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1. Outdoor health intervention for refugees, migrants, and asylum-seekers: A mixed-methods pilot study

Author: Wendelboe-Nelson, C., Fisher, J.C., Straka, T.M., Sousa-Silva, R., Menzel, C., Alejandre, J.C., de Bell, S., Oh, Rui Ying Rachel, Bonn, Aletta, Marselle, M.R., Wendelboe-Nelson, C., Fisher, J.C., Straka, T.M., Sousa-Silva, R., Menzel, C., Alejandre, J.C., de Bell, S., Oh, Rui Ying Rachel, Bonn, Aletta, and Marselle, M.R.
Abstract: Despite the multifaceted and diverse challenges that refugees, migrants, and asylum-seekers experience when entering a new country, they remain notably underrepresented in the evaluation and understanding of the health and wellbeing impacts of outdoor health interventions. We addressed this knowledge gap by a mixed-methods evaluation (questionnaires, focus groups and photo elicitation activity) facilitated by a community researcher. Qualitative data (focus groups and photo elicitation activity) revealed that the participants saw the social component of outdoor activities as a critical factor in improving their wellbeing, an insight not captured by established quantitative wellbeing scales. Given the diverse backgrounds of refugee, migrant, and asylum-seeker populations, we underline the importance of a transdisciplinary, collaborative, and mixed-methods research approach.
Published: 2024

2. Spontaneous Chirality Flipping in an Orthogonal Spin-Charge Ordered Topological Magnet

Author: Miao, H., Bouaziz, J., Fabbris, G., Meier, W. R., Yang, F. Z., Li, H. X., Nelson, C., Vescovo, E., Zhang, S., Christianson, A. D., Lee, H. N., Zhang, Y., Batista, C. D., Bluegel, S., Miao, H., Bouaziz, J., Fabbris, G., Meier, W. R., Yang, F. Z., Li, H. X., Nelson, C., Vescovo, E., Zhang, S., Christianson, A. D., Lee, H. N., Zhang, Y., Batista, C. D., and Bluegel, S.
Abstract: The asymmetric distribution of chiral objects with opposite chirality is of great fundamental interest ranging from molecular biology to particle physics. In quantum materials, chiral states can build on inversionsymmetry -breaking lattice structures or emerge from spontaneous magnetic ordering induced by competing interactions. Although the handedness of a chiral state can be changed through external fields, a spontaneous chirality flipping has yet to be discovered. We present experimental evidence of chirality flipping via changing temperature in a topological magnet EuAl4, which features orthogonal spin density waves (SDW) and charge density waves (CDW). Using circular dichroism of Bragg peaks in the resonant magnetic x-ray scattering, we find that the chirality of the helical SDW flips through a first -order phase transition with modified SDW wavelength. Intriguingly, we observe that the CDW couples strongly with the SDW and displays a rare commensurate -to -incommensurate transition at the chirality flipping temperature. Combining with first -principles calculations and angle -resolved photoemission spectroscopy, our results support a Fermi surface origin of the helical SDW with intertwined spin, charge, and lattice degrees of freedom in EuAl4. Our results reveal an unprecedented spontaneous chirality flipping and lay the groundwork for a new functional manipulation of chirality through momentum -dependent spin -charge -lattice interactions.
Published: 2024

3. Breaking the cycle: Effect of a multi-agency maternity service redesign on reducing the over-representation of Aboriginal and Torres Strait Islander newborns in out-of-home care: A prospective, non-randomised, intervention study in urban Australia.

Author: O'Dea, B, Roe, Y, Gao, Y, Kruske, S, Nelson, C, Hickey, S, Carson, A, Watego, K, Currie, J, Blackman, R, Reynolds, M, Wilson, K, Costello, J, Kildea, S, O'Dea, B, Roe, Y, Gao, Y, Kruske, S, Nelson, C, Hickey, S, Carson, A, Watego, K, Currie, J, Blackman, R, Reynolds, M, Wilson, K, Costello, J, and Kildea, S
Abstract: BACKGROUND: Strategies to reduce over-representation of Indigenous children in out-of-home care must start in pregnancy given Indigenous babies are 6 % of infants (<1 year), yet 43 % of infants in out-of-home care. OBJECTIVE: To determine if an Indigenous-led, multi-agency, partnership redesign of maternity services decreases the likelihood of babies being removed at birth. PARTICIPANTS AND SETTING: Women carrying an Indigenous baby/babies who gave birth at the Mater Mothers' Public Hospital, Brisbane (2013-2019). METHODS: A prospective, non-randomised, intervention trial evaluated a multi-agency service redesign. Women pregnant with an Indigenous baby birthing at a tertiary hospital were offered standard care or Birthing in Our Community (BiOC) service. We compared likelihood of babies being removed by Child Protection Services (CPS) at birth by model of care. Inverse probability of treatment propensity score weighting controlled baseline confounders and calculated treatment effect. Standardized differences were calculated to assess balance of risk factors for each copy of multiple imputation. Australian New Zealand Clinical Trial Registry, ACTRN12618001365257. RESULTS: In 2013-2019, 1988 women gave birth to 2044 Indigenous babies, with 40 women having babies removed at birth (9 BiOC, 31 standard care). Adjusted odds of baby removal were significantly lower for mothers in BiOC compared to standard care (AOR 0.37, 95 % CI 0.16, 0.84). In total, 2.0 % of Indigenous babies were removed by CPS; eight times higher than non-Indigenous babies at the same hospital (0.25 %). CONCLUSIONS: BiOC reduced removals of newborn Indigenous babies likely disrupting generational cycles of CPS contact, trauma, and maltreatment, and contributing to short and long-term health and wellbeing benefits for mothers and babies.
Published: 2024

4. Breaking the cycle: Effect of a multi-agency maternity service redesign on reducing the over-representation of Aboriginal and Torres Strait Islander newborns in out-of-home care: A prospective, non-randomised, intervention study in urban Australia.

Author: O'Dea, B, Roe, Y, Gao, Y, Kruske, S, Nelson, C, Hickey, S, Carson, A, Watego, K, Currie, J, Blackman, R, Reynolds, M, Wilson, K, Costello, J, Kildea, S, O'Dea, B, Roe, Y, Gao, Y, Kruske, S, Nelson, C, Hickey, S, Carson, A, Watego, K, Currie, J, Blackman, R, Reynolds, M, Wilson, K, Costello, J, and Kildea, S
Abstract: BACKGROUND: Strategies to reduce over-representation of Indigenous children in out-of-home care must start in pregnancy given Indigenous babies are 6 % of infants (<1 year), yet 43 % of infants in out-of-home care. OBJECTIVE: To determine if an Indigenous-led, multi-agency, partnership redesign of maternity services decreases the likelihood of babies being removed at birth. PARTICIPANTS AND SETTING: Women carrying an Indigenous baby/babies who gave birth at the Mater Mothers' Public Hospital, Brisbane (2013-2019). METHODS: A prospective, non-randomised, intervention trial evaluated a multi-agency service redesign. Women pregnant with an Indigenous baby birthing at a tertiary hospital were offered standard care or Birthing in Our Community (BiOC) service. We compared likelihood of babies being removed by Child Protection Services (CPS) at birth by model of care. Inverse probability of treatment propensity score weighting controlled baseline confounders and calculated treatment effect. Standardized differences were calculated to assess balance of risk factors for each copy of multiple imputation. Australian New Zealand Clinical Trial Registry, ACTRN12618001365257. RESULTS: In 2013-2019, 1988 women gave birth to 2044 Indigenous babies, with 40 women having babies removed at birth (9 BiOC, 31 standard care). Adjusted odds of baby removal were significantly lower for mothers in BiOC compared to standard care (AOR 0.37, 95 % CI 0.16, 0.84). In total, 2.0 % of Indigenous babies were removed by CPS; eight times higher than non-Indigenous babies at the same hospital (0.25 %). CONCLUSIONS: BiOC reduced removals of newborn Indigenous babies likely disrupting generational cycles of CPS contact, trauma, and maltreatment, and contributing to short and long-term health and wellbeing benefits for mothers and babies.
Published: 2024

5. A scoping review of unexpected weight loss and cancer: risk, guidelines, and recommendations for follow-up in primary care.

Author: Martinez-Gutierrez, J, De Mendonca, L, Ly, P, Lee, A, Hunter, B, Manski-Nankervis, J-A, Chima, S, Daly, D, Fishman, G, Lim, FS, Wang, B, Nelson, C, Nicholson, B, Emery, J, Martinez-Gutierrez, J, De Mendonca, L, Ly, P, Lee, A, Hunter, B, Manski-Nankervis, J-A, Chima, S, Daly, D, Fishman, G, Lim, FS, Wang, B, Nelson, C, Nicholson, B, and Emery, J
Abstract: BACKGROUND: Cancer diagnoses often begin with consultations with general practitioners (GPs), but the nonspecific nature of symptoms can lead to delayed diagnosis. Unexpected weight loss (UWL) is a common nonspecific symptom linked to undiagnosed cancer, yet guidelines for its diagnostic assessment in general practice lack consistency. AIM: To synthesise evidence on the association between UWL and cancer diagnosis, and to review clinical guidelines and recommendations for assessing patients with UWL. DESIGN AND SETTINGS: Systematic search and analysis of studies conducted in primary care. METHOD: Four databases searched for peer-reviewed literature from 2012 to 2023. Two reviewers conducted all the steps. A narrative review was conducted detailing the evidence for UWL as a risk factor for undiagnosed cancer, existing clinical guidance, and recommended diagnostic approach. RESULTS: We included 25 studies involving 916,092 patients; 92% provided strong evidence of an association between UWL and undiagnosed cancer. The National Institute for Health Care and Excellence Cancer Guideline in the UK was frequently cited. General suggestions encompassed regular weight monitoring, family history, risk factor evaluation, additional signs and symptoms, and a comprehensive physical examination. Commonly recommended pathology tests included C-reactive protein, complete blood count, alkaline phosphatase, and thyroid-stimulating hormone. Immunochemical faecal occult blood test, abdominal ultrasound, and chest X-ray were also prevalent. One large cohort study provided age, sex, and differential diagnosis-specific recommendations. CONCLUSION: This evidence review informs recommendations for investigating patients with UWL and will contribute to a computer decision support tool implementation in primary care, enhancing UWL assessment and potentially facilitating earlier cancer diagnosis.
Published: 2024

6. Perceptions of primary care patients on the use of electronic clinical decision support tools to facilitate health care: A systematic review.

Author: He, W, Chima, S, Emery, J, Manski-Nankervis, J-A, Williams, I, Hunter, B, Nelson, C, Martinez-Gutierrez, J, He, W, Chima, S, Emery, J, Manski-Nankervis, J-A, Williams, I, Hunter, B, Nelson, C, and Martinez-Gutierrez, J
Abstract: OBJECTIVE: Electronic clinical decision support tools (eCDSTs) are interventions designed to facilitate clinical decision-making using targeted medical knowledge and patient information. While eCDSTs have been demonstrated to improve quality of care, there is a paucity of research relating to the acceptability of eCDSTs in primary care from the patients' perspective. This study aims to summarize current evidence relating to primary care patients' perceptions and experiences on the use of eCDSTs by their clinician to provide care. METHODS: Four databases (Medline, Embase, CINAHL and Cochrane Library) were searched for qualitative and quantitative studies with outcomes relating to patients' perceptions of the use of clinician-facing or shared-eCDSTs. Data extraction and critical appraisal using the Johanna Briggs Institute Critical Appraisal checklists were carried out independently by reviewers. Qualitative and quantitative outcomes were synthesized independently. We used Richardson et al. 'Patient Evaluation of Artificial Intelligence (AI) in Healthcare' framework for qualitative analysis. FINDINGS: 20 papers were included for synthesis. eCDSTs were generally well-regarded by patients. The key facilitators for use were promoting informed decision-making, prompting discussions, aiding clinical decision-making, and enabling information sharing. Key barriers for use were lack of holistic care, 'medicalized' language, and confidentiality concerns. CONCLUSION: Our study identified important aspects to consider in the development of future eCDSTs. Patients were generally positive regarding the use of eCDSTs; however, patient's perspectives should be included from the conception of new eCDSTs to ensure recommendations align with the needs of patients and clinicians. PRACTICE IMPLICATIONS: The study results contribute to ensuring the acceptability of eCDSTs for patients and their unique needs. Encouragement is given for future development to adopt and build upon these findi
Published: 2024

7. Nature-based social prescribing programmes: opportunities, challenges, and facilitators for implementation

Author: de Bell, S, Alejandre, J.C., Menzel, C, Sousa-Silva, R, Straka, T, Berzborn, S, Bürck-Gemassmer, M, Dallimer, Martin, Dayson, C, Fisher, Jessica C., Haywood, A, Herrmann, A, Immich, G, Keßler, C.S., Köhler, K, Lynch, M, Marx, V, Michalsen, A, Mudu, P, Napierala, H, Nawrath, M, Pfleger, S, Quitmann, C, Reeves, J.P., Rozario, K, Straff, W, Straff, K, Wendelboe-Nelson, C, Marselle, M., Oh, R.R.Y., Bonn, A, de Bell, S, Alejandre, J.C., Menzel, C, Sousa-Silva, R, Straka, T, Berzborn, S, Bürck-Gemassmer, M, Dallimer, Martin, Dayson, C, Fisher, Jessica C., Haywood, A, Herrmann, A, Immich, G, Keßler, C.S., Köhler, K, Lynch, M, Marx, V, Michalsen, A, Mudu, P, Napierala, H, Nawrath, M, Pfleger, S, Quitmann, C, Reeves, J.P., Rozario, K, Straff, W, Straff, K, Wendelboe-Nelson, C, Marselle, M., Oh, R.R.Y., and Bonn, A
Abstract: Evidence on the health benefits of spending time in nature has highlighted the importance of provision of blue and green spaces where people live. The potential for health benefits offered by nature exposure, however, extends beyond health promotion to health treatment. Social prescribing links people with health or social care needs to community-based, non-clinical health and social care interventions to improve health and wellbeing. Nature-based social prescribing (NBSP) is a variant that uses the health-promoting benefits of activities carried out in natural environments, such as gardening and walking. Much current NBSP practice has been developed in the UK, and there is increasing global interest in its implementation. This requires interventions to be adapted for different contexts, considering the needs of populations and the structure of healthcare systems. This paper presents results from an expert group participatory workshop involving 29 practitioners, researchers, and policymakers from the UK and Germany's health and environmental sectors. Using the UK and Germany, two countries with different healthcare systems and in different developmental stages of NBSP practice, as case studies, we analysed opportunities, challenges, and facilitators for the development and implementation of NBSP. We identified five overarching themes for developing, implementing, and evaluating NBSP: Capacity Building; Accessibility and Acceptability; Networks and Collaborations; Standardised Implementation and Evaluation; and Sustainability. We also discuss key strengths, weaknesses, opportunities, and threats for each overarching theme to understand how they could be developed to support NBSP implementation. NBSP could offer significant public health benefits using available blue and green spaces. We offer guidance on how NBSP implementation, from wider policy support to the design and evaluation of individual programmes, could be adapted to different contexts. This research could
Published: 2024

8. Nature-based social prescribing programmes: opportunities, challenges, and facilitators for implementation

Author: de Bell, S., Alejandre, J.C., Menzel, C., Sousa-Silva, R., Straka, T.M., Berzborn, S., Bürck-Gemassmer, M., Dallimer, M., Dayson, C., Fisher, J.C., Haywood, A., Herrmann, A., Immich, G., Keßler, C.S., Köhler, K., Lynch, M., Marx, V., Michalsen, A., Mudu, P., Napierala, H., Nawrath, M., Pfleger, S., Quitmann, C., Reeves, J.P., Rozario, Kevin, Straff, W., Walter, K., Wendelboe-Nelson, C., Marselle, M.R., Oh, Rui Ying Rachel, Bonn, Aletta, de Bell, S., Alejandre, J.C., Menzel, C., Sousa-Silva, R., Straka, T.M., Berzborn, S., Bürck-Gemassmer, M., Dallimer, M., Dayson, C., Fisher, J.C., Haywood, A., Herrmann, A., Immich, G., Keßler, C.S., Köhler, K., Lynch, M., Marx, V., Michalsen, A., Mudu, P., Napierala, H., Nawrath, M., Pfleger, S., Quitmann, C., Reeves, J.P., Rozario, Kevin, Straff, W., Walter, K., Wendelboe-Nelson, C., Marselle, M.R., Oh, Rui Ying Rachel, and Bonn, Aletta
Abstract: Background:Evidence on the health benefits of spending time in nature has highlighted the importance of provision of blue and green spaces where people live. The potential for health benefits offered by nature exposure, however, extends beyond health promotion to health treatment. Social prescribing links people with health or social care needs to community-based, non-clinical health and social care interventions to improve health and wellbeing. Nature-based social prescribing (NBSP) is a variant that uses the health-promoting benefits of activities carried out in natural environments, such as gardening and walking. Much current NBSP practice has been developed in the UK, and there is increasing global interest in its implementation. This requires interventions to be adapted for different contexts, considering the needs of populations and the structure of healthcare systems.Methods:This paper presents results from an expert group participatory workshop involving 29 practitioners, researchers, and policymakers from the UK and Germany’s health and environmental sectors. Using the UK and Germany, two countries with different healthcare systems and in different developmental stages of NBSP practice, as case studies, we analysed opportunities, challenges, and facilitators for the development and implementation of NBSP.Results:We identified five overarching themes for developing, implementing, and evaluating NBSPCapacity Building; Accessibility and Acceptability; Networks and Collaborations; Standardised Implementation and Evaluation; and Sustainability. We also discuss key strengths, weaknesses, opportunities, and threats for each overarching theme to understand how they could be developed to support NBSP implementation.Conclusions:NBSP could offer significant public health benefits using available blue and green spaces. We offer guidance on how NBSP implementation, from wider policy support to the design and evaluation of individual programmes, could be adapted to diffe
Published: 2024

9. Neural correlates of inhibitory control and associations with cognitive outcomes in Bangladeshi children exposed to early adversities

Author: Sullivan, E, Xie, W, Conte, S, Richards, J, Shama, T, Haque, R, Petri, W, Nelson, C, Sullivan E. F., Xie W., Conte S., Richards J. E., Shama T., Haque R., Petri W. A., Nelson C. A., Sullivan, E, Xie, W, Conte, S, Richards, J, Shama, T, Haque, R, Petri, W, Nelson, C, Sullivan E. F., Xie W., Conte S., Richards J. E., Shama T., Haque R., Petri W. A., and Nelson C. A.
Abstract: There is strong support for the view that children growing up in low-income homes typically evince poorer performance on tests of inhibitory control compared to those growing up in higher income homes. Unfortunately, the vast majority of the work documenting this association has been conducted in high-income countries. It is not yet known whether the mechanisms found to mediate this association would generalize to children in low- and middle-income countries, where the risks of exposure to extreme poverty and a wide range of both biological and psychosocial hazards may be greater. We examined relations among early adversity, neural correlates of inhibitory control, and cognitive outcomes in 154 5-year-old children living in Dhaka, Bangladesh, an area with a high prevalence of poverty. Participants completed a go/no-go task assessing inhibitory control and their behavioral and event-related potential responses were assessed. Cortical source analysis was performed. We collected measures of poverty, malnutrition, maternal mental health, psychosocial adversity, and cognitive skills. Supporting studies in high-income countries, children in this sample exhibited a longer N2 latency and higher P3 amplitude to the no-go versus go condition. Unexpectedly, children had a more pronounced N2 amplitude during go trials than no-go trials. The N2 latency was related to their behavioral accuracy on the go/no-go task. The P3 mean amplitude, behavioral accuracy, and reaction time during the task were all associated with intelligence-quotient (IQ) scores. Children who experienced higher levels of psychosocial adversity had lower accuracy on the task and lower IQ scores.
Published: 2022

10. Willingness to vaccinate children against COVID-19 declined during the pandemic.

Author: Goldman, R, Goldman, R, Hart, R, Bone, J, Seiler, M, Olson, P, Keitel, K, Manzano, S, Gualco, G, Krupik, D, Schroter, S, Weigert, R, Chung, S, Thompson, G, Muhammad, N, Shah, P, Gaucher, N, Hou, M, Griffiths, J, Lunoe, M, Evers, M, Pharisa Rochat, C, Nelson, C, Gal, M, Baumer-Mouradian, S, Goldman, R, Goldman, R, Hart, R, Bone, J, Seiler, M, Olson, P, Keitel, K, Manzano, S, Gualco, G, Krupik, D, Schroter, S, Weigert, R, Chung, S, Thompson, G, Muhammad, N, Shah, P, Gaucher, N, Hou, M, Griffiths, J, Lunoe, M, Evers, M, Pharisa Rochat, C, Nelson, C, Gal, M, and Baumer-Mouradian, S
Abstract: OBJECTIVES: To document the level of vaccine hesitancy in caregivers of children younger than 12 years of age over the course of the pandemic in Pediatric Emergency Departments (ED). Study design Ongoing multicenter, cross-sectional survey of caregivers presenting to 19 pediatric EDs in the USA, Canada, Israel, and Switzerland during first months of the pandemic (phase1), when vaccines were approved for adults (phase2) and most recently when vaccines were approved for children (phase3). RESULTS: Willingness to vaccinate rate declined over the study period (59.7%, 56.1% and 52.1% in the three phases). Caregivers who are fully vaccinated, who have higher education, and those worried their child had COVID-19 upon arrival to the ED, were more likely to plan to vaccinate in all three phases. Mothers were less likely to vaccinate early in the pandemic, but this hesitancy attenuated in later phases. Older caregivers were more willing to vaccinate, and caregivers of older children were less likely to vaccinate their children in phase 3. During the last phase, willingness to vaccinate was lowest in those who had a primary care provider but did not rely on their advice for medical decisions (34%). Those with no primary care provider and those who do and rely on their medical advice, had similar rates of willingness to vaccinate (55.1% and 52.1%, respectively). CONCLUSIONS: COVID-19 vaccine hesitancy is widespread and growing over time, and public health measures should further try to leverage identified factors associated with hesitancy in order to enhance vaccination rates among children.
Published: 2023

