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3,073 results on '"Napolitano A"'

1. Early management of adult traumatic spinal cord injury in patients with polytrauma: a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)

Author: Picetti, E, Demetriades, A, Catena, F, Aarabi, B, Abu-Zidan, F, Alves, O, Ansaloni, L, Armonda, R, Badenes, R, Bala, M, Balogh, Z, Barbanera, A, Bertuccio, A, Biffl, W, Bouzat, P, Buki, A, Castano-Leon, A, Cerasti, D, Citerio, G, Coccolini, F, Coimbra, R, Coniglio, C, Costa, F, De Iure, F, Depreitere, B, Fainardi, E, Fehlings, M, Gabrovsky, N, Godoy, D, Gruen, P, Gupta, D, Hawryluk, G, Helbok, R, Hossain, I, Hutchinson, P, Iaccarino, C, Inaba, K, Ivanov, M, Kaprovoy, S, Kirkpatrick, A, Klein, S, Kolias, A, Konovalov, N, Lagares, A, Lippa, L, Loza-Gomez, A, Luoto, T, Maas, A, Maciejczak, A, Maier, R, Marklund, N, Martin, M, Melloni, I, Mendoza-Lattes, S, Meyfroidt, G, Munari, M, Napolitano, L, Okonkwo, D, Otomo, Y, Papadopoulos, M, Petr, O, Peul, W, Pudkrong, A, Qasim, Z, Rasulo, F, Reizinho, C, Ringel, F, Rizoli, S, Rostami, E, Rubiano, A, Russo, E, Sarwal, A, Schwab, J, Servadei, F, Sharma, D, Sharif, S, Shiban, E, Shutter, L, Stahel, P, Taccone, F, Terpolilli, N, Thomé, C, Toth, P, Tsitsopoulos, P, Udy, A, Vaccaro, A, Varon, A, Vavilala, M, Younsi, A, Zackova, M, Zoerle, T, Robba, C, Picetti, Edoardo, Demetriades, Andreas K., Catena, Fausto, Aarabi, Bizhan, Abu-Zidan, Fikri M., Alves, Oscar L., Ansaloni, Luca, Armonda, Rocco A., Badenes, Rafael, Bala, Miklosh, Balogh, Zsolt J., Barbanera, Andrea, Bertuccio, Alessandro, Biffl, Walter L., Bouzat, Pierre, Buki, Andras, Castano-Leon, Ana Maria, Cerasti, Davide, Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Costa, Francesco, De Iure, Federico, Depreitere, Bart, Fainardi, Enrico, Fehlings, Michael J., Gabrovsky, Nikolay, Godoy, Daniel Agustin, Gruen, Peter, Gupta, Deepak, Hawryluk, Gregory W. J., Helbok, Raimund, Hossain, Iftakher, Hutchinson, Peter J., Iaccarino, Corrado, Inaba, Kenji, Ivanov, Marcel, Kaprovoy, Stanislav, Kirkpatrick, Andrew W., Klein, Sam, Kolias, Angelos, Konovalov, Nikolay A., Lagares, Alfonso, Lippa, Laura, Loza-Gomez, Angelica, Luoto, Teemu M., Maas, Andrew I. R., Maciejczak, Andrzej, Maier, Ronald V., Marklund, Niklas, Martin, Matthew J., Melloni, Ilaria, Mendoza-Lattes, Sergio, Meyfroidt, Geert, Munari, Marina, Napolitano, Lena M., Okonkwo, David O., Otomo, Yasuhiro, Papadopoulos, Marios C., Petr, Ondra, Peul, Wilco C., Pudkrong, Aichholz K., Qasim, Zaffer, Rasulo, Frank, Reizinho, Carla, Ringel, Florian, Rizoli, Sandro, Rostami, Elham, Rubiano, Andres M., Russo, Emanuele, Sarwal, Aarti, Schwab, Jan M., Servadei, Franco, Sharma, Deepak, Sharif, Salman, Shiban, Ehab, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Terpolilli, Nicole A., Thomé, Claudius, Toth, Peter, Tsitsopoulos, Parmenion P., Udy, Andrew, Vaccaro, Alexander R., Varon, Albert J., Vavilala, Monica S., Younsi, Alexander, Zackova, Monika, Zoerle, Tommaso, Robba, Chiara, Picetti, E, Demetriades, A, Catena, F, Aarabi, B, Abu-Zidan, F, Alves, O, Ansaloni, L, Armonda, R, Badenes, R, Bala, M, Balogh, Z, Barbanera, A, Bertuccio, A, Biffl, W, Bouzat, P, Buki, A, Castano-Leon, A, Cerasti, D, Citerio, G, Coccolini, F, Coimbra, R, Coniglio, C, Costa, F, De Iure, F, Depreitere, B, Fainardi, E, Fehlings, M, Gabrovsky, N, Godoy, D, Gruen, P, Gupta, D, Hawryluk, G, Helbok, R, Hossain, I, Hutchinson, P, Iaccarino, C, Inaba, K, Ivanov, M, Kaprovoy, S, Kirkpatrick, A, Klein, S, Kolias, A, Konovalov, N, Lagares, A, Lippa, L, Loza-Gomez, A, Luoto, T, Maas, A, Maciejczak, A, Maier, R, Marklund, N, Martin, M, Melloni, I, Mendoza-Lattes, S, Meyfroidt, G, Munari, M, Napolitano, L, Okonkwo, D, Otomo, Y, Papadopoulos, M, Petr, O, Peul, W, Pudkrong, A, Qasim, Z, Rasulo, F, Reizinho, C, Ringel, F, Rizoli, S, Rostami, E, Rubiano, A, Russo, E, Sarwal, A, Schwab, J, Servadei, F, Sharma, D, Sharif, S, Shiban, E, Shutter, L, Stahel, P, Taccone, F, Terpolilli, N, Thomé, C, Toth, P, Tsitsopoulos, P, Udy, A, Vaccaro, A, Varon, A, Vavilala, M, Younsi, A, Zackova, M, Zoerle, T, Robba, C, Picetti, Edoardo, Demetriades, Andreas K., Catena, Fausto, Aarabi, Bizhan, Abu-Zidan, Fikri M., Alves, Oscar L., Ansaloni, Luca, Armonda, Rocco A., Badenes, Rafael, Bala, Miklosh, Balogh, Zsolt J., Barbanera, Andrea, Bertuccio, Alessandro, Biffl, Walter L., Bouzat, Pierre, Buki, Andras, Castano-Leon, Ana Maria, Cerasti, Davide, Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Costa, Francesco, De Iure, Federico, Depreitere, Bart, Fainardi, Enrico, Fehlings, Michael J., Gabrovsky, Nikolay, Godoy, Daniel Agustin, Gruen, Peter, Gupta, Deepak, Hawryluk, Gregory W. J., Helbok, Raimund, Hossain, Iftakher, Hutchinson, Peter J., Iaccarino, Corrado, Inaba, Kenji, Ivanov, Marcel, Kaprovoy, Stanislav, Kirkpatrick, Andrew W., Klein, Sam, Kolias, Angelos, Konovalov, Nikolay A., Lagares, Alfonso, Lippa, Laura, Loza-Gomez, Angelica, Luoto, Teemu M., Maas, Andrew I. R., Maciejczak, Andrzej, Maier, Ronald V., Marklund, Niklas, Martin, Matthew J., Melloni, Ilaria, Mendoza-Lattes, Sergio, Meyfroidt, Geert, Munari, Marina, Napolitano, Lena M., Okonkwo, David O., Otomo, Yasuhiro, Papadopoulos, Marios C., Petr, Ondra, Peul, Wilco C., Pudkrong, Aichholz K., Qasim, Zaffer, Rasulo, Frank, Reizinho, Carla, Ringel, Florian, Rizoli, Sandro, Rostami, Elham, Rubiano, Andres M., Russo, Emanuele, Sarwal, Aarti, Schwab, Jan M., Servadei, Franco, Sharma, Deepak, Sharif, Salman, Shiban, Ehab, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Terpolilli, Nicole A., Thomé, Claudius, Toth, Peter, Tsitsopoulos, Parmenion P., Udy, Andrew, Vaccaro, Alexander R., Varon, Albert J., Vavilala, Monica S., Younsi, Alexander, Zackova, Monika, Zoerle, Tommaso, and Robba, Chiara
Abstract: Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician’s decision making in the management of tSCI polytrauma patients.
Published: 2024

2. Intradermal Tuberculin Test in Water Buffalo (Bubalus bubalis): Experimental use of Mycobacterial Antigens for the Diagnosis of Bovine Tuberculosis

Author: Martucciello, Alessandra, Mazzone, Piera, Napolitano, Francesco, Bezos, Javier, Grandoni, Francesco, Boniotti, Maria Beatrice, Cagiola, Monica, Cappelli, Giovanna, Di Vuolo, Gabriele, Galiero, Giorgio, Signorelli, Federica, De Carlo, Esterina, Martucciello, Alessandra, Mazzone, Piera, Napolitano, Francesco, Bezos, Javier, Grandoni, Francesco, Boniotti, Maria Beatrice, Cagiola, Monica, Cappelli, Giovanna, Di Vuolo, Gabriele, Galiero, Giorgio, Signorelli, Federica, and De Carlo, Esterina
Abstract: The study aims to evaluate the potential use of mycobacterial ESAT6 and CFP10 antigens, Early Secretory Proteins (ESP) in the Skin Test used for bovine tuberculosis (TB) diagnosis in Water Buffalo. A pilot study was performed on 21 buffaloes from a TB outbreak and 11 buffaloes from a TB-free herd. Three concentrations of ESAT6-CFP10 (10, 20, and 30 mg) and two of ESP (50 and 100 µg) were inoculated in the Skin Test, along with PPDB, PPDA, and PBS as a negative control. Skin thickness was measured with calipers before the test and every 24 hours for 4 days. Then, to evaluate the specificity of the antigens, a field study was conducted, and 100 buffaloes from a TB-free herd were inoculated using the best antigens concentration derived from the pilot study. In the positive buffaloes, the strongest skin response was to PPDB at 24h, with some subjects becoming inconclusive at 72 and 96 h. A peak response to PPDA at 48 hours was detected, followed by a slight decrease. The response to ESP-100 µg remained high at 24 and 48 h, then decreased, remaining positive at 72 h. In the 100 TB-free buffaloes, the best specificity was observed using ESAT6-CFP10 and ESP. ESP yielded the best results, showing higher reactivity in infected animals and no reactivity in the healthy ones at 72 h. Therefore, ESP could be an excellent candidate for further extensive studies in the buffalo species to improve Skin Test performance.
Published: 2024

3. First measurement of the yield of $^8$He isotopes produced in liquid scintillator by cosmic-ray muons at Daya Bay

Author: Daya Bay Collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., Zou, J. H., Daya Bay Collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Abstract: Daya Bay presents the first measurement of cosmogenic $^8$He isotope production in liquid scintillator, using an innovative method for identifying cascade decays of $^8$He and its child isotope, $^8$Li. We also measure the production yield of $^9$Li isotopes using well-established methodology. The results, in units of 10$^{-8}\mu^{-1}$g$^{-1}$cm$^{2}$, are 0.307$\pm$0.042, 0.341$\pm$0.040, and 0.546$\pm$0.076 for $^8$He, and 6.73$\pm$0.73, 6.75$\pm$0.70, and 13.74$\pm$0.82 for $^9$Li at average muon energies of 63.9~GeV, 64.7~GeV, and 143.0~GeV, respectively. The measured production rate of $^8$He isotopes is more than an order of magnitude lower than any other measurement of cosmogenic isotope production. It replaces the results of previous attempts to determine the ratio of $^8$He to $^9$Li production that yielded a wide range of limits from 0 to 30\%. The results provide future liquid-scintillator-based experiments with improved ability to predict cosmogenic backgrounds.
Published: 2024

4. Charged-current non-standard neutrino interactions at Daya Bay

Author: Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., Zou, J. H., Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Abstract: The full data set of the Daya Bay reactor neutrino experiment is used to probe the effect of the charged current non-standard interactions (CC-NSI) on neutrino oscillation experiments. Two different approaches are applied and constraints on the corresponding CC-NSI parameters are obtained with the neutrino flux taken from the Huber-Mueller model with a $5\%$ uncertainty. For the quantum mechanics-based approach (QM-NSI), the constraints on the CC-NSI parameters $\epsilon_{e\alpha}$ and $\epsilon_{e\alpha}^{s}$ are extracted with and without the assumption that the effects of the new physics are the same in the production and detection processes, respectively. The approach based on the weak effective field theory (WEFT-NSI) deals with four types of CC-NSI represented by the parameters $[\varepsilon_{X}]_{e\alpha}$. For both approaches, the results for the CC-NSI parameters are shown for cases with various fixed values of the CC-NSI and the Dirac CP-violating phases, and when they are allowed to vary freely. We find that constraints on the QM-NSI parameters $\epsilon_{e\alpha}$ and $\epsilon_{e\alpha}^{s}$ from the Daya Bay experiment alone can reach the order $\mathcal{O}(0.01)$ for the former and $\mathcal{O}(0.1)$ for the latter, while for WEFT-NSI parameters $[\varepsilon_{X}]_{e\alpha}$, we obtain $\mathcal{O}(0.1)$ for both cases., Comment: 25 pages, 16 figures, 6 tables; 36 pages, format changed, references added
Published: 2024

5. EUSO-SPB1 mission and science

Author: Abdellaoui, G., Abe, S., Adams, J.H., Allard, D., Alonso, G., Anchordoqui, L., Anzalone, A., Arnone, E., Asano, K., Atallah, R., Attoui, H., Ave Pernas, M., Bachmann, R., Bacholle, S., Bagheri, M., Bakiri, M., Baláz, J., Barghini, D., Bartocci, S., Battisti, M., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Belloti, R., Belov, A., Benmessai, K., Bertaina, M., Bertone, P. F., Biermann, P.L., Bisconti, F., Blaksley, C., Blanc, N., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bolmgren, K., Bozzo, E., Briz, S., Bruno, A., Caballero, K.S., Cafagna, F., Cambié, G., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Černý, K., Chikawa, M., Chiritoi, G., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H.J., Cremonini, R., Creusot, A., Cummings, A., Castro, A. de, Taille, C. de la, Peral, L. del, Desiato, J., Diaz Damian, A., Diesing, R., Dinaucourt, P., Djakonow, A., Djemil, T., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Filippatos, George, Finch, W., Fornaro, C., Fouka, M., Franceschi, A., Franchini Longhi, Sebastian Nicolas, Fuglesang, C., Fujii, T., Fukushima, M., Galeotti, P., García-Ortega, E., Gardiol, D., Garipov, G., Gascón, E., Gazda, E., Genci, J., Golzio, Alessio, Gorodetzky, P., Gregg, Robbie, Green, A., Guarino, F., Guépin, C., Guzmán, A., Hachisu, Y., Haungs, A., Heigbes, T., Hernández Carretero, J., Hulett, L., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Jochum, J., Joven, E., Judd, E.G., Jung, A., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kasztelan, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B.A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P.A., Kreykenbohm, I., Krizmanic, J.F., Królik, K., Kungel, V., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lahmar, H., Lakhdari, F., Licandro, J., López Campano, L., López Martínez, F., Mackovjak, S., Mahdi, M., Mandát, D., Manfrin, M, Marcelli, L., Marcos, J.L., Marszał, W., Martín, Y., Martínez, O., Mase, K., Mastafa, M., Matthews, J.N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Mese, M., Meseguer, J., Meyer, S.S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Ríos, J.A., Nachtman, J. M., Nagataki, S., Naitamor, S., Napolitano, T., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A.V., Onel, Y., Osteria, G., Otte, A. N., Pagliaro, A., Painter, W., Panasyuk, M.I., Panico, B., Parizot, E., Park, I.H., Pastircak, B., Paul, T., Pech, M., Pérez-Grande, Isabel, Perfetto, F., Peter, T., Picozza, P., Pindado Carrion, Santiago, Piotrowski, L.W., Piraino, S., Plebaniak, Z., Pollini, A., Popescu, E.M., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Puehlhofer, G., Putis, M., Reardon, P., Reno, M. H., Reyes, M., Ricci, M., Rodríguez Frías, M.D., Romero Matamala, O. F., Ronga, F., Sabau, M.D., Saccá, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez, J.L., Sanchez Balanzar, J.C., Santangelo, A., Sanz Andres, Angel Pedro, Saprykin, O., Sarazin, F., Sato, M., Scagliola, A., Schanz, T., Schieler, H., Schovánek, P., Scotti, V., Serra, M., Sharakin, S. A., Shimizu, H.M., Shinozaki, K., Soriano, J.F., Sotgiu, A., Stan, I., Strharský, I., Sugiyama, N., Supanitsky, D., Suzuki, M., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Talai, M.C., Tameda, Y., Tenzer, C., Thomas, S.B., Tibolla, O., Tkachev, L. G., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsunesada, Y., Tsuno, K., Turriziani, S., Uchihori, Y., Valdés-Galicia, J.F., Vallania, P., Valore, L., Vankova-Kirilova, G., Venters, T. M., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts Jr, J., Weigand Muñoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Yamamoto, T., Yang, J., Yano, H., Yashin, I.V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I.S., Zotov, M.Yu., Zuccaro Marchini, A., JEM-EUSO, Collaboration, Abdellaoui, G., Abe, S., Adams, J.H., Allard, D., Alonso, G., Anchordoqui, L., Anzalone, A., Arnone, E., Asano, K., Atallah, R., Attoui, H., Ave Pernas, M., Bachmann, R., Bacholle, S., Bagheri, M., Bakiri, M., Baláz, J., Barghini, D., Bartocci, S., Battisti, M., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Belloti, R., Belov, A., Benmessai, K., Bertaina, M., Bertone, P. F., Biermann, P.L., Bisconti, F., Blaksley, C., Blanc, N., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bolmgren, K., Bozzo, E., Briz, S., Bruno, A., Caballero, K.S., Cafagna, F., Cambié, G., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Černý, K., Chikawa, M., Chiritoi, G., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H.J., Cremonini, R., Creusot, A., Cummings, A., Castro, A. de, Taille, C. de la, Peral, L. del, Desiato, J., Diaz Damian, A., Diesing, R., Dinaucourt, P., Djakonow, A., Djemil, T., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Filippatos, George, Finch, W., Fornaro, C., Fouka, M., Franceschi, A., Franchini Longhi, Sebastian Nicolas, Fuglesang, C., Fujii, T., Fukushima, M., Galeotti, P., García-Ortega, E., Gardiol, D., Garipov, G., Gascón, E., Gazda, E., Genci, J., Golzio, Alessio, Gorodetzky, P., Gregg, Robbie, Green, A., Guarino, F., Guépin, C., Guzmán, A., Hachisu, Y., Haungs, A., Heigbes, T., Hernández Carretero, J., Hulett, L., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Jochum, J., Joven, E., Judd, E.G., Jung, A., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kasztelan, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B.A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P.A., Kreykenbohm, I., Krizmanic, J.F., Królik, K., Kungel, V., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lahmar, H., Lakhdari, F., Licandro, J., López Campano, L., López Martínez, F., Mackovjak, S., Mahdi, M., Mandát, D., Manfrin, M, Marcelli, L., Marcos, J.L., Marszał, W., Martín, Y., Martínez, O., Mase, K., Mastafa, M., Matthews, J.N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Mese, M., Meseguer, J., Meyer, S.S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Morales de los Ríos, J.A., Nachtman, J. M., Nagataki, S., Naitamor, S., Napolitano, T., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A.V., Onel, Y., Osteria, G., Otte, A. N., Pagliaro, A., Painter, W., Panasyuk, M.I., Panico, B., Parizot, E., Park, I.H., Pastircak, B., Paul, T., Pech, M., Pérez-Grande, Isabel, Perfetto, F., Peter, T., Picozza, P., Pindado Carrion, Santiago, Piotrowski, L.W., Piraino, S., Plebaniak, Z., Pollini, A., Popescu, E.M., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Puehlhofer, G., Putis, M., Reardon, P., Reno, M. H., Reyes, M., Ricci, M., Rodríguez Frías, M.D., Romero Matamala, O. F., Ronga, F., Sabau, M.D., Saccá, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sanchez, J.L., Sanchez Balanzar, J.C., Santangelo, A., Sanz Andres, Angel Pedro, Saprykin, O., Sarazin, F., Sato, M., Scagliola, A., Schanz, T., Schieler, H., Schovánek, P., Scotti, V., Serra, M., Sharakin, S. A., Shimizu, H.M., Shinozaki, K., Soriano, J.F., Sotgiu, A., Stan, I., Strharský, I., Sugiyama, N., Supanitsky, D., Suzuki, M., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Talai, M.C., Tameda, Y., Tenzer, C., Thomas, S.B., Tibolla, O., Tkachev, L. G., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsunesada, Y., Tsuno, K., Turriziani, S., Uchihori, Y., Valdés-Galicia, J.F., Vallania, P., Valore, L., Vankova-Kirilova, G., Venters, T. M., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts Jr, J., Weigand Muñoz, R., Weindl, A., Wiencke, L., Wille, M., Wilms, J., Yamamoto, T., Yang, J., Yano, H., Yashin, I.V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I.S., Zotov, M.Yu., Zuccaro Marchini, A., and JEM-EUSO, Collaboration
Abstract: The Extreme Universe Space Observatory on a Super Pressure Balloon 1 (EUSO-SPB1) was launched in 2017 April from Wanaka, New Zealand. The plan of this mission of opportunity on a NASA super pressure balloon test flight was to circle the southern hemisphere. The primary scientific goal was to make the first observations of ultra-high-energy cosmic-ray extensive air showers (EASs) by looking down on the atmosphere with an ultraviolet (UV) fluorescence telescope from suborbital altitude (33 km). After 12 days and 4 h aloft, the flight was terminated prematurely in the Pacific Ocean. Before the flight, the instrument was tested extensively in the West Desert of Utah, USA, with UV point sources and lasers. The test results indicated that the instrument had sensitivity to EASs of EeV. Simulations of the telescope system, telescope on time, and realized flight trajectory predicted an observation of about 1 event assuming clear sky conditions. The effects of high clouds were estimated to reduce this value by approximately a factor of 2. A manual search and a machine-learning-based search did not find any EAS signals in these data. Here we review the EUSO-SPB1 instrument and flight and the EAS search.
Published: 2024

6. Intradermal Tuberculin Test in Water Buffalo (Bubalus bubalis): Experimental use of Mycobacterial Antigens for the Diagnosis of Bovine Tuberculosis

Author: Martucciello, Alessandra, Mazzone, Piera, Napolitano, Francesco, Bezos Garrido, Javier, Grandoni, Francesco, Boniotti, Maria Beatrice, Cagiola, Monica, Cappelli, Giovanna, Di Vuolo, Gabriele, Galiero, Giorgio, Signorelli, Federica, De Carlo, Esterina, Martucciello, Alessandra, Mazzone, Piera, Napolitano, Francesco, Bezos Garrido, Javier, Grandoni, Francesco, Boniotti, Maria Beatrice, Cagiola, Monica, Cappelli, Giovanna, Di Vuolo, Gabriele, Galiero, Giorgio, Signorelli, Federica, and De Carlo, Esterina
Abstract: The study aims to evaluate the potential use of mycobacterial ESAT6 and CFP10 antigens, Early Secretory Proteins (ESP) in the Skin Test used for bovine tuberculosis (TB) diagnosis in Water Buffalo. A pilot study was performed on 21 buffaloes from a TB outbreak and 11 buffaloes from a TB-free herd. Three concentrations of ESAT6-CFP10 (10, 20, and 30 mg) and two of ESP (50 and 100 µg) were inoculated in the Skin Test, along with PPDB, PPDA, and PBS as a negative control. Skin thickness was measured with calipers before the test and every 24 hours for 4 days. Then, to evaluate the specificity of the antigens, a field study was conducted, and 100 buffaloes from a TB-free herd were inoculated using the best antigens concentration derived from the pilot study. In the positive buffaloes, the strongest skin response was to PPDB at 24h, with some subjects becoming inconclusive at 72 and 96 h. A peak response to PPDA at 48 hours was detected, followed by a slight decrease. The response to ESP-100 µg remained high at 24 and 48 h, then decreased, remaining positive at 72 h. In the 100 TB-free buffaloes, the best specificity was observed using ESAT6-CFP10 and ESP. ESP yielded the best results, showing higher reactivity in infected animals and no reactivity in the healthy ones at 72 h. Therefore, ESP could be an excellent candidate for further extensive studies in the buffalo species to improve Skin Test performance., Ministry of Health (Italia), European Commission, Depto. de Sanidad Animal, Fac. de Veterinaria, TRUE, pub
Published: 2024

