e Delle Immagini Morfologiche e Funzionali (BIOMORF), Università di Messina, Messina, Italy; 10Airways Disease Section, National Heart and Lung Institute, Imperial College London, UKCorrespondence: Antonino Di StefanoIstituti Clinici Scientifici Maugeri Irccs, Via Maugeri, 4, Pavia 27100, ItalyTel +39 032 288 4711Fax +39 032 288 4776Email antonino.distefano@icsmaugeri.itBackground: Airway inflammation may drive the progression of chronic obstructive pulmonary disease (COPD) associated with alpha-1 antitrypsin deficiency (AATD), but the relationship between airway microbiota and inflammation has not been investigated.Methods: We studied 21 non-treated AATD (AATD-noT) patients, 20 AATD-COPD patients under augmentation therapy (AATD-AT), 20 cigarette smoke-associated COPD patient

Published
2019

20. Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation

Author

Mortaz, Esmaeil, Amani, Saeede, Mumby, Sharon, Adcock, Ian M, Movassaghi, Mehrnaz, Folkerts, Jelle, Garssen, Johan, Folkerts, Gert, Mortaz, Esmaeil, Amani, Saeede, Mumby, Sharon, Adcock, Ian M, Movassaghi, Mehrnaz, Folkerts, Jelle, Garssen, Johan, and Folkerts, Gert

Abstract

The multifunctional role of mast cells (MCs) in the immune system is complex and has not fully been explored. MCs reside in tissues and mucous membranes such as the lung, digestive tract, and skin which are strategically located at interfaces with the external environment. These cells, therefore, will encounter external stimuli and pathogens. MCs modulate both the innate and the adaptive immune response in inflammatory disorders including transplantation. MCs can have pro- and anti-inflammatory functions, thereby regulating the outcome of lung transplantation through secretion of mediators that allow interaction with other cell types, particularly innate lymphoid cells (ILC2). ILC2 cells are a unique population of hematopoietic cells that coordinate the innate immune response against a variety of threats including infection, tissue damage, and homeostatic disruption. In addition, MCs can modulate alloreactive T cell responses or assist in T regulatory (Treg) cell activity. This paper outlines the current understanding of the role of MCs in lung transplantation, with a specific focus on their interaction with ILC2 cells within the engrafted organ.

Published
2018

21. Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy

Author

Mortaz, Esmaeil, Alipoor, Shamila D, Varahram, Mohammad, Jamaati, Hamidreza, Garssen, Johan, Mumby, Sharon E, Adcock, Ian M, Mortaz, Esmaeil, Alipoor, Shamila D, Varahram, Mohammad, Jamaati, Hamidreza, Garssen, Johan, Mumby, Sharon E, and Adcock, Ian M

Abstract

Exosomes are nanosized vesicles and have recently been recognized as important players in cell-to-cell communication. Exosomes contain different mediators such as proteins, nucleic acids (DNA, mRNA, miRNAs, and other ncRNAs), and lipid mediators and can shuttle their exosomal content to both neighboring and distal cells. Exosomes are very effective in orchestrating immune responses in the airways and all cell types can contribute to the systemic exosome pool. Intracellular communication between the broad range of cell types within the lung is crucial in disease emphasizing the importance of exosomes. In asthma, exosomes affect the inflammatory microenvironment which ultimately determines the development or alleviation of the pathological symptoms. Recent studies in this area have provided insight into the underlying mechanisms of disease and led to interest in using exosomes as potential novel therapeutic agents.

Published
2018

23. Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Amani, Saeede, Mumby, Sharon, Adcock, Ian M, Movassaghi, Mehrnaz, Folkerts, Jelle, Garssen, Johan, Folkerts, Gert, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Amani, Saeede, Mumby, Sharon, Adcock, Ian M, Movassaghi, Mehrnaz, Folkerts, Jelle, Garssen, Johan, and Folkerts, Gert

Published
2018

24. Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Alipoor, Shamila D, Varahram, Mohammad, Jamaati, Hamidreza, Garssen, Johan, Mumby, Sharon E, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Alipoor, Shamila D, Varahram, Mohammad, Jamaati, Hamidreza, Garssen, Johan, Mumby, Sharon E, and Adcock, Ian M

Published
2018

27. Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Amani, Saeede, Mumby, Sharon, Adcock, Ian M, Movassaghi, Mehrnaz, Folkerts, Jelle, Garssen, Johan, Folkerts, Gert, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Amani, Saeede, Mumby, Sharon, Adcock, Ian M, Movassaghi, Mehrnaz, Folkerts, Jelle, Garssen, Johan, and Folkerts, Gert

Published
2018

28. Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Alipoor, Shamila D, Varahram, Mohammad, Jamaati, Hamidreza, Garssen, Johan, Mumby, Sharon E, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Alipoor, Shamila D, Varahram, Mohammad, Jamaati, Hamidreza, Garssen, Johan, Mumby, Sharon E, and Adcock, Ian M

Published
2018

29. Update on neutrophil function in severe inflammation

Author

Experimentele Afdeling Longziekten, Cancer, Infection & Immunity, Mortaz, Esmaeil, Alipoor, Shamila D., Adcock, Ian M., Mumby, Sharon, Koenderman, Leo, Experimentele Afdeling Longziekten, Cancer, Infection & Immunity, Mortaz, Esmaeil, Alipoor, Shamila D., Adcock, Ian M., Mumby, Sharon, and Koenderman, Leo