11. The orchestration of gene expression and the editing role of microRNA

Author: Incontinentieteam, Fossum, M., Kaefer, M., Herbst, K. W., Harper, L., Beckers, G. M.A., Nelson, C. P., Garriboli, M., Nieuwhof-Leppink, A., Bagli, D., Kalfa, N., ESPU Research Committee, Incontinentieteam, Fossum, M., Kaefer, M., Herbst, K. W., Harper, L., Beckers, G. M.A., Nelson, C. P., Garriboli, M., Nieuwhof-Leppink, A., Bagli, D., Kalfa, N., and ESPU Research Committee
Published: 2023

12. Investigation of light ion fusion reactions with plasma discharges (II)

Author: Schenkel, Thomas, Schenkel, Thomas, Persaud, Arun, Wang, H, Seidl, P, MacFayden, R, Nelson, C, Waldron, Lawrence, Vay, Jean-Luc, Ji, Qing, Deblonde, Gauthier, Wen, B, Chiang, Yet-Ming, MacLeod, Ben P, Schenkel, Thomas, Schenkel, Thomas, Persaud, Arun, Wang, H, Seidl, P, MacFayden, R, Nelson, C, Waldron, Lawrence, Vay, Jean-Luc, Ji, Qing, Deblonde, Gauthier, Wen, B, Chiang, Yet-Ming, and MacLeod, Ben P
Abstract: The scaling of reaction yields in light ion fusion to low reaction energies is important for our understanding of stellar fuel chains and the development of future energy technologies. Experiments become progressively more challenging at lower reaction energies due to the exponential drop of fusion cross sections below the Coulomb barrier. We report on experiments where deuterium-deuterium (D-D) fusion reactions are studied in a pulsed plasma in the glow discharge regime using a benchtop apparatus. We model plasma conditions using particle-in-cell codes. Advantages of this approach are relatively high peak ion currents and current densities (0.1 to several A/cm2) that can be applied to metal wire cathodes for several days. We detect neutrons from D-D reactions with scintillator-based detectors. For palladium targets, we find neutron yields as a function of cathode voltage that are over 100 times higher than yields expected for bare nuclei fusion at ion energies below 2 keV (center of mass frame). A possible explanation is a correction to the ion energy due to an electron screening potential of 1000±250 eV, which increases the probability for tunneling through the repulsive Coulomb barrier. Our compact, robust setup enables parametric studies of this effect at relatively low reaction energies.
Published: 2023

13. Developing and evaluating Birthing on Country services for First Nations Australians: the Building On Our Strengths (BOOSt) prospective mixed methods birth cohort study protocol.

Author: Haora, P, Roe, Y, Hickey, S, Gao, Y, Nelson, C, Allen, J, Briggs, M, Worner, F, Kruske, S, Watego, K, Maidment, S-J, Hartz, D, Sherwood, J, Barclay, L, Tracy, S, Tracy, M, Wilkes, L, West, R, Grant, N, Kildea, S, Haora, P, Roe, Y, Hickey, S, Gao, Y, Nelson, C, Allen, J, Briggs, M, Worner, F, Kruske, S, Watego, K, Maidment, S-J, Hartz, D, Sherwood, J, Barclay, L, Tracy, S, Tracy, M, Wilkes, L, West, R, Grant, N, and Kildea, S
Abstract: BACKGROUND: With the impact of over two centuries of colonisation in Australia, First Nations families experience a disproportionate burden of adverse pregnancy and birthing outcomes. First Nations mothers are 3-5 times more likely than other mothers to experience maternal mortality; babies are 2-3 times more likely to be born preterm, low birth weight or not to survive their first year. 'Birthing on Country' incorporates a multiplicity of interpretations but conveys a resumption of maternity services in First Nations Communities with Community governance for the best start to life. Redesigned services offer women and families integrated, holistic care, including carer continuity from primary through tertiary services; services coordination and quality care including safe and supportive spaces. The overall aim of Building On Our Strengths (BOOSt) is to facilitate and assess Birthing on Country expansion into two settings - urban and rural; with scale-up to include First Nations-operated birth centres. This study will build on our team's earlier work - a Birthing on Country service established and evaluated in an urban setting, that reported significant perinatal (and organisational) benefits, including a 37% reduction in preterm births, among other improvements. METHODS: Using community-based, participatory action research, we will collaborate to develop, implement and evaluate new Birthing on Country care models. We will conduct a mixed-methods, prospective birth cohort study in two settings, comparing outcomes for women having First Nations babies with historical controls. Our analysis of feasibility, acceptability, clinical and cultural safety, effectiveness and cost, will use data including (i) women's experiences collected through longitudinal surveys (three timepoints) and yarning interviews; (ii) clinical records; (iii) staff and stakeholder views and experiences; (iv) field notes and meeting minutes; and (v) costs data. The study includes a process, impact a
Published: 2023

14. Birthing on country service compared to standard care for First Nations Australians: a cost-effectiveness analysis from a health system perspective.

Author: Gao, Y, Roe, Y, Hickey, S, Chadha, A, Kruske, S, Nelson, C, Carson, A, Watego, K, Reynolds, M, Costello, J, Tracy, S, Kildea, S, Gao, Y, Roe, Y, Hickey, S, Chadha, A, Kruske, S, Nelson, C, Carson, A, Watego, K, Reynolds, M, Costello, J, Tracy, S, and Kildea, S
Abstract: BACKGROUND: Preterm birth is the leading cause of morbidity and mortality for children under five years with First Nations babies experiencing twice the rate of other Australians. The Birthing in Our Community (BiOC) service was implemented in a metropolitan centre in Australia and showed a significant reduction in preterm birth. We aimed to assess the cost-effectiveness of the BiOC service in reducing preterm births compared to Standard Care, from a health system perspective. METHODS: Women who were carrying a First Nations baby and attending the Mater Mothers Public Hospital (Brisbane, QLD, Australia) were allocated to either BiOC or Standard Care service. Birth records were extracted from the hospital's routinely collected and prospectively entered database. The time horizon extended from first presentation in pregnancy up to six weeks after birth for mothers and 28 days for infants, or until discharged from hospital. All direct antenatal, birth, postnatal and neonatal costs were included. The proportion of preterm birth was calculated, and cost was estimated in 2019 Australian dollars. The incremental cost and proportion of preterm birth differences were adjusted using inverse probability of treatment weighting methods. FINDINGS: Between Jan 1 2013, and Jun 30, 2019, 1816 mothers gave births to 1867 First Nations babies at the Mater Mothers Public Hospital. After exclusions, 1636 mother-baby pairs were included in the analyses: 840 in the Standard Care group and 796 in the BiOC service. Relative to Standard Care, the BiOC service was associated with a reduced proportion of preterm birth (-5.34%, [95% CI -8.69%, -1.98%]) and cost savings (-AU$4810, [95% CI -7519, -2101]) per mother-baby pair. The BiOC service was associated with better outcomes and cost less than Standard Care. INTERPRETATION: The BiOC service offers a cost-effective alternative to Standard Care in reducing preterm birth for Australian First Nations families. The cost savings were driven by less
Published: 2023

15. The orchestration of gene expression and the editing role of microRNA

Author: Fossum, M, Kaefer, M, Herbst, K W, Harper, L, Beckers, G M A, Nelson, C P, Garriboli, M, Nieuwhof-Leppink, A, Bagli, D, Kalfa, N, Fossum, M, Kaefer, M, Herbst, K W, Harper, L, Beckers, G M A, Nelson, C P, Garriboli, M, Nieuwhof-Leppink, A, Bagli, D, and Kalfa, N
Abstract: In this short educational communication the ESPU Research Committee presents the role of non-coding RNA and how these can affect gene expression. In particular we discuss the role of microRNA on post transcriptional changes and how these may cause pathological conditions within Pediatric Urology and how microRNA could be useful in future clinical practice.
Published: 2023

16. EUV brightenings in the quiet-Sun: Signatures in spectral and imaging data from the Interface Region Imaging Spectrograph

Author: Nelson, C. J., Auchère, F., Cuadrado, R. Aznar, Barczynski, K., Buchlin, E., Harra, L., Long, D. M., Parenti, S., Peter, H., Schühle, U., Schwanitz, C., Smith, P., Teriaca, L., Verbeeck, C., Zhukov, A. N., Berghmans, D., Nelson, C. J., Auchère, F., Cuadrado, R. Aznar, Barczynski, K., Buchlin, E., Harra, L., Long, D. M., Parenti, S., Peter, H., Schühle, U., Schwanitz, C., Smith, P., Teriaca, L., Verbeeck, C., Zhukov, A. N., and Berghmans, D.
Abstract: Localised transient EUV brightenings, sometimes named `campfires', occur throughout the quiet-Sun. However, there are still many open questions about such events, in particular regarding their temperature range and dynamics. In this article, we aim to determine whether any transition region response can be detected for small-scale EUV brightenings and, if so, to identify whether the measured spectra correspond to any previously reported bursts in the transition region, such as Explosive Events (EEs). EUV brightenings were detected in a ~29.4 minute dataset sampled by Solar Orbiter's Extreme Ultraviolet Imager on 8 March 2022 using an automated detection algorithm. Any potential transition region response was inferred through analysis of imaging and spectral data sampled through coordinated observations conducted by the Interface Region Imaging Spectrograph (IRIS). EUV brightenings display a range of responses in IRIS slit-jaw imager (SJI) data. Some events have clear signatures in the Mg II and Si IV SJI filters, whilst others have no discernible counterpart. Both extended and more complex EUV brightenings are found to, sometimes, have responses in IRIS SJI data. Examples of EUI intensities peaking before, during, and after their IRIS counterparts were found in lightcurves constructed co-spatial to EUV brightenings. Importantly, therefore, it is likely that not all EUV brightenings are driven in the same way, with some seemingly being magnetic reconnection driven and others not. A single EUV brightening occurred co-spatial to the IRIS slit, with its spectra matching the properties of EEs. EUV brightenings is a term used to describe a range of small-scale event in the solar corona. The physics responsible for all EUV brightenings is likely not the same and, therefore, more research is required to assess their importance towards global questions in the field, such as coronal heating., Comment: Accepted to A&A, 9 figures
Published: 2023
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17. The orchestration of gene expression and the editing role of microRNA

Author: Fossum, M, Kaefer, M, Herbst, K W, Harper, L, Beckers, G M A, Nelson, C P, Garriboli, M, Nieuwhof-Leppink, A, Bagli, D, Kalfa, N, Fossum, M, Kaefer, M, Herbst, K W, Harper, L, Beckers, G M A, Nelson, C P, Garriboli, M, Nieuwhof-Leppink, A, Bagli, D, and Kalfa, N
Abstract: In this short educational communication the ESPU Research Committee presents the role of non-coding RNA and how these can affect gene expression. In particular we discuss the role of microRNA on post transcriptional changes and how these may cause pathological conditions within Pediatric Urology and how microRNA could be useful in future clinical practice.
Published: 2023

18. Enabling the context for Aboriginal and Torres Strait Islander Community Controlled Birthing on Country services: Participatory action research.

Author: Roe, Y, Allen, J, Haora, P, Hickey, S, Briggs, M, Wilkes, L, Nelson, C, Watego, K, Coddington, R, Ireland, S, Kruske, S, Gao, Y, Kildea, S, Roe, Y, Allen, J, Haora, P, Hickey, S, Briggs, M, Wilkes, L, Nelson, C, Watego, K, Coddington, R, Ireland, S, Kruske, S, Gao, Y, and Kildea, S
Abstract: PROBLEM: Establishment of Birthing on Country services owned and governed by Aboriginal and Torres Strait Islander Community Controlled Health Services has been slow. BACKGROUND: Birthing on Country services have demonstrated health and cost benefits and require redesign of maternity care. During the Building On Our Strengths feasibility study, use of endorsed midwives and licensing of birth centres has proven difficult. QUESTION: What prevents Community Controlled Health Services from implementing Birthing on Country services in Queensland and New South Wales? METHODS: Participatory action research identified implementation barriers. We conducted iterative document analysis of instruments to inform government lobbying through synthesis of policy, economic, social, technological, legal, and environmental factors. FINDINGS: Through cycles of participatory action research, we analysed 17 documents: 1) policy barriers prevent Community Controlled Health Services from employing endorsed midwives to provide intrapartum care in public hospitals; 2) economic barriers include lack of sustainable funding stream and inadequate Medicare-billing for endorsed midwives; and 3) legal barriers require a medical practitioner in a birth centre. While social barriers (e.g., colonisation, medicalisation) underpin regulations, these were beyond the scope; technological and environmental barriers were not identified. DISCUSSION: Findings are consistent with the literature on barriers to midwifery practice. Recommendations include a national audit of barriers to Birthing on Country services including healthcare practice insurance, and development of a funding stream. Additionally, private maternity facility regulation must align with evidence on safe birth centre operation. CONCLUSION: Government can address barriers to scale-up of Aboriginal and Torres Strait Islander Community Controlled Birthing on Country services.
Published: 2023

19. Birthing on country service compared to standard care for First Nations Australians: a cost-effectiveness analysis from a health system perspective.

Author: Gao, Y, Roe, Y, Hickey, S, Chadha, A, Kruske, S, Nelson, C, Carson, A, Watego, K, Reynolds, M, Costello, J, Tracy, S, Kildea, S, Gao, Y, Roe, Y, Hickey, S, Chadha, A, Kruske, S, Nelson, C, Carson, A, Watego, K, Reynolds, M, Costello, J, Tracy, S, and Kildea, S
Abstract: BACKGROUND: Preterm birth is the leading cause of morbidity and mortality for children under five years with First Nations babies experiencing twice the rate of other Australians. The Birthing in Our Community (BiOC) service was implemented in a metropolitan centre in Australia and showed a significant reduction in preterm birth. We aimed to assess the cost-effectiveness of the BiOC service in reducing preterm births compared to Standard Care, from a health system perspective. METHODS: Women who were carrying a First Nations baby and attending the Mater Mothers Public Hospital (Brisbane, QLD, Australia) were allocated to either BiOC or Standard Care service. Birth records were extracted from the hospital's routinely collected and prospectively entered database. The time horizon extended from first presentation in pregnancy up to six weeks after birth for mothers and 28 days for infants, or until discharged from hospital. All direct antenatal, birth, postnatal and neonatal costs were included. The proportion of preterm birth was calculated, and cost was estimated in 2019 Australian dollars. The incremental cost and proportion of preterm birth differences were adjusted using inverse probability of treatment weighting methods. FINDINGS: Between Jan 1 2013, and Jun 30, 2019, 1816 mothers gave births to 1867 First Nations babies at the Mater Mothers Public Hospital. After exclusions, 1636 mother-baby pairs were included in the analyses: 840 in the Standard Care group and 796 in the BiOC service. Relative to Standard Care, the BiOC service was associated with a reduced proportion of preterm birth (-5.34%, [95% CI -8.69%, -1.98%]) and cost savings (-AU$4810, [95% CI -7519, -2101]) per mother-baby pair. The BiOC service was associated with better outcomes and cost less than Standard Care. INTERPRETATION: The BiOC service offers a cost-effective alternative to Standard Care in reducing preterm birth for Australian First Nations families. The cost savings were driven by less
Published: 2023

20. Empirical Study of Ground Proximity Effects for Small-scale Electroaerodynamic Thrusters

Author: Nations, Grant, Nelson, C. Luke, Drew, Daniel S., Nations, Grant, Nelson, C. Luke, and Drew, Daniel S.
Abstract: Electroaerodynamic (EAD) propulsion, where thrust is produced by collisions between electrostatically-accelerated ions and neutral air, is a potentially transformative method for indoor flight owing to its silent and solid-state nature. Like rotors, EAD thrusters exhibit changes in performance based on proximity to surfaces. Unlike rotors, they have no fragile and quickly spinning parts that have to avoid those surfaces; taking advantage of the efficiency benefits from proximity effects may be a route towards longer-duration indoor operation of ion-propelled fliers. This work presents the first empirical study of ground proximity effects for EAD propulsors, both individually and as quad-thruster arrays. It focuses on multi-stage ducted centimeter-scale actuators suitable for use on small robots envisioned for deployment in human-proximal and indoor environments. Three specific effects (ground, suckdown, and fountain lift), each occurring with a different magnitude at a different spacing from the ground plane, are investigated and shown to have strong dependencies on geometric parameters including thruster-to-thruster spacing, thruster protrusion from the fuselage, and inclusion of flanges or strakes. Peak thrust enhancement ranging from 300 to 600% is found for certain configurations operated in close proximity (0.2 mm) to the ground plane and as much as a 20% increase is measured even when operated centimeters away.
Published: 2023

21. High Aspect Ratio Multi-stage Ducted Electroaerodynamic Thrusters for Micro Air Vehicle Propulsion

Author: Nelson, C. Luke, Drew, Daniel S., Nelson, C. Luke, and Drew, Daniel S.
Abstract: Electroaerodynamic propulsion, where force is produced through collisions between electrostatically accelerated ions and neutral air molecules, is an attractive alternative to propeller- and flapping wing-based methods for micro air vehicle (MAV) flight due to its silent and solid-state nature. One major barrier to adoption is its limited thrust efficiency at useful disk loading levels. Ducted actuators comprising multiple serially-integrated acceleration stages are a potential solution, allowing individual stages to operate at higher efficiency while maintaining a useful total thrust, and potentially improving efficiency through various aerodynamic and fluid dynamic mechanisms. In this work, we investigate the effects of duct and emitter electrode geometries on actuator performance, then show how a combination of increasing cross-sectional aspect ratio and serial integration of multiple stages can be used to produce overall thrust densities comparable to commercial propulsors. An optimized five-stage device attains a thrust density of about 18 N/m$^2$ at a thrust efficiency of about 2 mN/W, among the highest values ever measured at this scale. We further show how this type of thruster can be integrated under the wings of a MAV-scale fixed wing platform, pointing towards future use as a distributed propulsion system.
Published: 2023