7. Performance Assessment of Bachelor of Library and Information Science (BLIS) Students in their On-The-Job Training (OJT) for the Academic Year 2021-2022: Vol.3, No.1B

Author: Abainza, Lovely Mae B., Decelo, Angelie Anne B., Hunat, Sheryl R., Napolitano, Marife, Turno, Kevin A., Abainza, Lovely Mae B., Decelo, Angelie Anne B., Hunat, Sheryl R., Napolitano, Marife, and Turno, Kevin A.
Abstract: In order to implement the On-the-Job program for the Bachelor of Library and Information Science at Bestlink College of the Philippines, the study sought to identify the difficulties encountered by student trainees and practicum coordinators. The study involved the formulation of guiding questions and the selection of 30 fourth-year BLIS students through purposive sampling. Library Science programs often require students to complete internships, which can provide valuable real-world experience. Developing an internship program could benefit both the library and the student. A survey questionaire sent via Google Mail was used to collect data. Percentages and weighted mean were used to analyze the data that had been gathered. Student interns can help teachers and students by choosing books and other resources, promoting more reading, and enhancing vocabulary, general knowledge, and important concepts. Internships in libraries give students the chance to gain practical experience while also learning from seasoned librarians. The emphasis of these internships should be on education and learning. Regular updates to the Library and Information Science (LIS) curriculum are necessary to meet the evolving needs of LIS practitioners. There is often a gap between theory and practice in LIS, and inadequate resources such as computer laboratories and libraries limit students' hands-on experience. On-the-job training (OJT) is necessary to prepare students for the workforce and provide orientation, benefits, and motivation. This study evaluated the role of OJT in improving the knowledge of BLIS students at Bestlink College of the Philippines.
Published: 2024

8. Vertical Interaction Between NBC Rings and Its Implications for South Atlantic Water Export

Author: Napolitano, Dante C., Carton, Xavier, Gula, Jonathan, Napolitano, Dante C., Carton, Xavier, and Gula, Jonathan
Abstract: Northwestward‐propagating North Brazil Current (NBC) Rings are often destroyed upon reaching the Caribbean islands, carrying South Atlantic waters into the North Atlantic gyre and connecting the two branches of the Atlantic Meridional Overturning Circulation. Recent observations of NBC rings reported surface and subsurface cores separated by strong stratification. As independent structures, the subsurface eddies often appeared below—even if not aligned with—the surface rings. Motivated by these findings, this paper investigates the occurrence and consequences of vertical coupling between surface and subsurface NBC rings by applying a simplified theoretical model to a realistic numerical simulation. Eddy tracking in this complex simulation reveals around 1,600 instantaneous observations where eddies overlap. At each observation, we assess the eddies' vertical interaction with a 21/2‐layer quasi‐geostrophic framework. This interaction boils down to either coupling between the layers or a vertical splitting of the system, depending on eddy strength versus background shear. The effects of coupling include long‐lived eddies that can travel longer distances. These effects are particularly important for the lower layer, where differences between coupled and non‐coupled eddies are striking: about 40% of eddies with coupling travel 500 km, with ∼10% carrying South Atlantic Water up to the Caribbean sea. Without coupling, eddies propagate less than 150 km. During coupling, lower‐layer eddies could be driven by their surface counterparts to move offshore and bypass a topographic choke point, thus leaving the NBC retroflection region. Although still speculative, this idea explains the link between coupling and the increase in both lifetime and distance traveled for these eddies.
Published: 2024
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9. Production of Alternate Realizations of DESI Fiber Assignment for Unbiased Clustering Measurement in Data and Simulations

Author: Lasker, J., Rosell, A. Carnero, Myers, A. D., Ross, A. J., Bianchi, D., Hanif, M. M. S, Kehoe, R., de Mattia, A., Napolitano, L., Percival, W. J., Staten, R., Aguilar, J., Ahlen, S., Bigwood, L., Brooks, D., Claybaugh, T., Cole, S., de la Macorra, A., Ding, Z., Doel, P., Fanning, K., Forero-Romero, J. E., Gaztañaga, E., Gontcho, S. Gontcho A, Gutierrez, G., Honscheid, K., Howlett, C., Juneau, S., Kremin, A., Landriau, M., Guillou, L. Le, Levi, M. E., Manera, M., Meisner, A., Miquel, R., Moustakas, J., Mueller, E., Nie, J., Niz, G., Oh, M., Palanque-Delabrouille, N., Poppett, C., Prada, F., Rezaie, M., Rossi, G., Sanchez, E., Schlegel, D., Schubnell, M., Seo, H., Sprayberry, D., Tarlé, G., Vargas-Magaña, M., Weaver, B. A., Wilson, Michael J., Zheng, Y., Lasker, J., Rosell, A. Carnero, Myers, A. D., Ross, A. J., Bianchi, D., Hanif, M. M. S, Kehoe, R., de Mattia, A., Napolitano, L., Percival, W. J., Staten, R., Aguilar, J., Ahlen, S., Bigwood, L., Brooks, D., Claybaugh, T., Cole, S., de la Macorra, A., Ding, Z., Doel, P., Fanning, K., Forero-Romero, J. E., Gaztañaga, E., Gontcho, S. Gontcho A, Gutierrez, G., Honscheid, K., Howlett, C., Juneau, S., Kremin, A., Landriau, M., Guillou, L. Le, Levi, M. E., Manera, M., Meisner, A., Miquel, R., Moustakas, J., Mueller, E., Nie, J., Niz, G., Oh, M., Palanque-Delabrouille, N., Poppett, C., Prada, F., Rezaie, M., Rossi, G., Sanchez, E., Schlegel, D., Schubnell, M., Seo, H., Sprayberry, D., Tarlé, G., Vargas-Magaña, M., Weaver, B. A., Wilson, Michael J., and Zheng, Y.
Abstract: A critical requirement of spectroscopic large scale structure analyses is correcting for selection of which galaxies to observe from an isotropic target list. This selection is often limited by the hardware used to perform the survey which will impose angular constraints of simultaneously observable targets, requiring multiple passes to observe all of them. In SDSS this manifested solely as the collision of physical fibers and plugs placed in plates. In DESI, there is the additional constraint of the robotic positioner which controls each fiber being limited to a finite patrol radius. A number of approximate methods have previously been proposed to correct the galaxy clustering statistics for these effects, but these generally fail on small scales. To accurately correct the clustering we need to upweight pairs of galaxies based on the inverse probability that those pairs would be observed (Bianchi \& Percival 2017). This paper details an implementation of that method to correct the Dark Energy Spectroscopic Instrument (DESI) survey for incompleteness. To calculate the required probabilities, we need a set of alternate realizations of DESI where we vary the relative priority of otherwise identical targets. These realizations take the form of alternate Merged Target Ledgers (AMTL), the files that link DESI observations and targets. We present the method used to generate these alternate realizations and how they are tracked forward in time using the real observational record and hardware status, propagating the survey as though the alternate orderings had been adopted. We detail the first applications of this method to the DESI One-Percent Survey (SV3) and the DESI year 1 data. We include evaluations of the pipeline outputs, estimation of survey completeness from this and other methods, and validation of the method using mock galaxy catalogs., Comment: 30 pages, 21 figures
Published: 2024

10. Physical properties of strong 1 < z < 3 Balmer and Paschen lines emitters observed with JWST

Author: Seillé, L. -M., Buat, V., Fernández, V., Boquien, M., Roehlly, Y., Boselli, A., Calabrò, A., Amorín, R. O., Backhaus, B. E., Burgarella, D., Cleri, N. J., Dickinson, M., Hathi, N. P., Holwerda, B. W., Koekemoer, A. M., Napolitano, L., Pacucci, F., Robertson, C., Yung, L. Y. A., Seillé, L. -M., Buat, V., Fernández, V., Boquien, M., Roehlly, Y., Boselli, A., Calabrò, A., Amorín, R. O., Backhaus, B. E., Burgarella, D., Cleri, N. J., Dickinson, M., Hathi, N. P., Holwerda, B. W., Koekemoer, A. M., Napolitano, L., Pacucci, F., Robertson, C., and Yung, L. Y. A.
Abstract: The ultraviolet continuum traces young stars while the near-infrared unveils older stellar populations and dust-obscured regions. Balmer emission lines provide insights on gas properties and young stellar objects but are highly affected by dust attenuation. The near-infrared Paschen lines suffer less dust attenuation and can be used to measure star formation rates (SFRs) in star-forming regions obscured by dust clouds. We select 13 sources between redshifts 1 and 3 observed with HST, JWST/NIRCam and NIRSpec based on the availability of at least one Balmer and one Paschen line with S/N > 5. With a newly-developed version of CIGALE, we fit their hydrogen line equivalent widths (EWs) and photometric data. We assess the impacts of the removal of spectroscopic data by comparing the quality of the fits of the spectro-photometric data to those with photometric data only. We compare the single (BC03) vs binary (BPASS) stellar populations models in the fitting process of spectro-photometric data. We derive the differential attenuation and explore different attenuation recipes by fitting spectro-photometric data with BC03. For each stellar model and for each input dataset (with and without EWs), we quantify the deviation on the SFRs and stellar masses from the "standard" choice. On average, the SFRs are overestimated and the stellar masses are underestimated when EWs are not included as input data. We find a major contribution of the H${\alpha}$ emission line to the broadband photometric measurements of our sources, and a trend of increasing contribution with specific SFR. Using the BPASS models has a significant impact on the derived SFRs and stellar masses. We show that a flexible attenuation recipe provides more accurate estimates of the dust attenuation parameters, especially the differential attenuation which agrees with the original value of Charlot & Fall (2000)., Comment: Submitted to Astronomy & Astrophysics, 19 pages, 15 figures
Published: 2024

11. DESI 2024 IV: Baryon Acoustic Oscillations from the Lyman Alpha Forest

Author: DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Bautista, J., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Cruz, R., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, J., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçayli, N. G., Kehoe, R., Kent, S., Kirkby, D., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Linder, E., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Sinigaglia, F., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., Zou, H., DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Bautista, J., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Cruz, R., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, J., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçayli, N. G., Kehoe, R., Kent, S., Kirkby, D., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Linder, E., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M. M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Ravoux, C., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Sinigaglia, F., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., and Zou, H.
Abstract: We present the measurement of Baryon Acoustic Oscillations (BAO) from the Lyman-$\alpha$ (Ly$\alpha$) forest of high-redshift quasars with the first-year dataset of the Dark Energy Spectroscopic Instrument (DESI). Our analysis uses over $420\,000$ Ly$\alpha$ forest spectra and their correlation with the spatial distribution of more than $700\,000$ quasars. An essential facet of this work is the development of a new analysis methodology on a blinded dataset. We conducted rigorous tests using synthetic data to ensure the reliability of our methodology and findings before unblinding. Additionally, we conducted multiple data splits to assess the consistency of the results and scrutinized various analysis approaches to confirm their robustness. For a given value of the sound horizon ($r_d$), we measure the expansion at $z_{\rm eff}=2.33$ with 2\% precision, $H(z_{\rm eff}) = (239.2 \pm 4.8) (147.09~{\rm Mpc} /r_d)$ km/s/Mpc. Similarly, we present a 2.4\% measurement of the transverse comoving distance to the same redshift, $D_M(z_{\rm eff}) = (5.84 \pm 0.14) (r_d/147.09~{\rm Mpc})$ Gpc. Together with other DESI BAO measurements at lower redshifts, these results are used in a companion paper to constrain cosmological parameters., Comment: This DESI Collaboration Key Publication is part of the 2024 publication series using the first year of observations (see https://data.desi.lbl.gov/doc/papers)
Published: 2024

12. DESI 2024 VI: Cosmological Constraints from the Measurements of Baryon Acoustic Oscillations

Author: DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bahr-Kalus, B., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Bera, A., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Frenk, C. S., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Linder, E., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Shafieloo, A., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Taylor, P., Trusov, S., Ureña-López, L. A., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., Zhuang, T., Zou, H., DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bahr-Kalus, B., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Bera, A., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Frenk, C. S., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Linder, E., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Shafieloo, A., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Tan, T., Tarlé, G., Taylor, P., Trusov, S., Ureña-López, L. A., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., Zhuang, T., and Zou, H.
Abstract: We present cosmological results from the measurement of baryon acoustic oscillations (BAO) in galaxy, quasar and Lyman-$\alpha$ forest tracers from the first year of observations from the Dark Energy Spectroscopic Instrument (DESI), to be released in the DESI Data Release 1. DESI BAO provide robust measurements of the transverse comoving distance and Hubble rate, or their combination, relative to the sound horizon, in seven redshift bins from over 6 million extragalactic objects in the redshift range $0.1-1$ and $w_a<0$. This preference is 2.6$\sigma$ for the DESI+CMB combination, and persists or grows when SN~Ia are added in, giving results discrepant with the $\Lambda$CDM model at the $2.5\sigma$, $3.5\sigma$ or $3.9\sigma$ levels for the addition of Pantheon+, Union3, or DES-SN5YR datasets respectively. For the flat $\Lambda$CDM model with the sum of neutrino mass $\sum m_\nu$ free, combining the DESI and CMB data yields an upper limit $\sum m_\nu < 0.072$ $(0.113)$ eV at 95% confidence for a $\sum m_\nu>0$ $(\sum m_\nu>0.059)$ eV prior. These neutrino-mass constraints are substantially relaxed in models beyond $\Lambda$CDM. [Abridged.], Comment: This DESI Collaboration Key Publication is part of the 2024 publication series using the first year of observations (see https://data.desi.lbl.gov/doc/papers)
Published: 2024

13. DESI 2024 III: Baryon Acoustic Oscillations from Galaxies and Quasars

Author: DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Linder, E., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Swanson, J., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., Zou, H., DESI Collaboration, Adame, A. G., Aguilar, J., Ahlen, S., Alam, S., Alexander, D. M., Alvarez, M., Alves, O., Anand, A., Andrade, U., Armengaud, E., Avila, S., Aviles, A., Awan, H., Bailey, S., Baltay, C., Bault, A., Behera, J., BenZvi, S., Beutler, F., Bianchi, D., Blake, C., Blum, R., Brieden, S., Brodzeller, A., Brooks, D., Buckley-Geer, E., Burtin, E., Calderon, R., Canning, R., Rosell, A. Carnero, Cereskaite, R., Cervantes-Cota, J. L., Chabanier, S., Chaussidon, E., Chaves-Montero, J., Chen, S., Chen, X., Claybaugh, T., Cole, S., Cuceu, A., Davis, T. M., Dawson, K., de la Macorra, A., de Mattia, A., Deiosso, N., Dey, A., Dey, B., Ding, Z., Doel, P., Edelstein, J., Eftekharzadeh, S., Eisenstein, D. J., Elliott, A., Fagrelius, P., Fanning, K., Ferraro, S., Ereza, J., Findlay, N., Flaugher, B., Font-Ribera, A., Forero-Sánchez, D., Forero-Romero, J. E., Garcia-Quintero, C., Gaztañaga, E., Gil-Marín, H., Gontcho, S. Gontcho A, Gonzalez-Morales, A. X., Gonzalez-Perez, V., Gordon, C., Green, D., Gruen, D., Gsponer, R., Gutierrez, G., Guy, J., Hadzhiyska, B., Hahn, C., Hanif, M. M. S, Herrera-Alcantar, H. K., Honscheid, K., Howlett, C., Huterer, D., Iršič, V., Ishak, M., Juneau, S., Karaçaylı, N. G., Kehoe, R., Kent, S., Kirkby, D., Kremin, A., Krolewski, A., Lai, Y., Lan, T. -W., Landriau, M., Lang, D., Lasker, J., Goff, J. M. Le, Guillou, L. Le, Leauthaud, A., Levi, M. E., Li, T. S., Linder, E., Lodha, K., Magneville, C., Manera, M., Margala, D., Martini, P., Maus, M., McDonald, P., Medina-Varela, L., Meisner, A., Mena-Fernández, J., Miquel, R., Moon, J., Moore, S., Moustakas, J., Mudur, N., Mueller, E., Muñoz-Gutiérrez, A., Myers, A. D., Nadathur, S., Napolitano, L., Neveux, R., Newman, J. A., Nguyen, N. M., Nie, J., Niz, G., Noriega, H. E., Padmanabhan, N., Paillas, E., Palanque-Delabrouille, N., Pan, J., Penmetsa, S., Percival, W. J., Pieri, M., Pinon, M., Poppett, C., Porredon, A., Prada, F., Pérez-Fernández, A., Pérez-Ràfols, I., Rabinowitz, D., Raichoor, A., Ramírez-Pérez, C., Ramirez-Solano, S., Rashkovetskyi, M., Rezaie, M., Rich, J., Rocher, A., Rockosi, C., Roe, N. A., Rosado-Marin, A., Ross, A. J., Rossi, G., Ruggeri, R., Ruhlmann-Kleider, V., Samushia, L., Sanchez, E., Saulder, C., Schlafly, E. F., Schlegel, D., Schubnell, M., Seo, H., Sharples, R., Silber, J., Slosar, A., Smith, A., Sprayberry, D., Swanson, J., Tan, T., Tarlé, G., Trusov, S., Vaisakh, R., Valcin, D., Valdes, F., Vargas-Magaña, M., Verde, L., Walther, M., Wang, B., Wang, M. S., Weaver, B. A., Weaverdyck, N., Wechsler, R. H., Weinberg, D. H., White, M., Yu, J., Yu, Y., Yuan, S., Yèche, C., Zaborowski, E. A., Zarrouk, P., Zhang, H., Zhao, C., Zhao, R., Zhou, R., and Zou, H.
Abstract: We present the DESI 2024 galaxy and quasar baryon acoustic oscillations (BAO) measurements using over 5.7 million unique galaxy and quasar redshifts in the range 0.1
Published: 2024

14. The Rise of Faint, Red AGN at $z>4$: A Sample of Little Red Dots in the JWST Extragalactic Legacy Fields

Author: Kocevski, Dale D., Finkelstein, Steven L., Barro, Guillermo, Taylor, Anthony J., Calabrò, Antonello, Laloux, Brivael, Buchner, Johannes, Trump, Jonathan R., Leung, Gene C. K., Yang, Guang, Dickinson, Mark, Pérez-González, Pablo G., Pacucci, Fabio, Inayoshi, Kohei, Somerville, Rachel S., McGrath, Elizabeth J., Akins, Hollis B., Haro, Pablo Arrabal, Bagley, Micaela B., Bowler, Rebecca A. A., Carnall, Adam, Casey, Caitlin M., Cheng, Yingjie, Cleri, Nikko J., Costantin, Luca, Cullen, Fergus, Davis, Kelcey, Donnan, Callum T., Dunlop, James S., Ellis, Richard S., Ferguson, Henry C., Fujimoto, Seiji, Fontana, Adriano, Giavalisco, Mauro, Grazian, Andrea, Grogin, Norman A., Hathi, Nimish P., Hirschmann, Michaela, Huertas-Company, Marc, Holwerda, Benne W., Illingworth, Garth, Juneau, Stéphanie, Kartaltepe, Jeyhan S., Koekemoer, Anton M., Li, Wenxiu, Lucas, Ray A., Magee, Dan, Mason, Charlotte, McLeod, Derek J., McLure, Ross J., Napolitano, Lorenzo, Papovich, Casey, Pirzkal, Nor, Rodighiero, Giulia, Santini, Paola, Wilkins, Stephen M., Yung, L. Y. Aaron, Kocevski, Dale D., Finkelstein, Steven L., Barro, Guillermo, Taylor, Anthony J., Calabrò, Antonello, Laloux, Brivael, Buchner, Johannes, Trump, Jonathan R., Leung, Gene C. K., Yang, Guang, Dickinson, Mark, Pérez-González, Pablo G., Pacucci, Fabio, Inayoshi, Kohei, Somerville, Rachel S., McGrath, Elizabeth J., Akins, Hollis B., Haro, Pablo Arrabal, Bagley, Micaela B., Bowler, Rebecca A. A., Carnall, Adam, Casey, Caitlin M., Cheng, Yingjie, Cleri, Nikko J., Costantin, Luca, Cullen, Fergus, Davis, Kelcey, Donnan, Callum T., Dunlop, James S., Ellis, Richard S., Ferguson, Henry C., Fujimoto, Seiji, Fontana, Adriano, Giavalisco, Mauro, Grazian, Andrea, Grogin, Norman A., Hathi, Nimish P., Hirschmann, Michaela, Huertas-Company, Marc, Holwerda, Benne W., Illingworth, Garth, Juneau, Stéphanie, Kartaltepe, Jeyhan S., Koekemoer, Anton M., Li, Wenxiu, Lucas, Ray A., Magee, Dan, Mason, Charlotte, McLeod, Derek J., McLure, Ross J., Napolitano, Lorenzo, Papovich, Casey, Pirzkal, Nor, Rodighiero, Giulia, Santini, Paola, Wilkins, Stephen M., and Yung, L. Y. Aaron
Abstract: We present a sample of 341 "little red dots" (LRDs) spanning the redshift range $z\sim2-11$ using data from the CEERS, PRIMER, JADES, UNCOVER and NGDEEP surveys. These sources are likely heavily-reddened AGN that trace a previously-hidden phase of dust-obscured black hole growth in the early Universe. Unlike past use of color indices to identify LRDs, we employ continuum slope fitting using shifting bandpasses to sample the same rest-frame emission blueward and redward of the Balmer break. This approach allows us to identify LRDs over a wider redshift range and is less susceptible to contamination from galaxies with strong breaks that otherwise lack a rising red continuum. The redshift distribution of our sample increases at $z<8$ and then undergoes a rapid decline at $z\sim4.5$, which may tie the emergence, and obscuration, of these sources to the inside-out growth that galaxies experience during this epoch. We find that LRDs are 2-3 dex more numerous than bright quasars at $z\sim5-7$, but their number density is only 0.6-1 dex higher than X-ray and UV selected AGN at these redshifts. Within our sample, we have identified the first X-ray detected LRDs at $z=3.1$ and $z=4.66$. An X-ray spectral analysis confirms that these AGN are moderately obscured with $\log\,(N_{\rm H}/{\rm cm}^{2}$) of $23.3^{+0.4}_{-1.3}$ and $22.72^{+0.13}_{-0.16}$. Our analysis reveals that reddened AGN emission dominates their rest-optical light, while the rest-UV originates from their host galaxies. We also present NIRSpec follow-up spectroscopy of 17 LRDs that show broad emission lines consistent with AGN activity. The confirmed AGN fraction of our sample is $71\%$ for sources with F444W$<26.5$. In addition, we find three LRDs with narrow blue-shifted Balmer absorption features in their spectra, suggesting an outflow of high-density, low ionization gas from near the central engine of these faint, red AGN., Comment: 23 pages, 17 figures, submitted to ApJ
Published: 2024

