Search

Your search keyword '"New York State Psychiatric Institute"' showing total 3 results
Start Over Author "New York State Psychiatric Institute" Database OAIster
3 results on '"New York State Psychiatric Institute"'

1. Interactive effects of subanesthetic ketamine and subhypnotic lorazepam in humans

Author

Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109-0504, USA, US, Department of Psychiatry, Yale University School of Medicine, Connecticut, USA, US, Psychiatry Service (116-A), VA Medical Center, West Haven, CT 06516, USA, US, New York State Psychiatric Institute, 722 W. 168th Street, New York, NY 10032, USA, US, Ann Arbor, Abi-Saab, Danielle, Krystal, John H., Bremner, J. Douglas, Charney, Dennis S., Karper, Laurence P., Bennett, Alexandre, Stetson, Philip L., Morrissey, Kristen, Suckow, Raymond F., D???souza, D. Cyril, Bowers Jr., M.B., Abi-Dargham, Anissa, Heninger, George R., Upjohn Center for Clinical Pharmacology, University of Michigan Medical Center, Ann Arbor, MI 48109-0504, USA, US, Department of Psychiatry, Yale University School of Medicine, Connecticut, USA, US, Psychiatry Service (116-A), VA Medical Center, West Haven, CT 06516, USA, US, New York State Psychiatric Institute, 722 W. 168th Street, New York, NY 10032, USA, US, Ann Arbor, Abi-Saab, Danielle, Krystal, John H., Bremner, J. Douglas, Charney, Dennis S., Karper, Laurence P., Bennett, Alexandre, Stetson, Philip L., Morrissey, Kristen, Suckow, Raymond F., D???souza, D. Cyril, Bowers Jr., M.B., Abi-Dargham, Anissa, and Heninger, George R.

Abstract

???Ketamine is an N -methyl- D -aspartate (NMDA) receptor antagonist with psychotogenic and dissociative effects in healthy humans. These cognitive and perceptual effects in humans are reportedly reduced by benzodiazepine premedication. This study assessed the interactive effects of a ketamine (IV bolus of 0.26???mg/kg followed by an infusion of 0.65???mg/kg per hour) and lorazepam 2???mg., PO, in humans. Twenty-three healthy subjects completed 4 test days involving the oral administration of lorazepam or matched placebo 2???h prior to the IV infusion of ketamine or placebo. Ketamine: 1) produced behaviors similar to the positive and negative symptoms of schizophrenia as assessed by the Brief Psychiatric Rating Scale (BPRS); 2) evoked perceptual alterations as measured by the Clinician-Administered Dissociative States Scale (CADSS); 3) impaired performance on the Wisconsin Card Sorting Test (WCST) and other tests sensitive to frontal cortical impairment; and 4) had amnestic effects. Lorazepam produced attention impairments, concrete proverb interpretations, and recall impairments. Lorazepam reduced ketamine-associated emotional distress and there was a non-significant trend for it to decrease perceptual alterations produced by ketamine. However, it failed to reduce many cognitive and behavioral effects of ketamine, including psychosis. Further, lorazepam exacerbated the sedative, attention-impairing, and amnestic effects of ketamine. There was no evidence of pharmacokinetic interaction between these medications. These data suggest that subhypnotic lorazepam and ketamine show a spectrum of interactive effects, ranging from antagonism to potentiation.

Published
2006

2. Clinical calibration of DSM-IV diagnoses in the World Mental Health (WMH) version of the World Health Organization (WHO) Composite International Diagnostic Interview (WMH-CIDI)

Author

Institute for Social Research, University of Michigan, Ann Arbor MI, USA, Department of Health Care Policy, Harvard Medical School, Boston MA, USA ; Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston MA, USA 02115., Department of Health Care Policy, Harvard Medical School, Boston MA, USA, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick NJ, USA, New York State Psychiatric Institute, New York City NY, USA, Kessler, Ronald C., Abelson, Jamie M., Demler, Olga, Escobar, Javier I., Gibbon, Miriam, Guyer, Margaret E., Howes, Mary J., Jin, Robert, Vega, William A., Walters, Ellen E., Wang, Philip, Zaslavsky, Alan, Zheng, Hui, Institute for Social Research, University of Michigan, Ann Arbor MI, USA, Department of Health Care Policy, Harvard Medical School, Boston MA, USA ; Department of Health Care Policy, Harvard Medical School, 180 Longwood Avenue, Boston MA, USA 02115., Department of Health Care Policy, Harvard Medical School, Boston MA, USA, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick NJ, USA, New York State Psychiatric Institute, New York City NY, USA, Kessler, Ronald C., Abelson, Jamie M., Demler, Olga, Escobar, Javier I., Gibbon, Miriam, Guyer, Margaret E., Howes, Mary J., Jin, Robert, Vega, William A., Walters, Ellen E., Wang, Philip, Zaslavsky, Alan, and Zheng, Hui

Published
2006

3. Psychiatric Institute archived websites

Author

This finding aid was compiled by staff of the New York State Archives., New York State Psychiatric Institute, This finding aid was compiled by staff of the New York State Archives., and New York State Psychiatric Institute

Abstract

This series consists of archival copies of the publicly accessible websites of the New York State Psychiatric Institute, which is part of the New York State Office of Mental Health.

Catalog

Books, media, physical & digital resources
See catalog results