Published
2018

30. Exosomes in Severe Asthma: Update in Their Roles and Potential in Therapy

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Alipoor, Shamila D, Varahram, Mohammad, Jamaati, Hamidreza, Garssen, Johan, Mumby, Sharon E, Adcock, Ian M, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Alipoor, Shamila D, Varahram, Mohammad, Jamaati, Hamidreza, Garssen, Johan, Mumby, Sharon E, and Adcock, Ian M

Published
2018

31. Role of Mast Cells and Type 2 Innate Lymphoid (ILC2) Cells in Lung Transplantation

Author

Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Amani, Saeede, Mumby, Sharon, Adcock, Ian M, Movassaghi, Mehrnaz, Folkerts, Jelle, Garssen, Johan, Folkerts, Gert, Afd Pharmacology, Pharmacology, Mortaz, Esmaeil, Amani, Saeede, Mumby, Sharon, Adcock, Ian M, Movassaghi, Mehrnaz, Folkerts, Jelle, Garssen, Johan, and Folkerts, Gert

Published
2018

32. Sepsis 2016 Paris : Paris, France. 6-8 December 2016

Author

Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., Rocha, Maria José A, Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., and Rocha, Maria José A

Published
2016

33. Sepsis 2016 Paris : Paris, France. 6-8 December 2016

Author

Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., Rocha, Maria José A, Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., and Rocha, Maria José A

Published
2016

34. Sepsis 2016 Paris : Paris, France. 6-8 December 2016

Author

Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., Rocha, Maria José A, Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., and Rocha, Maria José A

Published
2016

35. Sepsis 2016 Paris: Paris, France. 6-8 December 2016

Author

Epi Infectieziekten Team 1, Infection & Immunity, Verpleegafd Vaatchirurgie D4 Oost, MS CGO, Cancer, Divisie Beeld & Oncologie, MMB, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., Rocha, Maria José A, Epi Infectieziekten Team 1, Infection & Immunity, Verpleegafd Vaatchirurgie D4 Oost, MS CGO, Cancer, Divisie Beeld & Oncologie, MMB, Epi Infectieziekten, JC onderzoeksprogramma Infectieziekten, Medische Staf Intensive Care, Ingles, Marcia, Crowfoot, Gary, Smelaya, Tamara V., Kuzovlev, Artem N., Salnikova, Lubov E., Bhikoo, Raisa, Khwannimit, Bodin, Bhurayanontachai, Rungsun, Vattanavanit, Veerapong, Tourteau, Emilie, Filali, Amel, van Grunderbeeck, Nicolas, Nigeon, Olivier, Bazus, Hélène, Masse, Juliette, Mallat, Jihad, Thevenin, Didier, Prokhorenko, Isabella, Kabanov, Dmitry, Zubova, Svetlana, Grachev, Sergey, Salcedo, Margarita, Witte, Stephan, Cuvier, Valérie, Derive, Marc, Gibot, Sébastien, Garaud, Jean Jacques, Kumar, Vijay, Chhibber, Sanjay, Santos, Jerico R., Sevillejal, Jesus Emmanuel A D, Nevado, Jose B., Linge, Helena M., Ochani, Kanta, Lin, Ke, Lee, Ji Young, Wang, Ping, Tembhre, Manoj, Liu, Shu Fang, Singhal, Pravin C., Miller, Edmund J., HO, Jeffery, Liu, Xiaodong, Kwong, Thomas, Zhang, Lin, Chan, Hung, Wong, Sunny H., Choi, Gordon, Gin, Tony, Chan, Matthew T V, Wu, William K K, Vliegen, Gwendolyn, Kehoe, Kaat, Verkerk, Robert, Fransen, Erik, Peters, Esther, Lambeir, Anne Marie, Pickkers, Peter, Jorens, Philippe G., De Meester, Ingrid, Ribeiro, Aline Barbosa, Souza, Ana Paula Trevelin, Giusti, Humberto, Franci, Celso Rodrigues, Saia, Rafael Simone, Anderko, Renee R., Jackson, Vanessa M., Palmer, Octavia M Peck, Angus, Derek C., Kellum, John A., Carcillo, Joseph A., Verboom, D. M., Koster-Brouwer, M. E., van de Groep, K., Frencken, J. F., Scicluna, B., Gisbertz, S. S., Henegouwen, M. I van Berge, Ruurda, J. P., van Hillegersberg, R., van der Poll, T., Bonten, M. J M, Cremer, O. L., Klouwenberg, P. M C Klein, Beloborodova, Natalia, Osipov, Artem, Pautova, Alisa, Bedova, Aleksandra, Mas-Oliva, Jaime, García-González, Victor, Sukhina, Marina, Zhukhovitskiy, Vladimir, Sukhina, Marina A., Obraztsov, Igor, Zhukhovitskiy, Vladimir G., Peronace, Cinzia, Matera, Giovanni, Galati, Luisa, Giancotti, Aida, Barreca, Giorgio Settimo, Quirino, Angela, Liberto, Maria Carla, Focà, Alfredo, Labiad, Yasmine, Venton, Geoffroy, Baier, Céline, Colle, Julien, Farnault, Laure, Brunet, Corinne, Loriod, Béatrice, Fernandez-Nunez, Nicloas, Suchon, Pierre, Mattei, Jean Camille, Rihet, Pascal, Nguyen, Catherine, Costello, Régis, Tesfai, Abel, Ahmetaj-Shala, Blerina, Gashaw, Hime, Quinlan, Gregory, MacCallum, Niall, Mumby, Sharon, Gray, DNicola N., Leiper, James, Kirkby, Nicholas, Mitchell, Jane A., Costa, Luis Henrique A, Catalão, Carlos Henrique R, Santos-Júnior, Nilton N., Souza, Anderson O., Alberici, Luciane C., and Rocha, Maria José A

Published
2016

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