15. JWST NIRSpec Spectroscopy of the Remarkable Bright Galaxy GHZ2/GLASS-z12 at Redshift 12.34

Author: Castellano, Marco, Napolitano, Lorenzo, Fontana, Adriano, Roberts-Borsani, Guido, Treu, Tommaso, Vanzella, Eros, Zavala, Jorge A., Haro, Pablo Arrabal, Calabrò, Antonello, Llerena, Mario, Mascia, Sara, Merlin, Emiliano, Paris, Diego, Pentericci, Laura, Santini, Paola, Bakx, Tom J. L. C., Bergamini, Pietro, Cupani, Guido, Dickinson, Mark, Filippenko, Alexei V., Glazebrook, Karl, Grillo, Claudio, Kelly, Patrick L., Malkan, Matthew A., Mason, Charlotte A., Morishita, Takahiro, Nanayakkara, Themiya, Rosati, Piero, Sani, Eleonora, Wang, Xin, Yoon, Ilsang, Castellano, Marco, Napolitano, Lorenzo, Fontana, Adriano, Roberts-Borsani, Guido, Treu, Tommaso, Vanzella, Eros, Zavala, Jorge A., Haro, Pablo Arrabal, Calabrò, Antonello, Llerena, Mario, Mascia, Sara, Merlin, Emiliano, Paris, Diego, Pentericci, Laura, Santini, Paola, Bakx, Tom J. L. C., Bergamini, Pietro, Cupani, Guido, Dickinson, Mark, Filippenko, Alexei V., Glazebrook, Karl, Grillo, Claudio, Kelly, Patrick L., Malkan, Matthew A., Mason, Charlotte A., Morishita, Takahiro, Nanayakkara, Themiya, Rosati, Piero, Sani, Eleonora, Wang, Xin, and Yoon, Ilsang
Abstract: We spectroscopically confirm the $M_{\rm UV} = -20.5$ mag galaxy GHZ2/GLASS-z12 to be at redshift $z=12.34$. The source was selected via NIRCam photometry in GLASS-JWST Early Release Science data, providing the first evidence of a surprising abundance of bright galaxies at $z \gtrsim 10$. The NIRSpec PRISM spectrum is remarkable and unlike any local analog. It shows significant detections of N IV, C IV, He II, O III, C III, O II, and Ne III lines, and the first detection in a high-redshift object of the O III Bowen fluorescence line at 3133 {\AA} rest-frame. The prominent C IV line with rest-frame equivalent width (EW) $\sim 46$ {\AA} puts GHZ2 in the category of extreme C IV emitters characterised by hard radiation fields. GHZ2 displays UV lines with EWs that are only found in active galactic nuclei (AGNs) or composite objects at low/intermediate redshifts, and UV line-intensity ratios that are compatible both with AGNs and star formation in a low-metallicity environment. The nondetection of the very high-ionization lines [Ne IV] and [Ne V], and the remarkable similarity between GHZ2 and other known C IV emitters, favors a scenario in which the high ionizing output is due to very low metallicity, massive stars forming in a dense environment. We estimate a metallicity $\lesssim 0.1 Z/{\rm Z}_{\odot}$, a high ionization parameter logU $>$ -2, a N/O abundance 4--5 times the solar value, and a subsolar C/O ratio similar to the recently discovered class of nitrogen-enhanced objects at high redshift. Considering its abundance patterns and the high stellar mass density ($10^4$ M$_{\odot}$ pc$^{-2}$), GHZ2 is an ideal formation site for the progenitors of today's globular clusters. The remarkable brightness of GHZ2 makes it a "Rosetta stone" for understanding the physics of galaxy formation within just 360 Myr after the Big Bang., Comment: 20 pages, 7 figures, 2 tables; Submitted to The Astrophysical Journal
Published: 2024

16. Evidence of extreme ionization conditions and low metallicity in GHZ2/GLASS-z12 from a combined analysis of NIRSpec and MIRI observations

Author: Calabro, Antonello, Castellano, Marco, Zavala, Jorge A., Pentericci, Laura, Haro, Pablo Arrabal, Bakx, Tom J. L. C., Burgarella, Denis, Casey, Caitlin M., Dickinson, Mark, Finkelstein, Steven L., Fontana, Adriano, Llerena, Mario, Mascia, Sara, Merlin, Emiliano, Mitsuhashi, Ikki, Napolitano, Lorenzo, Paris, Diego, Perez-Gonzalez, Pablo G., Roberts-Borsani, Guido, Santini, Paola, Treu, Tommaso, Vanzella, Eros, Calabro, Antonello, Castellano, Marco, Zavala, Jorge A., Pentericci, Laura, Haro, Pablo Arrabal, Bakx, Tom J. L. C., Burgarella, Denis, Casey, Caitlin M., Dickinson, Mark, Finkelstein, Steven L., Fontana, Adriano, Llerena, Mario, Mascia, Sara, Merlin, Emiliano, Mitsuhashi, Ikki, Napolitano, Lorenzo, Paris, Diego, Perez-Gonzalez, Pablo G., Roberts-Borsani, Guido, Santini, Paola, Treu, Tommaso, and Vanzella, Eros
Abstract: GHZ2/GLASS-z12 has been recently observed by JWST with both NIRSpec and MIRI spectrographs, making it the most distant galaxy ($z_{spec}=12.34$) with complete spectroscopic coverage from rest-frame UV to optical. It is identified as a strong CIV$_{1549}$ emitter with many other detected emission lines (NIV], HeII, OIII], NIII], CIII], [OII], [NeIII], [OIII], and H$\alpha$), including a remarkable OIII$_{1333}$ Bowen fluorescence line. We analyze in this paper the joint NIRSpec+MIRI spectral data set. Combining six optical diagnostics (namely R2, R3, R23, O32, Ne3O2, and Ne3O2Hd), we find extreme ionization conditions, with O32 $=1.39 \pm 0.19$ and Ne3O2 $=0.37 \pm 0.18$ in stark excess compared to typical values in the ISM at lower redshifts. These line properties are compatible either with an AGN or with a compact, very dense star-forming environment ($\Sigma_{\rm SFR}$ $\sim 10^2$-$10^3$ Msun/yr/kpc$^2$), with a high ionization parameter ($\log_{10}$(U) $=-1.75 \pm 0.16$), a high ionizing photon production efficiency $\log(\xi_{\rm ion}) = 25.7_{-0.1}^{+0.2}$, and a low, although not pristine, metal content ranging between $5\%$ and $11\%$ Z$_\odot$, indicating a rapid enrichment of the ISM in the last few Myrs. These properties also suggest that a substantial amount of ionizing photons ($\sim 10\%$) are leaking outside. The general lessons learned from GHZ2 are the following: (i) the UV to optical combined nebular indicators are broadly in agreement with UV-only or optical-only indicators. (ii) UV+optical diagnostics fail to discriminate between an AGN and star-formation in a low metallicity, high density, and extreme ionization environment. (iii) comparing the nebular line ratios with local analogs may be approaching its limits at $z \gtrsim 10$, as this approach is potentially challenged by the unique conditions of star formation experienced by galaxies at these extreme redshifts., Comment: 14 pages, 3 figures, and 1 table. Submitted to ApJ
Published: 2024

17. Physical properties of extreme emission-line galaxies at $z\sim 4-9$ from the JWST CEERS survey

Author: Llerena, M., Amorín, R., Pentericci, L., Haro, P. Arrabal, Backhaus, B. E., Bagley, M. B., Calabrò, A., Cleri, N. J., Davis, K., Dickinson, M., Finkelstein, S. L., Gawiser, E., Grogin, N. A., Hathi, N. P., Hirschmann, M., Kartaltepe, J. S., Koekemoer, A. M., McGrath, E. J., Mobasher, B., Napolitano, L., Papovich, C., Pirzkal, N., Trump, J. R., Wilkins, S. M., Yung, L. Y. A., Llerena, M., Amorín, R., Pentericci, L., Haro, P. Arrabal, Backhaus, B. E., Bagley, M. B., Calabrò, A., Cleri, N. J., Davis, K., Dickinson, M., Finkelstein, S. L., Gawiser, E., Grogin, N. A., Hathi, N. P., Hirschmann, M., Kartaltepe, J. S., Koekemoer, A. M., McGrath, E. J., Mobasher, B., Napolitano, L., Papovich, C., Pirzkal, N., Trump, J. R., Wilkins, S. M., and Yung, L. Y. A.
Abstract: Extreme emission line galaxies (EELGs) are typically characterized by high equivalent widths (EWs) which are driven by elevated specific star formation rates (sSFR) in low-mass galaxies with subsolar metallicities and little dust. Such extreme systems are rare in the local universe, but the number density of EELGs increases with redshift. Such starburst galaxies are currently presumed to be the main drivers of hydrogen reionization over 5.50.4-1 which indicates that star formation may be the dominant source of ionization. Based on the photometric fluxes, we find an increase of EW([OIII]+H$\beta$) with sSFR and $\Sigma_{SFR}$, and a decrease with age and stellar mass. The sample of EELGs can reach $\Sigma_{SFR}>$10Msun yr$^{-1}$kpc$^{-2}$ which indicate they are strong candidates of LyC leakers. Another indirect indicator is the high values of O32>5 that can be reached for some galaxies in the sample., Comment: Submitted to A&A
Published: 2024

18. The evolution of the SFR and $\Sigma_{SFR}$ of galaxies in cosmic morning ($4<z<10$)

Author: Calabrò, A., Pentericci, L., Santini, P., Ferrara, A., Llerena, M., Mascia, S., Napolitano, L., Yung, L. Y. A., Bisigello, L., Cleri, N. J., Dekel, A., Dickinson, M., Franco, M., Giavalisco, M., Hirschmann, M., Holwerda, B. W., Koekemoer, A. M., Lucas, R. A., Pacucci, F., Pirzkal, N., Roberts-Borsani, G., Seillé, L. M., Tacchella, S., Wilkins, S., Amorín, R., Haro, P. Arrabal, Bagley, M. B., Finkelstein, S. L., Kartaltepe, J. S., Papovich, C., Calabrò, A., Pentericci, L., Santini, P., Ferrara, A., Llerena, M., Mascia, S., Napolitano, L., Yung, L. Y. A., Bisigello, L., Cleri, N. J., Dekel, A., Dickinson, M., Franco, M., Giavalisco, M., Hirschmann, M., Holwerda, B. W., Koekemoer, A. M., Lucas, R. A., Pacucci, F., Pirzkal, N., Roberts-Borsani, G., Seillé, L. M., Tacchella, S., Wilkins, S., Amorín, R., Haro, P. Arrabal, Bagley, M. B., Finkelstein, S. L., Kartaltepe, J. S., and Papovich, C.
Abstract: The galaxy integrated star-formation rate (SFR) surface density ($\Sigma_{\rm SFR}$) has been proposed as a valuable diagnostic of the mass accumulation in galaxies as being more tightly related to the physics of star-formation (SF) and stellar feedback than other SF indicators. In this paper, we assemble a statistical sample of 230 galaxies observed with JWST in the GLASS and CEERS spectroscopic surveys to estimate Balmer line based dust attenuations and SFRs, and UV rest-frame effective radii. We study the evolution of galaxy SFR and $\Sigma_{\rm SFR}$ in the first 1.5 Billion years of our Universe, finding that $\Sigma_{\rm SFR}$ is mildly increasing with redshift with a linear slope of $0.16 \pm 0.06$. We also explore the dependence of SFR and $\Sigma_{\rm SFR}$ on stellar mass, showing that a SF 'Main-Sequence' and a $\Sigma_{\rm SFR}$ `Main-Sequence' are in place out to z=10, with a similar slope compared to the same relations at lower redshifts. We find that the specific SFR (sSFR) and $\Sigma_{\rm SFR}$ are correlated with the [OIII]5007/[OII]3727 ratio and with indirect estimates of the escape fraction of Lyman continuum photons, hence they likely play an important role in the evolution of ionization conditions and in the escape of ionizing radiation. We also search for spectral outflow signatures in a subset of galaxies observed at high resolution, finding an outflow incidence of $2/11$ ($=20\%^{32\%}_{9\%}$) at $z<6$, but no evidence at $z>6$ ($<26\%$). Finally, we find a positive correlation between A$_V$ and $\Sigma_{\rm SFR}$, and a flat trend as a function of sSFR, indicating that there is no evidence of a drop of A$_V$ in extremely star-forming galaxies between z=4 and 10. This might be at odds with a dust-clearing outflow scenario, which might instead take place at redshifts $z\geq 10$, as suggested by some theoretical models., Comment: Submitted to A&A ; 17 pages, 9 figures, 1 table
Published: 2024

19. Peering into cosmic reionization: the Ly$\alpha$ visibility evolution from galaxies at $z$ = 4.5-8.5 with JWST

Author: Napolitano, L., Pentericci, L., Santini, P., Calabrò, A., Mascia, S., Llerena, M., Castellano, M., Dickinson, M., Finkelstein, S. L., Amorin, R., Haro, P. Arrabal, Bagley, M., Bhatawdekar, R., Cleri, N. J., Davis, K., Gardner, J. P., Gawiser, E., Giavalisco, M., Hathi, N., Hu, W., Jung, I., Kartaltepe, J. S., Koekemoer, A. M., Merlin, E., Mobasher, B., Papovich, C., Park, H., Pirzkal, N., Trump, J. R., Wilkins, S. M., Yung, L. Y. A., Napolitano, L., Pentericci, L., Santini, P., Calabrò, A., Mascia, S., Llerena, M., Castellano, M., Dickinson, M., Finkelstein, S. L., Amorin, R., Haro, P. Arrabal, Bagley, M., Bhatawdekar, R., Cleri, N. J., Davis, K., Gardner, J. P., Gawiser, E., Giavalisco, M., Hathi, N., Hu, W., Jung, I., Kartaltepe, J. S., Koekemoer, A. M., Merlin, E., Mobasher, B., Papovich, C., Park, H., Pirzkal, N., Trump, J. R., Wilkins, S. M., and Yung, L. Y. A.
Abstract: The resonant scattering interaction between Ly$\alpha$ photons and neutral hydrogen implies that a partially neutral IGM can significantly impact the detectability of Ly$\alpha$ emission in galaxies. The redshift evolution of the Ly$\alpha$ equivalent width distribution of galaxies thus offers a key probe of the degree of ionization during the Epoch of Reionization (EoR). Previous in-depth investigations at $z$ $\geq$ 7 were limited by ground-based instrument capabilities. We present an extensive study of Ly$\alpha$ emission from galaxies at 4 < $z$ < 8.5, observed from the CEERS and JADES surveys in the JWST NIRSpec/PRISM configuration. The sample consists of 235 galaxies, among which we identify 65 as Ly$\alpha$ emitters. We first measure Ly$\alpha$ escape fractions from Balmer lines, and explore the correlations with the inferred galaxies' physical properties, which are similar to those found at lower redshift. We also investigate the possible connection between the escape of Ly$\alpha$ photons and the inferred escape fractions of LyC photons obtained from indirect indicators. We then analyze the redshift evolution of the Ly$\alpha$ emitter fraction, finding lower average values at $z$ = 5 and 6 compared to ground-based observations. At $z$ = 7 we find a very large difference in Ly$\alpha$ visibility between the EGS and GOODS-South fields, possibly due to the presence of early reionized regions in the EGS. Such large variance is also expected in the Cosmic Dawn II radiation-hydrodynamical simulation. Our findings suggest a scenario in which the ending phase of the EoR is characterized by $\sim$ 1 pMpc ionized bubbles around a high fraction of moderately bright galaxies. Finally, we characterize such two ionized regions found in the EGS at $z$ = 7.18 and $z$ = 7.49 by estimating the radius of the ionized bubble that each of the spectroscopically-confirmed members could have created., Comment: Submitted to A&A
Published: 2024

20. Characterizing the Average Interstellar Medium Conditions of Galaxies at $z\sim$ 5.6-9 with UV and Optical Nebular Lines

Author: Hu, Weida, Papovich, Casey, Dickinson, Mark, Kennicutt, Robert, Shen, Lu, Amorín, Ricardo O., Haro, Pablo Arrabal, Bagley, Micaela B., Bhatawdekar, Rachana, Cleri, Nikko J., Cole, Justin W., Dekel, Avishai, de la Vega, Alexander, Finkelstein, Steven L., Grogin, Norman A., Hathi, Nimish P., Hirschmann, Michaela, Holwerda, Benne W., Hutchison, Taylor A., Jung, Intae, Koekemoer, Anton M., Kartaltepe, Jeyhan S., Lucas, Ray A., Llerena, Mario, Mascia, S., Mobasher, Bahram, Napolitano, L., Newman, Jeffrey A., Pentericci, Laura, Pérez-González, Pablo G., Trump, Jonathan R., Wilkins, Stephen M., Yung, L. Y. Aaron, Hu, Weida, Papovich, Casey, Dickinson, Mark, Kennicutt, Robert, Shen, Lu, Amorín, Ricardo O., Haro, Pablo Arrabal, Bagley, Micaela B., Bhatawdekar, Rachana, Cleri, Nikko J., Cole, Justin W., Dekel, Avishai, de la Vega, Alexander, Finkelstein, Steven L., Grogin, Norman A., Hathi, Nimish P., Hirschmann, Michaela, Holwerda, Benne W., Hutchison, Taylor A., Jung, Intae, Koekemoer, Anton M., Kartaltepe, Jeyhan S., Lucas, Ray A., Llerena, Mario, Mascia, S., Mobasher, Bahram, Napolitano, L., Newman, Jeffrey A., Pentericci, Laura, Pérez-González, Pablo G., Trump, Jonathan R., Wilkins, Stephen M., and Yung, L. Y. Aaron
Abstract: Ultraviolet (UV; rest-frame $\sim1200-2000$ A) spectra provide a wealth of diagnostics to characterize fundamental galaxy properties, such as their chemical enrichment, the nature of their stellar populations, and their amount of Lyman-continuum (LyC) radiation. In this work, we leverage publicly released JWST data to construct the rest-frame UV-to-optical composite spectrum of a sample of 63 galaxies at $5.6
Published: 2024

21. Citations or dollars? Early signals of a firm’s research success

Author: Xu, Shuqi; https://orcid.org/0000-0003-2072-6477, Mariani, Manuel Sebastian; https://orcid.org/0000-0003-1032-5821, Lu, Linyuan, Napolitano, Lorenzo; https://orcid.org/0000-0001-7829-7340, Pugliese, Emanuele, Zaccaria, Andrea, Xu, Shuqi; https://orcid.org/0000-0003-2072-6477, Mariani, Manuel Sebastian; https://orcid.org/0000-0003-1032-5821, Lu, Linyuan, Napolitano, Lorenzo; https://orcid.org/0000-0001-7829-7340, Pugliese, Emanuele, and Zaccaria, Andrea
Abstract: Scientific and technological progress is largely driven by firms in many domains, including artificial intelligence and vaccine development. The early identification of the future performance of innovation players is a relevant goal for policymakers and practitioners. In this work, we investigate how the future trajectory of a firm can be predicted by the economic or technological value of its early patents. By inspecting the patenting life cycles of 7440 publicly listed firms, we find that the economic value of a firm’s early patents is an accurate predictor of various dimensions of a firm’s future research success. At the same time, a smaller set of future top-performers do not generate early patents of high economic value, but they are detectable via the technological value of their early patents. Importantly, the observed heterogeneity of the firms’ temporal success patterns markedly differs from the patterns previously observed for individuals’ research careers.
Published: 2024

22. The slow Arrhenius process in small organic molecules

Author: Caporaletti, Federico, Napolitano, Simone, Caporaletti, Federico, and Napolitano, Simone
Abstract: info:eu-repo/semantics/published
Published: 2024

23. Tracing the slow Arrhenius process deep in the glassy state–quantitative evaluation of the dielectric relaxation of bulk samples and thin polymer films in the temperature domain

Author: Thoms, Erik, Li, Chun, Napolitano, Simone, Thoms, Erik, Li, Chun, and Napolitano, Simone
Abstract: info:eu-repo/semantics/published
Published: 2024

24. EUSO-SPB1 Mission and Science

Author: Collaboration, JEM-EUSO, Abdellaoui, G., Abe, S., Adams. Jr., J. H., Allard, D., Alonso, G., Anchordoqui, L., Anzalone, A., Arnone, E., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bachmann, R., Bacholle, S., Bagheri, M., Bakiri, M., Baláz, J., Barghini, D., Bartocci, S., Battisti, M., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A. A., Benmessai, K., Bertaina, M., Bertone, P. F., Biermann, P. L., Bisconti, F., Blaksley, C., Blanc, N., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bolmgren, K., Bozzo, E., Briz, S., Bruno, A., Caballero, K. S., Cafagna, F., Cambié, G., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Černý, K., Chikawa, M., Chiritoi, G., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Cummings, A., Gónzalez, A. de Castro, de la Taille, C., del Peral, L., Desiato, J., Damian, A. Diaz, Diesing, R., Dinaucourt, P., Djakonow, A., Djemil, T., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Filippatos, G., Finch, W., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fukushima, M., Galeotti, P., García-Ortega, E., Gardiol, D., Garipov, G. K., Gascón, E., Gazda, E., Genci, J., Golzio, A., Gorodetzky, P., Gregg, R., Green, A., Guarino, F., Guépin, C., Guzmán, A., Hachisu, Y., Haungs, A., Heigbes, T., Carretero, J. Hernández, Hulett, L., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Jochum, J., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kasztelan, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kreykenbohm, I., Krizmanic, J. F., Królik, K., Kungel, V., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lahmar, H., Lakhdari, F., Licandro, J., Campano, L. López, Martínez, F. López, Mackovjak, S., Mahdi, M., Mandát, D., Manfrin, M., Marcelli, L., Marcos, J. L., Marszał, W., Martín, Y., Martinez, O., Mase, K., Mastafa, M., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Mese, M., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Nachtman, J. M., Nagataki, S., Naitamor, S., Napolitano, T., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Onel, Y., Osteria, G., Otte, A. N., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Paul, T., Pech, M., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Plebaniak, Z., Pollini, A., Popescu, E. M., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Puehlhofer, G., Putis, M., Reardon, P., Reno, M. H., Reyes, M., Ricci, M., Frías, M. D. Rodríguez, Matamala, O. F. Romero, Ronga, F., Sabau, M. D., Saccá, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sánchez, J. L., Balanzar, J. C. Sanchez, Santangelo, A., Sanz-Andrés, A., Saprykin, O. A., Sarazin, F., Sato, M., Scagliola, A., Schanz, T., Schieler, H., Schovánek, P., Scotti, V., Serra, M., Sharakin, S. A., Shimizu, H. M., Shinozaki, K., Soriano, J. F., Sotgiu, A., Stan, I., Strharský, I., Sugiyama, N., Supanitsky, D., Suzuki, M., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L. G., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsunesada, Y., Tsuno, K., Turriziani, S., Uchihori, Y., Valdés-Galicia, J. F., Vallania, P., Valore, L., Vankova-Kirilova, G., Venters, T. M., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts. Jr., J., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., Marchi, A. Zuccaro, Collaboration, JEM-EUSO, Abdellaoui, G., Abe, S., Adams. Jr., J. H., Allard, D., Alonso, G., Anchordoqui, L., Anzalone, A., Arnone, E., Asano, K., Attallah, R., Attoui, H., Pernas, M. Ave, Bachmann, R., Bacholle, S., Bagheri, M., Bakiri, M., Baláz, J., Barghini, D., Bartocci, S., Battisti, M., Bayer, J., Beldjilali, B., Belenguer, T., Belkhalfa, N., Bellotti, R., Belov, A. A., Benmessai, K., Bertaina, M., Bertone, P. F., Biermann, P. L., Bisconti, F., Blaksley, C., Blanc, N., Blin-Bondil, S., Bobik, P., Bogomilov, M., Bolmgren, K., Bozzo, E., Briz, S., Bruno, A., Caballero, K. S., Cafagna, F., Cambié, G., Campana, D., Capdevielle, J. N., Capel, F., Caramete, A., Caramete, L., Caruso, R., Casolino, M., Cassardo, C., Castellina, A., Catalano, O., Cellino, A., Černý, K., Chikawa, M., Chiritoi, G., Christl, M. J., Colalillo, R., Conti, L., Cotto, G., Crawford, H. J., Cremonini, R., Creusot, A., Cummings, A., Gónzalez, A. de Castro, de la Taille, C., del Peral, L., Desiato, J., Damian, A. Diaz, Diesing, R., Dinaucourt, P., Djakonow, A., Djemil, T., Ebersoldt, A., Ebisuzaki, T., Eser, J., Fenu, F., Fernández-González, S., Ferrarese, S., Filippatos, G., Finch, W., Fornaro, C., Fouka, M., Franceschi, A., Franchini, S., Fuglesang, C., Fujii, T., Fukushima, M., Galeotti, P., García-Ortega, E., Gardiol, D., Garipov, G. K., Gascón, E., Gazda, E., Genci, J., Golzio, A., Gorodetzky, P., Gregg, R., Green, A., Guarino, F., Guépin, C., Guzmán, A., Hachisu, Y., Haungs, A., Heigbes, T., Carretero, J. Hernández, Hulett, L., Ikeda, D., Inoue, N., Inoue, S., Isgrò, F., Itow, Y., Jammer, T., Jeong, S., Jochum, J., Joven, E., Judd, E. G., Jung, A., Kajino, F., Kajino, T., Kalli, S., Kaneko, I., Kasztelan, M., Katahira, K., Kawai, K., Kawasaki, Y., Kedadra, A., Khales, H., Khrenov, B. A., Kim, Jeong-Sook, Kim, Soon-Wook, Kleifges, M., Klimov, P. A., Kreykenbohm, I., Krizmanic, J. F., Królik, K., Kungel, V., Kurihara, Y., Kusenko, A., Kuznetsov, E., Lahmar, H., Lakhdari, F., Licandro, J., Campano, L. López, Martínez, F. López, Mackovjak, S., Mahdi, M., Mandát, D., Manfrin, M., Marcelli, L., Marcos, J. L., Marszał, W., Martín, Y., Martinez, O., Mase, K., Mastafa, M., Matthews, J. N., Mebarki, N., Medina-Tanco, G., Menshikov, A., Merino, A., Mese, M., Meseguer, J., Meyer, S. S., Mimouni, J., Miyamoto, H., Mizumoto, Y., Monaco, A., Ríos, J. A. Morales de los, Nachtman, J. M., Nagataki, S., Naitamor, S., Napolitano, T., Neronov, A., Nomoto, K., Nonaka, T., Ogawa, T., Ogio, S., Ohmori, H., Olinto, A. V., Onel, Y., Osteria, G., Otte, A. N., Pagliaro, A., Painter, W., Panasyuk, M. I., Panico, B., Parizot, E., Park, I. H., Pastircak, B., Paul, T., Pech, M., Pérez-Grande, I., Perfetto, F., Peter, T., Picozza, P., Pindado, S., Piotrowski, L. W., Piraino, S., Plebaniak, Z., Pollini, A., Popescu, E. M., Prevete, R., Prévôt, G., Prieto, H., Przybylak, M., Puehlhofer, G., Putis, M., Reardon, P., Reno, M. H., Reyes, M., Ricci, M., Frías, M. D. Rodríguez, Matamala, O. F. Romero, Ronga, F., Sabau, M. D., Saccá, G., Sagawa, H., Sahnoune, Z., Saito, A., Sakaki, N., Salazar, H., Sánchez, J. L., Balanzar, J. C. Sanchez, Santangelo, A., Sanz-Andrés, A., Saprykin, O. A., Sarazin, F., Sato, M., Scagliola, A., Schanz, T., Schieler, H., Schovánek, P., Scotti, V., Serra, M., Sharakin, S. A., Shimizu, H. M., Shinozaki, K., Soriano, J. F., Sotgiu, A., Stan, I., Strharský, I., Sugiyama, N., Supanitsky, D., Suzuki, M., Szabelski, J., Tajima, N., Tajima, T., Takahashi, Y., Takeda, M., Takizawa, Y., Talai, M. C., Tameda, Y., Tenzer, C., Thomas, S. B., Tibolla, O., Tkachev, L. G., Tomida, T., Tone, N., Toscano, S., Traïche, M., Tsunesada, Y., Tsuno, K., Turriziani, S., Uchihori, Y., Valdés-Galicia, J. F., Vallania, P., Valore, L., Vankova-Kirilova, G., Venters, T. M., Vigorito, C., Villaseñor, L., Vlcek, B., von Ballmoos, P., Vrabel, M., Wada, S., Watanabe, J., Watts. Jr., J., Muñoz, R. Weigand, Weindl, A., Wiencke, L., Wille, M., Wilms, J., Yamamoto, T., Yang, J., Yano, H., Yashin, I. V., Yonetoku, D., Yoshida, S., Young, R., Zgura, I. S., Zotov, M. Yu., and Marchi, A. Zuccaro
Abstract: The Extreme Universe Space Observatory on a Super Pressure Balloon 1 (EUSO-SPB1) was launched in 2017 April from Wanaka, New Zealand. The plan of this mission of opportunity on a NASA super pressure balloon test flight was to circle the southern hemisphere. The primary scientific goal was to make the first observations of ultra-high-energy cosmic-ray extensive air showers (EASs) by looking down on the atmosphere with an ultraviolet (UV) fluorescence telescope from suborbital altitude (33~km). After 12~days and 4~hours aloft, the flight was terminated prematurely in the Pacific Ocean. Before the flight, the instrument was tested extensively in the West Desert of Utah, USA, with UV point sources and lasers. The test results indicated that the instrument had sensitivity to EASs of approximately 3 EeV. Simulations of the telescope system, telescope on time, and realized flight trajectory predicted an observation of about 1 event assuming clear sky conditions. The effects of high clouds were estimated to reduce this value by approximately a factor of 2. A manual search and a machine-learning-based search did not find any EAS signals in these data. Here we review the EUSO-SPB1 instrument and flight and the EAS search., Comment: 18 pages, 19 figures
Published: 2024
Full Text: View/download PDF