22. Search for new phenomena in three- or four-lepton events in pp collisions at √s=13 TeV with the ATLAS detector

Author: Aad, G., Abbott, B., Abbott, D. C., Abed Abud, A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., AbouZeid, O. S., Abramowicz, H., Abreu, H., Abulaiti, Y., Abusleme Hoffman, A. C., Acharya, B. S., Achkar, B., Adam, L., Adam Bourdarios, C., Adamczyk, L., Adamek, L., Adelman, J., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Agarwala, J., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Åkesson, T. P.A., Akimov, A. V., Al Khoury, K., Alberghi, G. L., Albert, J., Alconada Verzini, M. J., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Allaire, C., Allbrooke, B. M.M., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Alunno Camelia, E., Alvarez Estevez, M., Alviggi, M. G., Amaral Coutinho, Y., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amrouche, C. S., Anastopoulos, C., Andari, N., Andeen, T., Anders, J. K., Andrean, S. Y., Andreazza, A., Andrei, V., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J.A., Anulli, F., Aoki, M., Aparisi Pozo, J. A., Aparo, M. A., Aperio Bella, L., Aranzabal, N., Araujo Ferraz, V., Arcangeletti, C., Arce, A. T.H., Arena, E., Arguin, J. F., Argyropoulos, S., Arling, J. H., Armbruster, A. J., Armstrong, A., Arnaez, O., Arnold, H., Arrubarrena Tame, Z. P., Artoni, G., Asada, H., Asai, K., Asai, S., Asbah, N. A., Asimakopoulou, E. M., Asquith, L., Assahsah, J., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Atmasiddha, P. A., Augsten, K., Auricchio, S., Austrup, V. A., Avolio, G., Ayoub, M. K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Backman, F., Badea, A., Bagnaia, P., Bahrasemani, H., Bailey, A. J., Bailey, V. R., Baines, J. T., Bakalis, C., Baker, O. K., Bakker, P. J., Bakos, E., Bakshi Gupta, D., Balaji, S., Balasubramanian, R., Baldin, E. M., Balek, P., Ballabene, E., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Barak, L., Barberio, E. L., Barberis, D., Barbero, M., Barbour, G., Barends, K. N., Barillari, T., Barisits, M. S., Barkeloo, J., Barklow, T., Barnett, B. M., Barnett, R. M., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., Barreiro Guimarães da Costa, J., Barron, U., Barsov, S., Bartels, F., Bartoldus, R., Bartolini, G., Barton, A. E., Bartos, P., Basalaev, A., Basan, A., Bashta, I., Bassalat, A., Basso, M. J., Basson, C. R., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Bauce, M., Bauer, F., Bauer, P., Bawa, H. S., Bayirli, A., Beacham, J. B., Beau, T., Beauchemin, P. H., Becherer, F., Bechtle, P., Beck, H. P., Becker, K., Becot, C., Beddall, A. J., Bednyakov, V. A., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Beirao Da Cruz E Silva, C., Beirer, J. F., Beisiegel, F., Belfkir, M., Bella, G., Bellagamba, L., Bellerive, A., Bellos, P., Beloborodov, K., Belotskiy, K., Belyaev, N. L., Benchekroun, D., Benhammou, Y., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Bergeaas Kuutmann, E., Berger, N., Bergmann, B., Bergsten, L. J., Beringer, J., Berlendis, S., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Berthold, A., Bertram, I. A., Bessidskaia Bylund, O., Bethke, S., Betti, A., Bevan, A. J., Bhatta, S., Bhattacharya, D. S., Bhattarai, P., Bhopatkar, V. S., Bi, R., Bianchi, R. M., Biebel, O., Bielski, R., Biesuz, N. V., Biglietti, M., Billoud, T. R.V., Bindi, M., Bingul, A., Bini, C., Biondi, S., Birch-sykes, C. J., Bird, G. A., Birman, M., Bisanz, T., Biswal, J. P., Biswas, D., Bitadze, A., Bittrich, C., Bjørke, K., Bloch, I., Blocker, C., Blue, A., Blumenschein, U., Blumenthal, J., Bobbink, G. J., Bobrovnikov, V. S., Bogavac, D., Bogdanchikov, A. G., Bohm, C., Boisvert, V., Bokan, P., Bold, T., Bomben, M., Bona, M., Boonekamp, M., Booth, C. D., Borbély, A. G., Borecka-Bielska, H. M., Borgna, L. S., Borissov, G., Bortoletto, D., Boscherini, D., Bosman, M., Bossio Sola, J. D., Bouaouda, K., Boudreau, J., Bouhova-Thacker, E. V., Boumediene, D., Bouquet, R., Boveia, A., Boyd, J., Boye, D., Boyko, I. R., Bozson, A. J., Bracinik, J., Brahimi, N., Brandt, G., Brandt, O., Braren, F., Brau, B., Brau, J. E., Breaden Madden, W. D., Brendlinger, K., Brener, R., Brenner, L., Brenner, R., Bressler, S., Brickwedde, B., Briglin, D. L., Britton, D., Britzger, D., Brock, I., Brock, R., Brooijmans, G., Brooks, W. K., Brost, E., Bruckman de Renstrom, P. A., Brüers, B., Bruncko, D., Bruni, A., Bruni, G., Bruschi, M., Bruscino, N., Bryngemark, L., Buanes, T., Buat, Q., Buchholz, P., Buckley, A. G., Budagov, I. A., Bugge, M. K., Bulekov, O., Bullard, B. A., Burch, T. J., Burdin, S., Burgard, C. D., Burger, A. M., Burghgrave, B., Burr, J. T.P., Burton, C. D., Burzynski, J. C., Büscher, V., Bussey, P. J., Butler, J. M., Buttar, C. M., Butterworth, J. M., Buttinger, W., Buxo Vazquez, C. J., Buzykaev, A. R., Cabras, G., Cabrera Urbán, S., Caforio, D., Cai, H., Cairo, V. M.M., Cakir, O., Calace, N., Calafiura, P., Calderini, G., Calfayan, P., Callea, G., Caloba, L. P., Caltabiano, A., Calvente Lopez, S., Calvet, D., Calvet, S., Calvet, T. P., Calvetti, M., Camacho Toro, R., Camarda, S., Camarero Munoz, D., Camarri, P., Camerlingo, M. T., Cameron, D., Camincher, C., Campanelli, M., Camplani, A., Canale, V., Canesse, A., Cano Bret, M., Cantero, J., Cao, Y., Capua, M., Cardarelli, R., Cardillo, F., Carducci, G., Carli, T., Carlino, G., Carlson, B. T., Carlson, E. M., Carminati, L., Carnesale, M., Carney, R. M.D., Caron, S., Carquin, E., Carrá, S., Carratta, G., Carter, J. W.S., Carter, T. M., Casadei, D., Casado, M. P., Casha, A. F., Castiglia, E. G., Castillo, F. L., Castillo Garcia, L., Castillo Gimenez, V., Castro, N. F., Catinaccio, A., Catmore, J. R., Cattai, A., Cavaliere, V., Cavalli, N., Cavasinni, V., Celebi, E., Celli, F., Cerny, K., Cerqueira, A. S., Cerri, A., Cerrito, L., Cerutti, F., Cervelli, A., Cetin, S. A., Chadi, Z., Chakraborty, D., Chala, M., Chan, J., Chan, W. S., Chan, W. Y., Chapman, J. D., Chargeishvili, B., Charlton, D. G., Charman, T. P., Chatterjee, M., Chau, C. C., Chekanov, S., Chekulaev, S. V., Chelkov, G. A., Chen, A., Chen, B., Chen, C., Chen, H., Chen, J., Chen, S., Chen, X., Chen, Y., Chen, Y. H., Cheng, C. L., Cheng, H. C., Cheplakov, A., Cheremushkina, E., Cherkaoui El Moursli, R., Cheu, E., Cheung, K., Chevalier, L., Chiarella, V., Chiarelli, G., Chiodini, G., Chisholm, A. S., Chitan, A., Chiu, I., Chiu, Y. H., Chizhov, M. V., Choi, K., Chomont, A. R., Chou, Y., Chow, Y. S., Christopher, L. D., Chu, M. C., Chu, X., Chudoba, J., Chwastowski, J. J., Cieri, D., Ciesla, K. M., Cindro, V., Cioară, I. A., Ciocio, A., Cirotto, F., Citron, Z. H., Citterio, M., Ciubotaru, D. A., Ciungu, B. M., Clark, A., Clark, P. J., Clawson, S. E., Clement, C., Clissa, L., Coadou, Y., Cobal, M., Coccaro, A., Cochran, J., Coelho Barrue, R. F., Coelho Lopes De Sa, R., Coelli, S., Cohen, H., Coimbra, A. E.C., Cole, B., Collot, J., Conde Muiño, P., Connell, S. H., Connelly, I. A., Conroy, E. I., Conventi, F., Cooke, H. G., Cooper-Sarkar, A. M., Cormier, F., Corpe, L. D., Corradi, M., Corrigan, E. E., Corriveau, F., Costa, M. J., Costanza, F., Costanzo, D., Cote, B. M., Cowan, G., Cowley, J. W., Crane, J., Cranmer, K., Creager, R. A., Crépé-Renaudin, S., Crescioli, F., Cristinziani, M., Cristoforetti, M., Croft, V., Crosetti, G., Cueto, A., Cuhadar Donszelmann, T., Cui, H., Cukierman, A. R., Cunningham, W. R., Czekierda, S., Czodrowski, P., Czurylo, M. M., Da Cunha Sargedas De Sousa, M. J., Da Fonseca Pinto, J. V., Da Via, C., Dabrowski, W., Dado, T., Dahbi, S., Dai, T., Dallapiccola, C., Dam, M., D'amen, G., D'Amico, V., Damp, J., Dandoy, J. R., Daneri, M. F., Danninger, M., Dao, V., Darbo, G., Darmora, S., Dattagupta, A., D'Auria, S., David, C., Davidek, T., Davis, D. R., Davis-Purcell, B., Dawson, I., De, K., De Asmundis, R., De Beurs, M., De Castro, S., De Groot, N., de Jong, P., De la Torre, H., De Maria, A., De Pedis, D., De Salvo, A., De Sanctis, U., De Santis, M., De Santo, A., De Vivie De Regie, J. B., Dedovich, D. V., Degens, J., Deiana, A. M., Del Peso, J., Delabat Diaz, Y., Deliot, F., Delitzsch, C. M., Della Pietra, M., Della Volpe, D., Dell'Acqua, A., Dell'Asta, L., Delmastro, M., Delsart, P. A., Demers, S., Demichev, M., Denisov, S. P., D'Eramo, L., Derendarz, D., Derkaoui, J. E., Derue, F., Dervan, P., Desch, K., Dette, K., Deutsch, C., Deviveiros, P. O., Di Bello, F. A., Di Ciaccio, A., Di Ciaccio, L., Di Donato, C., Di Girolamo, A., Di Gregorio, G., Di Luca, A., Di Micco, B., Di Nardo, R., Diaconu, C., Dias, F. A., Dias Do Vale, T., Diaz, M. A., Diaz Capriles, F. G., Dickinson, J., Didenko, M., Diehl, E. B., Dietrich, J., Díez Cornell, S., Diez Pardos, C., Dimitrievska, A., Ding, W., Dingfelder, J., Dittmeier, S. J., Dittus, F., Djama, F., Djobava, T., Djuvsland, J. I., Do Vale, M. A.B., Dodsworth, D., Doglioni, C., Dolejsi, J., Dolezal, Z., Donadelli, M., Dong, B., Donini, J., D'onofrio, A., D'Onofrio, M., Dopke, J., Doria, A., Dova, M. T., Doyle, A. T., Drechsler, E., Dreyer, E., Dreyer, T., Drobac, A. S., Du, D., du Pree, T. A., Dubinin, F., Dubovsky, M., Dubreuil, A., Duchovni, E., Duckeck, G., Ducu, O. A., Duda, D., Dudarev, A., D'uffizi, M., Duflot, L., Dührssen, M., Dülsen, C., Dumitriu, A. E., Dunford, M., Dungs, S., Duperrin, A., Duran Yildiz, H., Düren, M., Durglishvili, A., Dutta, B., Duvnjak, D., Dyckes, G. I., Dyndal, M., Dysch, S., Dziedzic, B. S., Eckerova, B., Eggleston, M. G., Egidio Purcino De Souza, E., Ehrke, L. F., Eifert, T., Eigen, G., Einsweiler, K., Ekelof, T., El Ghazali, Y., El Jarrari, H., El Moussaouy, A., Ellajosyula, V., Ellert, M., Ellinghaus, F., Elliot, A. A., Ellis, N., Elmsheuser, J., Elsing, M., Emeliyanov, D., Emerman, A., Enari, Y., Erdmann, J., Ereditato, A., Erland, P. A., Errenst, M., Escalier, M., Escobar, C., Estrada Pastor, O., Etzion, E., Evans, G., Evans, H., Evans, M. O., Ezhilov, A., Fabbri, F., Fabbri, L., Fabiani, V., Facini, G., Fakhrutdinov, R. M., Falciano, S., Falke, P. J., Falke, S., Faltova, J., Fan, Y., Fang, Y., Fanourakis, G., Fanti, M., Faraj, M., Farbin, A., Farilla, A., Farina, E. M., Farooque, T., Farrington, S. M., Farthouat, P., Fassi, F., Fassouliotis, D., Faucci Giannelli, M., Fawcett, W. J., Fayard, L., Fedin, O. L., Feickert, M., Feligioni, L., Fell, A., Feng, C., Feng, M., Fenton, M. J., Fenyuk, A. B., Ferguson, S. W., Ferrando, J., Ferrari, A., Ferrari, P., Ferrari, R., Ferrere, D., Ferretti, C., Fiedler, F., Filipčič, A., Filthaut, F., Fiolhais, M. C.N., Fiorini, L., Fischer, F., Fisher, W. C., Fitschen, T., Fleck, I., Fleischmann, P., Flick, T., Flierl, B. M., Flores, L., Flores Castillo, L. R., Follega, F. M., Fomin, N., Foo, J. H., Forcolin, G. T., Forland, B. C., Formica, A., Förster, F. A., Forti, A. C., Fortin, E., Foti, M. G., Fournier, D., Fox, H., Francavilla, P., Francescato, S., Franchini, M., Franchino, S., Francis, D., Franco, L., Franconi, L., Franklin, M., Frattari, G., Freegard, A. C., Freeman, P. M., Freund, B., Freund, W. S., Freundlich, E. M., Froidevaux, D., Frost, J. A., Fu, Y., Fujimoto, M., Fullana Torregrosa, E., Fusayasu, T., Fuster, J., Gabrielli, A., Gadow, P., Gagliardi, G., Gagnon, L. G., Gallardo, G. E., Gallas, E. J., Gallop, B. J., Gamboa Goni, R., Gan, K. K., Ganguly, S., Gao, J., Gao, Y. S., Garay Walls, F. M., García, C., García Navarro, J. E., García Pascual, J. A., Garcia-Sciveres, M., Gardner, R. W., Garg, D., Gargiulo, S., Garner, C. A., Garonne, V., Gasiorowski, S. J., Gaspar, P., Gaudio, G., Gauzzi, P., Gavrilenko, I. L., Gavrilyuk, A., Gay, C., Gaycken, G., Gazis, E. N., Geanta, A. A., Gee, C. M., Gee, C. N.P., Geisen, J., Geisen, M., Gemme, C., Genest, M. H., Gentile, S., George, S., Geralis, T., Gerlach, L. O., Gessinger-Befurt, P., Ghasemi Bostanabad, M., Ghneimat, M., Ghosh, A., Giacobbe, B., Giagu, S., Giangiacomi, N., Giannetti, P., Giannini, A., Gibson, S. M., Gignac, M., Gil, D. T., Gilbert, B. J., Gillberg, D., Gilles, G., Gillwald, N. 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Abstract: A search with minimal model dependence for physics beyond the Standard Model in events featuring three or four charged leptons (3ℓ and 4ℓ, ) is presented. The analysis aims to be sensitive to a wide range of potential new-physics theories simultaneously. This analysis uses data from pp collisions delivered by the Large Hadron Collider at a centre-of-mass energy of TeV and recorded with the ATLAS detector, corresponding to the full Run 2 dataset of 139 fb−1. The 3ℓ and 4ℓ phase space is divided into 22 event categories according to the number of leptons in the event, the missing transverse momentum, the invariant mass of the leptons, and the presence of leptons originating from a Z-boson candidate. These event categories are analysed independently for the presence of deviations from the Standard Model. No statistically significant deviations from the Standard Model predictions are observed. Upper limits for all signal regions are reported in terms of the visible cross-section.
Published: 2022

23. Search for new phenomena in three- or four-lepton events in pp collisions at √s=13 TeV with the ATLAS detector

Author: Aad, G., Abbott, B., Abbott, D. C., Abed Abud, A., Abeling, K., Abhayasinghe, D. K., Abidi, S. H., AbouZeid, O. S., Abramowicz, H., Abreu, H., Abulaiti, Y., Abusleme Hoffman, A. C., Acharya, B. S., Achkar, B., Adam, L., Adam Bourdarios, C., Adamczyk, L., Adamek, L., Adelman, J., Adiguzel, A., Adorni, S., Adye, T., Affolder, A. A., Afik, Y., Agapopoulou, C., Agaras, M. N., Agarwala, J., Aggarwal, A., Agheorghiesei, C., Aguilar-Saavedra, J. A., Ahmad, A., Ahmadov, F., Ahmed, W. S., Ai, X., Aielli, G., Akatsuka, S., Akbiyik, M., Åkesson, T. P.A., Akimov, A. V., Al Khoury, K., Alberghi, G. L., Albert, J., Alconada Verzini, M. J., Alderweireldt, S., Aleksa, M., Aleksandrov, I. N., Alexa, C., Alexopoulos, T., Alfonsi, A., Alfonsi, F., Alhroob, M., Ali, B., Ali, S., Aliev, M., Alimonti, G., Allaire, C., Allbrooke, B. M.M., Allport, P. P., Aloisio, A., Alonso, F., Alpigiani, C., Alunno Camelia, E., Alvarez Estevez, M., Alviggi, M. G., Amaral Coutinho, Y., Ambler, A., Ambroz, L., Amelung, C., Amidei, D., Amor Dos Santos, S. P., Amoroso, S., Amrouche, C. S., Anastopoulos, C., Andari, N., Andeen, T., Anders, J. K., Andrean, S. Y., Andreazza, A., Andrei, V., Angelidakis, S., Angerami, A., Anisenkov, A. V., Annovi, A., Antel, C., Anthony, M. T., Antipov, E., Antonelli, M., Antrim, D. J.A., Anulli, F., Aoki, M., Aparisi Pozo, J. A., Aparo, M. A., Aperio Bella, L., Aranzabal, N., Araujo Ferraz, V., Arcangeletti, C., Arce, A. T.H., Arena, E., Arguin, J. F., Argyropoulos, S., Arling, J. H., Armbruster, A. J., Armstrong, A., Arnaez, O., Arnold, H., Arrubarrena Tame, Z. P., Artoni, G., Asada, H., Asai, K., Asai, S., Asbah, N. A., Asimakopoulou, E. M., Asquith, L., Assahsah, J., Assamagan, K., Astalos, R., Atkin, R. J., Atkinson, M., Atlay, N. B., Atmani, H., Atmasiddha, P. A., Augsten, K., Auricchio, S., Austrup, V. A., Avolio, G., Ayoub, M. K., Azuelos, G., Babal, D., Bachacou, H., Bachas, K., Backman, F., Badea, A., Bagnaia, P., Bahrasemani, H., Bailey, A. J., Bailey, V. R., Baines, J. T., Bakalis, C., Baker, O. K., Bakker, P. J., Bakos, E., Bakshi Gupta, D., Balaji, S., Balasubramanian, R., Baldin, E. M., Balek, P., Ballabene, E., Balli, F., Balunas, W. K., Balz, J., Banas, E., Bandieramonte, M., Bandyopadhyay, A., Barak, L., Barberio, E. L., Barberis, D., Barbero, M., Barbour, G., Barends, K. N., Barillari, T., Barisits, M. S., Barkeloo, J., Barklow, T., Barnett, B. M., Barnett, R. M., Baroncelli, A., Barone, G., Barr, A. J., Barranco Navarro, L., Barreiro, F., Barreiro Guimarães da Costa, J., Barron, U., Barsov, S., Bartels, F., Bartoldus, R., Bartolini, G., Barton, A. E., Bartos, P., Basalaev, A., Basan, A., Bashta, I., Bassalat, A., Basso, M. J., Basson, C. R., Bates, R. L., Batlamous, S., Batley, J. R., Batool, B., Battaglia, M., Bauce, M., Bauer, F., Bauer, P., Bawa, H. S., Bayirli, A., Beacham, J. B., Beau, T., Beauchemin, P. H., Becherer, F., Bechtle, P., Beck, H. P., Becker, K., Becot, C., Beddall, A. J., Bednyakov, V. A., Bee, C. P., Beermann, T. A., Begalli, M., Begel, M., Behera, A., Behr, J. K., Beirao Da Cruz E Silva, C., Beirer, J. F., Beisiegel, F., Belfkir, M., Bella, G., Bellagamba, L., Bellerive, A., Bellos, P., Beloborodov, K., Belotskiy, K., Belyaev, N. L., Benchekroun, D., Benhammou, Y., Benjamin, D. P., Benoit, M., Bensinger, J. R., Bentvelsen, S., Beresford, L., Beretta, M., Berge, D., Bergeaas Kuutmann, E., Berger, N., Bergmann, B., Bergsten, L. J., Beringer, J., Berlendis, S., Bernardi, G., Bernius, C., Bernlochner, F. U., Berry, T., Berta, P., Berthold, A., Bertram, I. A., Bessidskaia Bylund, O., Bethke, S., Betti, A., Bevan, A. J., Bhatta, S., Bhattacharya, D. S., Bhattarai, P., Bhopatkar, V. S., Bi, R., Bianchi, R. M., Biebel, O., Bielski, R., Biesuz, N. V., Biglietti, M., Billoud, T. R.V., Bindi, M., Bingul, A., Bini, C., Biondi, S., Birch-sykes, C. 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H., Tnourji, A., Todome, K., Todorova-Nova, S., Todt, S., Togawa, M., Tojo, J., Tokár, S., Tokushuku, K., Tolley, E., Tombs, R., Tomoto, M., Tompkins, L., Tornambe, P., Torrence, E., Torres, H., Torró Pastor, E., Toscani, M., Tosciri, C., Toth, J., Tovey, D. R., Traeet, A., Treado, C. J., Trefzger, T., Tricoli, A., Trigger, I. M., Trincaz-Duvoid, S., Trischuk, D. A., Trischuk, W., Trocmé, B., Trofymov, A., Troncon, C., Trovato, F., Truong, L., Trzebinski, M., Trzupek, A., Tsai, F., Tsiamis, A., Tsiareshka, P. V., Tsirigotis, A., Tsiskaridze, V., Tskhadadze, E. G., Tsopoulou, M., Tsukerman, I. I., Tsulaia, V., Tsuno, S., Tsur, O., Tsybychev, D., Tu, Y., Tudorache, A., Tudorache, V., Tuna, A. N., Turchikhin, S., Turgeman, D., Turk Cakir, I., Turner, R. J., Turra, R., Tuts, P. M., Tzamarias, S., Tzanis, P., Tzovara, E., Uchida, K., Ukegawa, F., Unal, G., Unal, M., Undrus, A., Unel, G., Ungaro, F. C., Uno, K., Urban, J., Urquijo, P., Usai, G., Ushioda, R., Uysal, Z., Vacek, V., Vachon, B., Vadla, K. O.H., Vafeiadis, T., Valderanis, C., Valdes Santurio, E., Valente, M., Valentinetti, S., Valero, A., Valéry, L., Vallance, R. A., Vallier, A., Valls Ferrer, J. A., Van Daalen, T. R., Van Gemmeren, P., Van Stroud, S., Van Vulpen, I., Vanadia, M., Vandelli, W., Vandenbroucke, M., Vandewall, E. R., Vannicola, D., Vannoli, L., Vari, R., Varnes, E. W., Varni, C., Varol, T., Varouchas, D., Varvell, K. E., Vasile, M. E., Vaslin, L., Vasquez, G. A., Vazeille, F., Vazquez Furelos, D., Vazquez Schroeder, T., Veatch, J., Vecchio, V., Veen, M. J., Veliscek, I., Veloce, L. M., Veloso, F., Veneziano, S., Ventura, A., Verbytskyi, A., Verducci, M., Vergis, C., Verissimo De Araujo, M., Verkerke, W., Vermeulen, A. T., Vermeulen, J. C., Vernieri, C., Verschuuren, P. J., Vesterbacka, M. L., Vetterli, M. C., Viaux Maira, N., Vickey, T., Vickey Boeriu, O. E., Viehhauser, G. H.A., Vigani, L., Villa, M., Villaplana Perez, M., Villhauer, E. M., Vilucchi, E., Vincter, M. G., Virdee, G. S., Vishwakarma, A., Vittori, C., Vivarelli, I., Vladimirov, V., Voevodina, E., Vogel, M., Vokac, P., Von Ahnen, J., von Buddenbrock, S. E., Von Toerne, E., Vorobel, V., Vorobev, K., Vos, M., Vossebeld, J. H., Vozak, M., Vranjes, N., Vranjes Milosavljevic, M., Vrba, V., Vreeswijk, M., Vu, N. K., Vuillermet, R., Vukotic, I., Wada, S., Wagner, C., Wagner, P., Wagner, W., Wahdan, S., Wahlberg, H., Wakasa, R., Wakida, M., Walbrecht, V. M., Walder, J., Walker, R., Walker, S. D., Walkowiak, W., Wang, A. Z., Wang, C., Wang, H., Wang, J., Wang, P., Wang, R. J., Wang, S. M., Wang, T., Wang, W. T., Wang, X., Wang, Y., Wang, Z., Wanotayaroj, C., Warburton, A., Ward, C. P., Ward, R. J., Warrack, N., Watson, A. T., Watson, M. F., Watts, G., Waugh, B. M., Webb, A. F., Weber, C., Weber, M. S., Weber, S. A., Weber, S. M., Wei, C., Wei, Y., Weidberg, A. R., Weingarten, J., Weirich, M., Weiser, C., Wenaus, T., Wendland, B., Wengler, T., Wenig, S., Wermes, N., Wessels, M., Whalen, K., Wharton, A. M., White, A. S., White, M. J., Whiteson, D., Wiedenmann, W., Wiel, C., Wielers, M., Wieseotte, N., Wiglesworth, C., Wiik-Fuchs, L. A.M., Wilbern, D. J., Wilkens, H. G., Wilkins, L. J., Williams, D. M., Williams, H. H., Williams, S., Willocq, S., Windischhofer, P. J., Wingerter-Seez, I., Winklmeier, F., Winter, B. T., Wittgen, M., Wobisch, M., Wolf, A., Wölker, R., Wollrath, J., Wolter, M. W., Wolters, H., Wong, V. W.S., Wongel, A. F., Worm, S. D., Wosiek, B. K., Woźniak, K. W., Wraight, K., Wu, J., Wu, S. L., Wu, X., Wu, Y., Wu, Z., Wuerzinger, J., Wyatt, T. R., Wynne, B. M., Xella, S., Xiang, J., Xiao, X., Xie, X., Xiotidis, I., Xu, D., Xu, H., Xu, L., Xu, R., Xu, T., Xu, W., Xu, Y., Xu, Z., Yabsley, B., Yacoob, S., Yamaguchi, N., Yamaguchi, Y., Yamatani, M., Yamauchi, H., Yamazaki, T., Yamazaki, Y., Yan, J., Yan, Z., Yang, H. T., Yang, S., Yang, T., Yang, X., Yang, Y., Yang, Z., Yao, W. M., Yap, Y. C., Ye, H., Ye, J., Ye, S., Yeletskikh, I., Yexley, M. R., Yin, P., Yorita, K., Yoshihara, K., Young, C. J.S., Yuan, R., Yue, X., Zaazoua, M., Zabinski, B., Zacharis, G., Zaffaroni, E., Zaitsev, A. M., Zakareishvili, T., Zakharchuk, N., Zambito, S., Zanzi, D., Zeißner, S. V., Zeitnitz, C., Zemaityte, G., Zeng, J. C., Zenin, O., Ženiš, T., Zenz, S., Zerradi, S., Zerwas, D., Zgubič, M., Zhang, B., Zhang, D. F., Zhang, G., Zhang, J., Zhang, K., Zhang, L., Zhang, M., Zhang, R., Zhang, S., Zhang, X., Zhang, Z., Zhao, P., Zhao, Y., Zhao, Z., Zhemchugov, A., Zheng, Z., Zhong, D., Zhou, B., Zhou, C., Zhou, H., Zhou, N., Zhou, Y., Zhu, C. G., Zhu, C., Zhu, H. L., Zhu, J., Zhu, Y., Zhuang, X., Zhukov, K., Zhulanov, V., Zieminska, D., Zimine, N. I., Zimmermann, S., Ziolkowski, M., Živković, L., Zoccoli, A., Zoch, K., Zorbas, T. G., Zormpa, O., Zou, W., and Zwalinski, L.
Abstract: A search with minimal model dependence for physics beyond the Standard Model in events featuring three or four charged leptons (3ℓ and 4ℓ, ) is presented. The analysis aims to be sensitive to a wide range of potential new-physics theories simultaneously. This analysis uses data from pp collisions delivered by the Large Hadron Collider at a centre-of-mass energy of TeV and recorded with the ATLAS detector, corresponding to the full Run 2 dataset of 139 fb−1. The 3ℓ and 4ℓ phase space is divided into 22 event categories according to the number of leptons in the event, the missing transverse momentum, the invariant mass of the leptons, and the presence of leptons originating from a Z-boson candidate. These event categories are analysed independently for the presence of deviations from the Standard Model. No statistically significant deviations from the Standard Model predictions are observed. Upper limits for all signal regions are reported in terms of the visible cross-section.
Published: 2022

