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Domain generation algorithms (DGAs) can be categorized into three types: zero-knowledge, partial-knowledge, and full-knowledge. While prior research merely focused on zero-knowledge and full-knowledge types, we characterize their anti-detection ability and practicality and find that zero-knowledge DGAs present low anti-detection ability against detectors, and full-knowledge DGAs suffer from low practicality due to the strong assumption that they are fully detector-aware. Given these observations, we propose PKDGA, a partial knowledge-based domain generation algorithm with high anti-detection ability and high practicality. PKDGA employs the reinforcement learning architecture, which makes it evolve automatically based only on the easily-observable feedback from detectors. We evaluate PKDGA using a comprehensive set of real-world datasets, and the results demonstrate that it reduces the detection performance of existing detectors from 91.7% to 52.5%. We further apply PKDGA to the Mirai malware, and the evaluations show that the proposed method is quite lightweight and time-efficient., Comment: 12 pages,11 figures