25. The new Italian SIDAPA Baseline Series for patch testing (2023): an update according to the new regulatory pathway for contact allergens

Author: Luca, S, Leonardo, B, S, C, Fortina Anna, B, Francesca, C, Monica, C, Alessandro, B, Rosella, G, Ilaria, T, M, F, Andrea, B, Fabrizio, G, Emanuela, M, Maddalena, N, Lucia Mario, D, Cataldo, P, Luigi, B, Paolo, R, Caterina, F, Marta, T, Rossella, M, Giuseppe, A, Katharina, H, Abategiovanni, L, Albertazzi, D, Ali Biglu Marash, S, Amendolagine, G, Angelini, G, Annunziata, A, Assalve, D, Ayala, F, Babino, G, Barruscotti, S, Battista, T, Berta, M, Biondi, F, Boccaletti, V, Bonamonte, D, Bruni, F, Buffon, R, Caccavale, S, Calabrese, L, Calzavara Pinton, P, Camela, E, Carugno, A, Casciola, G, Cecchini, E, Cristaudo, A, D'Agostino, M, Damiani, G, Danese, P, Dattola, A, DE Salvo, V, Errichetti, E, Esposito, G, Esposito, M, Fantini, C, Fontana, E, Fornaro, L, Adina Frasin, L, Galeotti, T, Gasparini, G, Genco, L, Gravante, M, Guastaferro, D, Guerrasio, G, Guerriero, L, Lauro, W, Lucagnano, G, Malatesta, N, Desmond Mandel, V, Marano, L, Marino, V, Martora, F, Menna, L, Miano, C, Miccio, L, Michelerio, A, Milanesi, N, Monfrecola, G, Motolese, A, Nocerino, M, Noto, M, Ornielli, M, Pacifico, A, Papini, M, Pasolini, G, Penchini, L, Perazzolli, G, Peserico, A, Piccolo, V, Pigatto, P, Potestio, L, Pugliese, A, Recalcati, S, Rivetti, N, Rossi, M, Russo, F, Russo, T, Schena, D, Sensini, C, Tesauri, D, Marco Tomassini, G, Ventura, V, Venturini, M, Vezzoli, P, Vincenzi, C, Stingeni Luca, Bianchi Leonardo, Caroppo Elena S, Belloni Fortina Anna, Caroppo Francesca, Corazza Monica, Borghi Alessandro, Gallo Rosella, Trave Ilaria, Ferrucci Silvia M, Beretta Andrea, Guarneri Fabrizio, Martina Emanuela, Napolitano Maddalena, De Lucia Mario, Patruno Cataldo, Bennardo Luigi, Romita Paolo, Foti Caterina, Tramontana Marta, Marietti Rossella, Argenziano Giuseppe, Hansel Katharina, Luisa Abategiovanni, Donatella Albertazzi, Samane Ali Biglu Marash, Graziana Amendolagine, Gianni Angelini, Alberto Annunziata, Danilo Assalve, Fabio Ayala, Graziella Babino, Stefania Barruscotti, Teresa Battista, Mauro Berta, Filippo Biondi, Valeria Boccaletti, Domenico Bonamonte, Francesca Bruni, Rosana Buffon, Stefano Caccavale, Laura Calabrese, Piergiacomo Calzavara Pinton, Elisa Camela, Andrea Carugno, Gabriele Casciola, Elisa Cecchini, Antonio Cristaudo, Michela D'Agostino, Giovanni Damiani, Pietro Danese, Annunziata Dattola, Vincenzo DE Salvo, Enzo Errichetti, Gianluca Esposito, Maria Esposito, Carolina Fantini, Elena Fontana, Luigi Fornaro, Lucretia Adina Frasin, Tommaso Galeotti, Giulia Gasparini, Lucia Genco, Massimo Gravante, Donatella Guastaferro, Gianluca Guerrasio, Luigi Guerriero, Wanda Lauro, Gioacchino Lucagnano, Nicolò Malatesta, Victor Desmond Mandel, Laura Marano, Vincenzo Marino, Fabrizio Martora, Luca Menna, Chiara Miano, Laura Miccio, Andrea Michelerio, Nicola Milanesi, Giuseppe Monfrecola, Alberico Motolese, Mariateresa Nocerino, Matteo Noto, Matteo Ornielli, Alessia Pacifico, Manuela Papini, Giorgio Pasolini, Luca Penchini, Gabriele Perazzolli, Andrea Peserico, Vincenzo Piccolo, Paolo Pigatto, Luca Potestio, Antonio Pugliese, Sebastiano Recalcati, Nicolò Rivetti, Mariateresa Rossi, Filomena Russo, Teresa Russo, Donatella Schena, Chiara Sensini, David Tesauri, Gian Marco Tomassini, Virginia Ventura, Marina Venturini, Pamela Vezzoli, Colombina Vincenzi, Luca, S, Leonardo, B, S, C, Fortina Anna, B, Francesca, C, Monica, C, Alessandro, B, Rosella, G, Ilaria, T, M, F, Andrea, B, Fabrizio, G, Emanuela, M, Maddalena, N, Lucia Mario, D, Cataldo, P, Luigi, B, Paolo, R, Caterina, F, Marta, T, Rossella, M, Giuseppe, A, Katharina, H, Abategiovanni, L, Albertazzi, D, Ali Biglu Marash, S, Amendolagine, G, Angelini, G, Annunziata, A, Assalve, D, Ayala, F, Babino, G, Barruscotti, S, Battista, T, Berta, M, Biondi, F, Boccaletti, V, Bonamonte, D, Bruni, F, Buffon, R, Caccavale, S, Calabrese, L, Calzavara Pinton, P, Camela, E, Carugno, A, Casciola, G, Cecchini, E, Cristaudo, A, D'Agostino, M, Damiani, G, Danese, P, Dattola, A, DE Salvo, V, Errichetti, E, Esposito, G, Esposito, M, Fantini, C, Fontana, E, Fornaro, L, Adina Frasin, L, Galeotti, T, Gasparini, G, Genco, L, Gravante, M, Guastaferro, D, Guerrasio, G, Guerriero, L, Lauro, W, Lucagnano, G, Malatesta, N, Desmond Mandel, V, Marano, L, Marino, V, Martora, F, Menna, L, Miano, C, Miccio, L, Michelerio, A, Milanesi, N, Monfrecola, G, Motolese, A, Nocerino, M, Noto, M, Ornielli, M, Pacifico, A, Papini, M, Pasolini, G, Penchini, L, Perazzolli, G, Peserico, A, Piccolo, V, Pigatto, P, Potestio, L, Pugliese, A, Recalcati, S, Rivetti, N, Rossi, M, Russo, F, Russo, T, Schena, D, Sensini, C, Tesauri, D, Marco Tomassini, G, Ventura, V, Venturini, M, Vezzoli, P, Vincenzi, C, Stingeni Luca, Bianchi Leonardo, Caroppo Elena S, Belloni Fortina Anna, Caroppo Francesca, Corazza Monica, Borghi Alessandro, Gallo Rosella, Trave Ilaria, Ferrucci Silvia M, Beretta Andrea, Guarneri Fabrizio, Martina Emanuela, Napolitano Maddalena, De Lucia Mario, Patruno Cataldo, Bennardo Luigi, Romita Paolo, Foti Caterina, Tramontana Marta, Marietti Rossella, Argenziano Giuseppe, Hansel Katharina, Luisa Abategiovanni, Donatella Albertazzi, Samane Ali Biglu Marash, Graziana Amendolagine, Gianni Angelini, Alberto Annunziata, Danilo Assalve, Fabio Ayala, Graziella Babino, Stefania Barruscotti, Teresa Battista, Mauro Berta, Filippo Biondi, Valeria Boccaletti, Domenico Bonamonte, Francesca Bruni, Rosana Buffon, Stefano Caccavale, Laura Calabrese, Piergiacomo Calzavara Pinton, Elisa Camela, Andrea Carugno, Gabriele Casciola, Elisa Cecchini, Antonio Cristaudo, Michela D'Agostino, Giovanni Damiani, Pietro Danese, Annunziata Dattola, Vincenzo DE Salvo, Enzo Errichetti, Gianluca Esposito, Maria Esposito, Carolina Fantini, Elena Fontana, Luigi Fornaro, Lucretia Adina Frasin, Tommaso Galeotti, Giulia Gasparini, Lucia Genco, Massimo Gravante, Donatella Guastaferro, Gianluca Guerrasio, Luigi Guerriero, Wanda Lauro, Gioacchino Lucagnano, Nicolò Malatesta, Victor Desmond Mandel, Laura Marano, Vincenzo Marino, Fabrizio Martora, Luca Menna, Chiara Miano, Laura Miccio, Andrea Michelerio, Nicola Milanesi, Giuseppe Monfrecola, Alberico Motolese, Mariateresa Nocerino, Matteo Noto, Matteo Ornielli, Alessia Pacifico, Manuela Papini, Giorgio Pasolini, Luca Penchini, Gabriele Perazzolli, Andrea Peserico, Vincenzo Piccolo, Paolo Pigatto, Luca Potestio, Antonio Pugliese, Sebastiano Recalcati, Nicolò Rivetti, Mariateresa Rossi, Filomena Russo, Teresa Russo, Donatella Schena, Chiara Sensini, David Tesauri, Gian Marco Tomassini, Virginia Ventura, Marina Venturini, Pamela Vezzoli, and Colombina Vincenzi
Abstract: Allergic contact dermatitis (ACD) is a common inflammatory skin disease caused by delayed hypersensitivity to chemical and biotic contact allergens. ACD significantly affects the patients' quality of life negatively impacting both occupational and non-occupational settings. Patch testing is the gold standard diagnostic in vivo test to precise the ACD etiology and to correctly perform prevention. According to the Italian Medicines Agency (AIFA) legislative decree no. 178 of 29th May 1991, allergens are defined as medicines and therefore they are subject to strict regulation. In 2017, AIFA (decree no. 2130/2017) started a procedure to regulate contact allergens on the Italian market and actually the contact allergens temporarily authorized are reported in AIFA decree no. 98/2022, valid until November 2023. The availability on the market of contact allergens to diagnose ACD and continuous updating on the basis of new epidemiological trends are mandatory, jointly with the continuous update of the baseline and integrative series for patch testing. For this reason, the scientific community represented in Italy by the Skin Allergies Study Group of SIDeMaST (Italian Society of Dermatology and Venereology) and SIDAPA (Italian Society of Allergological, Occupational and Environmental Dermatology) are constantly working, in close relationship with the European scientific communities with large expertise in this important sector of the modern Dermatology. Herein, we report the setting up of regulatory legislation by AIFA and the new Italian Adult Baseline Series for patch testing.
Published: 2024

26. Lifetime exposure to air pollution and academic achievement:A nationwide cohort study in Denmark

Author: Lim, Youn-Hee, Bilsteen, Josephine Funck, Mortensen, Laust Hvas, Lanzky, Linnea Ranja Mignon, Zhang, Jiawei, Tuffier, Stéphane, Brandt, Jørgen, Ketzel, Matthias, Flensborg-Madsen, Trine, Wimmelmann, Cathrine Lawaetz, Okholm, Gunhild Tidemann, Hegelund, Emilie Rune, Napolitano, George Maria, Andersen, Zorana Jovanovic, Loft, Steffen, Lim, Youn-Hee, Bilsteen, Josephine Funck, Mortensen, Laust Hvas, Lanzky, Linnea Ranja Mignon, Zhang, Jiawei, Tuffier, Stéphane, Brandt, Jørgen, Ketzel, Matthias, Flensborg-Madsen, Trine, Wimmelmann, Cathrine Lawaetz, Okholm, Gunhild Tidemann, Hegelund, Emilie Rune, Napolitano, George Maria, Andersen, Zorana Jovanovic, and Loft, Steffen
Abstract: Recent research suggests a link between air pollution and cognitive development in children, and studies on air pollution and academic achievement are emerging. We conducted a nationwide cohort study in Denmark to explore the associations between lifetime exposure to air pollution and academic performance in 9th grade. The study encompassed 785,312 children born in Denmark between 1989 and 2005, all of whom completed 9th-grade exit examinations. Using linear mixed models with a random intercept for each school, we assessed the relationship between 16 years of exposure to PM2.5, PM10, and gaseous pollutants and Grade Point Averages (GPA) in exit examinations, covering subjects such as Danish literature, Danish writing, English, mathematics, and natural sciences. The study revealed that a 5 µg/m3 increase in PM2.5 and PM10 was associated with a decrease of 0.99 (95 % Confidence Intervals: -1.05, -0.92) and 0.46 (-0.50, -0.41) in GPA, respectively. Notably, these negative associations were more pronounced in mathematics and natural sciences compared to language-related subjects. Additionally, girls and children with non-Danish mothers were found to be particularly susceptible to the adverse effects of air pollution exposure. These results underscore the potential long-term consequences of air pollution on academic achievement, emphasizing the significance of interventions that foster healthier environments for children's cognitive development.
Published: 2024

27. Correlation between allostatic load index and cumulative mortality:a register-based study of Danish municipalities

Author: Bruun-Rasmussen, Neda Esmailzadeh, Napolitano, George, Bojesen, Stig Egil, Ellervik, Christina, Holmager, Therese Lucia Friis, Lynge, Elsebeth, Bruun-Rasmussen, Neda Esmailzadeh, Napolitano, George, Bojesen, Stig Egil, Ellervik, Christina, Holmager, Therese Lucia Friis, and Lynge, Elsebeth
Abstract: Objectives The aim of this study was to examine population-based allostatic load (AL) indices as an indicator of community health across 14 municipalities in Denmark. Design Register-based study. Setting Data derived from: the Lolland-Falster Health Study, the Copenhagen General Population Study and the Danish General Suburban Population Study. Nine biomarkers (systolic blood pressure, diastolic blood pressure, pulse rate, total serum cholesterol, high-density lipoprotein cholesterol, waist-to-hip ratio, triglycerides, C-reactive protein and serum albumin) were divided into high-risk and low-risk values based on clinically accepted criteria, and the AL index was defined as the average between the nine values. All-cause mortality data were obtained from Statistics Denmark. Participants We examined a total of 106 808 individuals aged 40–79 years. Primary outcome measure Linear regression models were performed to investigate the association between mean AL index and cumulative mortality risk. Results Mean AL index was higher in men (range 2.3–3.3) than in women (range 1.7–2.6). We found AL index to be strongly correlated with the cumulative mortality rate, correlation coefficient of 0.82. A unit increase in mean AL index corresponded to an increase in the cumulative mortality rate of 19% (95% CI 13% to 25%) for men, and 16% (95% CI 8% to 23%) for women but this difference was not statistically significant. The overall mean increase in cumulative mortality rate for both men and women was 17% (95% CI 14% to 20%). Conclusions Our findings indicate the population-based AL index to be a strong indicator of community health, and suggest identification of targets for reducing AL.
Published: 2024

28. Self-Reported Health as Predictor of Allostatic Load and All-Cause Mortality:Findings From the Lolland-Falster Health Study

Author: Bruun-Rasmussen, Neda Esmailzadeh, Napolitano, George, Bojesen, Stig Egil, Ellervik, Christina, Rasmussen, Knud, Lynge, Elsebeth, Bruun-Rasmussen, Neda Esmailzadeh, Napolitano, George, Bojesen, Stig Egil, Ellervik, Christina, Rasmussen, Knud, and Lynge, Elsebeth
Abstract: Objectives: The aim was to determine the association between self-reported health (SRH), allostatic load (AL) and mortality. Methods: Data derived from the Lolland-Falster Health Study undertaken in Denmark from 2016–2020 (n = 14,104). Median follow-up time for death was 4.6 years where 456 participants died. SRH was assessed with a single question and AL by an index of ten biomarkers. Multinomial regression analysis were used to examine the association between SRH and AL, and Cox regression to explore the association between SRH, AL and mortality. Results: The risk of high AL increased by decreasing level of SRH. The ratio of relative risk (RRR) of having medium vs. low AL was 1.58 (1.11–2.23) in women reporting poor/very poor SRH as compared with very good SRH. For men it was 1.84 (1.20–2.81). For high vs. low AL, the RRR was 2.43 (1.66–3.56) in women and 2.96 (1.87–4.70) in men. The hazard ratio (HR) for all-cause mortality increased by decreasing SRH. For poor/very poor vs. very good SRH, the HR was 6.31 (2.84–13.99) in women and 3.92 (2.12–7.25) in men. Conclusion: Single-item SRH was able to predict risk of high AL and all-cause mortality.
Published: 2024

29. Lifetime exposure to air pollution and academic achievement:A nationwide cohort study in Denmark

Author: Lim, Youn-Hee, Bilsteen, Josephine Funck, Mortensen, Laust Hvas, Lanzky, Linnea Ranja Mignon, Zhang, Jiawei, Tuffier, Stéphane, Brandt, Jørgen, Ketzel, Matthias, Flensborg-Madsen, Trine, Wimmelmann, Cathrine Lawaetz, Okholm, Gunhild Tidemann, Hegelund, Emilie Rune, Napolitano, George Maria, Andersen, Zorana Jovanovic, Loft, Steffen, Lim, Youn-Hee, Bilsteen, Josephine Funck, Mortensen, Laust Hvas, Lanzky, Linnea Ranja Mignon, Zhang, Jiawei, Tuffier, Stéphane, Brandt, Jørgen, Ketzel, Matthias, Flensborg-Madsen, Trine, Wimmelmann, Cathrine Lawaetz, Okholm, Gunhild Tidemann, Hegelund, Emilie Rune, Napolitano, George Maria, Andersen, Zorana Jovanovic, and Loft, Steffen
Abstract: Recent research suggests a link between air pollution and cognitive development in children, and studies on air pollution and academic achievement are emerging. We conducted a nationwide cohort study in Denmark to explore the associations between lifetime exposure to air pollution and academic performance in 9th grade. The study encompassed 785,312 children born in Denmark between 1989 and 2005, all of whom completed 9th-grade exit examinations. Using linear mixed models with a random intercept for each school, we assessed the relationship between 16 years of exposure to PM2.5, PM10, and gaseous pollutants and Grade Point Averages (GPA) in exit examinations, covering subjects such as Danish literature, Danish writing, English, mathematics, and natural sciences. The study revealed that a 5 µg/m3 increase in PM2.5 and PM10 was associated with a decrease of 0.99 (95 % Confidence Intervals: -1.05, -0.92) and 0.46 (-0.50, -0.41) in GPA, respectively. Notably, these negative associations were more pronounced in mathematics and natural sciences compared to language-related subjects. Additionally, girls and children with non-Danish mothers were found to be particularly susceptible to the adverse effects of air pollution exposure. These results underscore the potential long-term consequences of air pollution on academic achievement, emphasizing the significance of interventions that foster healthier environments for children's cognitive development.
Published: 2024

30. Correlation between allostatic load index and cumulative mortality:a register-based study of Danish municipalities

Author: Bruun-Rasmussen, Neda Esmailzadeh, Napolitano, George, Bojesen, Stig Egil, Ellervik, Christina, Holmager, Therese Lucia Friis, Lynge, Elsebeth, Bruun-Rasmussen, Neda Esmailzadeh, Napolitano, George, Bojesen, Stig Egil, Ellervik, Christina, Holmager, Therese Lucia Friis, and Lynge, Elsebeth
Abstract: Objectives The aim of this study was to examine population-based allostatic load (AL) indices as an indicator of community health across 14 municipalities in Denmark. Design Register-based study. Setting Data derived from: the Lolland-Falster Health Study, the Copenhagen General Population Study and the Danish General Suburban Population Study. Nine biomarkers (systolic blood pressure, diastolic blood pressure, pulse rate, total serum cholesterol, high-density lipoprotein cholesterol, waist-to-hip ratio, triglycerides, C-reactive protein and serum albumin) were divided into high-risk and low-risk values based on clinically accepted criteria, and the AL index was defined as the average between the nine values. All-cause mortality data were obtained from Statistics Denmark. Participants We examined a total of 106 808 individuals aged 40–79 years. Primary outcome measure Linear regression models were performed to investigate the association between mean AL index and cumulative mortality risk. Results Mean AL index was higher in men (range 2.3–3.3) than in women (range 1.7–2.6). We found AL index to be strongly correlated with the cumulative mortality rate, correlation coefficient of 0.82. A unit increase in mean AL index corresponded to an increase in the cumulative mortality rate of 19% (95% CI 13% to 25%) for men, and 16% (95% CI 8% to 23%) for women but this difference was not statistically significant. The overall mean increase in cumulative mortality rate for both men and women was 17% (95% CI 14% to 20%). Conclusions Our findings indicate the population-based AL index to be a strong indicator of community health, and suggest identification of targets for reducing AL.
Published: 2024