24. The development of Future Health Today: piloting a new platform for identification and management of chronic disease in general practice

Author: Hunter, B, Alexander, K, Biezen, R, Hallinan, CM, Wood, A, Nelson, C, Manski-Nankervis, J-A, Hunter, B, Alexander, K, Biezen, R, Hallinan, CM, Wood, A, Nelson, C, and Manski-Nankervis, J-A
Abstract: Chronic disease identification and management is a significant issue in Australia, with general practice being the primary contact point for those at risk of, or living with, chronic disease. However, there is a well-described gap between guideline recommendations for chronic disease management and translation in the general practice setting. In 2018, a group of researchers, clinicians and software developers collaborated to develop a tool to support the identification and management of chronic disease in general practice, with the aim to create a platform that met the needs of general practice. The co-design process drew together core principles and expectations for the establishment of a technological platform, called Future Health Today (FHT), which would sit alongside the electronic medical record (EMR) management system within general practice. FHT used algorithms applied to EMR data to identify patients with, or at risk of, chronic disease and requiring review. Using chronic kidney disease as a clinical focus, the FHT prototype was piloted in a large, metropolitan general practice, and a large regional general practice. Based on user feedback, the prototype was further developed and improved. This paper provides a report on the key features and functionalities that participants identified and implemented in practice.
Published: 2022

25. Social ecological influences on treatment decision-making in men diagnosed with low risk, localised prostate cancer

Author: McIntosh, M, Opozda, MJ, Short, CE, Galvao, DA, Tutino, R, Diefenbach, M, Ehdaie, B, Nelson, C, McIntosh, M, Opozda, MJ, Short, CE, Galvao, DA, Tutino, R, Diefenbach, M, Ehdaie, B, and Nelson, C
Abstract: OBJECTIVE: Individuals diagnosed with low risk, localised prostate cancer (PCa) face a difficult decision between active surveillance (AS) and definitive treatment. We aimed to explore perceived influences on treatment decision-making from the patient and partner's perspectives. METHODS: Patients (and partners) who met AS criteria and had chosen their treatment were recruited. Semi-structured individual interviews were conducted via telephone to explore experiences of diagnosis, impact on patient lifestyle, experiences with physicians, treatment preferences/choice, treatment information understanding and needs, and overall decision-making process. Interviews were audio recorded, transcribed verbatim, and analysed using Reflexive Thematic Analysis. RESULTS: Twenty-four male patients (18 chose AS) and 12 female partners participated. Five themes relating to social-ecological influences on treatment choice were identified: (1) partner support and direct influence on patient treatment choice, (2) patient and partner vicarious experiences may influence treatment decisions, (3) the influence of the patient's life circumstances, (4) disclosing to wider social networks: friends, family, and co-workers, and (5) the importance of a good relationship and experience with physicians. Additionally, two themes were identified relating to information patients and partners received about the treatment options during their decision-making process. CONCLUSIONS: A range of individual and social influences on treatment decision-making were reported. Physicians providing treatment recommendations should consider and discuss the patient and partner's existing beliefs and treatment preferences and encourage shared decision-making. Further research on treatment decision-making of partnered and non-partnered PCa patients is required. We recommend research considers social ecological factors across the personal, interpersonal, community, and policy levels.
Published: 2022

26. Investigating datasets with high IRIS burst prevalence

Author: Nelson, C. J., Kleint, L., Nelson, C. J., and Kleint, L.
Abstract: Approximately 0.01 % of all Si IV 1394 A spectra sampled in 2013 and 2014 by the Interface Region Imaging Spectrograph (IRIS) have IRIS burst profiles. However, these events are not evenly distributed across datasets with 19.31 % of these spectra being identified in only six rasters. Here, we investigate five of these six datasets, to understand why they contain so many IRIS burst profiles. This research will help guide future targeted analyses of IRIS bursts. We analyse five datasets sampled by the IRIS satellite, studying both Si IV 1394 A spectra and 1400 A filter slit-jaw imager (SJI) data. IRIS burst profiles are identified through the use of an automated algorithm. Additionally, we study co-spatial line-of-sight photospheric magnetic field maps sampled by the Solar Dynamics Observatory's Helioseismic and Magnetic Imager (SDO/HMI) instrument. The majority of identified IRIS burst profiles (12401 out of 13904) found in the five datasets analysed here were localised to seven small regions in the time-distance domain (temporal durations of <4 hours and spatial lengths of <12" along the slit). The SJI data co-spatial to these regions contained long-lived or repetitive compact brightenings, matching the defined properties of UV bursts, which remained close to the IRIS slit throughout their evolutions. The IRIS burst profiles were not limited to the brightest pixels in the fields of view (FOVs) nor did they comprise the majority of bright (>500 DN/s) pixels. These IRIS burst profiles occurred co-spatial to evolving (e.g. cancelling) opposite polarity magnetic fields where magnetic reconnection is thought to be possible. More than 10 % of the IRIS burst profiles identified during the entirety of 2013 and 2014 are contained in just seven small regions in the time-distance domain where long-lived (lifetimes >10 minutes) or repetitive UV bursts occurred along the axis of the IRIS slit., Comment: 12 pages, 9 figures, accepted to A&A
Published: 2022
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27. Pre-emergence Signatures Of Horizontal Divergent Flows In Solar Active Regions

Author: Rees-Crockford, T., Nelson, C. J., Mathioudakis, M., Rees-Crockford, T., Nelson, C. J., and Mathioudakis, M.
Abstract: Solar active regions (ARs) play a fundamental role in driving many of the geo-effective eruptions which propagate into the Solar System. However, we are still unable to consistently predict where and when ARs will occur across the solar disk by identifying pre-emergence signatures in observables such as the Doppler velocity (without using Helioseismic methods). Here we aim to determine the earliest time at which pre-emergence signatures, specifically the Horizontal Divergent Flow (HDF), can be confidently detected using data from the Solar Dynamics Observatory's Helioseismic and Magnetic Imager (SDO/HMI). Initially, we follow previous studies using the thresholding method, which searches for significant increases in the number of pixels that display a specific line-of-sight velocity. We expand this method to more velocity windows and conduct a basic parameter study investigating the effect of cadence on the inferred results. Our findings agree with previous studies with $37.5$% of ARs displaying a HDF, with average lead times between the HDF and flux emergence of $58$ minutes. We present a new potential signature of flux emergence which manifests as cadence-independent transient disruptions to the amplitudes of multiple velocity windows and recover potential pre-emergence signatures for 10 of the 16 ARs studied, with lead times of 60-156 minutes. Several effects can influence both the estimated times of both HDF and flux emergence suggesting that one may need to combine Doppler and magnetic field data to get a reliable indicator of continued flux emergence., Comment: 19 Pages, 8 Figures, 2 Tables, 2 Supplemental Figure Sets
Published: 2022
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28. IRIS burst properties in active regions

Author: Nelson, C. J., Kleint, L., Nelson, C. J., and Kleint, L.
Abstract: Interface Region Imaging Spectrograph (IRIS) bursts are localised features thought to be driven by magnetic reconnection. Although these events are well-studied, it remains unknown whether their properties vary as their host active regions (ARs) evolve. Here, we aim to understand whether the measurable properties of IRIS bursts are consistent during the evolution of their host ARs. We study 42 dense 400-step rasters sampled by IRIS. These rasters each covered one of seven ARs, with each AR being sampled at least four times over a minimum of 48 hours. An automated detection algorithm is used to identify IRIS burst profiles. Data from the Solar Dynamics Observatory's Helioseismic and Magnetic Imager are also used to provide context about the co-spatial line-of-sight magnetic field. Of the rasters studied, 36 were found to contain IRIS burst profiles. Five ARs (11850, 11909, 11916, 12104, and 12139) contained IRIS burst profiles in each raster that sampled them whilst one AR (11871) was found to contain no such spectra at any time. A total of 4019 IRIS burst profiles belonging to 752 connected objects, which we define as parent IRIS bursts, were identified. IRIS burst profiles were only detected within compact regions in each raster, with these regions appearing to increase in size as the host ARs aged. No systematic changes in the frequency of IRIS burst profiles or the spectral characteristic of IRIS burst profiles through time were found for these ARs. Finally, 93 % of parent IRIS bursts with areas between 1 arcsec^2 and 4 arcsec^2 occurred co-spatial to bi-poles in the photosphere. Overall, IRIS bursts have remarkably consistent spectral and spatial properties throughout the evolution of ARs. These events predominantly form within the cores of larger and more complex ARs, with the regions containing these events appearing to increase in size as the host region itself evolves., Comment: 12 pages, 7 figures, accepted by A&A
Published: 2022
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29. The European Solar Telescope

Author: Noda, C. Quintero, Schlichenmaier, R., Rubio, L. R. Bellot, Löfdahl, M. G., Khomenko, E., Jurcak, J., Leenaarts, J., Kuckein, C., Manrique, S. J. González, Gunar, S., Nelson, C. J., Rodríguez, J. de la Cruz, Tziotziou, K., Tsiropoula, G., Aulanier, G., Collados, M., team, the EST, Noda, C. Quintero, Schlichenmaier, R., Rubio, L. R. Bellot, Löfdahl, M. G., Khomenko, E., Jurcak, J., Leenaarts, J., Kuckein, C., Manrique, S. J. González, Gunar, S., Nelson, C. J., Rodríguez, J. de la Cruz, Tziotziou, K., Tsiropoula, G., Aulanier, G., Collados, M., and team, the EST
Abstract: The European Solar Telescope (EST) is a project aimed at studying the magnetic connectivity of the solar atmosphere, from the deep photosphere to the upper chromosphere. Its design combines the knowledge and expertise gathered by the European solar physics community during the construction and operation of state-of-the-art solar telescopes operating in visible and near-infrared wavelengths: the Swedish 1m Solar Telescope (SST), the German Vacuum Tower Telescope (VTT) and GREGOR, the French T\'elescope H\'eliographique pour l'\'Etude du Magn\'etisme et des Instabilit\'es Solaires (TH\'EMIS), and the Dutch Open Telescope (DOT). With its 4.2 m primary mirror and an open configuration, EST will become the most powerful European ground-based facility to study the Sun in the coming decades in the visible and near-infrared bands. EST uses the most innovative technological advances: the first adaptive secondary mirror ever used in a solar telescope, a complex multi-conjugate adaptive optics with deformable mirrors that form part of the optical design in a natural way, a polarimetrically compensated telescope design that eliminates the complex temporal variation and wavelength dependence of the telescope Mueller matrix, and an instrument suite containing several (etalon-based) tunable imaging spectropolarimeters and several integral field unit spectropolarimeters. This publication summarises some fundamental science questions that can be addressed with the telescope, together with a complete description of its major subsystems., Comment: 38 pages, 24 figures
Published: 2022
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30. Recognizing megatsunamis in Mediterranean deep sea sediments based on the massive deposits of the 365 CE Crete event

Author: Consiglio Nazionale delle Ricerche, Polonia, Alina, Nelson, C. Hans, Vaiani, S. C., Colizza, E., Gasparotto, G., Giorgetti, G., Bonetti, C., Gasperini, Luca, Consiglio Nazionale delle Ricerche, Polonia, Alina, Nelson, C. Hans, Vaiani, S. C., Colizza, E., Gasparotto, G., Giorgetti, G., Bonetti, C., and Gasperini, Luca
Abstract: The Mediterranean Sea hosts two subduction systems along the convergent Africa-Eurasia plate boundary that have produced strong ground shaking and generated tsunamis. Based on historical descriptions and sedimentary records, one of these events, in 365 CE, impacted a broad geographical area, including tsunami evidence for distances of 700–800 km from the source event, qualifying it as a ‘megatsunami’. Understanding how megatsunamis are produced, and where they are more likely, requires a better understanding of the different secondary processes linked to these events such as massive slope failures, multiple turbidity current generation, and basin seiching. Our sedimentary records from an extensive collection of cores located in distal and disconnected basins, identify turbidites which are analyzed using granulometry, elemental (XRF), micropaleontological, and geochemical data in order to reconstruct their coastal or marine source. The results show that the 365 CE basin floor sediments are a mixture of inner shelf and slope materials. The tsunami wave produced multiple far-field slope failures that resulted in stacked basal turbidites. It also caused transport of continent-derived organic carbon and deposition over basal turbidites and into isolated basins of the deep ocean. The composition of sediment in isolated basins suggests their deposition by large-scale sheet like flows similar to what has been caused by the Tohoku earthquake associated tsunamis. This is significant for rectifying and resolving where risk is greatest and how cross-basin tsunamis are generated. Based on these results, estimates of the underlying deposits from the same locations were interpreted as possible older megatsunamis.
Published: 2022

31. Investigation of light ion fusion reactions with plasma discharges (II)

Author: Schenkel, Thomas, Schenkel, Thomas, Persaud, Arun, Wang, H, Seidl, P, MacFayden, R, Nelson, C, Waldron, Lawrence, Vay, Jean-Luc, Ji, Qing, Deblonde, Gauthier, Wen, B, Chiang, Yet-Ming, MacLeod, Ben P, Schenkel, Thomas, Schenkel, Thomas, Persaud, Arun, Wang, H, Seidl, P, MacFayden, R, Nelson, C, Waldron, Lawrence, Vay, Jean-Luc, Ji, Qing, Deblonde, Gauthier, Wen, B, Chiang, Yet-Ming, and MacLeod, Ben P
Abstract: The scaling of reaction yields in light ion fusion to low reaction energies is important for our understanding of stellar fuel chains and the development of future energy technologies. Experiments become progressively more challenging at lower reaction energies due to the exponential drop of fusion cross sections below the Coulomb barrier. We report on experiments where deuterium-deuterium (D-D) fusion reactions are studied in a pulsed plasma in the glow discharge regime using a benchtop apparatus. We model plasma conditions using particle-in-cell codes. Advantages of this approach are relatively high peak ion currents and current densities (0.1 to several A/cm2) that can be applied to metal wire cathodes for several days. We detect neutrons from D-D reactions with scintillator-based detectors. For palladium targets, we find neutron yields as a function of cathode voltage that are over 100 times higher than yields expected for bare nuclei fusion at ion energies below 2 keV (center of mass frame). A possible explanation is a correction to the ion energy due to an electron screening potential of 1000±250 eV, which increases the probability for tunneling through the repulsive Coulomb barrier. Our compact, robust setup enables parametric studies of this effect at relatively low reaction energies.
Published: 2021

