1. Rethinking Unconventional Translation in Neurodegeneration.
- Author
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Gao, Fen-Biao, Gao, Fen-Biao, Richter, Joel D, Cleveland, Don W, Gao, Fen-Biao, Gao, Fen-Biao, Richter, Joel D, and Cleveland, Don W
- Abstract
Eukaryotic translation is tightly regulated to ensure that protein production occurs at the right time and place. Recent studies on abnormal repeat proteins, especially in age-dependent neurodegenerative diseases caused by nucleotide repeat expansion, have highlighted or identified two forms of unconventional translation initiation: usage of AUG-like sites (near cognates) or repeat-associated non-AUG (RAN) translation. We discuss how repeat proteins may differ due to not just unconventional initiation, but also ribosomal frameshifting and/or imperfect repeat DNA replication, expansion, and repair, and we highlight how research on translation of repeats may uncover insights into the biology of translation and its contribution to disease.
- Published
- 2017