31. Self-Reported Health as Predictor of Allostatic Load and All-Cause Mortality:Findings From the Lolland-Falster Health Study

Author: Bruun-Rasmussen, Neda Esmailzadeh, Napolitano, George, Bojesen, Stig Egil, Ellervik, Christina, Rasmussen, Knud, Lynge, Elsebeth, Bruun-Rasmussen, Neda Esmailzadeh, Napolitano, George, Bojesen, Stig Egil, Ellervik, Christina, Rasmussen, Knud, and Lynge, Elsebeth
Abstract: Objectives: The aim was to determine the association between self-reported health (SRH), allostatic load (AL) and mortality. Methods: Data derived from the Lolland-Falster Health Study undertaken in Denmark from 2016–2020 (n = 14,104). Median follow-up time for death was 4.6 years where 456 participants died. SRH was assessed with a single question and AL by an index of ten biomarkers. Multinomial regression analysis were used to examine the association between SRH and AL, and Cox regression to explore the association between SRH, AL and mortality. Results: The risk of high AL increased by decreasing level of SRH. The ratio of relative risk (RRR) of having medium vs. low AL was 1.58 (1.11–2.23) in women reporting poor/very poor SRH as compared with very good SRH. For men it was 1.84 (1.20–2.81). For high vs. low AL, the RRR was 2.43 (1.66–3.56) in women and 2.96 (1.87–4.70) in men. The hazard ratio (HR) for all-cause mortality increased by decreasing SRH. For poor/very poor vs. very good SRH, the HR was 6.31 (2.84–13.99) in women and 3.92 (2.12–7.25) in men. Conclusion: Single-item SRH was able to predict risk of high AL and all-cause mortality.
Published: 2024

32. Fast Processing Affects the Relaxation of Polymers: The Slow Arrhenius Process Can Probe Stress at the Molecular Level

Author: Thoms, Erik, Wang, Kai, Chandran, Sivasurender, Napolitano, Simone, Thoms, Erik, Wang, Kai, Chandran, Sivasurender, and Napolitano, Simone
Abstract: info:eu-repo/semantics/published
Published: 2024

33. Simple Model to Predict the Adsorption Rate of Polymer Melts

Author: Thoms, Erik, Song, Zijian, Wang, Kai, Napolitano, Simone, Thoms, Erik, Song, Zijian, Wang, Kai, and Napolitano, Simone
Abstract: info:eu-repo/semantics/published
Published: 2024

34. Measurement of Electron Antineutrino Oscillation Amplitude and Frequency via Neutron Capture on Hydrogen at Daya Bay

Author: Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. -C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., Zou, J. H., Daya Bay collaboration, An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. -C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Treskov, K., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Abstract: This Letter reports the first measurement of the oscillation amplitude and frequency of reactor antineutrinos at Daya Bay via neutron capture on hydrogen using 1958 days of data. With over 3.6 million signal candidates, an optimized candidate selection, improved treatment of backgrounds and efficiencies, refined energy calibration, and an energy response model for the capture-on-hydrogen sensitive region, the relative $\overline{\nu}_{e}$ rates and energy spectra variation among the near and far detectors gives $\mathrm{sin}^22\theta_{13} = 0.0759_{-0.0049}^{+0.0050}$ and $\Delta m^2_{32} = (2.72^{+0.14}_{-0.15})\times10^{-3}$ eV$^2$ assuming the normal neutrino mass ordering, and $\Delta m^2_{32} = (-2.83^{+0.15}_{-0.14})\times10^{-3}$ eV$^2$ for the inverted neutrino mass ordering. This estimate of $\sin^2 2\theta_{13}$ is consistent with and essentially independent from the one obtained using the capture-on-gadolinium sample at Daya Bay. The combination of these two results yields $\mathrm{sin}^22\theta_{13}= 0.0833\pm0.0022$, which represents an 8% relative improvement in precision regarding the Daya Bay full 3158-day capture-on-gadolinium result.
Published: 2024

35. Search for a sub-eV sterile neutrino using Daya Bay's full dataset

Author: An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., Zou, J. H., An, F. P., Bai, W. D., Balantekin, A. B., Bishai, M., Blyth, S., Cao, G. F., Cao, J., Chang, J. F., Chang, Y., Chen, H. S., Chen, H. Y., Chen, S. M., Chen, Y., Chen, Y. X., Chen, Z. Y., Cheng, J., Cheng, Y. C., Cheng, Z. K., Cherwinka, J. J., Chu, M. C., Cummings, J. P., Dalager, O., Deng, F. S., Ding, X. Y., Ding, Y. Y., Diwan, M. V., Dohnal, T., Dolzhikov, D., Dove, J., Dugas, K. V., Duyang, H. Y., Dwyer, D. A., Gallo, J. P., Gonchar, M., Gong, G. H., Gong, H., Gu, W. Q., Guo, J. Y., Guo, L., Guo, X. H., Guo, Y. H., Guo, Z., Hackenburg, R. W., Han, Y., Hans, S., He, M., Heeger, K. M., Heng, Y. K., Hor, Y. K., Hsiung, Y. B., Hu, B. Z., Hu, J. R., Hu, T., Hu, Z. J., Huang, H. X., Huang, J. H., Huang, X. T., Huang, Y. B., Huber, P., Jaffe, D. E., Jen, K. L., Ji, X. L., Ji, X. P., Johnson, R. A., Jones, D., Kang, L., Kettell, S. H., Kohn, S., Kramer, M., Langford, T. J., Lee, J., Lee, J. H. C., Lei, R. T., Leitner, R., Leung, J. K. C., Li, F., Li, H. L., Li, J. J., Li, Q. J., Li, R. H., Li, S., Li, S. C., Li, W. D., Li, X. N., Li, X. Q., Li, Y. F., Li, Z. B., Liang, H., Lin, C. J., Lin, G. L., Lin, S., Ling, J. J., Link, J. M., Littenberg, L., Littlejohn, B. R., Liu, J. C., Liu, J. L., Liu, J. X., Lu, C., Lu, H. Q., Luk, K. B., Ma, B. Z., Ma, X. B., Ma, X. Y., Ma, Y. Q., Mandujano, R. C., Marshall, C., McDonald, K. T., McKeown, R. D., Meng, Y., Napolitano, J., Naumov, D., Naumova, E., Nguyen, T. M. T., Ochoa-Ricoux, J. P., Olshevskiy, A., Park, J., Patton, S., Peng, J. C., Pun, C. S. J., Qi, F. Z., Qi, M., Qian, X., Raper, N., Ren, J., Reveco, C. Morales, Rosero, R., Roskovec, B., Ruan, X. C., Russell, B., Steiner, H., Sun, J. L., Tmej, T., Tse, W. -H., Tull, C. E., Tung, Y. C., Viren, B., Vorobel, V., Wang, C. H., Wang, J., Wang, M., Wang, N. Y., Wang, R. G., Wang, W., Wang, X., Wang, Y. F., Wang, Z., Wang, Z. M., Wei, H. Y., Wei, L. H., Wei, W., Wen, L. J., Whisnant, K., White, C. G., Wong, H. L. H., Worcester, E., Wu, D. R., Wu, Q., Wu, W. J., Xia, D. M., Xie, Z. Q., Xing, Z. Z., Xu, H. K., Xu, J. L., Xu, T., Xue, T., Yang, C. G., Yang, L., Yang, Y. Z., Yao, H. F., Ye, M., Yeh, M., Young, B. L., Yu, H. Z., Yu, Z. Y., Yue, B. B., Zavadskyi, V., Zeng, S., Zeng, Y., Zhan, L., Zhang, C., Zhang, F. Y., Zhang, H. H., Zhang, J. L., Zhang, J. W., Zhang, Q. M., Zhang, S. Q., Zhang, X. T., Zhang, Y. M., Zhang, Y. X., Zhang, Y. Y., Zhang, Z. J., Zhang, Z. P., Zhang, Z. Y., Zhao, J., Zhao, R. Z., Zhou, L., Zhuang, H. L., and Zou, J. H.
Abstract: This Letter presents results of a search for the mixing of a sub-eV sterile neutrino with three active neutrinos based on the full data sample of the Daya Bay Reactor Neutrino Experiment, collected during 3158 days of detector operation, which contains $5.55 \times 10^{6}$ reactor \anue candidates identified as inverse beta-decay interactions followed by neutron-capture on gadolinium. The analysis benefits from a doubling of the statistics of our previous result and from improvements of several important systematic uncertainties. No significant oscillation due to mixing of a sub-eV sterile neutrino with active neutrinos was found. Exclusion limits are set by both Feldman-Cousins and CLs methods. Light sterile neutrino mixing with $\sin^2 2\theta_{14} \gtrsim 0.01$ can be excluded at 95\% confidence level in the region of $0.01$ eV$^2 \lesssim |\Delta m^{2}_{41}| \lesssim 0.1 $ eV$^2$. This result represents the world-leading constraints in the region of $2 \times 10^{-4}$ eV$^2 \lesssim |\Delta m^{2}_{41}| \lesssim 0.2 $ eV$^2$., Comment: 7 pages, 4 figures, 1 table
Published: 2024

36. Aging mechanisms of NMC811/Si-Graphite Li-ion batteries

Author: Laakso, Ekaterina, Efimova, Sofya, Colalongo, Mattia, Kauranen, Pertti, Lahtinen, Katja, Napolitano, Emilio, Ruiz, Vanesa, Moskon, Joze, Gabersck, Miran, Park, Juyeon, Seitz, Steffen, Kallio, Tanja, Laakso, Ekaterina, Efimova, Sofya, Colalongo, Mattia, Kauranen, Pertti, Lahtinen, Katja, Napolitano, Emilio, Ruiz, Vanesa, Moskon, Joze, Gabersck, Miran, Park, Juyeon, Seitz, Steffen, and Kallio, Tanja
Abstract: Electrode degradation processes at various Li-ion batteries' state-of-health (SoH 100 %, 80 %, 50 %, and 30 %) and cycling temperatures (5°C, 23°C, and 45°C) were investigated. For this purpose, the standard format of Li-ion cylindrical 18,650 batteries with Si-Graphite negative and LiNi0⋅8Co0⋅1Mn0⋅1O2 (NMC811) positive electrodes were cycled with registering battery parameters and the electrochemical impedance spectrum were recorded after every 200 cycles. Once reaching their end-of-life, electrodes from cycled batteries were subjected to post-mortem analysis. NMC811 positive electrode was observed to crack during the charge and discharge processes, suffered by irreversible phase transition, transition metal dissolution, cathode electrolyte interphase growth, and cation mixing. The Si-Graphite negative electrode material was also affected by crack formation, layer exfoliation, solid electrolyte interphase (SEI) recompositing, Li dendrite growth, transition metal contamination, and Si dissolution. Degradation of components leads to an increase of the contact resistance, Li+ diffusion limitations, reduction of active materials participating in Li-ion storage and, as a result, capacity fade that finally rendered the battery utilization unfeasible. Degradation processes can be detected by capacity fade and impedance growth of the full battery. High temperature accelerates electrode degradation processes when low temperature leads to SEI and Li dendrite growth.
Published: 2024
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37. Early management of adult traumatic spinal cord injury in patients with polytrauma : a consensus and clinical recommendations jointly developed by the World Society of Emergency Surgery (WSES) & the European Association of Neurosurgical Societies (EANS)

Author: Picetti, Edoardo, Demetriades, Andreas K., Catena, Fausto, Aarabi, Bizhan, Abu-Zidan, Fikri M., Alves, Oscar L., Ansaloni, Luca, Armonda, Rocco A., Badenes, Rafael, Bala, Miklosh, Balogh, Zsolt J., Barbanera, Andrea, Bertuccio, Alessandro, Biffl, Walter L., Bouzat, Pierre, Buki, Andras, Castano-Leon, Ana Maria, Cerasti, Davide, Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Costa, Francesco, De Iure, Federico, Depreitere, Bart, Fainardi, Enrico, Fehlings, Michael J., Gabrovsky, Nikolay, Godoy, Daniel Agustin, Gruen, Peter, Gupta, Deepak, Hawryluk, Gregory W. J., Helbok, Raimund, Hossain, Iftakher, Hutchinson, Peter J., Iaccarino, Corrado, Inaba, Kenji, Ivanov, Marcel, Kaprovoy, Stanislav, Kirkpatrick, Andrew W., Klein, Sam, Kolias, Angelos, Konovalov, Nikolay A., Lagares, Alfonso, Lippa, Laura, Loza-Gomez, Angelica, Luoto, Teemu M., Maas, Andrew I. R., Maciejczak, Andrzej, Maier, Ronald, V, Marklund, Niklas, Martin, Matthew J., Melloni, Ilaria, Mendoza-Lattes, Sergio, Meyfroidt, Geert, Munari, Marina, Napolitano, Lena M., Okonkwo, David O., Otomo, Yasuhiro, Papadopoulos, Marios C., Petr, Ondra, Peul, Wilco C., Pudkrong, Aichholz K., Qasim, Zaffer, Rasulo, Frank, Reizinho, Carla, Ringel, Florian, Rizoli, Sandro, Rostami, Elham, Rubiano, Andres M., Russo, Emanuele, Sarwal, Aarti, Schwab, Jan M., Servadei, Franco, Sharma, Deepak, Sharif, Salman, Shiban, Ehab, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Terpolilli, Nicole A., Thome, Claudius, Toth, Peter, Tsitsopoulos, Parmenion P., Udy, Andrew, Vaccaro, Alexander R., Varon, Albert J., Vavilala, Monica S., Younsi, Alexander, Zackova, Monika, Zoerle, Tommaso, Robba, Chiara, Picetti, Edoardo, Demetriades, Andreas K., Catena, Fausto, Aarabi, Bizhan, Abu-Zidan, Fikri M., Alves, Oscar L., Ansaloni, Luca, Armonda, Rocco A., Badenes, Rafael, Bala, Miklosh, Balogh, Zsolt J., Barbanera, Andrea, Bertuccio, Alessandro, Biffl, Walter L., Bouzat, Pierre, Buki, Andras, Castano-Leon, Ana Maria, Cerasti, Davide, Citerio, Giuseppe, Coccolini, Federico, Coimbra, Raul, Coniglio, Carlo, Costa, Francesco, De Iure, Federico, Depreitere, Bart, Fainardi, Enrico, Fehlings, Michael J., Gabrovsky, Nikolay, Godoy, Daniel Agustin, Gruen, Peter, Gupta, Deepak, Hawryluk, Gregory W. J., Helbok, Raimund, Hossain, Iftakher, Hutchinson, Peter J., Iaccarino, Corrado, Inaba, Kenji, Ivanov, Marcel, Kaprovoy, Stanislav, Kirkpatrick, Andrew W., Klein, Sam, Kolias, Angelos, Konovalov, Nikolay A., Lagares, Alfonso, Lippa, Laura, Loza-Gomez, Angelica, Luoto, Teemu M., Maas, Andrew I. R., Maciejczak, Andrzej, Maier, Ronald, V, Marklund, Niklas, Martin, Matthew J., Melloni, Ilaria, Mendoza-Lattes, Sergio, Meyfroidt, Geert, Munari, Marina, Napolitano, Lena M., Okonkwo, David O., Otomo, Yasuhiro, Papadopoulos, Marios C., Petr, Ondra, Peul, Wilco C., Pudkrong, Aichholz K., Qasim, Zaffer, Rasulo, Frank, Reizinho, Carla, Ringel, Florian, Rizoli, Sandro, Rostami, Elham, Rubiano, Andres M., Russo, Emanuele, Sarwal, Aarti, Schwab, Jan M., Servadei, Franco, Sharma, Deepak, Sharif, Salman, Shiban, Ehab, Shutter, Lori, Stahel, Philip F., Taccone, Fabio S., Terpolilli, Nicole A., Thome, Claudius, Toth, Peter, Tsitsopoulos, Parmenion P., Udy, Andrew, Vaccaro, Alexander R., Varon, Albert J., Vavilala, Monica S., Younsi, Alexander, Zackova, Monika, Zoerle, Tommaso, and Robba, Chiara
Abstract: Background: The early management of polytrauma patients with traumatic spinal cord injury (tSCI) is a major challenge. Sparse data is available to provide optimal care in this scenario and worldwide variability in clinical practice has been documented in recent studies. Methods: A multidisciplinary consensus panel of physicians selected for their established clinical and scientific expertise in the acute management of tSCI polytrauma patients with different specializations was established. The World Society of Emergency Surgery (WSES) and the European Association of Neurosurgical Societies (EANS) endorsed the consensus, and a modified Delphi approach was adopted. Results: A total of 17 statements were proposed and discussed. A consensus was reached generating 17 recommendations (16 strong and 1 weak). Conclusions: This consensus provides practical recommendations to support a clinician's decision making in the management of tSCI polytrauma patients.
Published: 2024
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38. Annotation and Classification of Relevant Clauses in Terms-and-Conditions Contracts

Author: Bizzaro, Pietro Giovanni, Della Valentina, Elena, Napolitano, Maurizio, Mana, Nadia, Zancanaro, Massimo, Bizzaro, Pietro Giovanni, Della Valentina, Elena, Napolitano, Maurizio, Mana, Nadia, and Zancanaro, Massimo
Abstract: In this paper, we propose a new annotation scheme to classify different types of clauses in Terms-and-Conditions contracts with the ultimate goal of supporting legal experts to quickly identify and assess problematic issues in this type of legal documents. To this end, we built a small corpus of Terms-and-Conditions contracts and finalized an annotation scheme of 14 categories, eventually reaching an inter-annotator agreement of 0.92. Then, for 11 of them, we experimented with binary classification tasks using few-shot prompting with a multilingual T5 and two fine-tuned versions of two BERT-based LLMs for Italian. Our experiments showed the feasibility of automatic classification of our categories by reaching accuracies ranging from .79 to .95 on validation tasks., Comment: LREC-COLING 2024. https://aclanthology.org/2024.lrec-main.108
Published: 2024

39. Nuclear Physics Mid Term Plan at LNGS

Author: Buompane, R., Cavanna, F., Curceanu, C., D’Onofrio, A., Di Leva, A., Formicola, A., Gialanella, L., Gustavino, C., Imbriani, G., Junker, M., Marcianò, A., Marzaioli, F., Nania, R., Napolitano, F., Piscicchia, K., Straniero, O., Abia, C., Aliotta, M., Bemmerer, D., Best, A., (0000-0002-7209-2499) Boeltzig, A., Bruno, C., Caciolli, A., Chieffi, A., Ciani, G., D’Agata, G., Deboer, R. J., Cesare, M., Dell’Aquila, D., Depalo, R., Dominguez, I., Ferraro, F., Garcia Duarte, J., Guglielmetti, A., Gyürky, G., Hayakawa, S., La Cognata, M., Lamia, L., Marcucci, L. E., (0000-0002-6532-4255) Masha, E., Mazzocco, M., Morales-Gallegos, E. L., Palmerini, S., Passariello, I., Petraglia, A., Piatti, D., Pignatari, M., Pizzone, R. G., Porzio, G., Rapagnani, D., Rapisarda, G. G., Romano, S., Rubino, M., Santonastaso, C., Sergi, M. L., Skowronski, J., Spartà, R., Terrasi, F., Tumino, A., (0000-0002-0509-8743) Turkat, S., Wiescher, M., Zavatarelli, S., Buompane, R., Cavanna, F., Curceanu, C., D’Onofrio, A., Di Leva, A., Formicola, A., Gialanella, L., Gustavino, C., Imbriani, G., Junker, M., Marcianò, A., Marzaioli, F., Nania, R., Napolitano, F., Piscicchia, K., Straniero, O., Abia, C., Aliotta, M., Bemmerer, D., Best, A., (0000-0002-7209-2499) Boeltzig, A., Bruno, C., Caciolli, A., Chieffi, A., Ciani, G., D’Agata, G., Deboer, R. J., Cesare, M., Dell’Aquila, D., Depalo, R., Dominguez, I., Ferraro, F., Garcia Duarte, J., Guglielmetti, A., Gyürky, G., Hayakawa, S., La Cognata, M., Lamia, L., Marcucci, L. E., (0000-0002-6532-4255) Masha, E., Mazzocco, M., Morales-Gallegos, E. L., Palmerini, S., Passariello, I., Petraglia, A., Piatti, D., Pignatari, M., Pizzone, R. G., Porzio, G., Rapagnani, D., Rapisarda, G. G., Romano, S., Rubino, M., Santonastaso, C., Sergi, M. L., Skowronski, J., Spartà, R., Terrasi, F., Tumino, A., (0000-0002-0509-8743) Turkat, S., Wiescher, M., and Zavatarelli, S.
Abstract: The Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Gran Sasso (LNGS) is one of the largest underground physics laboratory, a very peculiar environment suited for experiments in Astroparticle Physics, Nuclear Physics and Fundamental Symmetries. The newly established Bellotti Ion Beam facility represents a major advance in the possibilities of studying nuclear processes in an underground environment. A workshop was organized at LNGS in the framework of the Nuclear Physics Mid Term Plan in Italy, an initiative of the Nuclear Physics Division of the Instituto Nazionale di Fisica Nucleare to discuss the opportunities that will be possible to study in the near future by employing state-of-the-art detection systems. In this report, a detailed discussion of the outcome of the workshop is presented.
Published: 2024

40. Switching from VEDOlizumab intravenous to subcutaneous formulation in ulcerative colitis patients in clinical remission: The SVEDO Study, an IG-IBD study

Author: Ribaldone, Davide Giuseppe, Parisio, Laura, Variola, Angela, Bossa, Fabrizio, Castiglione, Fabiana, Marzo, Manuela, Piazza, Nicole, Aratari, Annalisa, Savarino, Edoardo Vincenzo, Bodini, Giorgia, Mastronardi, Mauro, Micheli, Federica, Mazzuoli, Silvia, Ascolani, Marta, Viganò, Chiara, Cappello, Maria, Bezzio, Cristina, Ciccocioppo, Rachele, Scardino, Giulia, Sarli, Ennio, Pugliese, Daniela, Scaldaferri, Franco, Napolitano, Daniele, Todeschini, Alessia, Geccherle, Andrea, Colaci, Nicoletta, Guerra, Maria, Annese, Monica, Testa, Anna, Caiazzo, Anna, Conforti, Francesco Simone, Festa, Stefano, Lorenzon, Greta, Marra, Antonella, Magiotta, Ambra, Baccini, Flavia, Amato, Arnaldo, Poshnjari, Anxhela, Vernero, Marta, Caprioli, Flavio, Caviglia, Gian Paolo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Ribaldone, Davide Giuseppe, Parisio, Laura, Variola, Angela, Bossa, Fabrizio, Castiglione, Fabiana, Marzo, Manuela, Piazza, Nicole, Aratari, Annalisa, Savarino, Edoardo Vincenzo, Bodini, Giorgia, Mastronardi, Mauro, Micheli, Federica, Mazzuoli, Silvia, Ascolani, Marta, Viganò, Chiara, Cappello, Maria, Bezzio, Cristina, Ciccocioppo, Rachele, Scardino, Giulia, Sarli, Ennio, Pugliese, Daniela, Scaldaferri, Franco, Napolitano, Daniele, Todeschini, Alessia, Geccherle, Andrea, Colaci, Nicoletta, Guerra, Maria, Annese, Monica, Testa, Anna, Caiazzo, Anna, Conforti, Francesco Simone, Festa, Stefano, Lorenzon, Greta, Marra, Antonella, Magiotta, Ambra, Baccini, Flavia, Amato, Arnaldo, Poshnjari, Anxhela, Vernero, Marta, Caprioli, Flavio, Caviglia, Gian Paolo, and Scaldaferri, Franco (ORCID:0000-0001-8334-7541)
Abstract: Background: The administration of biological drugs in inflammatory bowel diseases (IBD) is increasingly moving from intravenous to subcutaneous formulations. Aims: To evaluate the efficacy and safety of vedolizumab subcutaneous administration after switching from intravenous administration in ulcerative colitis (UC) patients in corticosteroid-free clinical remission. Methods: An observational, multicentre, prospective study was conducted by the Italian Group for the study of IBD (IG-IBD). UC patients in clinical remission (pMAYO < 2) not receiving steroids for > 8 months before the switch, and with at least 6 months of follow-up were included. Switch from intravenous to subcutaneous vedolizumab was defined as successful in patients not experiencing a disease flare (pMAYO ≥ 2) or needing oral steroids or stopping subcutaneous vedolizumab during the 6 months of follow-up after the switch. Results: Overall, 168 patients were included. The switch was a success in 134 patients (79.8%). Vedolizumab retention rate was 88.7% at month six. C-reactive protein and faecal calprotectin values did not change after the switch (p = 0.07 and p = 0.28, respectively). Ten of the 19 patients who stopped subcutaneous formulation switched back to intravenous formulation recapturing clinical remission in 80%. Side effects were observed in 22 patients (13.1%). Conclusion: Effectiveness of switching from intravenous to subcutaneous vedolizumab formulation in UC patients in steroid-free clinical remission is confirmed in a real-world setting.
Published: 2024