32. The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype

Author: Thomas, P.B., Jeffery, P., Gahete, M.D., Whiteside, E., Walpole, C., Maugham, M., Jovanovic, L., Gunter, J., Williams, E., Nelson, C., Herington, A., Luque, R.M., Veedu, R., Chopin, L.K., Seim, I., Thomas, P.B., Jeffery, P., Gahete, M.D., Whiteside, E., Walpole, C., Maugham, M., Jovanovic, L., Gunter, J., Williams, E., Nelson, C., Herington, A., Luque, R.M., Veedu, R., Chopin, L.K., and Seim, I.
Abstract: It is now appreciated that long non-coding RNAs (lncRNAs) are important players in orchestrating cancer progression. In this study we characterized GHSROS, a human lncRNA gene on the opposite DNA strand (antisense) to the ghrelin receptor gene, in prostate cancer. The lncRNA was upregulated by prostate tumors from different clinical datasets. Transcriptome data revealed that GHSROS alters the expression of cancer-associated genes. Functional analyses in vitro showed that GHSROS mediates tumor growth, migration and survival, and resistance to the cytotoxic drug docetaxel. Increased cellular proliferation of GHSROS-overexpressing PC3, DU145, and LNCaP prostate cancer cell lines in vitro was recapitulated in a subcutaneous xenograft model. Conversely, in vitro antisense oligonucleotide inhibition of the lncRNA reciprocally regulated cell growth and migration, and gene expression. Notably, GHSROS modulates the expression of PPP2R2C, the loss of which may drive androgen receptor pathway-independent prostate tumor progression in a subset of prostate cancers. Collectively, our findings suggest that GHSROS can reprogram prostate cancer cells toward a more aggressive phenotype and that this lncRNA may represent a potential therapeutic target.
Published: 2021

33. Targeted therapy of TERT-rearranged neuroblastoma with BET bromodomain inhibitor and proteasome inhibitor combination therapy

Author: Chen, J ; https://orcid.org/0000-0002-6774-0199, Nelson, C, Wong, M ; https://orcid.org/0000-0002-0324-8664, Tee, AE, Liu, PY ; https://orcid.org/0000-0001-9237-5990, La, T, Fletcher, JI ; https://orcid.org/0000-0003-2949-9469, Kamili, A ; https://orcid.org/0000-0002-4864-1195, Mayoh, C ; https://orcid.org/0000-0002-6398-3046, Bartenhagen, C, Trahair, TN ; https://orcid.org/0000-0002-3295-228X, Xu, N, Jayatilleke, N ; https://orcid.org/0000-0003-4086-0622, Wong, M, Peng, H, Atmadibrata, B, Cheung, BB ; https://orcid.org/0000-0001-8784-860X, Lan, Q, Bryan, TM, Mestdagh, P, Vandesompele, J, Combaret, V, Boeva, V, Wang, JY ; https://orcid.org/0000-0002-1325-7943, Janoueix-Lerosey, I, Cowley, MJ ; https://orcid.org/0000-0002-9519-5714, MacKenzie, KL, Dolnikov, A, Li, J, Polly, P ; https://orcid.org/0000-0001-7250-5217, Marshall, GM, Reddel, RR, Norris, MD ; https://orcid.org/0000-0002-0632-4589, Haber, M ; https://orcid.org/0000-0003-2036-8817, Fischer, M, Zhang, XD, Pickett, HA, Liu, T ; https://orcid.org/0000-0001-6244-7316, Chen, J ; https://orcid.org/0000-0002-6774-0199, Nelson, C, Wong, M ; https://orcid.org/0000-0002-0324-8664, Tee, AE, Liu, PY ; https://orcid.org/0000-0001-9237-5990, La, T, Fletcher, JI ; https://orcid.org/0000-0003-2949-9469, Kamili, A ; https://orcid.org/0000-0002-4864-1195, Mayoh, C ; https://orcid.org/0000-0002-6398-3046, Bartenhagen, C, Trahair, TN ; https://orcid.org/0000-0002-3295-228X, Xu, N, Jayatilleke, N ; https://orcid.org/0000-0003-4086-0622, Wong, M, Peng, H, Atmadibrata, B, Cheung, BB ; https://orcid.org/0000-0001-8784-860X, Lan, Q, Bryan, TM, Mestdagh, P, Vandesompele, J, Combaret, V, Boeva, V, Wang, JY ; https://orcid.org/0000-0002-1325-7943, Janoueix-Lerosey, I, Cowley, MJ ; https://orcid.org/0000-0002-9519-5714, MacKenzie, KL, Dolnikov, A, Li, J, Polly, P ; https://orcid.org/0000-0001-7250-5217, Marshall, GM, Reddel, RR, Norris, MD ; https://orcid.org/0000-0002-0632-4589, Haber, M ; https://orcid.org/0000-0003-2036-8817, Fischer, M, Zhang, XD, Pickett, HA, and Liu, T ; https://orcid.org/0000-0001-6244-7316
Abstract: Purpose: TERT gene rearrangement with transcriptional superenhancers leads to TERT overexpression and neuroblastoma. No targeted therapy is available for clinical trials in patients with TERT-rearranged neuroblastoma. Experimental Design: Anticancer agents exerting the best synergistic anticancer effects with BET bromodomain inhibitors were identiﬁed by screening an FDA-approved oncology drug library. The synergistic effects of the BET bromodomain inhibitor OTX015 and the proteasome inhibitor carﬁlzomib were examined by immunoblot and ﬂow cytometry analysis. The anticancer efﬁcacy of OTX015 and carﬁlzomib combination therapy was investigated in mice xenografted with TERT-rearranged neuroblastoma cell lines or patient-derived xenograft (PDX) tumor cells, and the role of TERT reduction in the anticancer efﬁcacy was examined through rescue experiments in mice. Results: The BET bromodomain protein BRD4 promoted TERT-rearranged neuroblastoma cell proliferation through upregulating TERT expression. Screening of an approved oncology drug library identiﬁed the proteasome inhibitor carﬁlzomib as the agent exerting the best synergistic anticancer effects with BET bromodomain inhibitors including OTX015. OTX015 and carﬁlzomib synergistically reduced TERT protein expression, induced endoplasmic reticulum stress, and induced TERT-rearranged neuroblastoma cell apoptosis which was blocked by TERT overexpression and endoplasmic reticulum stress antagonists. In mice xenografted with TERT-rearranged neuroblastoma cell lines or PDX tumor cells, OTX015 and carﬁlzomib synergistically blocked TERT expression, induced tumor cell apoptosis, suppressed tumor progression, and improved mouse survival, which was largely reversed by forced TERT overexpression. Conclusions: OTX015 and carﬁlzomib combination therapy is likely to be translated into the ﬁrst clinical trial of a targeted therapy in patients with TERT-rearranged neuroblastoma.
Published: 2021

34. Clinical care of pregnant and postpartum women with COVID-19: Living recommendations from the National COVID-19 Clinical Evidence Taskforce.

Author: Burgess P., Morphet J., Nou S., Russo P., Sarson M., Young A., Norris S., Morris-Donovan B., Gurry S., Hudson E., Hurley S., Primmer D., Timms S., Whicker S., Mukherjee S., Booth K., Cameron P., Cooper M., Cheng A., Fowler P., Frydenberg M., McGloughlin S., McPhee E., Mitchell B., O'Donnell C., Parr M., Phillips J., Varndell W., Whyte I., Randall R., Brightwell R., Condon L., Deshpande A., Ehm A., Ferrie M., Muller J., Pullin L., Robinson E., Witt A., Larkins S., Morgan M., Taylor G., Agostino J., Douglas K., Ewald B., Fornasier D., Knight S., Nelson C., Peachey L., Peiris D., Driel M., Walters L., Weaver I., Burr L., Hendel S., Shekar K., Avard B., Cairns K., Glanville A., Gilroy N., Myles P., O'Sullivan R., Robinson O., Sharland C., McCarthy S., Wark P., McGoughlin S., Hodgson C., Ankravs M., Hansen K., Huckson S., Iredell J., Janerka C., Jaspers R., Litton E., Macdonald S., Peake S., Bowen A., McMullan B., Tingay D., Vasilunas N., Anderson L., Best J., Burns P., Erickson S., Fancourt N., Goff Z., Kapuya V., Keyte C., Malyon L., Wurzel D., Agar M., Lindley R., Smallwood N., Callary M., Chapman M., Good P., Jenkin P., Morgan D., Naganathan V., Srikanth V., Tuffin P., Whiting E., William L., Yates P., Barber B., Davies J., Davis J., Gwee A., Leder K., Matthews G., McMahon J., Peel T., Raftery C., Rees M., Roberts J., Seppelt I., Wibrow B., Baker R., Curnow J., Cutts B., Enjeti A., Forbes A., Ho P., Holyoak A., Liley H., McFadyen J., McQuilten Z., Merriman E., Savoia H., Tan C.W., Tran H., Ward C., Williams K., Ballard N., Bendall S., Bhanderi N., Byers L., Craig S., Ellis D., Ewald D., Fairley C., Hoggard B., Cong M.L., Morley P., Nair P., Pearce A., Turner T., Callesen H., Campbell S., Ring J., Wilson A., Henry D., Pearson S., Boyle D., Chidwick K., Chapman W., French C., Pearce C., Snelling T., Bero L., Grundy Q., Lexchin J., Mintzes B., Vogel J.P., Tendal B., Giles M., Whitehead C., Burton W., Chakraborty S., Cheyne S., Downton T., Fraile Navarro D., Gleeson G., Gordon A., Hunt J., Kitschke J., McDonald S., McDonnell N., Middleton P., Millard T., Murano M., Oats J., Tate R., White H., Elliott J., Roach V., Homer C.S.E., McGowan S., Ballenden N., Barrett T.-L., Beavis V., Saunders J.B., Buchanan T., Buchanan-Grey M., Casey D., Cowie M., Doyle J., Gnjidic D., Green S., Greenland R., Griffin K., Groombridge S., Hardy L., Hodak A., Holley A., Jovanovska V., Michaels K., Burgess P., Morphet J., Nou S., Russo P., Sarson M., Young A., Norris S., Morris-Donovan B., Gurry S., Hudson E., Hurley S., Primmer D., Timms S., Whicker S., Mukherjee S., Booth K., Cameron P., Cooper M., Cheng A., Fowler P., Frydenberg M., McGloughlin S., McPhee E., Mitchell B., O'Donnell C., Parr M., Phillips J., Varndell W., Whyte I., Randall R., Brightwell R., Condon L., Deshpande A., Ehm A., Ferrie M., Muller J., Pullin L., Robinson E., Witt A., Larkins S., Morgan M., Taylor G., Agostino J., Douglas K., Ewald B., Fornasier D., Knight S., Nelson C., Peachey L., Peiris D., Driel M., Walters L., Weaver I., Burr L., Hendel S., Shekar K., Avard B., Cairns K., Glanville A., Gilroy N., Myles P., O'Sullivan R., Robinson O., Sharland C., McCarthy S., Wark P., McGoughlin S., Hodgson C., Ankravs M., Hansen K., Huckson S., Iredell J., Janerka C., Jaspers R., Litton E., Macdonald S., Peake S., Bowen A., McMullan B., Tingay D., Vasilunas N., Anderson L., Best J., Burns P., Erickson S., Fancourt N., Goff Z., Kapuya V., Keyte C., Malyon L., Wurzel D., Agar M., Lindley R., Smallwood N., Callary M., Chapman M., Good P., Jenkin P., Morgan D., Naganathan V., Srikanth V., Tuffin P., Whiting E., William L., Yates P., Barber B., Davies J., Davis J., Gwee A., Leder K., Matthews G., McMahon J., Peel T., Raftery C., Rees M., Roberts J., Seppelt I., Wibrow B., Baker R., Curnow J., Cutts B., Enjeti A., Forbes A., Ho P., Holyoak A., Liley H., McFadyen J., McQuilten Z., Merriman E., Savoia H., Tan C.W., Tran H., Ward C., Williams K., Ballard N., Bendall S., Bhanderi N., Byers L., Craig S., Ellis D., Ewald D., Fairley C., Hoggard B., Cong M.L., Morley P., Nair P., Pearce A., Turner T., Callesen H., Campbell S., Ring J., Wilson A., Henry D., Pearson S., Boyle D., Chidwick K., Chapman W., French C., Pearce C., Snelling T., Bero L., Grundy Q., Lexchin J., Mintzes B., Vogel J.P., Tendal B., Giles M., Whitehead C., Burton W., Chakraborty S., Cheyne S., Downton T., Fraile Navarro D., Gleeson G., Gordon A., Hunt J., Kitschke J., McDonald S., McDonnell N., Middleton P., Millard T., Murano M., Oats J., Tate R., White H., Elliott J., Roach V., Homer C.S.E., McGowan S., Ballenden N., Barrett T.-L., Beavis V., Saunders J.B., Buchanan T., Buchanan-Grey M., Casey D., Cowie M., Doyle J., Gnjidic D., Green S., Greenland R., Griffin K., Groombridge S., Hardy L., Hodak A., Holley A., Jovanovska V., and Michaels K.
Abstract: To date, 18 living recommendations for the clinical care of pregnant and postpartum women with COVID-19 have been issued by the National COVID-19 Clinical Evidence Taskforce. This includes recommendations on mode of birth, delayed umbilical cord clamping, skin-to-skin contact, breastfeeding, rooming-in, antenatal corticosteroids, angiotensin-converting enzyme inhibitors, disease-modifying treatments (including dexamethasone, remdesivir and hydroxychloroquine), venous thromboembolism prophylaxis and advanced respiratory support interventions (prone positioning and extracorporeal membrane oxygenation). Through continuous evidence surveillance, these living recommendations are updated in near real-time to ensure clinicians in Australia have reliable, evidence-based guidelines for clinical decision-making. Please visit https://covid19evidence.net.au/ for the latest recommendation updates.Copyright © 2020 The Authors. Australian and New Zealand Journal of Obstetrics and Gynaecology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Obstetricians and Gynaecologists
Published: 2021

35. Oscillations In The Line-of-Sight Magnetic Field Strength In A Pore Observed By The GREGOR Infrared Spectrograph (GRIS)

Author: Nelson, C. J., Campbell, R. J., Mathioudakis, M., Nelson, C. J., Campbell, R. J., and Mathioudakis, M.
Abstract: Numerous magnetohydrodynamic oscillations have been reported within solar pores over the past decades, including in line-of-sight (LOS) velocities, intensities, and magnetic field strengths. Our aim is to identify whether high-amplitude oscillations in the LOS magnetic field strength can be detected within a pore located in Active Region 12748 and to investigate which physical mechanisms could be responsible for them. A solar pore was observed on the 1st September 2019 using the GREGOR Infrared Spectrograph for around one hour. Full-Stokes vectors were sampled in a 37 A window containing the Fe I 15648.52 A line (effective Lande g-factor of 3). The LOS magnetic field strength is inferred using the strong-field approximation. The Stokes Inversion based on Response functions code is used to gain a more complete understanding the properties of the solar atmosphere at the locations of these oscillations. Oscillations of more than 100 G are observed in the LOS magnetic field in the period window 600-1272 s at three localised (>1"^2) regions. These oscillations have coherence across individual regions indicating that jitter cannot account for their occurrence. Longer-period amplitude variations, amplitudes over 200 G, are also detected but these have periods outside of the cone-of-influence. Numerical inversions confirm both oscillations in the LOS magnetic field strength at optical depths of around log-tau_5000=-0.5 (potentially caused by compression) and other effects (e.g., changes in the optical depth or the inclination of the field) may account for these changes. The oscillations in the separations of the Stokes-V lobes of the 15648.52 A line appear to be solar in nature. Future work will be required to understand whether these are truly oscillations in the magnetic field strength at a specific depth in the solar atmosphere or whether other effects are responsible for these signatures., Comment: 11 pages, 8 figures, 2 tables, Accepted for A&A
Published: 2021
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36. Clinical care of pregnant and postpartum women with COVID-19: Living recommendations from the National COVID-19 Clinical Evidence Taskforce.

Author: Burgess P., Morphet J., Nou S., Russo P., Sarson M., Young A., Norris S., Morris-Donovan B., Gurry S., Hudson E., Hurley S., Primmer D., Timms S., Whicker S., Mukherjee S., Booth K., Cameron P., Cooper M., Cheng A., Fowler P., Frydenberg M., McGloughlin S., McPhee E., Mitchell B., O'Donnell C., Parr M., Phillips J., Varndell W., Whyte I., Randall R., Brightwell R., Condon L., Deshpande A., Ehm A., Ferrie M., Muller J., Pullin L., Robinson E., Witt A., Larkins S., Morgan M., Taylor G., Agostino J., Douglas K., Ewald B., Fornasier D., Knight S., Nelson C., Peachey L., Peiris D., Driel M., Walters L., Weaver I., Burr L., Hendel S., Shekar K., Avard B., Cairns K., Glanville A., Gilroy N., Myles P., O'Sullivan R., Robinson O., Sharland C., McCarthy S., Wark P., McGoughlin S., Hodgson C., Ankravs M., Hansen K., Huckson S., Iredell J., Janerka C., Jaspers R., Litton E., Macdonald S., Peake S., Bowen A., McMullan B., Tingay D., Vasilunas N., Anderson L., Best J., Burns P., Erickson S., Fancourt N., Goff Z., Kapuya V., Keyte C., Malyon L., Wurzel D., Agar M., Lindley R., Smallwood N., Callary M., Chapman M., Good P., Jenkin P., Morgan D., Naganathan V., Srikanth V., Tuffin P., Whiting E., William L., Yates P., Barber B., Davies J., Davis J., Gwee A., Leder K., Matthews G., McMahon J., Peel T., Raftery C., Rees M., Roberts J., Seppelt I., Wibrow B., Baker R., Curnow J., Cutts B., Enjeti A., Forbes A., Ho P., Holyoak A., Liley H., McFadyen J., McQuilten Z., Merriman E., Savoia H., Tan C.W., Tran H., Ward C., Williams K., Ballard N., Bendall S., Bhanderi N., Byers L., Craig S., Ellis D., Ewald D., Fairley C., Hoggard B., Cong M.L., Morley P., Nair P., Pearce A., Turner T., Callesen H., Campbell S., Ring J., Wilson A., Henry D., Pearson S., Boyle D., Chidwick K., Chapman W., French C., Pearce C., Snelling T., Bero L., Grundy Q., Lexchin J., Mintzes B., Vogel J.P., Tendal B., Giles M., Whitehead C., Burton W., Chakraborty S., Cheyne S., Downton T., Fraile Navarro D., Gleeson G., Gordon A., Hunt J., Kitschke J., McDonald S., McDonnell N., Middleton P., Millard T., Murano M., Oats J., Tate R., White H., Elliott J., Roach V., Homer C.S.E., McGowan S., Ballenden N., Barrett T.-L., Beavis V., Saunders J.B., Buchanan T., Buchanan-Grey M., Casey D., Cowie M., Doyle J., Gnjidic D., Green S., Greenland R., Griffin K., Groombridge S., Hardy L., Hodak A., Holley A., Jovanovska V., Michaels K., Burgess P., Morphet J., Nou S., Russo P., Sarson M., Young A., Norris S., Morris-Donovan B., Gurry S., Hudson E., Hurley S., Primmer D., Timms S., Whicker S., Mukherjee S., Booth K., Cameron P., Cooper M., Cheng A., Fowler P., Frydenberg M., McGloughlin S., McPhee E., Mitchell B., O'Donnell C., Parr M., Phillips J., Varndell W., Whyte I., Randall R., Brightwell R., Condon L., Deshpande A., Ehm A., Ferrie M., Muller J., Pullin L., Robinson E., Witt A., Larkins S., Morgan M., Taylor G., Agostino J., Douglas K., Ewald B., Fornasier D., Knight S., Nelson C., Peachey L., Peiris D., Driel M., Walters L., Weaver I., Burr L., Hendel S., Shekar K., Avard B., Cairns K., Glanville A., Gilroy N., Myles P., O'Sullivan R., Robinson O., Sharland C., McCarthy S., Wark P., McGoughlin S., Hodgson C., Ankravs M., Hansen K., Huckson S., Iredell J., Janerka C., Jaspers R., Litton E., Macdonald S., Peake S., Bowen A., McMullan B., Tingay D., Vasilunas N., Anderson L., Best J., Burns P., Erickson S., Fancourt N., Goff Z., Kapuya V., Keyte C., Malyon L., Wurzel D., Agar M., Lindley R., Smallwood N., Callary M., Chapman M., Good P., Jenkin P., Morgan D., Naganathan V., Srikanth V., Tuffin P., Whiting E., William L., Yates P., Barber B., Davies J., Davis J., Gwee A., Leder K., Matthews G., McMahon J., Peel T., Raftery C., Rees M., Roberts J., Seppelt I., Wibrow B., Baker R., Curnow J., Cutts B., Enjeti A., Forbes A., Ho P., Holyoak A., Liley H., McFadyen J., McQuilten Z., Merriman E., Savoia H., Tan C.W., Tran H., Ward C., Williams K., Ballard N., Bendall S., Bhanderi N., Byers L., Craig S., Ellis D., Ewald D., Fairley C., Hoggard B., Cong M.L., Morley P., Nair P., Pearce A., Turner T., Callesen H., Campbell S., Ring J., Wilson A., Henry D., Pearson S., Boyle D., Chidwick K., Chapman W., French C., Pearce C., Snelling T., Bero L., Grundy Q., Lexchin J., Mintzes B., Vogel J.P., Tendal B., Giles M., Whitehead C., Burton W., Chakraborty S., Cheyne S., Downton T., Fraile Navarro D., Gleeson G., Gordon A., Hunt J., Kitschke J., McDonald S., McDonnell N., Middleton P., Millard T., Murano M., Oats J., Tate R., White H., Elliott J., Roach V., Homer C.S.E., McGowan S., Ballenden N., Barrett T.-L., Beavis V., Saunders J.B., Buchanan T., Buchanan-Grey M., Casey D., Cowie M., Doyle J., Gnjidic D., Green S., Greenland R., Griffin K., Groombridge S., Hardy L., Hodak A., Holley A., Jovanovska V., and Michaels K.
Abstract: To date, 18 living recommendations for the clinical care of pregnant and postpartum women with COVID-19 have been issued by the National COVID-19 Clinical Evidence Taskforce. This includes recommendations on mode of birth, delayed umbilical cord clamping, skin-to-skin contact, breastfeeding, rooming-in, antenatal corticosteroids, angiotensin-converting enzyme inhibitors, disease-modifying treatments (including dexamethasone, remdesivir and hydroxychloroquine), venous thromboembolism prophylaxis and advanced respiratory support interventions (prone positioning and extracorporeal membrane oxygenation). Through continuous evidence surveillance, these living recommendations are updated in near real-time to ensure clinicians in Australia have reliable, evidence-based guidelines for clinical decision-making. Please visit https://covid19evidence.net.au/ for the latest recommendation updates.Copyright © 2020 The Authors. Australian and New Zealand Journal of Obstetrics and Gynaecology published by John Wiley & Sons Australia, Ltd on behalf of Royal Australian and New Zealand College of Obstetricians and Gynaecologists
Published: 2021

37. Towards optimising chronic kidney disease detection and management in primary care: Underlying theory and protocol for technology development using an Integrated Knowledge Translation approach

Author: Manski-Nankervis, J-A, Alexander, K, Biezen, R, Jones, J, Hunter, B, Emery, J, Lumsden, N, Boyle, D, Gunn, J, McMorrow, R, Prictor, M, Taylor, M, Hallinan, C, Chondros, P, Janus, E, McIntosh, J, Nelson, C, Manski-Nankervis, J-A, Alexander, K, Biezen, R, Jones, J, Hunter, B, Emery, J, Lumsden, N, Boyle, D, Gunn, J, McMorrow, R, Prictor, M, Taylor, M, Hallinan, C, Chondros, P, Janus, E, McIntosh, J, and Nelson, C
Abstract: Worldwide, Chronic Kidney Disease (CKD), directly or indirectly, causes more than 2.4 million deaths annually with symptoms generally presenting late in the disease course. Clinical guidelines support the early identification and treatment of CKD to delay progression and improve clinical outcomes. This paper reports the protocol for the codesign, implementation and evaluation of a technological platform called Future Health Today (FHT), a software program that aims to optimise early detection and management of CKD in general practice. FHT aims to optimise clinical decision making and reduce practice variation by translating evidence into practice in real time and as a part of quality improvement activities. This protocol describes the co-design and plans for implementation and evaluation of FHT in two general practices invited to test the prototype over 12 months. Service design thinking has informed the design phase and mixed methods will evaluate outcomes following implementation of FHT. Through systematic application of co-design with service users, clinicians and digital technologists, FHT attempts to avoid the pitfalls of past studies that have failed to accommodate the complex requirements and dynamics that can arise between researchers and service users and improve chronic disease management through use of health information technology.
Published: 2021

38. Adaptive immunity to human coronaviruses is widespread but low in magnitude

Author: Tan, H-X, Lee, WS, Wragg, K, Nelson, C, Esterbauer, R, Kelly, H, Amarasena, T, Jones, R, Starkey, G, Wang, BZ, Yoshino, O, Tiang, T, Grayson, L, Opdam, H, D’Costa, R, Vago, A, The Austin Liver Transplant Perfusionist Group, Mackay, L, Gordon, C, Wheatley, A, Kent, S, Juno, J, Tan, H-X, Lee, WS, Wragg, K, Nelson, C, Esterbauer, R, Kelly, H, Amarasena, T, Jones, R, Starkey, G, Wang, BZ, Yoshino, O, Tiang, T, Grayson, L, Opdam, H, D’Costa, R, Vago, A, The Austin Liver Transplant Perfusionist Group, Mackay, L, Gordon, C, Wheatley, A, Kent, S, and Juno, J
Abstract: Endemic human coronaviruses (hCoV) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV-specific T cell memory in adults. We quantified CD4 T cell and antibody responses to hCoV spike antigens in 42 SARS-CoV-2 uninfected individuals. T cell responses were widespread within conventional memory and cTFH compartments but did not correlate with IgG titres. SARS-CoV-2 cross-reactive T cells were observed in 48% of participants and correlated with HKU1 memory. hCoV-specific T cells exhibited a CCR6 + central memory phenotype in the blood, but were enriched for frequency and CXCR3 expression in human lung draining lymph nodes. Overall, hCoV-specific humoral and cellular memory are independently maintained, with a shared phenotype existing among coronavirus-specific CD4 T cells. This understanding of endemic coronavirus immunity provides insight into the homeostatic maintenance of immune responses that are likely to be critical components of protection against SARS-CoV-2.
Published: 2021

39. Adaptive immunity to human coronaviruses is widespread but low in magnitude

Author: Tan, H-X, Lee, WS, Wragg, KM, Nelson, C, Esterbauer, R, Kelly, HG, Amarasena, T, Jones, R, Starkey, G, Wang, BZ, Yoshino, O, Tiang, T, Grayson, ML, Opdam, H, D'Costa, R, Vago, A, Mackay, LK, Gordon, CL, Wheatley, AK, Kent, SJ, Juno, JA, Tan, H-X, Lee, WS, Wragg, KM, Nelson, C, Esterbauer, R, Kelly, HG, Amarasena, T, Jones, R, Starkey, G, Wang, BZ, Yoshino, O, Tiang, T, Grayson, ML, Opdam, H, D'Costa, R, Vago, A, Mackay, LK, Gordon, CL, Wheatley, AK, Kent, SJ, and Juno, JA
Abstract: OBJECTIVES: Endemic human coronaviruses (hCoVs) circulate worldwide but cause minimal mortality. Although seroconversion to hCoV is near ubiquitous during childhood, little is known about hCoV-specific T-cell memory in adults. METHODS: We quantified CD4 T-cell and antibody responses to hCoV spike antigens in 42 SARS-CoV-2-uninfected individuals. Antigen-specific memory T cells and circulating T follicular helper (cTFH) cells were identified using an activation-induced marker assay and characterised for memory phenotype and chemokine receptor expression. RESULTS: T-cell responses were widespread within conventional memory and cTFH compartments but did not correlate with IgG titres. SARS-CoV-2 cross-reactive T cells were observed in 48% of participants and correlated with HKU1 memory. hCoV-specific T cells exhibited a CCR6+ central memory phenotype in the blood, but were enriched for frequency and CXCR3 expression in human lung-draining lymph nodes. CONCLUSION: Overall, hCoV-specific humoral and cellular memory are independently maintained, with a shared phenotype existing among coronavirus-specific CD4 T cells. This understanding of endemic coronavirus immunity provides insight into the homeostatic maintenance of immune responses that are likely to be critical components of protection against SARS-CoV-2.
Published: 2021

40. The long non-coding RNA GHSROS reprograms prostate cancer cell lines toward a more aggressive phenotype

Author: Thomas, P.B., Jeffery, P., Gahete, M.D., Whiteside, E., Walpole, C., Maugham, M., Jovanovic, L., Gunter, J., Williams, E., Nelson, C., Herington, A., Luque, R.M., Veedu, R., Chopin, L.K., Seim, I., Thomas, P.B., Jeffery, P., Gahete, M.D., Whiteside, E., Walpole, C., Maugham, M., Jovanovic, L., Gunter, J., Williams, E., Nelson, C., Herington, A., Luque, R.M., Veedu, R., Chopin, L.K., and Seim, I.
Abstract: It is now appreciated that long non-coding RNAs (lncRNAs) are important players in orchestrating cancer progression. In this study we characterized GHSROS, a human lncRNA gene on the opposite DNA strand (antisense) to the ghrelin receptor gene, in prostate cancer. The lncRNA was upregulated by prostate tumors from different clinical datasets. Transcriptome data revealed that GHSROS alters the expression of cancer-associated genes. Functional analyses in vitro showed that GHSROS mediates tumor growth, migration and survival, and resistance to the cytotoxic drug docetaxel. Increased cellular proliferation of GHSROS-overexpressing PC3, DU145, and LNCaP prostate cancer cell lines in vitro was recapitulated in a subcutaneous xenograft model. Conversely, in vitro antisense oligonucleotide inhibition of the lncRNA reciprocally regulated cell growth and migration, and gene expression. Notably, GHSROS modulates the expression of PPP2R2C, the loss of which may drive androgen receptor pathway-independent prostate tumor progression in a subset of prostate cancers. Collectively, our findings suggest that GHSROS can reprogram prostate cancer cells toward a more aggressive phenotype and that this lncRNA may represent a potential therapeutic target.
Published: 2021

41. Charge density waves in cuprate superconductors beyond the critical doping

Author: Miao H., Fabbris G., Koch R. J., Mazzone D. G., Nelson C. S., Acevedo-Esteves R., Gu G. D., Li Y., Yilimaz T., Kaznatcheev K., Vescovo E., Oda M., Kurosawa T., Momono N., Assefa T., Robinson I. K., Bozin E. S., Tranquada J. M., Johnson P. D., Dean M. P. M., Miao H., Fabbris G., Koch R. J., Mazzone D. G., Nelson C. S., Acevedo-Esteves R., Gu G. D., Li Y., Yilimaz T., Kaznatcheev K., Vescovo E., Oda M., Kurosawa T., Momono N., Assefa T., Robinson I. K., Bozin E. S., Tranquada J. M., Johnson P. D., and Dean M. P. M.
Abstract: The unconventional normal-state properties of the cuprates are often discussed in terms of emergent electronic order that onsets below a putative critical doping of x(c)approximate to 0.19. Charge density wave (CDW) correlations represent one such order; however, experimental evidence for such order generally spans a limited range of doping that falls short of the critical value x(c), leading to questions regarding its essential relevance. Here, we use X-ray diffraction to demonstrate that CDW correlations in La2-xSrxCuO4 persist up to a doping of at least x=0.21. The correlations show strong changes through the superconducting transition, but no obvious discontinuity through x(c)approximate to 0.19, despite changes in Fermi surface topology and electronic transport at this doping. These results demonstrate the interaction between CDWs and superconductivity even in overdoped cuprates and prompt a reconsideration of the role of CDW correlations in the high-temperature cuprate phase diagram.
Published: 2021

42. Charge density waves in cuprate superconductors beyond the critical doping

Author: Miao H., Fabbris G., Koch R. J., Mazzone D. G., Nelson C. S., Acevedo-Esteves R., Gu G. D., Li Y., Yilimaz T., Kaznatcheev K., Vescovo E., Oda M., Kurosawa T., Momono N., Assefa T., Robinson I. K., Bozin E. S., Tranquada J. M., Johnson P. D., Dean M. P. M., Miao H., Fabbris G., Koch R. J., Mazzone D. G., Nelson C. S., Acevedo-Esteves R., Gu G. D., Li Y., Yilimaz T., Kaznatcheev K., Vescovo E., Oda M., Kurosawa T., Momono N., Assefa T., Robinson I. K., Bozin E. S., Tranquada J. M., Johnson P. D., and Dean M. P. M.
Abstract: The unconventional normal-state properties of the cuprates are often discussed in terms of emergent electronic order that onsets below a putative critical doping of x(c)approximate to 0.19. Charge density wave (CDW) correlations represent one such order; however, experimental evidence for such order generally spans a limited range of doping that falls short of the critical value x(c), leading to questions regarding its essential relevance. Here, we use X-ray diffraction to demonstrate that CDW correlations in La2-xSrxCuO4 persist up to a doping of at least x=0.21. The correlations show strong changes through the superconducting transition, but no obvious discontinuity through x(c)approximate to 0.19, despite changes in Fermi surface topology and electronic transport at this doping. These results demonstrate the interaction between CDWs and superconductivity even in overdoped cuprates and prompt a reconsideration of the role of CDW correlations in the high-temperature cuprate phase diagram.
Published: 2021

43. A mosquito small RNA genomics resource reveals dynamic evolution and host responses to viruses and transposons.

Author: Ma, Qicheng, Ma, Qicheng, Srivastav, Satyam P, Gamez, Stephanie, Dayama, Gargi, Feitosa-Suntheimer, Fabiana, Patterson, Edward I, Johnson, Rebecca M, Matson, Erik M, Gold, Alexander S, Brackney, Douglas E, Connor, John H, Colpitts, Tonya M, Hughes, Grant L, Rasgon, Jason L, Nolan, Tony, Akbari, Omar S, Lau, Nelson C, Ma, Qicheng, Ma, Qicheng, Srivastav, Satyam P, Gamez, Stephanie, Dayama, Gargi, Feitosa-Suntheimer, Fabiana, Patterson, Edward I, Johnson, Rebecca M, Matson, Erik M, Gold, Alexander S, Brackney, Douglas E, Connor, John H, Colpitts, Tonya M, Hughes, Grant L, Rasgon, Jason L, Nolan, Tony, Akbari, Omar S, and Lau, Nelson C
Abstract: Although mosquitoes are major transmission vectors for pathogenic arboviruses, viral infection has little impact on mosquito health. This immunity is caused in part by mosquito RNA interference (RNAi) pathways that generate antiviral small interfering RNAs (siRNAs) and Piwi-interacting RNAs (piRNAs). RNAi also maintains genome integrity by potently repressing mosquito transposon activity in the germline and soma. However, viral and transposon small RNA regulatory pathways have not been systematically examined together in mosquitoes. Therefore, we developed an integrated mosquito small RNA genomics (MSRG) resource that analyzes the transposon and virus small RNA profiles in mosquito cell cultures and somatic and gonadal tissues across four medically important mosquito species. Our resource captures both somatic and gonadal small RNA expression profiles within mosquito cell cultures, and we report the evolutionary dynamics of a novel Mosquito-Conserved piRNA Cluster Locus (MCpiRCL) made up of satellite DNA repeats. In the larger culicine mosquito genomes we detected highly regular periodicity in piRNA biogenesis patterns coinciding with the expansion of Piwi pathway genes. Finally, our resource enables detection of cross talk between piRNA and siRNA populations in mosquito cells during a response to virus infection. The MSRG resource will aid efforts to dissect and combat the capacity of mosquitoes to tolerate and spread arboviruses.
Published: 2021