41. Transition from intravenous to subcutaneous biological therapies in inflammatory bowel disease: An online survey of patients

Author: Napolitano, Daniele, Settanni, Carlo Romano, Parisio, Laura, Orgiana, Nicoletta, Poscia, Andrea, Schiavoni, Elisa, Turchini, Laura, Cascio, Alessio Lo, Germini, Francesco, Sblendorio, Elena, Milani, Alessandra, Patteril, Christopher, Laterza, Lucrezia, Lopetuso, Loris Riccardo, Pugliese, Daniela, Papa, Alfredo, Gasbarrini, Antonio, Scaldaferri, Franco, Poscia, Andrea (ORCID:0000-0002-7616-3389), Papa, Alfredo (ORCID:0000-0002-4186-7298), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Napolitano, Daniele, Settanni, Carlo Romano, Parisio, Laura, Orgiana, Nicoletta, Poscia, Andrea, Schiavoni, Elisa, Turchini, Laura, Cascio, Alessio Lo, Germini, Francesco, Sblendorio, Elena, Milani, Alessandra, Patteril, Christopher, Laterza, Lucrezia, Lopetuso, Loris Riccardo, Pugliese, Daniela, Papa, Alfredo, Gasbarrini, Antonio, Scaldaferri, Franco, Poscia, Andrea (ORCID:0000-0002-7616-3389), Papa, Alfredo (ORCID:0000-0002-4186-7298), Gasbarrini, Antonio (ORCID:0000-0002-7278-4823), and Scaldaferri, Franco (ORCID:0000-0001-8334-7541)
Abstract: BackgroundThe transition from in-hospital intravenous administration to subcutaneous therapies to treat inflammatory bowel disease (IBD) can raise some concerns among patients due to the self-administration concerns, the management of potential side effects and the overall worries related to a change of treatment. This study aimed at evaluating patients' opinion about the switch from intravenous to subcutaneous formulations and their knowledge on new available therapeutic options.MethodsWe conducted a survey using a questionnaire prepared by a team of gastroenterologists and nurses working at the IBD unit. It consists of 31 items and has been divided into four sections: descriptive, commitment, knowledge and passage mode opinion. The questions were formulated in Italian and conceived according to daily consultations with patients in everyday practice, without any previous piloting or specific medical literature reference. The survey was administered to consecutive IBD patients in intravenous biological treatment; patients currently or previously treated with subcutaneous therapy were excluded.ResultsFour hundred questionnaires were distributed to participants. As many as 311 patients (77.7%) completed the survey, while the remaining were excluded from the analysis; 155 (49.8%) patients were favorable to switch from intravenous to subcutaneous therapy, while only 78 (25.1%) disagreed. In univariate and multi-variate analysis, the approval rate for home therapy was significantly associated with the distance from the IBD center and work/family/personal commitments. Surprisingly, only a quarter of the IBD patients knew that almost all available therapeutic agents have a subcutaneous administration route. Regarding patients' opinion on the efficacy of subcutaneous administration of biological agents compared to intravenous drugs, 194 (63%) had no definite idea, while 44 (14%) believed that the effectiveness could be reduced.ConclusionThe transition from in-hospital to su
Published: 2024

42. Ustekinumab safety and effectiveness in patients with ulcerative colitis: results from a large real-life study

Author: Tursi, Antonio, Mocci, Giammarco, Scaldaferri, Franco, Napolitano, Daniele, Maresca, Rossella, Pugliese, Daniela, Semprucci, Gianluca, Savarino, Edoardo, Cuomo, Antonio, Donnarumma, Laura, Bodini, Giorgia, Pasta, Andrea, Maconi, Giovanni, Cataletti, Giovanni, Pranzo, Giuseppe, Rodinò, Stefano, Sebkova, Ladislava, Costa, Francesco, Ferronato, Antonio, Gaiani, Federica, Marzo, Manuela, Luppino, Ileana, Fabiano, Giulia, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Grossi, Laurino, Serio, Mariaelena, Scarcelli, Antonella, Lorenzetti, Roberto, Allegretta, Leonardo, Chiri, Stefania, Grasso, Giuseppina, Antonelli, Elisabetta, Bassotti, Gabrio, Spagnuolo, Rocco, Luzza, Francesco, Fanigliulo, Libera, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Rocchi, Chiara, Bolognini, Laura, Bendia, Emanuele, Bianco, Maria Antonia, Capone, Pietro, Meucci, Costantino, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Della Valle, Nicola, Felice, Carla, Pica, Roberta, Cocco, Andrea, Forti, Giacomo, Onidi, Francesca Maria, Usai Satta, Paolo, Checchin, Davide, Gravina, Antonietta Gerarda, Pellegrino, Raffaele, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), Papa, Alfredo (ORCID:0000-0002-4186-7298), Tursi, Antonio, Mocci, Giammarco, Scaldaferri, Franco, Napolitano, Daniele, Maresca, Rossella, Pugliese, Daniela, Semprucci, Gianluca, Savarino, Edoardo, Cuomo, Antonio, Donnarumma, Laura, Bodini, Giorgia, Pasta, Andrea, Maconi, Giovanni, Cataletti, Giovanni, Pranzo, Giuseppe, Rodinò, Stefano, Sebkova, Ladislava, Costa, Francesco, Ferronato, Antonio, Gaiani, Federica, Marzo, Manuela, Luppino, Ileana, Fabiano, Giulia, Paese, Pietro, Elisei, Walter, Monterubbianesi, Rita, Faggiani, Roberto, Grossi, Laurino, Serio, Mariaelena, Scarcelli, Antonella, Lorenzetti, Roberto, Allegretta, Leonardo, Chiri, Stefania, Grasso, Giuseppina, Antonelli, Elisabetta, Bassotti, Gabrio, Spagnuolo, Rocco, Luzza, Francesco, Fanigliulo, Libera, Rocco, Giulia, Sacchi, Carlotta, Zampaletta, Costantino, Rocchi, Chiara, Bolognini, Laura, Bendia, Emanuele, Bianco, Maria Antonia, Capone, Pietro, Meucci, Costantino, Colucci, Raffaele, Tonti, Paolo, Neve, Viviana, Della Valle, Nicola, Felice, Carla, Pica, Roberta, Cocco, Andrea, Forti, Giacomo, Onidi, Francesca Maria, Usai Satta, Paolo, Checchin, Davide, Gravina, Antonietta Gerarda, Pellegrino, Raffaele, Picchio, Marcello, Papa, Alfredo, Scaldaferri, Franco (ORCID:0000-0001-8334-7541), and Papa, Alfredo (ORCID:0000-0002-4186-7298)
Abstract: BackgroundUstekinumab (UST) is an interleukin-12/interleukin-23 receptor antagonist recently approved for treating ulcerative colitis (UC) but with limited real-world data. Therefore, we evaluated the effectiveness and safety of UST in patients with UC in a real-world setting.Research design and methodsThis is a multicenter, retrospective, observational cohort study. The primary endpoints were the clinical remission rate (partial Mayo score, PMS, <= 1) and the safety of UST. Other endpoints were corticosteroid-free remission (CSFR) rate, clinical response rate (PMS reduction of at least 2 points), and fecal calprotectin (FC) reduction at week 24.ResultsWe included 256 consecutive patients with UC (M/F 139/117, median age 52). The clinical remission and clinical response rates at eight weeks were 18.7% (44/235) and 53.2% (125/235), respectively, and 27.6% (42/152) and 61.8% (94/152) at 24 weeks, respectively. At 24 weeks, CSFR was 20.3% (31/152), and FC significantly dropped at week 12 (p = 0.0004) and 24 (p = 0.038). At eight weeks, patients naive or with one previous biologic treatment showed higher remission (p = 0.002) and clinical response rates (p = 0.018) than patients previously treated with >= 2. Adverse events occurred in six patients (2.3%), whereas four patients (1.6%) underwent colectomy.ConclusionThis real-world study shows that UST effectively and safely treats patients with UC.
Published: 2024

43. Measuring proximity to standard planes during fetal brain ultrasound scanning

Author: Di Vece, Chiara, Cirigliano, Antonio, Lous, Meala Le, Napolitano, Raffaele, David, Anna L., Peebles, Donald, Jannin, Pierre, Vasconcelos, Francisco, Stoyanov, Danail, Di Vece, Chiara, Cirigliano, Antonio, Lous, Meala Le, Napolitano, Raffaele, David, Anna L., Peebles, Donald, Jannin, Pierre, Vasconcelos, Francisco, and Stoyanov, Danail
Abstract: This paper introduces a novel pipeline designed to bring ultrasound (US) plane pose estimation closer to clinical use for more effective navigation to the standard planes (SPs) in the fetal brain. We propose a semi-supervised segmentation model utilizing both labeled SPs and unlabeled 3D US volume slices. Our model enables reliable segmentation across a diverse set of fetal brain images. Furthermore, the model incorporates a classification mechanism to identify the fetal brain precisely. Our model not only filters out frames lacking the brain but also generates masks for those containing it, enhancing the relevance of plane pose regression in clinical settings. We focus on fetal brain navigation from 2D ultrasound (US) video analysis and combine this model with a US plane pose regression network to provide sensorless proximity detection to SPs and non-SPs planes; we emphasize the importance of proximity detection to SPs for guiding sonographers, offering a substantial advantage over traditional methods by allowing earlier and more precise adjustments during scanning. We demonstrate the practical applicability of our approach through validation on real fetal scan videos obtained from sonographers of varying expertise levels. Our findings demonstrate the potential of our approach to complement existing fetal US technologies and advance prenatal diagnostic practices., Comment: 11 pages, 5 figures
Published: 2024

44. SEMA6C: a novel adhesion-independent FAK and YAP activator, required for cancer cell viability and growth

Author: Fard, Damon, Testa, Erika, Panzeri, Valentina, Rizzolio, Sabrina, Bianchetti, Giada, Napolitano, Virginia, Masciarelli, Silvia, Fazi, Francesco, Maulucci, Giuseppe, Scicchitano, Bianca Maria, Sette, Claudio, Viscomi, Maria Teresa, Tamagnone, Luca, Damon Fard, Erika Testa, Valentina Panzeri, Sabrina Rizzolio, Giada Bianchetti, Virginia Napolitano, Silvia Masciarelli, Francesco Fazi, Giuseppe Maulucci (ORCID:0000-0002-2154-319X), Bianca Maria Scicchitano (ORCID:0000-0002-9599-6642), Claudio Sette (ORCID:0000-0003-2864-8266), Maria Teresa Viscomi (ORCID:0000-0002-9096-4967), Luca Tamagnone (ORCID:0000-0002-2884-7946), Fard, Damon, Testa, Erika, Panzeri, Valentina, Rizzolio, Sabrina, Bianchetti, Giada, Napolitano, Virginia, Masciarelli, Silvia, Fazi, Francesco, Maulucci, Giuseppe, Scicchitano, Bianca Maria, Sette, Claudio, Viscomi, Maria Teresa, Tamagnone, Luca, Damon Fard, Erika Testa, Valentina Panzeri, Sabrina Rizzolio, Giada Bianchetti, Virginia Napolitano, Silvia Masciarelli, Francesco Fazi, Giuseppe Maulucci (ORCID:0000-0002-2154-319X), Bianca Maria Scicchitano (ORCID:0000-0002-9599-6642), Claudio Sette (ORCID:0000-0003-2864-8266), Maria Teresa Viscomi (ORCID:0000-0002-9096-4967), and Luca Tamagnone (ORCID:0000-0002-2884-7946)
Abstract: Transmembrane semaphorins are signaling molecules, controlling axonal wiring and embryo development, which are increasingly implicated in human diseases. Semaphorin 6C (Sema6C) is a poorly understood family member and its functional role is still unclear. Upon targeting Sema6C expression in a range of cancer cells, we observed dramatic growth suppression, decreased ERK phosphorylation, upregulation of cell cycle inhibitor proteins p21, p27 and p53, and the onset of cell senescence, associated with activation of autophagy. These data are consistent with a fundamental requirement for Sema6C to support viability and growth in cancer cells. Mechanistically, we unveiled a novel signaling pathway elicited by Sema6C, and dependent on its intracellular domain, mediated by tyrosine kinases c-Abl and Focal Adhesion Kinase (FAK). Sema6C was found in complex with c-Abl, and induced its phosphorylation, which in turn led to FAK activation, independent of cell-matrix adhesion. Sema6C-induced FAK activity was furthermore responsible for increased nuclear localization of YAP transcriptional regulator. Moreover, Sema6C conferred YAP signaling-dependent long-term cancer cell survival upon nutrient deprivation. In conclusion, our findings demonstrate that Sema6C elicits a cancer promoting-signaling pathway sustaining cell viability and self-renewal, independent of growth factors and nutrients availability.
Published: 2023

45. Reduced prevalence of fetal exposure to alcohol in Italy: a nationwide survey

Author: Camandona, F, Vaccari, L, Travan, L, Maso, G, Stampalija, T, Zanazzo, L, Pisana, P, Driul, L, Barbui, E, Caissutti, C, Valente, E, Ricchi, A, Bettiga, E, Piccolo, E, Pati, M, Pedori, S, Antonazzo, P, Sottile, G, Lo Faro, F, Tini, A, Massacesi, M, Rapisarda, C, Vivirito, G, Pinna, G, D'Anna, M, Klein, L, Bucolo, A, D'Anna, R, Monaco, C, La Ferrera, G, Capobianco, G, Olzai, M, Angioni, S, D'Alterio, M, Serravalle, P, Vicquery, C, Scalchi, S, Morando, C, Meneghin, M, Scapolan, C, Maggino, T, Guarinoni, B, Cristina Napolitano, G, De Vita, M, Di Carlo, C, Interlandi, F, Bisceglia, M, Michelangelo, B, Arnulfo, A, Finale, E, Marozio, L, Natali, I, Grazia, S, Staffler, A, Tarani, L, Coriale, G, Messina, M, D'Angelo, A, Bonito, M, Haass, C, Capasso, L, Raimondi, F, De Bernardo, G, Iacobelli, P, Spadarella, S, Enrica, M, Rabuano, R, Calzatini, F, Bossi, A, Aversa, S, Prefumo, F, Bellan, C, Leone, G, Ciammella, M, Von-Wunster, S, Liguori, A, Ornaghi, S, Fumagalli, S, Sanguineti, F, Gianola, G, Cagnacci, A, Amidani, A, Sisto, A, Di Marcello, F, Santillo, V, Di Bartolomeo, C, Gerli, S, Cagnoli, G, Petrisano, M, Pesce, S, Di Lascio, N, Falvino, S, Appio, P, Targiani, V, Cavaliere, A, Turrini, I, Belli, G, Beatrice, G, Florio, P, Innocenti, E, Magi, L, Civitelli, F, Nappi, L, Sorrentino, F, Silvestris, T, Indrio, F, Laforgia, N, Rizzo, V, La Rocca, M, Pradal, U, Memo, L, Diaz, C, Riscica, P, Bazzo, S, La Maida, N, Di Giorgi, A, Pellegrini, M, Ceccanti, M, Caruso, S, Ricci, G, Neri, I, Lana, S, Minutillo, A, Berretta, P, Busardo, F, Pichini, S, Camandona F., Vaccari L., Travan L., Maso G., Stampalija T., Zanazzo L., Pisana P., Driul L., Barbui E., Caissutti C., Valente E., Ricchi A., Bettiga E., Piccolo E., Pati M., Pedori S., Antonazzo P., Sottile G., Lo Faro F., Tini A., Massacesi M., Rapisarda C., Vivirito G., Pinna G., D'anna M., Klein L., Bucolo A., D'Anna R., Monaco C., La Ferrera G., Capobianco G., Olzai M. G., Angioni S., D'Alterio M. N., Serravalle P., Vicquery C., Scalchi S., Morando C., Meneghin M., Scapolan C., Maggino T., Guarinoni B., Cristina Napolitano G. M., De Vita M. G., Di Carlo C., Interlandi F., Bisceglia M., Michelangelo B., Arnulfo A., Finale E., Marozio L., Natali I., Grazia S. M., Staffler A., Tarani L., Coriale G., Messina M. P., D'Angelo A., Bonito M., Haass C., Capasso L., Raimondi F., De Bernardo G., Iacobelli P., Spadarella S., Enrica M., Rabuano R., Calzatini F., Bossi A., Aversa S., Prefumo F., Bellan C., Leone G., Ciammella M., Von-Wunster S., Liguori A., Ornaghi S., Fumagalli S., Sanguineti F., Gianola G., Cagnacci A., Amidani A., Sisto A., Di Marcello F., Santillo V., Di Bartolomeo C., Gerli S., Cagnoli G., Petrisano M., Pesce S., Di Lascio N., Falvino S., Appio P., Targiani V., Cavaliere A. F., Turrini I., Belli G., Beatrice G., Florio P., Innocenti E. D., Magi L., Civitelli F., Nappi L., Sorrentino F., Silvestris T., Indrio F., Laforgia N., Rizzo V., La Rocca M., Pradal U., Memo L., Diaz C., Riscica P., Bazzo S., La Maida N., Di Giorgi A., Pellegrini M., Ceccanti M., Caruso S., Ricci G., Neri I., Lana S., Minutillo A., Berretta P., Busardo F. P., Pichini S., Camandona, F, Vaccari, L, Travan, L, Maso, G, Stampalija, T, Zanazzo, L, Pisana, P, Driul, L, Barbui, E, Caissutti, C, Valente, E, Ricchi, A, Bettiga, E, Piccolo, E, Pati, M, Pedori, S, Antonazzo, P, Sottile, G, Lo Faro, F, Tini, A, Massacesi, M, Rapisarda, C, Vivirito, G, Pinna, G, D'Anna, M, Klein, L, Bucolo, A, D'Anna, R, Monaco, C, La Ferrera, G, Capobianco, G, Olzai, M, Angioni, S, D'Alterio, M, Serravalle, P, Vicquery, C, Scalchi, S, Morando, C, Meneghin, M, Scapolan, C, Maggino, T, Guarinoni, B, Cristina Napolitano, G, De Vita, M, Di Carlo, C, Interlandi, F, Bisceglia, M, Michelangelo, B, Arnulfo, A, Finale, E, Marozio, L, Natali, I, Grazia, S, Staffler, A, Tarani, L, Coriale, G, Messina, M, D'Angelo, A, Bonito, M, Haass, C, Capasso, L, Raimondi, F, De Bernardo, G, Iacobelli, P, Spadarella, S, Enrica, M, Rabuano, R, Calzatini, F, Bossi, A, Aversa, S, Prefumo, F, Bellan, C, Leone, G, Ciammella, M, Von-Wunster, S, Liguori, A, Ornaghi, S, Fumagalli, S, Sanguineti, F, Gianola, G, Cagnacci, A, Amidani, A, Sisto, A, Di Marcello, F, Santillo, V, Di Bartolomeo, C, Gerli, S, Cagnoli, G, Petrisano, M, Pesce, S, Di Lascio, N, Falvino, S, Appio, P, Targiani, V, Cavaliere, A, Turrini, I, Belli, G, Beatrice, G, Florio, P, Innocenti, E, Magi, L, Civitelli, F, Nappi, L, Sorrentino, F, Silvestris, T, Indrio, F, Laforgia, N, Rizzo, V, La Rocca, M, Pradal, U, Memo, L, Diaz, C, Riscica, P, Bazzo, S, La Maida, N, Di Giorgi, A, Pellegrini, M, Ceccanti, M, Caruso, S, Ricci, G, Neri, I, Lana, S, Minutillo, A, Berretta, P, Busardo, F, Pichini, S, Camandona F., Vaccari L., Travan L., Maso G., Stampalija T., Zanazzo L., Pisana P., Driul L., Barbui E., Caissutti C., Valente E., Ricchi A., Bettiga E., Piccolo E., Pati M., Pedori S., Antonazzo P., Sottile G., Lo Faro F., Tini A., Massacesi M., Rapisarda C., Vivirito G., Pinna G., D'anna M., Klein L., Bucolo A., D'Anna R., Monaco C., La Ferrera G., Capobianco G., Olzai M. G., Angioni S., D'Alterio M. N., Serravalle P., Vicquery C., Scalchi S., Morando C., Meneghin M., Scapolan C., Maggino T., Guarinoni B., Cristina Napolitano G. M., De Vita M. G., Di Carlo C., Interlandi F., Bisceglia M., Michelangelo B., Arnulfo A., Finale E., Marozio L., Natali I., Grazia S. M., Staffler A., Tarani L., Coriale G., Messina M. P., D'Angelo A., Bonito M., Haass C., Capasso L., Raimondi F., De Bernardo G., Iacobelli P., Spadarella S., Enrica M., Rabuano R., Calzatini F., Bossi A., Aversa S., Prefumo F., Bellan C., Leone G., Ciammella M., Von-Wunster S., Liguori A., Ornaghi S., Fumagalli S., Sanguineti F., Gianola G., Cagnacci A., Amidani A., Sisto A., Di Marcello F., Santillo V., Di Bartolomeo C., Gerli S., Cagnoli G., Petrisano M., Pesce S., Di Lascio N., Falvino S., Appio P., Targiani V., Cavaliere A. F., Turrini I., Belli G., Beatrice G., Florio P., Innocenti E. D., Magi L., Civitelli F., Nappi L., Sorrentino F., Silvestris T., Indrio F., Laforgia N., Rizzo V., La Rocca M., Pradal U., Memo L., Diaz C., Riscica P., Bazzo S., La Maida N., Di Giorgi A., Pellegrini M., Ceccanti M., Caruso S., Ricci G., Neri I., Lana S., Minutillo A., Berretta P., Busardo F. P., and Pichini S.
Published: 2023

46. How future surgery will benefit from SARS-COV-2-related measures: a SPIGC survey conveying the perspective of Italian surgeons

Author: Siragusa, L, Angelico, R, Angrisani, M, Zampogna, B, Materazzo, M, Sorge, R, Giordano, L, Meniconi, R, Coppola, A, Marino, A, Giraudo, G, Esposito, S, Urbani, A, De Pastena, M, Mastrapasqua, R, Garancini, M, Frontal, A, Pascal, G, Martellucc, J, Falb, F, Boscarelli, A, Bertoglio, P, Trecca, E, Galassi, L, Vento, V, Chiappini, A, Antonelli, A, Bennardo, F, Familiari, F, Giannaccare, G, Zappia, A, Giuliani, G, Falcone, F, Sebastiani, S, Montuori, M, Rossi, S, Sagnotta, A, Giuliani, B, Imbriani, G, Restaino, S, Andreani, L, Di Maria, F, Lagana, A, Vitiello, L, Berton, F, Virgilio, E, Palisi, M, Portigliotti, L, Calussi, M, Conti, L, Mauriello, C, Barone, M, Saladino, E, Giaquinta, A, Zerb, D, Frazzetta, G, Merola, G, Chierici, A, Bini, R, Centonze, L, De Carlis, R, Ferrario, L, Giani, A, Lauterio, A, Tamini, N, Corti, S, Botteri, E, Andreuccetti, J, D'Alessio, R, Cestaro, G, Clarizia, G, Spolini, A, Carboni, A, Benzoni, E, Galiffa, G, Perotti, B, Veroux, M, Randazzo, V, Topa, D, Pranteda, C, Contini, G, Iacusso, C, Voglino, V, Vita, P, Carrano, F, Ambrosio, L, Cammarata, R, Capolupo, G, Caputo, D, Carannante, F, Cascone, C, Esperto, F, Farolfi, T, Frasca, L, Gallo, I, Gibin, G, Giurazza, G, Improta, L, La Vaccara, V, Luffarelli, P, Luvero, D, Marangi, G, Masciana, G, Mazzola, A, Mazzotta, E, Miligi, C, Montelione, N, Nenna, A, Orsaria, P, Papalia, R, Papalia, G, Parisi, F, Prata, F, Salzillo, R, Santini, S, Sofo, F, Zampoli, A, Tanda, C, Altieri, G, Ardito, F, Belia, F, Bianchi, V, Biondi, A, Brisinda, G, Chiappetta, M, Ciolli, G, Ciolli, A, Ferracci, F, Ferri, L, Fico, V, Fiorillo, C, Fransvea, P, Galiandro, F, Giovinazzo, F, La Greca, A, Litta, F, Mele, C, Pafundi, D, Panettieri, E, Papa, V, Patini, R, Perrotta, G, Puccioni, C, Santocchi, P, Armatura, G, Olmi, S, Casoni Pattacini, G, Salgarello, S, Trompetto, M, Bombardini, C, La Rocca, R, Celentano, G, Micalef, A, Mazzella, A, Settembrini, A, Zoia, C, Degrate, L, Musumeci, G, Palopoli, C, Montori, G, Bonati, E, Dinuzzi, V, Velluti, F, Balla, A, Bonasia, D, Coletta, D, Berardi, G, Colasanti, M, Ferretti, S, Gasparoli, C, Mariano, G, Avenia, S, Cianci, P, Cestino, L, Festa, F, Fazio, F, Ascari, F, Desio, M, Arroyo Murillo, G, Cereda, M, Galleano, R, David, G, Pansini, A, Gazia, C, Atzori, G, Desideri, L, Famularo, S, Galvanin, J, Giudici, V, Mangiameli, G, Mei, S, Milana, F, Pansa, A, Sacchi, M, Testori, A, Di Carlo, G, Paratore, M, Perrone, U, Vagge, A, Vigano, J, Torre, B, Scotti, M, Carbone, G, Cerchione, R, De Nardi, P, Gozzini, L, Ottaviani, L, Senni, C, Piccin, O, Pio, L, Colombo, F, Avantifiori, R, Baldassarri, V, Caronna, R, Cicerchia, P, Corallino, D, Crocetti, D, Gallo, G, Giovanardi, F, Giovannetti, F, Hassan, R, Iossa, A, Lai, Q, Lancellotti, F, Lucarini, A, Lucchese, S, Mazzarella, G, Melandro, F, Minervini, A, Muttillo, E, Palmieri, L, Pasqua, R, Rosiello, F, Salina, G, Sibio, S, Sirignano, P, Tarallo, M, Usai, S, Vanni, C, Viglietta, E, Zambon, M, Conversano, N, Epifani, A, Milano, V, Sacco, L, Nava, M, Maffioli, A, Giuratrabocchetta, S, Baracchi, F, Zuolo, M, Ceresoli, M, Verdi, D, Belli, A, Pata, F, Piovano, E, Pastore, G, Bernabei, F, Deiana, S, Arceri, A, D'Agostino, C, Marafante, C, Moggia, E, Parini, S, Moretti, M, Uggeri, F, Pontarolo, N, Fontana, T, Palmisano, G, Giuffrida, M, Guaitoli, E, Ferretti, C, Iacopino, G, Gioco, R, Roscitano, G, Montanelli, P, Pinotti, E, Monati, E, Fazio, G, Di Pietro, F, Damarco, F, Barberis, A, Razzore, A, Pascale, A, Loi, S, Ferrara, F, Rossi, M, Lisi, G, Viel, G, Sasia, D, Bono, D, Cordaro, E, Giacomelli, E, Giani, I, Seriau, L, Pellino, G, Sparavigna, M, Trigiante, G, D'Ambrogio, R, Cardella, F, Guzzetti, S, Luzzi, A, Carganico, G, Drago, B, Micheletto, G, Orlandi, R, Cutolo, C, Gibello, U, Mistrangelo, M, Forcignano, E, D'Ugo, S, Losurdo, P, Manitto, M, Caroli, G, Franco, M, Tilocca, P, Mendogni, P, Sena, G, Sambucci, D, Luciani, C, Atelli, P, Guida, A, Marino, F, Morini, A, Sibilla, M, Longo, F, Giaccari, S, Vigorita, V, Balduzzi, A, Barra, F, Delogu, D, Milone, E, Bencini, L, Aprile, V, Papini, P, Montemurro, N, Cavallo, M, Picciariello, A, Tomasicchio, G, Fittipaldi, A, Maruccia, M, Gerardi, S, Cillara, N, Deidda, S, Demarinis, G, Peiretti, E, Tatti, F, Iovino, C, Isola, G, Progno, V, Migliore, M, Badessi, G, Barilla, C, Calleri, G, Cianci, S, Fama, F, Fleres, F, Mazzeo, C, Visaloco, M, Marchetto, C, Bolognesi, F, Benuzzi, L, Bracchetti, G, Brucchi, F, Manzo, C, Scaravilli, L, Ferrari, C, Rocca, A, Napolitano, P, Anoldo, P, Caricato, C, Manigrasso, M, Milone, M, Napolitano, L, Palomba, G, Schiavone, V, Vetrella, M, Grossi, U, Moletta, L, Annicchiarico, A, Vella, I, Talesa, G, Boggi, U, Aiello, F, Anselmo, A, Bacchiocchi, G, Beati, F, Bellato, V, Billeci, F, Blasi, F, Buonomo, O, Campanelli, M, Coco, G, Contadini, A, Conte, L, D'Ippolito, G, Di Marcantonio, A, Spicchiale, C, Afflitto, G, Gismondi, A, Gorgolini, G, Granai, A, Grande, S, Gravina, A, Ingallinella, S, Keci, L, Latini, E, Marino, D, Oddi, F, Orecchia, L, Don, C, Pellicciaro, M, Petagna, L, Pirozzi, B, Quaranta, C, Rho, M, Rosina, A, Santicchia, M, Saraceno, F, Schiavone, A, Sensi, B, Spina, A, Sullo, L, Tacconi, F, Taje, R, Vanni, G, Vinci, D, Vita, G, Alba, G, Badalucco, S, Carbone, L, Samorani, O, Chisci, G, Cuomo, R, Francia, A, Fusario, D, Gargiulo, B, Pasqui, E, Pasquetti, L, Puoti, P, Resca, L, Cumbo, J, Ganio, S, Vizzielli, G, Anastasi, M, Guerra, D, Romanzi, A, Vannelli, A, Baia, M, Siragusa L., Angelico R., Angrisani M., Zampogna B., Materazzo M., Sorge R., Giordano L., Meniconi R., Coppola A., Marino A., Giraudo G., Esposito S., Urbani A., De Pastena M., Mastrapasqua R., Garancini M., Frontal A., Pascal G., Martellucc J., Falb F., Boscarelli A., Bertoglio P., Trecca E., Galassi L., Vento V., Chiappini A., Antonelli A., Bennardo F., Familiari F., Giannaccare G., Zappia A. S., Giuliani G., Falcone F., Sebastiani S., Montuori M., Rossi S., Sagnotta A., Giuliani B., Imbriani G. C., Restaino S., Andreani L., Di Maria F., Lagana A. S., Vitiello L., Berton F., Virgilio E., Palisi M., Portigliotti L., Calussi M., Conti L., Mauriello C., Barone M., Saladino E., Giaquinta A., Zerb D., Frazzetta G., Merola G., Chierici A., Bini R., Centonze L., De Carlis R., Ferrario L., Giani A., Lauterio A., Tamini N., Corti S., Botteri E., Andreuccetti J., D'Alessio R., Cestaro G., Clarizia G., Spolini A., Carboni A. S., Benzoni E., Galiffa G., Perotti B., Veroux M., Randazzo V., Topa D., Pranteda C., Contini G., Iacusso C., Voglino V., Vita P., Carrano F. M., Ambrosio L., Cammarata R., Capolupo G. T., Caputo D., Carannante F., Cascone C., Esperto F., Farolfi T., Frasca L., Gallo I. F., Gibin G., Giurazza G., Improta L., La Vaccara V., Luffarelli P., Luvero D., Marangi G., Masciana G., Mazzola A., Mazzotta E., Miligi C. I., Montelione N., Nenna A., Orsaria P., Papalia R., Papalia G. F., Parisi F. R., Prata F., Salzillo R., Santini S., Sofo F., Zampoli A., Tanda C., Altieri G., Ardito F., Belia F., Bianchi V., Biondi A., Brisinda G., Chiappetta M., Ciolli G., Ciolli A., Ferracci F., Ferri L., Fico V., Fiorillo C., Fransvea P., Galiandro F., Giovinazzo F., La Greca A., Litta F., Mele C., Pafundi D. P., Panettieri E., Papa V., Patini R., Perrotta G., Puccioni C., Santocchi P., Armatura G., Olmi S., Casoni Pattacini G., Salgarello S., Trompetto M., Bombardini C., La Rocca R., Celentano G., Micalef A., Mazzella A., Settembrini A., Zoia C., Degrate L., Musumeci G., Palopoli C. A. M., Montori G., Bonati E., Dinuzzi V. P., Velluti F., Balla A., Bonasia D. E., Coletta D., Berardi G., Colasanti M., Ferretti S., Gasparoli C., Mariano G., Avenia S., Cianci P., Cestino L., Festa F., Fazio F., Ascari F., Desio M., Arroyo Murillo G. A., Cereda M., Galleano R., David G., Pansini A., Gazia C., Atzori G., Desideri L. F., Famularo S., Galvanin J., Giudici V. M., Mangiameli G., Mei S., Milana F., Pansa A., Sacchi M., Testori A., Di Carlo G., Paratore M., Perrone U., Vagge A., Vigano J., Torre B., Scotti M. A., Carbone G., Cerchione R., De Nardi P., Gozzini L., Ottaviani L., Senni C., Piccin O., Pio L., Colombo F., Avantifiori R., Baldassarri V., Caronna R., Cicerchia P. M., Corallino D., Crocetti D., Gallo G., Giovanardi F., Giovannetti F., Hassan R., Iossa A., Lai Q., Lancellotti F., Lucarini A., Lucchese S., Mazzarella G., Melandro F., Minervini A., Muttillo E. M., Palmieri L., Pasqua R., Rosiello F., Salina G., Sibio S., Sirignano P., Tarallo M., Usai S., Vanni C., Viglietta E., Zambon M., Conversano N. I., Epifani A. G., Milano V., Sacco L., Nava M., Maffioli A., Giuratrabocchetta S., Baracchi F., Zuolo M., Ceresoli M., Verdi D., Belli A., Pata F., Piovano E., Pastore G., Bernabei F., Deiana S., Arceri A., D'Agostino C., Marafante C., Moggia E., Parini S., Moretti M., Uggeri F., Pontarolo N., Fontana T., Palmisano G., Giuffrida M., Guaitoli E., Ferretti C., Iacopino G., Gioco R., Roscitano G., Montanelli P., Chiappetta M. F., Pinotti E., Monati E., Fazio G., Di Pietro F., Damarco F., Barberis A., Razzore A., Pascale A., Loi S., Ferrara F., Rossi M., Lisi G., Viel G., Sasia D., Bono D., Cordaro E. R., Giacomelli E., Giani I., Seriau L., Pellino G., Sparavigna M., Trigiante G., D'Ambrogio R. G., Cardella F., Guzzetti S., Luzzi A. -P., Carganico G., Drago B., Micheletto G., Orlandi R., Cutolo C., Gibello U., Mistrangelo M., Forcignano E., D'Ugo S., Losurdo P., Manitto M., Caroli G., Franco M., Tilocca P. L., Mendogni P., Sena G., Sambucci D., Luciani C., Atelli P., Guida A., Marino F., Morini A., Sibilla M. G., Longo F., Giaccari S., Vigorita V., Balduzzi A., Barra F., Delogu D., Milone E., Bencini L., Aprile V., Papini P., Montemurro N., Cavallo M., Picciariello A., Tomasicchio G., Fittipaldi A., Maruccia M., Gerardi S., Cillara N., Deidda S., Demarinis G., Peiretti E., Tatti F., Iovino C., Isola G., Progno V. C., Migliore M., Badessi G., Barilla C., Calleri G. S., Cianci S., Fama F., Fleres F., Mazzeo C., Visaloco M. G., Marchetto C., Bolognesi F., Benuzzi L., Bracchetti G., Brucchi F., Manzo C. A., Scaravilli L., Ferrari C., Rocca A., Napolitano P., Anoldo P., Caricato C., Manigrasso M., Milone M., Napolitano L., Palomba G., Schiavone V., Vetrella M., Grossi U., Moletta L., Annicchiarico A., Vella I., Talesa G., Boggi U., Aiello F., Anselmo A., Bacchiocchi G., Beati F., Bellato V., Billeci F., Blasi F., Buonomo O. C., Campanelli M., Coco G., Contadini A., Conte L. E., D'Ippolito G., Di Marcantonio A., Spicchiale C. F., Afflitto G. G., Gismondi A., Gorgolini G., Granai A. V., Grande S., Gravina A., Guida A. M., Ingallinella S., Keci L., Latini E., Marino D., Oddi F. M., Orecchia L., Don C. B. P., Pellicciaro M., Petagna L., Pirozzi B. M., Quaranta C., Rho M., Rosina A., Santicchia M. S., Saraceno F., Schiavone A., Sensi B., Spina A., Sullo L., Tacconi F., Taje R., Vanni G., Vinci D., Vita G., Alba G., Badalucco S., Carbone L., Samorani O. C., Chisci G., Cuomo R., Francia A., Fusario D., Gargiulo B., Pasqui E., Pasquetti L., Puoti P., Resca L., Cumbo J., Ganio S., Vizzielli G., Anastasi M., Guerra D., Romanzi A., Vannelli A., Baia M., Siragusa, L, Angelico, R, Angrisani, M, Zampogna, B, Materazzo, M, Sorge, R, Giordano, L, Meniconi, R, Coppola, A, Marino, A, Giraudo, G, Esposito, S, Urbani, A, De Pastena, M, Mastrapasqua, R, Garancini, M, Frontal, A, Pascal, G, Martellucc, J, Falb, F, Boscarelli, A, Bertoglio, P, Trecca, E, Galassi, L, Vento, V, Chiappini, A, Antonelli, A, Bennardo, F, Familiari, F, Giannaccare, G, Zappia, A, Giuliani, G, Falcone, F, Sebastiani, S, Montuori, M, Rossi, S, Sagnotta, A, Giuliani, B, Imbriani, G, Restaino, S, Andreani, L, Di Maria, F, Lagana, A, Vitiello, L, Berton, F, Virgilio, E, Palisi, M, Portigliotti, L, Calussi, M, Conti, L, Mauriello, C, Barone, M, Saladino, E, Giaquinta, A, Zerb, D, Frazzetta, G, Merola, G, Chierici, A, Bini, R, Centonze, L, De Carlis, R, Ferrario, L, Giani, A, Lauterio, A, Tamini, N, Corti, S, Botteri, E, Andreuccetti, J, D'Alessio, R, Cestaro, G, Clarizia, G, Spolini, A, Carboni, A, Benzoni, E, Galiffa, G, Perotti, B, Veroux, M, Randazzo, V, Topa, D, Pranteda, C, Contini, G, Iacusso, C, Voglino, V, Vita, P, Carrano, F, Ambrosio, L, Cammarata, R, Capolupo, G, Caputo, D, Carannante, F, Cascone, C, Esperto, F, Farolfi, T, Frasca, L, Gallo, I, Gibin, G, Giurazza, G, Improta, L, La Vaccara, V, Luffarelli, P, Luvero, D, Marangi, G, Masciana, G, Mazzola, A, Mazzotta, E, Miligi, C, Montelione, N, Nenna, A, Orsaria, P, Papalia, R, Papalia, G, Parisi, F, Prata, F, Salzillo, R, Santini, S, Sofo, F, Zampoli, A, Tanda, C, Altieri, G, Ardito, F, Belia, F, Bianchi, V, Biondi, A, Brisinda, G, Chiappetta, M, Ciolli, G, Ciolli, A, Ferracci, F, Ferri, L, Fico, V, Fiorillo, C, Fransvea, P, Galiandro, F, Giovinazzo, F, La Greca, A, Litta, F, Mele, C, Pafundi, D, Panettieri, E, Papa, V, Patini, R, Perrotta, G, Puccioni, C, Santocchi, P, Armatura, G, Olmi, S, Casoni Pattacini, G, Salgarello, S, Trompetto, M, Bombardini, C, La Rocca, R, Celentano, G, Micalef, A, Mazzella, A, Settembrini, A, Zoia, C, Degrate, L, Musumeci, G, Palopoli, C, Montori, G, Bonati, E, Dinuzzi, V, Velluti, F, Balla, A, Bonasia, D, Coletta, D, Berardi, G, Colasanti, M, Ferretti, S, Gasparoli, C, Mariano, G, Avenia, S, Cianci, P, Cestino, L, Festa, F, Fazio, F, Ascari, F, Desio, M, Arroyo Murillo, G, Cereda, M, Galleano, R, David, G, Pansini, A, Gazia, C, Atzori, G, Desideri, L, Famularo, S, Galvanin, J, Giudici, V, Mangiameli, G, Mei, S, Milana, F, Pansa, A, Sacchi, M, Testori, A, Di Carlo, G, Paratore, M, Perrone, U, Vagge, A, Vigano, J, Torre, B, Scotti, M, Carbone, G, Cerchione, R, De Nardi, P, Gozzini, L, Ottaviani, L, Senni, C, Piccin, O, Pio, L, Colombo, F, Avantifiori, R, Baldassarri, V, Caronna, R, Cicerchia, P, Corallino, D, Crocetti, D, Gallo, G, Giovanardi, F, Giovannetti, F, Hassan, R, Iossa, A, Lai, Q, Lancellotti, F, Lucarini, A, Lucchese, S, Mazzarella, G, Melandro, F, Minervini, A, Muttillo, E, Palmieri, L, Pasqua, R, Rosiello, F, Salina, G, Sibio, S, Sirignano, P, Tarallo, M, Usai, S, Vanni, C, Viglietta, E, Zambon, M, Conversano, N, Epifani, A, Milano, V, Sacco, L, Nava, M, Maffioli, A, Giuratrabocchetta, S, Baracchi, F, Zuolo, M, Ceresoli, M, Verdi, D, Belli, A, Pata, F, Piovano, E, Pastore, G, Bernabei, F, Deiana, S, Arceri, A, D'Agostino, C, Marafante, C, Moggia, E, Parini, S, Moretti, M, Uggeri, F, Pontarolo, N, Fontana, T, Palmisano, G, Giuffrida, M, Guaitoli, E, Ferretti, C, Iacopino, G, Gioco, R, Roscitano, G, Montanelli, P, Pinotti, E, Monati, E, Fazio, G, Di Pietro, F, Damarco, F, Barberis, A, Razzore, A, Pascale, A, Loi, S, Ferrara, F, Rossi, M, Lisi, G, Viel, G, Sasia, D, Bono, D, Cordaro, E, Giacomelli, E, Giani, I, Seriau, L, Pellino, G, Sparavigna, M, Trigiante, G, D'Ambrogio, R, Cardella, F, Guzzetti, S, Luzzi, A, Carganico, G, Drago, B, Micheletto, G, Orlandi, R, Cutolo, C, Gibello, U, Mistrangelo, M, Forcignano, E, D'Ugo, S, Losurdo, P, Manitto, M, Caroli, G, Franco, M, Tilocca, P, Mendogni, P, Sena, G, Sambucci, D, Luciani, C, Atelli, P, Guida, A, Marino, F, Morini, A, Sibilla, M, Longo, F, Giaccari, S, Vigorita, V, Balduzzi, A, Barra, F, Delogu, D, Milone, E, Bencini, L, Aprile, V, Papini, P, Montemurro, N, Cavallo, M, Picciariello, A, Tomasicchio, G, Fittipaldi, A, Maruccia, M, Gerardi, S, Cillara, N, Deidda, S, Demarinis, G, Peiretti, E, Tatti, F, Iovino, C, Isola, G, Progno, V, Migliore, M, Badessi, G, Barilla, C, Calleri, G, Cianci, S, Fama, F, Fleres, F, Mazzeo, C, Visaloco, M, Marchetto, C, Bolognesi, F, Benuzzi, L, Bracchetti, G, Brucchi, F, Manzo, C, Scaravilli, L, Ferrari, C, Rocca, A, Napolitano, P, Anoldo, P, Caricato, C, Manigrasso, M, Milone, M, Napolitano, L, Palomba, G, Schiavone, V, Vetrella, M, Grossi, U, Moletta, L, Annicchiarico, A, Vella, I, Talesa, G, Boggi, U, Aiello, F, Anselmo, A, Bacchiocchi, G, Beati, F, Bellato, V, Billeci, F, Blasi, F, Buonomo, O, Campanelli, M, Coco, G, Contadini, A, Conte, L, D'Ippolito, G, Di Marcantonio, A, Spicchiale, C, Afflitto, G, Gismondi, A, Gorgolini, G, Granai, A, Grande, S, Gravina, A, Ingallinella, S, Keci, L, Latini, E, Marino, D, Oddi, F, Orecchia, L, Don, C, Pellicciaro, M, Petagna, L, Pirozzi, B, Quaranta, C, Rho, M, Rosina, A, Santicchia, M, Saraceno, F, Schiavone, A, Sensi, B, Spina, A, Sullo, L, Tacconi, F, Taje, R, Vanni, G, Vinci, D, Vita, G, Alba, G, Badalucco, S, Carbone, L, Samorani, O, Chisci, G, Cuomo, R, Francia, A, Fusario, D, Gargiulo, B, Pasqui, E, Pasquetti, L, Puoti, P, Resca, L, Cumbo, J, Ganio, S, Vizzielli, G, Anastasi, M, Guerra, D, Romanzi, A, Vannelli, A, Baia, M, Siragusa L., Angelico R., Angrisani M., Zampogna B., Materazzo M., Sorge R., Giordano L., Meniconi R., Coppola A., Marino A., Giraudo G., Esposito S., Urbani A., De Pastena M., Mastrapasqua R., Garancini M., Frontal A., Pascal G., Martellucc J., Falb F., Boscarelli A., Bertoglio P., Trecca E., Galassi L., Vento V., Chiappini A., Antonelli A., Bennardo F., Familiari F., Giannaccare G., Zappia A. S., Giuliani G., Falcone F., Sebastiani S., Montuori M., Rossi S., Sagnotta A., Giuliani B., Imbriani G. C., Restaino S., Andreani L., Di Maria F., Lagana A. S., Vitiello L., Berton F., Virgilio E., Palisi M., Portigliotti L., Calussi M., Conti L., Mauriello C., Barone M., Saladino E., Giaquinta A., Zerb D., Frazzetta G., Merola G., Chierici A., Bini R., Centonze L., De Carlis R., Ferrario L., Giani A., Lauterio A., Tamini N., Corti S., Botteri E., Andreuccetti J., D'Alessio R., Cestaro G., Clarizia G., Spolini A., Carboni A. S., Benzoni E., Galiffa G., Perotti B., Veroux M., Randazzo V., Topa D., Pranteda C., Contini G., Iacusso C., Voglino V., Vita P., Carrano F. M., Ambrosio L., Cammarata R., Capolupo G. T., Caputo D., Carannante F., Cascone C., Esperto F., Farolfi T., Frasca L., Gallo I. F., Gibin G., Giurazza G., Improta L., La Vaccara V., Luffarelli P., Luvero D., Marangi G., Masciana G., Mazzola A., Mazzotta E., Miligi C. I., Montelione N., Nenna A., Orsaria P., Papalia R., Papalia G. F., Parisi F. R., Prata F., Salzillo R., Santini S., Sofo F., Zampoli A., Tanda C., Altieri G., Ardito F., Belia F., Bianchi V., Biondi A., Brisinda G., Chiappetta M., Ciolli G., Ciolli A., Ferracci F., Ferri L., Fico V., Fiorillo C., Fransvea P., Galiandro F., Giovinazzo F., La Greca A., Litta F., Mele C., Pafundi D. P., Panettieri E., Papa V., Patini R., Perrotta G., Puccioni C., Santocchi P., Armatura G., Olmi S., Casoni Pattacini G., Salgarello S., Trompetto M., Bombardini C., La Rocca R., Celentano G., Micalef A., Mazzella A., Settembrini A., Zoia C., Degrate L., Musumeci G., Palopoli C. A. M., Montori G., Bonati E., Dinuzzi V. P., Velluti F., Balla A., Bonasia D. E., Coletta D., Berardi G., Colasanti M., Ferretti S., Gasparoli C., Mariano G., Avenia S., Cianci P., Cestino L., Festa F., Fazio F., Ascari F., Desio M., Arroyo Murillo G. A., Cereda M., Galleano R., David G., Pansini A., Gazia C., Atzori G., Desideri L. F., Famularo S., Galvanin J., Giudici V. M., Mangiameli G., Mei S., Milana F., Pansa A., Sacchi M., Testori A., Di Carlo G., Paratore M., Perrone U., Vagge A., Vigano J., Torre B., Scotti M. A., Carbone G., Cerchione R., De Nardi P., Gozzini L., Ottaviani L., Senni C., Piccin O., Pio L., Colombo F., Avantifiori R., Baldassarri V., Caronna R., Cicerchia P. M., Corallino D., Crocetti D., Gallo G., Giovanardi F., Giovannetti F., Hassan R., Iossa A., Lai Q., Lancellotti F., Lucarini A., Lucchese S., Mazzarella G., Melandro F., Minervini A., Muttillo E. M., Palmieri L., Pasqua R., Rosiello F., Salina G., Sibio S., Sirignano P., Tarallo M., Usai S., Vanni C., Viglietta E., Zambon M., Conversano N. I., Epifani A. G., Milano V., Sacco L., Nava M., Maffioli A., Giuratrabocchetta S., Baracchi F., Zuolo M., Ceresoli M., Verdi D., Belli A., Pata F., Piovano E., Pastore G., Bernabei F., Deiana S., Arceri A., D'Agostino C., Marafante C., Moggia E., Parini S., Moretti M., Uggeri F., Pontarolo N., Fontana T., Palmisano G., Giuffrida M., Guaitoli E., Ferretti C., Iacopino G., Gioco R., Roscitano G., Montanelli P., Chiappetta M. F., Pinotti E., Monati E., Fazio G., Di Pietro F., Damarco F., Barberis A., Razzore A., Pascale A., Loi S., Ferrara F., Rossi M., Lisi G., Viel G., Sasia D., Bono D., Cordaro E. R., Giacomelli E., Giani I., Seriau L., Pellino G., Sparavigna M., Trigiante G., D'Ambrogio R. G., Cardella F., Guzzetti S., Luzzi A. -P., Carganico G., Drago B., Micheletto G., Orlandi R., Cutolo C., Gibello U., Mistrangelo M., Forcignano E., D'Ugo S., Losurdo P., Manitto M., Caroli G., Franco M., Tilocca P. L., Mendogni P., Sena G., Sambucci D., Luciani C., Atelli P., Guida A., Marino F., Morini A., Sibilla M. G., Longo F., Giaccari S., Vigorita V., Balduzzi A., Barra F., Delogu D., Milone E., Bencini L., Aprile V., Papini P., Montemurro N., Cavallo M., Picciariello A., Tomasicchio G., Fittipaldi A., Maruccia M., Gerardi S., Cillara N., Deidda S., Demarinis G., Peiretti E., Tatti F., Iovino C., Isola G., Progno V. C., Migliore M., Badessi G., Barilla C., Calleri G. S., Cianci S., Fama F., Fleres F., Mazzeo C., Visaloco M. G., Marchetto C., Bolognesi F., Benuzzi L., Bracchetti G., Brucchi F., Manzo C. A., Scaravilli L., Ferrari C., Rocca A., Napolitano P., Anoldo P., Caricato C., Manigrasso M., Milone M., Napolitano L., Palomba G., Schiavone V., Vetrella M., Grossi U., Moletta L., Annicchiarico A., Vella I., Talesa G., Boggi U., Aiello F., Anselmo A., Bacchiocchi G., Beati F., Bellato V., Billeci F., Blasi F., Buonomo O. C., Campanelli M., Coco G., Contadini A., Conte L. E., D'Ippolito G., Di Marcantonio A., Spicchiale C. F., Afflitto G. G., Gismondi A., Gorgolini G., Granai A. V., Grande S., Gravina A., Guida A. M., Ingallinella S., Keci L., Latini E., Marino D., Oddi F. M., Orecchia L., Don C. B. P., Pellicciaro M., Petagna L., Pirozzi B. M., Quaranta C., Rho M., Rosina A., Santicchia M. S., Saraceno F., Schiavone A., Sensi B., Spina A., Sullo L., Tacconi F., Taje R., Vanni G., Vinci D., Vita G., Alba G., Badalucco S., Carbone L., Samorani O. C., Chisci G., Cuomo R., Francia A., Fusario D., Gargiulo B., Pasqui E., Pasquetti L., Puoti P., Resca L., Cumbo J., Ganio S., Vizzielli G., Anastasi M., Guerra D., Romanzi A., Vannelli A., and Baia M.
Abstract: COVID-19 negatively affected surgical activity, but the potential benefits resulting from adopted measures remain unclear. The aim of this study was to evaluate the change in surgical activity and potential benefit from COVID-19 measures in perspective of Italian surgeons on behalf of SPIGC. A nationwide online survey on surgical practice before, during, and after COVID-19 pandemic was conducted in March–April 2022 (NCT:05323851). Effects of COVID-19 hospital-related measures on surgical patients’ management and personal professional development across surgical specialties were explored. Data on demographics, pre-operative/peri-operative/post-operative management, and professional development were collected. Outcomes were matched with the corresponding volume. Four hundred and seventy-three respondents were included in final analysis across 14 surgical specialties. Since SARS-CoV-2 pandemic, application of telematic consultations (4.1% vs. 21.6%; p < 0.0001) and diagnostic evaluations (16.4% vs. 42.2%; p < 0.0001) increased. Elective surgical activities significantly reduced and surgeons opted more frequently for conservative management with a possible indication for elective (26.3% vs. 35.7%; p < 0.0001) or urgent (20.4% vs. 38.5%; p < 0.0001) surgery. All new COVID-related measures are perceived to be maintained in the future. Surgeons’ personal education online increased from 12.6% (pre-COVID) to 86.6% (post-COVID; p < 0.0001). Online educational activities are considered a beneficial effect from COVID pandemic (56.4%). COVID-19 had a great impact on surgical specialties, with significant reduction of operation volume. However, some forced changes turned out to be benefits. Isolation measures pushed the use of telemedicine and telemetric devices for outpatient practice and favored communication for educational purposes and surgeon–patient/family communication. From the Italian surgeons’ perspective, COVID-related measures will continue to influence
Published: 2023