44. The power of genetic diversity in genome-wide association studies of lipids

Author: Graham, S. E. (Sarah E.), Clarke, S. L. (Shoa L.), Wu, K. H. (Kuan-Han H.), Kanoni, S. (Stavroula), Zajac, G. J. (Greg J. M.), Ramdas, S. (Shweta), Surakka, I. (Ida), Ntalla, I. (Ioanna), Vedantam, S. (Sailaja), Winkler, T. W. (Thomas W.), Locke, A. E. (Adam E.), Marouli, E. (Eirini), Hwang, M. Y. (Mi Yeong), Han, S. (Sohee), Narita, A. (Akira), Choudhury, A. (Ananyo), Bentley, A. R. (Amy R.), Ekoru, K. (Kenneth), Verma, A. (Anurag), Trivedi, B. (Bhavi), Martin, H. C. (Hilary C.), Hunt, K. A. (Karen A.), Hui, Q. (Qin), Klarin, D. (Derek), Zhu, X. (Xiang), Thorleifsson, G. (Gudmar), Helgadottir, A. (Anna), Gudbjartsson, D. F. (Daniel F.), Holm, H. (Hilma), Olafsson, I. (Isleifur), Akiyama, M. (Masato), Sakaue, S. (Saori), Terao, C. (Chikashi), Kanai, M. (Masahiro), Zhou, W. (Wei), Brumpton, B. M. (Ben M.), Rasheed, H. (Humaira), Ruotsalainen, S. E. (Sanni E.), Havulinna, A. S. (Aki S.), Veturi, Y. (Yogasudha), Feng, Q. (QiPing), Rosenthal, E. A. (Elisabeth A.), Lingren, T. (Todd), Pacheco, J. A. (Jennifer Allen), Pendergrass, S. A. (Sarah A.), Haessler, J. (Jeffrey), Giulianini, F. (Franco), Bradford, Y. (Yuki), Miller, J. E. (Jason E.), Campbell, A. (Archie), Lin, K. (Kuang), Millwood, I. Y. (Iona Y.), Hindy, G. (George), Rasheed, A. (Asif), Faul, J. D. (Jessica D.), Zhao, W. (Wei), Weir, D. R. (David R.), Turman, C. (Constance), Huang, H. (Hongyan), Graff, M. (Mariaelisa), Mahajan, A. (Anubha), Brown, M. R. (Michael R.), Zhang, W. (Weihua), Yu, K. (Ketian), Schmidt, E. M. (Ellen M.), Pandit, A. (Anita), Gustafsson, S. (Stefan), Yin, X. (Xianyong), Luan, J. (Jian'an), Zhao, J.-H. (Jing-Hua), Matsuda, F. (Fumihiko), Jang, H.-M. (Hye-Mi), Yoon, K. (Kyungheon), Medina-Gomez, C. (Carolina), Pitsillides, A. (Achilleas), Hottenga, J. J. (Jouke Jan), Willemsen, G. (Gonneke), Wood, A. R. (Andrew R.), Ji, Y. (Yingji), Gao, Z. (Zishan), Haworth, S. (Simon), Mitchell, R. E. (Ruth E.), Chai, J. F. (Jin Fang), Aadahl, M. (Mette), Yao, J. (Jie), Manichaikul, A. (Ani), Warren, H. R. (Helen R.), Ramirez, J. (Julia), Bork-Jensen, J. (Jette), Karhus, L. L. (Line L.), Goel, A. (Anuj), Sabater-Lleal, M. (Maria), Noordam, R. (Raymond), Sidore, C. (Carlo), Fiorillo, E. (Edoardo), McDaid, A. F. (Aaron F.), Marques-Vidal, P. (Pedro), Wielscher, M. (Matthias), Trompet, S. (Stella), Sattar, N. (Naveed), Mollehave, L. T. (Line T.), Thuesen, B. H. (Betina H.), Munz, M. (Matthias), Zeng, L. (Lingyao), Huang, J. (Jianfeng), Yang, B. (Bin), Poveda, A. (Alaitz), Kurbasic, A. (Azra), Lamina, C. (Claudia), Forer, L. (Lukas), Scholz, M. (Markus), Galesloot, T. E. (Tessel E.), Bradfield, J. P. (Jonathan P.), Daw, E. W. (E. Warwick), Zmuda, J. M. (Joseph M.), Mitchell, J. S. (Jonathan S.), Fuchsberger, C. (Christian), Christensen, H. (Henry), Brody, J. A. (Jennifer A.), Feitosa, M. F. (Mary F.), Wojczynski, M. K. (Mary K.), Preuss, M. (Michael), Mangino, M. (Massimo), Christofidou, P. (Paraskevi), Verweij, N. (Niek), Benjamins, J. W. (Jan W.), Engmann, J. (Jorgen), Kember, R. L. (Rachel L.), Slieker, R. C. (Roderick C.), Lo, K. S. (Ken Sin), Zilhao, N. R. (Nuno R.), Kleber, M. E. (Marcus E.), Delgado, G. E. (Graciela E.), Huo, S. (Shaofeng), Ikeda, D. D. (Daisuke D.), Iha, H. (Hiroyuki), Yang, J. (Jian), Liu, J. (Jun), Leonard, H. L. (Hampton L.), Marten, J. (Jonathan), Schmidt, B. (Borge), Arendt, M. (Marina), Smyth, L. J. (Laura J.), Canadas-Garre, M. (Marisa), Wang, C. (Chaolong), Nakatochi, M. (Masahiro), Wong, A. (Andrew), Hutri-Kahonen, N. (Nina), Sim, X. (Xueling), Xia, R. (Rui), Huerta-Chagoya, A. (Alicia), Fernandez-Lopez, J. C. (Juan Carlos), Lyssenko, V. (Valeriya), Ahmed, M. (Meraj), Jackson, A. U. (Anne U.), Irvin, M. R. (Marguerite R.), Oldmeadow, C. (Christopher), Kim, H.-N. (Han-Na), Ryu, S. (Seungho), Timmers, P. R. (Paul R. H. J.), Arbeeva, L. (Liubov), Dorajoo, R. (Rajkumar), Lange, L. A. (Leslie A.), Chai, X. (Xiaoran), Prasad, G. (Gauri), Lores-Motta, L. (Laura), Pauper, M. (Marc), Long, J. (Jirong), Li, X. (Xiaohui), Theusch, E. (Elizabeth), Takeuchi, F. (Fumihiko), Spracklen, C. N. (Cassandra N.), Loukola, A. (Anu), Bollepalli, S. (Sailalitha), Warner, S. C. (Sophie C.), Wang, Y. X. (Ya Xing), Wei, W. B. (Wen B.), Nutile, T. (Teresa), Ruggiero, D. (Daniela), Sung, Y. J. (Yun Ju), Hung, Y.-J. (Yi-Jen), Chen, S. (Shufeng), Liu, F. (Fangchao), Yang, J. (Jingyun), Kentistou, K. A. (Katherine A.), Gorski, M. (Mathias), Brumat, M. (Marco), Meidtner, K. (Karina), Bielak, L. F. (Lawrence F.), Smith, J. A. (Jennifer A.), Hebbar, P. (Prashantha), Farmaki, A.-E. (Aliki-Eleni), Hofer, E. (Edith), Lin, M. (Maoxuan), Xue, C. (Chao), Zhang, J. (Jifeng), Concas, M. P. (Maria Pina), Vaccargiu, S. (Simona), van der Most, P. J. (Peter J.), Pitkanen, N. (Niina), Cade, B. E. (Brian E.), Lee, J. (Jiwon), van Der Laan, S. W. (Sander W.), Chitrala, K. N. (Kumaraswamy Naidu), Weiss, S. (Stefan), Zimmermann, M. E. (Martina E.), Lee, J. Y. (Jong Young), Choi, H. S. (Hyeok Sun), Nethander, M. (Maria), Freitag-Wolf, S. (Sandra), Southam, L. (Lorraine), Rayner, N. W. (Nigel W.), Wang, C. A. (Carol A.), Lin, S.-Y. (Shih-Yi), Wang, J.-S. (Jun-Sing), Couture, C. (Christian), Lyytikainen, L.-P. (Leo-Pekka), Nikus, K. (Kjell), Cuellar-Partida, G. (Gabriel), Vestergaard, H. (Henrik), Hildalgo, B. (Bertha), Giannakopoulou, O. (Olga), Cai, Q. (Qiuyin), Obura, M. O. (Morgan O.), van Setten, J. (Jessica), Li, X. (Xiaoyin), Schwander, K. (Karen), Terzikhan, N. (Natalie), Shin, J. H. (Jae Hun), Jackson, R. D. (Rebecca D.), Reiner, A. P. (Alexander P.), Martin, L. W. (Lisa Warsinger), Chen, Z. (Zhengming), Li, L. (Liming), Highland, H. M. (Heather M.), Young, K. L. (Kristin L.), Kawaguchi, T. (Takahisa), Thiery, J. (Joachim), Bis, J. C. (Joshua C.), Nadkarni, G. N. (Girish N.), Launer, L. J. (Lenore J.), Li, H. (Huaixing), Nalls, M. A. (Mike A.), Raitakari, O. T. (Olli T.), Ichihara, S. (Sahoko), Wild, S. H. (Sarah H.), Nelson, C. P. (Christopher P.), Campbell, H. (Harry), Jager, S. (Susanne), Nabika, T. (Toru), Al-Mulla, F. (Fahd), Niinikoski, H. (Harri), Braund, P. S. (Peter S.), Kolcic, I. (Ivana), Kovacs, P. (Peter), Giardoglou, T. (Tota), Katsuya, T. (Tomohiro), Bhatti, F. (Fatima), de Kleijn, D. (Dominique), de Borst, G. J. (Gert J.), Kim, E. K. (Eung Kweon), Adams, H. H. (Hieab H. H.), Ikram, M. A. (M. Arfan), Zhu, X. (Xiaofeng), Asselbergs, F. W. (Folkert W.), Kraaijeveld, A. O. (Adriaan O.), Beulens, J. W. (Joline W. J.), Shu, X.-O. (Xiao-Ou), Rallidis, L. S. (Loukianos S.), Pedersen, O. (Oluf), Hansen, T. (Torben), Mitchell, P. (Paul), Hewitt, A. W. (Alex W.), Kahonen, M. (Mika), Perusse, L. (Louis), Bouchard, C. (Claude), Tonjes, A. (Anke), Chen, Y. I. (Yii-Der Ida), Pennell, C. E. (Craig E.), Mori, T. A. (Trevor A.), Lieb, W. (Wolfgang), Franke, A. (Andre), Ohlsson, C. (Claes), Mellstrom, D. (Dan), Cho, Y. S. (Yoon Shin), Lee, H. (Hyejin), Yuan, J.-M. (Jian-Min), Koh, W.-P. (Woon-Puay), Rhee, S. Y. (Sang Youl), Woo, J.-T. (Jeong-Taek), Heid, I. M. (Iris M.), Stark, K. J. (Klaus J.), Volzke, H. (Henry), Homuth, G. (Georg), Evans, M. K. (Michele K.), Zonderman, A. B. (Alan B.), Polasek, O. (Ozren), Pasterkamp, G. (Gerard), Hoefer, I. E. (Imo E.), Redline, S. (Susan), Pahkala, K. (Katja), Oldehinkel, A. J. (Albertine J.), Snieder, H. (Harold), Biino, G. (Ginevra), Schmidt, R. (Reinhold), Schmidt, H. (Helena), Chen, Y. E. (Y. Eugene), Bandinelli, S. (Stefania), Dedoussis, G. (George), Thanaraj, T. A. (Thangavel Alphonse), Kardia, S. L. (Sharon L. R.), Kato, N. (Norihiro), Schulze, M. B. (Matthias B.), Girotto, G. (Giorgia), Jung, B. (Bettina), Boger, C. A. (Carsten A.), Joshi, P. K. (Peter K.), Bennett, D. A. (David A.), De Jager, P. L. (Philip L.), Lu, X. (Xiangfeng), Mamakou, V. (Vasiliki), Brown, M. (Morris), Caulfield, M. J. (Mark J.), Munroe, P. B. (Patricia B.), Guo, X. (Xiuqing), Ciullo, M. (Marina), Jonas, J. B. (Jost B.), Samani, N. J. (Nilesh J.), Kaprio, J. (Jaakko), Pajukanta, P. (Paivi), Adair, L. S. (Linda S.), Bechayda, S. A. (Sonny Augustin), de Silva, H. J. (H. Janaka), Wickremasinghe, A. R. (Ananda R.), Krauss, R. M. (Ronald M.), Wu, J.-Y. (Jer-Yuarn), Zheng, W. (Wei), den Hollander, A. I. (Anneke, I), Bharadwaj, D. (Dwaipayan), Correa, A. (Adolfo), Wilson, J. G. (James G.), Lind, L. (Lars), Heng, C.-K. (Chew-Kiat), Nelson, A. E. (Amanda E.), Golightly, Y. M. (Yvonne M.), Wilson, J. F. (James F.), Penninx, B. (Brenda), Kim, H.-L. (Hyung-Lae), Attia, J. (John), Scott, R. J. (Rodney J.), Rao, D. C. (D. C.), Arnett, D. K. (Donna K.), Walker, M. (Mark), Koistinen, H. A. (Heikki A.), Chandak, G. R. (Giriraj R.), Yajnik, C. S. (Chittaranjan S.), Mercader, J. M. (Josep M.), Tusie-Luna, T. (Teresa), Aguilar-Salinas, C. A. (Carlos A.), Villalpando, C. G. (Clicerio Gonzalez), Orozco, L. (Lorena), Fornage, M. (Myriam), Tai, E. S. (E. Shyong), van Dam, R. M. (Rob M.), Lehtimaki, T. (Terho), Chaturvedi, N. (Nish), Yokota, M. (Mitsuhiro), Liu, J. (Jianjun), Reilly, D. F. (Dermot F.), McKnight, A. J. (Amy Jayne), Kee, F. (Frank), Jockel, K.-H. (Karl-Heinz), McCarthy, M. I. (Mark, I), Palmer, C. N. (Colin N. A.), Vitart, V. (Veronique), Hayward, C. (Caroline), Simonsick, E. (Eleanor), van Duijn, C. M. (Cornelia M.), Lu, F. (Fan), Qu, J. (Jia), Hishigaki, H. (Haretsugu), Lin, X. (Xu), Marz, W. (Winfried), Parra, E. J. (Esteban J.), Cruz, M. (Miguel), Gudnason, V. (Vilmundur), Tardif, J.-C. (Jean-Claude), Lettre, G. (Guillaume), Elders, P. J. (Petra J. M.), Damrauer, S. M. (Scott M.), Kumari, M. (Meena), Kivimaki, M. (Mika), van der Harst, P. (Pim), Spector, T. D. (Tim D.), Loos, R. J. (Ruth J. F.), Province, M. A. (Michael A.), Psaty, B. M. (Bruce M.), Brandslund, I. (Ivan), Pramstaller, P. P. (Peter P.), Christensen, K. (Kaare), Ripatti, S. (Samuli), Widen, E. (Elisabeth), Hakonarson, H. (Hakon), Grant, S. F. (Struan F. A.), Kiemeney, L. A. (Lambertus A. L. M.), de Graaf, J. (Jacqueline), Loeffler, M. (Markus), Kronenberg, F. (Florian), Gu, D. (Dongfeng), Erdmann, J. (Jeanette), Schunkert, H. (Heribert), Franks, P. W. (Paul W.), Linneberg, A. (Allan), Jukema, J. W. (J. Wouter), Khera, A. V. (Amit, V), Männikkö, M. (Minna), Järvelin, M.-R. (Marjo-Riitta), Kutalik, Z. (Zoltan), Cucca, F. (Francesco), Mook-Kanamori, D. O. (Dennis O.), van Dijk, K. W. (Ko Willems), Watkins, H. (Hugh), Strachan, D. P. (David P.), Grarup, N. (Niels), Sever, P. (Peter), Poulter, N. (Neil), Rotter, J. I. (Jerome, I), Dantoft, T. M. (Thomas M.), Karpe, F. (Fredrik), Neville, M. J. (Matt J.), Timpson, N. J. (Nicholas J.), Cheng, C.-Y. (Ching-Yu), Wong, T.-Y. (Tien-Yin), Khor, C. C. (Chiea Chuen), Sabanayagam, C. (Charumathi), Peters, A. (Annette), Gieger, C. (Christian), Hattersley, A. T. (Andrew T.), Pedersen, N. L. (Nancy L.), Magnusson, P. K. (Patrik K. E.), Boomsma, D. I. (Dorret, I), de Geus, E. J. (Eco J. C.), Cupples, L. A. (L. Adrienne), van Meurs, J. B. (Joyce B. J.), Ghanbari, M. (Mohsen), Rsen, P. G. (Penny Gordon-La), Huang, W. (Wei), Kim, Y. J. (Young Jin), Tabara, Y. (Yasuharu), Wareham, N. J. (Nicholas J.), Langenberg, C. (Claudia), Zeggini, E. (Eleftheria), Kuusisto, J. (Johanna), Laakso, M. (Markku), Ingelsson, E. (Erik), Abecasis, G. (Goncalo), Chambers, J. C. (John C.), Kooner, J. S. (Jaspal S.), de Vries, P. S. (Paul S.), Morrison, A. C. (Alanna C.), North, K. E. (Kari E.), Daviglus, M. (Martha), Kraft, P. (Peter), Martin, N. G. (Nicholas G.), Whitfield, J. B. (John B.), Abbas, S. (Shahid), Saleheen, D. (Danish), Walters, R. G. (Robin G.), Holmes, M. V. (Michael, V), Black, C. (Corri), Smith, B. H. (Blair H.), Justice, A. E. (Anne E.), Baras, A. (Aris), Buring, J. E. (Julie E.), Ridker, P. M. (Paul M.), Chasman, D. I. (Daniel, I), Kooperberg, C. (Charles), Wei, W.-Q. (Wei-Qi), Jarvik, G. P. (Gail P.), Namjou, B. (Bahram), Hayes, M. G. (M. Geoffrey), Ritchie, M. D. (Marylyn D.), Jousilahti, P. (Pekka), Salomaa, V. (Veikko), Hveem, K. (Kristian), Asvold, B. O. (Bjorn Olav), Kubo, M. (Michiaki), Kamatani, Y. (Yoichiro), Okada, Y. (Yukinori), Murakami, Y. (Yoshinori), Thorsteinsdottir, U. (Unnur), Stefansson, K. (Kari), Ho, Y.-L. (Yuk-Lam), Lynch, J. A. (Julie A.), Rader, D. J. (Daniel J.), Tsao, P. S. (Philip S.), Chang, K.-M. (Kyong-Mi), Cho, K. (Kelly), O'Donnell, C. J. (Christopher J.), Gaziano, J. M. (John M.), Wilson, P. (Peter), Rotimi, C. N. (Charles N.), Hazelhurst, S. (Scott), Ramsay, M. (Michele), Trembath, R. C. (Richard C.), van Heel, D. A. (David A.), Tamiya, G. (Gen), Yamamoto, M. (Masayuki), Kim, B.-J. (Bong-Jo), Mohlke, K. L. (Karen L.), Frayling, T. M. (Timothy M.), Hirschhorn, J. N. (Joel N.), Kathiresan, S. (Sekar), Boehnke, M. (Michael), Natarajan, P. (Pradeep), Peloso, G. M. (Gina M.), Brown, C. D. (Christopher D.), Morris, A. P. (Andrew P.), Assimes, T. L. (Themistocles L.), Deloukas, P. (Panos), Sun, Y. V. (Yan, V), Willer, C. J. (Cristen J.), Graham, S. E. (Sarah E.), Clarke, S. L. (Shoa L.), Wu, K. H. (Kuan-Han H.), Kanoni, S. (Stavroula), Zajac, G. J. (Greg J. M.), Ramdas, S. (Shweta), Surakka, I. (Ida), Ntalla, I. (Ioanna), Vedantam, S. (Sailaja), Winkler, T. W. (Thomas W.), Locke, A. E. (Adam E.), Marouli, E. (Eirini), Hwang, M. Y. (Mi Yeong), Han, S. (Sohee), Narita, A. (Akira), Choudhury, A. (Ananyo), Bentley, A. R. (Amy R.), Ekoru, K. (Kenneth), Verma, A. (Anurag), Trivedi, B. (Bhavi), Martin, H. C. (Hilary C.), Hunt, K. A. (Karen A.), Hui, Q. (Qin), Klarin, D. (Derek), Zhu, X. (Xiang), Thorleifsson, G. (Gudmar), Helgadottir, A. (Anna), Gudbjartsson, D. F. (Daniel F.), Holm, H. (Hilma), Olafsson, I. (Isleifur), Akiyama, M. (Masato), Sakaue, S. (Saori), Terao, C. (Chikashi), Kanai, M. (Masahiro), Zhou, W. (Wei), Brumpton, B. M. (Ben M.), Rasheed, H. (Humaira), Ruotsalainen, S. E. (Sanni E.), Havulinna, A. S. (Aki S.), Veturi, Y. (Yogasudha), Feng, Q. (QiPing), Rosenthal, E. A. (Elisabeth A.), Lingren, T. (Todd), Pacheco, J. A. (Jennifer Allen), Pendergrass, S. A. (Sarah A.), Haessler, J. (Jeffrey), Giulianini, F. (Franco), Bradford, Y. (Yuki), Miller, J. E. (Jason E.), Campbell, A. (Archie), Lin, K. (Kuang), Millwood, I. Y. (Iona Y.), Hindy, G. (George), Rasheed, A. (Asif), Faul, J. D. (Jessica D.), Zhao, W. (Wei), Weir, D. R. (David R.), Turman, C. (Constance), Huang, H. (Hongyan), Graff, M. (Mariaelisa), Mahajan, A. (Anubha), Brown, M. R. (Michael R.), Zhang, W. (Weihua), Yu, K. (Ketian), Schmidt, E. M. (Ellen M.), Pandit, A. (Anita), Gustafsson, S. (Stefan), Yin, X. (Xianyong), Luan, J. (Jian'an), Zhao, J.-H. (Jing-Hua), Matsuda, F. (Fumihiko), Jang, H.-M. (Hye-Mi), Yoon, K. (Kyungheon), Medina-Gomez, C. (Carolina), Pitsillides, A. (Achilleas), Hottenga, J. J. (Jouke Jan), Willemsen, G. (Gonneke), Wood, A. R. (Andrew R.), Ji, Y. (Yingji), Gao, Z. (Zishan), Haworth, S. (Simon), Mitchell, R. E. (Ruth E.), Chai, J. F. (Jin Fang), Aadahl, M. (Mette), Yao, J. (Jie), Manichaikul, A. (Ani), Warren, H. R. (Helen R.), Ramirez, J. (Julia), Bork-Jensen, J. (Jette), Karhus, L. L. (Line L.), Goel, A. (Anuj), Sabater-Lleal, M. (Maria), Noordam, R. (Raymond), Sidore, C. (Carlo), Fiorillo, E. (Edoardo), McDaid, A. F. (Aaron F.), Marques-Vidal, P. (Pedro), Wielscher, M. (Matthias), Trompet, S. (Stella), Sattar, N. (Naveed), Mollehave, L. T. (Line T.), Thuesen, B. H. (Betina H.), Munz, M. (Matthias), Zeng, L. (Lingyao), Huang, J. (Jianfeng), Yang, B. (Bin), Poveda, A. (Alaitz), Kurbasic, A. (Azra), Lamina, C. (Claudia), Forer, L. (Lukas), Scholz, M. (Markus), Galesloot, T. E. (Tessel E.), Bradfield, J. P. (Jonathan P.), Daw, E. W. (E. Warwick), Zmuda, J. M. (Joseph M.), Mitchell, J. S. (Jonathan S.), Fuchsberger, C. (Christian), Christensen, H. (Henry), Brody, J. A. (Jennifer A.), Feitosa, M. F. (Mary F.), Wojczynski, M. K. (Mary K.), Preuss, M. (Michael), Mangino, M. (Massimo), Christofidou, P. (Paraskevi), Verweij, N. (Niek), Benjamins, J. W. (Jan W.), Engmann, J. (Jorgen), Kember, R. L. (Rachel L.), Slieker, R. C. (Roderick C.), Lo, K. S. (Ken Sin), Zilhao, N. R. (Nuno R.), Kleber, M. E. (Marcus E.), Delgado, G. E. (Graciela E.), Huo, S. (Shaofeng), Ikeda, D. D. (Daisuke D.), Iha, H. (Hiroyuki), Yang, J. (Jian), Liu, J. (Jun), Leonard, H. L. (Hampton L.), Marten, J. (Jonathan), Schmidt, B. (Borge), Arendt, M. (Marina), Smyth, L. J. (Laura J.), Canadas-Garre, M. (Marisa), Wang, C. (Chaolong), Nakatochi, M. (Masahiro), Wong, A. (Andrew), Hutri-Kahonen, N. (Nina), Sim, X. (Xueling), Xia, R. (Rui), Huerta-Chagoya, A. (Alicia), Fernandez-Lopez, J. C. (Juan Carlos), Lyssenko, V. (Valeriya), Ahmed, M. (Meraj), Jackson, A. U. (Anne U.), Irvin, M. R. (Marguerite R.), Oldmeadow, C. (Christopher), Kim, H.-N. (Han-Na), Ryu, S. (Seungho), Timmers, P. R. (Paul R. H. J.), Arbeeva, L. (Liubov), Dorajoo, R. (Rajkumar), Lange, L. A. (Leslie A.), Chai, X. (Xiaoran), Prasad, G. (Gauri), Lores-Motta, L. (Laura), Pauper, M. (Marc), Long, J. (Jirong), Li, X. (Xiaohui), Theusch, E. (Elizabeth), Takeuchi, F. (Fumihiko), Spracklen, C. N. (Cassandra N.), Loukola, A. (Anu), Bollepalli, S. (Sailalitha), Warner, S. C. (Sophie C.), Wang, Y. X. (Ya Xing), Wei, W. B. (Wen B.), Nutile, T. (Teresa), Ruggiero, D. (Daniela), Sung, Y. J. (Yun Ju), Hung, Y.-J. (Yi-Jen), Chen, S. (Shufeng), Liu, F. (Fangchao), Yang, J. (Jingyun), Kentistou, K. A. (Katherine A.), Gorski, M. (Mathias), Brumat, M. (Marco), Meidtner, K. (Karina), Bielak, L. F. (Lawrence F.), Smith, J. A. (Jennifer A.), Hebbar, P. (Prashantha), Farmaki, A.-E. (Aliki-Eleni), Hofer, E. (Edith), Lin, M. (Maoxuan), Xue, C. (Chao), Zhang, J. (Jifeng), Concas, M. P. (Maria Pina), Vaccargiu, S. (Simona), van der Most, P. J. (Peter J.), Pitkanen, N. (Niina), Cade, B. E. (Brian E.), Lee, J. (Jiwon), van Der Laan, S. W. (Sander W.), Chitrala, K. N. (Kumaraswamy Naidu), Weiss, S. (Stefan), Zimmermann, M. E. (Martina E.), Lee, J. Y. (Jong Young), Choi, H. S. (Hyeok Sun), Nethander, M. (Maria), Freitag-Wolf, S. (Sandra), Southam, L. (Lorraine), Rayner, N. W. (Nigel W.), Wang, C. A. (Carol A.), Lin, S.-Y. (Shih-Yi), Wang, J.-S. (Jun-Sing), Couture, C. (Christian), Lyytikainen, L.-P. (Leo-Pekka), Nikus, K. (Kjell), Cuellar-Partida, G. (Gabriel), Vestergaard, H. (Henrik), Hildalgo, B. (Bertha), Giannakopoulou, O. (Olga), Cai, Q. (Qiuyin), Obura, M. O. (Morgan O.), van Setten, J. (Jessica), Li, X. (Xiaoyin), Schwander, K. (Karen), Terzikhan, N. (Natalie), Shin, J. H. (Jae Hun), Jackson, R. D. (Rebecca D.), Reiner, A. P. (Alexander P.), Martin, L. W. (Lisa Warsinger), Chen, Z. (Zhengming), Li, L. (Liming), Highland, H. M. (Heather M.), Young, K. L. (Kristin L.), Kawaguchi, T. (Takahisa), Thiery, J. (Joachim), Bis, J. C. (Joshua C.), Nadkarni, G. N. (Girish N.), Launer, L. J. (Lenore J.), Li, H. (Huaixing), Nalls, M. A. (Mike A.), Raitakari, O. T. (Olli T.), Ichihara, S. (Sahoko), Wild, S. H. (Sarah H.), Nelson, C. P. (Christopher P.), Campbell, H. (Harry), Jager, S. (Susanne), Nabika, T. (Toru), Al-Mulla, F. (Fahd), Niinikoski, H. (Harri), Braund, P. S. (Peter S.), Kolcic, I. (Ivana), Kovacs, P. (Peter), Giardoglou, T. (Tota), Katsuya, T. (Tomohiro), Bhatti, F. (Fatima), de Kleijn, D. (Dominique), de Borst, G. J. (Gert J.), Kim, E. K. (Eung Kweon), Adams, H. H. (Hieab H. H.), Ikram, M. A. (M. Arfan), Zhu, X. (Xiaofeng), Asselbergs, F. W. (Folkert W.), Kraaijeveld, A. O. (Adriaan O.), Beulens, J. W. (Joline W. J.), Shu, X.-O. (Xiao-Ou), Rallidis, L. S. (Loukianos S.), Pedersen, O. (Oluf), Hansen, T. (Torben), Mitchell, P. (Paul), Hewitt, A. W. (Alex W.), Kahonen, M. (Mika), Perusse, L. (Louis), Bouchard, C. (Claude), Tonjes, A. (Anke), Chen, Y. I. (Yii-Der Ida), Pennell, C. E. (Craig E.), Mori, T. A. (Trevor A.), Lieb, W. (Wolfgang), Franke, A. (Andre), Ohlsson, C. (Claes), Mellstrom, D. (Dan), Cho, Y. S. (Yoon Shin), Lee, H. (Hyejin), Yuan, J.-M. (Jian-Min), Koh, W.-P. (Woon-Puay), Rhee, S. Y. (Sang Youl), Woo, J.-T. (Jeong-Taek), Heid, I. M. (Iris M.), Stark, K. J. (Klaus J.), Volzke, H. (Henry), Homuth, G. (Georg), Evans, M. K. (Michele K.), Zonderman, A. B. (Alan B.), Polasek, O. (Ozren), Pasterkamp, G. (Gerard), Hoefer, I. E. (Imo E.), Redline, S. (Susan), Pahkala, K. (Katja), Oldehinkel, A. J. (Albertine J.), Snieder, H. (Harold), Biino, G. (Ginevra), Schmidt, R. (Reinhold), Schmidt, H. (Helena), Chen, Y. E. (Y. Eugene), Bandinelli, S. (Stefania), Dedoussis, G. (George), Thanaraj, T. A. (Thangavel Alphonse), Kardia, S. L. (Sharon L. R.), Kato, N. (Norihiro), Schulze, M. B. (Matthias B.), Girotto, G. (Giorgia), Jung, B. (Bettina), Boger, C. A. (Carsten A.), Joshi, P. K. (Peter K.), Bennett, D. A. (David A.), De Jager, P. L. (Philip L.), Lu, X. (Xiangfeng), Mamakou, V. (Vasiliki), Brown, M. (Morris), Caulfield, M. J. (Mark J.), Munroe, P. B. (Patricia B.), Guo, X. (Xiuqing), Ciullo, M. (Marina), Jonas, J. B. (Jost B.), Samani, N. J. (Nilesh J.), Kaprio, J. (Jaakko), Pajukanta, P. (Paivi), Adair, L. S. (Linda S.), Bechayda, S. A. (Sonny Augustin), de Silva, H. J. (H. Janaka), Wickremasinghe, A. R. (Ananda R.), Krauss, R. M. (Ronald M.), Wu, J.-Y. (Jer-Yuarn), Zheng, W. (Wei), den Hollander, A. I. (Anneke, I), Bharadwaj, D. (Dwaipayan), Correa, A. (Adolfo), Wilson, J. G. (James G.), Lind, L. (Lars), Heng, C.-K. (Chew-Kiat), Nelson, A. E. (Amanda E.), Golightly, Y. M. (Yvonne M.), Wilson, J. F. (James F.), Penninx, B. (Brenda), Kim, H.-L. (Hyung-Lae), Attia, J. (John), Scott, R. J. (Rodney J.), Rao, D. C. (D. C.), Arnett, D. K. (Donna K.), Walker, M. (Mark), Koistinen, H. A. (Heikki A.), Chandak, G. R. (Giriraj R.), Yajnik, C. S. (Chittaranjan S.), Mercader, J. M. (Josep M.), Tusie-Luna, T. (Teresa), Aguilar-Salinas, C. A. (Carlos A.), Villalpando, C. G. (Clicerio Gonzalez), Orozco, L. (Lorena), Fornage, M. (Myriam), Tai, E. S. (E. Shyong), van Dam, R. M. (Rob M.), Lehtimaki, T. (Terho), Chaturvedi, N. (Nish), Yokota, M. (Mitsuhiro), Liu, J. (Jianjun), Reilly, D. F. (Dermot F.), McKnight, A. J. (Amy Jayne), Kee, F. (Frank), Jockel, K.-H. (Karl-Heinz), McCarthy, M. I. (Mark, I), Palmer, C. N. (Colin N. A.), Vitart, V. (Veronique), Hayward, C. (Caroline), Simonsick, E. (Eleanor), van Duijn, C. M. (Cornelia M.), Lu, F. (Fan), Qu, J. (Jia), Hishigaki, H. (Haretsugu), Lin, X. (Xu), Marz, W. (Winfried), Parra, E. J. (Esteban J.), Cruz, M. (Miguel), Gudnason, V. (Vilmundur), Tardif, J.-C. (Jean-Claude), Lettre, G. (Guillaume), Elders, P. J. (Petra J. M.), Damrauer, S. M. (Scott M.), Kumari, M. (Meena), Kivimaki, M. (Mika), van der Harst, P. (Pim), Spector, T. D. (Tim D.), Loos, R. J. (Ruth J. F.), Province, M. A. (Michael A.), Psaty, B. M. (Bruce M.), Brandslund, I. (Ivan), Pramstaller, P. P. (Peter P.), Christensen, K. (Kaare), Ripatti, S. (Samuli), Widen, E. (Elisabeth), Hakonarson, H. (Hakon), Grant, S. F. (Struan F. A.), Kiemeney, L. A. (Lambertus A. L. M.), de Graaf, J. (Jacqueline), Loeffler, M. (Markus), Kronenberg, F. (Florian), Gu, D. (Dongfeng), Erdmann, J. (Jeanette), Schunkert, H. (Heribert), Franks, P. W. (Paul W.), Linneberg, A. (Allan), Jukema, J. W. (J. Wouter), Khera, A. V. (Amit, V), Männikkö, M. (Minna), Järvelin, M.-R. (Marjo-Riitta), Kutalik, Z. (Zoltan), Cucca, F. (Francesco), Mook-Kanamori, D. O. (Dennis O.), van Dijk, K. W. (Ko Willems), Watkins, H. (Hugh), Strachan, D. P. (David P.), Grarup, N. (Niels), Sever, P. (Peter), Poulter, N. (Neil), Rotter, J. I. (Jerome, I), Dantoft, T. M. (Thomas M.), Karpe, F. (Fredrik), Neville, M. J. (Matt J.), Timpson, N. J. (Nicholas J.), Cheng, C.-Y. (Ching-Yu), Wong, T.-Y. (Tien-Yin), Khor, C. C. (Chiea Chuen), Sabanayagam, C. (Charumathi), Peters, A. (Annette), Gieger, C. (Christian), Hattersley, A. T. (Andrew T.), Pedersen, N. L. (Nancy L.), Magnusson, P. K. (Patrik K. E.), Boomsma, D. I. (Dorret, I), de Geus, E. J. (Eco J. C.), Cupples, L. A. (L. Adrienne), van Meurs, J. B. (Joyce B. J.), Ghanbari, M. (Mohsen), Rsen, P. G. (Penny Gordon-La), Huang, W. (Wei), Kim, Y. J. (Young Jin), Tabara, Y. (Yasuharu), Wareham, N. J. (Nicholas J.), Langenberg, C. (Claudia), Zeggini, E. (Eleftheria), Kuusisto, J. (Johanna), Laakso, M. (Markku), Ingelsson, E. (Erik), Abecasis, G. (Goncalo), Chambers, J. C. (John C.), Kooner, J. S. (Jaspal S.), de Vries, P. S. (Paul S.), Morrison, A. C. (Alanna C.), North, K. E. (Kari E.), Daviglus, M. (Martha), Kraft, P. (Peter), Martin, N. G. (Nicholas G.), Whitfield, J. B. (John B.), Abbas, S. (Shahid), Saleheen, D. (Danish), Walters, R. G. (Robin G.), Holmes, M. V. (Michael, V), Black, C. (Corri), Smith, B. H. (Blair H.), Justice, A. E. (Anne E.), Baras, A. (Aris), Buring, J. E. (Julie E.), Ridker, P. M. (Paul M.), Chasman, D. I. (Daniel, I), Kooperberg, C. (Charles), Wei, W.-Q. (Wei-Qi), Jarvik, G. P. (Gail P.), Namjou, B. (Bahram), Hayes, M. G. (M. Geoffrey), Ritchie, M. D. (Marylyn D.), Jousilahti, P. (Pekka), Salomaa, V. (Veikko), Hveem, K. (Kristian), Asvold, B. O. (Bjorn Olav), Kubo, M. (Michiaki), Kamatani, Y. (Yoichiro), Okada, Y. (Yukinori), Murakami, Y. (Yoshinori), Thorsteinsdottir, U. (Unnur), Stefansson, K. (Kari), Ho, Y.-L. (Yuk-Lam), Lynch, J. A. (Julie A.), Rader, D. J. (Daniel J.), Tsao, P. S. (Philip S.), Chang, K.-M. (Kyong-Mi), Cho, K. (Kelly), O'Donnell, C. J. (Christopher J.), Gaziano, J. M. (John M.), Wilson, P. (Peter), Rotimi, C. N. (Charles N.), Hazelhurst, S. (Scott), Ramsay, M. (Michele), Trembath, R. C. (Richard C.), van Heel, D. A. (David A.), Tamiya, G. (Gen), Yamamoto, M. (Masayuki), Kim, B.-J. (Bong-Jo), Mohlke, K. L. (Karen L.), Frayling, T. M. (Timothy M.), Hirschhorn, J. N. (Joel N.), Kathiresan, S. (Sekar), Boehnke, M. (Michael), Natarajan, P. (Pradeep), Peloso, G. M. (Gina M.), Brown, C. D. (Christopher D.), Morris, A. P. (Andrew P.), Assimes, T. L. (Themistocles L.), Deloukas, P. (Panos), Sun, Y. V. (Yan, V), and Willer, C. J. (Cristen J.)
Abstract: Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels2, heart disease remains the leading cause of death worldwide3. Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS4‐23 have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele frequencies, effect sizes and linkage-disequilibrium patterns24. Here we conduct a multi-ancestry, genome-wide genetic discovery meta-analysis of lipid levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. We quantify the gain in studying non-European ancestries and provide evidence to support the expansion of recruitment of additional ancestries, even with relatively small sample sizes. We find that increasing diversity rather than studying additional individuals of European ancestry results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction (evaluated in approximately 295,000 individuals from 7 ancestry groupings). Modest gains in the number of discovered loci and ancestry-specific variants were also achieved. As GWAS expand emphasis beyond the identification of genes and fundamental biology towards the use of genetic variants for preventive and precision medicine25, we anticipate that increased diversity of participants will lead to more accurate and equitable26 application of polygenic scores in clinical practice.
Published: 2021

45. Improving interagency service integration of the Australian Nurse Family Partnership Program for First Nations women and babies: a qualitative study.

Author

Massi, L, Hickey, S, Maidment, S-J, Roe, Y, Kildea, S, Nelson, C, Kruske, S, Massi, L, Hickey, S, Maidment, S-J, Roe, Y, Kildea, S, Nelson, C, and Kruske, S

Abstract

Background

The Australian Nurse Family Partnership Program (ANFPP) is an evidence-based, home visiting program that offers health education, guidance, social and emotional support to first-time mothers having Aboriginal and/or Torres Strait Islander (First Nations) babies. The community-controlled sector identified the need for specialised support for first time mothers due to the inequalities in birthing and early childhood outcomes between First Nations' and other babies in Australia. The program is based on the United States' Nurse Family Partnership program which has improved long-term health outcomes and life trajectories for mothers and children. International implementation of the Nurse Family Partnership program has identified interagency service integration as key to program recruitment, retention, and efficacy. How the ANFPP integrates with other services in an Australian urban setting and how to improve this is not yet known. Our research explores the barriers and enablers to interagency service integration for the Australian Nurse Family Partnership Program ANFPP in an urban setting.

Methods

A qualitative study using individual and group interviews. Purposive and snowball sampling was used to recruit clients, staff (internal and external to the program), Elders and family members. Interviews were conducted using a culturally appropriate 'yarning' method with clients, families and Elders and semi-structured interview guide for staff. Interviews were audio-recorded and transcribed prior to reflexive thematic analysis.

Results

Seventy-six participants were interviewed: 26 clients, 47 staff and 3 Elders/family members. Three themes were identified as barriers and three as enablers. Barriers: 1) confusion around program scope, 2) duplication of care, and 3) tensions over 'ownership' of clients. Enablers (existing and potential): 1) knowledge and promotion of the program; 2) cultural safety; and 3) case coordination, co-location and partn

Published

2021

46. Oscillations In The Line-of-Sight Magnetic Field Strength In A Pore Observed By The GREGOR Infrared Spectrograph (GRIS)

Author: Nelson, C. J., Campbell, R. J., Mathioudakis, M., Nelson, C. J., Campbell, R. J., and Mathioudakis, M.
Abstract: Numerous magnetohydrodynamic oscillations have been reported within solar pores over the past decades, including in line-of-sight (LOS) velocities, intensities, and magnetic field strengths. Our aim is to identify whether high-amplitude oscillations in the LOS magnetic field strength can be detected within a pore located in Active Region 12748 and to investigate which physical mechanisms could be responsible for them. A solar pore was observed on the 1st September 2019 using the GREGOR Infrared Spectrograph for around one hour. Full-Stokes vectors were sampled in a 37 A window containing the Fe I 15648.52 A line (effective Lande g-factor of 3). The LOS magnetic field strength is inferred using the strong-field approximation. The Stokes Inversion based on Response functions code is used to gain a more complete understanding the properties of the solar atmosphere at the locations of these oscillations. Oscillations of more than 100 G are observed in the LOS magnetic field in the period window 600-1272 s at three localised (>1"^2) regions. These oscillations have coherence across individual regions indicating that jitter cannot account for their occurrence. Longer-period amplitude variations, amplitudes over 200 G, are also detected but these have periods outside of the cone-of-influence. Numerical inversions confirm both oscillations in the LOS magnetic field strength at optical depths of around log-tau_5000=-0.5 (potentially caused by compression) and other effects (e.g., changes in the optical depth or the inclination of the field) may account for these changes. The oscillations in the separations of the Stokes-V lobes of the 15648.52 A line appear to be solar in nature. Future work will be required to understand whether these are truly oscillations in the magnetic field strength at a specific depth in the solar atmosphere or whether other effects are responsible for these signatures., Comment: 11 pages, 8 figures, 2 tables, Accepted for A&A
Published: 2021
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47. Improving interagency service integration of the Australian Nurse Family Partnership Program for First Nations women and babies: a qualitative study.

Author

Massi, L, Hickey, S, Maidment, S-J, Roe, Y, Kildea, S, Nelson, C, Kruske, S, Massi, L, Hickey, S, Maidment, S-J, Roe, Y, Kildea, S, Nelson, C, and Kruske, S

Abstract

Background

Methods

Results

Published

2021

48. Effect of a Birthing on Country service redesign on maternal and neonatal health outcomes for First Nations Australians: a prospective, non-randomised, interventional trial.

Author: Kildea, S, Gao, Y, Hickey, S, Nelson, C, Kruske, S, Carson, A, Currie, J, Reynolds, M, Wilson, K, Watego, K, Costello, J, Roe, Y, Kildea, S, Gao, Y, Hickey, S, Nelson, C, Kruske, S, Carson, A, Currie, J, Reynolds, M, Wilson, K, Watego, K, Costello, J, and Roe, Y
Abstract: Background: There is an urgency to redress unacceptable maternal and infant health outcomes for First Nations families in Australia. A multi-agency partnership between two Aboriginal Community-controlled health services and a tertiary hospital in urban Australia designed, implemented, and evaluated the new Birthing in Our Community (BiOC) service. In this study, we aimed to assess and report the clinical effectiveness of the BiOC service on key maternal and infant health outcomes compared with that of standard care. Methods: Pregnant women attending the Mater Mothers Public Hospital (Brisbane, QLD, Australia) who were having a First Nations baby were invited to receive the BiOC service. In this prospective, non-randomised, interventional trial of the service, we specifically enrolled women who intended to birth at the study hospital, and had a referral from a family doctor or Aboriginal Medical Service. Participants were offered either standard care services or the BiOC service. Prespecified primary outcomes to test the effectiveness of the BiOC service versus standard care were the proportion of women attending five or more antenatal visits, smoking after 20 weeks of gestation, who had a preterm birth (<37 weeks), and who were exclusively breastfeeding at discharge from hospital. We used inverse probability of treatment weighting to balance confounders and calculate treatment effect. This trial is registered with the Australian New Zealand Clinical Trial Registry, ACTRN12618001365257. Findings: Between Jan 1, 2013, and June 30, 2019, 1867 First Nations babies were born at the Mater Mothers Public Hospital. After exclusions, 1422 women received either standard care (656 participants) or the BiOC service (766 participants) and were included in the analyses. Women receiving the BiOC service were more likely to attend five or more antenatal visits (adjusted odds ratio 1·54, 95% CI 1·13–2·09; p=0·0064), less likely to have an infant born preterm (0·62, 0·42–0·93; p=0·01
Published: 2021

49. Effect of a Birthing on Country service redesign on maternal and neonatal health outcomes for First Nations Australians: a prospective, non-randomised, interventional trial.

Author: Kildea, S, Gao, Y, Hickey, S, Nelson, C, Kruske, S, Carson, A, Currie, J, Reynolds, M, Wilson, K, Watego, K, Costello, J, Roe, Y, Kildea, S, Gao, Y, Hickey, S, Nelson, C, Kruske, S, Carson, A, Currie, J, Reynolds, M, Wilson, K, Watego, K, Costello, J, and Roe, Y
Abstract: Background: There is an urgency to redress unacceptable maternal and infant health outcomes for First Nations families in Australia. A multi-agency partnership between two Aboriginal Community-controlled health services and a tertiary hospital in urban Australia designed, implemented, and evaluated the new Birthing in Our Community (BiOC) service. In this study, we aimed to assess and report the clinical effectiveness of the BiOC service on key maternal and infant health outcomes compared with that of standard care. Methods: Pregnant women attending the Mater Mothers Public Hospital (Brisbane, QLD, Australia) who were having a First Nations baby were invited to receive the BiOC service. In this prospective, non-randomised, interventional trial of the service, we specifically enrolled women who intended to birth at the study hospital, and had a referral from a family doctor or Aboriginal Medical Service. Participants were offered either standard care services or the BiOC service. Prespecified primary outcomes to test the effectiveness of the BiOC service versus standard care were the proportion of women attending five or more antenatal visits, smoking after 20 weeks of gestation, who had a preterm birth (<37 weeks), and who were exclusively breastfeeding at discharge from hospital. We used inverse probability of treatment weighting to balance confounders and calculate treatment effect. This trial is registered with the Australian New Zealand Clinical Trial Registry, ACTRN12618001365257. Findings: Between Jan 1, 2013, and June 30, 2019, 1867 First Nations babies were born at the Mater Mothers Public Hospital. After exclusions, 1422 women received either standard care (656 participants) or the BiOC service (766 participants) and were included in the analyses. Women receiving the BiOC service were more likely to attend five or more antenatal visits (adjusted odds ratio 1·54, 95% CI 1·13–2·09; p=0·0064), less likely to have an infant born preterm (0·62, 0·42–0·93; p=0·01
Published: 2021

50. Can you be a follower even when you do not follow the leader? : Yes, you can

Author: Almeida, Teresa, Ramalho, Nelson C., Esteves, Francisco, Almeida, Teresa, Ramalho, Nelson C., and Esteves, Francisco
Abstract: In the ongoing debate in the area of critical leadership studies, the nature of leader–follower relationships is a thorny issue. The nature of followership has been questioned, especially whether followers can display resistance behaviours while maintaining their follower position. Addressing this issue requires a dialectical approach in which followers and leaders alike are primary elements in leadership co-production. Followers who face destructive leaders are of special interest when leadership is studied as a co-creational process. This context favours the emergence of a full range of behavioural profiles in which passives and colluders will illustrate the destructive leadership co-production process, and those who resist demonstrate that followers may not follow the leader and still keep a followership purpose. A two-step data analysis procedure was conducted based on the behaviour descriptions of 123 followers having a destructive leader. A qualitative analysis (i.e. content analysis) showed a set of behaviours and their antecedents that suggest three main groups of followers: resisters, obedient and mixed behaviour. Treating these data quantitatively (i.e. latent class analysis), six followers’ profiles emerged: active resistance, passive resistance, passive obedience, conflict avoidance, support and mixed. Our findings provide evidence that followers who resist may do it for the sake of the organisation. We discuss our findings in light of followership theory, whereby joining role-based and constructionist approaches allows us to argue that followers may still be followers even when they do not invariably follow their leader.
Published: 2021
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