47. GRAd-COV2 vaccine provides potent and durable humoral and cellular immunity to SARS-CoV-2 in randomized placebo-controlled phase 2 trial

Author: Capone, S, Fusco, F, Milleri, S, Borre, S, Carbonara, S, Lo Caputo, S, Leone, S, Gori, G, Maggi, P, Cascio, A, Lichtner, M, Cauda, R, Dal Zoppo, S, Cossu, M, Gori, A, Roda, S, Confalonieri, P, Bonora, S, Missale, G, Codeluppi, M, Mezzaroma, I, Capici, S, Pontali, E, Libanore, M, Diani, A, Lanini, S, Battella, S, Contino, A, Piano Mortari, E, Genova, F, Parente, G, Dragonetti, R, Colloca, S, Visani, L, Iannacone, C, Carsetti, R, Folgori, A, Camerini, R, Ziviani, L, Malescio, F, Turrini, I, Lawlor, R, Romano, A, Nunziata, M, Armato, S, Mazzeo, N, Carleo, M, Dell'Isola, C, Pisapia, R, Pontarelli, A, Olivani, A, Grasselli, S, Laccabue, D, Leoni, M, Paolillo, F, Mancini, A, Ruaro, B, Confalonieri, M, Salton, F, Mancarella, G, Marocco, R, De Masi, M, Belvisi, V, Lamonica, S, Cingolani, A, Seguiti, C, Brambilla, P, Ferraresi, A, Lupi, M, Ludovisi, S, Renisi, G, Massafra, R, Pellicciotta, M, Armiento, L, Vimercati, S, Piacenza, M, Bonfanti, P, Columpsi, P, Cazzaniga, M, Rovelli, C, Ceresini, M, Previtali, L, Trentini, L, Alcantarini, C, Rugge, W, Biffi, S, Poletti, F, Rostagno, R, Moglia, R, De Negri, F, Fini, E, Cangialosi, A, Bruno, S, Rizzo, M, Niglio, M, Stritto, A, Matano, A, Petruzziello, A, Valsecchi, P, Pieri, T, Altamura, M, Calamo, A, Giannelli, A, Menolascina, S, Di Bari, S, Mauro, V, Aronica, R, Segala, D, Cultrera, R, Sighinolfi, L, Abbott, M, Gizzi, A, Marascia, F, Valenti, G, Feasi, M, Bobbio, N, Del Puente, F, Nicosia, A, Frasca, M, Mazzoleni, M, Garofalo, N, Ammendola, V, Grazioli, F, Napolitano, F, Vitelli, A, Marcellini, V, Capone S., Fusco F. M., Milleri S., Borre S., Carbonara S., Lo Caputo S., Leone S., Gori G., Maggi P., Cascio A., Lichtner M., Cauda R., Dal Zoppo S., Cossu M. V., Gori A., Roda S., Confalonieri P., Bonora S., Missale G., Codeluppi M., Mezzaroma I., Capici S., Pontali E., Libanore M., Diani A., Lanini S., Battella S., Contino A. M., Piano Mortari E., Genova F., Parente G., Dragonetti R., Colloca S., Visani L., Iannacone C., Carsetti R., Folgori A., Camerini R., Ziviani L., Malescio F., Turrini I., Lawlor R., Romano A., Nunziata M., Armato S., Mazzeo N., Carleo M. A., Dell'Isola C., Pisapia R., Pontarelli A., Olivani A., Grasselli S., Laccabue D., Leoni M. C., Paolillo F., Mancini A., Ruaro B., Confalonieri M., Salton F., Mancarella G., Marocco R., De Masi M., Belvisi V., Lamonica S., Cingolani A., Seguiti C., Brambilla P., Ferraresi A., Lupi M., Ludovisi S., Renisi G., Massafra R., Pellicciotta M., Armiento L., Vimercati S., Piacenza M., Bonfanti P., Columpsi P., Cazzaniga M. E., Rovelli C., Ceresini M., Previtali L., Trentini L., Alcantarini C., Rugge W., Biffi S., Poletti F., Rostagno R., Moglia R., De Negri F., Fini E., Cangialosi A., Bruno S. R., Rizzo M., Niglio M., Stritto A. D., Matano A., Petruzziello A., Valsecchi P., Pieri T., Altamura M., Calamo A., Giannelli A., Menolascina S., Di Bari S., Mauro V., Aronica R., Segala D., Cultrera R., Sighinolfi L., Abbott M., Gizzi A., Marascia F. G., Valenti G., Feasi M., Bobbio N., Del Puente F., Nicosia A., Frasca M., Mazzoleni M., Garofalo N., Ammendola V., Grazioli F., Napolitano F., Vitelli A., Marcellini V., Capone, S, Fusco, F, Milleri, S, Borre, S, Carbonara, S, Lo Caputo, S, Leone, S, Gori, G, Maggi, P, Cascio, A, Lichtner, M, Cauda, R, Dal Zoppo, S, Cossu, M, Gori, A, Roda, S, Confalonieri, P, Bonora, S, Missale, G, Codeluppi, M, Mezzaroma, I, Capici, S, Pontali, E, Libanore, M, Diani, A, Lanini, S, Battella, S, Contino, A, Piano Mortari, E, Genova, F, Parente, G, Dragonetti, R, Colloca, S, Visani, L, Iannacone, C, Carsetti, R, Folgori, A, Camerini, R, Ziviani, L, Malescio, F, Turrini, I, Lawlor, R, Romano, A, Nunziata, M, Armato, S, Mazzeo, N, Carleo, M, Dell'Isola, C, Pisapia, R, Pontarelli, A, Olivani, A, Grasselli, S, Laccabue, D, Leoni, M, Paolillo, F, Mancini, A, Ruaro, B, Confalonieri, M, Salton, F, Mancarella, G, Marocco, R, De Masi, M, Belvisi, V, Lamonica, S, Cingolani, A, Seguiti, C, Brambilla, P, Ferraresi, A, Lupi, M, Ludovisi, S, Renisi, G, Massafra, R, Pellicciotta, M, Armiento, L, Vimercati, S, Piacenza, M, Bonfanti, P, Columpsi, P, Cazzaniga, M, Rovelli, C, Ceresini, M, Previtali, L, Trentini, L, Alcantarini, C, Rugge, W, Biffi, S, Poletti, F, Rostagno, R, Moglia, R, De Negri, F, Fini, E, Cangialosi, A, Bruno, S, Rizzo, M, Niglio, M, Stritto, A, Matano, A, Petruzziello, A, Valsecchi, P, Pieri, T, Altamura, M, Calamo, A, Giannelli, A, Menolascina, S, Di Bari, S, Mauro, V, Aronica, R, Segala, D, Cultrera, R, Sighinolfi, L, Abbott, M, Gizzi, A, Marascia, F, Valenti, G, Feasi, M, Bobbio, N, Del Puente, F, Nicosia, A, Frasca, M, Mazzoleni, M, Garofalo, N, Ammendola, V, Grazioli, F, Napolitano, F, Vitelli, A, Marcellini, V, Capone S., Fusco F. M., Milleri S., Borre S., Carbonara S., Lo Caputo S., Leone S., Gori G., Maggi P., Cascio A., Lichtner M., Cauda R., Dal Zoppo S., Cossu M. V., Gori A., Roda S., Confalonieri P., Bonora S., Missale G., Codeluppi M., Mezzaroma I., Capici S., Pontali E., Libanore M., Diani A., Lanini S., Battella S., Contino A. M., Piano Mortari E., Genova F., Parente G., Dragonetti R., Colloca S., Visani L., Iannacone C., Carsetti R., Folgori A., Camerini R., Ziviani L., Malescio F., Turrini I., Lawlor R., Romano A., Nunziata M., Armato S., Mazzeo N., Carleo M. A., Dell'Isola C., Pisapia R., Pontarelli A., Olivani A., Grasselli S., Laccabue D., Leoni M. C., Paolillo F., Mancini A., Ruaro B., Confalonieri M., Salton F., Mancarella G., Marocco R., De Masi M., Belvisi V., Lamonica S., Cingolani A., Seguiti C., Brambilla P., Ferraresi A., Lupi M., Ludovisi S., Renisi G., Massafra R., Pellicciotta M., Armiento L., Vimercati S., Piacenza M., Bonfanti P., Columpsi P., Cazzaniga M. E., Rovelli C., Ceresini M., Previtali L., Trentini L., Alcantarini C., Rugge W., Biffi S., Poletti F., Rostagno R., Moglia R., De Negri F., Fini E., Cangialosi A., Bruno S. R., Rizzo M., Niglio M., Stritto A. D., Matano A., Petruzziello A., Valsecchi P., Pieri T., Altamura M., Calamo A., Giannelli A., Menolascina S., Di Bari S., Mauro V., Aronica R., Segala D., Cultrera R., Sighinolfi L., Abbott M., Gizzi A., Marascia F. G., Valenti G., Feasi M., Bobbio N., Del Puente F., Nicosia A., Frasca M., Mazzoleni M., Garofalo N., Ammendola V., Grazioli F., Napolitano F., Vitelli A., and Marcellini V.
Abstract: The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic and heterologous immunization approaches implemented worldwide for booster doses call for diversified vaccine portfolios. GRAd-COV2 is a gorilla adenovirus-based COVID-19 vaccine candidate encoding prefusion-stabilized spike. The safety and immunogenicity of GRAd-COV2 is evaluated in a dose- and regimen-finding phase 2 trial (COVITAR study, ClinicalTrials.gov: NCT04791423) whereby 917 eligible participants are randomized to receive a single intramuscular GRAd-COV2 administration followed by placebo, or two vaccine injections, or two doses of placebo, spaced over 3 weeks. Here, we report that GRAd-COV2 is well tolerated and induces robust immune responses after a single immunization; a second administration increases binding and neutralizing antibody titers. Potent, variant of concern (VOC) cross-reactive spike-specific T cell response peaks after the first dose and is characterized by high frequencies of CD8s. T cells maintain immediate effector functions and high proliferative potential over time. Thus, GRAd vector is a valuable platform for genetic vaccine development, especially when robust CD8 response is needed.
Published: 2023

48. Power of GIS Mapping: ATLAS Flood Maps 2022 (Short Paper)

Author: Munazza Usmani and Hafiz Muhammad Tayyab Bhatti and Francesca Bovolo and Maurizio Napolitano, Usmani, Munazza, Bhatti, Hafiz Muhammad Tayyab, Bovolo, Francesca, Napolitano, Maurizio, Munazza Usmani and Hafiz Muhammad Tayyab Bhatti and Francesca Bovolo and Maurizio Napolitano, Usmani, Munazza, Bhatti, Hafiz Muhammad Tayyab, Bovolo, Francesca, and Napolitano, Maurizio
Abstract: In this paper, we are introducing an efficient method based on the GIS technology, to design data immediate and analysis-ready mapping from open GIS and remote sensing data, vector and raster data into a single visualization to facilitate fast and flexible mapping, also referred to as ATLAS maps. The Google Earth Engine approach is used to pre-process the satellite data, while ArcGIS software is to integrate all the data layers. Since the ArcGIS software is included as a default dependency in GIS and remote sensing data, the proposed method provides a cross-platform and single-technology solution for handling flood mapping. For now, we conducted flood analysis using the latest open data for Pakistan and Nigeria countries, then elaborated on the advantages of each data for flood mapping with respect to inundated areas, rainfall analysis, and affected populations, health, and education facilities. Given a wide range of tasks that can benefit from the method, future work will extend the methodology to heterogeneous geodata (vector and raster) to support seamless and make it automatic interfaces.
Published: 2023
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49. Assessing micro-macroparasite selective pressures and anthropogenic disturbance as drivers of immune gene diversity in a Neotropical wild cat

Author: Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), National Geographic Society, Morris Animal Foundation, Mohamed bin Zayed Species Conservation Fund, Australian Government, Wild Felid Association, Napolitano, Constanza [0000-0002-7081-6975], Sacristán, Irene [0000-0002-4169-4884], López-Jara, María José [0000-0002-9646-6483], Hidalgo-Hermoso, Ezequiel [0000-0002-1291-514X], Poulin, Elie [0000-0001-7736-0969], Grueber, Catherine E. [0000-0002-8179-1822], Napolitano, Constanza, Sacristán, Irene, Acuña, Francisca, Aguilar, Emilio, García, Sebastián, López-Jara, María José, Cabello-Stom, Javier, Hidalgo-Hermoso, Ezequiel, Poulin, Elie, Grueber, Catherine E., Fondo Nacional de Desarrollo Científico y Tecnológico (Chile), National Geographic Society, Morris Animal Foundation, Mohamed bin Zayed Species Conservation Fund, Australian Government, Wild Felid Association, Napolitano, Constanza [0000-0002-7081-6975], Sacristán, Irene [0000-0002-4169-4884], López-Jara, María José [0000-0002-9646-6483], Hidalgo-Hermoso, Ezequiel [0000-0002-1291-514X], Poulin, Elie [0000-0001-7736-0969], Grueber, Catherine E. [0000-0002-8179-1822], Napolitano, Constanza, Sacristán, Irene, Acuña, Francisca, Aguilar, Emilio, García, Sebastián, López-Jara, María José, Cabello-Stom, Javier, Hidalgo-Hermoso, Ezequiel, Poulin, Elie, and Grueber, Catherine E.
Abstract: Anthropogenic environmental change is reducing available habitat for wild species, providing novel selection pressures such as infectious diseases and causing species to interact in new ways. The potential for emerging infectious diseases and zoonoses at the interface between humans, domestic animals, and wild species is a key global concern. In vertebrates, diversity at the major histocompatibility complex MHC is critical to disease resilience, and its study in wild populations provides insights into eco-evolutionary dynamics that human activities alter. In natural populations, variation at MHC loci is partly maintained by balancing selection, driven by pathogenic selective pressures. We hypothesize that MHC genetic diversity differs between guigna populations inhabiting human-dominated landscapes (higher pathogen pressures) versus more natural habitats (lower pathogen pressures). We predict that MHC diversity in guignas would be highest in human-dominated landscapes compared with continuous forest habitats. We also expected to find higher MHC diversity in guignas infected with micro and macro parasites (higher parasite load) versus non infected guignas. We characterized for the first time the genetic diversity at three MHC class I and II exons in 128 wild guignas (Leopardus guigna) across their distribution range in Chile (32-46° S) and Argentina, representing landscapes with varying levels of human disturbance. We integrated MHC sequence diversity with multiple measures of anthropogenic disturbance and both micro and macro parasite infection data. We also assessed signatures of positive selection acting on MHC genes. We found significantly higher MHC class I diversity in guignas inhabiting landscapes where houses were present, and with lower percentage of vegetation cover, and also in animals with more severe cardiorespiratory helminth infection (richness and intensity) and micro-macroparasite co-infection. This comprehensive, landscape-level assessment further e
Published: 2023

50. Mutated axon guidance gene PLXNB2 sustains growth and invasiveness of stem cells isolated from cancers of unknown primary

Author: Brundu, Serena, Napolitano, Virginia, Franzolin, Giulia, Lo Cascio, Ettore, Mastrantonio, Roberta, Sardo, Gabriele, Cascardi, Eliano, Verginelli, Federica, Sarnataro, Sergio, Gambardella, Gennaro, Pisacane, Alberto, Arcovito, Alessandro, Boccaccio, Carla, M Comoglio, Paolo, Giraudo, Enrico, Tamagnone, Luca, Virginia Napolitano, Roberta Mastrantonio (ORCID:0000-0002-1764-457X), Alessandro Arcovito (ORCID:0000-0002-8384-4844), Luca Tamagnone (ORCID:0000-0002-2884-7946), Brundu, Serena, Napolitano, Virginia, Franzolin, Giulia, Lo Cascio, Ettore, Mastrantonio, Roberta, Sardo, Gabriele, Cascardi, Eliano, Verginelli, Federica, Sarnataro, Sergio, Gambardella, Gennaro, Pisacane, Alberto, Arcovito, Alessandro, Boccaccio, Carla, M Comoglio, Paolo, Giraudo, Enrico, Tamagnone, Luca, Virginia Napolitano, Roberta Mastrantonio (ORCID:0000-0002-1764-457X), Alessandro Arcovito (ORCID:0000-0002-8384-4844), and Luca Tamagnone (ORCID:0000-0002-2884-7946)
Abstract: The genetic changes sustaining the development of cancers of unknown primary (CUP) remain elusive. The whole-exome genomic profiling of 14 rigorously selected CUP samples did not reveal specific recurring mutation in known driver genes. However, by comparing the mutational landscape of CUPs with that of most other human tumor types, it emerged a consistent enrichment of changes in genes belonging to the axon guidance KEGG pathway. In particular, G842C mutation of PlexinB2 (PlxnB2) was predicted to be activating. Indeed, knocking down the mutated, but not the wild-type, PlxnB2 in CUP stem cells resulted in the impairment of self-renewal and proliferation in culture, as well as tumorigenic capacity in mice. Conversely, the genetic transfer of G842C-PlxnB2 was sufficient to promote CUP stem cell proliferation and tumorigenesis in mice. Notably, G842C-PlxnB2 expression in CUP cells was associated with basal EGFR phosphorylation, and EGFR blockade impaired the viability of CUP cells reliant on the mutated receptor. Moreover, the mutated PlxnB2 elicited CUP cell invasiveness, blocked by EGFR inhibitor treatment. In sum, we found that a novel activating mutation of the axon guidance gene PLXNB2 sustains proliferative autonomy and confers invasive properties to stem cells isolated from cancers of unknown primary, in EGFR-dependent manner.
Published: 2023

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